KEGG   Bison bison bison (American bison): 104995620
Entry
104995620         CDS       T08726                                 
Name
(RefSeq) mitogen-activated protein kinase 1
  KO
K04371  mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
Organism
bbis  Bison bison bison (American bison)
Pathway
bbis01521  EGFR tyrosine kinase inhibitor resistance
bbis01522  Endocrine resistance
bbis01524  Platinum drug resistance
bbis04010  MAPK signaling pathway
bbis04012  ErbB signaling pathway
bbis04014  Ras signaling pathway
bbis04015  Rap1 signaling pathway
bbis04022  cGMP-PKG signaling pathway
bbis04024  cAMP signaling pathway
bbis04062  Chemokine signaling pathway
bbis04066  HIF-1 signaling pathway
bbis04068  FoxO signaling pathway
bbis04071  Sphingolipid signaling pathway
bbis04072  Phospholipase D signaling pathway
bbis04114  Oocyte meiosis
bbis04140  Autophagy - animal
bbis04148  Efferocytosis
bbis04150  mTOR signaling pathway
bbis04151  PI3K-Akt signaling pathway
bbis04210  Apoptosis
bbis04218  Cellular senescence
bbis04261  Adrenergic signaling in cardiomyocytes
bbis04270  Vascular smooth muscle contraction
bbis04350  TGF-beta signaling pathway
bbis04360  Axon guidance
bbis04370  VEGF signaling pathway
bbis04371  Apelin signaling pathway
bbis04380  Osteoclast differentiation
bbis04510  Focal adhesion
bbis04520  Adherens junction
bbis04540  Gap junction
bbis04550  Signaling pathways regulating pluripotency of stem cells
bbis04611  Platelet activation
bbis04613  Neutrophil extracellular trap formation
bbis04620  Toll-like receptor signaling pathway
bbis04621  NOD-like receptor signaling pathway
bbis04625  C-type lectin receptor signaling pathway
bbis04650  Natural killer cell mediated cytotoxicity
bbis04657  IL-17 signaling pathway
bbis04658  Th1 and Th2 cell differentiation
bbis04659  Th17 cell differentiation
bbis04660  T cell receptor signaling pathway
bbis04662  B cell receptor signaling pathway
bbis04664  Fc epsilon RI signaling pathway
bbis04666  Fc gamma R-mediated phagocytosis
bbis04668  TNF signaling pathway
bbis04713  Circadian entrainment
bbis04720  Long-term potentiation
bbis04722  Neurotrophin signaling pathway
bbis04723  Retrograde endocannabinoid signaling
bbis04724  Glutamatergic synapse
bbis04725  Cholinergic synapse
bbis04726  Serotonergic synapse
bbis04730  Long-term depression
bbis04810  Regulation of actin cytoskeleton
bbis04910  Insulin signaling pathway
bbis04912  GnRH signaling pathway
bbis04914  Progesterone-mediated oocyte maturation
bbis04915  Estrogen signaling pathway
bbis04916  Melanogenesis
bbis04917  Prolactin signaling pathway
bbis04919  Thyroid hormone signaling pathway
bbis04921  Oxytocin signaling pathway
bbis04926  Relaxin signaling pathway
bbis04928  Parathyroid hormone synthesis, secretion and action
bbis04929  GnRH secretion
bbis04930  Type II diabetes mellitus
bbis04933  AGE-RAGE signaling pathway in diabetic complications
bbis04934  Cushing syndrome
bbis04935  Growth hormone synthesis, secretion and action
bbis04960  Aldosterone-regulated sodium reabsorption
bbis05010  Alzheimer disease
bbis05020  Prion disease
bbis05022  Pathways of neurodegeneration - multiple diseases
bbis05034  Alcoholism
bbis05132  Salmonella infection
bbis05133  Pertussis
bbis05135  Yersinia infection
bbis05140  Leishmaniasis
bbis05142  Chagas disease
bbis05145  Toxoplasmosis
bbis05152  Tuberculosis
bbis05160  Hepatitis C
bbis05161  Hepatitis B
bbis05163  Human cytomegalovirus infection
bbis05164  Influenza A
bbis05165  Human papillomavirus infection
bbis05166  Human T-cell leukemia virus 1 infection
bbis05167  Kaposi sarcoma-associated herpesvirus infection
bbis05170  Human immunodeficiency virus 1 infection
bbis05171  Coronavirus disease - COVID-19
bbis05200  Pathways in cancer
bbis05203  Viral carcinogenesis
bbis05205  Proteoglycans in cancer
bbis05206  MicroRNAs in cancer
bbis05207  Chemical carcinogenesis - receptor activation
bbis05208  Chemical carcinogenesis - reactive oxygen species
bbis05210  Colorectal cancer
bbis05211  Renal cell carcinoma
bbis05212  Pancreatic cancer
bbis05213  Endometrial cancer
bbis05214  Glioma
bbis05215  Prostate cancer
bbis05216  Thyroid cancer
bbis05218  Melanoma
bbis05219  Bladder cancer
bbis05220  Chronic myeloid leukemia
bbis05221  Acute myeloid leukemia
bbis05223  Non-small cell lung cancer
bbis05224  Breast cancer
bbis05225  Hepatocellular carcinoma
bbis05226  Gastric cancer
bbis05230  Central carbon metabolism in cancer
bbis05231  Choline metabolism in cancer
bbis05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
bbis05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:bbis00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    104995620
   04012 ErbB signaling pathway
    104995620
   04014 Ras signaling pathway
    104995620
   04015 Rap1 signaling pathway
    104995620
   04350 TGF-beta signaling pathway
    104995620
   04370 VEGF signaling pathway
    104995620
   04371 Apelin signaling pathway
    104995620
   04668 TNF signaling pathway
    104995620
   04066 HIF-1 signaling pathway
    104995620
   04068 FoxO signaling pathway
    104995620
   04072 Phospholipase D signaling pathway
    104995620
   04071 Sphingolipid signaling pathway
    104995620
   04024 cAMP signaling pathway
    104995620
   04022 cGMP-PKG signaling pathway
    104995620
   04151 PI3K-Akt signaling pathway
    104995620
   04150 mTOR signaling pathway
    104995620
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    104995620
   04148 Efferocytosis
    104995620
  09143 Cell growth and death
   04114 Oocyte meiosis
    104995620
   04210 Apoptosis
    104995620
   04218 Cellular senescence
    104995620
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    104995620
   04520 Adherens junction
    104995620
   04540 Gap junction
    104995620
   04550 Signaling pathways regulating pluripotency of stem cells
    104995620
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    104995620
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    104995620
   04613 Neutrophil extracellular trap formation
    104995620
   04620 Toll-like receptor signaling pathway
    104995620
   04621 NOD-like receptor signaling pathway
    104995620
   04625 C-type lectin receptor signaling pathway
    104995620
   04650 Natural killer cell mediated cytotoxicity
    104995620
   04660 T cell receptor signaling pathway
    104995620
   04658 Th1 and Th2 cell differentiation
    104995620
   04659 Th17 cell differentiation
    104995620
   04657 IL-17 signaling pathway
    104995620
   04662 B cell receptor signaling pathway
    104995620
   04664 Fc epsilon RI signaling pathway
    104995620
   04666 Fc gamma R-mediated phagocytosis
    104995620
   04062 Chemokine signaling pathway
    104995620
  09152 Endocrine system
   04910 Insulin signaling pathway
    104995620
   04929 GnRH secretion
    104995620
   04912 GnRH signaling pathway
    104995620
   04915 Estrogen signaling pathway
    104995620
   04914 Progesterone-mediated oocyte maturation
    104995620
   04917 Prolactin signaling pathway
    104995620
   04921 Oxytocin signaling pathway
    104995620
   04926 Relaxin signaling pathway
    104995620
   04935 Growth hormone synthesis, secretion and action
    104995620
   04919 Thyroid hormone signaling pathway
    104995620
   04928 Parathyroid hormone synthesis, secretion and action
    104995620
   04916 Melanogenesis
    104995620
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    104995620
   04270 Vascular smooth muscle contraction
    104995620
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    104995620
  09156 Nervous system
   04724 Glutamatergic synapse
    104995620
   04725 Cholinergic synapse
    104995620
   04726 Serotonergic synapse
    104995620
   04720 Long-term potentiation
    104995620
   04730 Long-term depression
    104995620
   04723 Retrograde endocannabinoid signaling
    104995620
   04722 Neurotrophin signaling pathway
    104995620
  09158 Development and regeneration
   04360 Axon guidance
    104995620
   04380 Osteoclast differentiation
    104995620
  09159 Environmental adaptation
   04713 Circadian entrainment
    104995620
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    104995620
   05206 MicroRNAs in cancer
    104995620
   05205 Proteoglycans in cancer
    104995620
   05207 Chemical carcinogenesis - receptor activation
    104995620
   05208 Chemical carcinogenesis - reactive oxygen species
    104995620
   05203 Viral carcinogenesis
    104995620
   05230 Central carbon metabolism in cancer
    104995620
   05231 Choline metabolism in cancer
    104995620
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    104995620
  09162 Cancer: specific types
   05210 Colorectal cancer
    104995620
   05212 Pancreatic cancer
    104995620
   05225 Hepatocellular carcinoma
    104995620
   05226 Gastric cancer
    104995620
   05214 Glioma
    104995620
   05216 Thyroid cancer
    104995620
   05221 Acute myeloid leukemia
    104995620
   05220 Chronic myeloid leukemia
    104995620
   05218 Melanoma
    104995620
   05211 Renal cell carcinoma
    104995620
   05219 Bladder cancer
    104995620
   05215 Prostate cancer
    104995620
   05213 Endometrial cancer
    104995620
   05224 Breast cancer
    104995620
   05223 Non-small cell lung cancer
    104995620
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    104995620
   05170 Human immunodeficiency virus 1 infection
    104995620
   05161 Hepatitis B
    104995620
   05160 Hepatitis C
    104995620
   05171 Coronavirus disease - COVID-19
    104995620
   05164 Influenza A
    104995620
   05163 Human cytomegalovirus infection
    104995620
   05167 Kaposi sarcoma-associated herpesvirus infection
    104995620
   05165 Human papillomavirus infection
    104995620
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    104995620
   05135 Yersinia infection
    104995620
   05133 Pertussis
    104995620
   05152 Tuberculosis
    104995620
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    104995620
   05140 Leishmaniasis
    104995620
   05142 Chagas disease
    104995620
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    104995620
   05020 Prion disease
    104995620
   05022 Pathways of neurodegeneration - multiple diseases
    104995620
  09165 Substance dependence
   05034 Alcoholism
    104995620
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    104995620
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    104995620
   04933 AGE-RAGE signaling pathway in diabetic complications
    104995620
   04934 Cushing syndrome
    104995620
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    104995620
   01524 Platinum drug resistance
    104995620
   01522 Endocrine resistance
    104995620
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:bbis01001]
    104995620
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:bbis03036]
    104995620
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:bbis04147]
    104995620
Enzymes [BR:bbis01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     104995620
Protein kinases [BR:bbis01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   104995620
Chromosome and associated proteins [BR:bbis03036]
 Eukaryotic type
  Centromeric chromatin formation proteins
   SAC (spindle assembly checkpoint) factors
    Protein kinases
     104995620
Exosome [BR:bbis04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   104995620
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 APH RIO1 STATB_N Haspin_kinase FTA2 Kdo Kinase-like
Other DBs
NCBI-GeneID: 104995620
NCBI-ProteinID: XP_010847874
Ensembl: ENSBBBG00000006804
UniProt: A0A6P3I7Q3
LinkDB
Position
Unknown
AA seq 332 aa
MLSPLTPLSFFSSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGIND
IIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHR
DLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKS
IDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLP
HKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPVAEAP
FKFDMELDDLPKEKLKELIFEETARFQPGYRS
NT seq 999 nt   +upstreamnt  +downstreamnt
atgctgtctcccctcacccccctttctttttttagctctgcttatgacaatgtcaacaaa
gtccgagtcgccatcaagaaaatcagcccttttgagcaccagacgtactgccagagaacg
ctgagagagataaagatcttactgcgcttcagacatgagaacatcatcggaatcaatgac
attattcgagcaccgaccatcgagcagatgaaagatgtgtatatagtacaggacctcatg
gaaacagatctctacaagctcttgaagacgcaacacctcagcaacgaccacatctgctat
tttctttaccagatcctcagagggttaaagtatattcattcagccaacgtgctgcaccgt
gacctcaaaccttccaacctgctgctcaacaccacctgcgatctcaagatctgtgacttt
ggcttggcccgtgttgcagatccggaccatgaccacacagggttcttgacagagtacgtg
gccactcgctggtaccgggctccagaaatcatgttgaattccaagggctacaccaagtcc
atcgacatctggtccgtgggctgcatcctcgcggagatgctctccaacaggcccatcttc
cccgggaagcactaccttgaccagctgaaccacattctgggtattcttggatccccgtcg
caggaagacctgaattgtataataaatttaaaagctagaaactacctgctctctcttcca
cacaaaaataaggtgccatggaacaggctgttcccgaacgcggactccaaagctctggat
ctactggacaaaatgttgacgttcaaccctcacaagaggatcgaggtggagcaggctctg
gcccatccttacctggagcagtactacgacccgagcgatgagcccgtcgccgaagcaccc
ttcaagtttgacatggaattggatgacttgcccaaggaaaagctcaaagaactcattttt
gaagagactgctagattccagccgggataccgatcttaa

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