Bison bison bison (American bison): 104989018 Help Entry 104989018         CDS       T08726                                  Symbol APOB Name (RefSeq) apolipoprotein B-100   KO K14462   apolipoprotein B Organism bbis  Bison bison bison (American bison) Pathway bbis04975   Fat digestion and absorption bbis04977   Vitamin digestion and absorption bbis04979   Cholesterol metabolism bbis05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:bbis00001]  09150 Organismal Systems   09154 Digestive system    04975 Fat digestion and absorption     104989018 (APOB)    04979 Cholesterol metabolism     104989018 (APOB)    04977 Vitamin digestion and absorption     104989018 (APOB)  09160 Human Diseases   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     104989018 (APOB)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:bbis04147]     104989018 (APOB)    00536 Glycosaminoglycan binding proteins [BR:bbis00536]     104989018 (APOB) Exosome [BR:bbis04147]  Exosomal proteins   Exosomal proteins of other cancer cells    104989018 (APOB) Glycosaminoglycan binding proteins [BR:bbis00536]  Heparan sulfate / Heparin   Others    104989018 (APOB) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Vitellogenin_N Vit_open_b-sht DUF1081 ApoB100_C CstA Csa3_N Motif Other DBs NCBI-GeneID:  104989018 NCBI-ProteinID:  XP_010838839 Ensembl:  ENSBBBG00000019104 UniProt:  A0A6P3HI87 LinkDB All DBs Position Unknown AA seq 4568 aa AA seqDB search MGAPRPAVLLLLLLLFLDAANAQARDEVLENVSPSCPKDAMRFKHLRKYVYNYEAESSSG VPGTADSRSTTKINCKVELEVPQLCNFILKTSDCTLKEVDGLNPEGKELLKKTKNSEEFA AAMSKYDLKLAVPEGKQVLLYPEKEEPKHILNIKRGIISALLLPPETEEAKQVLFLDTVY GNCSTDFTVKTKTGNVATEISIERNLEKCDHFQPISTGVSPLALIRGMTRPLSTLIGSSQ SCRYTLDPRKKHVSEAICNEQHLFLPFSYKNKYGMMAQVTQTLKLENTPKINSRFFEEGT EAVGLAFESTRSTSPPNHAEAIVKTLQELQKLHVSEQNAQRANLFHKLVTELRGLSSEAV TSLLPKLIEVSSPITLQALIQCGQPQCYTHILQCLKNERANPLLIDAVTYLVALIPEPSA ERLQEVFNTARVQQSRLTFYALSHMINNYHKTNPTWTQDLLEIADYLSEQIGNDCTGNED LTYLILRVIGNIGKTMEQLTPKLTSSVLKCIRSEQPSLVIQKAAIQALRKMELSDEVREV LLQTFLDDTSPGDKRLAAYLMLMGSPSQSDISKITQLLPGEQNEQVKNFVASHIANILNS EDLYVQDLKSLVEEALKKSQLPTIMDFKKFSRSYQFSKLISLPSLDLVSAKIEGNLIFDP NNYLPKESMLKTTLKVFGFASADLFEIGLEGKGFEPTLEALFGKEGFFPDSVNKALYWVN GRVPDRVSKVLVDHFGYTKDDKHEQDMVNGVMFNVEKLVKDLKSKDFPEARAYLRILGEE LGFVKLHDLQLLGKLLLKGVRTLQGIPQMIKELIRKGSTSDLFLHYIFMDNAFELPTGLG LQLQVSSSGIITPGIKAGVKLEVADMQAELVTKPSVSVEFVTNMGIVIPDFARSGVQMNT NFFHETGLEARVVLKAGQLKFIIPSPKRPVRLFSGSNTLHLVSTTKTEVIPPLIENRQSW STCKPFFIGLNYCITGAYSNASSTDSSSYYPLTGDTRFELELKPTGEVEQYSAKAFYELR RDGEALVDMLKLVTQTEGVKQTEATLLFRYNRQSKTLSSELHIPDFDIDLGTVLKVNYEH SKEKKSYKLTLDFQNKKITEVTLTGHISYDRKEEGKIKGVISIPRLQAEARSEILSLWSP SKLLLQMDSSATAYGSTISKKVAWRYDGDKIEFEWNTGTNVDTKKATSNFPVDLSAFPKS LHTYANILLDRRVPQTDLTFRHMGSKLVAAASTWLQETSRSLPYAQNIQDQLSGLQELCL QKMELPNVHIPDNLFLKSDGRIKYTLNKNSMEIEIPLPFGGKSSEDLKMFKTIQTPALNF QPLGFHLPSQEFQIPTFTIPNLYPLRLPLLGVLDLSTSIYSNLYNWSASYTGGNTSTDHW SLQAQYHVKADSVVNLLSYHVQGSGKTAYDHRNTLTFSGDGSLHHKFLDSNVKFSHVEKR GNSPASEGLLTFDASSAWGPQISASVHLDSKKKEHLYVKEVKIDGQLRASAFYAKGVYDL SYQRDPATGQLTGESNLRFNSSYVQGTNQITGRYDDGTVSITSTSDLQDGLVKNTASLKY ENYELTVKSDTNGKYEDFATSNKVDLTFSKQHALLRSEYQADYKALRFFTLLSGSLNSHG LELNADILGTDKINSGAHKATLRIARDGMSTSATTSLKYNPLVLENELNAAVSLSGASLK LTSNGRFREHHAKFSLDGKAAPTELSLGSAYQAMILGVDSKNIFHFKINQEGLKLSNDIM GSYDEMKLDYTNNLNIVGFSLDFSSKLDNIYSSDKFYKQNFNLQLEPYSLVTTLNSDLKF SALDMTNNGKLRLEPLKLNVGGTIKGAYQNDEIKHIYTLSYADLSASYKADTVAKVQGTE FSHRLNTNIAGLASTVDIRTNYNSDSLHFSNAFHSAVAPFTMTIDTHTNGNGELVLWGQH TGQLYSKFLLKAEPLAFTFSHDYRGSTSHRLMSKRSITTALDHKVSALLTLAEQTGDWKL RTQLNQNEYSQDFSAYNTKDKAGVELSGRALADLTVLDFPIAVPLVLNEPINVIDTFEMR DSVGQPQEFTLVASVKYDKNQNAHTIHLPFFKFLPKYFEKTRVVVIGALETVQKELKRTH IDKHMRKYVEALDRLSQQVSDYLSTFNWERQVLSAKEKLTAFTENDLQIVLDNATINLNE KLSQLQTYVIQFDQYFEDNYDLHDFKTTIAKIIDQIIEKLKILDEHYHIRVNLVKKIRDL YFFIENFDFNKTESSTASWIQNMDTKYQIRIQIQEKLQQLKVQIQTVDIHHLAEMFKQQV EAVDVRVLLDQLRTTIPFQRIKEIIEHVKYRVTSLSEGFKVTEEINAFRVMVHEFIKMYK IDQHIQALMDKSVQLAQQYKLQETVQKLSSVLQQVKMAEIVEKLIGLTDNALKQLEALSF NQFLEEVNRFLDMLVKKLRSFDYHQFVDETNNKIHEVTQRINDEIQALEFPQKAKALRLL VEDARIVVSTYLENLKATKITLVLDWLQEALSSTSVTYMKAKFQETLEDFRDRVYQMDVQ QELQRYLFLVGQVYNTLVTYISDWWALAAKNLTDFAEQYSIQDWAENLKTLVEQGFTVPE IQTTFGTIPAFKIGLRALQEATYQTPDFIVPLTDLRIPSFQINFKTLKDVKIPSSFSTPE FTILNTLHIPSFTIDFVEIKIKIVRTIDQMLNSELQWPVPEVYLGDLSGVDTILAGITVP DFHLPEITIPEFVIPNLNLTDFQVSDLHIPEFQLPHISRTVEVPAFGKLYSILKIQSPFF TLDANADIQNATALANQAEMEASITAKGASRLEVLNFDFQAKAQLSDPTLNPLVLKESVR FSSKYLKTEHESEVLWVGNAIEGKSNTVAGIHTEKNTLELSSSVLVNISNQLTLDSNTKY FHKLNIPQLDFSSQADLHSDLKTLLEAGHIAWASSGRASWKLACHEFSDEGTHESQSSFT VEESITSFRLSNKINSKHLRVNQKILYESRFLNFSKFEIQSQAECQHVGRSVLTAKGLAL LQEGKAEITGNHDAHLNGKVVGTLRNSLFFSAQPYEMTASTNNEGNLRVSFPLKLTGKID FLNNYALFLSPSTQQASWQASGRFNQYKYHQNFSAGNNEKSIEAHIGINGEANLDFLNIP LKIPEMTLPYTKLTTPQIKEISLWKKTGLKDFLKTTKQSFDLSVRAQYKKNKDKHSIPVP LDAFYALIHRNINSFSRLFETVRNQALDFFIKSYNEAKTTFDKYKVEKSLNQPPKIYKIP GYTIPVANIEVSPFTVKMLTFEYMIPKEISTPSITVLGSSISVPSYTLVLPFLELPALPV PKELSELSLPEFKVLSTINKILIPALGNITYDFSFKSSIITLNTNVGLYNQSDIVAHFLT SSSSVMDTLQYKLEGTSSLTRKRGLKLATALSLSNRFVEGNHDSTVSFTKKNMDASVTTT ARVQIPILKMSFKQELHGNTKSKPTVSSAIELKYNFNSPKLLSAATGAVAHKLTLESLTS YFSIESSTKGGVEGSFGSWGYSGSLASEANTYLNSKGTRSSVTLQGASKADGLWDLKVKE NFAGEATLQRIYIIWEQNMKNHLELGGLILTSGEHTSKATLELSLWKISALVQVRAHQPN SLLKINFLGQEVSLNVNTENQKISWNSEVQVPSGSLQNNIQLSNDQEVARFDMAVSLEGY LRFLKDTVLPVYDKSLWDLLKLNVTTSLNRKQYLRAATALIYTKNPNGYLVSIPMQELDD KFIIPGLKRNNQNSIHVTPTFQVPFTDLQIPSYTLDLSEIKIYKKLSTLPLTFNVSTLPQ VKFPRVDVLIQYSKPEASSVPFFEITVPASQLTMSQFTLPKSISVGSTVLDLNTVASNIA DSELLTITVPEQTLEIPSMKFSVPAGILVPSFGTLTARFEVASPLYNTTWSAGLKNKGDH VETFLDSTCSSTIQFLEYDLNVVGTHKIEGGMLVYKTNASFAHRDFSAEYEEDGKYQGLG YWNGKVDLNITSPTLTDVCLHYQEDENHFSSSVASPAIGTVVIDVKNISNTVLGWNLYYR PQASPDKILNIFKIELRVLELDDEVQIKANWEEGAVSELLSSLKDSVPRATGALYDYVNK YHQEYTGLDLKDATLKLRRGLQDSADQVYQGAMRQIDEVDMELQRMARGTTETYQQWKDK AQSVYQELLAQEDRSGFQRLQKKVSDSLIGVTQGYSVTVKHATDLFIDLLNVTRFQLPGR ARNYTADELCTVVIQEIAKRLSQVHSNIHKGLHILFSYLLYLMEESELYKELNNKFSFTS MCNQLIDMALECMKTFLFFSQEIQKALSYLQSTMMTEMLSGLQRSLQDIFQEIESELKRF KEKKLTDFINQTLQNINTISDIYISFVFRFLKENLNYNFVEFNKLIQNKLQVASQELQQL LQYVQALHQEYFDPTTVGWTVKYYEFEEKVINLIKNLVDVLKDFHSKYIVGATDFASQLS SQIEPLIQKSLQEYLSILANAEGRGKEKITELSTSAQEVIKSWAVAVKEIISDYHQQFTY KLQEFSDQLSDYCEKFISESKRLIDLSIQNYHMFLNYIMELLKELQSATINDMSPYIKVA PGEFTITF NT seq 13707 nt NT seq  +upstreamnt  +downstreamnt atgggcgccccgaggcccgcggtgctgctgctgctgctgctgctgttcctggatgccgcc aacgcccaggccagagatgaagtgctggaaaatgtcagccccagctgtccaaaagatgca atgcgattcaagcacctcaggaaatatgtctataactatgaagctgagagttccagtggt gtccctgggactgctgattcaagaagcaccaccaagatcaactgcaaggtggagctggag gtcccccaactctgcaacttcatcctgaagacgagtgactgcaccctgaaagaggtggat ggcctcaaccctgagggcaaggaattgctgaagaagaccaagaactctgaggagtttgct gctgcgatgtccaagtacgacctcaagctggctgttcctgaaggcaagcaagttctactt tacccggagaaagaagagcctaaacacatcctcaacatcaagaggggcatcatctctgcc ctcctgcttcccccagaaacagaagaggctaagcaagtgttatttctggataccgtgtat ggaaactgctccacagactttactgttaaaacgaagacgggaaatgtggcaacagaaata tctattgaaagaaacctggagaagtgtgatcacttccagcccattagcacgggagttagc ccactcgctttgattagaggcatgacccgccccttgtcaacactgattggcagcagccag tcctgccggtacaccctggacccaaggaagaagcacgtgtcagaagctatctgcaatgag caacacctattcctgcccttctcctacaagaacaaatacgggatgatggcacaggtcaca cagactttgaaacttgaaaacacacctaagatcaacagccgcttctttgaggaaggcact gaggcagtgggccttgcctttgagagcaccaggtccacgtcacctccaaaccacgctgag gccattgtgaagacactccaggagctgcagaaactgcacgtctctgagcagaatgcccag agagccaacctcttccataaactagtgaccgagctgcgaggcctcagcagtgaggcggtc acctccctcttgccgaagctgatcgaggtgtccagtcccatcactttacaagccttgatt cagtgtggacagccccagtgctacactcacatcctccagtgcctgaaaaatgagagagcc aacccccttctgatagatgccgtgacctacctggtggccctgatcccagagccctcggcc gagaggctgcaggaggtctttaacactgcaagagtgcagcagagccggctcacgttttat gctctgagtcacatgatcaacaactatcataagacaaaccctacatggacacaggacctg ctggaaattgctgattacctgtcagaacagattggcaatgactgcactgggaacgaagat ctcacctacctgattctgagggtcataggaaatattggtaaaaccatggagcaactaacc cccaaactcacatcttcagtcctgaaatgtatcagaagtgaacagccatccctggtgatt cagaaggctgccatccaggccctgcggaaaatggagcttagtgacgaggtccgggaagtc cttcttcagactttcctcgatgacacctctccaggggataagcggctggctgcctacctc atgctgatggggagtccttcccagtcggatattagcaaaatcacccaacttctccctggg gaacagaatgagcaagtgaagaactttgtggcttcccacatcgccaacatcttaaactca gaagatttgtacgtccaggacttgaaaagcttagtggaagaagctctgaaaaaatctcag cttccaactatcatggatttcaagaaattttcccggagctatcagttttccaaattgatt tctctgccatcacttgacctggtctcagccaaaatcgaaggaaatcttatatttgatcca aacaattaccttcctaaagaaagcatgctgaaaacgaccctcaaagtctttggatttgct tcagctgacctctttgagattggtttggaaggaaaaggttttgaaccaacacttgaagct ctttttgggaaggaaggatttttcccagacagtgtcaacaaggctttgtactgggttaac ggtcgagttcctgatcgtgtctccaaggtcttggtggaccactttggctacaccaaagat gataaacatgagcaggacatggtcaatggagtcatgttcaatgttgagaagctggtcaaa gatctgaaatccaaagacttcccagaagccagagcctacctccgcatcttgggagaagag cttggctttgtcaaactccatgacctccaactcctggggaagttgctgctgaaaggtgtt cgtaccctgcaggggatccctcagatgattaaagagctcataaggaaaggttcaacaagt gacttgttccttcactacatcttcatggacaatgcctttgaactccccactggacttgga ttacaactgcaagtgtcctcctccggcatcatcactcctggaatcaaagctggagtgaaa ctggaagtagctgatatgcaggcagaactggtgacaaagccgtctgtgtctgtggagttt gtgacaaacatgggcatcgtcatcccagactttgccaggagcggggtgcagatgaacacc aacttcttccatgaaacaggcctggaggcacgagtagtcctaaaagccgggcagctgaag ttcatcattccttctcccaagaggccagtcaggctgttcagtggcagtaacacattgcat ttggtctctaccaccaaaacggaagtgatcccacctctcattgagaacaggcagtcctgg tcaacttgcaagcctttcttcattggcctgaactattgcatcacgggtgcatactccaat gccagctccacagactcttcctcctactacccgctgactggggacaccagatttgaactg gaattgaaacccacaggagaagtggaacagtattctgccaaggcattctatgaactccgg agagatggtgaagccttggtggacatgctgaagcttgtaactcagactgaaggtgtgaag cagaccgaggctactctgctgtttagatacaaccggcagagtaagaccttgtccagtgaa ctccacattccagattttgacattgaccttgggacagtcctcaaagttaattatgaacat tctaaggaaaagaagtcttacaagctcaccctggactttcagaacaagaaaatcactgag gtcaccctcactggccacataagctatgacaggaaggaagaaggcaaaatcaaaggtgtg atttccataccccgtttgcaagcagaagccagaagtgagattctcagcctctggtctccc tcaaaactgctccttcagatggactcctctgccacggcttacggctcaacaatatccaag aaggtggcatggcgttatgatggagataagattgaatttgaatggaacacaggcaccaat gtggatactaaaaaagcaacttccaatttccctgtggatctctctgcttttcctaaaagc ttgcatacgtatgccaatattctcctggatcgcagagttcctcagacagacctgactttt cggcacatgggttccaaattagttgctgcagcaagcacctggctccaggagacatcgagg agtcttccttatgcccagaatatacaagaccaactcagtggcctgcaagagttgtgcctc cagaaaatggaattgccaaacgtccacatcccagacaacctcttcttgaaaagtgacggt cggatcaaatacaccttgaacaagaacagtatggaaattgagatcccattgccttttggt ggcaaatcctccgaagatctaaagatgttcaagacgattcagactccagccctcaacttc cagcctctgggattccacctgccatcgcaagagttccaaatccctacttttaccatcccc aacttgtatccactgcggctgcccctcttgggtgtgctagacctctccacaagtatctac agcaacttgtacaactggtctgcctcctatactgggggcaacaccagcacagaccactgg agccttcaggctcagtaccacgtgaaggcagattctgtggtcaacctgctctcctaccac gtgcaaggatctggaaaaacagcatatgaccacaggaatacactcaccttctcaggtgat gggtctctacaccacaaatttctggattcaaatgtcaaattcagtcatgtagagaaaagg ggaaacagtccggcctcagaaggtctgctaacatttgacgcatccagtgcctggggccca cagatttctgcgtcagtccatttggactcaaagaagaaagagcatttgtacgtcaaggaa gtcaagattgacggacagctcagagcctctgcattctatgctaaaggcgtatatgacctg tcttatcagagagatcctgccacgggccagctcactggagaatccaacctgaggtttaac tcctcctatgtccagggcaccaatcagataacaggaaggtatgatgatggcactgtctcc attacctctacctcggatctgcaagatggcctcgtgaaaaatactgcttccctgaaatat gagaactatgagctgacagtgaaatctgacaccaacgggaagtatgaggactttgccacg tcaaacaaagtggatctgaccttctctaagcagcatgcattgctccgttctgagtatcag gctgattacaaggcactaaggttcttcaccctgctttctggatctctaaattctcacggc cttgagttaaatgccgatattttgggcactgacaagattaacagtggtgctcacaaggca acactcaggattgcccgggacggaatgtccaccagtgcaacgaccagcttgaagtataat cccctagtgctggagaatgaactcaacgcggcagtcagcctctctggggcatctctgaaa ttaacatcaaacggccgctttcgagaacaccatgcgaaattcagtctagatggaaaagct gcccccacagagctgtcgctgggaagtgcttatcaggccatgattctgggtgtcgacagc aaaaacatcttccacttcaaaatcaaccaggaaggactcaagctttcaaatgacataatg ggttcatatgatgaaatgaaacttgactacacaaacaatctgaacattgtagggttctca ctggacttctcttccaaacttgacaacatttatagctctgacaagttttataagcaaaat tttaatctacagttagagccctattccctggtaactactttaaacagtgacttgaaattc agtgctctggatatgaccaacaatggaaaattaaggctagaacctctgaagctgaatgtg ggtgggaccataaaaggagcctaccaaaatgatgaaataaaacacatctacactctttct tatgctgacttatctgcaagctataaagcagacactgtagctaaggtacagggaacagag tttagccatcggctcaacacgaacattgctgggcttgcttcaactgtggacatcagaaca aactacaactcagactccctgcatttcagcaatgcattccactctgcagtggccccattt acaatgaccatcgacacacatacaaatggcaatggggagctggttctctggggacaacac acggggcagctgtacagcaaattcctgttgaaagcagaacctctggcctttactttctcc catgactacagaggatccacaagtcaccgtctcatgtccaagagaagcatcaccactgct cttgatcacaaagtcagtgccctactcactctggccgagcagacaggcgactggaaactc aggacccagttgaaccaaaatgaatacagccaggacttcagtgcttacaacacaaaagac aaagctggtgttgagctcagtggacgagccctggctgacctcactgtgttggacttccct attgcagtgccacttgtcctcaacgagcccatcaatgtcattgacactttcgagatgagg gattctgttggccagccccaggaattcactcttgttgcttctgtaaaatatgataagaac caaaatgctcacaccatccatctcccattctttaaattcctgccaaaatattttgagaag actcgggtagtagttataggtgcactggagactgtacagaaagaattgaagcgcacccat attgataaacacatgaggaaatatgtagaagccttggacagactctcacagcaagttagt gattatctgagcacgttcaattgggagagacaagttttgagtgccaaggagaaactaact gctttcacagaaaatgacctgcaaattgtattagacaatgccacaatcaaccttaatgaa aaactgtctcagctgcaaacatatgtgatacaatttgatcagtattttgaagataattat gatttgcatgattttaagacaactattgctaagattattgatcaaatcattgaaaaattg aaaattcttgatgaacattatcatatccgtgtcaatttagtaaaaaaaatccgtgatctg tatttttttattgaaaattttgattttaacaaaactgaaagtagtactgcatcttggatt caaaatatggatactaagtatcaaatcagaatccagatacaagaaaaattgcaacagctc aaggtacagattcagactgtagacatccatcaccttgctgaaatgttcaaacagcaggtt gaagctgttgacgtcagagtgcttttagatcagttgagaactacaatcccatttcaaaga ataaaggaaattattgagcatgtcaaataccgtgttacaagtctttctgaaggttttaaa gtaactgaggaaatcaatgctttcagagtcatggtccatgagttcattaagatgtataaa atagatcaacacatccaggctttaatggataaatcagtgcagttggcccaacaatataag ctgcaggagactgttcagaagctaagcagtgtcctacagcaggtcaagatggcagaaatt gttgaaaaattgattgggcttaccgacaatgctctcaagcagcttgaagcattgtctttt aatcaattccttgaagaagtaaacagattccttgacatgttggtaaaaaaattaaggtca tttgattaccaccagtttgtagatgaaaccaataacaaaattcatgaggtgactcagcga atcaatgatgaaattcaggccctggaattcccacagaaagcaaaggcactcagactgctt gtagaggatgctaggattgtggtctcaacctatctggaaaacctaaaggccaccaaaatc accttagtcttggattggttacaggaggctctaagttcaacatctgtaacttacatgaaa gcaaagtttcaggagaccctggaagattttcgagaccgagtatatcaaatggatgtacag caggaactccagcggtacctattcctagtgggccaggtctacaacacactcgtcacctac atttctgactggtgggctcttgctgctaagaaccttactgactttgcagaacagtattct atccaagactgggctgaaaacctgaaaacgttagtagaacaagggttcactgttcctgaa atccagaccacctttgggaccatacctgccttcaaaatcggtctccgtgcccttcaggag gctacatatcagactcctgacttcatcgttcctctgacagatctgaggatcccatccttt cagatcaacttcaaaacactgaaggatgtgaaaatcccatccagcttttccacgccagaa tttaccatccttaataccctccacatcccttcctttacaattgacttcgtagaaataaaa ataaagatcgtcagaaccattgaccagatgctgaacagtgagctgcagtggccagtccca gaagtgtacctgggggatctgagcggggtggataccattcttgctggaatcactgtgcca gacttccatttaccggaaatcactattccagaatttgtcatcccgaatctcaaccttaca gattttcaagtttctgaccttcacatcccagaattccagcttccccatatctcacgcaca gttgaagtacctgcttttggcaagctgtacagcattctgaaaatccagtctccttttttc acattagatgcaaatgctgacattcagaatgcaacagctttggcaaaccaggcggagatg gaggcttccatcaccgccaaaggagcatccagattagaagtgctcaattttgattttcaa gcaaaagcacaactttcagaccctacacttaatccactggttctgaaggaatctgtgagg ttctccagcaagtacctgaagacagagcatgagagtgaggtgctctgggttggaaatgct attgagggaaagtcaaacacagtggcaggtatacacacagaaaaaaatacactggagctc agtagcagtgtgctcgtcaacataagtaatcaacttaccctggacagtaacacaaagtac ttccacaaattgaacatcccccagctggacttctccagccaggctgacctgcacagtgac ctcaagaccctgttggaagctggacacatagcatgggcttcttctggaagagcatcctgg aaattggcctgccacgaattctcagatgagggaacacatgaatcccaaagcagctttact gtggaagagtccatcacttccttcagattgtctaataagatcaacagcaaacacctaaga gtgaaccaaaaaatactatatgagtctcgattcctcaacttctctaaatttgaaatccag tcacaagctgaatgtcagcatgtgggtcgcagtgttctaactgctaaaggcctggcactg cttcaagaggggaaggcggagataactggcaaccatgatgctcatttaaatgggaaagtt gttggaactttgagaaattctcttttcttctcagcacagccatatgagatgactgcatcc acaaacaatgaagggaacttgagagttagctttccattaaaactgacagggaagatagac tttctgaataattatgcactgtttctgagtcctagtacccagcaagccagttggcaagca agtggcaggttcaatcaatataagtaccatcaaaatttctctgctggcaacaatgagaaa agcatcgaagcccacataggaataaatggagaagccaacctggatttcttaaacattcct ttaaaaatccctgaaatgactctaccttacacaaagctcacaactccccagataaaagaa atctccttatggaaaaagacaggcttgaaggatttcttgaaaacaacaaagcaatcattt gatttaagtgtaagggctcagtataagaaaaacaaagacaagcactccatcccagttcct ctggatgccttctacgctcttatccatcgtaacatcaattccttctccaggcttttcgag acagtcagaaaccaggcactagatttttttatcaaatcctataatgaagcaaaaactaca tttgataagtacaaagttgaaaaatcccttaaccagccacccaagatctataaaattcct ggatacactattccagttgccaacattgaagtgtctcccttcacagtgaagatgttaaca tttgagtatatgatccccaaagagatcagcacccccagcatcactgtcctgggttctagc atctccgtaccctcatacacgttagtcctgcccttcttagagctgccggcccttcctgtc cctaaggaactttctgagctttctcttccagagttcaaggtattgagtaccataaacaaa attttaattccagccctgggcaatattacctatgatttttcctttaaatcaagcatcatc acactgaataccaatgttggtctgtataaccagtcagatattgtcgctcattttcttact tcatcgtcttctgtcatggatacactgcagtacaaattagagggcacctcaagtttgacg aggaaaagaggactaaagttagccaccgctttgtccctgagtaacagatttgtggagggc aatcatgacagtaccgttagtttcaccaagaaaaatatggacgcatcagtgacgacaacg gcaagggtccaaattccaattttgaaaatgagtttcaagcaagagcttcatgggaatacc aagtcaaaacctactgtctcttcagccattgaattaaagtataatttcaattcccccaaa ctgctctctgctgctacgggagcagttgcccacaagctcaccttagaaagcctcacctct tacttttccattgagtcatctaccaaaggaggtgttgagggttcttttggttcatgggga tattcagggtctcttgccagtgaagccaacacttacttgaattccaagggcaccagatct tctgtgacactgcaaggagcctccaaagcagatggtctctgggacctcaaagtaaaagaa aattttgctggagaagccacactccaacgcatatatatcatctgggaacaaaatatgaaa aaccatttagagctagggggcctcattttaacatctggagagcatacaagcaaagccacc ctggagctctccctgtggaaaatatcagccctcgttcaggtccgtgcacatcagcccaat tccctccttaaaatcaatttccttggccaggaagtctccttgaatgttaacactgagaac cagaaaatcagctggaacagtgaggtccaggttccttctgggtctctccagaacaatata cagctctctaatgaccaagaagtggctcgctttgacatggcagtctccttagaagggtac ctacggttcctcaaagatactgtcctaccagtttatgacaaaagcttatgggacctccta aagctgaatgtcaccaccagccttaataggaaacagtatctccgtgctgcaactgccctc atatataccaaaaatcccaatggttatcttgtttctatccccatgcaagaattggatgat aaattcattattcctggactgaaacgaaataatcaaaattccattcatgtcacacctaca ttccaagtcccctttacagatcttcagattccatcctacacacttgacctcagtgaaata aaaatctacaagaagctaagtactcttccattgaccttcaacgtatcaactctaccccaa gtaaaattccccagagttgatgtgttaatacaatactctaaaccagaagcctcctctgtt cccttttttgagataactgtgcctgcatctcagttgactatgtcccagttcacccttccc aaaagtatttcagttggcagcactgttctggatctaaacacagtggccagtaacatcgca gactctgagctgctgaccatcaccgtgcctgagcagactcttgagattccttccatgaag ttctctgtacctgctggaattctcgttccttcctttggaacactgaccgcgcgttttgag gtggcctcgcccttgtataacaccacttggagtgctggtttgaaaaacaaaggagatcat gttgaaacattccttgattccacatgcagctcgaccattcagttcctggaatatgaccta aatgttgtaggaacacacaaaatcgaaggtggcatgttagtgtataagactaacgcatcc tttgcacaccgtgacttcagtgcagaatatgaagaagatggcaaatatcaaggacttggg tactggaatggaaaggttgaccttaacatcaccagcccaacattaactgatgtctgtctg cactaccaagaagatgagaaccacttctcctcatcagtagcctccccagccataggcact gtggtcatcgacgtgaaaaacattagcaataccgtattgggatggaacctctactaccgc cctcaggcctctccagataaaatactcaacatattcaaaattgagttgagggtcctggaa ttggatgatgaagttcagatcaaagctaactgggaagaaggagctgtgtccgaattgcta agctcgctcaaagacagtgtgcccagggccacgggagccctttatgactatgtcaacaag taccaccaggagtacacgggacttgatctgaaagatgctactttaaaactgaggagaggc ctacaggacagcgctgatcaggtgtatcaaggggccatgaggcagattgatgaagtggac atggagctccaaaggatggccagaggcaccactgaaacctaccagcagtggaaggacaag gcccagagtgtgtaccaggaactgttggctcaggaggaccgcagtggtttccagagactc cagaagaaggtgtcagacagcttaataggagttactcagggatacagcgtgacagtcaag catgcgactgacttgttcattgatctcctgaatgtaaccagattccagctcccaggaaga gccaggaactacactgcagatgagctctgcactgtggtcatacaagaaatagcgaagcga ctatcccaggtacattcaaatatccataaaggattacatatactgttttcctatttactg tacctgatggaggagtctgagttatacaaggaactaaacaataaattttcttttacatca atgtgcaatcaactaatagatatggccttggagtgtatgaaaacatttctatttttctca caagagatccaaaaggcactcagttacctccagtctaccatgatgacagagatgctaagt ggtcttcaaaggtctctacaagacattttccaagagatagaaagtgaacttaaacgcttc aaggagaagaaattgactgatttcattaatcaaaccctacagaatatcaatacaatctcc gacatatacatttcatttgtttttagattcctgaaagaaaacctaaactataactttgtt gagtttaataaactaatccaaaacaaacttcaggtagcttctcaagaattacagcagctc cttcagtatgtgcaggctcttcaccaagaatattttgatccaactacggttggctggaca gtgaaatattatgaatttgaagagaaggtcatcaacctgatcaagaacctagtagatgtc cttaaggacttccattccaaatacattgtcggtgctactgattttgcttcccaactctca agtcagattgaaccattgatacagaaaagtttgcaggagtatcttagcatccttgccaat gcagagggaagggggaaagagaagattacagagctttctaccagtgctcaggaagtaatt aaaagctgggctgttgcagtgaaggaaatcatttctgattaccaccagcagttcacatat aaactacaggagttttcagaccagctctctgattactgtgaaaaatttatctctgagtct aaaagattgattgacctgtccattcaaaactaccacatgtttctgaactatatcatggag ttgctgaaagagctacaatcagccacaatcaatgacatgagcccctacataaaggttgct ccaggagagtttactatcaccttctga

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