KEGG   Bison bison bison (American bison): 104980280
Entry
104980280         CDS       T08726                                 
Symbol
ROCK1
Name
(RefSeq) rho-associated protein kinase 1 isoform X1
  KO
K04514  Rho-associated protein kinase 1 [EC:2.7.11.39]
Organism
bbis  Bison bison bison (American bison)
Pathway
bbis04022  cGMP-PKG signaling pathway
bbis04024  cAMP signaling pathway
bbis04062  Chemokine signaling pathway
bbis04071  Sphingolipid signaling pathway
bbis04270  Vascular smooth muscle contraction
bbis04350  TGF-beta signaling pathway
bbis04360  Axon guidance
bbis04510  Focal adhesion
bbis04520  Adherens junction
bbis04530  Tight junction
bbis04611  Platelet activation
bbis04670  Leukocyte transendothelial migration
bbis04810  Regulation of actin cytoskeleton
bbis04921  Oxytocin signaling pathway
bbis05135  Yersinia infection
bbis05163  Human cytomegalovirus infection
bbis05200  Pathways in cancer
bbis05205  Proteoglycans in cancer
bbis05206  MicroRNAs in cancer
Brite
KEGG Orthology (KO) [BR:bbis00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04350 TGF-beta signaling pathway
    104980280 (ROCK1)
   04071 Sphingolipid signaling pathway
    104980280 (ROCK1)
   04024 cAMP signaling pathway
    104980280 (ROCK1)
   04022 cGMP-PKG signaling pathway
    104980280 (ROCK1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    104980280 (ROCK1)
   04520 Adherens junction
    104980280 (ROCK1)
   04530 Tight junction
    104980280 (ROCK1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    104980280 (ROCK1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    104980280 (ROCK1)
   04670 Leukocyte transendothelial migration
    104980280 (ROCK1)
   04062 Chemokine signaling pathway
    104980280 (ROCK1)
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    104980280 (ROCK1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    104980280 (ROCK1)
  09158 Development and regeneration
   04360 Axon guidance
    104980280 (ROCK1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    104980280 (ROCK1)
   05206 MicroRNAs in cancer
    104980280 (ROCK1)
   05205 Proteoglycans in cancer
    104980280 (ROCK1)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    104980280 (ROCK1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    104980280 (ROCK1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:bbis01001]
    104980280 (ROCK1)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:bbis03036]
    104980280 (ROCK1)
Enzymes [BR:bbis01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.39  ROCK-subfamily protein kinase
     104980280 (ROCK1)
Protein kinases [BR:bbis01001]
 Serine/threonine kinases: AGC group
  DMPK family [OT]
   104980280 (ROCK1)
Chromosome and associated proteins [BR:bbis03036]
 Eukaryotic type
  Centrosome formation proteins
   Kinases and associated factors
    104980280 (ROCK1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Rho_Binding PH C1_1 Cortex-I_coil Pkinase_C APH
Other DBs
NCBI-GeneID: 104980280
NCBI-ProteinID: XP_010827209
Ensembl: ENSBBBG00000021280
UniProt: A0A6P3GKA5
LinkDB
Position
Unknown
AA seq 1354 aa
MSTGDSFETRFEKIDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYK
DTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAF
FWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTA
EVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDY
ISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFP
DDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLS
SDIDTSNFDDLEEDKGDEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNRTSSNV
DKSLQENLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLEST
VSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKL
AQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSITQLESLNRELQERNRILENSKSQMD
KDYYQLQAVLEAERRDRGHDSEKIGDLQARITSLQEEVKHLKHNLERVEGERKEAQDMLN
HSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKL
KEERDAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLIENKDRMEDEVKNLTLQLEQES
NKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMR
ELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQSEKETLATQLDLAETKAE
SEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTLSRLEETNSMLTKDIELLRKENE
ELTDKMRKAEEEYKLKKEEEINILKAAFEKNINTERTLKTQAVNKLAEIMNRKDFKIDRK
KANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNEMQAQLVEECTHKNELQMQL
ASKESDIEQLRAKLLDLSDSTSVASFPSADETDGNLPESRIEGWLSIPNRGNIKRYGWKK
QYVVVSSKKILFYNDEQDKEQSNPSMVLDIDKLFHVRPVTQGDVYRAETEEIPKIFQILY
ANEGECRKDLEVEPVQQAEKTNFQNHKGHEFIPTLYHFPANCEACAKPLWHVFKPPPALE
CRRCHVKCHRDHIDKKEDLISPCKVSYDVTSARDMLLLACSQDEQKKWVTHLVKKIPKNP
PSGFVRASPRTLSTRSTANQSFRKVVKNTSGKAS
NT seq 4065 nt   +upstreamnt  +downstreamnt
atgtcgactggcgacagttttgagactcggtttgaaaaaatcgacaacctgctgcgggat
cccaaatcggaagtgaattcagattgtctgctggatggattggatgctttggtatatgat
ttggattttcctgccttaagaaaaaacaaaaatattgacaactttttaagcagatataaa
gacacaataaataaaattagagatttacgaatgaaagctgaagattatgaagtagtgaag
gtgattggtagaggtgcatttggagaagttcaattggtaaggcataaatccaccaggaag
gtgtacgctatgaagctcctcagcaaatttgaaatgattaagagatctgattctgctttt
ttctgggaagaaagggacatcatggcttttgctaacagtccttgggttgttcagctgttt
tatgcattccaagatgatcgttatctctacatggtaatggaatacatgcctggtggagat
cttgtaaatttaatgagcaactatgacgtgcctgaaaaatgggcccgattctatactgca
gaagtagttcttgcattggatgcaatccattccatgggttttatccatagagatgtgaag
cctgataacatgctgctggataaatctggacatttgaagttagcagattttggtacttgt
atgaagatgaataaggaaggcatggtacgatgtgatacagcagttggaacacctgattat
atttctcctgaagtattaaaatctcaaggtggcgatggttattatggacgagaatgtgac
tggtggtcagttggggtatttttatatgaaatgcttgtaggtgatacaccattttatgca
gattctctggttggaacttacagtaagattatgaaccataaaaattctcttaccttccct
gatgataatgacatatcaaaagaagcaaaaaatcttatttgtgccttccttactgacaga
gaggtgagattagggcgaaatggtgtagaagaaatcaaacgacatctcttcttcaaaaat
gatcagtgggcttgggaaacacttcgagacactgtagcaccagttgtacctgatttaagt
agtgacatagacacaagtaactttgatgacttggaagaagataaaggagatgaagaaaca
ttccctatacctaaagcttttgttggcaatcaactaccttttgtaggatttacatattat
agcaatcgtagatacttatcttcagcaaatcctaacgataacagaactagctctaatgtg
gataaaagcttgcaggaaaatttgcagaaaacaatttataagctggaagaacagttacat
aatgaaatgcaattaaaagatgaaatggagcagaagtgcagaacgtcaaacataaaacta
gacaagataatgaaagaattggacgaagaggggaatcaaagaagaaatctagaatctaca
gtatctcagattgagaaggagaaaatgttgctacagcacagaattaatgaataccaaaga
aaagcagaacaggaaaatgagaagaggaggaatgtagaaaatgaagtttctacattaaag
gatcagttggaagacttaaagaaagtcagccagaattcacagcttgctaatgagaagctg
gcacaattacaaaagcagctagaagaagccaatgacttacttaggacagaatcagacaca
gcggttagattaaggaagagtcacacagagatgagcaaatccatcactcagctagagtcc
ctaaacagagaactgcaggagagaaatagaattttagagaattccaagtcacaaatggac
aaagattattaccaactacaggctgtattagaagctgaacgaagagacagaggtcatgat
tctgagaagattggagacctacaagctcgaattacatctttacaagaggaggtgaagcat
ctcaaacataatcttgaaagagtggaaggagaaagaaaagaggctcaagacatgcttaat
cattcagaaaaggaaaagaataacttagaaatagatttaaactacaagcttaaatcatta
cagcaacgattagaacaagaggtaaatgaacataaagtaaccaaagctcgtttaactgac
aaacatcaatctattgaagaggcaaagtctgttgcaatgtgtgagatggaaaaaaagctg
aaggaggagagagacgctcgagagaaggctgaaaatagggttgttcagattgagaagcag
tgctctatgctagatgttgatctgaagcaatctcagcagaagctggagcatttgattgaa
aataaagacaggatggaggatgaagttaagaatctaacgctacagctggagcaggaatca
aacaagcgacttttgttacaaaatgaattgaagactcaagcatttgaggcagacaattta
aaaggtttagaaaagcagatgaaacaggaaataaatactttattggaagcaaagagatta
ttggaatttgaattagctcagcttacaaaacagtacagagggaatgaagggcagatgcgg
gagctgcaggatcagctggaagcggagcagtatttctcgacactttataaaacccaggta
aaggaacttaaggaagaaattgaagaaaaaaacagagaaaacttaaagaaaatacaggaa
ctacaaagtgaaaaagaaactcttgctactcagttggatctagcggaaacaaaggctgaa
tctgagcagttggctcgagggcttctggaagaacagtattttgaactgacccaagaaagc
aagaaagctgcctcaagaaatagacaagagattacagataaagatcacactcttagtcgg
cttgaagaaacgaatagcatgctaaccaaagatattgaattattaagaaaagaaaacgaa
gagctaactgataaaatgaggaaggcagaggaagaatataaattgaagaaggaggaggag
atcaatatccttaaagctgcctttgaaaagaatatcaatacagaacgaacccttaaaaca
caggctgttaacaagttggcagaaataatgaatcgaaaggactttaaaatcgatagaaag
aaagcaaatacgcaggatttgagaaagaaagaaaaagaaaatcgaaagctccaacttgaa
ctcaaccaggaaagagagaaattcaaccaaatggtagtgaaacatcagaaggagctgaat
gaaatgcaagcgcaattggtagaagaatgtacacataagaatgagcttcagatgcagctg
gccagcaaagagagtgacattgagcagctgcgtgccaaactgttggacctttcagattct
acaagtgttgctagttttcccagtgctgatgaaactgatggaaaccttccagaatcaaga
attgaaggttggctttcaataccaaatagaggaaatatcaaaagatatggctggaagaaa
cagtatgttgtggtaagcagcaaaaaaattttgttctataatgatgaacaagataaggaa
caatccaatccgtctatggtattggacattgataaattgtttcatgttcgtcctgtaaca
caaggagatgtatacagagctgaaactgaagaaattcctaaaatattccagatactgtat
gcaaatgaaggtgaatgtagaaaagacttagaggtggaaccagtacaacaagctgaaaaa
acaaattttcaaaatcacaaaggccatgagttcattcctacactctaccactttcccgcc
aactgtgaggcctgtgccaaacctctctggcatgtttttaagccaccccctgccctggag
tgtcgaagatgccatgttaagtgccacagagaccacatagataagaaagaggacttgatt
tctccatgtaaagtaagttatgatgtaacatcagcaagagatatgctgctgctagcgtgt
tctcaggatgaacaaaaaaaatgggtaactcatttagtaaagaagatccctaagaatcca
ccatctggttttgtgcgtgcatcccctcgaacactttctacaaggtccactgcaaatcag
tctttccggaaagtggtcaaaaatacatctggaaaagctagttaa

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