Bison bison bison (American bison): 105001683 Help Entry 105001683         CDS       T08726                                  Symbol ADCY6 Name (RefSeq) adenylate cyclase type 6   KO K08046   adenylate cyclase 6 [EC:4.6.1.1] Organism bbis  Bison bison bison (American bison) Pathway bbis00230   Purine metabolism bbis01100   Metabolic pathways bbis01522   Endocrine resistance bbis04015   Rap1 signaling pathway bbis04022   cGMP-PKG signaling pathway bbis04024   cAMP signaling pathway bbis04062   Chemokine signaling pathway bbis04072   Phospholipase D signaling pathway bbis04081   Hormone signaling bbis04082   Neuroactive ligand signaling bbis04114   Oocyte meiosis bbis04211   Longevity regulating pathway bbis04213   Longevity regulating pathway - multiple species bbis04261   Adrenergic signaling in cardiomyocytes bbis04270   Vascular smooth muscle contraction bbis04371   Apelin signaling pathway bbis04540   Gap junction bbis04611   Platelet activation bbis04713   Circadian entrainment bbis04714   Thermogenesis bbis04723   Retrograde endocannabinoid signaling bbis04724   Glutamatergic synapse bbis04725   Cholinergic synapse bbis04727   GABAergic synapse bbis04742   Taste transduction bbis04750   Inflammatory mediator regulation of TRP channels bbis04911   Insulin secretion bbis04912   GnRH signaling pathway bbis04913   Ovarian steroidogenesis bbis04914   Progesterone-mediated oocyte maturation bbis04915   Estrogen signaling pathway bbis04916   Melanogenesis bbis04918   Thyroid hormone synthesis bbis04921   Oxytocin signaling pathway bbis04923   Regulation of lipolysis in adipocytes bbis04924   Renin secretion bbis04925   Aldosterone synthesis and secretion bbis04926   Relaxin signaling pathway bbis04927   Cortisol synthesis and secretion bbis04928   Parathyroid hormone synthesis, secretion and action bbis04934   Cushing syndrome bbis04935   Growth hormone synthesis, secretion and action bbis04961   Endocrine and other factor-regulated calcium reabsorption bbis04962   Vasopressin-regulated water reabsorption bbis04970   Salivary secretion bbis04971   Gastric acid secretion bbis04972   Pancreatic secretion bbis04976   Bile secretion bbis05032   Morphine addiction bbis05163   Human cytomegalovirus infection bbis05166   Human T-cell leukemia virus 1 infection bbis05200   Pathways in cancer bbis05207   Chemical carcinogenesis - receptor activation bbis05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:bbis00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     105001683 (ADCY6)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     105001683 (ADCY6)    04371 Apelin signaling pathway     105001683 (ADCY6)    04072 Phospholipase D signaling pathway     105001683 (ADCY6)    04024 cAMP signaling pathway     105001683 (ADCY6)    04022 cGMP-PKG signaling pathway     105001683 (ADCY6)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     105001683 (ADCY6)    04081 Hormone signaling     105001683 (ADCY6)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     105001683 (ADCY6)   09144 Cellular community - eukaryotes    04540 Gap junction     105001683 (ADCY6)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     105001683 (ADCY6)    04062 Chemokine signaling pathway     105001683 (ADCY6)   09152 Endocrine system    04911 Insulin secretion     105001683 (ADCY6)    04923 Regulation of lipolysis in adipocytes     105001683 (ADCY6)    04912 GnRH signaling pathway     105001683 (ADCY6)    04913 Ovarian steroidogenesis     105001683 (ADCY6)    04915 Estrogen signaling pathway     105001683 (ADCY6)    04914 Progesterone-mediated oocyte maturation     105001683 (ADCY6)    04921 Oxytocin signaling pathway     105001683 (ADCY6)    04926 Relaxin signaling pathway     105001683 (ADCY6)    04935 Growth hormone synthesis, secretion and action     105001683 (ADCY6)    04918 Thyroid hormone synthesis     105001683 (ADCY6)    04928 Parathyroid hormone synthesis, secretion and action     105001683 (ADCY6)    04916 Melanogenesis     105001683 (ADCY6)    04924 Renin secretion     105001683 (ADCY6)    04925 Aldosterone synthesis and secretion     105001683 (ADCY6)    04927 Cortisol synthesis and secretion     105001683 (ADCY6)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     105001683 (ADCY6)    04270 Vascular smooth muscle contraction     105001683 (ADCY6)   09154 Digestive system    04970 Salivary secretion     105001683 (ADCY6)    04971 Gastric acid secretion     105001683 (ADCY6)    04972 Pancreatic secretion     105001683 (ADCY6)    04976 Bile secretion     105001683 (ADCY6)   09155 Excretory system    04962 Vasopressin-regulated water reabsorption     105001683 (ADCY6)    04961 Endocrine and other factor-regulated calcium reabsorption     105001683 (ADCY6)   09156 Nervous system    04724 Glutamatergic synapse     105001683 (ADCY6)    04727 GABAergic synapse     105001683 (ADCY6)    04725 Cholinergic synapse     105001683 (ADCY6)    04723 Retrograde endocannabinoid signaling     105001683 (ADCY6)   09157 Sensory system    04742 Taste transduction     105001683 (ADCY6)    04750 Inflammatory mediator regulation of TRP channels     105001683 (ADCY6)   09149 Aging    04211 Longevity regulating pathway     105001683 (ADCY6)    04213 Longevity regulating pathway - multiple species     105001683 (ADCY6)   09159 Environmental adaptation    04713 Circadian entrainment     105001683 (ADCY6)    04714 Thermogenesis     105001683 (ADCY6)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     105001683 (ADCY6)    05207 Chemical carcinogenesis - receptor activation     105001683 (ADCY6)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     105001683 (ADCY6)    05163 Human cytomegalovirus infection     105001683 (ADCY6)   09165 Substance dependence    05032 Morphine addiction     105001683 (ADCY6)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     105001683 (ADCY6)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     105001683 (ADCY6)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     105001683 (ADCY6) Enzymes [BR:bbis01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      105001683 (ADCY6) SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc AC_N Adcy_cons_dom HNOBA TBK1_ULD GBR2_CC Motif Other DBs NCBI-GeneID:  105001683 NCBI-ProteinID:  XP_010856363 Ensembl:  ENSBBBG00000006325 UniProt:  A0A6P3IPY4 LinkDB All DBs Position Unknown AA seq 1084 aa AA seqDB search MCISVWAGAGERLPRESGATWMSWFSGLLVPKVDERKTAWGERNGQQRPRRGTRTSGFCT PRYMSCLQGAQPPSPTPATAPRCPWQDEAFIRRGGPGKGPELGLRAVALGFEDPEVAGAV GAAEVAPAVATRSRRACWRQLVQVFQSKQFRSAKLERLYHFVYITYTLLPIRMRAAVFSG LGLSTLHLVLAWQLNRGDAFLWKQLGANMLLFLCTNVIGICTHYPAEVSQRQAFQETRGY IQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFAD IEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHA HCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANH MEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQHIETFLILGASQKRKEEKA MLAKLQRARANSMEGLMPRWVPDRAFSRTKDSKAFRQMGIDDSSKDNRGAQDALNPEDEV DEFLGRAIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFIC FIQLVVFPRSALMLGIHASIFLLLLVTVLTCAVYSCGSLFPEALQRVSRSIVRSRAHSTA VGIFSVLLVFTSAVASMFTCNHTPLRTCAARMLNLTPADITACHLQQLNYSLGLDAPLCE GTAPTCSFPEYFIGNVLLSLLASSVFLHISSIGKLAMIFVLGLVYLVLLLLGPPATIFDN YDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPVILLVFALALYLHAQQVESTARLDF LWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFAS IANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLN ASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQY DIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLNG GPRS NT seq 3255 nt NT seq  +upstreamnt  +downstreamnt atgtgtatctccgtatgggcaggtgctggggagcggcttcccagagaaagtggggccacg tggatgtcatggtttagcggcctcttggtccccaaggtggatgaacggaaaacagcctgg ggggagcgcaatgggcagcagcggccgcgccgtgggacccgcaccagtggcttctgcacg ccccgctacatgagctgcctccagggtgcgcagccacccagtccgacgcccgccactgcc cctcggtgcccctggcaggatgaggccttcatccggagagggggcccaggcaagggcccg gagctggggctgcgggcggtggccctgggcttcgaggaccctgaggtggccggggccgtc ggagcagcggaggtggcgcctgccgtggccaccaggagcaggcgggcctgctggcgccag ctggtgcaggtgttccagtcgaagcagttccgctcggccaagctggagcgcctgtaccac tttgtctacatcacctacacactccttcccatccgcatgcgggctgcagtcttcagcggc ctgggcctctccaccctgcacttggtcttggcctggcagctcaaccgtggtgacgccttc ctctggaagcagcttggagccaacatgctgctgttcctctgcaccaatgtcattggcatc tgcacacactatccggctgaggtgtctcagcgccaggcatttcaagagacccgcggttac atccaggcccggctgcacctgcagcatgagaaccggcagcaggagcggctgctgctgtct gtgttgccccagcatgttgccatggagatgaaagaagacatcaacacaaagaaagaagac atgatgtttcataagatctacatccagaagcacgacaatgtcagcatcctgtttgcggac attgaaggcttcaccagcctggcatcccagtgcacagcgcaggagctggtcatgaccctg aacgagctctttgcccggttcgacaagctggctgcggaaaatcactgcctgaggatcaag atcttaggggactgttactactgcgtgtcggggctgccagaggcccgggcagaccatgcc cactgctgcgtggagatgggggtggacatgatcgaggctatctcgctggtgcgcgaggtg acaggtgtaaacgtgaacatgcgcgtgggcatccacagcgggcgtgtgcactgtggcgtc cttggcttgcggaaatggcagtttgatgtgtggtccaatgacgtgactctggccaaccac atggaggccgggggccgggccggccgcatccacatcacccgggccacgctgcagtacctg aatggggactacgaagtggagccgggccgcggtggggagcgcaacgcctacctcaaggag cagcacattgagaccttcctcatcctgggagccagccagaaacggaaagaagagaaggcc atgctggccaagctgcagcgggcacgggccaactccatggaagggctgatgccacgctgg gtgcctgaccgtgccttctcccggaccaaggactccaaggctttccgccagatgggcatc gatgattccagcaaagacaaccggggtgctcaggatgccctgaaccctgaggatgaggta gacgagttcctgggccgggccattgatgcccgcagcattgatcagctgcgcaaggaccat gtgcgccggttcctgctcaccttccagagagaggatcttgaaaagaagtactcacgcaag gtggacccccgctttggagcctacgtggcctgtgccctgctggtcttctgcttcatctgc ttcatccagcttgttgtcttcccacgctcagctctgatgcttgggatccacgccagtatc ttcctgctgttactggtcaccgtgctgacttgtgccgtgtactcctgtggctctctgttc cctgaggccctgcaacgtgtatctcgcagtatcgtccgctcgagggcacatagcaccgca gttggcatcttttctgtcctgcttgtgttcacctccgccgttgccagcatgttcacctgt aaccacacccccttacgaacttgcgcagcccggatgctgaatttaacccctgctgacatt accgcctgccacctgcagcagctcaattactctctgggcctggatgctcccctgtgtgag ggcaccgcacccacctgcagcttccctgagtacttcattgggaacgtgttgctgagtctc ttggccagctctgtcttcctgcacatcagtagtatcgggaagttggccatgatctttgtc ctggggctcgtttatctggtgctgcttctgctgggtcccccagccaccatctttgacaac tatgacctcctgctgggcgtccatggcttggcttcttccaatgagacctttgatgggctg gactgcccagcggccgggagggtggcactcaaatacatgacccccgtgattctgctggtg tttgcactggcgctgtacctgcatgcccagcaggtggagtccaccgcccgcctggacttc ctctggaagctgcaggcaacaggggagaaggaagagatggaggagctccaggcctacaac cggcggctgctacataacattctgcccaaggacgtggccgcccacttcctggcccgggag cgccggaacgacgagctctactatcagtcctgtgaatgtgtggccgtcatgtttgcctcc attgccaacttctctgagttctacgtggagctggaggccaacaacgagggtgttgagtgc ctgcgactgctcaatgagatcattgctgatttcgatgagatcatcagtgaggagcgcttc cggcagctggagaagatcaagacaattggtagcacctacatggctgcctctgggctgaac gccagcacctatgatcaggtgggccgctcccacatcactgccctcgccgactatgccatg cggctcatggagcagatgaagcacatcaatgagcactccttcaacaatttccagatgaag atcggactgaacatgggcccagttgtggcaggcgtcattggggctcggaagccacagtat gacatctgggggaacacagtgaatgtctcgagtcgaatggacagcactggggtccccgac cgaatccaggtgaccacggacctgtaccaggttctagcggccaagggctaccagctggaa tgtcgaggggtggtcaaggtgaagggcaagggggagatgaccacctacttcctcaatggg ggccccaggagttag

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