KEGG   Bison bison bison (American bison): 104981967
Entry
104981967         CDS       T08726                                 
Symbol
MAPK12
Name
(RefSeq) mitogen-activated protein kinase 12
  KO
K04441  p38 MAP kinase [EC:2.7.11.24]
Organism
bbis  Bison bison bison (American bison)
Pathway
bbis01522  Endocrine resistance
bbis04010  MAPK signaling pathway
bbis04015  Rap1 signaling pathway
bbis04068  FoxO signaling pathway
bbis04071  Sphingolipid signaling pathway
bbis04114  Oocyte meiosis
bbis04148  Efferocytosis
bbis04218  Cellular senescence
bbis04261  Adrenergic signaling in cardiomyocytes
bbis04370  VEGF signaling pathway
bbis04380  Osteoclast differentiation
bbis04550  Signaling pathways regulating pluripotency of stem cells
bbis04611  Platelet activation
bbis04613  Neutrophil extracellular trap formation
bbis04620  Toll-like receptor signaling pathway
bbis04621  NOD-like receptor signaling pathway
bbis04622  RIG-I-like receptor signaling pathway
bbis04625  C-type lectin receptor signaling pathway
bbis04657  IL-17 signaling pathway
bbis04658  Th1 and Th2 cell differentiation
bbis04659  Th17 cell differentiation
bbis04660  T cell receptor signaling pathway
bbis04664  Fc epsilon RI signaling pathway
bbis04668  TNF signaling pathway
bbis04670  Leukocyte transendothelial migration
bbis04714  Thermogenesis
bbis04722  Neurotrophin signaling pathway
bbis04723  Retrograde endocannabinoid signaling
bbis04728  Dopaminergic synapse
bbis04750  Inflammatory mediator regulation of TRP channels
bbis04912  GnRH signaling pathway
bbis04914  Progesterone-mediated oocyte maturation
bbis04917  Prolactin signaling pathway
bbis04926  Relaxin signaling pathway
bbis04932  Non-alcoholic fatty liver disease
bbis04933  AGE-RAGE signaling pathway in diabetic complications
bbis04935  Growth hormone synthesis, secretion and action
bbis04936  Alcoholic liver disease
bbis05014  Amyotrophic lateral sclerosis
bbis05020  Prion disease
bbis05022  Pathways of neurodegeneration - multiple diseases
bbis05132  Salmonella infection
bbis05133  Pertussis
bbis05135  Yersinia infection
bbis05140  Leishmaniasis
bbis05142  Chagas disease
bbis05145  Toxoplasmosis
bbis05152  Tuberculosis
bbis05161  Hepatitis B
bbis05163  Human cytomegalovirus infection
bbis05167  Kaposi sarcoma-associated herpesvirus infection
bbis05169  Epstein-Barr virus infection
bbis05170  Human immunodeficiency virus 1 infection
bbis05171  Coronavirus disease - COVID-19
bbis05205  Proteoglycans in cancer
bbis05208  Chemical carcinogenesis - reactive oxygen species
bbis05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
bbis05415  Diabetic cardiomyopathy
bbis05417  Lipid and atherosclerosis
bbis05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:bbis00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    104981967 (MAPK12)
   04015 Rap1 signaling pathway
    104981967 (MAPK12)
   04370 VEGF signaling pathway
    104981967 (MAPK12)
   04668 TNF signaling pathway
    104981967 (MAPK12)
   04068 FoxO signaling pathway
    104981967 (MAPK12)
   04071 Sphingolipid signaling pathway
    104981967 (MAPK12)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    104981967 (MAPK12)
  09143 Cell growth and death
   04114 Oocyte meiosis
    104981967 (MAPK12)
   04218 Cellular senescence
    104981967 (MAPK12)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    104981967 (MAPK12)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    104981967 (MAPK12)
   04613 Neutrophil extracellular trap formation
    104981967 (MAPK12)
   04620 Toll-like receptor signaling pathway
    104981967 (MAPK12)
   04621 NOD-like receptor signaling pathway
    104981967 (MAPK12)
   04622 RIG-I-like receptor signaling pathway
    104981967 (MAPK12)
   04625 C-type lectin receptor signaling pathway
    104981967 (MAPK12)
   04660 T cell receptor signaling pathway
    104981967 (MAPK12)
   04658 Th1 and Th2 cell differentiation
    104981967 (MAPK12)
   04659 Th17 cell differentiation
    104981967 (MAPK12)
   04657 IL-17 signaling pathway
    104981967 (MAPK12)
   04664 Fc epsilon RI signaling pathway
    104981967 (MAPK12)
   04670 Leukocyte transendothelial migration
    104981967 (MAPK12)
  09152 Endocrine system
   04912 GnRH signaling pathway
    104981967 (MAPK12)
   04914 Progesterone-mediated oocyte maturation
    104981967 (MAPK12)
   04917 Prolactin signaling pathway
    104981967 (MAPK12)
   04926 Relaxin signaling pathway
    104981967 (MAPK12)
   04935 Growth hormone synthesis, secretion and action
    104981967 (MAPK12)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    104981967 (MAPK12)
  09156 Nervous system
   04728 Dopaminergic synapse
    104981967 (MAPK12)
   04723 Retrograde endocannabinoid signaling
    104981967 (MAPK12)
   04722 Neurotrophin signaling pathway
    104981967 (MAPK12)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    104981967 (MAPK12)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    104981967 (MAPK12)
  09159 Environmental adaptation
   04714 Thermogenesis
    104981967 (MAPK12)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    104981967 (MAPK12)
   05208 Chemical carcinogenesis - reactive oxygen species
    104981967 (MAPK12)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    104981967 (MAPK12)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    104981967 (MAPK12)
   05161 Hepatitis B
    104981967 (MAPK12)
   05171 Coronavirus disease - COVID-19
    104981967 (MAPK12)
   05163 Human cytomegalovirus infection
    104981967 (MAPK12)
   05167 Kaposi sarcoma-associated herpesvirus infection
    104981967 (MAPK12)
   05169 Epstein-Barr virus infection
    104981967 (MAPK12)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    104981967 (MAPK12)
   05135 Yersinia infection
    104981967 (MAPK12)
   05133 Pertussis
    104981967 (MAPK12)
   05152 Tuberculosis
    104981967 (MAPK12)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    104981967 (MAPK12)
   05140 Leishmaniasis
    104981967 (MAPK12)
   05142 Chagas disease
    104981967 (MAPK12)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    104981967 (MAPK12)
   05020 Prion disease
    104981967 (MAPK12)
   05022 Pathways of neurodegeneration - multiple diseases
    104981967 (MAPK12)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    104981967 (MAPK12)
   05418 Fluid shear stress and atherosclerosis
    104981967 (MAPK12)
   05415 Diabetic cardiomyopathy
    104981967 (MAPK12)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    104981967 (MAPK12)
   04932 Non-alcoholic fatty liver disease
    104981967 (MAPK12)
   04933 AGE-RAGE signaling pathway in diabetic complications
    104981967 (MAPK12)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    104981967 (MAPK12)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:bbis01001]
    104981967 (MAPK12)
Enzymes [BR:bbis01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     104981967 (MAPK12)
Protein kinases [BR:bbis01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   104981967 (MAPK12)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Kdo APH Kinase-like Haspin_kinase
Other DBs
NCBI-GeneID: 104981967
NCBI-ProteinID: XP_010829534
UniProt: A0A6P3GRP7
LinkDB
Position
Unknown
AA seq 433 aa
MGGACLDATTASGTQPRPGTPVLTLRLLGNLLVCGRLHGLLEVGGAQGFAKSLLGGMQGA
QVATGTPVGSLQDHPLCSSVEVTKTAWEVRVVYQDLQPVGSGAYGAVCSAVDSRTGAKVA
IKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFMDFYLVMPFMGT
DLGKLMKHEKLSEDRVQFLVYQTLKGLKYIHAAGVIHRDLKPSNLAVNEDCELKILDFGL
ARQADSEMTGYVVTRWYRAPEVILNWMHYTQTVDIWSVGCIMAEMITGKTLFKGNDHLDQ
LKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASVLTNASPLAVSLLEKMLVL
DAERRVTAAEALAHPYFESLHDTEDDPQAEKYDESFDDMDRTLDEWKRVTYKEVLSFKPP
RQLGAKVSKETAL
NT seq 1302 nt   +upstreamnt  +downstreamnt
atggggggcgcctgccttgacgccactacagccagtggcacccagccccggcctgggacc
cccgtcctcacgctgcgccttctggggaacctgctcgtgtgtggacgcctgcacgggctc
ctcgaggtgggtggggcgcaaggctttgctaagagcctgctgggcggcatgcaaggggct
caggtggccacaggcacccctgtggggagcctgcaggaccaccctctctgctccagcgtg
gaggtgaccaagacggcctgggaggtgcgcgtcgtgtaccaggatctgcagcccgtgggc
tcgggcgcctacggcgccgtgtgctcggcggtggacagccgcacgggcgccaaggtggcc
atcaagaagctgtaccggccctttcagtccgagctgttcgccaagcgcgcctaccgggag
ctgcgcctcctgaagcacatgcgccacgagaacgtgattgggctgctggacgtgttcacg
cccgatgagacgctggatgacttcatggacttctacctggtgatgccgttcatgggcacc
gacctgggaaagctcatgaagcacgagaagctgagcgaggaccgggtgcagttcctcgtc
taccagacgctcaaggggctgaagtacatccacgctgccggcgtcatccacagggacctg
aagcctagcaacctggctgtgaacgaggactgtgagctgaagatcctggactttggcctg
gcccggcaggcagacagcgagatgaccggctacgtggtgacccggtggtaccgcgcgccc
gaggtcatcttgaactggatgcactacacgcagacggtggacatctggtccgtgggctgc
atcatggccgagatgatcacggggaagacactcttcaaaggcaacgaccacctggaccag
ctgaaggagatcatgaaggtgacggggacgcctcccgcggagtttgtgcagaggctgcaa
agtgatgaggccaagaactacatgaagggcctccctgagctggagaagaaggattttgcc
tccgtcctgaccaacgcgagccccctggccgtgagcctcctggagaaaatgctggtgctg
gatgcggagcggcgggtgacggcggccgaggcgctggcccacccctactttgagtcgctg
cacgacacggaggacgatccccaggccgagaagtacgatgagtcctttgacgacatggac
cgcacgctggacgagtggaagcgtgtcacatataaagaggtgctcagcttcaagcctccc
cggcagctgggggccaaggtctccaaggagacagccttgtga

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