KEGG   Bison bison bison (American bison): 104981877
Entry
104981877         CDS       T08726                                 
Symbol
CACNA1S
Name
(RefSeq) LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1S
  KO
K04857  voltage-dependent calcium channel L type alpha-1S
Organism
bbis  Bison bison bison (American bison)
Pathway
bbis04010  MAPK signaling pathway
bbis04020  Calcium signaling pathway
bbis04022  cGMP-PKG signaling pathway
bbis04024  cAMP signaling pathway
bbis04260  Cardiac muscle contraction
bbis04261  Adrenergic signaling in cardiomyocytes
bbis04270  Vascular smooth muscle contraction
bbis04723  Retrograde endocannabinoid signaling
bbis04725  Cholinergic synapse
bbis04726  Serotonergic synapse
bbis04727  GABAergic synapse
bbis04911  Insulin secretion
bbis04912  GnRH signaling pathway
bbis04921  Oxytocin signaling pathway
bbis04924  Renin secretion
bbis04925  Aldosterone synthesis and secretion
bbis04927  Cortisol synthesis and secretion
bbis04929  GnRH secretion
bbis04934  Cushing syndrome
bbis04935  Growth hormone synthesis, secretion and action
bbis05010  Alzheimer disease
bbis05020  Prion disease
bbis05022  Pathways of neurodegeneration - multiple diseases
bbis05207  Chemical carcinogenesis - receptor activation
bbis05410  Hypertrophic cardiomyopathy
bbis05412  Arrhythmogenic right ventricular cardiomyopathy
bbis05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:bbis00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    104981877 (CACNA1S)
   04020 Calcium signaling pathway
    104981877 (CACNA1S)
   04024 cAMP signaling pathway
    104981877 (CACNA1S)
   04022 cGMP-PKG signaling pathway
    104981877 (CACNA1S)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    104981877 (CACNA1S)
   04929 GnRH secretion
    104981877 (CACNA1S)
   04912 GnRH signaling pathway
    104981877 (CACNA1S)
   04921 Oxytocin signaling pathway
    104981877 (CACNA1S)
   04935 Growth hormone synthesis, secretion and action
    104981877 (CACNA1S)
   04924 Renin secretion
    104981877 (CACNA1S)
   04925 Aldosterone synthesis and secretion
    104981877 (CACNA1S)
   04927 Cortisol synthesis and secretion
    104981877 (CACNA1S)
  09153 Circulatory system
   04260 Cardiac muscle contraction
    104981877 (CACNA1S)
   04261 Adrenergic signaling in cardiomyocytes
    104981877 (CACNA1S)
   04270 Vascular smooth muscle contraction
    104981877 (CACNA1S)
  09156 Nervous system
   04727 GABAergic synapse
    104981877 (CACNA1S)
   04725 Cholinergic synapse
    104981877 (CACNA1S)
   04726 Serotonergic synapse
    104981877 (CACNA1S)
   04723 Retrograde endocannabinoid signaling
    104981877 (CACNA1S)
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    104981877 (CACNA1S)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    104981877 (CACNA1S)
   05020 Prion disease
    104981877 (CACNA1S)
   05022 Pathways of neurodegeneration - multiple diseases
    104981877 (CACNA1S)
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    104981877 (CACNA1S)
   05412 Arrhythmogenic right ventricular cardiomyopathy
    104981877 (CACNA1S)
   05414 Dilated cardiomyopathy
    104981877 (CACNA1S)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    104981877 (CACNA1S)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:bbis04040]
    104981877 (CACNA1S)
Ion channels [BR:bbis04040]
 Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   104981877 (CACNA1S)
SSDB
Motif
Pfam: Ion_trans GPHH Ca_chan_IQ PKD_channel CAC1F_C
Other DBs
NCBI-GeneID: 104981877
NCBI-ProteinID: XP_010829431
Ensembl: ENSBBBG00000009241
UniProt: A0A6P3GIU9
LinkDB
Position
Unknown
AA seq 1948 aa
MEPAPAQDEGLRRKQAKKPVPEVLPRPPRALFCLTLQNPVRKACISIVEWKPFETIILLT
IFANCVALAVYLPMPEDDSNRLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRS
GWNVLDFIIVFLGVFTVILEQVNLIQSNTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVP
SLQVVLNSIFKAMLPLFHIALLVLFMVVIYAIIGLELFKGKMHKTCYFIGTDIVATVENE
KPSPCARTGSGRPCTISGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYW
VNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLE
EDLRGYLSWITQGEVMDVDDLREGKLALDEGGSDTESLYEIAGLNKVIQFIRHWRQWNRV
FRWKCHDVVKSRVFYWLVILIVALNTLSIASEHHHQPLWLTHLQDVANRVLLALFTVEML
MKMYGLGLRQYFMSIFNRFDCFVVCSGLLEILLVESGAMSPLGISVLRCIRLLRIFKITK
YWTSLSNLVASLLNSIRSIASLLFLLFLFIVVFALLGMQLFGGRYDFEDTEVRRSNFDSF
PQALISVFQVLTGEDWNSVMYNGIMAYGGPSYPGVLVCIYFIILFVCGNYILLNVFLAIA
VDNLAEAESLTSAQKAKAEERRRRKMSKGLPDKSEEEKVTVAKKLEQKPKGEGIPTTAKL
KIDEFESNVNEVKDPYPSADFPGDDEEDEPEVPISPRPRPLAELQLKEKAVPIPEASAFF
IFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPLRAESVRNQVMAAKLWVLG
FSSDDACRLSPXMTTYGAFLHKGSFCRNYFNILDLXXXXXXXXQAGRELSLHSRPLGWAG
REKGQVPTRLPPLQHVVQCVFVAIRTIGNIVLVTTLLQFMFACIGVQLFKGKFFSCNDLS
KMTEEECRGYYYVYKDGDPTQIEVRPRQWVHNAFHFDNVLSAMMSLFTVSTFEGWPELLY
KAIDSHEEDKGPVYNHRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCEL
DKNQRQCVQYALKARPLRCYIPKNPYQYRVWYIVTSSYFEYLMFALIMLNTICLGMQHYN
QSEQMNHISDILNVAFTIIFTLEMVLKLMAFKARGYFGDPWNVFDFLIVIGSIIDVILSE
IDTFLASSGGLYCLGGGCGNVVIPGCMSLPRSPTSSALQLACLGLAAGLHGADALRAPCP
EQAPEGPVGGGRRLCVTRVCMGVVGRGALADGIPVRPAHCLAPRPPRLRLSKPRALGPAR
EGPRTGRAVEPCTLSRHPRPQALPYVALLIVMLFFIYAVIGMQMFGKIALVDGTQINRNN
NFQTFPQAVLLLFRCATGEAWQEILLACSYGQLCDPESDYAPGEEYTCGTDFAYYYFLSF
YMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWAEYDPEATGRIKHLDVVT
LLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFALVRTALKIKTEGNFE
QANEELRAIIKKVWKRTSMKLLDQVIPPIGDDEVTVGKFYATFLIQEHFRKFMRRQEEYY
GYRPKKDTVQIQAGLRTIEEEAAPEIRRTISGDLTAEEELERAMVEAAMEEGIFRRTGGL
FGQVDSFLERTNSLAPHMANQRPLQFTEIEMEEIESPVFLEDFPQSPSTHPLARANTNNA
NANVASGNGNHGNSPAFPSVHYEGELAGETETPATRGGLFGQPRGALGPHGKSRVEWPQG
QLPRRRTPRAQAPAASCQHAGAESQVPEEQSPTPGSLPGEAPPGSRTEDGTPGGPAPAMA
LLIREALVRGGLDSLAADANFIMATGQALAEACRMEPREVEVAAAELLQGRESLEGVPGA
RGCPGLGSSLGSLDLREGSQETLIPRRP
NT seq 5847 nt   +upstreamnt  +downstreamnt
atggagccggccccggcccaggacgagggcctgcggaggaagcaggccaagaagcccgtc
ccggaggtcctgcccaggccgccccgggccttgttctgcttgaccctccagaaccccgtg
cggaaagcctgcatcagcatcgtcgagtggaaacccttcgagaccatcatcttactcacc
atctttgccaactgcgtggccctggccgtgtacctgcccatgccggaggacgacagcaac
agactgaacctcggcctggagaagctggaatacttcttcctcatcgtcttctccatcgag
gccgccatgaagatcatcgcctacggcttcctgttccaccaggatgcctacctgcgcagc
ggctggaacgtgctggatttcatcatcgtcttcctgggggtcttcaccgtgatcctggag
caggtcaacctcatccagagcaacacggccccgatgagcagcaaaggcgcgggcctggac
gtcaaggcactgcgggccttccgcgtgctccgtccgctccggctggtgtccggggtgccc
agcctgcaggtggtcctcaactccatcttcaaggccatgctgccgctcttccacatcgcc
ctgctggtgctcttcatggtcgtcatctacgccatcatcggcctcgagctcttcaagggc
aagatgcacaagacctgctacttcattggcacggacatcgtggccacggtggagaacgag
aagccgtccccctgcgcccggacgggctccggccgcccctgcaccatcagcggcagcgag
tgccgtggcgggtggcccggccccaaccacggcatcacccacttcgacaacttcggcttc
tccatgctcaccgtgtaccagtgcatcaccatggagggctggaccgacgtcctctactgg
gtgaatgacgccatcgggaacgagtggccctggatctactttgtcaccctcatcctgctg
ggctccttcttcatcctcaacctggtgctgggcgtcctgagcggggaattcaccaaggag
cgggagaaggccaagtccagggggaccttccagaagctgcgggagaagcagcagctggag
gaggacctccggggctacctgagctggatcacgcagggcgaggtcatggacgtggatgac
ttgagagaagggaagctggctctggatgaaggcggctccgacacggagagcctgtacgaa
atcgcgggcttgaacaaagttatccagttcatccgacactggaggcagtggaaccgcgtc
ttccgctggaagtgccacgatgtggtgaagtccagggtcttctactggctggtcatcctg
atcgtcgctctcaacacactgtcgatcgcctcagagcaccaccaccagcctctctggttg
acccacctgcaagacgtggccaaccgggtgctgctggccctgttcaccgtggagatgctg
atgaagatgtacgggctgggcctgcgccagtacttcatgtccatcttcaaccgcttcgac
tgcttcgtggtgtgcagcggcctcctggagatcctgctggtggagtcgggtgccatgtcg
cccctgggcatctcggtgctgcgctgcatccgtctgctgcggatcttcaagatcaccaag
tactggacgtcgctgagcaacctggtggcgtcgctgctcaactccatccgctccatcgcc
tcgctgctcttcctgctcttcctcttcatcgtggtcttcgctctgctgggcatgcagctc
ttcgggggcaggtacgacttcgaggacaccgaggtgcggcgtagcaacttcgacagcttc
ccacaggcccttatcagcgtcttccaggtgctgacaggagaggactggaactccgtgatg
tacaacgggatcatggcctacggcggcccatcctaccccggggtgctcgtctgcatttac
ttcatcatcctgtttgtttgcggcaactacatcctgctcaacgtcttcctggccatcgct
gtggacaacctggcagaggccgagagcctgacttctgcccagaaggccaaggctgaagag
cggagacgcaggaagatgtccaagggtctcccggacaagtcagaggaggagaaggtgacg
gtggccaagaagctggagcagaaacccaagggggaaggtatccccaccaccgccaagctg
aagatcgacgagtttgaatccaacgtcaacgaggtgaaggacccctacccctcagctgac
ttcccaggggacgatgaggaagacgagccggaggtcccaataagcccccggccccgtccg
ctggctgagctgcagctgaaggagaaggcggtgcccattccagaagccagtgccttcttc
atcttcagccccaccaacaagatccgcgtcctgtgccaccgcattgtcaatgccacctgg
ttcactaacttcatcctgctcttcatcctgctcagcagtgccgccctggccgccgaggac
cccctccgggctgagtccgtgaggaaccaggtgatggcagccaagctctgggtgctgggt
tttagcagtgatgatgcatgccgcctctccccctagatgaccacctacggggccttcctg
cacaagggctccttctgccgcaactacttcaacatcctggacctgnnnnnnnnnnnnnnn
nnnnnnnaacaagctgggagggagctaagcttgcactcgaggcccctgggctgggctggg
cgtgagaaggggcaggtgccgaccaggctcccacccctgcagcacgtggtacagtgtgtg
ttcgtggccatccgcaccatcgggaacatcgtcctggtcaccaccctcctgcagttcatg
ttcgcctgcatcggcgtccagctcttcaaggggaagttcttcagctgcaatgacttgtcc
aagatgacggaggaggagtgcaggggctactactatgtgtacaaagatggagaccccaca
cagatagaggtgcgtccccgccagtgggtgcacaacgccttccacttcgacaacgtgctt
tcggccatgatgtccctcttcaccgtgtccaccttcgagggatggcctgagctgctgtac
aaggccattgactctcatgaggaggacaagggccccgtgtacaaccaccgcgtggagatg
gccattttcttcatcatctacatcatccttatcgccttcttcatgatgaacatcttcgtg
ggctttgtcatcgtcaccttccaggagcagggggagactgagtacaagaactgtgagctg
gacaagaaccagcgccagtgcgtgcagtacgccctgaaggcccggcccctgaggtgctac
atccccaagaacccctaccagtaccgggtgtggtacatcgtcacctcctcctacttcgag
tacctgatgttcgccctcatcatgctcaacaccatctgcctgggcatgcagcactacaac
cagtcggagcaaatgaaccacatctctgacatcctcaacgtagccttcaccatcatcttc
acactggagatggtcctcaagctcatggcgttcaaggccaggggctattttggggacccc
tggaacgtgtttgactttctgattgtcatcggcagcatcattgacgtcatcctcagtgag
atcgacactttcctggcctccagcgggggactgtattgcctgggtggcggctgcgggaac
gttgtaattccaggctgcatgagcctgccccgctcgcccaccagctctgccctgcagctt
gcatgcctgggcctggccgctggactgcatggggcagacgcgctcagggccccctgcccc
gagcaggcccccgagggtccggttgggggcgggcggagactctgtgtcaccagagtgtgc
atgggtgtggtgggacgtggggctctggcggacggaatccctgtccgcccagcgcactgc
ttggcgccccgcccaccccgcctccggctgagcaagcccagggccctgggccccgcgagg
gaagggccccgtaccgggcgcgcggtggagccctgcaccctgagccgccatcctcgcccg
caggccctgccctacgtggctctgctcatcgtcatgctcttcttcatctacgcggtcatc
ggcatgcagatgttcgggaagatcgccttggtggacgggacccagatcaaccggaacaac
aacttccagaccttcccccaggcggtgctgctgctcttcaggtgcgccacgggggaggcg
tggcaggagatcctgctggcctgcagctacggccagctgtgtgaccccgagtcggactat
gcccccggggaggagtacacctgtggcacggacttcgcctactactacttcctcagcttc
tacatgctgtgcgccttcctgatcatcaacctctttgtggccgtcatcatggacaacttt
gactacctgacacgggactggtccatcctgggccctcatcacctggatgagttcaaggcc
atctgggcggagtacgacccggaggctacgggcaggatcaagcacctggacgtggtgacc
cttctgaggaggatccagcccccgctgggcttcgggaagttctgcccccaccgggtagcg
tgtaagcggctggtgggcatgaacatgcccctcaacagcgacggcacggtcaccttcaac
gccacgctcttcgccctggtgcgcacagctctgaagatcaagacggaaggtaacttcgag
caggccaacgaggagctgcgagccatcatcaagaaggtctggaagaggaccagcatgaag
ctcctggaccaggtcatccctcccataggagatgacgaggtgacggtggggaagttctac
gccacgttcctcatccaggagcacttccggaagttcatgaggcgccaggaggagtattat
gggtaccggcccaagaaggacaccgtgcagatccaggctggactgaggaccatcgaggaa
gaggcagcccctgagatccgccgcaccatctcgggagacctgacggccgaagaggagctg
gagagagccatggtggaggccgcgatggaggaagggatcttccggaggaccggcggcctg
tttggccaggtggacagcttcctggaaaggaccaactcgttggccccgcacatggccaac
cagagacccctccagtttactgaaattgagatggaggagatagaatcgcccgtcttcctg
gaggacttccctcaaagtccgagtacccacccccttgctcgtgccaacaccaacaatgcc
aacgccaacgttgccagtggcaacggcaaccatggcaacagcccagcatttcccagtgtc
cactacgaaggggagctcgcaggggagacagagacgcctgccaccagaggaggactcttc
ggccagccccggggggccctggggccccacggcaagtcccgagtggagtggccgcaggga
cagcttccccggagaaggacgcccagggcccaggcccccgctgcctcctgccagcacgcg
ggagcagagtcccaggtgcccgaggagcagagccccaccccagggtccctgcccggggag
gcgccgcccggcagtaggacagaggacggaacccctgggggtccagctccagccatggcc
ctgctgatccgcgaggctctggttcgagggggcctggacagcttggcggcggatgctaac
ttcatcatggccacgggccaggcgctggcggaggcctgccggatggaaccgcgggaagtg
gaggtggcagccgcagagcttctgcagggacgcgagtccctggagggcgtgcctggtgcc
cgagggtgcccaggcctcgggtcctccctgggcagcctcgacctgcgtgagggctcccag
gagaccctgattccccgcaggccatga

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