Bison bison bison (American bison): 104994776 Help Entry 104994776         CDS       T08726                                  Symbol TLR4 Name (RefSeq) toll-like receptor 4 isoform X1   KO K10160   toll-like receptor 4 Organism bbis  Bison bison bison (American bison) Pathway bbis04064   NF-kappa B signaling pathway bbis04066   HIF-1 signaling pathway bbis04145   Phagosome bbis04151   PI3K-Akt signaling pathway bbis04217   Necroptosis bbis04613   Neutrophil extracellular trap formation bbis04620   Toll-like receptor signaling pathway bbis04621   NOD-like receptor signaling pathway bbis04936   Alcoholic liver disease bbis05132   Salmonella infection bbis05133   Pertussis bbis05134   Legionellosis bbis05135   Yersinia infection bbis05140   Leishmaniasis bbis05142   Chagas disease bbis05144   Malaria bbis05145   Toxoplasmosis bbis05146   Amoebiasis bbis05152   Tuberculosis bbis05161   Hepatitis B bbis05162   Measles bbis05164   Influenza A bbis05170   Human immunodeficiency virus 1 infection bbis05171   Coronavirus disease - COVID-19 bbis05205   Proteoglycans in cancer bbis05235   PD-L1 expression and PD-1 checkpoint pathway in cancer bbis05321   Inflammatory bowel disease bbis05323   Rheumatoid arthritis bbis05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:bbis00001]  09130 Environmental Information Processing   09132 Signal transduction    04064 NF-kappa B signaling pathway     104994776 (TLR4)    04066 HIF-1 signaling pathway     104994776 (TLR4)    04151 PI3K-Akt signaling pathway     104994776 (TLR4)  09140 Cellular Processes   09141 Transport and catabolism    04145 Phagosome     104994776 (TLR4)   09143 Cell growth and death    04217 Necroptosis     104994776 (TLR4)  09150 Organismal Systems   09151 Immune system    04613 Neutrophil extracellular trap formation     104994776 (TLR4)    04620 Toll-like receptor signaling pathway     104994776 (TLR4)    04621 NOD-like receptor signaling pathway     104994776 (TLR4)  09160 Human Diseases   09161 Cancer: overview    05205 Proteoglycans in cancer     104994776 (TLR4)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     104994776 (TLR4)   09172 Infectious disease: viral    05170 Human immunodeficiency virus 1 infection     104994776 (TLR4)    05161 Hepatitis B     104994776 (TLR4)    05171 Coronavirus disease - COVID-19     104994776 (TLR4)    05164 Influenza A     104994776 (TLR4)    05162 Measles     104994776 (TLR4)   09171 Infectious disease: bacterial    05132 Salmonella infection     104994776 (TLR4)    05135 Yersinia infection     104994776 (TLR4)    05133 Pertussis     104994776 (TLR4)    05134 Legionellosis     104994776 (TLR4)    05152 Tuberculosis     104994776 (TLR4)   09174 Infectious disease: parasitic    05146 Amoebiasis     104994776 (TLR4)    05144 Malaria     104994776 (TLR4)    05145 Toxoplasmosis     104994776 (TLR4)    05140 Leishmaniasis     104994776 (TLR4)    05142 Chagas disease     104994776 (TLR4)   09163 Immune disease    05323 Rheumatoid arthritis     104994776 (TLR4)    05321 Inflammatory bowel disease     104994776 (TLR4)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     104994776 (TLR4)   09167 Endocrine and metabolic disease    04936 Alcoholic liver disease     104994776 (TLR4)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:bbis04131]     104994776 (TLR4)   09183 Protein families: signaling and cellular processes    04054 Pattern recognition receptors [BR:bbis04054]     104994776 (TLR4)    04090 CD molecules [BR:bbis04090]     104994776 (TLR4)    00536 Glycosaminoglycan binding proteins [BR:bbis00536]     104994776 (TLR4) Membrane trafficking [BR:bbis04131]  Endocytosis   Phagocytosis    Toll-like receptors     104994776 (TLR4) Pattern recognition receptors [BR:bbis04054]  Membrane-bound pattern recognition receptors   Toll-like receptors    104994776 (TLR4) CD molecules [BR:bbis04090]  Proteins   104994776 (TLR4) Glycosaminoglycan binding proteins [BR:bbis00536]  Hyaluronan   Cell surface receptors    104994776 (TLR4) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  LRR_8 LRR_4 TIR LRR_1 TIR_2 LRR_9 LRR_6 ThsB_TIR Motif Other DBs NCBI-GeneID:  104994776 NCBI-ProteinID:  XP_010846733 Ensembl:  ENSBBBG00000018921 UniProt:  A0A6P3HVW8 LinkDB All DBs Position Unknown AA seq 841 aa AA seqDB search MMARARLAAALIPATAILSCLRTESWDPCVQVVPNISYQCMELNLYKIPDNIPISTKMLD LSFNYLRHLGSHNFSSFPELQVLDLSRCEIKIIEDDTFQGLNHLSTLILTGNPIQSLAWG AFSGLSSLQKLVAVETNLVSLNDFPIGHLKTLKELNVAHNFIHSFKLPEYFSNLPNLEHL DLSNNKIQNIYYEDVKVLHQMPLLNLSLDLSLNPLDFIEPGTFKEIKLNGLTLRSNFNSS HVMKTCIQGLAGLKTNRLVLGEFKNERKLQRFDRSFLEGLCNLTIEQFRIAYLDKFSGDD TDLFNCLANVSVISLLSISLGSLQALLKDFRWQHLEIINCDFDKFPALKLSSLKKFVFTD NKDISTFTEFQLPSLQYLDLKRNHLSFKGCCSHTDFGTTNLKHLDLSFNDVITLGSNFMG LEQLEHLDFQHSTLKQINAFSAFLSLRNLRYLDISYTNIRIVFHGIFTGLVSLQTLKMAG NSFQNNLLPDIFTELTNLTVLDLSKCQLEQVAQTAFHSLSSLQVLNMSHNKLLSLDTFLY EPLHSLRILDCSFNRIMASKEQELQNLPRSLTWLNLTQNAFACVCEHQSFLQWVKDQRQL LVGAEQMMCAEPLDMEDMPVLSFRNATCQLSKTIISVSVVTVLLVSVVGILVYKFYFHLM LLAGCKKYGRGESTYDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIA ANIIQEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKLEKSLL RQQVELYRLLSRNTYLEWEDSVLGRHVFWRRLRKALLAGKPQSPEGTADAETNPQEATTS T NT seq 2526 nt NT seq  +upstreamnt  +downstreamnt atgatggcgcgtgcccgcctggctgcggctctgatcccagccacggccatcctctcctgc ctgagaaccgagagctgggacccttgcgtacaggttgttcctaacattagttaccaatgc atggagctgaatctctacaaaatccccgacaacatccccatatcaaccaagatgctggac ctgagctttaactacctgagacatttaggcagccataacttctccagcttcccagaactg caagtgctggatttatccagatgtgaaattaagattattgaagatgacacatttcagggc ctaaaccacctctccaccttgatactgacgggaaaccctatccagagtttagcctgggga gccttttctgggctatcaagtttacagaagctggtggccgtggagacaaacctagtctct ctaaatgacttccccattggacatctcaaaaccttgaaagagcttaatgtggctcacaat tttatccattccttcaagttacctgaatatttttctaacctgcccaacctggagcacttg gatctttctaacaacaaaatccaaaatatttattatgaagatgtgaaagttctacatcaa atgcccctactcaacctctctttagatttgtccttgaaccctttagactttattgaacca ggtacctttaaagaaattaagctcaatggattgactctgcgaagtaattttaacagttca catgtcatgaaaacctgtattcaaggtctggctggtttaaaaaccaaccggctggttttg ggagaatttaaaaatgaaaggaagttgcaaagatttgacagatctttcctggagggactg tgcaacctgaccattgaacaattccggatagcgtacttggacaaattctcaggggacgat acagacttatttaattgtttggcaaatgtttccgtgatttctctgttgagtatatcttta ggaagtctacaagcccttcttaaagattttagatggcaacacttagaaattattaactgt gactttgacaagtttcctgcattgaagctcagttctctcaaaaagtttgttttcacagac aacaaagatataagcacttttactgagtttcagctaccgagccttcagtatctagatctc aaaagaaatcacttgagtttcaagggttgctgttctcacactgattttgggacaaccaac ctgaagcatttagatctgagcttcaatgatgtcattaccttaggttcaaacttcatgggc ttagagcaactagaacacctggattttcagcattccactctgaaacagatcaatgctttt tcagcattcctatcactcagaaacctccgctaccttgatatttcttataccaacatccgc attgtcttccatggcatctttactggcttagtcagtctgcaaaccttgaaaatggcaggc aactcttttcagaacaacttgctccctgacatcttcacagaactgactaacttaaccgtc ttggacctctctaagtgtcaactggaacaggtagcccagacagcatttcactccctctct agccttcaggtgctgaatatgagtcacaacaaactcttgtcattggatacatttctttat gaaccactccactcgctccggatcctagactgcagtttcaaccgtatcatggcctctaag gagcaagaactacagaatttgccaaggagcctcacttggctaaatcttactcagaatgca tttgcttgtgtttgtgaacatcagagtttcctgcagtgggtcaaggaccagaggcagctc ttggtgggagctgagcaaatgatgtgtgcagagcctttagatatggaggacatgccagtg cttagtttcaggaatgccacttgtcagctgagcaagacgatcatcagtgtgtcggtggtc actgtgctcctggtgtctgtggtaggaatcctagtctacaagttctatttccacctgatg cttcttgctggctgcaaaaagtatggcaggggcgagagcacctatgatgcctttgtcatc tactcgagccaggatgaagactgggtgcggaatgaactggtaaagaacttggaggagggc gtgcccccctttcagctctgccttcactacagggactttattcctggggtggccatcgcc gccaatatcatccaggagggtttccacaaaagccgtaaggttattgtcgtggtgtcccag cacttcatccagagccgatggtgtatcttcgagtatgagattgcccagacctggcagttt ctgagcagccgtgctggcatcatcttcatcgtcctgcagaagctggagaagtctctcctg cggcagcaggtggagctctatcgccttctgagcaggaacacctacctggagtgggaggac agtgtcctggggcggcatgtcttctggagaagactcagaaaagccttgctggctggtaaa ccccagagtccagaaggaacagcagatgcagaaaccaacccgcaagaagcgacaacctcc acctga

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