Bison bison bison (American bison): 104991623 Help Entry 104991623         CDS       T08726                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism bbis  Bison bison bison (American bison) Pathway bbis04020   Calcium signaling pathway bbis04371   Apelin signaling pathway bbis04713   Circadian entrainment bbis04921   Oxytocin signaling pathway bbis04970   Salivary secretion bbis05010   Alzheimer disease bbis05012   Parkinson disease bbis05020   Prion disease bbis05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:bbis00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     104991623 (RYR3)    04020 Calcium signaling pathway     104991623 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     104991623 (RYR3)   09154 Digestive system    04970 Salivary secretion     104991623 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     104991623 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     104991623 (RYR3)    05012 Parkinson disease     104991623 (RYR3)    05020 Prion disease     104991623 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     104991623 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:bbis04040]     104991623 (RYR3) Ion channels [BR:bbis04040]  Voltage-gated cation channels   Ryanodine receptor    104991623 (RYR3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 EF-hand_5 Motif Other DBs NCBI-GeneID:  104991623 NCBI-ProteinID:  XP_010842475 Ensembl:  ENSBBBG00000001764 UniProt:  A0A6P3HV73 LinkDB All DBs Position Unknown AA seq 4872 aa AA seqDB search MAEGGEGGEDEIQFLRTEDEVVLQCIANVHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVP PDLCVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAILLRHSFSGMYL TCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSER YLHLSISNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTIPSTD QNDSQHRRIYYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTED QGLILQDRGKSDTKSTAFSFRASKEIKEKLDSSHKRDIEGMGVPEIKYGDSVCFVQHIAS GLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQREESQAARIIRNTTALFSQ FVSGNSRTAAPVTLPIEEVLQTLHDLIAYFQPPEEGMQHEGKQNKLRSLKNRQNLFKEEG MLALVLNCIDRLNIYNSIAHFAGIAREESGMAWKEILNLLYKLLAALIRGNRNNCAQFSN NLDWLISKLDRLESSSGILEVLHCILIESPEALNLIAEGHIKSIISLLDKHGRNHKVLDV LCSLCLCDGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKW YFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLW SGRIPRAVASINQHLLKSDDVVSCCLDLGAPSISFRINGQPVQGMFENFNTDGLFFPVVS FSAGVKVRFLLGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDAEGIRDLLGT TQFLSQASFIPCPIDTSQVVLPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKR QHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEDELKKVKLPKNYMMS NGYKPAPLDLSDVKLLPPQEVLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLV PYSLLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADPAVEKVSIDKIRFFRVERSY AVRSGKWYFEFEVVTGGDMRVGWARPGCRPDIELGADDQAFVFEGSRGQRWHQGSGYFGR TWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIDNGFVPICSLGLSQIGR MNLGMDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPQIEVVRID GTMDTPPCLKVTHKTFGTQNSSATMIYCRLSVPVECHSSFSHSPCMDSDAFQKRKQMQEI LSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTLGDERGRVHE SVKRSNCYMVWGGDIVATSQRASRSNVDLEIGCLVNLAMGMLSFSANGRELGTCYQVEPN TKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFKSEEKNPVPQCPPRLDVQTIQPVLW SRMPSSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDILELCEQEDLMRFHYH TLRLYSALCALGNSRVAYALCSHVDLSQLFYAIDNKYLPGLLRSGFYDLLISIHLASAKE RKLMMKNEYIIPITSTTRKIRLYPDESKRHGLPGVGPRTCLKPGFRFSTPCFITTNEEHQ KQSPEIPLELLKMKALGMLTEAVQCSGAHIRDPVGGSVEFQFVPVLKLIGTLLIMGVFDD DDVRQILLLIDPSVFGEHSGETEEGAEKEEVTQVEEKAVEAGEKASREAPIKGLLQTRLP ESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQENQKFRYNELMQALNMSAALTA RKTREFRSPPQEQINMLLNFQLGENCPCPEEIREELYDFHEDLLLHCGVPLEEEEEEEED SSWTGKFCALVQRIKGPPKPEKEQPTEEEERCPTTLKELISQTMIRWAQEDQIQDAELVR MMFNLLRRQYDSIGELLQALRKTYTISQASVSDTISLLAALGQIRCLLSVRMGKEEELLM INGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGAEKLQIAFPKMVASCCRFLCYF CRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALGLEEPDLE KVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKL LIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQGYKREVSTEDDEDEEEIVH MGNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLP SLNKDGSVSEPDMAANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLD TVSLSTTEAALALNRYICSAVLPLLTRCAPLFAGTEHYTSLIDSTLQTIYRLSKGRSLTK AQRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLNEYCKMPLKLLTNHYEQCWKYYCL PSGWGSYGLAVEEELHLTEKLFWGIFDSLSHKRYDPDLFRMALPCLSAIAGALPPDYLDT RISATLEKQVSVDADGNFDPKPINTVNFSLPEKLEYIVTKYAEHSHDRWACDKSQNGWKY GISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEALVQQRE NEKLRSVSQASQGNSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGG GSHPLLVPYDTLTAKEKFRDREKAQDLFKFLQVNGIVVSRGMKDMELDASSMEKRFAYKF LKKVLKYVDSAQEFIAHLEAIVSSGKNEKSPHDQEIKFFAKVLLPLVDQYFISHRLYFLS SPLKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTLDTRT VMKSGSELVKAGLRAFFENAAEDLEKTLENLKLGKFTHSRTQIKGVSQNINYTTVALLPI LTSIFEHVAQHQFGVDLLLGDVQLSCYHILCSLYSLGTGKNIYVERQRPALGECLASLAA AIPVAFLEPTLNRYNPLSVFNTKTPRERSILGMPDTVEEMCPDIPQLEGLMKEINDLAES GARYTEMPHVIEVILPMLCNYLSYWWERGPEHLPPSAGPWCTKVTSEHLSVILGNILKII NNNLGIDEASWMKRIAVYAQPIISKARPDLLRSHFIPTLEKLKKKAIKTVQEEEQLRADS KGDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPDADSDQLFRMVAEIFI LWCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKAMQVKSGGQDQERKKTKRRGDFY SIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYSYKDTDEEVKEHLRNNLHLQEKS DDPAVKWQLNLYKDVLKSGEPSNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHKLLS KQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKSPKVEE EEEEEVEKQPDPLHQIILHFSRNALTERSQLEDDPLYTSYASVMAKSCQSGEDEDEDEDK EKTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGN AGVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRE RGEKVLQNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQES ISDFYWYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAV VGFLHVFANMQMKLSQDSSQIDLLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLV ESSTNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQSEID FLLSCAEADENDMFNYIDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAES VLNYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQE KMELFVNFCEDTIFEMQLASQISESDSADRPDEEEEEGGDSSYVLEVEGEEEEEEKSFEC ASAFAMACGSVKRNVANFLKRATLKNLRKQYRKVKKMTFKELVKVFFSFFWMLFVGLFHL LFTIVGGIIQVLWSTVFGGGLIEGAKNIRVTKILGDMPDPTQFGIHDDAMEAERAEVPEP GIATELVHFVKGQKGDADIMSDLFGLHPKKEGGLKHGPEVGLGDLSEIIGKDEPPTLEST VRKKRKAQAAEMKAAHEAERKIESEKADVEDGEKEDTAKEEEQAEALWADVTKRKKRRCG QKVEKPEAFMANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPL EEETEDVANLWNSFNDEEEEEAVVFFVLQESTGYMAPTLRALAIIHTIISLVCVVGYYCL KVPLVVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKV INKYGDLYGAERIAELLGLDKNALDFSPVEETKAEAASLVSWLSSIDMKYHVWKLGVVFT DNSFLYLAWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLA VVVYLYTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPA GDPYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGN DYFDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAG DCFRKQYEDQLG NT seq 14619 nt NT seq  +upstreamnt  +downstreamnt atggccgaagggggagaaggaggcgaggacgagatccagtttctgcggactgaagatgaa gtggtcctccagtgcatcgccaacgttcacaaggagcagaggaagttctgcctggcagcc gagggactcgggaatcgcctgtgcttcttggaacccacttcagaagccaagtatgttcct ccagatctctgcgtctgcaactttgtgctggaacagtccctctctgtcagagccctgcag gaaatgcttgccaacacaggtgaaaatggcggcgaaggggcagcacaagggggtggccac aggaccctgctgtatggccacgcaattctcctgcggcactccttcagtggcatgtatcta acatgtttgaccacatcaagatcccagacggataaacttgcctttgatgtaggtctacgg gaacatgccacaggagaagcctgttggtggaccattcatcccgcttccaagcagaggtct gagggagaaaaggttcgaattggtgatgacctcatcctcgtcagtgtgtcctcggagaga taccttcatctctcaatatcaaatggtaacatacaagtggatgcctcctttatgcagaca ctctggaatgtacatcctacgtgctcaggaagtagcatcgaagaaggatacctacttggt gggcatgtagtacgtcttttccatggtcacgatgagtgtttgacgataccatctacagac cagaatgattcccagcacagaaggatatactatgaagccgggggagctggcacgagagct agatcgctatggagagtggaaccccttcggataagctggagtggcagtaacatcagatgg ggacaggctttccgactccggcatctcaccacaggccactacctggccttgacagaagac caaggccttatactgcaagaccggggaaagtcggacaccaagtccacggccttctctttt cgagcatccaaggaaatcaaggagaaattggattccagtcacaagcgagatatagaaggc atgggagtcccagaaatcaagtatggagactctgtctgctttgtccaacatatagccagt ggtctgtgggtgacctacaaagcacaagatgccaagacatcccgcctgggacctctgaaa agaaaggtcatactccatcaggaaggccacatggatgatggattaaccctgcagagatgc cagcgtgaggagtcccaggctgctcggatcatccggaacacgaccgccttattcagccag tttgtaagtggaaacagtcgcacagctgccccggtcaccctgccaatagaagaggtcctg cagaccttacatgacctgattgcctacttccagcccccggaggaggggatgcagcatgaa ggcaagcagaacaagctccgctcactcaaaaacagacagaatcttttcaaggaagaggga atgttagcccttgtgttaaactgcattgatcgcttaaatatctacaatagcatagcacac tttgcagggatcgccagggaggagagtggaatggcctggaaagaaattctgaaccttctc tacaaattgctcgctgctcttattcgtggaaacagaaacaactgtgctcaattctccaat aaccttgattggctgatcagcaaattggacagactagaatcttcctcaggtatcttggaa gttttgcactgcatcctcattgaaagcccagaagccttaaacctgatagcagagggccac atcaagtccatcatctccctgttggataagcacggacggaatcacaaggttctggatgtg ctgtgttccctctgtctctgcgatggggtcgcagtgagagccaaccagaatctcatctgt gacaacttgctgccccggagaaacctgctcctgcagacgcggctgattaatgacgtaaca agtattcggccaaacatcttcctgggagttgctgaaggctcagcacagtacaagaagtgg tacttcgagcttatcatcgaccaggtggaccccttcctcacagcagagcccacgcatctg cgggtgggctgggcctcttcctctggctacgctccttaccctggaggcggagaaggatgg gggggcaatggtgttggtgatgacctatactcctatggctttgatggacttcacctttgg tcaggtcgcatacccagagccgtggcctccatcaaccagcacctcctgaagtcagacgac gtggtaagctgttgcctggacctgggggcacccagcatctctttccgcatcaacgggcag cctgtgcaggggatgtttgagaacttcaacacagatgggctcttcttccctgtggtgagc ttttcagcaggtgtcaaagtccgtttcctgctgggtggacgtcatggagaatttaagttc ctgcctccctctggctatgccccttgctatgaagccttacttccaaaagaaaagatgaga ttggagcctgtcaaagagtataaacgtgatgctgaaggaattcgagatctgttgggtacc acccagttcctctcccaagcatctttcatcccatgccccatagataccagtcaggttgtt ttaccacctcatctagagaaaatacgagacaggctggctgaaaacatccacgagctttgg ggaatgaataaaatagagcttggctggacttttggcaagatacgggatgacaataaaaga caacacccctgccttgttgagttttcaaagctgcccgaaactgagaagaattataaccta caaatgtcaactgaaaccttaaaaactctcctggccctggggtgccacattgctcatgtt aacccagctgctgaggacgaactcaagaaggtcaaattgcccaaaaactacatgatgtcc aatggctataagccagcccctttggatttgtctgatgtgaagctgttacctcctcaagaa gttttagtggataagcttgcagaaaatgcacacaatgtctgggcaaaagacagaataaaa caaggatggacctatggcattcaacaggatttaaagaacaaaagaaatccacgtttggtg ccatattcgttgctggatgagcgtaccaagaagtcaaacagggacagccttcgtgaagct gtccggacgtttgttggttatggctataacattgagccatcagaccaagagctagctgac ccagctgtggagaaagtcagcatagacaagatccgctttttccgggtagagcgctcttat gccgtgagatctggaaagtggtatttcgagttcgaggtggtgaccggaggcgacatgcgt gttggctgggcccggccaggctgccgacccgacattgagctgggggcagatgaccaagcc ttcgtgtttgaaggcagcaggggccagcgttggcatcaagggagtgggtattttggacgg acctggcagccaggagatgtggttggatgtatgattaacctggatgatgcttcaatgatc ttcacgctgaatggggagctgctgatcaccaacaaaggctctgaacttgccttcgctgac tacgagattgacaatggctttgtgcccatctgctctctggggctgtctcagatcggccgc atgaatctcgggatggacgccagcaccttcaagttttataccatgtgcggcctccaagag ggctttgagccttttgctgtcaacatgaatcgtgacgtggccatgtggttcagcaaacgc ctcccaacatttgtcaacgtgcccaaggatcatccgcagatagaggtcgtgaggatcgac ggcaccatggatacccctccgtgcctcaaggtgacccacaagacattcggcacccagaac agcagtgccaccatgatctactgccgcctgagcgtgcccgtcgagtgccactcctccttc agtcacagcccctgtatggacagtgatgctttccagaaaaggaaacagatgcaagaaata ctctctcacacaacaacacagtgctactatgcgatccgcatctttgccggacaggacccc tcctgcgtgtgggtcggatgggtgactccggattatcacttgtacagtgaaaagtttgac ctgaataaaaactgtactgtgactgttactctgggggatgaaagaggccgagtccacgaa agcgtgaaacgcagcaattgctacatggtctggggtggggacatcgtggctacatcccaa agagcgagtcgcagcaacgtggacctggagattggctgcctcgtgaatctggcgatgggc atgttgtccttttcagccaacgggagggaacttggcacctgctaccaggtggagcccaat accaaagtgtttccagccgtcttcctgcagcccacaagcacctctctgtttcaatttgaa cttgggaagctgaagaatgccatgcccctgtcagcagccatatttaagagtgaagagaag aaccccgtccctcaatgcccaccacggctggatgtccaaaccatccagcctgtgctctgg agccgcatgcccagcagcttcctgaaggtggagacggagagggtgagcgagcgccatggc tgggtggtgcagtgcctggagcccctgcagatgatggcactccacatcccggaagagaac aggtgtgtggatatcctggagctctgtgagcaggaggacctcatgcggttccattaccat actctgagactctacagcgccttgtgcgccctgggaaatagccgcgtggcctacgccctg tgcagccatgtggacctctcccaactcttctatgccattgacaacaagtacctccctggc ctcctgcgctcaggcttctatgacctgctcatcagcatccacctggccagcgctaaggag aggaagctgatgatgaagaatgagtacatcatccccatcaccagcaccaccaggaaaatc cgcctgtaccccgatgagtccaagaggcacgggctccctggagtgggcccgagaacgtgc ctcaagccagggttcaggttctccaccccctgcttcatcaccaccaacgaggagcaccag aagcagagccccgagattcccttggagcttctcaagatgaaggcactgggcatgctgacg gaggcagtgcagtgcagcggtgctcacatccgggaccctgtcgggggttccgtggaattc cagtttgtgcctgtgctgaagctcatcggaaccctgctgatcatgggggtgtttgatgat gatgacgttcggcagatcctcctcctcatcgacccctctgtgtttggggagcacagtggg gagacggaggagggagcagagaaggaggaggtgacacaggtggaggagaaggctgtggag gctggggaaaaggccagcagggaggctcccatcaaaggcttgttgcagacccgattaccg gagtccgtcaagctgcagatgtgtgagctgctcagctatctctgtgactgtgagctgcag caccgggtggaggccattgtggccttcggtgacatctatgtctccaagctccaggaaaat cagaagttccgctacaacgagctcatgcaggccctgaacatgtctgcggccctgaccgcc cggaagaccagggagttccgctcgcccccacaggaacagatcaacatgcttcttaacttt caactgggggagaactgcccatgcccagaagagatccgggaagagctgtacgacttccat gaggaccttctccttcactgcggggttcccctggaagaagaggaagaggaggaagaggat tcctcctggactggaaaattctgtgccttggtgcagagaatcaaaggccctcccaagcca gagaaggaacaaccaacggaggaagaagagagatgccctacgaccctgaaggagctcatc tcacagaccatgatccgatgggcccaggaggaccagatccaggatgcagagctggtccgg atgatgttcaaccttctgcggcggcagtacgacagcatcggggagctgctgcaggcactg cgcaagacctataccatcagccaggcctccgtgagcgacaccatcagcctgctagctgcc ctgggccaaattcgctgcctgctcagcgtcaggatgggcaaggaggaggagctactcatg atcaacgggctgggagacataatgaacaacaaggtattttaccagcaccccaacctcatg agagtcctcggcatgcatgagaccgtcatggaggtgatggtgaacgtgctgggtgcagaa aagttgcagattgcctttccaaagatggttgctagctgttgccgcttcctgtgctatttc tgtcgaatcagccgacaaaatcagaaggccatgtttgagcatctaagttacctgttggag aacagcagtgttggcctagcttccccctccatgagaggatccaccccactggatgtggcc gcttcctctgtgatggacaacaatgagttagcgctgggcttagaggagccagacctcgag aaggtggtgacctacttggcaggctgtggcctacagagctgccccatgcttctagccaaa ggataccctgatgtcggctggaaccccattgaaggggagcgctacctgtccttcctgagg tttgccgtcttcgtgaacagtgaaagtgtggaagaaaatgctagtgtcgtggtcaagctg ctcatcagacgccccgagtgcttcggccccgccctgcggggtgaaggaggaaacggtctg ttggcggccatgcaaggcgccattaagatctctgagaacccagccctcgacctcccctca cagggctacaagagggaagtcagcacagaggacgatgaagatgaagaagagatcgtgcac atgggcaatgcaatcatgtcattttattcggctcttatagacctgctgggccgctgtgct cctgagatgcaccttatccagacagggaagggagaagccatccggatcaggtccatcctg cgctccctggttcccaccgaggacttggttggaatcatcagcatccccttgaaactgcct tccctgaacaaagatgggtcggtcagtgagccagatatggcagccaacttctgccctgac cacaaggcgcccatggtactgttcttggaccgtgtgtatggcatcaaggatcaaactttt ctgctccacttgctggaagttggatttttacctgacttaagagcctctgcctctctagat acagtttccctaagcaccaccgaggctgcactggcactgaacaggtacatatgttctgct gtgctcccactcctcacaagatgcgcccctctctttgccgggacagagcactacacttct ttgattgactctacactgcagacaatatacaggctttccaaggggcgatccctcaccaaa gctcagagggacaccatagaggagtgtttgctggccatttgcaatcacttgaggccttcc atgttacagcaactcctgcgacgtctagtttttgatgtgccccaactcaatgaatactgc aaaatgcctcttaagcttctgacgaatcactacgaacagtgctggaagtactattgtctg ccttcgggctgggggagctacggtctggccgtggaggaagagctacatctgacagagaag ctcttctgggggatttttgactccctctctcataagaggtatgacccagatctcttccgg atggccctgccctgtctcagtgcaatagcgggggccctgccaccagattatttagatacc agaatctcagccacattggagaaacaggtctcagtggacgcagatggcaactttgacccc aaacctatcaacactgtgaatttctccttgcctgaaaaattggaatacattgtcaccaag tatgctgagcactcccatgatagatgggcctgtgacaagagtcagaatggatggaaatac ggaatttcgctggatgaaaatgtgaagacccatccattgatccggcctttcaagacatta accgagaaggagaaggaaatttatcgctggcctgccagagagtccctgaaaaccatgctg gctgtgggctggactgtagagaggaccaaagagggagaagctctggttcaacagcgggaa aatgagaagcttcgaagcgtgtcccaggccagccagggcaacagctacagccctgcccct ctggatctctccaatgtcgtgctctccagagagctccaggggatggtggaggtggtagct gagaactatcacaatatctgggccaagaagaagaagctggagctggagagcaaaggtggt ggcagtcaccctcttttggtaccctatgataccttgactgccaaggaaaagttcagagac cgagagaaggcccaggacctgtttaaattcctccaagtgaatggcattgtggtttccaga ggtatgaaggatatggagctggatgcctcctccatggaaaagaggtttgcctataagttt ttgaagaaggttctgaaatatgttgattcggctcaagagtttattgcccatttggaagcc attgtcagcagtgggaaaaatgaaaagtctccccatgaccaggagatcaaattctttgcc aaagttctcctcccactggttgaccagtacttcatcagtcatcgcctgtacttcctgtcc tcccctctgaagccccttagcagcagcgggtatgcctcccataaggagaaagaaatggtg gccagcctgttctgcaaactcgctgctctggttcgacacaggatttccctcttcgggagc gattctacgacaatggtgagctgtcttcacatcttagctcagacacttgacacaaggacg gtcatgaagtcaggctcagagctggtgaaagccgggttacgggcattctttgaaaatgca gcggaagacttagagaaaactttggaaaacctgaagctcggcaagtttacccattccaga acacagatcaaaggcgtctctcaaaatattaactacaccacggtggctctgctccccatc ttgacatccatctttgagcacgtggctcagcatcagttcggggtggacttactcttgggt gatgtgcagctttcatgctaccatatactgtgcagcctctactccctcgggacaggaaag aacatctatgttgaaaggcagcgtcctgcccttggagaatgcctggcctcactggcagcc gccataccagtggcattcctggagcccacccttaaccgctacaacccgctctccgtcttc aacaccaaaacccccagggagaggtctattctggggatgccagacacagtggaggagatg tgccccgacatcccccagctggaaggcctgatgaaggaaatcaacgacctggccgagtca ggggcccggtacacagagatgccccacgtcattgaggtcatcttgcccatgctctgcaac tacctgtcctactggtgggagcgggggcccgagcacctgccccccagtgcagggccctgg tgcaccaaggtcacgtctgaacacctcagtgtcatcctgggcaacattctgaaaatcatc aacaacaacctgggcatcgacgaggcctcttggatgaagcgcattgcagtgtacgcccaa ccgatcatcagcaaagccaggccagacctgctgagaagccacttcatcccgaccctggag aagctgaagaagaaggccatcaaaactgtgcaggaggaggagcagctgagagctgacagc aagggcgacacgcaggaggctgagctgctcatcctggacgagtttgctgtcctctgcaga gacctctatgccttctaccctatgctcatccgctacgtggacaacaacagatctaactgg ctcaaaagcccggatgcagactctgaccagctcttccgcatggtggcagagatcttcatc ctgtggtgtaaatctcacaacttcaagagggaagagcaaaattttgtgattcagaacgaa attaataatttggcatttttaactggagacagcaaaagcaagatgtcaaaagccatgcaa gtaaagtctggaggacaggaccaggagcggaagaagacaaagcgaaggggagacttttat tccatccagacctccctcatcgtggctgcgctcaagaaaatgctgcccattggtctgaat atgtgcaccccaggcgatcaggagctgatctccctcgcaaaatcacggtacagctataag gacacagatgaagaggtgaaggaacatctgcggaataacttgcacttgcaggaaaagtct gatgatccagctgtaaagtggcaactgaacctatacaaagatgttttaaagagtggagaa ccttccaacccagaaaagacagtggagcgtgtgcagagaatttcagcagctgtcttccac ctagagcaggtggaacagcctttgaggtccaagaaggcggtctggcacaaactgctatca aagcagcggaaacgggcagtggtggcctgtttcaggatggcccctctctacaacttgccc aggcaccgctctattaacctcttcctccatggctatcagagattttggatagaaacagag gagtattcctttgaagagaaactagtacaggatttggctaaatctcccaaggtggaagag gaggaggaggaagaggtggaaaagcagccagacccgcttcatcagatcatcctccacttt agccgcaacgctctcacggagaggagccaactggaagacgaccctttgtacacctcctat gccagcgtgatggccaagagttgtcagagtggggaagacgaagacgaggacgaagacaag gagaaaacatttgaagagaaagaaatggagaagcagaaaaccctctatcagcaagcccgg ctgcatgagcgtggagctgccgagatggtccttcagatgatcagcgccagcaaaggtgag atgagccccatggtggtggagactctgaagttggggatcgccattctgaatgggggcaat gccggtgtgcagcagaaaatgctagattacctaaaggaaaaaaaggatgctgggttcttt caaagtctttctggtcttatgcagtcttgcagtgtccttgatttgaacgcatttgagagg cagaataaagctgaaggcctggggatggttactgaggaaggaacactcattgttcgtgag cgtggtgaaaaagtactccagaatgacgagtttacacgagatctctttagattcctgcag ttactttgtgaaggacacaacagtgatttccagaacttcctgaggactcagatgggcaac accaccacggtgaacgtcatcatcagtaccgtggactaccttctgcgtctgcaggaatca atcagtgatttctactggtattactcagggaaggacatcattgatgaatctggacagcac aatttttccaaagccctggcggtcaccaagcagatcttcaattctcttacagaatacatc cagggcccctgcattgggaaccagcagagcctggctcacagcaggctgtgggacgcggtg gtcggcttcctccatgtgtttgctaacatgcagatgaaactctcccaggattccagtcag atcgacctgctgaaggaactcttggatctccttcaggacatggtggtgatgcttctgtcc ctcctggaagggaatgtggttaatggaaccattggcaagcagatggttgacacactggta gaatcatctaccaatgtagaaatgatcttgaaattctttgacatgttcttgaaacttaaa gacttaaccagctcagataccttcaaagaatatgaccccgatgggaaaggaatcatttcc aaaaaggaattccagaaggccatggaagggcaaaagcagtacacacagtcggagatagac tttctcctttcatgcgcagaagctgatgaaaatgacatgtttaattacatcgattttgtt gaccggttccatgagccagccaaggacatagggtttaatgtggcagtgttattgacaaac ctctctgagcacatgccaaacgattctcgccttaagtgtctgttggacccagcagaaagt gtactcaattacttcgaaccatacctgggacgcattgagatcatgggtggggccaagaaa attgagcgtgtttattttgagatcagcgagtccagtcgaactcagtgggagaagccccag gtgaaggagtctaagcgacagttcatctttgacgttgtcaatgaaggtggggagcaagag aagatggagctgttcgtgaacttctgtgaggacaccatctttgagatgcagttagcatcg cagatctcggaatctgactcagccgacaggccagatgaggaggaggaagaaggtggagat tcttcttatgtgttagaagtggagggtgaggaggaggaggaggagaagtcctttgagtgt gcctctgcatttgccatggcttgtggctcagtgaagagaaacgtggccaactttctgaag agggccaccctgaagaacctcaggaagcagtacaggaaggtgaagaagatgaccttcaag gagctggtgaaggtgttcttctctttcttctggatgttgttcgtggggctcttccacttg ctcttcactatagtgggaggaatcattcaggtcctctggagcacagtgttcggaggggga ctcatagaaggggcaaagaacataagagtcaccaagatcctgggtgacatgcctgaccca acccagtttggtatccacgatgatgctatggaagctgagagggcagaagtgcctgagcca ggcatcgccacagaactcgtgcacttcgtaaaggggcagaagggagatgcagacatcatg tcagatctctttggactccacccaaagaaagaaggtggcttaaagcatgggcctgaagtg ggtttgggtgacctctctgagattattggcaaggacgaaccccctaccttagagagtact gtccggaagaaaaggaaagcacaggcagcagaaatgaaagcagctcatgaagcagaaaga aaaatagagtctgagaaggcagacgtggaagatggggagaaagaggacacagccaaagaa gaagagcaggccgaggccctgtgggcagacgtgaccaaaaggaagaagcgacggtgtggc cagaaggttgagaagcctgaagccttcatggccaatttctttaaagggctggaaatctat cagaccaagttgctgcactacctggccaggaatttctacaacctgaggttccttgctctg tttgtagccttcgctatcaacttcatcctgctcttttacaaggtcaccgaagaaccttta gaagaagagacagaggatgttgcaaacctgtggaattcctttaatgatgaggaagaggaa gaggcagtggtgttctttgtcctgcaggagagcactgggtacatggcgccaaccctgcgg gccctggccatcatccacaccatcatctctttagtctgcgtggtgggctactactgccta aaggtccctttggtcgtattcaaaagagaaaaagaaatcgccaggaagctggagtttgat ggcctgtatatcactgaacagccttctgaagatgacatcaaggggcagtgggatcgcttg gtaatcaacacgccatctttccctaataactactgggacaagtttgtaaagagaaaggtg atcaacaaatatggagatctctatggagcagaacgcattgctgaactcctgggtttggac aaaaatgcccttgactttagcccagtggaagagaccaaagcagaggcagcctccctggtg tcatggctaagttccatcgacatgaagtaccatgtctggaagctgggagttgtttttact gacaattcctttctctacctcgcctggtacacgaccatgtcagtcctgggccactacaac aactttttcttcgcggctcatcttctggatatcgcgatgggcttcaagactctgaggact attctgtcctctgtcactcacaatggcaaacagttggtcctgaccgttggtctcctggct gtggtggtttatctctataccgtggtggcattcaacttcttccgcaagttctacaacaaa agtgaagacgacgacgagcccgacatgaagtgtgatgacatgatgacgtgttacctgttc cacatgtacgtgggagtgagagctggaggtggcattggtgatgaaattgaagaccctgct ggggacccgtatgaaatgtatcgcatcgtttttgacattaccttcttcttcttcgtcatt gtcatcctgctagccatcatccaaggtcttattattgatgcttttggggagctgagagac cagcaggaacaagtacgagaggatatggagactaaatgtttcatctgtgggattggcaat gactactttgacacaacgcctcatggttttgaaacacacaccctgcaagagcacaactta gccaactacctgttcttcctcatgtatttgattaacaaagatgagacagagcacacggga caggaatcttatgtctggaagatgtaccaagaaaggtgctgggatttcttcccagctggt gactgcttccggaaacaatacgaagatcagcttggataa

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