Bison bison bison (American bison): 105003134 Help Entry 105003134         CDS       T08726                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism bbis  Bison bison bison (American bison) Pathway bbis04020   Calcium signaling pathway bbis04024   cAMP signaling pathway bbis04260   Cardiac muscle contraction bbis04261   Adrenergic signaling in cardiomyocytes bbis04371   Apelin signaling pathway bbis04713   Circadian entrainment bbis04911   Insulin secretion bbis04921   Oxytocin signaling pathway bbis04972   Pancreatic secretion bbis05020   Prion disease bbis05022   Pathways of neurodegeneration - multiple diseases bbis05410   Hypertrophic cardiomyopathy bbis05412   Arrhythmogenic right ventricular cardiomyopathy bbis05414   Dilated cardiomyopathy bbis05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:bbis00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     105003134 (RYR2)    04020 Calcium signaling pathway     105003134 (RYR2)    04024 cAMP signaling pathway     105003134 (RYR2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     105003134 (RYR2)    04921 Oxytocin signaling pathway     105003134 (RYR2)   09153 Circulatory system    04260 Cardiac muscle contraction     105003134 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     105003134 (RYR2)   09154 Digestive system    04972 Pancreatic secretion     105003134 (RYR2)   09159 Environmental adaptation    04713 Circadian entrainment     105003134 (RYR2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     105003134 (RYR2)    05022 Pathways of neurodegeneration - multiple diseases     105003134 (RYR2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     105003134 (RYR2)    05412 Arrhythmogenic right ventricular cardiomyopathy     105003134 (RYR2)    05414 Dilated cardiomyopathy     105003134 (RYR2)    05415 Diabetic cardiomyopathy     105003134 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:bbis04040]     105003134 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:bbis04990]     105003134 (RYR2) Ion channels [BR:bbis04040]  Voltage-gated cation channels   Ryanodine receptor    105003134 (RYR2) Domain-containing proteins not elsewhere classified [BR:bbis04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    105003134 (RYR2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  105003134 NCBI-ProteinID:  XP_010858419 Ensembl:  ENSBBBG00000011403 UniProt:  A0A6P3J166 LinkDB All DBs Position Unknown AA seq 4970 aa AA seqDB search MADGGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTVEKSEGKVDVEKWKFMMKTAQGGGHRTLLYGHAIL LRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWIIHPASKQRSEGEKVRVGDD LILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGH MDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHV TTGKYLSLMEDKSLLLMDKEKADVKSTAFTFRSSKEKLDVGVRKEVDGMGTSEIKYGDSV CYIQHINTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGLNLSRSQHEESRTARVIR STVFLFNRFIRGLDALSKKVKASTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLR ALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAAL IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISL LDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIF LGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGD DLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFE NFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREY KQERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIEL GWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGISDEHAEEK VKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGI QQDVKNRRNPRLVPYALLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARAEVCSG TGERFRIFRAEKTYAVKAGRWYFEFEAVTAGDMRVGWCRPGCQPDQELGSDERAFAFDGF KAQRWHQGNEHYGRSWQAGDVVGCMVDMTEHTMMFTLNGEILLDDSGSELAFKDFDVGDG FIPVCSLGVAQVGRLNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQ VPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSSTDIMFYRLSMPIECAEVFSKTAAG GIPGTGLFGPKNDLEDYDVDSDFEVLMKTAHGHLVPDRGDRDKEATKPEFNNHKDYAQEK PSRLKQRFLLRRTKPDYSTSHSARLTEDVLADERDDYDYLMQTSTYYYSVRIFPGQEPAN VWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESLSPGQGR NNNGLEIGCVVDAASGLLTFTANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRI KNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQ CVEPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHRVAHALCSHV DEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNNEFIVPMTEETKSITLFP DEKKKHGLPGIGLSTSLRPRMQFSSPSFVSINTEGYQYSPEFPLDILKAKTIQMLTEAVK EGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGVFHNEDLKHVLQLIEPSVFKEAASPEEE SEVAEKEPFVEDSKLEGVAEEENKGAKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRH RIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFK DDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDRSLDGNNDLTIRGRLLSLVEKVTYLK KKQAEKPVESDSKKSSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVR ALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPN LMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSY LLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQML VSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGG NGLLAAMEEAIKIAEDPSRDGPSPTTGSSKTPDTEEEEDDTIHMGNAIMTFYSALIDLLG RCAPEMHLIHAAKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGNVVEPDMSAGF CPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYL CTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQL RPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHL SRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGN FNPQPVDTSNITIPEKLEYFINKYAEHAHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPY KLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSVDAAHG YSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKLELEAKGGGNHPLLVPYDTLTAK EKAKDREKAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYI LEFDGGSRSKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKE KEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKSALRAF LDNAAEDLEKTMENLKQGQFTHTRNQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGED LILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLETHLDKHNI YSIYNTKSSRERAALNLPANVEDVCPNIPSLEKLMEEIVDLAESGIRYTQMPHVMEVVLP MLCSYMSRWWEHGPENNPGRAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRLA VFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKSEARGDMSEAELLILDEFT TLARDLYAFYPLLIRFVDYNRAKWLKEPNQEAEDLFRMVAEVFIYWSKSHNFKREEQNFV VQNEINNMSFLIMDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNI CAPGDQELIALAKNRFSLKDTEDEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLPNRTED TSDPEKTVERVLDIANVLFHLEQKSTCMRRRYYNLGSTVEHPQRSKKAVWHKLLSKQRKR AVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGAEPPEEDEG TKRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEEK EMEKQKLLYQQARLHDRGAAEMVLQTISASKGETGPMVAATLKLGIAILNGGNSTVQQKM LDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQDDEFTC DLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDV IDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMK LSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFF DMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENET LDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPFLGRIE IMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTI FEMQLAAQISESDLNERSANKEESEKEKPEEQGPRMGFFSIMTVKSALFALRYNILTLMR MLSLKSLKKQMKKVKKMTVKDMITAFFTSYWSILMSLLHFVASVFRGFSRIIGSLLLGGS LVEGAKKIKVAELLANMPDPTQDEVRGDGEEGERKTLEGGLPSEDLTDLKELSEESDLLS DIFGLDLKREGGQYKLIPHNPNAGLSDLMSNPVPIPEVQEKFQEQKAKEEEKEEKEESKS EPEKAEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQKLLNYFAR NFYNMRMLALFVAFAINFILLFYKVSTSSVVEGKELPTRSSSENARVSSLDSSSPRIIAV HYVLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYI TEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAAL DFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSILGHYNNF FFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSE DGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVI LLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLAN YLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14913 nt NT seq  +upstreamnt  +downstreamnt atggccgatgggggcgagggcgaggatgagatccaattcctgcgaactgatgatgaagtg gtcctgcagtgtaccgcgaccatccacaaagaacaacagaaactatgcttggcggcagaa ggatttggcaacaggctttgcttcttggagtccacttcgaattccaagaatgtccctccc gacctctccatctgcaccttcgtgctggagcagtccttgtctgtccgggccctgcaggag atgctggctaacactgtggaaaagtctgaagggaaggttgatgtggaaaaatggaaattc atgatgaagactgctcaaggtggtggccaccgaacgctcctctacggtcatgcaatactg ctgcggcattcctacagtggcatgtatctgtgctgcctgtccacctctcggtcttcaact gataagctggcttttgatgttggcttgcaagaggatacaacaggtgaagcttgttggtgg atcattcatcctgcctctaagcagcgctcagaaggagaaaaagtgcgggttggagatgac ctcatcttagtgagcgtgtcctctgaaaggtacctgcacttgtcttacggtaacggcagc ttgcacgtggatgctgctttccagcagaccctctggagcgtggcccccatcagctcagga agtgaagcagcccaagggtatctgattggtggtgacgtcctcaggttgcttcatggacac atggatgaatgcctcactgtcccttcaggagaacacggtgaagagcagcggagaactgtt cattacgaaggtggtgctgtatcggttcacgcacgttccctgtggcggctagagacacta agagttgcgtggagtggaagccacataaggtggggacaaccttttcgactacgccatgtc acaacaggaaaatacttgagtctcatggaagacaaaagccttctactcatggacaaagaa aaagctgatgtcaaatcaactgcatttaccttccgatcttccaaggaaaaattggatgta ggagtgagaaaagaagttgatggcatgggaacctctgaaataaaatatggagactcagta tgttatatacagcatatcaatacaggcttatggctgacttaccagtctgtggatgtgaaa tcggtgagaatgggatccatacaacgtaaggctattatgcatcatgaaggacacatggat gatggcctaaatttatccagatctcagcatgaagaatcacggacagcacgtgtcatccgg agcacagtcttcctttttaatagatttattaggggccttgatgctctcagcaaaaaggtg aaagcttccacagtagacttacctatagagtctgtaagtctgagtctgcaggaccttatt ggctacttccacccaccagatgagcatttagagcatgaagataagcagaacagattacga gctctgaagaataggcagaatctcttccaggaagagggaatgatcaaccttgtgctcgag tgtatagacaggctgcatgtgtatagcagtgctgcacacttcgcagatgttgctgggaga gaagcaggggaatcttggaaatcgattctgaattctctgtatgagttgctggcggcatta attagaggaaatcgtaaaaactgtgctcaattttctggctcccttgactggttaatcagc cgactggaaagactggaagcttcttctggtattcttgaagttttacactgtgtgttagta gaaagtccagaagctctaaatattattaaagaaggccatataaaatccattatctcactt ttagacaagcatggaagaaatcacaaggttctggatgtcttatgctctctctgtgtttgc catggagtagcagtccgttctaaccagcatctcatctgtgacaatcttctgccaggaaga gacctgttattgcagacacgccttgtgaaccatgtgagcagcatgagacccaatattttt ctgggtgtcagtgaaggatctgcacagtataagaagtggtattatgagttgatggtggac cacactgagccattcgtgactgctgaagccactcacctgcgagtgggctgggcttccaca gaggggtactcaccctaccctggagggggtgaagagtggggtggaaatggtgtcggagat gacctcttctcctacggatttgatggccttcacctctggtcaggttgtattgcccggacg gtcagctcaccaaaccagcatctcttgagaactgatgatgtcatcagttgctgtctagat ctaagtgccccaagcatctccttccgaattaatggacaacctgttcaaggcatgtttgag aatttcaacattgatggcctcttctttccagttgtcagtttctctgcaggaatcaaagta cgctttctgcttggggggagacatggagaatttaaattccttcctccacctgggtatgct ccttgttatgaagctgtgctgccaaaagagaagttgaaagtggagcacagccgagagtac aagcaagaaaggacttacacgcgggacctcctgggccccacggtttccctgacacaagct gccttcacaccaatcccagtggacaccagccagattgtgttgcctccccacctggagagg atacgagaaaaactggcagagaatatccatgagctctgggtgatgaataaaattgaactt ggctggcagtatggtccggttagagatgacaataagagacagcacccgtgtctggtggag ttctccaagctgcctgaacaggaacgcaattacaatttacagatgtcacttgagaccctg aagacgttgttggctttaggatgtcatgtgggtatatcagatgaacatgctgaagaaaaa gtgaaaaaaatgaagctgccaaagaattaccaactgacaagtggatacaagcctgcccca atggacctgagctttattaaactcaccccatctcaggaggctatggtggacaagctggca gaaaatgctcataacgtgtgggctcgggatcgaattcgacaaggctggacctatgggatc caacaggatgtaaagaacagaagaaaccctcggcttgttccctatgcccttctagatgac cgaaccaagaaatccaataaggatagcctccgtgaggctgtgcgcacactgctgggatat ggctacaacctggaggctcctgatcaagatcatgctgccagagctgaagtgtgcagtggc acgggagagaggttccgcatcttccgtgctgagaaaacatatgctgtgaaggctggaagg tggtattttgaattcgaggcggtcactgctggagacatgcgagttggctggtgcaggcca gggtgtcaacctgatcaggagcttggctcagatgaacgtgcctttgcttttgatggcttc aaggcccagcggtggcaccagggcaatgagcactatgggcgctcttggcaagctggcgac gttgtggggtgtatggttgacatgacagaacacaccatgatgttcacactgaatggcgaa atccttcttgatgattccggttcagagctggctttcaaggactttgatgttggtgatgga ttcatacctgtgtgtagcctgggagtggctcaagtgggcaggctgaactttggaaaggat gtcagcaccttgaaatattttaccatctgtggcttacaagagggctatgaaccatttgcc gttaacacaaatagggatattaccatgtggctgagcaagaggcttcctcaatttctccaa gttccatcaaaccatgaacatattgaggtgaccagaatagatggcaccatagacagttcc ccgtgtttaaaagtcactcagaagtcctttggctctcagaacagcagcacggatatcatg ttttatcgtctgagcatgcccatcgagtgtgcagaggtcttctccaagactgcagctgga gggatccctggcaccgggctctttgggcccaagaatgatctggaggattatgatgtggat tcagactttgaggttctcatgaagacagctcacggccatctggtgccagatcgaggagat agagacaaagaagctacaaaaccagagtttaataaccacaaggattatgctcaggaaaaa ccctctcgtctgaaacagaggtttttgcttcgaagaacaaagccagattatagcaccagc cattctgcacgactcactgaagatgtccttgcagatgagagggatgactatgattacttg atgcaaacgtccacgtactattactcagtgagaatctttcctggacaagaacctgccaat gtctgggtgggctggatcacatccgatttccatcagtatgatacaggctttgacttggac agagttcgtacagtgaccgtgactctgggagatgaaaaaggaaaggtgcacgaaagcatc aaacgcagcaattgctacatggtgtgtgcgggtgagagcctgagcccggggcaaggacgg aacaacaacggcctggagattggctgcgtggtggatgctgctagtgggctgctcaccttc acggccaacggcaaggaactgagcacctattatcaggtggaaccaagcacaaaattattt cctgcagtttttgcacaagctacaagtcctaatgtttttcagtttgagttgggaagaata aagaatgtgatgcctctctcagcgggattattcaagagtgagcacaaaaatcctgtgcca cagtgtcccccacgtctccatgtgcagtttctctcacatgtcctgtggagcagaatgccc aaccagttcttgaaggtagacgtctctcgaataagtgaacgccagggctggctggtgcag tgcgtggagcctctgcagttcatgtcacttcacatcccagaggagaacagatctgtggac atactggaactgacagagcaggaggaactactgaaattccactaccacactctccggctc tactcggccgtctgcgcgctcgggaaccaccgggtggcccacgccttgtgcagccacgtg gacgagccgcagctgctctacgccatcgagaacaagtacatgcccggcttgctgcgcgcc ggctactacgacctgctgattgacatccacctcagctcctacgccaccgccaggctcatg atgaacaacgaattcatcgtccccatgaccgaggagacgaagagcatcaccctcttcccg gatgagaagaaaaagcacgggctcccgggcatcggcctcagcacctccctcaggccgcgg atgcagttttcctccccgagttttgtcagcattaataccgagggttaccagtacagccca gagttcccgctggacatcctgaaggccaagaccatacagatgctcacagaagccgtgaaa gagggcagccttcatgcccgagaccccgttgggggcaccactgagttcctcttcgtccct ctcatcaagctgttctataccctgctcatcatgggtgtcttccacaacgaggacttgaaa cacgtcttgcagttgattgagcctagtgtgttcaaggaagccgccagcccggaggaggag agcgaggtggcggagaaggaaccctttgtggaagactccaagctggaaggagtcgctgag gaagaaaacaaaggggctaagaggcccaaggagggcctgctccaaatgaaactgccagag ccagtaaaattgcagatgtgcctgctacttcagtacctctgtgactgccaggtccggcac cggatagaagccattgtggccttttcagatgactttgtagccaagctccaagacaatcaa cgattccgatataatgaagttatgcaagccttaaacatgtcggctgcactcacagccagg aaaacaaaggaattcagatccccgcctcaagaacagatcaatatgcttctcaattttaag gatgacaaaagtgaatgtccatgtcctgaagaaatccgagaccaactcttggattttcat gaagatttgatgacacattgtggaattgagctggatgaagataggtctctggatggaaac aatgatttaactattagaggacgcctgctgtccttggtagaaaaggtgacatacctgaag aagaagcaagcggaaaagccagttgagagtgactccaagaagtcatccactcttcagcag ttgatttctgagaccatggtccgatgggctcaagagtctgttattgaagaccctgaattg gtgagggccatgtttgtattgctccatcgacagtatgatggcattgggggtctggtacgg gctctgccaaagacctacactataaatggtgtttctgtggaggataccatcaatctgctg gcatctcttggtcagattcgttctctgctaagtgtgagaatgggcaaagaggaagagaaa cttatgattcgtggattaggggatatcatgaacaataaagtgttttaccagcatcctaat ctcatgagggcccttgggatgcatgagacagtgatggaggtcatggtgaatgtccttgga ggtggagagtccaaggaaatcacttttccgaagatggtggccaactgttgccgttttctc tgttacttctgtcgtataagcaggcagaatcagaaagctatgtttgatcatctgagttat ttactggaaaacagcagtgttggtcttgcctcaccagctatgagaggttcaacaccactg gatgtggcagcagcctcggtgatggataataatgaactagctttagctttgcgggagcca gatctggaaaaggtggttcggtatttggctggttgtggactgcagagttgccagatgcta gtgtcaaagggttatccagacattgggtggaatccagttgaaggagagagatatcttgac tttctcagatttgctgtcttctgtaatggggaaagcgtggaggagaatgcaaatgtagtg gtgagattgctcatccggaggcctgagtgtttcggtcccgccttgaggggggaaggtggg aatggcctgcttgcagccatggaagaagccataaaaatagccgaggatccctctagagat ggtccctcaccaactaccggatccagcaaaacccctgatacagaagaggaagaggatgat accatccacatgggaaatgccatcatgacgttttattcagctttaattgacctgttagga cgatgtgctcctgaaatgcatttgattcatgctgccaaaggagaagccatcagaatcagg tctattttgagatctctgattccattgggagatttggtgggagtgatcagcatcgctttt cagatgcccacaatagccaaagatgggaatgtggtggagcctgacatgtctgcagggttt tgtccagatcacaaggcagccatggttttgttccttgacagggtctatggaattgaggtt caagatttcctcctccatcttctcgaggttggctttctgccagatctccgggctgctgct tctttagacacggctgctttgagtgctacagacatggccctggcgctcaatcggtacctg tgcacagccgtgttacccttgttaacaaggtgtgctcctctttttgctggcaccgagcac catgcttctctcattgactcattacttcacactgtgtacaggctttctaagggctgctca cttaccaaagctcaacgggattccatagaagtgtgtttactctctatttgtggccaattg agaccttctatgatgcaacacttactcagaagattagtatttgatgtcccattattaaat gaacatgcaaagatgcctcttaagctgctgacaaatcattatgaaagatgctggaaatat tactgcctgcctggagggtggggcaactttggagctgcctcagaagaagaacttcatttg tcaagaaagctgttctggggcatctttgatgccctgtctcaaaagaaatatgaacaagaa cttttcaaactggcactgccttgcctgagtgcagttgcgggagctttgcctccagactac atggagtcaaattatgtcagtatgatggaaaaacagtcatcaatggattctgaagggaac tttaatccacaacctgttgatacctcaaacattacaattcctgagaagttggaatacttc attaacaaatatgcagaacatgcccatgacaagtggtcaatggataagttggcaaatgga tggatttatggagaaatatattcagactcatctaaagttcaaccattaatgaagccatat aaactattatctgaaaaggaaaaagaaatttatcgctggccaatcaaagaatctttaaaa actatgctggcttggggatggagaattgaaaggacccgagagggagacagcatggccctt tataaccgtactcgtcgtatttctcagacaagtcaggtttctgtagatgccgcccatggg tacagcccacgagccattgacatgagcaatgttacactatccagagatctgcacgctatg gcagaaatgatggctgaaaactaccataatatatgggcaaagaaaaagaaactggaactg gaggccaaaggaggtggaaaccatcccctactggtaccttatgatacactgacagccaaa gagaaagccaaggatagggaaaaagcacaggacatcctcaagttcctgcagatcaatggc tacgctgtatccagagggttcaaagacctggaactggacacaccttctattgagaaacgg tttgcctatagtttccttcagcaactcattcgctatgtagacgaggcccatcagtatatc ctggagtttgatggtggcagcagaagcaaaggagaacatttcccttatgaacaagaaatc aagttctttgctaaagtcgttcttcctttaattgatcagtatttcaaaaaccaccgttta tacttcttatctgcagcaagcagacctctctgttctggaggacatgcatcaaacaaagag aaagaaatggtgactagcctattctgcaaacttggagttcttgtcaggcataggatttca ctatttgggaacgatgcaacatcaattgtcaactgtcttcatattttgggtcagactttg gatgcaaggactgtgatgaagactggcctggagagtgttaaaagtgcactcagagccttc ctggacaatgccgcagaggatctggagaagacgatggagaatcttaagcagggccagttc acccacacccgaaaccaacccaaaggtgttactcagattatcaattataccacggtggca ctgttaccaatgctgtcatcattatttgagcatattggccagcatcagttcggagaagat ctcatattggaagatgtacaggtgtcatgttatagaattctgactagcttgtatgctttg ggaaccagcaagagtatttatgtggaaaggcaacgttctgcattgggagaatgtctggct gcttttgctggtgcctttcctgtagcatttttggaaactcacctggacaagcacaatatt tactccatctacaatacaaagtcttcgagagagagagcagctcttaatttgcctgctaac gtggaagatgtttgtccaaatataccgtctttggagaagctcatggaagaaattgtggac ttggctgagtccgggattcgctacacacagatgccacacgtgatggaagttgtcctgccc atgctttgtagttacatgtctcgttggtgggagcatgggcctgagaataatccgggaagg gctgagatgtgctgtacagctctgaactcagaacacatgaacacgctgctgggcaatatc ctgaaaatcatatataataacttgggtattgatgagggagcctggatgaagaggttagca gtgttttcccagcctattataaataaagtgaaacctcagctcttgaaaactcatttcttg ccattaatggagaagctcaagaaaaaggcagcaatggtggtatcagaagaggaccatctg aaatctgaggccaggggagatatgtctgaagccgaacttctcatcctagatgagttcacc acactggccagagatctctatgccttctatccgctcctgattagatttgtggactataac agggcaaaatggctgaaagagcctaaccaagaagcagaagatcttttccgcatggttgct gaggtgtttatctactggtcaaaatcccataatttcaaaagggaggagcagaactttgtg gtgcagaatgaaatcaacaatatgtctttccttattatggacaccaagtcaaagatgtcc aaggcagctgtttctgatcaggaaaggaagaaaatgaagcgcaaaggggaccgatattcc atgcagacatctcttattgtggccgctctgaagcggttgctgcccattgggttgaacatc tgtgcccctggggaccaggagctcattgcactggccaaaaatcgctttagtctgaaagac actgaggatgaagttcgagatataatccgcagtaatattcacttacaaggcaagttggag gatcccgctattagatggcaaatggctctttacaaagacttacccaataggacagaagac acttcagatcccgagaagacagtggaaagggtcttggatatagcaaatgtactttttcat cttgaacagaaatctacatgtatgcgccggagatattacaatctgggaagtacagttgag catcctcagagatcaaaaaaggccgtgtggcacaaactgctctctaagcagaggaaacga gccgtggttgcttgcttccggatggctcctttatataatctgccgaggcatcgggctgtc aatctctttcttcagggatatgaaaagtcttggattgagacagaagaacattactttgaa gataaattgatagaagacttagcgaaacctggagcagaacctccagaagaagatgaagga actaagagggttgatcctcttcatcagctgatccttctgtttagtcgaacagctttaacg gagaaatgcaaactggaggaagattttttatatatggcttatgcagatattatggcaaag agttgtcatgatgaggaagatgatgatggggaagaggaagtgaagagttttgaagaaaaa gaaatggaaaagcaaaagcttctataccaacaagccaggctccatgaccgcggtgctgct gagatggtgctgcagaccatcagtgccagcaaaggtgaaactggacccatggtggctgct actttgaaacttggaattgctatcttaaatggagggaactctacagtacagcagaaaatg cttgactacctcaaggagaaaaaggacgtgggcttctttcagagcctggctggcctgatg cagtcatgcagtgtcctcgacctaaatgcatttgagcgacaaaacaaagctgaaggactt gggatggtgactgaggaaggatcaggagaaaaggttctgcaggatgacgaattcacctgt gacctcttccgcttcttgcaactgctttgtgagggacacaactcagattttcaaaattat ctgagaactcagactggcaataatacaactgtcaacataatcatctctactgtagactac cttctgagagttcaggaatcaattagtgatttctattggtattactctggaaaagatgtc attgatgaacaaggacaaaggaatttctccaaagctattcaagtggcaaaacaagtcttt aacactcttacagagtatattcagggtccttgcactggcaaccagcagagtttggctcac agcaggctctgggatgctgtggtgggttttcttcatgtatttgcccacatgcagatgaag ctgtctcaggactccagtcaaattgagctactgaaagaattgatggatcttcagaaggac atggtggtcatgttgctgtccatgttggaaggcaatgttgttaatggcaccattggcaaa cagatggttgatatgctcgtggaatcttccaacaacgtggagatgattctcaagtttttt gacatgttcttaaagctcaaggacttgacatcttctgatactttcaaagagtatgacccc gatggtaagggagttatttccaagagggactttcacaaagccatggagagccataaacac tacacccagtccgagactgagtttcttctgtcctgtgcagagacagatgaaaatgaaacc ctggactatgaagaatttgtcaaacggttccacgagcctgccaaggacattggcttcaat gtggcagtgcttctgacaaacctctccgaacacatgcccaatgacacccggctgcagact tttctggaattggccgagagcgtgctcaattacttccagcccttcctgggccgcatcgag atcatgggcagtgccaagcgcatcgagagggtgtattttgaaatcagtgagtccagccga acccagtgggaaaagccccaggtcaaggaatccaaaaggcaatttatatttgacgtggtc aatgaaggaggggagaaagagaagatggagctcttcgtgaacttctgcgaggataccatc tttgagatgcaactggcggctcagatttcagagtcagatctgaatgagaggtcagcgaat aaagaggagagtgagaaggagaagccggaggagcagggtccaaggatgggtttcttttcc atcatgacggtcaagtccgccctgtttgccctcaggtacaatatcttgacccttatgcgg atgctcagcctgaaaagcttgaagaagcagatgaagaaggtgaagaagatgacagtgaag gacatgatcacagccttctttacatcctactggagtattttgatgagcctcctgcacttt gtagccagcgttttcagaggcttctctcgcatcatcggcagcctcctgctgggaggaagc ctggtcgaaggtgcgaagaagatcaaagtggcggagctcttggccaacatgccagacccc acacaagatgaggttcgaggagacggggaggagggggagaggaaaaccctggaagggggc ctgccctctgaagacctgacggacttgaaggaactgtcagaggagagtgacctgctttcc gatatctttggcttggacctgaagcgagaaggagggcagtacaaactgattcctcacaat cccaatgctggcctgagtgacctcatgagcaaccccgtccccatcccagaggtgcaagaa aagttccaggagcagaaggcaaaagaagaagaaaaggaagaaaaagaagaaagcaaatcc gaacccgagaaagctgaaggagaagacggagaaaaagaagaaaaagccaaagaagacaag ggtaaacaaaaactgaggcagctccacacacacagatatggagagccagaagttcctgag tcagcattctggaagaaaatcatagcctatcaacagaaacttctaaactattttgctcgc aacttctacaacatgagaatgttagccttatttgtcgcatttgcgatcaatttcatcttg ctcttttataaggtctccacttcttctgtggttgaaggaaaggaactacccactcgcagt tcaagtgaaaatgccagagttagcagcttggacagcagctcgcctagaatcatcgcagtg cactatgtgctggaggagagcagtggctacatggagcccacactgcggatattagccatt ctgcacacggtcatctctttcttctgtatcattggatactactgcttgaaagtcccactg gttatttttaagcgagagaaggaagtagctcgaaaattggaatttgatgggctttatatt acagaacagccttcagaagatgatattaaaggccagtgggatagactcgtaatcaacaca cagtcatttcccaacaactactgggacaaatttgttaaaagaaaggttatggataaatat ggagagttctatggccgagacagaatcagcgagttactcggcatggacaaagctgccttg gacttcagtgatgcccgggagaagaagaagccaaagaaagacagctccctgtcagctgta ctgaactctattgatgtgaagtatcagatgtggaaactaggagtcgttttcactgacaac tccttcctctaccttgcctggtatatgaccatgtccattcttggacactacaacaacttt ttttttgctgctcatcttctggacattgctatgggattcaagacgttaagaaccatcttg tcatcagtaactcacaatggcaaacagcttgtattaactgttggcttattggctgttgtt gtgtacctatatactgtcgtggcattcaattttttccgaaaattctacaataaaagtgaa gatggcgatacaccagacatgaagtgtgatgacatgctaacgtgctatatgttccacatg tatgttggagtacgtgctggagggggtattggtgatgaaatcgaagatccagctggtgat gaatatgagatatatcgaatcatctttgacatcaccttcttcttttttgtaattgtcatt ctcttggccataatacaaggtttaatcatcgatgcttttggggaactaagagaccaacag gaacaggtcaaagaagacatggagaccaagtgcttcatctgtgggataggcaatgattac tttgacaccgtgccacatggctttgaaacccacactttacaggaacacaacttggccaat tatctgttttttctgatgtatctcataaacaaagatgaaacggagcacacaggacaggaa tcttatgtttggaagatgtatcaagaaaggtgctgggaatttttcccagccggagactgt ttccggaaacagtatgaagaccagctaaattaa

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