Bison bison bison (American bison): 105003978 Help Entry 105003978         CDS       T08726                                  Symbol NF1 Name (RefSeq) neurofibromin isoform X1   KO K08052   neurofibromin 1 Organism bbis  Bison bison bison (American bison) Pathway bbis01521   EGFR tyrosine kinase inhibitor resistance bbis04010   MAPK signaling pathway bbis04014   Ras signaling pathway Brite KEGG Orthology (KO) [BR:bbis00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     105003978 (NF1)    04014 Ras signaling pathway     105003978 (NF1)  09160 Human Diseases   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     105003978 (NF1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PH_NF1 RasGAP CRAL_TRIO_2 CRAL_TRIO MIF4G_like_2 Motif Other DBs NCBI-GeneID:  105003978 NCBI-ProteinID:  XP_010859754 Ensembl:  ENSBBBG00000007088 UniProt:  A0A6P3J5B6 LinkDB All DBs Position Unknown AA seq 2865 aa AA seqDB search MCATKNLTNMKLFPHLEFHRTKINPYLRLPQMIQNVLFSGIQDKLPIKTGQQNTHTKVST EHNKECLINISKYKFSLVISGLTTILKNVNNMRIFGETAEKNLYLSQLIILDTLEKCLAG QPKDTMRLDETMLVKQLLPEICHFLHTCREGNQHAAELRNSASGVLFSLSCNNFNAVFSR ISTRLQELTVCSEDNVDVHDIELLQYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSL EKAFWNWVENYPDEFTKLYQIPQTDMAECAEKLFDLVDGFAESTKRKAAVWPLQIILLIL CPEIIQDISKDVVDENNMNKKLFLDSLRKALAGHGGSRQLTESAAIACVKLCKASTYINW EDNSVIFLLVQSMVVDLKNLLFNPSKPFSRGSQPADVDLMIDCLVSCFRISPHNNQHFKI CLAQNSPSTFHYVLVNSLHRIITNSALDWWPKIDAVYCHSVELRNMFGETLHKAVQGCGA HPAIRMAPSLTFKEKVTSLKFKEKPTDLETRSYKYLLLSMVKLIHADPKLLLCNPRKQGP ETQGSTAELITGLVQLVPQSHMPEIAQEAMEALLVLHQLDSIDLWNPDAPVETFWEISSQ MLFYICKKLTSHQMLSSTEILKWLREILICRNKFLLKNKQADRSSCHFLFLYGVGCDVPS SGNTSQMSMDHDELLRTCAPGTSLRKGKGNSSMDSAAGCSGTPPICRQAQTKLEVALYMF LWSPDTEAVLVAMSCFRHLCEEADIRCGVDEVSVHNFLPNYNTFMEFASVSNMMSTGRAA LQKRVMALLRRIEHPTAGNTEAWEDTHAKWEQATKLILNYPKAKMEDGQAAESLHKTIVK RRMSHVSGGGSIDLSDTDSLQEWINMTGFLCALGGVCLQQRSNSGLATYSPPMGPVSERK GSMISVMSSEGNADTPVSKFMDRLLSLMVCNHEKVGLQIRTNVKDLVGLELSPALYPMLF NKLKNTISKFFDSQGQVLLTDTNTQFVEQTIAIMKNLLDNHTEGSSEHLGQASIETMMLN LVRYVRVLGNMVHAIQIKTKLCQLVEVMMARRDDLSFCQEMKFRNKMVEYLTDWVMGTSN QAADDDVKCLTRDLDQASMEAVVSLLAGLPLQPEEGDGVELMEAKSQLFLKYFTLFMNLL NDCSEVEDENAQTGGRKRGMSRRLASLRHCTVLAMSNLLNANVDSGLMHSIGLGYHKDLQ TRATFMEVLTKILQQGTEFDTLAETVLADRFERLVELVTMMGDQGELPIAMALANVVPCS QWDELARVLVTLFDSRHLLYQLLWNMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGA TYLQKLLDPLLRVVITSSDWQHVSFEVDPTRLEQSESLEENQRNLLQMTEKFFHAIISSS SEFPPQLRSVCHCLYQATCHSLLNKATVKEKKENKKSVVSQRFPQNSIGAVGSAMFLRFI NPAIVSPYEAGILDKKPPPRIERGLKLMSKILQSIANHVLFTKEEHMRPFNDFVKSNFDA ARRFFLDIASDCPTSDAVNHSLSFISDGNVLALHRLLWNNQEKIGQYLSSNRDHKAVGRR PFDKMATLLAYLGPPEHKPVADTHWSSLNLTSSKFEEFMTRHQVHEKEEFKALKTLSIFY QAGTSKAGNPIFYYVARRFKTGQINGDLLIYHVLLTLKPYYAKPYEIVVDLTHTGPSNRF KTDFLSKWFVVFPGFAYDNVSAVYIYNCNSWVREYTKYHERLLTGLKGSKRLIFIDCPGK LAEHIEHEQQKLPAATLALEEDLKVFHNALKLAHKDTKVSIKVGSTAVQVTSAERTKVLG QSVFLNDIYYASEIEEICLVDENQFTLTIANQGTPLTFMHQECDAIVQSIIHIRTRWELS QPDSIPQHTKIRPKDVPGTLLNIALLNLGSSDPSLRSAAYNLLCALTCTFNLKIEGQLLE TSGLCIPANNTLFIVSISKTLAANEPHLTLEFLEECISGFSKSSIELKHLCLEYMTPWLS NLVRFCKHNDDAKRQRVTAILDKLITMTINEKQMYPSIQAKIWGSLGQITDLLDVVLDSF IKTSATGGLGSIKAEVMADTAVALASGNVKLVSSKVIGRMCKIIDKTCLSPTPTLEQHLM WDDIAILARYMLMLSFNNSLDVAAHLPYLFHVVTFLVATGPLSLRASTHGLVINIIHSLC TCSQLHFSEETKQVLRLSLTEFSLPKFYLLFGISKVKSAAVIAFRSSYRDRSFSPGSYER ETFALTSLETVTEALLEIMEACMRDIPTCKWLDQWTELAQRFAFQYNPSLQPRALVVFGC ISKRVSHGQIKQIIRILSKALESCLKGPDTYNSQVLIEATVIALTKLQPLLNKDSPLHKA LFWVAVAVLQLDEVNLYSAGTALLEQNLHTLDSLRIFNDKSPEEVFMAIRNPLEWHCKQM DHFVGLNFNSNFNFALVGHLLKGYRHPSPAIVARTVRILHTLLALVNKHRNCDKFEVNTQ SVAYLAALLTVSEEVRSRCSLKHRKSLLLTDISMENVPMDTYPIHHGDPSYRTLKEHQPW SSPKASEGYLAASYPPAGQTSPRARKSMSLDMGQPSQANTKKLLGTRKSFDHLISDTKAP KRQEMESGITTPPKMRRVAETDYEMETQRISSSQQHPHLRKVSVSESNVLLDEEVLTDPK IQALLLTVLATLVKYTTDEFDQRILYEYLAEASVVFPKVFPVVHNLLDSKINTLLSLCQD PNLLNPIHGIVQSVVYHEESPPQYQTSYLQSFGFNGLWRFAGPFSKQTQIPDYAELIVKF LDALIDTYLPGIDEETSEESLLTPTSPYPPAVQSQLSITANLNLSNSMTSLATSQHSPGI DKENVELSPTTGHCNSGRTRHGSASQVQKQRSAGSFKRNSIKKIV NT seq 8598 nt NT seq  +upstreamnt  +downstreamnt atgtgtgcaaccaagaacctgaccaatatgaaattattcccacatttggaattccataga acgaagataaacccttatcttagacttccacagatgatacagaatgtactcttttctggg atccaagacaagcttccaataaaaacaggacagcagaacacacataccaaagtcagcact gagcacaacaaggaatgtcttatcaatatttccaaatacaagttttctttggttataagt ggcctcaccactatcttaaagaatgttaacaatatgagaatatttggagaaactgctgaa aaaaatttgtatctctctcagttgattatattggatacactggaaaaatgtcttgctggg caaccaaaggacacaatgagattagatgaaacgatgctggtcaaacagttgctgccagaa atctgccattttcttcatacttgtcgtgaaggaaaccaacatgcagctgaacttcggaat tctgcctctggggtgttattttctcttagctgcaacaacttcaatgcagtctttagtcga atttctaccaggttacaggaattgactgtttgttcagaagacaatgtggatgttcatgat atagaactgttacagtatattaatgtggattgtgcaaaattaaaacgactcctgaaggaa acagcatttaaatttaaagccctaaagaaagttgcacagttagcagttataaatagcctg gaaaaagcattttggaactgggtagaaaattatccagatgaatttacaaagctgtaccag attccacagactgatatggctgagtgtgccgaaaaactgtttgacttagtggatggtttt gctgaaagcaccaaacgtaaagcagcagtttggccactacaaatcattctgcttatcttg tgtccagaaataatccaggatatatccaaggatgtggttgatgaaaacaacatgaataag aagttgtttctggacagtctgcgaaaagcacttgccggccatggaggaagcaggcagctc actgaaagtgctgcaatcgcctgtgtcaaactgtgtaaagcaagtacttacatcaattgg gaagataactctgtcatctttctgctggttcagtccatggtggttgatcttaagaacctg ctgtttaatccgagtaagccattctcgaggggcagtcagccggcagatgtggacctaatg atcgactgccttgtctcttgcttccggataagccctcacaataaccaacacttcaagatc tgcctggctcagaattccccttctacatttcactatgtgctggtaaattcactccatcga atcatcaccaattctgcattggattggtggcctaagattgatgctgtatattgccactca gttgaacttcgaaatatgtttggtgaaacacttcataaagcagtccagggttgtggagca cacccagcaatacgaatggcaccgagtcttacatttaaagaaaaagtaacaagccttaaa tttaaagaaaaacctacagacctggagacaagaagctacaagtatcttctcttgtccatg gtgaaactaattcatgcagatccgaagctcttgctttgtaatccaagaaaacaggggcct gaaacccaaggcagtactgcagaattaattacagggcttgtccagctggtccctcagtca cacatgccagagattgcccaggaagcgatggaggctctgctggttcttcatcagttagat agcattgatttgtggaatcctgatgctcctgtagaaacattttgggaaattagctcacaa atgcttttttacatttgcaagaaattgactagtcatcaaatgcttagtagcacagaaatt ctcaaatggttgcgggaaattttgatctgcaggaataaatttcttcttaaaaataagcag gcagatagaagttcctgtcactttctcttcctttatggagtaggatgtgatgttccttca agtgggaataccagtcaaatgtccatggatcatgacgaattactacgcacttgtgctcct ggaacctctctcaggaaggggaaaggaaattcatccatggatagtgcagcagggtgcagt ggaaccccaccaatatgccgacaagcccagaccaaactagaagtggccctgtacatgttc ctgtggagccccgacactgaagcagttctggttgccatgtcctgttttcgtcacctctgt gaggaagcagatatccggtgtggggtggatgaagtgtcagtacacaacttcttgcccaac tataacacattcatggaatttgcttctgttagcaatatgatgtcaacaggaagagcagca cttcagaaaagagtgatggcgctactacggcgaattgagcatcccactgcaggaaacact gaggcttgggaagatacgcatgcaaagtgggaacaagctacaaaactaatcctcaactac ccaaaagccaaaatggaagatggccaggctgctgaaagccttcacaagaccattgttaag aggcgaatgtctcatgtgagtggaggaggatccatagatttatctgacacggactcacta caagaatggatcaacatgactggcttcctttgtgcccttgggggagtgtgcctgcagcag agaagcaattctggcttagcaacatatagcccacccatgggccctgtcagtgaacgcaag ggttccatgatttcagtgatgtcttcagagggaaatgcagatacacctgtcagcaaattt atggatcggctgctgtccttaatggtctgtaaccatgagaaagtgggacttcaaatacgg accaatgttaaggatctggtgggtctagaattgagtcctgctctttatccaatgcttttt aacaaactgaagaataccatcagcaagttttttgactcccaaggacaggttttattgact gacaccaatactcagtttgtggagcaaaccatagctataatgaagaacttactagataat cataccgaaggcagttctgaacatctggggcaagccagcattgaaacaatgatgttaaat ctggtcagatatgttcgtgtacttggaaatatggttcatgcaattcaaataaaaacaaaa ctgtgtcagttagtcgaggtaatgatggcaaggagagatgacctctcattttgtcaagag atgaaattcaggaataagatggtagaatacttgacagattgggttatgggaacatcaaac caagcggcagatgacgatgtaaaatgtcttacaagagatttggaccaggcaagcatggaa gcagtagtttcactcctggctggtctgccgctgcagcctgaggaaggagatggtgtggag ttgatggaagccaaatcacagttgtttcttaagtatttcacattgtttatgaaccttttg aacgactgcagtgaagtcgaagatgaaaatgcacaaacaggtggcaggaaacgtggcatg tctcggaggctggcatcactgaggcactgcacagtcctggcaatgtcaaacttactcaat gctaacgtggacagcggcctcatgcactccataggcttaggttatcacaaagatctccag acaagagctacgtttatggaagttctgacaaaaatccttcaacaaggcacagagtttgac acacttgcagaaacagtattggcagatcgttttgagagactggtggagttggtcacgatg atgggtgatcaaggagagctccctatagccatggctctggccaatgtggttccctgttct cagtgggatgaacttgctcgcgttctagtgactctgtttgactctcggcatttgctctac caactgctctggaacatgttttctaaggaagtagaattggcagactctatgcagactctt ttccgaggcaacagcttggccagtaaaataatgaccttctgtttcaaggtatatggtgct acctacctacagaaactcctggatcctttattacgggttgtgatcacctcctctgattgg cagcacgtcagctttgaagtggatcctaccaggttagaacagtcagagagccttgaggaa aaccaacgaaatctccttcaaatgactgaaaagttcttccatgccatcatcagttcgtcc tccgaatttccccctcaactacgaagtgtgtgccactgtttgtaccaggcaacttgccac tccctactgaataaagctacagtaaaagaaaaaaaggaaaacaaaaaatcagtggttagc cagcgtttccctcagaacagcatcggtgcagtaggaagtgccatgtttctcagatttatc aatcctgccattgtctcaccatatgaagcagggattttagataaaaagccaccgcctaga atcgaaaggggcttgaagttaatgtcgaagatacttcagagtattgccaatcatgtcctt ttcacaaaagaagaacatatgcggccttttaatgattttgtgaaaagcaactttgatgca gcacgaaggtttttccttgatatagcatctgattgtcctacaagtgatgctgtaaatcat agtctttccttcatcagcgatggcaatgtgcttgctttacatcgtctactatggaataat caagagaaaattggccagtatctttccagcaacagggatcacaaagctgttggaagacga ccttttgataagatggcaacacttcttgcatacctgggtcctccagagcacaaacctgtg gcagatacacactggtccagccttaaccttaccagttcgaagtttgaggagtttatgact aggcatcaagtacatgaaaaagaagagttcaaggctttgaaaacattaagtattttctac caagctgggacttccaaagctgggaatcctatattttattatgttgcacggaggttcaaa acaggtcaaatcaatggtgatttgctgatataccacgtcttgctgactttaaagccatat tatgcaaagccatatgaaattgtagtggaccttacccatactgggcctagcaatcgcttt aaaacagactttctctccaagtggtttgtggtttttcctggctttgcttatgataatgtc tctgcagtatatatctataactgtaactcctgggtcagggaatataccaagtatcatgag cggctgctgactggcctcaaaggcagcaaaagactcattttcatagactgtcctgggaaa ctggctgagcacattgagcatgaacagcagaaactacctgctgccaccttggctttagaa gaggacctgaaggttttccacaacgctctcaagctagctcacaaagacaccaaggtgtct attaaagttggttctactgctgttcaagtaacctctgcagagcgaacaaaagtcctgggg caatcagtctttctaaatgatatctattatgcctcagaaattgaagagatctgcctggtg gacgagaaccagttcaccttaactattgcaaaccagggcacaccgctcaccttcatgcac caggagtgtgatgccattgttcagtctatcattcacatccggacacgttgggagctgtcg caaccagactccattccccagcacaccaagattcggccaaaagacgtccctgggacacta ctcaatattgcattacttaatttaggcagttcagaccctagtttacggtcagctgcctat aatcttctgtgtgccttaacttgtacctttaatttaaaaattgagggccagttactagag acgtcaggtttatgtatcccagccaacaacaccctctttattgtctctattagtaagacc ctggcagccaatgagccacacctcaccctagaatttttggaagagtgtatttctggattt agcaaatctagtattgaattgaaacacctttgtttggagtacatgactccatggctatca aatctagtacgtttttgtaagcacaacgatgatgccaagcgacagagagttactgcaatt cttgataagctgataacaatgaccataaacgagaaacagatgtatccatctattcaagca aaaatatgggggagccttgggcagattacagacctccttgatgttgtactagacagtttc atcaaaaccagtgcaacgggtggcttaggatcaataaaggctgaggtgatggcagatact gctgtagctttggcttctggaaatgtgaaattggtttcaagcaaggttattggaaggatg tgcaaaataattgacaagacatgcctatctccaactcctactttagagcaacatcttatg tgggatgatattgccattctggctcgctacatgctaatgctgtccttcaacaattccctg gacgtggcagctcatctcccctacctcttccacgttgttactttcttagtagcaacaggg ccactctccttgagagcttccacacatggattggtcattaacatcattcactctctgtgt acttgttcacagcttcattttagtgaagagaccaagcaagttttgagactcagcttgaca gagttctcattaccgaaattttacctgctatttggcattagcaaagtcaagtcagctgct gtcattgccttccgctccagctaccgggacaggtcattctctcctggctcctatgagagg gagacttttgctttgacatccttggagacagtcacagaggctttgttggagatcatggag gcatgtatgagagatattccaacatgcaagtggctggaccaatggacagaactagcacaa agatttgcattccagtataacccgtccctgcaaccgagagctcttgttgtctttggctgt attagcaaacgagtatctcatgggcagataaagcagattatccgtatcctcagcaaggct cttgagagttgcttaaaaggacctgatacttacaacagtcaagttctgatagaagctaca gtaatagcactaaccaaattacaaccacttcttaataaggactcccctctgcacaaagcc ctcttttgggttgctgtagccgtgctacagctcgatgaggtcaacttgtattcagcaggc actgcacttctggaacaaaacctgcacaccttagacagtctcaggatattcaacgacaag agtccagaggaagtgttcatggcaatccggaaccctctggaatggcactgcaaacaaatg gatcattttgttggactcaatttcaactctaactttaacttcgcactggttggacacctc ttaaaaggatacaggcatccttcacctgccattgttgcaagaacagtcagaattttgcat acactactagctctggttaataaacacagaaattgtgacaaatttgaggtgaatacacag agcgtggcttacttggcagctttacttacagtgtctgaggaagttcgaagtcgctgtagc ctaaaacatagaaagtctctgcttcttactgatatttcaatggaaaatgttcctatggat acatatcccattcatcatggtgaccctagctataggacactaaaggagcatcagccgtgg tcatctcccaaagcttctgaagggtaccttgcagccagctatccacctgcgggccagacc agtccccgagccaggaaatctatgagcttggacatggggcagccttctcaggccaacacg aagaaattgcttggaacaaggaaaagttttgatcacttgatatcagacacaaaggctcct aaaaggcaagaaatggaatcagggatcacaacaccccccaaaatgaggagagtagcagaa actgattatgaaatggaaacccaaaggatttcctcatcacagcagcacccacatttacgc aaagtttcagtgtctgaatcaaatgttcttttagatgaagaagtacttactgatccgaag atccaagcacttcttcttactgttctggctacactggtgaaatacaccacagatgagttt gatcaacgaattctttatgaatacttagcagaagccagtgttgttttccccaaagttttt cctgttgtgcacaatttgttggactctaagatcaacaccctgttgtcattgtgccaagat ccaaatttgttaaatccgatccatggaattgtgcaaagtgtggtgtaccatgaagaatcc ccaccacaataccaaacatcttacctgcaaagttttggttttaacggcttatggaggttt gcaggacccttttcaaagcaaacacaaatcccagactatgctgagctaattgttaagttt cttgatgccttgattgacacgtatttgcctggaattgatgaagaaaccagtgaggagtcc ctcctgacacccacatctccttatcctcctgcagtgcagagccagcttagtattactgct aaccttaacctttctaattccatgacctcacttgcaacttcccagcattccccaggaatc gacaaggagaatgttgaactctcccccaccactgggcactgtaacagtggacgaactcgc catggatccgcaagccaggtgcagaagcagagaagtgctggcagtttcaaacgtaatagc attaagaagatcgtgtga

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