KEGG   Bison bison bison (American bison): 104984484
Entry
104984484         CDS       T08726                                 
Symbol
PLCB4
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
bbis  Bison bison bison (American bison)
Pathway
bbis00562  Inositol phosphate metabolism
bbis01100  Metabolic pathways
bbis04015  Rap1 signaling pathway
bbis04020  Calcium signaling pathway
bbis04022  cGMP-PKG signaling pathway
bbis04062  Chemokine signaling pathway
bbis04070  Phosphatidylinositol signaling system
bbis04071  Sphingolipid signaling pathway
bbis04072  Phospholipase D signaling pathway
bbis04081  Hormone signaling
bbis04082  Neuroactive ligand signaling
bbis04261  Adrenergic signaling in cardiomyocytes
bbis04270  Vascular smooth muscle contraction
bbis04310  Wnt signaling pathway
bbis04371  Apelin signaling pathway
bbis04540  Gap junction
bbis04611  Platelet activation
bbis04613  Neutrophil extracellular trap formation
bbis04621  NOD-like receptor signaling pathway
bbis04713  Circadian entrainment
bbis04720  Long-term potentiation
bbis04723  Retrograde endocannabinoid signaling
bbis04724  Glutamatergic synapse
bbis04725  Cholinergic synapse
bbis04726  Serotonergic synapse
bbis04728  Dopaminergic synapse
bbis04730  Long-term depression
bbis04742  Taste transduction
bbis04750  Inflammatory mediator regulation of TRP channels
bbis04911  Insulin secretion
bbis04912  GnRH signaling pathway
bbis04915  Estrogen signaling pathway
bbis04916  Melanogenesis
bbis04918  Thyroid hormone synthesis
bbis04919  Thyroid hormone signaling pathway
bbis04921  Oxytocin signaling pathway
bbis04922  Glucagon signaling pathway
bbis04924  Renin secretion
bbis04925  Aldosterone synthesis and secretion
bbis04926  Relaxin signaling pathway
bbis04927  Cortisol synthesis and secretion
bbis04928  Parathyroid hormone synthesis, secretion and action
bbis04929  GnRH secretion
bbis04933  AGE-RAGE signaling pathway in diabetic complications
bbis04934  Cushing syndrome
bbis04935  Growth hormone synthesis, secretion and action
bbis04961  Endocrine and other factor-regulated calcium reabsorption
bbis04970  Salivary secretion
bbis04971  Gastric acid secretion
bbis04972  Pancreatic secretion
bbis04973  Carbohydrate digestion and absorption
bbis05010  Alzheimer disease
bbis05016  Huntington disease
bbis05017  Spinocerebellar ataxia
bbis05022  Pathways of neurodegeneration - multiple diseases
bbis05142  Chagas disease
bbis05143  African trypanosomiasis
bbis05146  Amoebiasis
bbis05163  Human cytomegalovirus infection
bbis05200  Pathways in cancer
bbis05415  Diabetic cardiomyopathy
bbis05417  Lipid and atherosclerosis
Module
bbis_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:bbis00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    104984484 (PLCB4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    104984484 (PLCB4)
   04310 Wnt signaling pathway
    104984484 (PLCB4)
   04371 Apelin signaling pathway
    104984484 (PLCB4)
   04020 Calcium signaling pathway
    104984484 (PLCB4)
   04070 Phosphatidylinositol signaling system
    104984484 (PLCB4)
   04072 Phospholipase D signaling pathway
    104984484 (PLCB4)
   04071 Sphingolipid signaling pathway
    104984484 (PLCB4)
   04022 cGMP-PKG signaling pathway
    104984484 (PLCB4)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    104984484 (PLCB4)
   04081 Hormone signaling
    104984484 (PLCB4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    104984484 (PLCB4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    104984484 (PLCB4)
   04613 Neutrophil extracellular trap formation
    104984484 (PLCB4)
   04621 NOD-like receptor signaling pathway
    104984484 (PLCB4)
   04062 Chemokine signaling pathway
    104984484 (PLCB4)
  09152 Endocrine system
   04911 Insulin secretion
    104984484 (PLCB4)
   04922 Glucagon signaling pathway
    104984484 (PLCB4)
   04929 GnRH secretion
    104984484 (PLCB4)
   04912 GnRH signaling pathway
    104984484 (PLCB4)
   04915 Estrogen signaling pathway
    104984484 (PLCB4)
   04921 Oxytocin signaling pathway
    104984484 (PLCB4)
   04926 Relaxin signaling pathway
    104984484 (PLCB4)
   04935 Growth hormone synthesis, secretion and action
    104984484 (PLCB4)
   04918 Thyroid hormone synthesis
    104984484 (PLCB4)
   04919 Thyroid hormone signaling pathway
    104984484 (PLCB4)
   04928 Parathyroid hormone synthesis, secretion and action
    104984484 (PLCB4)
   04916 Melanogenesis
    104984484 (PLCB4)
   04924 Renin secretion
    104984484 (PLCB4)
   04925 Aldosterone synthesis and secretion
    104984484 (PLCB4)
   04927 Cortisol synthesis and secretion
    104984484 (PLCB4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    104984484 (PLCB4)
   04270 Vascular smooth muscle contraction
    104984484 (PLCB4)
  09154 Digestive system
   04970 Salivary secretion
    104984484 (PLCB4)
   04971 Gastric acid secretion
    104984484 (PLCB4)
   04972 Pancreatic secretion
    104984484 (PLCB4)
   04973 Carbohydrate digestion and absorption
    104984484 (PLCB4)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    104984484 (PLCB4)
  09156 Nervous system
   04724 Glutamatergic synapse
    104984484 (PLCB4)
   04725 Cholinergic synapse
    104984484 (PLCB4)
   04728 Dopaminergic synapse
    104984484 (PLCB4)
   04726 Serotonergic synapse
    104984484 (PLCB4)
   04720 Long-term potentiation
    104984484 (PLCB4)
   04730 Long-term depression
    104984484 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    104984484 (PLCB4)
  09157 Sensory system
   04742 Taste transduction
    104984484 (PLCB4)
   04750 Inflammatory mediator regulation of TRP channels
    104984484 (PLCB4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    104984484 (PLCB4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    104984484 (PLCB4)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    104984484 (PLCB4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    104984484 (PLCB4)
   05142 Chagas disease
    104984484 (PLCB4)
   05143 African trypanosomiasis
    104984484 (PLCB4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    104984484 (PLCB4)
   05016 Huntington disease
    104984484 (PLCB4)
   05017 Spinocerebellar ataxia
    104984484 (PLCB4)
   05022 Pathways of neurodegeneration - multiple diseases
    104984484 (PLCB4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    104984484 (PLCB4)
   05415 Diabetic cardiomyopathy
    104984484 (PLCB4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    104984484 (PLCB4)
   04934 Cushing syndrome
    104984484 (PLCB4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:bbis04131]
    104984484 (PLCB4)
Enzymes [BR:bbis01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     104984484 (PLCB4)
Membrane trafficking [BR:bbis04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    104984484 (PLCB4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    104984484 (PLCB4)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 PLC-beta_C EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 104984484
NCBI-ProteinID: XP_010832526
Ensembl: ENSBBBG00000012455
UniProt: A0A6P3GLX3
LinkDB
Position
Unknown
AA seq 1206 aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVL
ECSLINSVRLGATPKDPKILAALEALGKSENDLEGRIVCVCSGADLVNISFTYMVAENPE
ITKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKQGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEALKSM
MEAGESAAPVNILEDDNEEEIESAEQEEEAHPEYKYGNELSADDLGHKEAIANSVKKASD
DLEHENSKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNI
HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS
LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI
SGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLA
VLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGF
GDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQ
SSSELRPTTTAALGAGLEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELSSLKKKHAK
EHSTMQKLHCTQVDKIVAQYDKEKLTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSD
HKSKVKEIVAQHTKEWSDMINTHSAEEQEIRDLHLSQQCELLRKLLISAHEQQTQQLKLS
HDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMK
QSKEMDQLKKVQLEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEIGSRDGPQTSNSCV
KLQDTN
NT seq 3621 nt   +upstreamnt  +downstreamnt
atggccaaaccttatgaatttaattggcagaaggaagttccttcctttttgcaagaagga
gcagtttttgacagatatgaagaggaatcctttgtgtttgaacccaactgcctcttcaaa
gtagatgaatttggcttctttctgacctggagaagtgaaggcaaggaaggccaagtgtta
gaatgctccctcatcaacagtgttcgtctgggagccacaccgaaggatcccaaaattttg
gctgctcttgaagctcttggcaaatcagaaaatgatctggaagggcggatagtttgcgtc
tgcagtggtgcagatctggtgaacatcagtttcacgtacatggtggctgaaaatccagaa
ataactaagcaatgggtcgaaggcctgagatccatcattcacaacttcagggccaacaac
gtcagcccgatgacgtgcctcaagaagcactggatgaaattggcatttatgaccaacaca
aatgggaaaattccagttaggagtattactagaacctttgcatcggggaaaacagaaaag
gtgatctttcaagcactcaaggagctaggtcttcccagtggaaagaatgatgaaattgag
cctgccgcatttacttatgaaaagttctatgaactgacacaaaagatttgtcctcggaca
gatatagaggatcttttcaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcaacgagatcctcgactgaatgaaattttattc
ccattttatgatgctaaaagggcaatgcagatcattgagatgtatgagcccgatgaagat
ttgaagaaacaaggcctcatatcaagtgatgggttttgcagatacctgatgtcagatgaa
aacgcccccgtcttcctagatcgtctagagctgtaccaagaaatggaccaccctctggct
cactacttcatcagctcttcccacaacacctatctcactggcagacagtttggtgggaaa
tcttcagtagaaatgtacagacaggtcctcctggctggttgcagatgtgttgaacttgac
tgttgggatggaaaaggtgaggaccaggaaccgataataactcacgggaaagcaatgtgc
acagatatcctttttaaggatgttattcaagccatcaaggaaactgcctttgtcacatcg
gaatatcctgtaattctctcctttgaaaatcactgcagcaaatatcaacagtacaagatg
tccaaatactgtgaagatctatttggagatctcctgttgaaacaagcacttgaatcacat
ccactggaaccaggcagacccttgccatccccaaatgacctcaaaagaaaaatactcatc
aaaaacaaacgactgaaacccgaggttgaaaaaaaacagcttgaagctttgaaaagcatg
atggaagccggagaatccgctgccccggtgaacatcttagaggatgacaatgaagaggaa
atagaaagtgctgagcaagaggaggaagcccaccctgaatacaaatatggaaatgaactt
tctgcagatgacttgggtcacaaggaagctattgccaatagtgtcaagaaggcttcagat
gaccttgaacatgaaaacagcaaaaagggcctggttaccgtagaagatgagcaggcgtgg
atggcatcttataaatatgtgggtgctaccactaatatccatccgtatttgtccacaatg
atcaactatgcacagcctgtaaagtttcaaggtttccatgtggctgaagaacgcaatatt
cattataacatgtcttcctttaatgagtcagtcggtctaggctacttgaagacacacgcc
attgaatttgtgaattataataaacggcaaatgagtcgcatttaccccaagggaggccga
gtggactccagtaattacatgcctcagattttctggaacgctggctgccagatggtttcg
ctgaactatcaaaccccagatttagcgatgcagttgaatcaggggaaatttgagtataat
ggatcgtgtgggtaccttctcaaaccagatttcatgagacggcctgatcgaacatttgat
cctttctctgaaacgcctgttgatggggttattgcagccacttgctccgtacaggtcata
tcaggtcagttcttatcagataagaaaattggcacatatgtagaagtggatatgtatggg
ctgcccacggacactatccggaaggagttccgcactcgcatggtgatgaacaacggactc
aatccggtttacaatgaagaatcatttgtgtttcggaaggtgatcctccccgacctggct
gtcttgaggatcgccgtgtatgatgacaacaacaagctgatcggccagaggattctgccc
ctggatggcctccaagcaggctatcgacacatatccctccggaatgagggaaataaacct
ttatcactgccaaccattttctgcaatattgtcctaaaaacatatgtgcctgatggattc
ggagatattgtggatgctttatcagatccaaagaaatttctttccattacggaaaagaga
gcggatcaaatgagagctatgggcattgaaactagtgacattgccgatgtgcccagtgac
acttcaaagaacgacaagaaagggaaagccaacacagccaaagcgaatgtgacccctcag
agcagctcagagctcaggccaaccaccacagctgccctgggggctggcctggaggccaag
aaaggtattgaactgatccctcaagtgaggatagaagatttaaagcagatgaaggcttac
ttgaagcatttaaagaaacaacagaaagagctcagttctttaaagaagaaacatgcaaag
gagcacagtaccatgcagaaactccattgcactcaagttgacaagattgtggcacagtac
gacaaggagaaattgactcacgagaaaatcctagagaaggcaatgaagaagaaaggggga
agtaattgtcttgaaatgaagaaagaaacagaaattaaaattcagacgctgacatcagat
cacaaatctaaggtcaaggagattgtggcacagcacacaaaggagtggtcagacatgatc
aacacccacagtgcggaggagcaggagatccgggacctgcacctcagccagcagtgcgag
ctgctcagaaagctcctgatcagcgcccacgagcagcagacccagcagctgaaactgtcc
catgacagggaaagcaaagagatgcgagcacaccaagctaagatttctatggaaaatagc
aaagccatcagccaagataaatccatcaagaataaagcagaacgggaaaggagagtcagg
gagttaaacagcagcaacactaaaaagtttctggaagaaagaaagcgactcgccatgaag
cagtccaaagaaatggatcagttgaaaaaagtccagcttgagcacctcgaattcctagag
aaacagaatgagcagcttttgaaatcctgtcacgcagtgtcccaaacgcaaggcgaagga
gatgcagcagatggtgaaattggaagccgagatggaccgcagaccagcaacagttgtgtg
aaactccaggacacaaactga

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