KEGG   Bison bison bison (American bison): 105004742
Entry
105004742         CDS       T08726                                 
Symbol
RAF1
Name
(RefSeq) RAF proto-oncogene serine/threonine-protein kinase
  KO
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
bbis  Bison bison bison (American bison)
Pathway
bbis01521  EGFR tyrosine kinase inhibitor resistance
bbis01522  Endocrine resistance
bbis04010  MAPK signaling pathway
bbis04012  ErbB signaling pathway
bbis04014  Ras signaling pathway
bbis04015  Rap1 signaling pathway
bbis04022  cGMP-PKG signaling pathway
bbis04024  cAMP signaling pathway
bbis04062  Chemokine signaling pathway
bbis04068  FoxO signaling pathway
bbis04071  Sphingolipid signaling pathway
bbis04072  Phospholipase D signaling pathway
bbis04140  Autophagy - animal
bbis04150  mTOR signaling pathway
bbis04151  PI3K-Akt signaling pathway
bbis04210  Apoptosis
bbis04218  Cellular senescence
bbis04270  Vascular smooth muscle contraction
bbis04360  Axon guidance
bbis04370  VEGF signaling pathway
bbis04371  Apelin signaling pathway
bbis04510  Focal adhesion
bbis04540  Gap junction
bbis04550  Signaling pathways regulating pluripotency of stem cells
bbis04613  Neutrophil extracellular trap formation
bbis04625  C-type lectin receptor signaling pathway
bbis04630  JAK-STAT signaling pathway
bbis04650  Natural killer cell mediated cytotoxicity
bbis04660  T cell receptor signaling pathway
bbis04662  B cell receptor signaling pathway
bbis04664  Fc epsilon RI signaling pathway
bbis04666  Fc gamma R-mediated phagocytosis
bbis04720  Long-term potentiation
bbis04722  Neurotrophin signaling pathway
bbis04726  Serotonergic synapse
bbis04730  Long-term depression
bbis04810  Regulation of actin cytoskeleton
bbis04910  Insulin signaling pathway
bbis04912  GnRH signaling pathway
bbis04914  Progesterone-mediated oocyte maturation
bbis04915  Estrogen signaling pathway
bbis04916  Melanogenesis
bbis04917  Prolactin signaling pathway
bbis04919  Thyroid hormone signaling pathway
bbis04921  Oxytocin signaling pathway
bbis04926  Relaxin signaling pathway
bbis04928  Parathyroid hormone synthesis, secretion and action
bbis04929  GnRH secretion
bbis04935  Growth hormone synthesis, secretion and action
bbis05010  Alzheimer disease
bbis05022  Pathways of neurodegeneration - multiple diseases
bbis05034  Alcoholism
bbis05132  Salmonella infection
bbis05152  Tuberculosis
bbis05160  Hepatitis C
bbis05161  Hepatitis B
bbis05163  Human cytomegalovirus infection
bbis05164  Influenza A
bbis05165  Human papillomavirus infection
bbis05167  Kaposi sarcoma-associated herpesvirus infection
bbis05170  Human immunodeficiency virus 1 infection
bbis05200  Pathways in cancer
bbis05205  Proteoglycans in cancer
bbis05206  MicroRNAs in cancer
bbis05207  Chemical carcinogenesis - receptor activation
bbis05208  Chemical carcinogenesis - reactive oxygen species
bbis05210  Colorectal cancer
bbis05211  Renal cell carcinoma
bbis05212  Pancreatic cancer
bbis05213  Endometrial cancer
bbis05214  Glioma
bbis05215  Prostate cancer
bbis05218  Melanoma
bbis05219  Bladder cancer
bbis05220  Chronic myeloid leukemia
bbis05221  Acute myeloid leukemia
bbis05223  Non-small cell lung cancer
bbis05224  Breast cancer
bbis05225  Hepatocellular carcinoma
bbis05226  Gastric cancer
bbis05230  Central carbon metabolism in cancer
bbis05231  Choline metabolism in cancer
bbis05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:bbis00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    105004742 (RAF1)
   04012 ErbB signaling pathway
    105004742 (RAF1)
   04014 Ras signaling pathway
    105004742 (RAF1)
   04015 Rap1 signaling pathway
    105004742 (RAF1)
   04370 VEGF signaling pathway
    105004742 (RAF1)
   04371 Apelin signaling pathway
    105004742 (RAF1)
   04630 JAK-STAT signaling pathway
    105004742 (RAF1)
   04068 FoxO signaling pathway
    105004742 (RAF1)
   04072 Phospholipase D signaling pathway
    105004742 (RAF1)
   04071 Sphingolipid signaling pathway
    105004742 (RAF1)
   04024 cAMP signaling pathway
    105004742 (RAF1)
   04022 cGMP-PKG signaling pathway
    105004742 (RAF1)
   04151 PI3K-Akt signaling pathway
    105004742 (RAF1)
   04150 mTOR signaling pathway
    105004742 (RAF1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    105004742 (RAF1)
  09143 Cell growth and death
   04210 Apoptosis
    105004742 (RAF1)
   04218 Cellular senescence
    105004742 (RAF1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    105004742 (RAF1)
   04540 Gap junction
    105004742 (RAF1)
   04550 Signaling pathways regulating pluripotency of stem cells
    105004742 (RAF1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    105004742 (RAF1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    105004742 (RAF1)
   04625 C-type lectin receptor signaling pathway
    105004742 (RAF1)
   04650 Natural killer cell mediated cytotoxicity
    105004742 (RAF1)
   04660 T cell receptor signaling pathway
    105004742 (RAF1)
   04662 B cell receptor signaling pathway
    105004742 (RAF1)
   04664 Fc epsilon RI signaling pathway
    105004742 (RAF1)
   04666 Fc gamma R-mediated phagocytosis
    105004742 (RAF1)
   04062 Chemokine signaling pathway
    105004742 (RAF1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    105004742 (RAF1)
   04929 GnRH secretion
    105004742 (RAF1)
   04912 GnRH signaling pathway
    105004742 (RAF1)
   04915 Estrogen signaling pathway
    105004742 (RAF1)
   04914 Progesterone-mediated oocyte maturation
    105004742 (RAF1)
   04917 Prolactin signaling pathway
    105004742 (RAF1)
   04921 Oxytocin signaling pathway
    105004742 (RAF1)
   04926 Relaxin signaling pathway
    105004742 (RAF1)
   04935 Growth hormone synthesis, secretion and action
    105004742 (RAF1)
   04919 Thyroid hormone signaling pathway
    105004742 (RAF1)
   04928 Parathyroid hormone synthesis, secretion and action
    105004742 (RAF1)
   04916 Melanogenesis
    105004742 (RAF1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    105004742 (RAF1)
  09156 Nervous system
   04726 Serotonergic synapse
    105004742 (RAF1)
   04720 Long-term potentiation
    105004742 (RAF1)
   04730 Long-term depression
    105004742 (RAF1)
   04722 Neurotrophin signaling pathway
    105004742 (RAF1)
  09158 Development and regeneration
   04360 Axon guidance
    105004742 (RAF1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    105004742 (RAF1)
   05206 MicroRNAs in cancer
    105004742 (RAF1)
   05205 Proteoglycans in cancer
    105004742 (RAF1)
   05207 Chemical carcinogenesis - receptor activation
    105004742 (RAF1)
   05208 Chemical carcinogenesis - reactive oxygen species
    105004742 (RAF1)
   05230 Central carbon metabolism in cancer
    105004742 (RAF1)
   05231 Choline metabolism in cancer
    105004742 (RAF1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    105004742 (RAF1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    105004742 (RAF1)
   05212 Pancreatic cancer
    105004742 (RAF1)
   05225 Hepatocellular carcinoma
    105004742 (RAF1)
   05226 Gastric cancer
    105004742 (RAF1)
   05214 Glioma
    105004742 (RAF1)
   05221 Acute myeloid leukemia
    105004742 (RAF1)
   05220 Chronic myeloid leukemia
    105004742 (RAF1)
   05218 Melanoma
    105004742 (RAF1)
   05211 Renal cell carcinoma
    105004742 (RAF1)
   05219 Bladder cancer
    105004742 (RAF1)
   05215 Prostate cancer
    105004742 (RAF1)
   05213 Endometrial cancer
    105004742 (RAF1)
   05224 Breast cancer
    105004742 (RAF1)
   05223 Non-small cell lung cancer
    105004742 (RAF1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    105004742 (RAF1)
   05161 Hepatitis B
    105004742 (RAF1)
   05160 Hepatitis C
    105004742 (RAF1)
   05164 Influenza A
    105004742 (RAF1)
   05163 Human cytomegalovirus infection
    105004742 (RAF1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    105004742 (RAF1)
   05165 Human papillomavirus infection
    105004742 (RAF1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    105004742 (RAF1)
   05152 Tuberculosis
    105004742 (RAF1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    105004742 (RAF1)
   05022 Pathways of neurodegeneration - multiple diseases
    105004742 (RAF1)
  09165 Substance dependence
   05034 Alcoholism
    105004742 (RAF1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    105004742 (RAF1)
   01522 Endocrine resistance
    105004742 (RAF1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:bbis01001]
    105004742 (RAF1)
Enzymes [BR:bbis01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     105004742 (RAF1)
Protein kinases [BR:bbis01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   105004742 (RAF1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr RBD C1_1 Kinase-like ABC1 zf-RING-like Pkinase_fungal C1_2
Other DBs
NCBI-GeneID: 105004742
NCBI-ProteinID: XP_010860759
Ensembl: ENSBBBG00000011493
UniProt: A0A6P3JBJ7
LinkDB
Position
Unknown
AA seq 648 aa
MEHIQGAWKTISNGFGFKDTVFDGTSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTVGDGGVPALPSLTMRRMRESVSRIPPGSQHRYSTPHAFTF
SASSPSSEGSLSQRQRSTSTPNVHMVSATLPVDSRMIEDAIRSHSESGSPSALSSSPNNL
SPTGWSQPKTPAPAQRERAPGSSTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSILWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
NT seq 1947 nt   +upstreamnt  +downstreamnt
atggagcacatacagggcgcctggaagacgatcagcaacggtttcggattcaaagacacg
gtgtttgacggcaccagctgcatctcccctacaatagttcagcaatttggctatcagcgt
cgggcgtcagatgatggcaaacttacggacccttctaagacaagcaacactatccgtgtg
tttttgccaaacaagcaaagaacagtggtcaatgtgcggaatggaatgagcttgcatgac
tgcctcatgaaagctctcaaggtgaggggcctgcaaccagagtgctgtgcagtgttcaga
cttctccacgaacacaagggtaaaaaagcacggttagattggaatactgatgctgcctcg
ttgatcggagaggaacttcaagtggatttcctggatcatgttcccctcacaacacacaac
tttgctcggaaaaccttcctgaagcttgccttctgtgacatctgtcagaagttcttgcta
aatggatttagatgtcagacttgtggctacaagtttcacgagcattgtagcaccaaagta
cccactatgtgtgtggactggagtaatatcagacagctcttattgttcccaaattccact
gttggtgatggcggggtcccagcgctgccttctttgacgatgcgtcggatgcgagagtct
gtttcccggatacctcctggttcccagcacagatattccacaccccatgctttcacattc
agcgcctccagcccctcctctgaaggctccctctcccagaggcagaggtcgacgtccacg
cccaacgtgcacatggtcagcgccaccctgcctgtggatagcaggatgatcgaggatgca
attcgaagtcacagtgaatcaggctccccttcagccttgtccagcagtcccaacaatttg
agcccaacaggctggtcacagcccaaaacccctgcgcctgcacagagagagcgggcgcca
ggctccagcacccaggagaagaacaaaattaggcctcgtggacagagagattcgagctat
tactgggaaatagaagccagtgaagtgatgctgtccactcggattggatcaggctccttt
gggactgtttataagggcaagtggcatggagacgttgcagtaaagattctgaaggtcgtt
gaccccaccccagagcagttccaggccttcaggaatgaggtggctgtcctccgcaaaacc
cggcacgtgaacatcctgctctttatggggtacatgacgaaggacaacctggcgatagtg
acccagtggtgcgagggcagcagcctctacaaacacctgcacgtccaggagaccaagttc
cagatgttccagctgattgacattgcccggcagacggctcagggaatggactatttgcat
gcaaagaacatcatccacagagacatgaaatccaataatatatttctccatgaaggcctg
acggtgaaaatcggtgattttggattggccacggtgaagtcgcgctggagtggttctcag
caggtcgagcagcccaccggctccatcctgtggatggccccagaggtgatccggatgcag
gataataacccgttcagcttccagtccgacgtctactcctacggcatcgtgctgtatgag
ctcatgacaggggagctcccttactcccacatcaacaaccgcgaccagatcatcttcatg
gtgggccgcgggtacgcctccccagacctcagcaagctatacaagaactgccccaaagcc
atgaagaggctggtagctgactgcgtgaagaaagtgaaggaagaaaggcctctttttccc
cagatcctgtcttccatcgagctgctccagcattctctgcccaagatcaaccggagtgcc
tcggagccctccctgcaccgggcggcccacaccgaggacatcaacgcctgcacgctgacc
acgtcccctcggctgcctgtcttctag

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