Bison bison bison (American bison): 105004616
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Entry
105004616 CDS
T08726
Symbol
GART
Name
(RefSeq) trifunctional purine biosynthetic protein adenosine-3
KO
K11787
phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase [EC:
6.3.4.13
2.1.2.2
6.3.3.1
]
Organism
bbis
Bison bison bison (American bison)
Pathway
bbis00230
Purine metabolism
bbis00670
One carbon pool by folate
bbis01100
Metabolic pathways
bbis01523
Antifolate resistance
Module
bbis_M00048
De novo purine biosynthesis, PRPP + glutamine => IMP
Brite
KEGG Orthology (KO) [BR:
bbis00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
105004616 (GART)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
105004616 (GART)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
105004616 (GART)
Enzymes [BR:
bbis01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.2 Hydroxymethyl-, formyl- and related transferases
2.1.2.2 phosphoribosylglycinamide formyltransferase 1
105004616 (GART)
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.3 Cyclo-ligases
6.3.3.1 phosphoribosylformylglycinamidine cyclo-ligase
105004616 (GART)
6.3.4 Other carbon-nitrogen ligases
6.3.4.13 phosphoribosylamine---glycine ligase
105004616 (GART)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
GARS_A
Formyl_trans_N
AIRS_C
GARS_N
GARS_C
AIRS
ATP-grasp
ATP-grasp_2
ATP-grasp_3
CPSase_L_D2
Dala_Dala_lig_C
ATP-grasp_4
RimK
Motif
Other DBs
NCBI-GeneID:
105004616
NCBI-ProteinID:
XP_010860577
Ensembl:
ENSBBBG00000017806
UniProt:
A0A6P3J9A5
LinkDB
All DBs
Position
Unknown
AA seq
1010 aa
AA seq
DB search
MAARVLVIGNGGREHTLAWKLAQSTHVKQVLVTPGNAGTACSEKISNTDISISDHTALAQ
FCKDEKIEFVVVGPEAPLAAGIVGNLNSVGVRCFGPTAQAAQLESSKRFAKEFMDRHGIS
TARWRAFTKPKEACDFIMSADFPALVVKASGLAAGKGVIVAKSKEEACEAVREIMQGKAF
GEAGETVVIEELLEGEEVSCLCFTDGRTVAPMPPAQDHKRLLEGDEGPNTGGMGAYCPAP
QVSKDLLLKIKNNILQRTVDGMQEEGMPYTGVLYAGIMLTKNGPKVLEFNCRFGDPECQV
ILPLLKSDLYEVIQSILDGLLCTSLPVWLDNCAAVTVVMASKGYPGDYTKGVEITGFPEA
QALGLEVFQAGTALKDGKVVTNGGRVLTVTAIRENLISALEEARKGLAAIKFEGAVYRKD
IGFRAIAFLQQPRGLTYKESGVDIAAGNMLVQKIKPLAKATSRPGCDVDLGGFAGLFDLK
AAGFTDPLLACGTDGVGTKLKIAQQCSKHDTIGQDLVAMCVNDILAQGAEPLFFLDYFSC
GKLDLRTTEAVITGIAKACKKAGCALLGGETAEMPDMYPPGEYDLAGFAVGAMERDQKLP
QLERITEGDAVIGIASSGLHSNGFSLVRKIVAKSSLEYSSPAPGGCGDQTLGDLLLTPTK
IYSRSLLPVLRSGHVKAVAHITGGGLLENIPRVLPQKLGVNLDAQTWRVPRIFSWLQQEG
HLSEEEMARTFNCGIGAALVVSEDLVKQTLQDIEQHQEEACVIGRVVACPEGSPRVKVEH
LIETMQINGSVLENGTLRNHFSVQPKKARVAVLISGTGSNLQALIDSTREPSSLAHIVIV
ISNKAAVAGLDKAEKAGIPTRVINHKLYKNRAAFDTAIDEVLEEFSTDIVCLAGFMRILS
GPFVRKWNGKMLNIHPSLLPSFKGSNAHEQVLDAGVTVTGCTVHFVAEDVDAGQIILQEA
VPVKRGDTVETLSERVKLAEHKIFPSALQLVASGAVRLGENGRICWVTED
NT seq
3033 nt
NT seq
+upstream
nt +downstream
nt
atggcagcccgagtacttgtcattggcaatggaggacgagaacacacgctggcctggaaa
cttgcacagtctactcatgttaaacaagtgttggttaccccaggaaatgcaggcactgcc
tgctctgagaagatttcaaatactgacatctcaatcagtgatcatactgcccttgcgcag
ttctgcaaagatgagaaaattgaattcgtagttgttggaccagaggcacctctagctgct
ggaattgttgggaacctgaactctgtgggagttcggtgctttggccccacagcacaagca
gctcagttagagtccagcaagagatttgccaaagagtttatggaccgacatggaatctca
actgcaagatggagagctttcactaaacctaaagaagcctgtgacttcattatgagtgca
gacttccctgctttggttgtgaaggccagtggtcttgcagctgggaaaggggtaattgtt
gccaagagcaaagaggaggcctgtgaagctgtcagagagattatgcagggtaaagctttc
ggagaagcaggagaaacagttgtcattgaagaacttcttgaaggagaagaggtgtcttgt
ctgtgcttcactgatggacggactgtggcccccatgcccccagcacaggaccataagcga
ttgctggagggcgatgagggccccaacacgggaggaatgggagcctattgtccagcccct
caggtttctaaggatttgttgctaaaaattaaaaataatattcttcagaggacagtggat
ggcatgcaggaggagggtatgccatacacaggtgtcctctatgctggtataatgctgacc
aagaacggccccaaagttctggaatttaattgccgtttcggtgatccagagtgccaagtg
atcctcccacttcttaaaagtgatctttatgaagtgattcagtctatcttagatggcttg
ctctgcacttctctgcctgtttggctggacaactgtgctgccgtaactgtggtcatggca
agtaaaggttatccaggagactacaccaagggtgtagagataacagggtttcctgaggct
caggctttaggactggaggtgttccaagcaggcactgccctaaaagatggcaaggtggtg
actaacgggggtagggtccttactgtcacggccatcagggaaaatctcatctcagctctt
gaagaagccaggaaaggacttgccgccataaagtttgagggagctgtttataggaaagac
atcggctttcgagccatagctttcctccagcagcccaggggcctgacttacaaggaatct
ggggtagacattgcagctggtaatatgctggtccagaaaattaaacctttagcaaaggcc
acctccagaccaggctgtgatgttgatcttggaggttttgctggtctttttgatttgaaa
gcagctggtttcactgatcctcttctggcttgtggaacagatggcgttgggacgaaactg
aagattgcccagcagtgcagtaaacatgacaccattggtcaggatttggttgcgatgtgt
gtaaatgacattctggcacaaggagcagagcccctctttttcctcgattacttttcctgt
ggaaaacttgacctccgtactactgaagctgttatcactgggatcgccaaagcttgtaaa
aaggctggatgtgctctcctcggaggtgaaacggcagagatgcctgacatgtaccctcct
ggagagtatgatctagctggttttgctgttggcgccatggagcgggatcagaaacttcct
caactggaaagaatcacggaaggagacgctgttattggaatcgcttcatctggtcttcac
agcaacggattcagccttgtgaggaaaattgtagcaaaatcttctctcgagtactcttct
ccagcacctggtggctgtggtgaccagaccttaggtgacttacttctaaccccaaccaaa
atctacagccgctcactgttacctgtcctgcgttcaggacatgttaaggccgttgcacat
attactggtggaggattactggaaaacatccccagagtcctccctcagaaattgggggtg
aatttagatgcccagacctggagggtccccaggatcttctcatggttacagcaggaaggc
cacctctctgaagaggagatggccagaacatttaactgtgggattggggctgccctcgtg
gtatcagaggacctggtgaagcagactctgcaggatattgagcagcaccaggaagaagcc
tgcgtgatcggcagagtggttgcatgtcccgagggttctcctcgtgtgaaagtcgagcat
ctgattgaaaccatgcaaataaatggatcagtattggagaatggaaccctgagaaatcat
ttctctgttcaaccaaaaaaggcaagagttgctgtcttaatttctgggacaggatcgaac
ctccaagctctcatagacagcactagggagccaagtagcttggcacacattgtcattgtg
atctccaacaaagctgcagtggctggcttagataaagcagaaaaagccgggattcccacg
agagtaattaatcataaattatataaaaatcgtgcagcatttgacactgcaattgacgaa
gtccttgaagagttctccacagacatagtctgtcttgcaggattcatgagaattttgtct
ggccccttcgtcagaaaatggaatgggaaaatgctcaatatccacccatccttgctccct
tcgtttaagggttcaaatgcccatgaacaagtcctggacgctggggtcacagtcaccggg
tgcaccgtgcactttgtagctgaagatgtagatgccggtcaaattatcttacaggaagcc
gttccagtgaagaggggtgacactgttgaaactctatctgagagagtaaaattagcagaa
cataaaatatttccctcagccctccagctggtggccagtggagctgtacggcttggagaa
aatggcagaatctgttgggtcacagaggactga
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