Bison bison bison (American bison): 104989273 Help Entry 104989273         CDS       T08726                                  Symbol SYNE1 Name (RefSeq) nesprin-1   KO K19326   nesprin-1 Organism bbis  Bison bison bison (American bison) Pathway bbis04820   Cytoskeleton in muscle cells Brite KEGG Orthology (KO) [BR:bbis00001]  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     104989273 (SYNE1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:bbis03036]     104989273 (SYNE1) Chromosome and associated proteins [BR:bbis03036]  Eukaryotic type   Centrosome formation proteins    LINC complex     104989273 (SYNE1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Spectrin Spectrin_SYNE1 SYNE1 CH KASH PBP_N Motif Other DBs NCBI-GeneID:  104989273 NCBI-ProteinID:  XP_010839210 Ensembl:  ENSBBBG00000012707 UniProt:  A0A6P3HL21 LinkDB All DBs Position Unknown AA seq 8853 aa AA seqDB search MATSRAASRAPRDIANVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDG VKLLALLEVLSGQKLPCEQGRRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPS IVLGLMWTIILYFQIEELTSNLPQLQALSSSTSSVDSMVSSETASPPSKRKVATKIQGNA KKALLNWVQYIVTKQSGIEVKDFGRSWRSGVAFHSVIHAIRPELVDLEKVKGRPNRENLE EAFTIAETELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKQYPDIHSTGSDGQENDEILP SFPSFTNSIQILKREDRLILKEMKVWIEQFERDLTRAQMTDSSLQDKYQSFKHFRVQYEM KRKQIEHLLQPLHRDGKLSLDQALVKQAWDRVSSRLFDWHIQLDKSLPAPLGTIGAWLYR AEVALREEITIQQVHEETANTIQRKREQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPD QLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGGRDSVELLL QNYISFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVE VRSVRSMLEEVIANWDRYGNTVASLQAWLEDAEKMLNQSEHAKKDFFRNLPHWIQQHTAM NDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYARADELDRMKKEYNDCVTIL SDFATEAHRKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKMITKTAHLITKEISQE EANEMFATMSGLKEQLTKVKDCYSPLLSESQQLLVPLEELEKQMTAFYDSLGKIDEIMTV LEHEAQSSPLFKQKHQDLLACQESCKKAMTQIEKGSQSVQKFVTLSNVLKHFDQTKLQRK IADTHVAFQNMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRVAQEGLEEKGDPEDLL KRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQRGLQEAVRKLHKQWKDLQAEAPYHLL HLKIEVEKNRFLASVEECRAELDRETKLVPQEGSEKIIKEHRIFFSDKGPHHLCEKRLQL IEELCLKLPVRDAVRNTPETCHVTLKELRAAIDRTYVKLVGDPDKWKDYTSRISEFSSWI SAKETQLKGIKNETIDTANQGEVKRALEEIRSGITKKGETLSWLKSRLKILIEVSSEDEA QKQGDELAKLSSSFKALGTLLSEVEKMLSNFGDCVQYKEIVKSSLEELITGSKEVQEEAE KILDTENLFEAQQLLLHHQQKTKRINAKKKDVQQQITQAQKGEGGLPGRVQEELQKLEST LDSVEHSREKQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELE QTKEFSKRTEGIAVQAENLVKEASEIPLGPKNKQLLQQQAKSIKEQVKKLEDTLEEDIKT MEMVKNKWDHFGTNFETLSVWITEKEKELNALETSSSAMDTQINQIKVMIKEIESKISSI TGLEEEAQSFAQFVTTGESARIKAKLTQIRRYWEELREHAQSLQGIILGHLSQQQKFEEN LKQIQQSVSEFEDKLADPVKICSSATETYKVLQEHMDLCQALESLTSTVAALSASARKVS NRDASIQEAATVQRSYEGLLGRAKERQTELEKLLARWQRLEKELSTFLTWLERCEAIASS PEADISADRVKVESELQSIQVLQNEVVSQASIYSNLLQLKESLFSVASKDDVKMMKLQLD QLDERWRDLPQIISKRISFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQ AALTRHKDHAAEVESKKGELQSLQGHLAKLGALGRAEDLHLLQGKAEDCLQLFEEASQVV ERRQHALSQLAEFLQSHASLSESLHQLRQTVEATHSMNKKQSDLLERDLNDAIRNVKTLE SAAISLDGLLTKAQYHLKSGGSEQRTSCRATSDHLSVELERIQNLLGTKQSEADALAVLK KAFRDQKEELLKSIEDIEERTDKERLKDLTRQALQQRLRVFNQLEDELNSHEHELCWLKD KAKQIAQKDVAFAPEVDKEINRLEVTWNDTKKLIHENQGQCCGLIDLMREYQNLKSAITK VLENASNVIATRTTVKDQEDLKWALSKHETAKNEMCNKQKDLDNFTSKGKQLLSELKKIH SGDFIVVKTDMESTVDKWLDISEKIEENMDRLRVSLSIWDDILTSKDEIDGWSNHSVPQL TESISNLNDSLRAEEFLKEFESEVKKKALRLEELHSKVNDLKELTKNPETPPDLQFIEAD LRQKLEHAKEITEEAKGTLKEFTAQSAQVEKFINDTATWLTKLEESLMNCAQTETCEGLK KVKDIQKELQSQQSNISMTQENLNSLCRKYHSVELGSLGSAMTGLIKRHEAVSQSCSKTQ ASLQDSLEKHFNESMQLFQEWFSGIKAAAKESSDRTGDSKVLEAKLRDLQNILDSVSDGQ SKLDAVTREGQTLYAHLSKQIVSSIQEQVTKANEEFQAFLKQCLKDRQALQDCALELGSF EDQHRKLNLWIHEMEERLSTENLGESKQHIPEKKNEVHKIEMFLGELLAARESLDKLSQR GQLLSEEGHGAGKESRLCSQLLTSYQNLLRMTKEKLRSCQVALQEHEALEEALQSMWSWV KDMQDRLASAESTVGSKDALERRLLQVQEILLMKGEGEVKLNMAIGKGEQALRSSNKEGQ KVIQTQLQTLKDVWANIVDSSVHAQSTLESVISQWNDYLEWKNQLEQWMESVDQKVEHPL QPQPGLKEKFSLLDHFQSVVSEAEDHAGALQRLTAKARELYQKTEDEALTDMAQEELKTQ FNDILTVSKEKMRKVEEIVKDHLMYLDAVQEFTDWLHSAKEELHRWSDMSGDSPATQKKL SKIKELMDSREIGASRLSRVESLAPAVKRNTTASGCELLDTEMQALRADWKQWEDSVFQT QTSLENLVSQMALSEQEFSGQVAQLEQALEQFSALLTSWTQQLALLEGKNTDKELVECWQ KGREILDALQKAEPQTENLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQN KEQILQQRFLRAFKDFQQWLVNAKITTAKCFDIPQNINEVSTSLQKIQEFFSESENGQHK LNTMLSKGELLCTLLTKEKASSIQAKIATAKEDWKNFHSNLHQKESALENLKIQMKDFEV SAEPVQDWLSKTEKMVHESTNRLYDLPAKRREQQKLQSVLEEINCYEPQLRRLKEKAQQL WEGQAASRSFMHRVSQLSSQYLALSNVTKEKVSRLDRIVAEHNQFSLGIKDLQDWMTDTV HMLDSYCHPTSDKSVLDSRMLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPAIQ QQLASVKDMWASLLSAAIRCKSQLEGALSKWTSYQDDVRQFCSWMDGVEASLNASERQHA ELREKTAALGKAKLLNEEVLSHSSLLETIEVKGAGMTEHYVTQLEFQDLQERYGAIRERT KEAVTKSEKLVRLHQEYQRDLKAFEAWLEKEQDKLDRYSVLEGDAHTHETALRDLQELQV RCAEGQALLNSALHTREEVIPSGIPQTEDRALESLRQDWQAYQQRLSETRTQFNNVVNKL RLVEQKFQQVDEWLKTMEEKVSLRTARQSSRVAKEMQLHQMKKWHEEITAYRDEVEEVGA RAQEILDESHVSSRMGCQATQLTSKYQALLLQVLEQIKFLEEEIQSLEESELSLSSYSDW YSSTHKNFKNVAAKIDKVDKAMMGKKMKTLEGLLKDMEKGQSLLKSAREKGERALKYLED SEAETLRKEIHDHVERLKELTSTVRKEYMTLEKGLHLTKEFSDKYKALTQWIAEYRDILH GPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQ SDYQDLCSVAKEHVCSLEAKVRDHEDYNSELQEVEKWLLQMSGRLVAPELMETSSLETIT QQLARHKAMMEEIAGFEDRLNDLKTKGDSLISQCADHLQAKLKQNVHAHLQGTKDSYSAI CSTAQRVYQSLEHELQKHVCRQDTLQQCQAWLSAVQPDLKPGANPPLSRAEAVKQVKHFR ALQEQARTYLDLLCSMCDLSNSSVKTTAKDIQQTEQMIEQRLAQAQNLTQGWEEIKHMKA ELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQCKQASVNTITEKVDELT KKQESPEHKEISHLNDQWLDLCLQSNNLCLQREEDLQRTRDYHDRMNVVEGFLEKFTTEW DNLARSDAESTAVHLEALKKLALALQERKKAIEDLKERKQKMIEHLNLDDKELVKEQTSH LEQRWFQLEDLVKRKIQVSITNLEELSVVRSRFQELMEWAEEQQPNIAEALKQSPPPDMA QNLLMDHLAICSELEAKQMLLKSLTKDADRVMADLGLNERQIIQKALSDAQRHVSSLSDL VGQRRKYLNKALSEKTQFLMAVFQATSQIQQHEHKIMFREHICLLPDDVSKQVKTCKSAQ ASLKTYQNEVTGLWAQGRELMKGVTEQEKSEIQGKLQELQSVYDTVLQKCSHRLQELEKN LVSRKHFKEDFDKACHWLKQADIITFPEINLMNETAELHTQLAKYQHILEQSPEYENLLL SLQRTGQAILPTLNEVDHSYLDEKLHALPLQFNVIVDLAKDKFYKVQEAMLARKEYASLI ELTSQSLRDLEDQFSRMSQIPGHLSVEEAMSLQDGWRALGGEVAGLTEAVDELNQKKESF RSTGQPWQPDKMPQLITLYHRLKRQTEQRVSFLEDTTSAYQEHEKMCLQLEKQLEAVRME QSKVNEETLPAEEKLKVYHSLAGSLQNSGILLKRVTRHLEDLISHLDPAAYEKAKHQLQA WQEELKLLTSAIGATVTECESRMVQSRDLQTELSRSLEWLRSVEAALSGPLCLDPNLRDI QEEIRKVQIHQEEVQSSLRIMNALSNKEKEKFTRAKELISADLQRTLAELSELDGALQEA LRTRQTTLTQIYSQCQRFYQVFQAANDWLEDAHEMLQLTGNGLDVESVEESLKSHMEFFS AEDQFHSNLEELQGLVANLDPLIKPTGKEDLAQKMASLEEKSQTIMQDSHAQLELLQRCA AQWQDYQKAREEVIELMNEAEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVINSFHEKIV ALEGEASELERTGNDASKAAISRSTTAVWQRWTRLRAVAQDQEKLLEDAVDEWTSFNNKV KKASEVIDQLQDKLPGSSAEKASKAELVTLLEYHDTFIXELERQQSALGMLRQQALSMLQ DGVTPSPGGEPPTVQEITAMQDRCLNIQEKVKKNGKIVKQELKEREVVETHISSVKSWVQ ETKEYLGNPTIEIDAQLEELKILLTEAINHQQNVEKMAEEQKNKYLGLYTILPSELSLQL AEVALDLGTTHDQIQDKVKEVEQSKAMSQEFSQQIQKIARDLTTILTKLRAKTNNLVQAK TDQKVLGEELDGCHLKLMELDKAVQKFSEQNGQLGKPLAKKIGKLTELHQQTIRQAENQL SKLNQAASHLEEYNEILELILRWIEKTKILVHGKIAWNSASQLREQYISHQTMLEESEDI HNDLEAMSEKLQYLDSVYHTETMSQQVADLGRETEELRQVIKIRLQSLHDAAKDMKKFEA ELRNLQVALEQAQTTLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVHAVQVRQSALRIP EDVVASLPLCHAALHLQEEASRLQHTAIQQCNIMQEAVVQYEQYEQEMQHLQELIEGAHR EIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVT EVEGLAEGTEDLDGELLPATSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPAC RSPSPVANTDASVNQDIAYYQALSPERLQTDAAKVPPSTLPPQELYEPGLEPSATAKLDD LQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIEMKLSESLEQGRSPESQ MAEHQALMDEILMLQEEISELQSALADELASESPESEPAEQLALQSTLTVLAERMSTIKM KASGKRQLLEEKLNDQLEEQRQEQALNRYRCEADQLDHWLLSTKATLDIALGSPKEPMDM EAQLVDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAVKLRTLKGSLLEL QRALQDRQLHIQGTAQEKEESDADLAATQSPGVQEWLAQARSAWTHQRQSSLQQQKELEQ ELAEQKSLLQSVASLGEEILTQHSAAETSGGVGEKPDVLSQELGMEGEKSPAEDQMRMKW ESLHQEFSTKQKLLQNVLEQEQEQMLYSRPNRLLSGVPLYKGDGQAQDKSAVTSLLDGLN QVFEEVSSQGGGTKKQNIDLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCIFNQ ETLAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQM KERLQQILNFQNDLKVLVTSLADHKYIILQKLAKMFEQPVAEQIEAIQQAEDGLKELDAG IIELKRHADKLQIEQPSMQELSKLQDMYDELMMTIGSRRSGLNQNLALKSQYERALQDLA DLLETGREKTAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVPRE TQFHTDLMAQASAVLKGAHKRGVELEYILETWSQLEKEHWELSRQLEVVESSTPSVGLVE ESEDRLIDRIALYQVSVQMTVWCKKLPHRFLKLSLGFNRSTQTFNPIFSFSKCFPLPKLY QVIDDGKRLLISVSCSDLESQLNQLGEHWLSDTNKVSKELHRLETILKHWTRYQSESADL IHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNGFLEFSKEVDAKSTLKSSVLSTGNQLL RLKKVDTAALRSELSHIDGQWNDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMTWISLME SVIQKDEENIKNSIGYKTIHEYLQKYKGFQIDINCKQLTVDFVNQSVLQISSQDVESKRS DKTDFAERLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQ QHRIGDQASVQNAMKDCQDLEDLIKAKEKEVEKIEQNGLALVQNKKEEVSGIVRSTLQEL NQTWANLDHMVGQLKILLKSVLDQWSHHKVAFDEINSCLMESRYSLSRFCLLTGSLEAVQ VQVDNLQNLQDDLEKQEKSLQKFGSVTNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEI AEQLRASKALLQLWQRYKDYFKQCAATVQQQEGRTNEFLKAATDKDIGDDEVATWIQDCN DLLKGLGPIQDSLVVLHELGGQLKQQVDASAASAIQSDWLSLRQQLHALEQALCKQQTVL QAGVLDYETFTKSLEALETWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMV PDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCET WMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIFDGQHLLEQGQV DDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIHQWQRYREMAEKLRKWLVEVSCLPV SGLGSVQIPLQQARALFDQVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEATLQAEL AEIQEKWKSASVCLEEQKKKLAGLLQDWEKCENGIADSLEKLRTFKKRLSQPLPDHHEEL HAEQMCCKELENTVGSWTDDLAQLTLLKKALCAYISADDISILNERMELLQRQWEELCHQ LSLRRQQVSERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLRKDYQEEIA IAQENKIQLQQMGERLARASHESKASEIEYKLGKINDRWQHLLDLMAARVKKLKETLVAV QQLDKNMSSLRTWLAHIESELAKPIVYDSCDSEEIQKKLNEQQELQRDIEKHSTGVASVL NLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDD FSHFEDWLKISERTAAFPSSSGVLYTVAKEELKKFEAFQRQVHESLTQLELINKQYRRLA RENRTDAAGSLKQTVHKGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEM DLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAVIEE ELDELRRYCQEVFGRVERYHKKLICLPLPDDEHDLSDRELELDEAGTLSDLHWRDTSTDG VLSPQPSSNPSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAVSRTLPSED EEGPEDKDFYLRGAVGLSDVVIPENPEAYVKLTESAIRNSSGDPGALESQIQQLGKALDD SRFQMQQTENIIHSKTPTGPELDSGYRGYMKLLGECSGSIDSVKRLEHKLTEEEDHFPGF VNLNSTETQTAGVIDRWELIQAEALSKELRMKQKPQRRQQLDSDLNSVLTWLRETEGDLE QLQRLQLSTDIQSIALQIQKLKELQKAVDQRKAIILSIHLCSSEFTQPGREESQDLQDRL SQMNGRWERVCSLLEEWRGLLQDALMQCQDFHEMSHGLLLMLENIDRRKNEIVPIDSNLD AEILQDHHKQLKQIRHELLESQLKVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKL LLKEVSRHIKELEKLLDMSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCS LSQPGPSVNSPHSRSIRGGSDSSLSEPRPARSGRAFLFRVLRAALPLQLLLLLLIGLACL VPMSEEDYSCALSNNFARSFHPMLRYTNGPPPL NT seq 26562 nt NT seq  +upstreamnt  +downstreamnt atggccacctccagggcagcctcgcgggcccctcgggacatcgccaacgtgatgcagagg ctgcaagatgagcaagagatagtacaaaaacgtactttcacaaaatggatcaactctcat ctggccaagcggaaacccccaatggtggtagatgatctttttgaagacatgaaagatggt gtgaagctacttgctctgctggaagtcctgtctgggcagaaactgccatgtgaacaaggg cgccggatgaagagaattcatgccgtggcaaacattggcacagcactgaagttccttgaa ggaaggaagattaaattagtcaacattaactccactgatatagctgatggtcgaccctcc attgttctcggattgatgtggaccattatcctgtatttccagatcgaggagttgaccagc aacctgcctcagctgcaggctctgtccagcagcacgtcctccgtggacagcatggtcagc tctgagaccgccagccccccgagcaaacggaaggtggccaccaagatccaaggaaacgct aagaaggcgctattgaactgggtccagtacatagtcaccaagcagagtggaatagaagta aaagacttcggccgaagttggagaagtggagtggcctttcattctgtcatccacgctatt cggccggaactagtggacctggagaaggtgaaaggaaggcctaaccgagaaaacctggag gaggctttcaccattgctgaaacggaactggggatcccacggctcctggaccctgaagac gttgacgtggataaaccagatgagaagtctattatgacctatgtggcccagtttctgaag cagtatcctgacatccacagtacaggctctgatgggcaagagaatgatgaaatacttcca agtttcccatcttttacaaattctatccaaattcttaagagagaagacaggctaattttg aaggagatgaaagtttggatagaacaatttgaaagagatttgacaagggcacagatgaca gactcaagtttgcaggataaatatcagtcatttaagcatttcagagttcaatatgaaatg aagaggaaacagattgaacacttattgcaaccgttacatagagatggtaaattgtcactt gaccaagcattggtaaaacaggcctgggatagagtgtcctccaggctcttcgattggcat atacaacttgacaagtctcttcctgcacctctgggtaccataggggcctggttatacaga gcagaggtggccctaagagaggaaataaccattcagcaggttcacgaggaaacagccaac acaatacaacggaaacgtgagcaacacaaggatctgcttcaaaacacagatgcccacaaa agagcattccatgaaatctaccggaccaggtctgtgaacgggatcccagtgccgcctgat caattagaggacatggccgagaggtttcattttgtttcctccacatcagagctacactta atgaaaatggaatttctagaattaaagtaccgtctgctctcactgctggttcttgcagag tcaaagctgaagtcttggatcatcaagtatggggggagagattcagtggagctacttctg caaaactacatctcttttatagaaaatagcaagttctttgaacaatatgaagtgacatac cagatcttgaaacagacagctgagatgtatgtcaaagctgatggttcagtggaagaagct gagaatgtgatgaaattcatgaatgaaaccactgcccagtggaggaacctctccgtggaa gtcaggagtgtgcgaagcatgctagaggaagtcatcgccaactgggaccgatacggcaat accgtggctagtcttcaggcttggctcgaggatgctgaaaaaatgctaaatcagtcagaa catgccaaaaaggattttttccgaaatttgcctcattggatacagcagcacacggccatg aatgatgctggcaattttttaatcgaaacgtgtgatgagatggtttcccgtgatctcaaa cagcaattactactgctaaatgggagatggagggagttgtttatggaagtcaagcaatat gctcgagctgatgagttggacagaatgaagaaagaatacaacgattgtgttactatcttg tctgattttgcaactgaagcccataggaaactttcagagcccttagaagtctcttttatg aatgtcaagttattaattcaagacttggaggatattgaacagagggtgcctgtgatggat gctcagtataagatgataacaaagacagcgcacctcattaccaaagagatctctcaagaa gaagctaatgaaatgtttgcaaccatgtctgggctcaaagagcaactaaccaaggtcaaa gactgttactccccactcctttctgagtctcagcagctgttggtaccgttggaggaatta gaaaagcagatgacggccttttatgactcacttgggaaaatcgatgaaattatgacagtt cttgaacatgaggcacaatctagtcctctttttaaacagaaacatcaggacctgttggct tgtcaagaaagctgtaagaaagccatgactcaaattgagaaaggcagtcagagtgttcag aagtttgtgaccctgagcaacgtgttaaagcattttgaccagacgaagctgcagagaaag attgcagatacgcacgttgcttttcagaatatggtaaagaaaactggagattggaagaaa catgtggaaaccaacagccgcttgatgaagaagtttgaggagtctcgagccgagttggag aaggtgctcagggtcgctcaggagggcctggaggaaaagggggacccggaagacctgctg aagagacacaccgagtttttcagtcagctggaccagagggtgctcaatgctttcctgaaa gcgtgtgatgagctcactgacattctgcctgagcaggagcagcggggcctgcaggaagcc gtcagaaagctccacaaacagtggaaggatcttcaagcagaggctccatatcatttgctt catctgaagattgaggtggagaagaacaggttcttagcttctgtggaagagtgcagagct gagctggaccgagagaccaagctggtgccccaggaaggcagcgaaaaaatcatcaaagag cacaggatcttcttcagtgacaagggccctcaccatctctgtgagaaaaggttacagctc attgaagaactgtgtctgaaacttccagtccgggatgcagtccggaacacacctgagacc tgtcacgtgaccctcaaggagctcagagctgctattgaccgcacctacgtgaagctggtg ggagacccagacaagtggaaggattacacgagcagaatttctgagttctcctcttggata tctgcaaaggagacccagttaaaggggattaagaatgagaccattgatactgctaatcaa ggagaagttaaacgtgctctggaggagatcagaagtggtattaccaaaaaaggggagact ctcagctggctgaaatccaggcttaaaattctgattgaagtttcttctgaggatgaagcc caaaagcaaggagatgagctggcaaaattatctagttctttcaaggctctcgggactttg ttgtcagaggttgaaaagatgttaagcaactttggagactgtgtccagtacaaagaaata gtcaaaagttccctggaagagttaatcactggctctaaagaagtccaggaagaagccgag aagatcttggacactgaaaatttgtttgaagcacaacaactactccttcatcaccagcaa aagacaaagagaatcaatgcaaagaagaaggacgtgcaacaacagatcacgcaggctcag aagggagaaggtgggctgcctgggcgagtccaagaggagctgcagaagctggagagcacc ctggacagtgtggagcacagtcgggagaaacaggagcgccgcatccaggtcacattaaga aaatgggagagatttgaaacaaacaaagagacagtggtcagatacctttttcaaacaggt tccagccatgagcgcttcttgagttttagcagtttggaaagcttatcttcagaattggaa cagacaaaggagttttctaaacgaacagaaggtattgcagtccaggctgagaatcttgtg aaggaagcttcagagatcccacttgggcccaagaataagcagctgcttcagcagcaggcc aagtcaatcaaggagcaagttaaaaaattagaagacacccttgaagaagatattaaaacc atggaaatggtgaaaaacaagtgggatcattttggcactaactttgagaccctgtccgtc tggataactgagaaagaaaaagaactcaatgccttggagacgtcatcatctgccatggat acacaaatcaaccaaattaaggtcatgattaaggaaatagaaagtaagatcagcagcatt acaggactagaagaagaagctcagtcttttgctcagtttgttaccactggagaatctgct 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gctttgcaggaacaagcaaggacctatctagatctcctttgctccatgtgtgacctgtca aactcttcagtgaaaaccacagcaaaagacattcaacaaacagaacaaatgattgaacaa aggcttgcccaggcacagaacctaactcagggctgggaggagatcaagcacatgaaggct gagctctggatttacctccaggatgccgatcagcagctgcagaatatgaagaggaggcac tcagaactggagctaaacatcgcacagaacatggtgtctcaagtaaaggattttgttaag aagctacagtgcaaacaggcatcggtgaacactattacagagaaagtggatgagttgacc aagaagcaagagtcccctgaacacaaggaaataagtcatttaaatgaccagtggctggat ctgtgccttcagtccaacaatctgtgcttgcaaagagaagaagatctccagagaacacga gattaccacgaccgtatgaatgttgtcgaagggttcttagaaaaatttactacagaatgg gataacttagccagatctgatgcagagagtacagctgttcacctggaagctttgaaaaag ttggccctggcattgcaggagagaaagaaggccattgaagatctgaaagagcgaaagcag aaaatgatagaacatctgaatttagatgacaaagaattagtcaaagaacagacgagtcac cttgaacaacgctggtttcagctagaggacctcgttaaaagaaaaatccaagtgtccatc accaacctggaggagctcagtgtggttcggtccaggtttcaggagctgatggagtgggca gaagagcaacagcccaacatcgccgaggcccttaagcagagccccccacctgacatggct cagaacctgctcatggatcaccttgccatttgcagcgaactggaggccaaacagatgctc 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gcagaggatcagttccacagcaatctggaagagcttcaaggcctggtagccaacctggac ccactcatcaagccgactggaaaagaggacctagcacagaaaatggcctccctggaagag aagagccagacgataatgcaggattcacatgcccagttagagctcttgcagagatgtgca gctcaatggcaggattatcagaaagcaagggaagaggttattgaattgatgaatgaagct gaaaagaaattgtctgagttttctttattgaagacttcttccagtcacgaagcagaagaa aaattgtcagaacataaggctttagtgtcagtaataaactctttccatgagaaaatcgtg gctttagagggtgaagcttcagaactggaaagaaccggaaatgatgccagcaaagcagcc ataagcaggtcaacaacagctgtctggcagcgttggacgcggctccgcgctgtggcccag gaccaggagaagttactggaagatgcagtggatgagtggacgagctttaacaataaggtt aaaaaagcctctgaagtgattgatcagctgcaagataaattaccgggaagctcagcagag aaggcctcaaaagcagaactcgtaactcttcttgaataccatgacacattcatcntggag ctggaacggcaacagtcggccttagggatgctgcggcagcaagcgctgagcatgctccag gatggagtcacaccatcccctgggggagagccacccacggtgcaggagatcacagccatg caggaccggtgcctgaacatacaggagaaagtcaagaagaatgggaagatagtaaagcaa gagctcaaggaacgagaagtggtggagacacacatcagttcagtaaaatcttgggttcag gaaacaaaggaatacttggggaatccaacaatagaaatagatgctcaacttgaagaactt 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gagtcactcaagccaaaagtccacgcagtgcaggtccgtcagagcgcgctccggatcccc gaggacgtggtcgccagcctgccgctctgccacgcggctctgcacctgcaggaggaggcc agccggctccagcacacggccatccagcagtgcaacatcatgcaggaggctgtggtgcaa tatgaacaatatgagcaagaaatgcagcacctccaggaactcatagaaggagctcacaga gagattgaggataagcctgtggccaccagcaacatccaggaactgcaagcccagatttct cggcatgaggagctggctcagaaaatcaagggctaccaagagcagatcgcctctttgaac tccaagtgcaagatgctgaccatgaaagccaagcacgccaccatgctgctgacggtgacc gaggtggaggggctggcggaggggacggaggacttggacggggagctcctccccgcgacc tcggcccacccctctgtggtcatgatgactgcaggtcgctgtcacactttgctgtcacct gtcactgaggagtctggggaggagggaaccaacagtgagatctcctctccgcctgcttgc cgctccccttcacctgtggctaatacagatgcctctgttaaccaggacatcgcttattac caagccttatctcctgagaggttacagaccgatgctgccaaggttccccccagcacgctg ccaccccaagagctctatgaaccgggactggagccttccgctactgcgaagctggacgat ctgcagcgctcttgggaaaccttaaagaatgtgatcagcgagaagcagcgcacactctat gaagccttggaacgccagcagaagtaccaggactccctccagtccatctccacgaaaatg gaggccatcgagatgaaactcagtgagagtctggagcagggcaggagtcccgagagccag atggccgaacatcaggctctgatggatgagatcctcatgctccaagaggagatcagcgag ctgcagtcggccctcgcagacgagctggcgtctgagtccccagagtccgagccggcagag cagctggccctgcagtccacgctcaccgtcttggcggagcgaatgtccaccatcaagatg aaggcatccgggaagcggcagcttctggaggagaaactcaacgatcagctggaggaacag agacaggaacaagccctgaacaggtatcgctgtgaagctgatcagctggaccactggctc ttgagcacgaaggccactctggacattgccctggggtcacccaaggagcccatggacatg gaggcccagttagtggactgccagaatatgctggtggaaatagagcagaaggtggtggcc ttatcagagctctcggtccacaatgaaaacctgctgctggagggcaaggctcacacaaag gacgaggccgagcagctggcggtgaagctgagaaccctcaaggggagcctcctggagctg cagagggcgctgcaggacaggcaactccacatccaggggacagcccaggagaaggaggag agtgatgctgacctggctgccactcagagccccggggttcaggaatggctggctcaagct cggagcgcgtggacccaccagcgacagagcagcctccagcaacaaaaagagttggaacag gaattggcagagcagaagagcctcctccagtcagtagccagccttggagaggaaattcta acgcaacactcagctgcagagacctctggtggtgttggcgaaaaacctgatgtgttatcc caggagttggggatggaaggggagaaatcacctgctgaagaccagatgagaatgaaatgg gaaagcctacatcaagaatttagcaccaagcagaaactacttcagaatgttctggagcag gaacaagagcaaatgctctacagcaggcccaatcggctcctgtctggcgtgccactgtac aaaggcgacgggcaggcccaggataaatctgcggtgacgtctttgctggatggattgaac caggtcttcgaggaggtttcatcccagggtggagggacaaagaagcagaacattgacttg gagcagaagttgtatgatggggtctcggccacctctacctggctggatgatgtagaggaa cggttatttgttgccacagcccttttaccagaagagacagaaacttgcatctttaaccaa gagactcttgccaaagatattaaagaaatgtctgaagaaatggataagaacaagaacttg ttttcccaagcctttccggagaatggtgataaccgagatgttattgaagacactttgggt tgtctcttgggcaggttatctttgctagactcagtagtaaatcagcgatgtcatcagatg aaggaaagacttcagcagatactaaatttccagaatgatctgaaggtgctagttacatca ctggctgaccacaaatacatcattctgcagaagctggcgaaaatgtttgaacaacctgtg gcagagcaaatagaggcaatacagcaggctgaagatgggctaaaggaattagatgcagga atcattgaattaaaaaggcatgctgacaagttgcagattgagcagccgtccatgcaagaa ctctccaaactccaggacatgtatgatgaactcatgatgactattggctcccggcggagc gggctgaaccagaatcttgccctcaagagtcagtacgaaagagccttgcaggatctggcc gacctactggaaacaggacgagagaagacggcaggagaccagaaaattatcgtgtcttcc aaagaggaaatccaacaactacttgataaacataaggaatactttcagggtctggaatct cacatgatcttgaccgaaaccctcttcagaaagatcatcagctttgcagtcccacgggaa actcagttccacacagacctgatggcgcaggcttccgctgtgctcaaaggggctcacaag aggggtgtggagctggagtacatcctcgagacatggtcccaactggagaaggagcactgg gagcttagccggcagctggaggtggtggagagcagcaccccaagcgtgggtttggtggag gagagcgaagacaggcttatcgaccggatcgcactctaccaggtcagcgtccagatgaca gtgtggtgtaagaagttgccacatcgctttttgaagctttcccttggttttaacagatct actcaaactttcaatccaatattttccttcagcaagtgttttccacttcccaaattatat caggtaatagatgatggaaaacgacttctgatatctgttagctgttcagatctggaaagc cagctcaatcaacttggagagcactggttaagtgataccaacaaagtgtctaaggaactt cacagattggaaacaatattgaaacactggaccagatatcaaagtgaatctgcagatcta atccactggttacagtctgcaaaagacaggctggaattttggactcaacaatctgtgaca gtcccacaagaactggaaatggtccgtgatcacctgaatggctttctggagttttccaaa gaggtggatgccaagtccacgctaaaatcatctgttctgagcactggaaatcagcttctt cgattaaagaaagtggacacagctgccttgcgttctgagctgtcccacattgatggccag tggaatgacctgctgacaaatattccagccgtacaggaaaagcttcaccagctccaaatg gataaactaccttctcgccacgccatttccgaagtcatgacttggatttctcttatggaa agtgttattcaaaaggatgaagagaatattaaaaattccatcggttacaagacaattcat gagtaccttcagaaatataagggttttcagatcgacattaactgtaagcagctgactgtt gattttgtgaatcagtctgtgctacagatcagcagtcaggatgtggaaagtaaacgcagc gacaagactgattttgctgagcgacttggagcaatgaataaaagctggcaaatcctgcag ggtctggtcactgagaagattcagttgttggaaggcttattggaatcttggtcagaatat gaaaataacgtacaatgtctgaaaacgtggtttgaaacccaggaaaagagactgaaacaa caacatcgcattggagaccaggcttcagttcagaatgcaatgaaagactgtcaggatctg gaagacttgattaaagcaaaagagaaagaggtagagaaaattgagcagaatggacttgct ttggttcagaacaagaaagaagaagtatctggcattgtcaggagcacgcttcaggagctc aaccaaacttgggcaaatttagaccacatggttggccaactcaagatcctgttgaaatcc gtgcttgaccagtggagccaccataaagtggcatttgatgagataaacagttgcctcatg gagtcccgatactctctttctcgattctgtctactcactggctctttagaagctgtgcaa gttcaggtggacaatcttcagaatcttcaagatgatctagaaaaacaggaaaagagcttg cagaaatttggctctgtgaccaaccaacttctaaaagagtgtcacccacctgtgacagaa actcttactaatacactaaaagaagtcaacatgagatggaataacttgctggaagagatt gccgagcagctgcgtgccagcaaggccctacttcagctttggcagagatacaaggactac ttcaaacagtgtgctgctacagttcaacagcaggagggacgaaccaacgagttcttgaag gcagccaccgacaaggacatcggtgatgacgaagttgccacctggatccaagattgcaat gacctcctcaaaggattggggccaattcaggattctcttgtagttcttcatgagctggga gggcaactcaagcaacaagtggacgcttcggcagcatcagccattcaatccgattggctc tctttgaggcaacaattacatgctctcgaacaggctctctgcaaacagcagactgtgtta caggctggcgttcttgactatgaaacctttaccaagagtttagaagctttggagacctgg atagtagaagctgaagaaatattacaagggcaggaccctagccactcctctgacctctcg accatccaggaaaggatggaggagctgaagggacagatgctgaaattcagtagcatggtc ccagatttagaccgtctgaatgagcttggatacaggctgcccctgaacgataaagaaatc aaaaggatgcagaatctcaatcggcactggtctctgatctcctcccagactacggaaaga ttcagtaagttacagtcatttttgctacaacatcagactttcttggaaaaatgtgaaaca tggatggaattcctagttcaaacggaacaaaagttagcagtagagatttcaggcaattat cagcatcttttggagcagcagagagcacatgagttgtttcaagcagagatgttcagccgt cagcagattttgcactcaatcatttttgatggacagcaccttctagaacaaggtcaagtt gatgacagggatgagttcaacctgaaattgaccctcctcagtaatcagtggcagggggtg atccgccgggcccagcagaggcggggcatcattgacagccagatccaccagtggcagcga tacagggagatggcagaaaagctccgtaaatggctggtggaggtgtcctgtctgcccgtg agtggtctggggagtgtccagataccactgcagcaggcaagggccctctttgatcaagtg cagttcaaagaaaaagtgttcctgcggcaacaaggcagctacatcctcaccgtggaggct ggcaagcagcttctgctttcagccgacagcggggctgaggccaccctgcaggccgaactc gctgagatccaagagaaatggaagtcagcaagtgtgtgtctggaggagcagaagaaaaaa ctggccggcttgctgcaggactgggaaaaatgtgagaacggaatagctgattctctggag aaactacgaactttcaaaaagaggctttcccagcctctcccagatcatcacgaagagctc catgcggagcagatgtgctgcaaggaattggaaaacacagttgggagctggacagatgac ttggcacagctgacactgctgaagaaggctctctgtgcttacatcagtgcagatgatatc tccatccttaacgaacgcatggagcttctgcagaggcagtgggaagaactatgccaccag ctctccttaaggcgacagcaagtaagtgagaggctgaacgagtgggccgtcttcagtgaa aagaacaaggagctttgcgaatggctgactcagatggaaagcaaggtctctcagaatgga gacattctcattgaagaaatgattgagaagctcaggaaggattatcaagaggaaattgca attgcccaagagaacaaaatacagctccagcaaatgggagaacggctggctcgagccagc catgaaagcaaagcgtctgagattgagtacaagcttggcaagatcaatgaccggtggcag caccttctggacctcatggcagccagggtaaagaagctgaaggagactctggttgcagta caacagctggataagaacatgagcagtctgaggacgtggttagcccacatcgagtcagag ctggccaaacccatcgtctacgattcctgtgactcagaagaaatacagaaaaagcttaac gagcagcaggagcttcagagagacatcgagaaacacagcacaggagtggcctctgtgctc aacctgtgcgaggtccttctccatgactgtgatgcctgcgctacagacgccgagtgcgat tccatccagcaggctacgcgaaacctggaccgccgatggagaaacatctgtgccatgtcc atggaaaggaggctcaaaattgaagagacatggcgattgtggcagaagtttctggatgac ttttctcattttgaagattggctcaagatctcagaaaggacagctgcctttcccagctct tccggggtgctctatacagttgccaaggaggaactaaagaaatttgaggctttccagcga caggtccatgagagcctgacccagctggagctgatcaacaagcagtaccgccgcctggcc agagagaaccgcacggacgcggccggcagcctcaaacagacggttcacaaaggcaaccag agatgggacaatctgcagaagcgcgtcacctccatcctgcgcagactcaagcatttcatt ggccagcgggaggagttcgagacggcacgggacagcattctggtgtggctgacggagatg gatctgcagctcaccaacatcgagcacttctctgagtgtgacgttcaagctaaaataaag cagctcaaggccttccagcaggaaatctcattgaaccacaataagattgaacagataatc gcccaaggagaacagctgatagagaagagtgagcccttggatgcggccgtcattgaggaa gagctggatgagctccgacgttactgtcaggaggtctttggacgcgtggaaagataccat aagaaactgatttgcctgcctctcccagatgatgagcacgacctctctgaccgggagctg gaactggatgaggctggaactctgtcagacctccactggcgggacacctccacggacggc gtgctctccccgcagccttcctccaacccctccctctcactcgcccagcccctccggagt gagaggtctggacgagacacccccgccagtgtggactccatccccctggaatgggaccat gactatgacctcagccgtgacctggagtccgcggtgtccagaactctgccgtctgaggac gaagagggtccggaagataaagatttctacctcaggggagctgttggcttatcagatgta gtgatccctgaaaatcccgaggcctatgttaaactcacagaaagtgcaatcagaaattcc tctggggaccctggtgccttggagtcacagatccaacagctgggcaaagccttggatgac agccgctttcagatgcagcaaacagagaatatcatccacagcaaaacgcccacaggacca gagctagactccggctacaggggctacatgaaactgctgggtgaatgcagtggcagcata gactcagtgaaaagactggagcacaagctgaccgaggaagaggaccattttcctggcttt gttaacttgaatagcactgaaacccaaacagctggcgtgattgaccgctgggaactcatc caggcagaggccctgagcaaggagctgaggatgaaacagaagccccagaggaggcagcag ttggactcagatctgaatagcgttctgacctggcttagggagacggagggcgacctggaa cagcttcagcgcctacagctcagcaccgacatccagtccatcgcgctccaaatccagaag ctgaaggagctccagaaagctgtggaccagcgcaaagccatcatcctgtccatccatctg tgcagctctgagttcactcagcctggccgggaggagagccaggatcttcaggaccgcttg tcccagatgaacggacggtgggaacgcgtgtgctccctgctggaggagtggcggggtctt ctccaggacgcgctcatgcagtgccaggattttcatgaaatgagtcacggtttgctgctt atgctggagaacatcgacagaaggaaaaatgaaattgtccccattgattctaaccttgat gcagaaatacttcaggaccatcacaaacagcttaagcaaataagacatgagctgttggaa tctcaactcaaagtggcctcactgcaagacatgtcttgccaactgttggtgaatgctgaa ggcacagactgtttggaagccaaagaaaaagtccacgtgattggaaatcgactcaaactt ctcttgaaggaggtcagtcgtcatatcaaggagctggagaagttattagacatgtcaagc agtcagcaggatctgtcttcctggtcttctgctgacgaactggacacctcaggatctgtg agtcctacctcgggaagaagtaccccaaacagacagaaaacgccacgaggcaaatgtagt ctctcacagcctggaccctctgtcaacagtccacatagcaggtccataagaggtggctcc gattcctccctttctgagcctcggccagcccggtccggccgagccttcctgttcagagtc ctccgagcggctcttcctcttcagctcctcctgctgcttctcattgggctggcctgccta gtccccatgtcggaggaagactacagttgtgccctctccaacaattttgcccgatcattc caccccatgctcagatacaccaacggccctcctcctctctga

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