| Entry |
|
| Symbol |
PLCB2
|
| Name |
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1
|
| KO |
|
| Organism |
bbub Bubalus bubalis (water buffalo)
|
| Pathway |
| bbub04070 | Phosphatidylinositol signaling system |
| bbub04261 | Adrenergic signaling in cardiomyocytes |
| bbub04613 | Neutrophil extracellular trap formation |
| bbub04621 | NOD-like receptor signaling pathway |
| bbub04723 | Retrograde endocannabinoid signaling |
| bbub04750 | Inflammatory mediator regulation of TRP channels |
| bbub04925 | Aldosterone synthesis and secretion |
| bbub04928 | Parathyroid hormone synthesis, secretion and action |
| bbub04933 | AGE-RAGE signaling pathway in diabetic complications |
| bbub04935 | Growth hormone synthesis, secretion and action |
| bbub04961 | Endocrine and other factor-regulated calcium reabsorption |
| bbub04973 | Carbohydrate digestion and absorption |
| bbub05022 | Pathways of neurodegeneration - multiple diseases |
|
| Module |
| bbub_M00130 | Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 |
|
| Brite |
KEGG Orthology (KO) [BR:bbub00001]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
102389945 (PLCB2)
09130 Environmental Information Processing
09132 Signal transduction
04015 Rap1 signaling pathway
102389945 (PLCB2)
04310 Wnt signaling pathway
102389945 (PLCB2)
04371 Apelin signaling pathway
102389945 (PLCB2)
04020 Calcium signaling pathway
102389945 (PLCB2)
04070 Phosphatidylinositol signaling system
102389945 (PLCB2)
04072 Phospholipase D signaling pathway
102389945 (PLCB2)
04071 Sphingolipid signaling pathway
102389945 (PLCB2)
04022 cGMP-PKG signaling pathway
102389945 (PLCB2)
09133 Signaling molecules and interaction
04082 Neuroactive ligand signaling
102389945 (PLCB2)
04081 Hormone signaling
102389945 (PLCB2)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04540 Gap junction
102389945 (PLCB2)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
102389945 (PLCB2)
04613 Neutrophil extracellular trap formation
102389945 (PLCB2)
04621 NOD-like receptor signaling pathway
102389945 (PLCB2)
04062 Chemokine signaling pathway
102389945 (PLCB2)
09152 Endocrine system
04911 Insulin secretion
102389945 (PLCB2)
04922 Glucagon signaling pathway
102389945 (PLCB2)
04929 GnRH secretion
102389945 (PLCB2)
04912 GnRH signaling pathway
102389945 (PLCB2)
04915 Estrogen signaling pathway
102389945 (PLCB2)
04921 Oxytocin signaling pathway
102389945 (PLCB2)
04926 Relaxin signaling pathway
102389945 (PLCB2)
04935 Growth hormone synthesis, secretion and action
102389945 (PLCB2)
04918 Thyroid hormone synthesis
102389945 (PLCB2)
04919 Thyroid hormone signaling pathway
102389945 (PLCB2)
04928 Parathyroid hormone synthesis, secretion and action
102389945 (PLCB2)
04916 Melanogenesis
102389945 (PLCB2)
04924 Renin secretion
102389945 (PLCB2)
04925 Aldosterone synthesis and secretion
102389945 (PLCB2)
04927 Cortisol synthesis and secretion
102389945 (PLCB2)
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
102389945 (PLCB2)
04270 Vascular smooth muscle contraction
102389945 (PLCB2)
09154 Digestive system
04970 Salivary secretion
102389945 (PLCB2)
04971 Gastric acid secretion
102389945 (PLCB2)
04972 Pancreatic secretion
102389945 (PLCB2)
04973 Carbohydrate digestion and absorption
102389945 (PLCB2)
09155 Excretory system
04961 Endocrine and other factor-regulated calcium reabsorption
102389945 (PLCB2)
09156 Nervous system
04724 Glutamatergic synapse
102389945 (PLCB2)
04725 Cholinergic synapse
102389945 (PLCB2)
04728 Dopaminergic synapse
102389945 (PLCB2)
04726 Serotonergic synapse
102389945 (PLCB2)
04720 Long-term potentiation
102389945 (PLCB2)
04730 Long-term depression
102389945 (PLCB2)
04723 Retrograde endocannabinoid signaling
102389945 (PLCB2)
09157 Sensory system
04742 Taste transduction
102389945 (PLCB2)
04750 Inflammatory mediator regulation of TRP channels
102389945 (PLCB2)
09159 Environmental adaptation
04713 Circadian entrainment
102389945 (PLCB2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
102389945 (PLCB2)
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
102389945 (PLCB2)
09174 Infectious disease: parasitic
05146 Amoebiasis
102389945 (PLCB2)
05142 Chagas disease
102389945 (PLCB2)
05143 African trypanosomiasis
102389945 (PLCB2)
09164 Neurodegenerative disease
05010 Alzheimer disease
102389945 (PLCB2)
05016 Huntington disease
102389945 (PLCB2)
05017 Spinocerebellar ataxia
102389945 (PLCB2)
05022 Pathways of neurodegeneration - multiple diseases
102389945 (PLCB2)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
102389945 (PLCB2)
05415 Diabetic cardiomyopathy
102389945 (PLCB2)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
102389945 (PLCB2)
04934 Cushing syndrome
102389945 (PLCB2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:bbub04131]
102389945 (PLCB2)
Enzymes [BR:bbub01000]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
102389945 (PLCB2)
Membrane trafficking [BR:bbub04131]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
102389945 (PLCB2)
Endocytosis
Macropinocytosis
Phospholipase C
102389945 (PLCB2)
|
| SSDB |
|
| Motif |
|
| Other DBs |
|
| LinkDB |
|
| Position |
11:67360430..67382611
|
| AA seq |
1186 aa
MSLLNPVLLPPTVKAYLSQGERFIKWDDETTIASPVILRVDPKGYYLYWTYQSKEMELLD
ITSIRDTRFGKFAKMPKSQKLREVFNMNIPDNFLLKTLTVVSGPDMVDLTFHNFVSYKDN
VGKDWAEDVLALAKHPLTANASRSTFLDKILVKLKMQLNPEGKIPVKNFFQMFPADRKRV
EAALSACHLPKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHSKAKPYMTKEHL
AKFINQKQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINVQRGQLSPEGMVWFLCGPENS
VLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLAGCRCVELDCW
KGKPPDEEPIITHGFTMTTDIYFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKMA
EYCRTMFGDMLLTEPLEKFPLKPGIPLPSPEDLRGKILIKNKKNQFSGSASPSKEPDGEA
EGSSPPNAPVGEDTVWAGEEGAELEEEEVEEEEEESGNLDEEEIKKMQSDEGTAGLEVTA
YKEMSSLVNYIQPTKFISFEFSAQKNRSYVISSFTELKAYDLLSKSSVQFVDYNKRQMSR
IYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMR
RLDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKL
SPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPISALNSGYHHLCL
HNESNMPLTMPALFVFLEMKDYVPDTWADLTVALANPIKFFSAHDKKAVKLKEAMGGQPE
SPFPLGNHPASQVNGASAPTSNGSAAAGAKAREEATKETAEPQTASLEELQELKGVVKLQ
RRQEKELRELGRRGVRRWEELLQRGAAQLAGLGPPGAGGSGGCRGRKLGPGKGSRKKRTL
PGEDTAGAASAEGPEGEDVRLRELRDRLELELLQLGEEQCECVMKLKEQHAAQQMTKMME
LAREKQAAERKTLKETLETDTKEMKKKLEAKRLERIQAMMKVTTDKMAQERLKREINNSH
IQEVVQVIKQMTENLERHQEKLEEKQAACLEQIQEMEKQLQQEAMAEYEAKMKGLEMEVK
ESVRTYLRACFPSEEEDKSERPCVVSRELCEQDTLTEQAETQESHL |
| NT seq |
3561 nt +upstreamnt +downstreamnt
atgtctcttctcaaccctgtcctgctgccccccacggtgaaggcctatctgagccaaggg
gagcgcttcatcaaatgggatgatgaaacgacgatagcctctccagttatcctccgtgtg
gatcccaagggctactacttgtactggacatatcagagtaaggagatggagcttctggat
atcaccagcatccgggacacccgctttgggaagtttgccaagatgcccaagagccagaag
ctccgggaagtcttcaacatgaacatccccgacaacttcctgctgaagacgctcacagtg
gtatccggccctgacatggtggacctcaccttccataacttcgtctcctataaggacaac
gtgggcaaggactgggctgaagacgtactggctctggccaagcacccactgacggccaac
gcctctcgcagcaccttcctggacaagatccttgtgaagctcaagatgcagcttaaccct
gaggggaagattcccgtgaagaattttttccagatgttccctgctgaccgcaagcgggta
gaagctgccctcagcgcctgccacctccccaaaggcaagaatgatgccatcaatcctgag
gacttcccagagtccgtgtacaagagcttcctcatgagcctctgtcctcggccagaaata
gatgagatcttcacttcctaccactccaaggccaaaccctatatgactaaggagcacctg
gccaaattcatcaaccagaaacagcgcgactccaggctcaattccctgctgttcccacca
gcgcgtcctgaccaggtgcagggcctcatcgacaagtatgagcccagcggcatcaatgtg
cagcggggccagctgtcccccgagggcatggtgtggtttctctgcgggccggagaacagt
gtgctggcccaggacaagctgctgctgcaccacgacatgacccagccactcaaccattac
ttcatcaactcctcccacaacacctacctgacagccggccagttctcaggcctctcctct
gctgagatgtaccgccaggtgctgctggcaggctgccgctgcgtggagctggactgctgg
aaggggaagccccccgacgaggagcccatcatcacccatggtttcaccatgaccacagac
atctatttcaaggaagcaatcgaagccattgcagaaagtgcctttaagacctccccttat
ccggtcatcctgtcatttgaaaaccacgtggactcaccccgtcaacaggctaagatggct
gagtactgccggacgatgtttggggatatgctgctcacagaacccctggagaagttcccg
ctgaaacctggcatccccctgcccagccctgaggatctccgaggcaagatcctaatcaag
aacaagaagaaccagttttctggctctgcatcccccagcaaggagccggatggggaggct
gagggtagcagcccacccaatgcccctgtgggtgaggatacagtgtgggctggtgaggaa
ggggctgagttggaggaggaggaggtagaagaggaagaggaggagtcgggaaacctggat
gaagaagagataaagaagatgcagtcagatgagggcacagcgggcctggaggtgacggcc
tacaaggagatgtccagcctagtcaattacatccagcccaccaagttcatctccttcgag
ttctctgcccaaaagaatcgaagttatgttatctcctccttcacggagctcaaggcttac
gacctgctctccaagtcctcggtgcagtttgtggactacaacaagcgccagatgagccgc
atctaccccaagggtacccgcatggactcctccaactacatgccccagatgttctggaat
gctggttgtcagatggttgccctcaacttccagacgatggacctgcccatgcagcagaac
atggcgcttttcgagttcaacgggcagagtggctacctcctcaagcatgagttcatgcgt
cggttggacaagcagttcaatcccttctcagtggaccgcatcgacgtggtggtagccacc
accctttccattacggtgatttctgggcagttcctgtcagaacgcagcgtgcgcacctat
gtggaagtagagctgtttggccttccgggagatcccaagaggcgctatcgaaccaagctg
tcacccagtaccaactccatcaatccggtctggaaggaggagccctttgtctttgagaag
atcttgatgcctgagttggcttccctgagagttgctgtgatggaggaaggcaacaagttt
cttggacaccgcatcattcccatcagtgccctgaattctggataccaccatctctgtctg
cacaacgagagcaacatgcctctcaccatgcctgcgctcttcgtcttcctagagatgaag
gactatgtgcctgacacctgggcagatctcacagtggccctcgccaatcctatcaagttc
ttcagtgcccatgataagaaggctgtgaagctcaaggaagccatgggaggccagcccgag
agtcccttccctcttgggaaccaccctgccagccaggtcaacggggcatcggctccaaca
agcaacgggtcagcagcagccggggccaaggccagggaggaggccacgaaagaaactgcg
gaaccgcagaccgccagcctagaggagctgcaggagctgaagggcgtcgtgaagctgcag
cggcgccaggagaaggagcttcgggaactggggcggcgcggcgtgcggcgctgggaggag
ctgctgcagaggggcgcggcgcagctggccgggctcgggccgccaggcgcggggggcagc
ggcgggtgccggggccgcaagctcggcccgggcaagggatcccgcaaaaagaggaccctg
ccgggcgaggacaccgccggggcggcgtcggccgaaggccccgagggcgaggacgtgcgt
ctgcgagagctgagggacaggctggagctggagctgctgcagctgggcgaggagcaatgc
gagtgtgtcatgaagctcaaggagcagcacgcggcccagcaaatgaccaagatgatggag
ctggccagggagaaacaggctgcagaacggaagaccctcaaggagaccttggagactgac
accaaagagatgaagaagaagctggaggccaagaggctggagcggatccaggccatgatg
aaggtcaccacagacaagatggctcaggagaggttgaagagagagattaacaactcccac
attcaggaggtggtgcaggtgatcaaacagatgacggagaacctggagaggcaccaggag
aagttggaggaaaagcaggcagcctgcctggaacagatccaggagatggaaaaacagtta
cagcaggaggcgatggcagagtacgaggccaagatgaagggcctggagatggaagtgaag
gagtcagtgaggacctacctccgggcctgcttcccctctgaggaggaggacaagtctgag
agaccctgcgtggtctccagggagctgtgtgagcaggacacactcacagagcaggcagag
acccaggagagccacctctga |