Bison bison bison (American bison): 104989034 Help Entry 104989034         CDS       T08726                                  Symbol ADCY3 Name (RefSeq) adenylate cyclase type 3   KO K08043   adenylate cyclase 3 [EC:4.6.1.1] Organism bbis  Bison bison bison (American bison) Pathway bbis00230   Purine metabolism bbis01100   Metabolic pathways bbis01522   Endocrine resistance bbis04015   Rap1 signaling pathway bbis04020   Calcium signaling pathway bbis04022   cGMP-PKG signaling pathway bbis04024   cAMP signaling pathway bbis04062   Chemokine signaling pathway bbis04072   Phospholipase D signaling pathway bbis04081   Hormone signaling bbis04082   Neuroactive ligand signaling bbis04114   Oocyte meiosis bbis04211   Longevity regulating pathway bbis04213   Longevity regulating pathway - multiple species bbis04261   Adrenergic signaling in cardiomyocytes bbis04270   Vascular smooth muscle contraction bbis04371   Apelin signaling pathway bbis04540   Gap junction bbis04611   Platelet activation bbis04713   Circadian entrainment bbis04714   Thermogenesis bbis04723   Retrograde endocannabinoid signaling bbis04724   Glutamatergic synapse bbis04725   Cholinergic synapse bbis04727   GABAergic synapse bbis04740   Olfactory transduction bbis04750   Inflammatory mediator regulation of TRP channels bbis04911   Insulin secretion bbis04912   GnRH signaling pathway bbis04913   Ovarian steroidogenesis bbis04914   Progesterone-mediated oocyte maturation bbis04915   Estrogen signaling pathway bbis04916   Melanogenesis bbis04918   Thyroid hormone synthesis bbis04921   Oxytocin signaling pathway bbis04923   Regulation of lipolysis in adipocytes bbis04925   Aldosterone synthesis and secretion bbis04926   Relaxin signaling pathway bbis04927   Cortisol synthesis and secretion bbis04928   Parathyroid hormone synthesis, secretion and action bbis04934   Cushing syndrome bbis04935   Growth hormone synthesis, secretion and action bbis04962   Vasopressin-regulated water reabsorption bbis04970   Salivary secretion bbis04971   Gastric acid secretion bbis04972   Pancreatic secretion bbis04976   Bile secretion bbis05032   Morphine addiction bbis05163   Human cytomegalovirus infection bbis05166   Human T-cell leukemia virus 1 infection bbis05200   Pathways in cancer bbis05207   Chemical carcinogenesis - receptor activation bbis05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:bbis00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     104989034 (ADCY3)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     104989034 (ADCY3)    04371 Apelin signaling pathway     104989034 (ADCY3)    04020 Calcium signaling pathway     104989034 (ADCY3)    04072 Phospholipase D signaling pathway     104989034 (ADCY3)    04024 cAMP signaling pathway     104989034 (ADCY3)    04022 cGMP-PKG signaling pathway     104989034 (ADCY3)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     104989034 (ADCY3)    04081 Hormone signaling     104989034 (ADCY3)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     104989034 (ADCY3)   09144 Cellular community - eukaryotes    04540 Gap junction     104989034 (ADCY3)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     104989034 (ADCY3)    04062 Chemokine signaling pathway     104989034 (ADCY3)   09152 Endocrine system    04911 Insulin secretion     104989034 (ADCY3)    04923 Regulation of lipolysis in adipocytes     104989034 (ADCY3)    04912 GnRH signaling pathway     104989034 (ADCY3)    04913 Ovarian steroidogenesis     104989034 (ADCY3)    04915 Estrogen signaling pathway     104989034 (ADCY3)    04914 Progesterone-mediated oocyte maturation     104989034 (ADCY3)    04921 Oxytocin signaling pathway     104989034 (ADCY3)    04926 Relaxin signaling pathway     104989034 (ADCY3)    04935 Growth hormone synthesis, secretion and action     104989034 (ADCY3)    04918 Thyroid hormone synthesis     104989034 (ADCY3)    04928 Parathyroid hormone synthesis, secretion and action     104989034 (ADCY3)    04916 Melanogenesis     104989034 (ADCY3)    04925 Aldosterone synthesis and secretion     104989034 (ADCY3)    04927 Cortisol synthesis and secretion     104989034 (ADCY3)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     104989034 (ADCY3)    04270 Vascular smooth muscle contraction     104989034 (ADCY3)   09154 Digestive system    04970 Salivary secretion     104989034 (ADCY3)    04971 Gastric acid secretion     104989034 (ADCY3)    04972 Pancreatic secretion     104989034 (ADCY3)    04976 Bile secretion     104989034 (ADCY3)   09155 Excretory system    04962 Vasopressin-regulated water reabsorption     104989034 (ADCY3)   09156 Nervous system    04724 Glutamatergic synapse     104989034 (ADCY3)    04727 GABAergic synapse     104989034 (ADCY3)    04725 Cholinergic synapse     104989034 (ADCY3)    04723 Retrograde endocannabinoid signaling     104989034 (ADCY3)   09157 Sensory system    04740 Olfactory transduction     104989034 (ADCY3)    04750 Inflammatory mediator regulation of TRP channels     104989034 (ADCY3)   09149 Aging    04211 Longevity regulating pathway     104989034 (ADCY3)    04213 Longevity regulating pathway - multiple species     104989034 (ADCY3)   09159 Environmental adaptation    04713 Circadian entrainment     104989034 (ADCY3)    04714 Thermogenesis     104989034 (ADCY3)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     104989034 (ADCY3)    05207 Chemical carcinogenesis - receptor activation     104989034 (ADCY3)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     104989034 (ADCY3)    05163 Human cytomegalovirus infection     104989034 (ADCY3)   09165 Substance dependence    05032 Morphine addiction     104989034 (ADCY3)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     104989034 (ADCY3)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     104989034 (ADCY3)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     104989034 (ADCY3) Enzymes [BR:bbis01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      104989034 (ADCY3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc AC_N HNOBA Peptidase_S49_N Motif Other DBs NCBI-GeneID:  104989034 NCBI-ProteinID:  XP_010838865 Ensembl:  ENSBBBG00000018516 UniProt:  A0A6P3HJZ3 LinkDB All DBs Position Unknown AA seq 1145 aa AA seqDB search MPRTQGFSEPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSGSCLCLPRFMRLTFVPE SLENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSGDKLAPLAVAGVGLVLDII LFVLCKKGLLPNRVTRRVVPYLLWLLISAQVFSYLGLNFSRAHAASDTVGWQAFFVFSFF ITLPLSLSPIVIISVVSCVVHTLVLGVTVAQRGQDSVQSVQLLSHILANVFLYLCAIVVG IMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKDMKKDES QKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQ LRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTV LGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGEGGSRCD YLEEKGIETYLIITSKPEVKKTAAQNGLNGSALLNGAPPSSKPSSPALIETKESNGSIHT SGSISEEPEEQDAQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESA QVVKQRNTFLLSMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLLCTAVVEILIDPWLMTN YVTFVVGEALLLILTICSLAAIFPRAFPKKLVAFSTWIDRTRWARNTWAMLAIFILVMAN VVDMLSCLQYYTGPTNGTTEMQVEDGCVENPKYYNYVAVLSLIATIMLVQVSHMVKLTLM LLIAGAVAVINIYAWCPIFDDYDRKRFQQHDFPMVALEKMQVFSSSGLNGTDRLPLVPSK YSMTVMIFVMMLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEH VARHFLGSKKRDEELYSQSYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDF DSLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFTSSNKDEKSDKERWQHLADLADF ALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGV MGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFLKGRDKLATFPNGASITLPHQ VVDNS NT seq 3438 nt NT seq  +upstreamnt  +downstreamnt atgccgaggacccagggcttctccgagcccgagtactccgcggagtactcggccgagtac tctgtcagcctgccttcggaccctgaccgcggggtgggccggacccatgaaatctctgtc cggaactcggggtcgtgcctctgcttgcctcgcttcatgcggctgaccttcgtaccagag tccttggagaacctgtaccagacctacttcaagaggcagcgccacgagaccctgctggtg ctggtggtcttcgcggccctcttcgactgctatgtggtggtcatgtgcgctgtggtcttc tctggcgacaagctggcccccctggccgtggctggggtcgggctggtgttggacatcatc cttttcgtgctctgcaaaaaggggctgctccccaaccgggtcactcggagagtggtgccc tacctgctgtggctgctgatatcagcccaggtcttctcctacctgggcctgaacttctcc cgtgcccacgcggccagcgacacggtgggctggcaggccttcttcgtcttctccttcttc atcacgctgccgctcagcctcagccccattgtcatcatctccgtggtctcctgcgtcgtg cacacactcgtcttgggggtcactgtggcccagcgtggccaggattcagttcagtcagtt cagttgctcagtcatattctggccaacgtcttcctctacctgtgcgccatcgtcgtgggc atcatgtcctactacatggcagaccgcaagcaccgcaaggccttcctggaggcccgccag tctctggaggtgaagatgaacctggaggagcagagtcagcagcaggagaaccttatgctc tccatcctgcccaagcacgtggccgacgagatgctgaaggacatgaagaaggatgagagc cagaaggaccagcagcagttcaacaccatgtacatgtaccgccatgagaacgtcagcatc ctctttgctgatatcgtgggcttcacccagctgtcctcagcctgcagcgcccaggagctt gtgaagctgctcaatgagctctttgcccgcttcgacaagctggcagctaaataccaccag ctgcggattaagatcctgggcgactgttactactgcatctgtgggctgcctgactaccgg gaggaccacgccgtctgctccatcctcatggggctcgccatggtggaggccatctcgtat gtgcgggagaagacgaagaccggggtggacatgcgcgtgggggtgcacacgggcaccgtg ctggggggcgtcctcggccagaaacgctggcagtacgacgtgtggtccaccgacgtcacc gtggccaacaagatggaggctggcggcatccctgggcgcgtgcacatctcccagagcacc atggactgcctgaaaggagagttcgacgtggagccgggcgaggggggcagtcgctgtgat tacctggaagagaagggcatcgagacctacctcatcatcacgtccaagccagaggtgaag aagacagctgcccaaaatggcctcaacggctcggccctgctgaatggagcgccgccttcc tcaaagcccagctcccctgccctcattgagaccaaggagtccaacgggagcattcacacc agcggctctatatctgaggagcccgaggagcaagatgcccaggccgacaacccctcgttc cccaaccctcgccggaggctgcgccttcaggacctggctgatcgcgtggtggacgcctcc gaggacgagcatgagctcaaccagctactcaacgaggcgctgctagagcgggagtctgcc caggtagtgaagcagagaaacaccttcctcctgtccatgcggttcatggaccccgagatg gaaacccgctactcggtggagaaggagaagcagagcggggctgccttcagctgctcctgc gttgtcctgctctgcacggccgtagtggagatcctcattgacccctggctcatgacgaac tatgtgacctttgtggttggggaggctctgctcctgatcctgacaatctgctcgctggct gccatctttccgcgggcctttcctaagaagctcgtggccttctctacttggattgaccgg acgcgctgggccaggaacacctgggccatgctggccatcttcattcttgtcatggcaaac gtggtggacatgctcagctgtctccagtactacacaggacccaccaacggcaccacagag atgcaggtggaggatggctgcgtggagaaccccaagtattacaactacgtggccgtgctg tccctcatcgccaccatcatgctggtgcaggtcagccacatggtcaagctcacactcatg ctgctcatcgcgggggccgtggctgtcatcaacatctacgcctggtgccccatctttgac gactacgaccgcaaacgcttccagcaacacgactttccaatggtggccttagagaagatg caggtgttttccagctcggggctcaatggcactgacaggctgcccctggtgccgtctaag tactcgatgacagtgatgatctttgtcatgatgctgagcttttactacttctcccgccac gtggaaaagctggcacggacactgttcttgtggaagattgaggtccacgaccagaaggaa cgtgtctatgagatgcgacgctggaacgaagccttggtcaccaacatgctgcctgaacac gtggcacgccatttcctggggtccaagaagagagatgaggagctgtacagccagtcttat gatgagattggagttatgtttgcctccctgcccaattttgctgacttctacacagaggag agcatcaataacggtggcattgagtgtctacgcttcctcaatgagatcatctcagatttt gactctcttctggacaatcccaagttccgggtcatcaccaagatcaagaccattggtagc acctacatggcagcttcaggagtcaccccagatgtcaacaccaatggctttaccagctcc aacaaggacgagaagtcagacaaggagcgctggcagcacctggcagatctggccgatttt gcgctggccatgaaggacacgctcaccaacatcaacaaccagtccttcaacaacttcatg ctgcgcattggaatgaacaaaggaggggtcctggctggggtcattggagcccggaaacca cactatgacatctggggcaacacagtcaatgtagccagcaggatggagtccacaggggtc atgggcaacatccaggtggtggaagaaacccaagtcatccttcgagaatacggcttccgc ttcgtgaggagagggcccatctttgtgaaagggaagggggaactgctaacctttttcttg aagggccgagacaagctggccacattccctaacggcgcctcaatcacactgcctcaccag gtggtagacaactcctga

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