KEGG T08726: 104995523

Bison bison bison (American bison): 104995523

Entry

104995523         CDS       T08726

Symbol

LRP2

Name

(RefSeq) low-density lipoprotein receptor-related protein 2

K06233

low density lipoprotein-related protein 2

Organism

bbis Bison bison bison (American bison)

Pathway

bbis04340

Hedgehog signaling pathway

bbis04918

Thyroid hormone synthesis

bbis04979

Cholesterol metabolism

Brite

KEGG Orthology (KO) [BR:bbis00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04340 Hedgehog signaling pathway
    104995523 (LRP2)
09150 Organismal Systems
  09152 Endocrine system
   04918 Thyroid hormone synthesis
    104995523 (LRP2)
  09154 Digestive system
   04979 Cholesterol metabolism
    104995523 (LRP2)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:bbis04131]
    104995523 (LRP2)
Membrane trafficking [BR:bbis04131]
Endocytosis
  Clathrin-mediated endocytosis
   Low-density lipoprotein receptor (LDLR) family proteins
    104995523 (LRP2)

SSDB

Motif

Pfam:

Ldl_recept_a Ldl_recept_b FXa_inhibition cEGF EGF_LRP2 SGL EGF_CA Vgb_lyase

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

Ensembl:

UniProt:

LinkDB

Position

Unknown

AA seq 4702 aa
MGLVCAAGVLRARMEKVSAMKRCKLLSSCRESFSFLQERRRGKEEEGMKKYDDIVNALIL
GNTCVDNFLNWLSLACGITGCRSNEFLCQPGLCITASWRCDGTRDCPNGADEIDCPTSSC
HSNQFLCPNEQLCIPESWVCDGEDDCNDGADERRHCPGITCSSHQFTCENGECIPGEFRC
DHSTDCLDGTDEKNCRYPVCEQLTCADGACYNTSQRCNGQVDCRDASDERNCTHRCTRTE
FQCGSGQCIPRTYVCDHEIDCEDGSDEHSCPAYRTCKGNEFTCPNGVCIAQSWVCDGESD
CVDNADEDGCESKINRTFECYPNEWACPKSGKCIPISKVCDGTLDCPGGEDESNITAGQQ
CDVNLCPSLGCEYQCHRSPGGGMCYCPSGFIVNQNRTNNCVDFDDCQIWGVCDQLCEDRI
GHHRCNCVEGYVLERQKHCRANSSFGEAFVIFSNGRNLLKGSIRGNNFQILAESQNRGLA
VGVDFHYRLRRVFWTDIVQKKVFSVDISGSRIREVLGVSIEDPENLAVDWVNNKLYIVET
RVNCIDVVDLDGSHRITLISEYLGHPRGIAVDPTVGYLFFSDWQNVFGVPRIERAYMDGS
NRKDLVTTKLGWPGGITLDLVSKRVYWVDSRFDYIETVTYDGLKRMTVIHGGADIPHPFS
ISLFEGQLFFTDWTKMAVLKANKFKETNPRLYYRSSLKPFGVTVYHGLRQPYARNPCAHE
NGGCQHICVLSHRTFNGGLGYRCKCRLGYIPDWDDYHCVAAERFLLFSSNLAVRGIPLTL
SHQTEVILPVTGSSSIFLGIDFDAREKAIFFSDTKKNIIYRQKLDGTGREIITANRVPAV
QSLSFDWISRNLYWTDSSYRSVSVIRLADKSRRTIIQNLNNPQSIVVHPTAGYIFFSVWY
RPAKILRAWADGSNILPIVNTTLGWPSGLSIDWSSSRLYWVDAFFDKIEHSNFDGSDRKA
LTNVHQLTHPFGLAVSQDYIYVTDWRRGIIRFGKYNPGQSIILRSGVGSVMRAKVYDSRV
QTGSNACSRPTNPNGDCSHFCFPVPNSQRVCGCPYGMSLASDHLTCVENASREPPVEQCG
TLSFSCHNGRCVPLQYRCDGFDDCLDNSDEAQCTTSNATCSPLAFECKREGHCIPSMWRC
DGEDDCLDGSDEQNCPTRAPTSCRADQFTCDNNFCIPRSWVCDTDNDCKDGSDEKSCNYT
QTCSPTQFHCPDHRCIALTFVCDGTKDCADGSDEIGCVINCTASQFTCVSNGQCISKTYR
CDGVFDCDDHSDETDCPTRPPGMCHQDEFQCQEDGICIPKTWECDGHEDCLQGSDEHNGC
PPKTCHPSHFVCQNGNCIYRNWLCDGDNDCGDMSDEKDCPTQPFQCPSWQWQCPGHSICV
NLSAVCDGVSDCPGGTDESPLCNQNSCSDSNGGCTHQCIQGPYGAQCQCPLGYLLGNDSK
TCEDIDECHTPGFCSQYCYNMRGSFRCWCDSEYTLDADRRTCKATESETLLLVASQSQLV
AGNMTQNGYFVYPVIQHGSHIVAVDFDSVSDRIFWSDGTQGKIWSAFQNGTDKKLILDSG
VSMTGSIAVDWIGRNLYWTDISLRTIDVAKLDGSHKTVLISENITNLGGLAVDPRATDRV
MFWSDWGSHPRIERASMDGSQRTIIVQEKIYWPNGLALDYPNRLLYFMDGYLDYLDFCHY
DGSNRRQVIASDLILRHPYSISLFEDTVYWSDRATHEVMKANKWHGGNQSVVMTLHQPLG
IVVVHPAKQPVSSNPCSYTRCSHLCLLSSKSLYSCACPSGWTLARDSVTCVRDDQAFLIV
VRNSIIFGISLNPDVKTFDGMVPISGIRNGYDVAVDYSEQFIYWLENPGEIHRVKTDGTN
RTVFAPLSSLGASASLALDWLSRNLYFTDHVTRSIKVMTLRGDVSYRKTLIANDGTSLGV
GLPVGITIDPISGKLYWSDRGTNSGLPPKIASANMDGKSPRTLFTGSLENVAFITLDIEE
QKLYWAVSSTGVIERGNVDGTNRMILVNHLSYPWGLAVHGPFLYYSDEEYEVIERVDKAT
GANKVVLRNNLPDLRGLKIYQRRGSESSNGCSNNMNACQQICLPVPGRLFSCACATGFKL
NPDHQTCSPYNSFIVVSTLRTIRGFSLQLSDHSEAMVPVAGPGRNALHVDVDVSSGFIYW
CDFNVSVASNNAIRRIKPDGSNFTNIVTDGIGVNGVRGIAVDWVAGNLYFTNAFRSETLI
EVLRINTTHRHILLKTIVDMPRDIVVDPKNRYLFWSDYGQNPKIERSFLDCTSRTVLVSD
ITATPRGLALDHSSNYIYWVDDAVDLIARISIEGGETEVIRFGSHYPAPYAITVFGNSII
WVDRNLKKILQASKEPNRADRPTVIRDNIDWLRDVTIFDQSVQPRSPAEVNNNPCLENNG
GCAQFCFALPKSQTPKCDCAFGTLQADGRSCAISSENFLIFALDDSLRSLRFDPKDYSQP
FPAISVERMAVALDYDSIDNRIYFTQLLPSGKGQISYINLNSRSSPPTVVVSGIGSPEGI
AFDWINKRIYYSDYTNQMIKSIATDGSRHTLIAQVPKPRGIVLDPCQGYMYWTDWGTNAK
IEMATMGGYSRRSLVDRGLVWPNGLTLDYEQNLIYWADANLEKIERMDLEHYLREVIVSR
ANSPFGLAIYGQYVYWTDLLTQKIYRANKVDGSGQTAVTVTLPFRPKGIRAVVKDQQQCL
SPCDRFNGGCSHICAPGPNGAECQCPHEGRWYLANNNKYCIQDNGTRCDSSKFTCLSGKC
IPDQLQCNDIDDCGDSSDELETLCAFHSCPSTSFTCANGRCVPYSDRCDHYNDCGDNSDE
AGCHFRACNRTEFTCSNGRCIPSELVCDGVDNCLDNSASDEKNCPERTCHPGYVKCTNST
ICIPRSFLCDGDNDCGDMSDENPLFCATRSCGSDEFHCTSGPCIPARWYCDHEKDCSDGS
DEPPTCEFSQSTCASDYFKCDNNRCIPMMWVCDGDNDCGDMSDEDERHNCTSENRNCSSS
EFACEVGVRPHRGCIPKSWVCDGEADCLDALDEHQNCTRRSCFGTEFVCNNGLCIPNHFR
CDRNNDCGDYSDERGCVYPTCDETLFTCQNGLCINKAYVCDGDNDCKDNSDELEHLCHTP
ETTCPPHQFRCDNGNCIEMMKVCNNFPDCSDNSDEKGCGINECNDPTLSGCNQNCTDTLT
SFYCSCNPGYKLLSDKRTCVDIDECEETPFVCSQKCENLPGTYICKCAPGYIREPDGKTC
RQNSNIEPDLIFSNRYYLRNLTVYGHLYSLILQGLGNVVALDFDRVEKRLYWLDIENKVI
ERMFVNTTNRETVLKHNLPGAESLAVDWVTRKLYWVDSYLNCLSVSDLNGRYRRKLAEHC
VDANNTFCFENPRGLALHPRYGHVYWADWGDRAYIGRVGMDGTLKSLIISTKIMWPNGLT
IDYTNDLLYWADAHLGYIEYSDLEGRHRHTVYETGTLSHPFAITIFEDTIYWTDWNTKTV
EKGNKYNGSDRVALLNVTHRPYDIHVYHPYRQPIVPNPCGTNNGGCSHLCLIKEGGVGFT
CECPDNFYTVQHGPNTQCLPMCSSTQFLCADSEMCIPIWWKCDGRRDCLDGSDEPITCPQ
RFCALGMFQCNDGNCTNSHSLCNLRQDCPDGSDEDPVLCEHHQCEPYEWQCANKRCIPES
WQCDMQDDCDDNSDEDSSHCASRTCRPGYFKCANGHCIPQIWKCDVDNDCGDYSDEPLQE
CLGPSYRCDNYTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQDCESMTCKPSGEFRCTNH
RCIPLRWRCDGQNDCGDRSDEENCAPRKCTESEFRCDDQSCIPSRWVCDQTNDCGDNSDE
RDCEMMTCRPGYFQCDSGHCISEHMKCNGVADCRDASDEANCPTRFPNGAYCPATMFECK
NHVCIHSSWKCDGDNDCGDGSDEELHLCLNVACDSPYRFRCDNNRCIYRHEVCNQEDDCG
DGSDEKKELCVEPTPRPCTPDEFKCSNGRCIPQHRVCDHVNDCGDNFDETGCNTGKDRSC
AENLCEHNCTQLREGGFICSCRPGFKPNSIDRNLCEDINECMQFGSCPQICHNTKGSYEC
SCAEGFTSLSDRYGERCAADGSPPLLLLPENVRIRKYNLSSLQFSEYLEDQERIKAMDYD
WDPEGTGLSVVYYTVLGEGSNSGAIKRAYIPNFESGSNNPVMEINLDLKYIVQPDGLAVD
WVGRHIYWSDARRQRIEVAELDGRYRKWLISTELGQPAAIVVNPKLGFMYWTDWGENPKI
ESAWMDGQRRKVLVQEDLGWPTGLCIDYMNGDRIYWSDLKDNIVETIKYDGTDRRIVVTS
AVNPYSLDIFESQLYWTSKDKGEVWIQDKFGRNKKEKLLTVNPWLTQVRVFHQRKYNHSV
PNRCKDVCSHLCLLRPKGYTCACPQGSRFLEGSVTVCDAAIVGAVSMPPPCRCMNRGSCY
FDENNLPKCKCSSGYVGEYCEMGLSQGVPPGTTASVLLTVILIVIIAALATLGFLHYRKT
GSILPSLPKLSSLSHLKSSENGNGVTFRSGDDVNMDIGVTGFGPESAIDRSLAMNEHFAA
DFGKSPIIFENPTYSSKDTAITVAQPTTAPVTESATVYNKNYGSPINPAELVTDTKPTSS
SDETQPTKWNIFKRKPKQNTNFENPFYSEMENEPKVGAAVTPPPSPSPPAKVSWKKGSTP
GYSATEDTFKDTANLVREDSEA

NT seq 14109 nt +upstreamnt +downstreamnt
atggggctcgtctgcgctgccggagttttgagggctcgaatggagaaagtttctgcgatg
aagcgctgtaaacttctctcaagttgtcgggagagttttagttttttacaggaacggagg
cgagggaaagaggaggagggaatgaagaagtatgatgacattgtaaatgcccttatttta
ggaaatacctgtgtggataactttttaaactggctttctcttgcttgtgggattacagga
tgtcgcagtaatgagtttctgtgccaacctgggctgtgtattactgcgtcttggcggtgt
gatgggacccgagactgcccaaatggcgcggatgaaattgactgccccaccagtagttgc
cattccaaccagttcctgtgtccgaatgaacagctctgcatccctgagagctgggtgtgt
gatggggaagatgactgcaatgatggtgcagatgaacgtcggcattgccctggaataaca
tgctccagccatcagtttacatgcgagaatggcgaatgtatcccaggggagttcagatgc
gaccattccacagactgcttagatggaaccgatgagaaaaactgccgatacccagtatgt
gagcagctaacttgtgccgacggagcctgctataacaccagtcagaggtgtaatgggcag
gttgattgcagagatgcctctgatgaacgcaactgcactcaccggtgcacgcgcactgag
tttcagtgtggcagtgggcagtgcattcctagaacctacgtctgtgaccatgaaattgac
tgtgaagatggcagtgatgaacattcttgccctgcttatcggacctgcaaaggcaacgaa
ttcacttgccctaacggcgtctgcattgcacagagttgggtttgtgatggagaaagtgac
tgtgtagataacgctgatgaagatggatgcgaaagcaaaattaatcgtacctttgaatgt
tacccaaatgaatgggcctgtccaaagtctggaaaatgcatcccaatttctaaagtttgt
gatgggactttagattgtccaggaggagaagacgaaagcaatatcactgcaggacaacag
tgtgatgtgaatctgtgtccgtccttgggatgtgaataccaatgccacaggtcaccaggt
ggagggatgtgttactgcccctcaggttttattgtcaaccaaaatagaaccaataactgc
gtcgattttgacgattgccagatatggggagtttgtgaccagctatgtgaagaccgaatt
ggccatcaccggtgtaactgtgtagaggggtatgtcttggagcgccagaagcactgcaga
gctaattcttcttttggtgaggcctttgtgatcttctccaatggtcggaatttgctaaag
ggtagcattcgtggaaacaactttcagattctggcagagtctcaaaatcgtggattggct
gtgggtgtggattttcactatcggctacgcagagtcttttggacagacattgtgcaaaag
aaggttttttcagttgacatctctggttcacgtatcagagaagttctcggtgtttctatt
gaagacccagagaatctggctgtggattgggtaaataataaactttatattgtggagacc
agagtcaactgcatagatgtggtagatttggatggaagccatcggattacccttataagt
gaatatttgggacatcctagaggaattgctgtggacccaactgttggttatttatttttc
tcagattggcagaatgtttttggagtaccgaggatagaaagagcttacatggatggctcc
aaccgaaaagacttggtaacaacaaagctgggatggcctggtgggataaccctggatttg
gtatcaaagcgtgtttactgggttgactcccgatttgattacattgagactgtaacttat
gatggacttaaaaggatgacagtaattcatggaggcgcggacattcctcatcccttttca
ataagcttgtttgaaggacagttgttcttcaccgattggacaaagatggctgtattgaag
gcaaacaagttcaaggagactaaccccagattgtactaccgctcttccctgaagccattt
ggagtgactgtttaccatggcctcaggcagccctatgcaagaaatccatgtgcacatgaa
aatgggggctgtcagcacatctgtgtcctcagccacagaacattcaatggtggtttgggt
taccgttgcaagtgtaggcttggctacattccggattgggacgactatcactgtgttgct
gctgagcggtttctgctcttttcatctaatctggctgttcgtggcatcccactcaccctc
tctcaccagacggaggtcatccttccagtgacaggatcttcttccatcttccttgggatt
gattttgatgcccgcgagaaggctatctttttttcagatacaaagaaaaacattatttac
agacaaaagctcgatggtacaggaagagaaattatcacagctaacagggtgccagctgtt
caaagtttgagttttgattggatttcgaggaatctctattggacagattcttcttatagg
agtgtcagtgtcataaggctagctgataaatcaagacgtacaatcatccagaatttaaat
aacccacagtcaatcgtagttcatccgactgctgggtatatattcttctcggtttggtac
cgtcctgctaaaatcctgagagcatgggctgatggatctaacattttacctatagtaaac
actactcttgggtggcccagtgggctgtccattgattggagttcttcacgattgtactgg
gtagatgccttttttgataaaattgagcacagtaactttgatggttcagacagaaaagcc
ctgaccaatgtacatcagttgacacatccatttggacttgctgtctctcaagactatata
tatgttactgattggagacgtggtattattcgattcgggaaatacaatcctggacaatcg
attattctccgaagtggtgttggttctgtgatgcgtgcgaaagtatatgattctagagtc
cagacagggtctaatgcctgtagccggcccaccaatccaaacggcgactgcagccacttc
tgctttccagtgccgaattcccagcgggtgtgtggttgcccctatggaatgagtctggct
tctgatcatttgacttgtgtggagaatgcctcccgagagccgccggtggagcagtgtggc
actctttccttctcctgtcacaacggcagatgcgtgccccttcagtatcgctgtgacgga
ttcgatgactgtcttgataacagtgatgaggctcaatgtaccacatctaatgctacctgt
tcacctttagcatttgagtgtaaacgcgaaggacactgcattccctcaatgtggcgctgt
gacggagaggatgattgtctggatggcagcgatgagcagaactgccccactcgagcaccc
acttcctgccgtgctgatcaattcacctgtgacaataacttctgtatcccaaggagctgg
gtctgtgacacagataatgattgtaaggatggatcagatgaaaagtcatgcaattataca
cagacatgttcacctactcagtttcactgccctgatcaccgatgtattgccctaactttt
gtctgtgatgggaccaaggactgtgctgatgggtctgatgagattggttgtgtaattaac
tgcactgcttctcaattcacatgtgttagtaatggtcagtgtattagcaagacatatcgc
tgtgatggtgtttttgactgtgatgaccactctgatgagacagattgtccaaccaggcct
cctggtatgtgccaccaagatgaattccagtgccaagaagatgggatctgcattccaaag
acctgggaatgtgatgggcatgaggactgcctccagggatctgatgagcacaatggctgt
ccccccaaaacctgccatccttctcatttcgtctgtcagaatggaaactgcatctataga
aattggctctgtgatggggacaatgattgcggagacatgagcgatgagaaggactgccct
actcagccttttcagtgtcccagttggcagtggcaatgccccggccatagcatctgtgtg
aatctgagtgcagtgtgtgatggtgtctctgactgccccggtgggacagatgagtcccca
ctttgcaaccagaatagctgctcagattccaatggtggttgtactcaccagtgtattcaa
gggccttatggggcccaatgccagtgtccattgggatatctgcttggcaatgactctaag
acctgcgaagacatagatgaatgtcatactccaggcttttgtagccagtactgttacaac
atgagaggttctttccggtgctggtgtgattcagaatacacgctagatgctgatcggagg
acttgtaaagctacagaatctgaaactctgttactggtggcgagtcagagccagcttgtt
gctggcaatatgacccagaatgggtactttgtctacccagttatccaacatggttctcac
attgtggctgttgattttgattcagtcagtgatcgtatcttttggtctgatggaactcag
ggtaaaatctggagtgcgtttcaaaatggaacagataaaaaactaatacttgacagtggt
gtcagcatgactggaagtattgcagtagattggataggacgcaatctttactggacagac
atttccctgcgaacaattgacgtcgcgaaactggatgggagccacaagaccgtgctgatt
agtgaaaacataacaaatctagggggactagcagtagatcccagagctactgaccgtgtg
atgttctggtctgactggggcagtcaccctcgcattgagcgagctagcatggatggcagt
cagcgcaccatcattgtgcaggagaagatctactggcccaatggattagctcttgactac
cccaacaggctactctatttcatggatggctatcttgattacctagacttctgtcactac
gatggaagcaatcggaggcaggtgatagccagtgatttgattctgcgccatccttactcc
ataagtctttttgaagatactgtgtactggagcgatcgtgctactcatgaggttatgaaa
gccaataagtggcatggggggaaccagtcagtggtgatgactcttcaccagcctcttggc
attgttgtggttcatcctgcaaaacagccagtttcctcaaatccgtgcagctatacccga
tgcagccatctgtgcctgctttcctcaaagagcctttactcctgtgcttgtccttctggg
tggactcttgctcgtgattctgtgacttgcgtgagagatgatcaagcattcctaatagtt
gtaagaaacagtataatttttggaatttcccttaatcctgatgtgaagacctttgatggg
atggtgcccatatcagggatacgcaatggttatgatgttgcagttgattattcagagcag
ttcatctattggcttgaaaatccaggtgaaattcacagagtgaagacagacggaaccaac
aggacagtgtttgctcctctgtcaagtttgggggcttctgcgagcctggccttagactgg
ctatcaagaaacctttattttactgatcacgtgactcgatcaattaaggttatgacactt
cgaggagatgtcagttacaggaaaaccctgattgccaatgatgggacgagtcttggagtt
ggtttgccagttggcataactatcgatcctattagtgggaaactgtactggtcagaccga
ggaaccaacagtggccttccccccaagattgccagcgctaacatggatggcaaatctcca
agaactctctttactgggagccttgaaaatgtggcatttatcacccttgatattgaggag
caaaaactctactgggcagtcagcagcacgggagtgattgaaagaggaaatgtggatgga
acaaatcgaatgatcctggtaaaccatctttcctacccctggggacttgctgtccatggc
cccttcctttattactccgatgaagaatatgaggtcattgaaagagttgacaaggctaca
ggggccaacaaagtagtcttgagaaataatctcccagatctcaggggccttaaaatttac
caaagacgtggctctgaatcctcaaacggctgcagcaacaacatgaatgcctgtcagcaa
atttgcctgcctgtaccaggaagactgttctcctgtgcctgcgccactggatttaaactc
aatcctgatcatcagacctgctctccatacaattctttcattgttgtttccacactgcgg
acaatcaggggctttagcttgcaattgtcagatcattcagaagccatggtgccagtggca
ggcccaggacgaaatgcactgcatgtggatgtggacgtatcttctggctttatttattgg
tgtgattttaacgtctctgtggcatctaataatgcaatccgtagaatcaaaccagatggg
tctaattttacaaacatcgttacagatgggataggagtaaatggagtccggggtattgca
gtggattgggtagcaggaaatctttatttcaccaatgcttttagatctgaaacactgata
gaagttctaaggatcaataccacccaccgccacattctccttaaaaccatagtggatatg
cccagagacattgttgtggaccccaagaatcgatacctcttctggtctgactatgggcag
aacccaaagattgaacggtcttttcttgactgtaccagtcgaactgtgcttgtatcagac
atcactgccacaccacggggcttggcattggatcatagcagtaactacatttattgggtt
gatgatgctgtagatttaattgcaaggatcagcattgagggaggggaaactgaagtgatt
cgtttcggcagtcattacccagctccttatgccatcaccgtatttggaaattctatcata
tgggtagataggaatttaaagaaaatcctccaagccagcaaggaaccaaatagagcagat
cgaccaacagtgataagggacaatattgattggctaagagatgtgaccatctttgaccag
agtgtccagcctcggtcaccagcagaggtcaacaacaacccttgcttggaaaataatgga
ggatgcgcccaattctgctttgctctgcctaaatcacaaacccctaaatgtgactgtgcc
tttgggaccctgcaagctgatggtaggagctgtgccatttcatcagaaaatttcctcatc
tttgctttggatgattccttgaggagcttacgttttgaccccaaagactatagccaacct
ttcccagcaataagtgtggaaagaatggctgtggccctagactatgacagcatagataac
agaatctacttcacacaacttttgccatccggaaaaggccagatttcctatatcaacctg
aattcaaggagcagtcctcccactgttgttgtttcgggcatagggagtcctgagggcatt
gcctttgactggatcaataaaagaatttattacagtgactacaccaatcagatgattaag
tccattgccacggatgggtctagacacactctgatagcccaagttccaaagccaagagga
attgtgttagatccttgccaagggtacatgtattggactgactggggtaccaatgccaaa
atcgagatggccacaatgggtggatactcccggagaagcttggtggacaggggcctggtc
tggcccaacgggctcactctggactatgaacaaaaccttatctactgggcagatgctaat
ctggagaagattgagcgcatggatctagagcactatctgagggaggtcattgtcagcaga
gccaatagtccttttggcttggctatttatggccagtatgtttactggactgacttgctc
actcagaaaatttatcgagctaacaaagttgatgggtcagggcagactgcagtgaccgtg
acccttccctttcggcctaagggtattcgtgctgttgtgaaggaccaacaacaatgtctc
agtccttgcgatcggtttaatgggggctgtagccatatttgtgccccaggtccaaatggc
gctgagtgccagtgtccacatgagggccgctggtacctggccaacaacaataagtactgt
atccaggataatggtacccggtgtgacagttccaagttcacctgcctcagtgggaagtgc
atccctgaccagttgcaatgtaatgacatcgacgactgtggtgacagcagtgatgagctg
gaaactctctgtgcgtttcacagctgcccttcgacaagcttcacctgcgccaacgggcgg
tgtgtgccatacagtgatcgctgtgaccactacaatgactgtggcgacaacagcgatgag
gccgggtgccacttcagggcttgtaacagaacagaatttacttgcagtaacggaaggtgc
atcccttctgaattagtctgcgatggggtagacaactgccttgacaacagtgcttcagac
gagaaaaactgccctgaacgcacgtgccatcctggatatgtaaagtgtacgaattcaacg
atttgtattccacgttctttcttgtgtgatggagacaacgattgtggagatatgagtgat
gaaaacccccttttctgtgccactcggtcgtgtgggagcgatgagttccattgcacctct
gggccctgtattcctgcacgttggtattgtgatcatgaaaaagactgttctgacggctct
gacgaacctcccacttgtgagttttctcagtcaacgtgcgccagtgattatttcaagtgt
gacaataacaggtgcatcccaatgatgtgggtctgtgatggtgataatgactgtggagac
atgagtgatgaggatgaaagacataactgcacttcagagaatcgcaactgctcaagttct
gagtttgcctgtgaggttggtgtgcgtccacacagaggctgtatccctaaatcgtgggtt
tgtgatggtgaagcagattgccttgatgcccttgatgagcaccagaattgcaccagaaga
tcctgctttggaacagagttcgtctgtaataatggcttgtgtatccccaaccacttcagg
tgtgaccggaacaatgactgtggtgactacagtgatgagaggggctgtgtgtaccctacc
tgcgacgagaccctttttacgtgtcagaacggactctgcattaataaggcctatgtctgt
gatggggacaatgactgtaaagataactctgatgagctggagcacctgtgtcacacccca
gaaaccacatgcccccctcatcagttcaggtgtgacaatgggaactgcattgagatgatg
aaagtctgtaacaacttccctgactgctcagacaacagtgatgagaaaggatgtggcatt
aatgagtgcaatgaccctacactcagtggttgtaaccaaaactgcacagacaccttaacc
agtttctattgttcttgtaaccctggttacaagctgttgtctgacaagaggacttgtgtt
gatattgatgaatgcgaggagacgcccttcgtctgtagccaaaagtgtgagaacttacct
ggcacttacatctgcaaatgtgccccaggctacatccgtgagccagatggaaagacctgc
cggcagaacagcaacatagagcctgatctcatttttagcaaccgttactatttgagaaat
ctaactgtctatggccatttatactccctcatcttgcaaggactgggtaatgttgtggca
ttggattttgaccgagtagaaaagagattgtactggcttgatatagagaataaagtcatt
gagagaatgtttgtgaatacgacaaacagggagacagtcttaaagcacaatctacctggt
gcggaaagtctggctgtcgactgggttaccagaaagctctattgggtggattcctacctg
aattgcctttctgtctctgacctcaatggtcgataccgccgcaagttggctgagcactgt
gtggatgccaacaacaccttctgctttgagaatcctagaggacttgcacttcaccctcga
tatgggcacgtctactgggcagactggggtgaccgagcatacattgggagagtaggcatg
gatggaacccttaagtctctgattatctctaccaagatcatgtggcccaatggcctcacc
attgattacaccaatgatctactctactgggcagatgcccacctgggttacattgagtac
tctgatttggagggccgccatcggcacacagtatacgaaactggcacactgtctcacccc
tttgctattaccatttttgaagacaccatttattggacagattggaatacaaagacagtt
gagaagggaaacaaatacaatgggtcagatagagtggcgctgttgaatgtaacacacagg
ccatatgacatccatgtctatcatccttataggcagccaattgtgcctaatccctgtggt
acgaacaacggtggctgttctcatctctgcctcatcaaagaaggaggtgttggattcact
tgcgagtgtccagataacttctacaccgtccagcatggtcccaacacccagtgcctgccc
atgtgctccagcacccaattcctgtgtgccgacagcgaaatgtgtattcctatctggtgg
aaatgtgacgggcggagagactgcttggatggttccgatgaacctatcacttgcccacag
cgcttctgcgcattaggaatgttccagtgcaatgatggcaactgcaccaactcacactcc
ctatgtaatttgcgtcaggattgccctgatgggtcggatgaagaccctgtgctttgtgag
catcaccagtgtgagccctacgaatggcagtgcgccaacaaacgttgcattccggagtcc
tggcagtgtgacatgcaggacgactgtgacgataactcggacgaagacagctcgcactgt
gccagcaggacctgccggcctggctacttcaagtgcgccaacggccactgcatccctcag
atatggaagtgtgacgtggacaacgactgcggagactactcagacgagcccttgcaggaa
tgcttgggcccctcctatcgctgtgataactatacggaattcagctgtaaaacaaactac
cgctgcatcccgaagtgggccgtgtgcaacggcgtcgacgactgcagggacaacagtgac
gagcaggactgtgagtcgatgacatgcaaaccttctggggaatttcggtgtacaaatcac
cgctgcatccctcttcgctggagatgtgatgggcaaaatgactgtggagaccgctctgat
gaggaaaactgtgccccccggaaatgcacggagagcgagtttcgatgtgatgatcagagc
tgtattccttctcgatgggtctgtgaccaaaccaatgactgtggggacaactcagatgag
cgggactgcgagatgatgacctgccgtcctggatattttcagtgtgatagcgggcactgt
atttctgaacatatgaagtgcaatggggtggctgactgtcgcgatgcctctgatgaagcc
aattgtcccacccgctttcccaatggtgcatactgcccagctactatgtttgaatgtaaa
aatcacgtttgtatccattcatcatggaaatgtgatggtgataatgactgtggcgatggt
tccgatgaagaactccatctgtgcttaaatgttgcctgtgactcaccataccgtttccgg
tgtgacaacaatcgctgcatttatcgtcatgaggtgtgcaaccaggaggatgactgtgga
gatggaagtgatgagaaaaaggagctctgtgtagaaccgactcctagaccttgtacacca
gatgaatttaagtgtagcaatgggcgttgcattccacagcaccgggtgtgtgatcatgtt
aatgactgtggtgacaatttcgatgagacaggatgcaatacaggaaaagacagatcatgt
gctgaaaatctgtgtgaacacaactgtacccagttacgtgaaggaggattcatctgctcc
tgtagacctggattcaaacccaatagtattgacagaaacctctgtgaagacatcaatgaa
tgtatgcagttcgggagttgtcctcagatctgccataacaccaaaggaagttatgagtgt
tcctgcgctgaagggttcacatctctgagtgacagatatggagaacggtgtgcggctgac
ggtagtcctcctttgctgctactgcctgaaaatgtgagaattcgaaaatacaacctctca
tctcttcagttctcagagtaccttgaagaccaggagcgcattaaggctatggattatgat
tgggatccggagggcacaggcctcagtgttgtatattacactgtgctaggggagggctct
aattccggtgctatcaaacgtgcctacattcccaactttgaatctggaagcaataatcct
gtgatggaaattaacctggacctgaaatacatagtgcagcctgatggattggcagtggac
tgggttggaaggcatatttactggtcagatgccaggagacaacggattgaagtggctgaa
cttgatggaaggtacagaaagtggctgatttccactgaactgggtcaaccagctgcaata
gttgtgaatcccaagctagggtttatgtactggactgactggggcgaaaatcctaaaatc
gagtccgcttggatggatgggcagcgtcggaaagtcttggttcaggaggacctcggttgg
ccaacaggcctctgtatagattatatgaatggtgaccggatctactggagtgacctcaag
gacaacattgttgaaaccatcaaatatgatggaaccgataggagaattgtggtaacttca
gcggtgaacccttatagtctggacatctttgagagccagttatactggacatctaaggat
aagggagaagtgtggatccaagataaatttgggagaaacaagaaagagaaattgctgaca
gtgaacccttggcttactcaagttcgagtcttccatcaacggaaatataatcattcagtg
cccaatcgctgtaaggatgtctgcagccacttatgccttctgagacctaagggatacacc
tgcgcctgtccccaaggctccagatttctagaagggagcgtcacagtgtgtgatgcagcc
attgtaggtgctgtcagcatgccccctccatgcaggtgtatgaacagaggaagctgctat
tttgatgagaataacctccccaaatgcaagtgttctagtggctacgtgggagaatattgt
gaaatggggctttcccaaggcgttcctccaggaacaacggcgtccgtgctattgacagtc
atcttgatcgtcataattgctgctttagccactttagggtttctccactatcggaaaact
ggctccattttgccttctctgccaaagctgtcaagcttaagccatctcaaatcctctgaa
aatggaaatggggtgaccttcagatcaggggatgatgtgaacatggatatcggagtaact
ggttttgggcccgagtctgctattgacagatcgctggcgatgaatgagcattttgccgca
gacttcgggaagtcgcccataatatttgagaacccgacatactcctccaaggacactgct
atcacagtggctcagccaacaacagccccggtaactgaatctgcaacagtgtataacaaa
aactatggaagccccataaaccctgctgaactagttacagacacaaagccaacttcctca
agtgatgaaactcagccaacaaaatggaatatcttcaaacgaaaaccgaaacaaaatacc
aactttgaaaatccattctattccgagatggagaatgaaccaaaggtcggtgctgctgtg
accccacctccatcaccttctcctcctgctaaggtttcttggaaaaaaggctcaactcca
ggctacagtgcaacagaagacacatttaaagacactgcaaatcttgtgagagaagactcg
gaggcataa

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