Bison bison bison (American bison): 104998063 Help Entry 104998063         CDS       T08726                                  Symbol HMCN1 Name (RefSeq) hemicentin-1 isoform X1   KO K17341   hemicentin Organism bbis  Bison bison bison (American bison) Brite KEGG Orthology (KO) [BR:bbis00001]  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04990 Domain-containing proteins not elsewhere classified [BR:bbis04990]     104998063 (HMCN1) Domain-containing proteins not elsewhere classified [BR:bbis04990]  EGF-like domain-containing proteins   hEGF / cEGF domain-containing proteins    104998063 (HMCN1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  I-set Ig_3 Ig_2 ig V-set C2-set_2 Ig_5 TSP_1 EGF_CA VWA_4 G2F V-set_CD47 cEGF C1-set TSP1_spondin Receptor_2B4 GBD_Hemicentin TSP1_CFP_C FXa_inhibition EGF_3 TSP1_ADAMTS Fibulin_C EGF Motif Other DBs NCBI-GeneID:  104998063 NCBI-ProteinID:  XP_010851374 Ensembl:  ENSBBBG00000023377 UniProt:  A0A6P3IHG6 LinkDB All DBs Position Unknown AA seq 5635 aa AA seqDB search MISWDMIHTIFLLALLYPSRAQDAIPQSEVEAEEIPEGASTLAFVFDVTGSMYDDLVQVI EGASKILETSLKRPKRPLFNFALVPFHDPEIGPVTVTTDPKKFQYELRELYVQGGGDCPE MSIGAIKIALEISLPGSFIYVFTDARSKDYRLTHEVLQLIQQKQSQVVFVLTGDCDDRSH IGYRVYEEIASTSSGQVFHLDKKQVNEVLKWVEEAVQASKVHLLSTDHLEQAENTWKIPF DPSLKEVTVSLSGPSPMIEIHNPLGKLIKKGFGLNELLNIHNSAKVVNVKEPEAGIWTVK TSSTGRHSVRITGLSTIDFRAGFSRKPTLDFKKTVSRPVQGIPTYVLLNTSGISIPAKVD RLELLSISGSSLKTIPVKYYPDRKPYGIWNISDFIPPNEAFFLKVTGYDKDDFLFQRVSS VSFSSIVPDAPKVTMPEKTPGYYLQPGQIPCAVDSLLPFTLSFVRNGATLGVDQYLKESA SVTWDIEEVTLADEGAYECVAVSTAGIGRAQTFFDVSEPPPVIQVPSNVTVTPGETAVLT CLVVSAVGYNLTWQRNDRDIRLTDTAGMRILANLSLELRSVKFSDAGEYRCVVSNEGGSS TEAVFLTVQEPPKVTVMPKNQSFTAGSEVSIMCSATGYPKPKIAWTVNDVFIMGSHRYRM TSEGNLFIKNAVPKDAGIYGCLASNSAGMDKQTSTLRYIEAPKLIVVQSELLVALGDTTV MECKTSGVPPPQVKWFKGDLELKPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAVNDAGR ATGRITLDVGSPPVFIQEPTDVSVEIGSNVTLPCYVQGYPEPKIKWRRVDNMPIFSRPFS VSSISQLRTGDLFISNLWASDKGTYICEAENQFGKIQSQTTVTVTGLVAPLIGISPPVTS VIEGQQLTLPCALLAGNPIPERRWIKNSAMLVQNPYITVRSDGSLHIERVRLQDGGEYTC VASNVAGTTNKTTTVDVHVLPTIQHGQQILSTIEGIPVTLPCKASGIPKPSIAWSKKGEL ISSSNAKFSAGADGSLYVVSPGGEESGEYVCTATNAAGYAKRKVQLTVYVRPRVFGDQRG PSQDKPVEISVFAGEEVTLPCEVKGLPPPIITWAKETQLISPFSPRHTFLPSGSMKITET RVSDSGMYLCVATNIAGNVTQSVKLNVHVPPKIQRGPKVMKVQVGQRVDIPCSAQGTPLP VITWFKGGGAVLVDGLQHIRHPDGTLSIKQAVLSDAGIYTCVATNIAGSDETEITLHVQE PPILEDLEPPYNTPFQERVANQRIAFPCPAKGTPKPTIKWLRNGRELTGQEPGISILEDG TLLVIASVTPYDNGEYICVAVNEAGTTERRYNLKVHVPPVIKDKEQVTNVSVLVNQPTSL FCEVEGTPSPIIMWYKDDVQVTESSSIQIVNNGKILKLFRTSPEDAGRYSCKAINVAGTS QKHFNIDVLVPPTIIGAGSPGEVSVVLNQNTTLECRVKGTPFPVIRWLKDGKPLFLGDPN IEILDRGQVLHLKNARRSDKGRYQCSVSNAAGKQAKDIKLTIYIPPSIKGGNVTTEVSAL INSIIKLECETRGLPMPAITWYKDGQPVISSSQALYVEKGQFLHIPRAQVSDSAAYKCLV TNVAGTAEKSFHVDVYVPPVIEGDLAEPLNKQVKVAHSLTLECKAAGNPPPVLTWLKDGV PVKASDNIRIEAGGKKLEITSALEVDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDE TSYFIVMVNNLLELDCQVTGSPPPTIMWLKDGQLIDERDGFRILLNGHKLVIAQAQVSDT GLYRCVATNTAGDHRKEFEVTVHVPPTIKPSGLSERAVLKYKPITLQCTANGVPNPSITW LKDGQPVNTAQGNLKIQSSGRLLQIAKALMEDAGRYTCVATNAAGETQQHIQLHVHEPPS LDDAGKMLNETVVVNSPVQLECKAAGTPSPAITWYKDNRPLSDSSSVTFLNRGQIINIES AQITDAGIYKCVAINSAGATELFYSLQVHVPPSIFGSNNMVAVVVNNLVRLECEARGIPA PSLTWLKDGSPVTSFVNGIQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRV YVAPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSVTENGSVLK IEDAQVQDSGRYTCEATNVAGKTEKNYNVNIWVPPNISGSDEAAQLTVIEGHLISLLCES SGIPPPNLIWKKKGSPVLADSAGRVRILSGGRQLQISIAEKSDAGLYSCMASNVAGTAKK DYSLQVYIRPTISNSGSHPTEIIVTRGKSVSLECEVEGVPQPAVTWMKDGRPLTKGRGME IMDEGRMVQLKNVHVSDTGRYMCVAMNIAGMTDRKYDLSVHTPPSIIGNHRTPENISVVE KSSVSLNCEASGIPLPSITWLKDGWPVNLSSSLRILSGGRILRLMQTRTEDAGQYTCVVR NAAGEERKIFRLSVLVPPHIMGENTFEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQLL KEDDTHHLMSDGRFLQIVNAQVSHTGRYTCLASNTAGDKSKSFSLNVLVSPIIAGVDGDG SPEDITVILNSPTSLVCEAYSYPPATITWFKNGTPLESNQNIRILPGGRTLQILNAQEDD AGRYACVATNEAGEMIKHYEVKVYIPPIINKGDLLGPGLSPREVKIKVNNTLTLECEAYA IPSASLSWYKDGQPLKSDDHVTIAAGGHTLQIKEAQISDTGRYTCVASNVAGEDELDFDV NIQVPPSFQKLWEIGNRVDTGRRGEAKDVIINNPISLYCETNAAPAPTLTWYKDGHPLTS SERVLILPGGRVLQIPRAKVEDAGRYMCVAVNEAGEDSLQYDVRVLLPPVIKGANGDLPE EVTVLVNKSVLMECSSSGSPTPRSSWQKDGQPLLEDERHKFLSSGRILQVLNSQITDIGR YVCVAENTAGSAKKYFNFNVHVPPSVIGPNPENLTVVVNNFISLTCEVSGFPPPDLSWLK NEQPIKLNTNALIVPGGRTLQIIRAKVSDGGEYTCVAINQAGESKKKVSLTVYVPPSIKD HGSESLSVVNVREGTSVSLECGSNAVPPPVITWYKNGRMLTESARLEILADGQMLRITKA EVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPENEVTVETVSNPVTLTCDATGIPP PSIAWLKNHRPIENSGSLEVHILSGGRKLQIARSQHSDSGNYTCIASNMEGKAQKHYILS IQVPPNVADAEIPSEVSVLLGENVELVCSANGIPTPLIQWLKDGKPIVNSETERIRVAVD GSTLNIYRALPSDMGKYTCVATNPAGEEDRIFNLNVYVPPAIRGNKEEAEKLMALVDTSI NIECRATGMPPPQINWLKNGLPLPLSSHIRLLSGGQVIRIVRAQAPDVAVYTCVASNRAG VDNKHFSLQVLVPPSLDNGMGTEEITIVKGSSTSMTCFTDGTPAPRMSWLRDGRPLGLDA HLSISSQGMVLQLIKAETEDSGRYTCIASNEAGEVSKHFILKVLEPPHINGSEEPMEMSV IVNNPLELTCMASGIPAPKITWMKDGRPLPQMDQMQTLGGGEVLRISSTQVEDTGRYTCL ASSPAGDDDKEYLVRVHVPPNIAGTGEPQDFTVLRNRQVTLECKSDAVPPPVITWLKNGE RLQATPRIRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPSIKSGPQ SLVIHLNKSTLLECFAEGVPAPRITWRKDGAVLSGSHARYSVLENGFLRIQSAQVTDGGR YLCMATSAAGTDRRRIDLQVHVPPSIAPGPTNISVTVNVQTTLACEATGIPKPSVNWRKN GHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNDAGEDKRTVDLTVQVPPSIA DEPTDFLVTKHTPTVITCTASGVPFPSIHWMKNGVRLLPRGEGYRILSSGAIEILDTQLS HAGRYTCVARNSAGSAHRHVSLHVQEPPVIQPQPSELDVILNNPILLPCEATGTPSPFIT WQKEGISVISSGRSHAVLPRGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPV ISPHPKEYITVVDKPIMLPCKADGLPPPDIMWHKDGHVIVESVRQRILSSGALQIAFAQP GDAGQYTCTAANVAGSSSTSTKLTVRVPPRIQSTEVHYTVNENSQAVLPCVADGIPTPAI NWKKDNVPLANLLGKYTVEPYGELILENVVLEDSGTYTCIANNAAGEDTHTISLTVHVLP TFTELPGDVSLNKGEQLRLNCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERISK EDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPAPT IQWSRRGIDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPP IITLEPVETIINAGSKVILNCQATGEPRPTITWSRQGHSILWDERINVLSNNSLHIAAAQ KEDTSEYECVARNLMGSVLVRVPVIVQVPGGFSQWSAWRPCSATCGKGIQKRSRLCNNPS PANGGKPCQGSDSEMQNCHQKPCPVDGNWSEWSPWEECTRSCGRGNRTRTRTCNNPSAQH GGRPCEGTAVEIIMCNIRPCPVHGAWSTWQPWGTCSVSCGKGTQTRARLCNNPPPSFAGS YCDGAETQIQVCNERHCPIDGKWATWTSWSACSVSCGGGARQRTRDCSDPAPQYGGNKCE GSDVQSDFCNSDSCPTHGNWSPWSGWGICSRTCNGGQMRRYRTCDNPRPSNGGRACGGPD SQIQRCNTDMCPVDGSWGNWHSWSWCSTSCGGGEKTRKRLCNNPIPSKSGRPCPGDATQV SRCNIQVCPGGPQRARGSVIGSINDVEFGIAFLNATVTDSPNSDTRIIHAKITNVPRSLG PAMRKIVSILNPIYWTTAKEIGEAVNGFTLTNAVFKRETQVEFATGEILRMTHVARGLDS DGALLVDIIVSGYVLQLQSPAEVTMKDYTEDYVQTGPGQLYAYSTRLFTIDGVSVPYTWT HTVLYDEAQGRMPFLVETLHASSVESDYNQLEETLGFKIHASISKGERSNQCPPGFALDS VGPFCADEDECAAGNPCSHSCHNAMGTYYCSCPKGLTIAADGRTCQDIDECALGGYTCHA GQDCDNTIGSYRCVVHCGIGFRRTSDGLSCQDINECQESSPCHHRCFNAIGSFHCGCEPG YQLKGRKCVDINECRQNVCRPDQHCKNTRGGYKCIDLCPNGMTKAENGTCIDVDECKDGT HQCRYNQICENTRGSYRCVCPRGYRSQGLGRPCLDINECEQVPKPCAYQCFNTPGSFKCI CPPGQHLLGDGKSCAGLERLPNYGNQYSSYNLARFSPMRNNYQPQQHYRQYSHLYSSYSE YRNSRTSLSRTRRTIRKTCPEGSEASLDTCVDINECENTDTCQHECKNTFGSYQCICPPG YQLMLNGKTCQDIDECLEQNVRCGPNRMCFNMRGSYRCIETPCPPDYQRDPVSGFCLKNC PPNDLECALSPYALEYKLVSLPFGIAANQDLIRLVAYTQDGVMHPRTTFLMIDEEQTVPF ALRDENLKGVVYTIRPLQEPETYRMRVRALSYGANGTVEYQTTFIVYIAVSAYPY NT seq 16908 nt NT seq  +upstreamnt  +downstreamnt atgatttcctgggacatgatccacaccatattcttgctcgctcttctttatccttcccga gcgcaggatgcaatcccccagtccgaggtcgaggcagaagaaattcccgagggggcctca accttggcttttgtgtttgatgtgactggttccatgtatgatgatctagttcaggtgatc gagggggcttccaaaattttggagacgtctttgaaaagacctaagagacctctattcaac tttgctttggtgcctttccacgacccagagattggcccagtaacagttaccacagatccc aagaaatttcaatatgagctcagagaactctatgttcagggtggtggtgactgtccagaa atgagtattggagctataaaaattgccttggaaatttcccttcctgggtctttcatctat gttttcactgatgcgcgatccaaggattatcgactcactcatgaggtgctgcagcttatc cagcagaaacagtcacaggtggtatttgtgcttactggagattgtgatgacagaagccat attggatacagagtctatgaagaaattgcctctacaagttctggtcaagtgttccatctg gacaaaaaacaagttaatgaggttttaaaatgggtggaagaagcagtacaggcttccaaa gttcacctcttatcaacagaccatttggaacaggctgaaaatacttggaaaattcccttt gatcccagtctaaaagaggttactgtgtctctgagtggcccttctccaatgattgaaatt cacaatcctttaggaaagctgataaaaaagggatttggcctgaatgagctattaaatatt cataactctgccaaggtggtgaatgttaaagagccagaggctggaatatggacagtgaag acatctagcactggaaggcactctgttcgcatcactggcctcagtactattgattttcga gctggtttttcccgaaagcccaccctggacttcaaaaaaacagtcagcagaccggtgcaa ggaatacctacctatgtgctgctgaatacttctggaatttccatcccagctaaagtagat cgtcttgaacttctgagtatctcaggcagttctcttaagactattcctgttaaatattat cctgatagaaaaccctatggcatatggaatatttctgattttataccaccaaatgaagct ttctttctcaaagtaacaggctatgataaggatgattttctcttccagagagtgtcaagt gtttctttctctagtattgtgccagatgctccgaaagttacaatgcctgagaaaaccccg ggctactacctgcagccgggccagattccctgcgctgttgacagtcttctgccttttacc ttgagttttgtcagaaatggagctacacttggagtcgaccagtatttaaaagaatctgcc agcgtgacctgggatattgaagaggtcactctggctgacgaaggcgcctatgagtgcgtt gctgtcagtactgcagggattggacgagcacagacgttcttcgacgtgtcagagcccccg ccagtcatccaagtgcctagtaatgttaccgtcactcctggagaaacagcagttctgaca tgccttgtcgtcagtgcagtgggttacaatctaacctggcagaggaatgaccgagatatc aggctgacagatacagcaggaatgaggatcttggctaacctttccctggagctcaggagt gtgaaattcagcgatgcaggagagtatcgctgtgttgtttccaacgaaggaggatcatcg actgaggctgttttcctcaccgtgcaagaaccgcccaaagtcactgtgatgcctaagaat cagtccttcacagctggatctgaggtctccatcatgtgttctgcaacaggttatcccaaa ccaaagatcgcctggaccgtgaatgatgtgtttatcatgggttcacacaggtataggatg acctcagaaggtaacttatttatcaaaaatgcagttcccaaagatgcagggatctatggt tgcctggcaagtaattcagctggaatggataaacagacttctaccctcagatacattgaa gccccgaagttgattgtagttcagagtgagctcttggttgccctgggagatacaacagtt atggaatgtaaaacctctggtgttcctccacctcaagttaaatggttcaaaggggatctt gagctgaagccctcaacattcctcattattgaccctctcttgggacttttgaagattcaa gaaactcaagatttggatgctggtgattatacgtgtgttgctgtcaatgatgctggaaga gcaactggcaggataactctggatgttggctcacctccagtttttatacaagaacctact gatgtatctgtggagattggctcaaatgtgacattaccttgctatgtccagggttatcca gaaccaaagattaaatggcgaagagtagacaacatgcccatcttctcaagacctttttca gtgagttccatcagccaactaagaacaggagatctctttatttcaaacttatgggcaagt gataaaggaacatacatttgtgaagcagaaaaccagtttggaaagatccagtcccagaca acagtaacagtgacaggacttgtcgctccactcattggaatcagccccccagtgaccagt gtaattgaaggacagcagcttactttgccttgtgctctactggctggaaatcctattcca gaacgtcggtggattaagaattcagccatgttggtccaaaacccttacatcactgtacgc agtgacgggagtctccatattgaaagagtccgcttgcaggatggaggcgagtatacttgt gtggccagtaatgttgccggaaccaccaacaaaaccaccactgtggacgtgcatgttctg ccaaccattcagcatggacagcagatcctcagtaccatcgaaggcattccagtaacttta ccgtgcaaagcaagtggaattcccaaaccatctattgcctggtccaagaagggcgagctg atttccagcagcaatgctaagttttccgcaggggctgatgggagtctgtacgtggtgtcc cctgggggtgaggagagcggggagtatgtgtgcaccgccaccaatgcagctggctacgcc aaaaggaaagtgcagctgactgtctatgtaaggcccagggtgttcggagaccaaagggga ccatcccaggataagcctgttgagatctcagtctttgcgggagaagaggtgacccttccg tgtgaagtgaagggtttacccccacccatcattacttgggccaaagaaacccagctcatt tctccattctctccaagacacacgttcctcccttctggttcaatgaagatcactgagacc cgtgtttcagatagtgggatgtatctttgcgtcgccacaaatattgcagggaatgtgacc cagtctgttaaattaaacgtccatgtgcctccaaagatacagcgtggccctaaagttatg aaagtccaagttggtcaaagagtggacattccgtgcagtgctcaagggacacctcttcct gttatcacctggttcaaaggtggaggcgccgtgctggttgatggactgcagcacattagg catccagatgggacattaagcatcaaacaagcggtgctctcagatgctggcatatataca tgtgtcgctactaacatagcaggcagtgatgagacggagataacactacatgttcaagaa ccacctattctggaagacctagagcctccatataacactccattccaagagagagtggcc aaccaacgcattgcatttccatgtcctgcaaaaggtacccccaaaccaaccatcaaatgg ttgcggaatggtagagagctgacaggccaagagcctggtatttctatattagaagacggc acattgttggttattgcttctgttacaccatatgacaacggggagtatatttgtgtggca gtcaatgaagctggaaccacagaaagaagatataatctcaaagtccatgttcctccagta attaaagataaagaacaagtaacaaatgtgtccgtgttggtcaaccagccaaccagtctc ttttgtgaagttgaaggtactccatctcccatcattatgtggtataaagatgatgttcag gtgactgagagcagcagtattcagattgtaaacaatgggaagatattaaagctcttcaga acctctccagaggatgcaggaagatattcctgtaaagcaattaatgttgcaggcacttct caaaagcattttaacattgatgtgctagtcccgcccaccataataggtgctggttcccct ggtgaagtctcagttgtcctgaaccagaataccacccttgaatgccgggtgaaaggcacc ccctttcctgttattcgctggttaaaagatggcaagcctttatttttgggagaccctaat attgaaattctagacagaggacaagttttacatttaaagaatgcacgaagaagtgacaag ggacgctaccagtgttctgtgtccaatgcagctggcaaacaagccaaggatataaaactg acaatctatattccacctagtattaaaggagggaatgtcaccacagaagtgtcagctttg atcaacagcataattaaactggaatgtgaaacacgaggacttccgatgcctgctattact tggtataaggatggccagccagtcatatccagctcacaagcactttatgttgaaaaagga caatttcttcatattcctcgagcacaggtctctgattcagcagcatataagtgtctagta accaatgttgctggaactgctgaaaaatcattccatgtggacgtctatgttcctccagtg attgaaggtgacctggctgagcctctgaataagcaagtgaaagttgctcattcactgacc ctggagtgtaaagctgccggcaaccctcctccagttttaacctggttgaaagatggtgta cctgtgaaagccagtgacaacatccgcatagaagctggtgggaagaaactagaaatcaca agtgccctagaagtcgataggggacagtatatatgtgtggctacgagtgtggcaggagaa aaggaaatcaaatacgaagttgatgtcttagtgccaccagctatagaaggaggagatgaa acgtcttacttcattgtaatggtcaataacttgctggaactagattgtcaagtgacaggt tctcctccaccaactatcatgtggctgaaggatggccagctcattgatgaaagagatgga ttcaggatcttactaaatggacacaaactggttattgcccaggctcaagtgtcagacaca ggcctttatcggtgtgtagcaacaaacactgctggagaccacaggaaggaatttgaagta actgttcatgttcctccaacaatcaaaccctcaggtctttctgagagagctgtactgaag tacaagcccatcaccttgcagtgcacagctaatggcgttccgaatccctctattacatgg ttgaaagatggacagcctgtcaacactgcccaagggaacctcaaaatacagtcttctggt cgacttctacaaattgccaaagccctgatggaagatgctggcagatacacgtgtgtggct accaatgcagctggagaaacacagcagcacattcaactgcatgtacatgagccacccagc ctggacgatgcagggaagatgctgaatgagaccgtggtggtgaacagccccgtgcagctg gagtgtaaggcagctggaactccctcacctgctattacatggtacaaagataatcgtcca ctatcagattccagtagtgtgactttcttgaacagaggacagatcatcaatattgaaagt gcccagatcacagatgctggcatatataaatgtgtggccatcaactcagctggagcaacc gagctgttttacagtctgcaggtccatgtgcccccatcaatttttggcagcaataacatg gtggcagtggtggttaataacctggtgaggttagagtgtgaagccagaggtatcccagcc ccaagtctgacctggctgaaagatgggagccccgtcacgagtttcgttaatgggatacag gttctgtctgggggccgcatcctagcattgaccagcgcacagatcagtgataccgggaga tacacctgcgtggcagtaaatgctgccggggagaaacaaagggacattgacctcagagta tatgttgcaccaaatattatgggagaagaacagaacgtctctgtcctcattagccaagct gtggagttactatgtcaaagtgatgctattcccccaccgactctgacctggttaaaagat ggccaccccttgctgaagaaaccaggtctcagtgttactgaaaatgggagtgtgctaaag attgaagatgctcaggttcaagatagtggtcgctacacttgtgaagccacaaatgttgca ggaaaaactgagaagaactataatgtcaacatttgggtaccgccaaatatttctggttct gatgaagctgctcaacttacggtcattgaaggacacctcattagtctattgtgtgaatca agtggtattcctcccccaaatctcatttggaagaagaaaggctccccagtgctggctgat tctgcagggcgagtcagaattttatctggaggcaggcagctgcagatttcaattgcagaa aaatctgatgcagggctctattcatgtatggcatcgaatgttgctgggactgcaaagaaa gactacagtctgcaagtttacattcgaccaactatatccaacagtggtagccaccctact gaaatcattgtaactcgaggaaagagcgtttccttggagtgtgaggtggaaggtgttcct cagccagcagtgacctggatgaaagatggccgccctttgacaaagggaagaggaatggaa ataatggatgaaggtcgtatggttcagctgaagaatgttcatgtgtctgacacaggccgt tatatgtgtgttgctatgaatatagcaggaatgactgacagaaaatatgacttaagtgta cacacccctccaagcatcattggaaaccacaggacacctgaaaatataagtgtggtggaa aaaagctcagtgtcgctaaattgtgaagcttcaggaattcccctgccttcaattacgtgg cttaaagatgggtggcccgtcaaccttagcagctccctgcgaatcctctcaggaggtagg attctgcgattgatgcagaccagaacagaagatgctggccagtatacatgtgttgtaaga aacgcagctggtgaagaaagaaaaatcttccggctttcagtattagtaccacctcacatc atgggtgaaaatacatttgaagatgtgaaagtaaaagagaagcagagtgttacactgact tgtgaagtgacagggaatccagtaccagaaataacatggcataaagatggtcagctcctg aaagaagatgacactcatcatcttatgtctgatggccgttttcttcaaattgtgaatgcc caagtgtcacacaccggaagatacacatgtttggcgtctaatacagctggtgacaagagc aaaagtttcagtcttaatgtgttggtatctcctataattgctggtgttgatggtgatggc agccctgaagacatcactgttatccttaacagccccacatctttggtctgcgaagcttat tcatatcccccagccaccatcacctggtttaagaatggaactcctttagaatccaaccaa aatatccgtattcttccaggaggcaggactctgcagatcctaaatgcacaggaggacgat gctgggagatacgcttgtgtagccactaatgaggcaggggagatgataaagcattatgaa gtgaaggtctacattccacccataatcaataaaggggacctcctggggccaggtctttcc cctagagaagtgaagatcaaagtaaacaacacactgaccttggagtgtgaagcctatgca attccttctgcatctctcagctggtacaaggatggacagccccttaaatcagatgatcat gttaccattgctgcgggtggacacacacttcaaatcaaggaggctcaaatatcggacact ggacgatacacgtgtgtggcatctaatgttgcaggtgaagatgagctggattttgatgtg aatatacaagttcctccaagtttccagaagctctgggaaataggaaacagggtggatact ggcaggagaggtgaagccaaggacgtgatcatcaacaatcccatctctctctattgtgag actaacgctgctcccgcgcctacactgacgtggtataaagatggccaccctctcacctca agtgagagagtactgattttgccaggagggcgagtgttacaaattcctcgggctaaagta gaagatgctgggagatacatgtgtgtggctgtgaacgaggctggagaagattcccttcag tatgacgttcgtgtactcttgccaccagttatcaagggagcaaatggtgatctccctgaa gaggtcaccgtgctggtgaacaagagtgtgctgatggagtgttcatccagtggcagtccc acaccacggagttcctggcaaaaagatgggcagcccttgctagaagatgagcgtcataaa tttctatctagtgggagaattcttcaggttctaaatagtcaaataacagatatcggcaga tatgtgtgcgttgctgagaacacagctggaagtgccaaaaaatattttaacttcaatgtt catgttcctccaagtgtcattggtcctaaccctgaaaatctcactgttgtggtgaacaat ttcatctctttgacctgtgaggtctctggttttccacctcctgatctcagctggctcaag aatgaacagcctatcaaactaaacacaaatgctctcattgtgcctggtggtcgaactttg caaattatccgggccaaggtatctgatggtggtgaatacacttgtgtagctatcaaccaa gctggggaaagcaagaaaaaagtttccctgactgtttatgtgcccccaagcattaaagat catggaagcgaatctctttctgtagttaatgtaagagaggggacctcagtatcactggag tgtggatcgaatgctgtcccgcctccagtcatcacctggtataagaatggacggatgcta acagagtctgctcggctggagattttggccgatggacaaatgctgcgcatcacaaaagct gaggtatctgacacaggccagtatgtatgtagagctataaatgtagcaggacgggatgat aaaaatttccacctcaatgtatatgtgccacccagtattgaagggcctgaaaatgaagtc actgtggagacagtcagcaatcctgttactttaacatgtgatgctactggaatcccacct ccctccatagcatggttgaagaaccacagacccatagaaaattctggctcactggaagtt catattttgtctgggggaagaaaactccaaattgccaggtcccaacattcagatagtgga aactatacatgcattgcctcaaatatggaggggaaagcacagaaacattacattctttca attcaagttcctccaaatgttgctgatgctgagattccaagtgaagtcagtgtccttctt ggggaaaatgttgagctggtctgcagtgcaaatggcattcccaccccacttattcagtgg cttaaagatggaaagcccatagttaacagtgaaacagaaagaattcgggtggctgtagac ggcagcacattaaacatttacagagctctcccatctgacatggggaagtacacgtgtgtt gctactaatcctgctggagaagaagaccggatttttaatttaaatgtctatgttccacct gcaattaggggtaataaagaagaagcagagaaattaatggctttggtggatacctcaata aatattgaatgcagagccacaggaatgcctccaccacagataaactggctaaagaatgga cttcctctgcctctctcctcccatatccggttgctgtctggaggacaagttatcaggatt gtgagagctcaggcacccgatgtcgctgtgtatacttgtgtggcatccaacagagctggg gtggataataaacatttcagccttcaagttttggtaccaccaagtctggacaatgggatg gggacagaggaaatcacaattgtcaagggtagttccacctccatgacatgttttactgat ggaaccccagctcccaggatgtcctggcttagagatggtcggcctctggggctagatgcc catctgtcaatcagctctcaaggaatggtccttcagctcatcaaagcagaaactgaagat tcgggacggtacacctgcattgcctcgaatgaagcaggagaagtcagcaaacactttatc ctgaaggtcttggaaccacctcatatcaatggatctgaagaacccatggagatgtcagta attgttaataatcctcttgaacttacctgcatggcttctggaatcccagctcctaagatt acctggatgaaagatggtcgaccccttccacagatggatcagatgcagactcttggagga ggagaggttcttcgaatatctagtactcaggtggaagatacaggaagatacacatgtctg gcatccagtcctgcaggagatgatgataaagagtatttagtgagagtgcatgtaccccct aatattgctggaactggcgagccccaggatttcactgtgttacggaacagacaagtgaca ctggaatgcaaatcggatgcagtgcctccacctgtaatcacttggcttaaaaatggagaa cggttacaggcaacacctcgaataagaatcctatctggagggagatatttgcaaattaat aatgcagatctaggtgatacagccaattatacctgtgttgccagcaacattgcgggaaag actacaagagagtttattctcactgtcaatgttcctccaagcataaagagtggcccccag agtcttgtcattcacttaaataagtcaactctattggaatgctttgcggaaggcgtgcca gccccaaggataacatggagaaaggatggagctgttctatctggtagtcatgcaagatac tccgtcttggaaaatggattccttcgcatccagtcagcacaagtgactgacggtgggcga tatttgtgtatggccaccagtgccgcggggacagaccgcaggcgaatcgatttacaggtc cacgttcctccatccattgctccgggtcctaccaacatatctgtaacagtaaatgttcaa accactctggcttgtgaggctactggcataccgaaaccgtcagtcaactggaggaaaaac gggcatcttctgaatgtggatcaaaatcagaattcatacaggctcctttcttcaggttca ctggtaattatttccccttctgtggacgacactgcgacctatgagtgcacggtaaccaat gatgccggagaggacaagagaactgtggatctcactgtccaagttccaccttccattgct gatgagcctacagacttcctagtaaccaaacacacccccacagtgatcacctgcaccgct tcaggagttccgtttccctcaatccactggatgaagaatggtgtaagactgcttcccaga ggagagggttatagaattctgtcctcaggagcaattgaaatacttgacactcaactaagc catgctggaagatatacttgtgttgccaggaattcagctggttctgcacatcgacatgta agccttcatgtccaagagcctccagtcattcagcctcagccaagtgagctggacgtcatt ctaaacaatcccattttattaccctgtgaagcaacagggacacccagtcctttcatcact tggcaaaaagaaggcatcagtgtcatcagttcaggtagaagccatgcagttcttccccgt ggcggcttgcagatctccagagctgtcagagaggatgctggtacttacatgtgtgtggct cagaatccagctggtacagccttgggcaaaatcaagttgaatgtccaagttcctccagtc attagccctcatcctaaggaatacatcactgttgtggataagcccatcatgctaccctgt aaggcagatggcctcccaccacctgacatcatgtggcataaagatgggcatgtaattgtg gagtcagtccgccagcgcatcctcagctccggtgctctgcagatagcatttgctcagcct ggtgacgcgggtcagtacacgtgcacggcagctaacgtggcaggatcaagcagcacgagc accaagctcaccgtccgtgtaccacctagaatccaaagtacagaagtacattacacggtc aatgagaattcacaagccgttcttccatgcgtggctgatggaatccccacaccagcaatt aactggaaaaaagacaatgttcctttggctaacttgttaggaaaatacactgttgaaccc tatggagagcttatcctggaaaatgttgtgctggaggattctggcacctatacctgcatt gctaacaatgccgcaggtgaagacacacacaccatcagcctgactgttcatgttcttccc acttttactgaactccctggagatgtgtcattaaataagggagaacagctccgtttaaac tgtaaagcaactggtatcccattgcccaagttaacatggacgttcaataacaatattatc ccagcccactttgacagcgtcaatggacacagtgaacttgttattgaaaggatatcaaaa gaggattcaggcacttatgtgtgcactgccgaaaacagcgttggtttcgtgaaggcaatc ggatttgtttatgtgaaagaacctccagtcttcaaaggtgattacccttctaactggatt gaaccacttggtggtaatgcaatcctgaattgtgaggtgaaaggagatcccgccccaacc atccagtggagcagaagggggatcgatattgaaattagccacagaatccggcaacttggc aatggctccttggccatttatggcactgtaaatgaagatgctggtgattatacatgtgta gctaccaacgaagctggggtggtggaacgcagcatgagtctgactttgcagagtcctcct attatcactcttgaaccagtagaaactattattaatgctggcagcaaagtcatcttgaat tgtcaagcaactggagagcctcgtccaaccattacatggtcccgtcaagggcactctatc ctctgggatgagagaattaatgtgttgtccaataactcattacatattgctgctgctcag aaagaagatacgtctgagtatgaatgcgttgctcgaaacttgatgggttctgtccttgtg agagtgcctgtcatagtccaggtgcctggtggcttttcccagtggtcggcctggagaccc tgcagtgccacctgtggaaaagggatccagaagaggagtcgtctgtgcaacaacccctct ccagccaacggggggaagccttgccagggatcagattcagaaatgcaaaactgtcaccag aagccatgtccagtggacgggaactggtcagaatggagtccctgggaagaatgcacgagg agctgtggacgcggcaaccgaaccaggaccagaacttgcaataatccatcagctcaacac ggtgggcggccgtgtgaagggactgccgtggaaatcatcatgtgcaacattcggccttgc ccagttcatggagcatggagtacctggcagccttgggggacatgcagcgtaagttgtggg aaaggtacccaaacaagagcaagactgtgcaataacccaccaccgtcattcgctgggtcc tactgtgatggagcagaaacacagattcaagtttgcaatgaaagacactgtccaattgat ggcaagtgggccacctggaccagttggagtgcctgctctgtatcctgtggaggcggcgcc aggcagagaacaagggactgctctgatcctgctccccagtatggaggcaacaaatgtgaa gggagtgatgtccagagcgatttttgtaatagtgactcttgtccaactcatggtaactgg agtccttggagtggctggggaatatgcagccggacatgtaatggggggcagatgcggcgg taccgcacatgtgataaccctcgtccctccaatggaggaagagcttgtgggggcccagac tcccagatccagagatgcaacacggacatgtgtcctgtggatggaagttggggaaactgg catagttggagctggtgttccacctcttgtggaggaggtgaaaagacacgaaaacggctg tgcaacaatccaataccatctaaaagtggtcgcccctgcccaggcgatgctactcaggta tccagatgtaatatacaagtatgtccaggtgggccccagcgagccagaggaagtgttatt ggaagcattaatgatgttgaatttggaattgctttccttaacgccacggtcacagatagc ccaaactctgatactagaataatacatgccaaaattaccaatgtacctcgcagtctcggt ccagcaatgagaaagatagtttctattctaaatcccatttattggacaacagcaaaagaa ataggagaagcagtcaatggctttaccctcaccaatgcagttttcaagagagaaacccaa gtggaatttgcaactggagaaatcttgcggatgactcacgttgcccggggcttggattct gatggtgctctgctggtagatatcattgtgagtggctatgtcctgcagctacagtcacct gccgaagtcaccatgaaggattacaccgaggactatgttcagacaggccctgggcagctg tatgcctactcaacccggctgttcaccattgacggcgtcagcgtgccttatacatggacc cacaccgtcctctacgacgaggcacagggaagaatgcctttcttggtagaaacacttcat gcatcctctgtggaatctgactacaaccagttagaagagacactgggttttaaaatccac gcttcaatttccaaaggagaacgcagtaatcagtgtccccctgggtttgccttagactcg gttggacccttttgtgctgatgaagatgaatgtgccgcaggaaatccctgctctcattcc tgtcacaatgccatgggaacctattattgctcctgccctaaaggcctcaccatagctgcc gatggaagaacttgtcaagatattgatgagtgtgctttgggtggctacacctgccatgct ggtcaggactgtgataataccatcggatcctatcgctgtgtagtccactgtggaattggc tttcgaagaaccagtgatggcctgagttgtcaagatattaatgaatgtcaagaatccagc ccctgtcaccaccgctgtttcaatgccataggaagttttcactgtggatgtgaacctggg tatcagctcaaaggcagaaaatgtgtggatataaatgagtgtagacagaatgtatgcaga ccagatcagcattgcaagaacactcgcggtggttataaatgcattgatctctgtccaaac ggaatgaccaaggcagaaaatggaacctgcattgatgttgatgagtgtaaagatgggacc catcagtgcagatataaccagatatgtgagaatacaagaggcagctatcgttgtgtgtgt ccaagagggtaccggtctcaaggacttggaagaccctgtttggatattaatgaatgtgaa caagtgcctaagccttgtgcatatcagtgcttcaacacccctggcagcttcaagtgtatc tgtccaccaggacaacatttgttaggggacgggaaatcttgcgctggactggagaggctg ccaaattatggcaatcaatacagtagctataaccttgcacgcttctcccccatgagaaac aactatcaacctcaacagcattacagacagtactcacatctctacagctcctactcagag tataggaacagcagaacatctctctccaggactagaaggactattaggaaaacttgcccc gaaggctctgaggcgagccttgacacatgtgtagatattaatgaatgtgaaaatacagac acctgtcagcatgagtgtaaaaatacctttgggagctatcagtgtatctgtccacctggc tatcagctcatgctcaatggaaagacatgtcaagatattgatgagtgtctggaacagaat gtgcgctgtgggccgaatcgcatgtgcttcaacatgagaggaagctaccgttgcattgag acaccctgtccacctgactaccaacgggatcctgtgtcagggttctgtctcaagaactgt ccacccaatgatttggaatgtgccttgagtccatatgccttggaatacaaactcgtctcc ctcccgtttggaatagctgccaatcaagatttgatccggctggttgcatacactcaagat ggagtgatgcatcccaggacaactttcctcatgatagatgaggaacagactgttcccttt gccttaagggatgaaaacctgaaaggagtggtgtacacaatacgaccactacaggaacca gagacctaccgcatgcgggttcgagccttatcctacggtgccaatgggaccgttgagtat cagaccacattcatagtttatatagctgtgtctgcctatccgtactaa

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