Bison bison bison (American bison): 104989735
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Entry
104989735 CDS
T08726
Symbol
LRRK2
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2 isoform X1
KO
K08844
leucine-rich repeat kinase 2 [EC:
2.7.11.1
]
Organism
bbis
Bison bison bison (American bison)
Pathway
bbis05012
Parkinson disease
bbis05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
bbis00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
104989735 (LRRK2)
05022 Pathways of neurodegeneration - multiple diseases
104989735 (LRRK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
bbis01001
]
104989735 (LRRK2)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
bbis04131
]
104989735 (LRRK2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
bbis04147
]
104989735 (LRRK2)
Enzymes [BR:
bbis01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
104989735 (LRRK2)
Protein kinases [BR:
bbis01001
]
Serine/threonine kinases: TKL group
LRRK family
104989735 (LRRK2)
Membrane trafficking [BR:
bbis04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
104989735 (LRRK2)
Exosome [BR:
bbis04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
104989735 (LRRK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
ARM_LRRK2
Beta-prop_LRRK2
ANK_LRRK2
Pkinase
PK_Tyr_Ser-Thr
Roc
LRR_8
LRR_4
COR
Ras
LRR_14
LRR_9
Arf
Beta-prop_EML_2
WD40_CDC20-Fz
LRR_13
Beta-prop_RSE1_2nd
T2SSE
Ank_2
Kdo
nSTAND3
LRR_6
WDR55
G-alpha
GTP_EFTU
WD40_Prp19
AAA_22
AAA_16
PduV-EutP
ABC_tran
WD40_like
Beta-prop_BBS7
NACHT
AAA_7
MobB
MMR_HSR1
TrwB_AAD_bind
AAA_29
cobW
FtsK_SpoIIIE
TniB
AAA_23
Arm
Motif
Other DBs
NCBI-GeneID:
104989735
NCBI-ProteinID:
XP_010839805
Ensembl:
ENSBBBG00000009130
UniProt:
A0A6P3HMS4
LinkDB
All DBs
Position
Unknown
AA seq
2527 aa
AA seq
DB search
MASGSCQGCEEEDEESLKKLIVRLNNVQEGKQIETLVQILEDMLVFTYADHASKLFQDKN
VHVPLLIVLDSYMRVASVQQVGWSLLCKLIEICPNTMQSLMGPHDIGHDWEVLGVHQLIL
KMLTVHNASVNLTTVGLKALDLLLTSGKITLLILDEENDIFLLIFDAMRTFSASDEVQKL
GCKVLHVLFERVSEEQLTEFVENKDYMILLSALKNFEDEEEIVLHVLHCLHSLAIPCSNV
EVLMSGNVRCYNIVVEAMKAFPISEKIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAV
QQYSENAVLQIAALSCLALLTETIFLNQDLEEKNENQENDDDEEDKLFWLEACYKALTWH
RKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGQFPAHREVMLSMLMHSSSKEVFQASAN
ALSTLLEQNVNFRKILLSKGIYLNVLELMQKHMHSPEVAESGCKMLNHLFEESSTSLDTM
AAVVPKIITVMKSHETSLSVQLEALRAMLHFIVPGIPEEYREDTEYQHKLNMIEKQCFRN
DIHKLVLAALNRFIGNPGIQKCGLKVISSIIHFPDALEVLSLEGAIDSVLHTLQMYPDDQ
EIQCLGLSLIGCLITKKNLCMGTGNLLAKILISTLQRFKDIGEVQIKGFQTVLTMLELSV
SFSKLLVHYSFDSVIFHQLSSSITEQKDQQFLNLCCKCFAKLAIDNELKSVMLEKACDQN
NSIMVECLLLLGADANRAKEATSLICQVCEKASSPKLVELLLNSGSREQDVRKALTISIG
KGNSQIISLLLRRLALDLANNSICLGGFCMGKIDPSWLGPLFPDKTSYLRKETNIGSTLA
RMVLRYQMKSSVEEEAGSGSKGNFSEEMVDKFDEWTFVPESYVDSVFGQSDDLDSEGSEG
SFLVKTKSNSISVGEFYRDPALQRCSPNLQRHSSSLGPIFDHEDLIKRKRKIFSSDDSLR
ASKFQSHMKHSESMSSLPSEREYITSLDLSANELKDVDALSQNSCISGHLEHLEKLELHQ
NALTSFPQQLCETLKCLTHLDLHSNKFTSLPTYLLKMNCIANLDVSRNDIGPSVVLDPAV
KCPTLKQFNLSYNQISSLPANLGDVVEKLEQLILEGNKISEICSPLSLKELKILNLSKNH
ISSLSEDFLETCLKVEILSAKMNFLATMPFLPSSITSLKLSQNRFTCVPEAILHLPHLRS
LDMSSNDIRYLPGPVHWRSLNLRELLFSHNQISILDLSEKACAWSRIEKLHLSHNKLKEI
PPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHVGCKAKDIIR
FLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKIKKSDLGMQGATVGIDVKDWPIQI
RGKGKKDLILNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKA
RASSSPVILVGTHLDVTDEKQRKACISKITKELLNKRGFPAIRDYHFVNATEESDALAKL
RKTIINESLNFKIRDQPVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVREH
QLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKVMAQILTVKVEGFPK
HPKGIISRRDVEKFLSKKKRFPKNYMAQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVI
ELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYL
NWSPEAYCLVGSEVLDHHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDI
CGEGETLLKKWALYSFNDGEEHQKILLDHLMKKAEEGDLLVNPDQPRLTIPISQIAPDLI
LADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQE
LVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKTSLTRTLQHRIVLHVAD
GLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRA
PEVARGNVIYNQQADVYSFGLLLYDILTTGGRIAEGLKFPNEFDELAIQGKLPDPVKEYG
CAPWPMVEKLIKKCLKENPQERPTSAQVFDILNSAELICLMRRISIPKSFTVECMVATNH
NSKNVRIWLGCGHTDKGQLSFLDLNTERYTSEEVTDSRILCLALVYLPVEKESWIVSGTQ
SGTLLVINTEDGRKRHTLEKMTDSVTCLYCNSFSKQSKQKTFLLVGTADGNLAIFEDKSV
KCKGATPLKILNIGNVSTPLMCLSESVNLTEKNIMWGGCGTKVFSFSDDFTIQKLIETRT
NQRFSYASFCDSNIIAVVVDTALYVAKKNSPFVEVWDKKTEKLCELIDCVHFLKEELVRV
SKELKHKMSYSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRIIRIIHNFCDSVRVMMT
AQLGSLKNVMLVLGYNRKSAEGTQHQKEIQSCLSVWDINLPHEVQNLEKHIEVRKELAEK
MRRTSVE
NT seq
7584 nt
NT seq
+upstream
nt +downstream
nt
atggccagtggcagctgccaggggtgcgaggaggaggacgaggaatctctgaagaagttg
atagttaggctgaacaatgtccaggaaggaaaacagatagagacgctggttcaaatcctg
gaggatatgctggtgtttacttacgccgatcacgcctccaagttatttcaagacaaaaat
gtccacgtgcctctgttgatcgtcttggactcctatatgagagtcgctagtgtgcagcag
gtgggttggtcacttttatgcaaattaatagaaatctgtccaaatacaatgcagagctta
atgggaccccatgatattggacatgattgggaagtccttggggttcaccaattgattctt
aaaatgctaacagttcataatgccagtgtcaacctgacaacagttggattgaaggcctta
gatcttctcctaacttcaggtaaaatcactttgctgatattggatgaagaaaatgatatt
ttcttgttaatcttcgatgccatgcgcacattttcagccagtgatgaagtccagaaactt
ggatgtaaagttttacatgtgctgtttgagagagtttcagaggagcaactgactgaattt
gttgagaataaagattatatgatattgctcagtgcattaaaaaattttgaagatgaagag
gaaattgtgctccatgtactgcactgtttacattccttagcaattccttgtagtaatgtt
gaagtcctcatgagtggcaatgtcaggtgttataatattgtggtagaagccatgaaagca
ttccctatcagtgaaaaaattcaagaagtaagttgctgcttgctccataggcttacgtta
ggtaacttttttaatatcctggtattaaatgaggtacatgagtttgtggtgaaagctgtg
cagcagtattcagagaatgcagtgttacagatcgcagctctcagctgcttagcactcctc
actgagaccattttcttaaatcaagacttagaggaaaagaatgagaatcaggagaatgac
gatgatgaagaagataaattgttttggctggaagcctgttacaaagcattaacttggcat
agaaagaacaagcatgtgcaggaggctgcctgttgggccctgaataatctccttatgtat
caaaacagtttacacgagaagattggagatgaagatggccagttcccagctcacagggaa
gtgatgctgtccatgctgatgcactcttcatcaaaagaagtcttccaggcatctgcaaat
gctttgtcaactctgttagaacaaaatgttaattttagaaagatcctgttgtcaaaagga
atatatctgaatgtattggagttaatgcagaagcatatgcattctcctgaagtggctgaa
agtggctgtaaaatgctaaatcatcttttcgaagaaagtagcacttccctggatacaatg
gcagcagtggttcccaaaataataacagtcatgaaaagtcatgagacatcattatccgtg
cagctggaagcacttcgagctatgttacattttatagttccaggcatcccggaagaatac
agggaagatactgaatatcagcataagctaaatatgattgaaaagcagtgtttcaggaat
gatattcacaaattggtcctggcagctttgaacaggttcattggaaatcctgggattcag
aagtgtggattaaaagtaatatcatctataatacattttcctgatgcattagaggtatta
tccctggaaggtgctattgattcagtgcttcatacactgcagatgtatccagatgaccaa
gaaattcagtgtctgggtttaagtcttataggatgtttgattacaaagaagaatttatgc
atgggaactgggaatctgctggcaaaaattctgatttccaccctacaacgatttaaggat
attggtgaagtacagataaaaggatttcagacagtcttgacgatgctggaattgtcagtg
tctttttccaagctactggtgcattactcctttgattcagtaatattccatcagttgtcc
tccagtatcacagagcaaaaggatcaacagtttctaaacctttgttgcaagtgctttgca
aagttggccattgataatgagttaaaaagtgtgatgctggagaaagcatgtgatcagaat
aacagcatcatggttgaatgcctgcttctgttgggagcagatgccaatcgagcaaaagaa
gcaacttctttgatttgtcaggtatgtgagaaagcaagcagtcccaaactggtagaattg
ttactgaatagtggatctcgtgagcaggatgttcggaaagctctgacaatcagcattggg
aaaggcaacagccaaataatcagcttactcttgaggaggcttgccctggatctggccaat
aatagcatctgtcttggaggattttgtatgggaaaaattgacccttcctggcttggtcct
ttatttccagataagacatcttatttaagaaaagagacaaatataggatccaccctggca
aggatggtgctcagatatcagatgaaaagttctgtggaggaagaagctggctcaggcagc
aaagggaatttttctgaagaaatggttgataaatttgatgaatggaccttcgttcctgag
tcttacgttgacagtgtgtttggtcaaagtgatgacctggatagtgaaggaagtgaaggc
tcatttcttgtgaaaacaaaatcaaattcaattagcgtaggagaattttaccgagatcct
gccttgcagcgttgctcaccaaatttgcaaagacattccagttcattgggacccattttt
gatcatgaagatttaataaagagaaaaagaaaaatattttcatcagatgattcactcaga
gcatcaaaattccagtcccatatgaagcattcagagagcatgtcttccctgccttctgag
agagaatatattacatcattagacctttcagcaaatgaactaaaagatgttgatgccctg
agccagaactcctgtataagtggtcatttggagcatcttgaaaagctggagcttcaccag
aatgcactcacaagttttccacaacaactatgtgaaactctgaaatgtttaacacatttg
gatctgcatagtaataaatttacatcgcttcccacttacttgttgaaaatgaattgtatt
gctaaccttgatgtctcccgaaatgacattggaccctcggtagttttggaccctgctgtg
aagtgtccgaccttgaaacagtttaacttgtcgtataatcagatatcttctcttcctgcg
aaccttggtgatgtggtagagaaattggaacagctcattttagaaggaaataaaatatca
gaaatatgttcccctttgagcctgaaggaactgaagattttaaaccttagtaaaaaccac
atttcatctttatcagaggacttccttgagacttgtcttaaagtggagattttaagtgcc
aaaatgaattttcttgctactatgccttttttgccttcttctatcacaagcctaaaatta
tctcaaaacagattcacgtgtgtcccagaagcaattttacatctcccacacctgcggtcc
ttagatatgagcagcaatgatattcgatatctaccaggtcctgtgcactggagatctttg
aacttaagggaactcttgtttagtcataatcagatcagtatcttggacttgagtgaaaaa
gcatgtgcatggtctagaatagagaaactacatctttctcataataaactgaaagagatt
cctcctgagattggctgtcttgaaaatctgacatctcttgatgttagttacaacttggaa
ctgagatcctttcccaatgaaatggggaaattaagcaaaatatgggatcttcctttggat
gaactgcatcttaattttgattttaaacatgtaggatgtaaagccaaagacatcataagg
tttcttcagcagcggttgaaaaaggctgtgccctataaccgaatgaaacttatgattgtg
ggaaatactgggagtggcaagaccaccttattacagcaattaatgaaaatcaagaaatca
gatcttgggatgcaaggtgccacagttggcattgatgtgaaagactggcccatccaaata
agaggcaaagggaagaaagacctcattctgaatgtatgggattttgcaggtcgtgaggaa
ttctacagcactcatccccactttatgacccaacgagccttgtatcttgcagtctatgac
ctcagcaaagggcaagcagaagttgatgccatgaagccttggcttttcaatataaaggcc
cgtgcttcttcttcccctgtgattctagttggcacacatttagatgttactgatgagaag
cagcgcaaagcctgtatcagtaaaattaccaaggaactcttgaacaaacgagggtttcct
gcaatacgagattaccactttgtgaatgccactgaggaatccgatgctttggcaaaactt
cggaaaaccatcatcaatgagagccttaatttcaagatccgagatcagcctgttgttggg
cagctgattccagactgctacgtagaacttgagaaaatcattttatcagagcgtaaaaat
gtgccaattgaatttcctgtaattgaccggaaacgattattacaacttgtgagagaacat
cagctgcagttagatgaaaatgagcttcctcatgcagttcactttctaaatgaatcaggg
gtccttcttcattttcaagacccagcattgcagttaagcgacttatattttgtagaaccc
aagtggctttgtaaagtcatggcacagattttgacagtgaaagtggaaggctttccaaaa
catcctaagggaattatttcacgtagagatgtggaaaaatttctttcaaagaaaaagaga
tttccaaagaactacatggcacagtactttaaactcctagaaaaattccagattgccttg
ccaattggagaagagtatttactggttccaagcagtttgtctgaccacaggcctgtaata
gagcttccccattgtgagaactctgaaattatcattcgactgtatgaaatgccttatttt
ccaatgggcttttggtcgagattaatcaatcggttgcttgaaatttcaccttacatgctt
tcaggaagagaacgagcacttcgcccaaacaggatgtattggcggcaaggcatctacttg
aattggtctcctgaagcttactgcttggtaggatctgaagttttagatcatcacccagag
agtttcttaaaaattacagttccctcttgtagaaaaggctgtattcttttgggccaagtt
gtggaccacattgattctctcatggaagagtggtttcctggattattggagattgatatt
tgtggtgaaggagaaactctgctgaagaaatgggcattatatagttttaatgatggtgaa
gagcatcaaaaaatattgcttgaccacttgatgaagaaagcagaagaaggagacctccta
gtaaatccagatcaaccaaggctcacaattccaatatctcagattgctcctgatttgatt
ttggctgatctgcctagaaatattatgttgaataatgatgaactggaatttgaacaagct
ccagagtttctcttaggtgacggcagttttgggtctgtttatcgagcagcctatgaagga
gaagaagtggctgtgaagatttttaataaacatacatcacttaggctgttaagacaagag
ctggtggtgctctgccacctccaccatcccagcttaatatctttgctggcagctgggatt
cgtcctcgaatgttggtgatggaattagcctccaagggttccctggaccgcctgcttcag
caagacaaaaccagtcttaccagaacgctgcagcacagaatcgtgctgcatgtggccgat
ggcttgagatacctccattcggccatgattatataccgtgacttgaagccccacaatgtg
ttgcttttcaccttgtatcccaatgctgccatcatcgccaagattgcggactatgggatt
gctcagtactgctgtagaatggggataaaaacatcagagggcactccaggttttcgtgca
cctgaagttgctagaggaaatgttatttataaccaacaagctgatgtttattcatttggt
ttgctactttatgacattttgacaactggaggtagaatagcagagggtttgaagtttcca
aatgagtttgatgaattggcaatacaagggaaattacccgatccagttaaagaatatggt
tgtgccccatggcctatggttgagaagttaattaaaaaatgtttgaaagaaaatcctcaa
gaaagacccacttctgcccaggtctttgacattttgaattcagctgagttaatctgtctg
atgagacgtatatcaatacctaaaagctttactgttgaatgcatggttgctacgaatcat
aacagcaagaatgtgaggatttggctgggctgtggacacactgacaaaggacagctctcg
tttcttgacttaaatacagaaagatacacttctgaggaagttactgatagtagaattctg
tgccttgccttggtgtatcttcctgttgaaaaggaaagttggattgtgtctggaacacag
tctggcacgctcctcgtcattaatactgaagatgggagaaagaggcatacccttgaaaag
atgactgattctgttacttgcttgtattgcaattccttttccaagcaaagcaagcaaaaa
actttccttttagtgggaactgctgatggcaacttagcgatttttgaagataaaagtgtt
aagtgtaaaggagccactcctttgaagatactcaacataggaaatgtcagcactccactg
atgtgtttgagtgaatctgtgaacttaactgaaaaaaacattatgtggggaggatgtggt
acaaaagttttctcattttctgatgatttcaccattcagaaactcattgagaccaggaca
aatcagcgattttcctatgcatctttctgtgattccaacatcatagcagtggtggtagac
acagctctctatgttgctaagaaaaatagcccatttgtggaagtgtgggataagaagact
gaaaaactctgtgaactaatagattgtgtgcactttttaaaggaggaactggtcagagta
agcaaggaattgaaacacaaaatgtcttattctgggagagtgaagactctctgcctccag
aagaacactgctctctggataggaactggaggaggccatatcttactccttgatctttca
actcgtcggattatacgtataattcacaacttttgtgattctgttagagtcatgatgact
gcacagttaggaagccttaaaaatgtcatgctggttttggggtataaccggaaaagtgct
gaaggtacacaacaccaaaaagagatacagtcttgcttgtctgtttgggacatcaatctt
ccacatgaagtgcaaaatttagaaaaacatattgaagtaagaaaagaattagctgaaaaa
atgagaagaacatctgttgaataa
DBGET
integrated database retrieval system
