Bison bison bison (American bison): 104988726 Help Entry 104988726         CDS       T08726                                  Symbol JAK1 Name (RefSeq) tyrosine-protein kinase JAK1   KO K11217   Janus kinase 1 [EC:2.7.10.2] Organism bbis  Bison bison bison (American bison) Pathway bbis01521   EGFR tyrosine kinase inhibitor resistance bbis04151   PI3K-Akt signaling pathway bbis04217   Necroptosis bbis04380   Osteoclast differentiation bbis04550   Signaling pathways regulating pluripotency of stem cells bbis04620   Toll-like receptor signaling pathway bbis04621   NOD-like receptor signaling pathway bbis04630   JAK-STAT signaling pathway bbis04658   Th1 and Th2 cell differentiation bbis04659   Th17 cell differentiation bbis05140   Leishmaniasis bbis05145   Toxoplasmosis bbis05152   Tuberculosis bbis05160   Hepatitis C bbis05161   Hepatitis B bbis05162   Measles bbis05163   Human cytomegalovirus infection bbis05164   Influenza A bbis05165   Human papillomavirus infection bbis05166   Human T-cell leukemia virus 1 infection bbis05167   Kaposi sarcoma-associated herpesvirus infection bbis05168   Herpes simplex virus 1 infection bbis05169   Epstein-Barr virus infection bbis05171   Coronavirus disease - COVID-19 bbis05200   Pathways in cancer bbis05203   Viral carcinogenesis bbis05212   Pancreatic cancer bbis05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:bbis00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     104988726 (JAK1)    04151 PI3K-Akt signaling pathway     104988726 (JAK1)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     104988726 (JAK1)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     104988726 (JAK1)  09150 Organismal Systems   09151 Immune system    04620 Toll-like receptor signaling pathway     104988726 (JAK1)    04621 NOD-like receptor signaling pathway     104988726 (JAK1)    04658 Th1 and Th2 cell differentiation     104988726 (JAK1)    04659 Th17 cell differentiation     104988726 (JAK1)   09158 Development and regeneration    04380 Osteoclast differentiation     104988726 (JAK1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     104988726 (JAK1)    05203 Viral carcinogenesis     104988726 (JAK1)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     104988726 (JAK1)   09162 Cancer: specific types    05212 Pancreatic cancer     104988726 (JAK1)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     104988726 (JAK1)    05161 Hepatitis B     104988726 (JAK1)    05160 Hepatitis C     104988726 (JAK1)    05171 Coronavirus disease - COVID-19     104988726 (JAK1)    05164 Influenza A     104988726 (JAK1)    05162 Measles     104988726 (JAK1)    05168 Herpes simplex virus 1 infection     104988726 (JAK1)    05163 Human cytomegalovirus infection     104988726 (JAK1)    05167 Kaposi sarcoma-associated herpesvirus infection     104988726 (JAK1)    05169 Epstein-Barr virus infection     104988726 (JAK1)    05165 Human papillomavirus infection     104988726 (JAK1)   09171 Infectious disease: bacterial    05152 Tuberculosis     104988726 (JAK1)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     104988726 (JAK1)    05140 Leishmaniasis     104988726 (JAK1)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     104988726 (JAK1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:bbis01001]     104988726 (JAK1) Enzymes [BR:bbis01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      104988726 (JAK1) Protein kinases [BR:bbis01001]  Non-receptor tyrosine kinases   JAK family [OT]    104988726 (JAK1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase Jak1_Phl FERM_F2 SH2_1 FERM_F1 ABC1 SH2 RIO1 FERM_C_FAK1 Motif Other DBs NCBI-GeneID:  104988726 NCBI-ProteinID:  XP_010838464 Ensembl:  ENSBBBG00000008822 UniProt:  A0A6P3HH43 LinkDB All DBs Position Unknown AA seq 1158 aa AA seqDB search MQYLNIKEDCSAMAFCAKMRSSKKAEMNLEAPEPGVEVLFYLSDREPLRLGGGEYTAEEL CIRAAQECCISPLCHNLFALYDENTKLWYAPNRTVTVDDKTSLRLHYRMRFFATPWTGAH DNEQSVWRHSPKKQKNGYEKKKVPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQ DGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMN RFHPNDSGNVLCYEVMVTGNLGIQWRQKPHIVPVEKEKNKLKRKKLENKHKKDEEKNKIR EEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAH HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVT CFEKSEVLGIQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFVLK RCCQPKPREISNLLVATKKAQEWQPVYTMSQLSFDRILKKDITQGEHLGRGTRTHIYSGT LTDYKDDEGTSEEKRIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDV ENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLL LAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGT TLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAI MRDINKLEEQNPDIVSEKKPTTEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNT GEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPS GSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGD FGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSD SSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQHMRKCWEFQPSNRTT FQNLIEGFEALLRSMSNI NT seq 3477 nt NT seq  +upstreamnt  +downstreamnt atgcagtatctaaatataaaagaggactgcagtgccatggctttctgtgctaaaatgagg agctccaagaaggcggagatgaatctggaggcccctgagccgggggtggaggtgctcttc tacctgtcggatagggagcctctccggctgggcggtggagagtacacggcggaggagctg tgcattcgggcggcgcaggagtgctgtatctctcctctgtgtcacaacctctttgccctg tatgacgagaacaccaagctctggtatgctccgaatcgcaccgtcaccgtcgacgacaaa acgtcactccggcttcactaccggatgaggttctttgctaccccatggactggggcccac gacaatgaacaatcagtatggcgacattctccaaagaagcagaaaaacggctatgagaaa aaaaaagttccagatgcaacacctctccttgacgccagctcgctggagtatctgtttgct cagggacagtatgatttggtcaaatgcctggctcccattcgagaccccaagacggagcag gatgggcacgacattgagaacgagtgtcttgggatggccgtgctggccatctcccactac gccatgatgaagaagatgcaattgccagaactccccaaggacatcagctacaagcgatat attccagaaacattgaataagtccatcagacagaggaaccttctcaccaggatgcggata aataatgttttcaaggattttctaaaggagtttaacaacaagaccatttgtgacagcagc gtgtccacgcacgacctgaaggtgaaatacctggctaccttggaaactttgacaaaacat tatggtgctgaaatatttgagacttccatgctactgatttcatcagaaaatgagatgaat cggttccatccaaatgatagtggaaatgttctctgctatgaagtgatggtgactggaaat cttggaatccagtggagacagaaaccacatattgttcctgttgaaaaggaaaaaaacaaa ctgaaacggaaaaaactggaaaataaacacaagaaggatgaggaaaaaaacaaaatccga gaagagtggaacaatttttcttacttccctgagatcactcacattgtaatcaaggagtct gtggtcagcattaataagcaggacaacaaaaaaatggaactgaagctctcttcccacgag gaggccttgtccttcgtgtccctggtcgatggctacttccggctcacggcagacgcccat cactacctctgcactgacgtggctcccccattgatcgtccacaacatacagaatggctgt catggtccaatctgcacggagtatgccatcaataagctgcggcaggaggggagcgaggag gggatgtacgtgctgcggtggagctgcaccgactttgacaacatcctcatgaccgtcacc tgcttcgaaaagtctgaggtgctgggtatccagaaacagttcaagaactttcagatcgag gtgcagaagggccgctacagcctgcatggctcggaccgcagcttcccgagccttggggac ctcatgagccacctaaagaagcagatcctgcgcacggacaacatcagcttcgtgctgaag cgctgctgccagcccaagccccgagaaatctccaatctgctggtggccaccaagaaagcc caggagtggcagcctgtctacaccatgagccagctgagtttcgatcgaatcctcaagaaa gatattacgcaaggcgagcaccttgggagaggcacgcggacacacatctactctgggacc ctcacggattacaaggatgacgaagggacttctgaagagaagagaataaaagtcatcctg aaggtcttagaccccagccacagggacatttctctggccttctttgaggcagccagcatg atgaggcaggtctcccacaaacacatcgtgtacctctatggggtttgcgtccgagatgtg gagaatatcatggtggaagagtttgtggaggggggacccctggacctcttcatgcatcgg aaaagtgacgtcctcaccacaccctggaagtttaaagttgccaaacagctggccagcgcc ctgagttacttggaggataaagacctggtccacggaaatgtgtgcactaaaaacctcctt ctggcccgcgagggcatcgacagtgagtgcggccccttcatcaagctcagtgaccctggc atccccatcactgtgctctccaggcaagagtgcatagaacgaatcccctggattgctccc gagtgtgttgaagactccaagaatctgagtgtggctgctgacaagtggagctttggaacc acactctgggaaatctgctacaatggcgagatccccttgaaagacaagacgctgattgag aaagagagattctatgaaagccggtgcaggccagtgaccccatcttgtaaggagctagct gacttgatgacccgctgcatgaactacgaccccaaccagagacccttcttccgagccatc atgagagacatcaataagctggaggagcagaatccagacattgtatcagaaaaaaagcca acaactgaagtggatcccacacattttgaaaagcggttcttaaagaggatccgtgacttg ggagagggccactttgggaaggtcgagctctgcaggtatgaccctgagggggacaataca ggggagcaagtggctgtcaaatccctgaagcccgagagtggagggaaccacatcgctgat ctgaagaaggagattgaaatcttaagaaatctttatcatgagaacattgtgaagtataaa ggcatctgcacagaagatggtggaaatggtattaagctcatcatggagtttctgccttca gggagccttaaggaatatcttccaaagaataagaacaaaattaacctcaaacagcaatta aaatatgccgttcagatttgtaaggggatggactatctgggttctcggcagtacgttcac cgggacttagcagcaagaaacgtcctcgtggagagtgagcaccaggtgaaaatcggggac ttcggtctcaccaaagccatcgaaactgataaggagtactacacagtcaaggacgaccgg gacagccctgtgttttggtatgctccagaatgtttaattcagtgtaagttctatatcgcc tctgatgtctggtctttcggagtgactctgcatgagctgcttacttactgtgattcagat tccagtcccatggccttgttcctgaaaatgataggcccaactcatggtcagatgacggta acaagactcgtgaatacattaaaagaaggaaaacgcttgccatgtccaccgaactgtcca gatgaggtttatcaacatatgcgaaagtgttgggaatttcaaccatctaatcggacaacc tttcagaaccttattgaaggatttgaagcacttctaagaagcatgagtaacatttaa

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