KEGG   Bubalus bubalis (water buffalo): 102396307
Entry
102396307         CDS       T05912                                 
Symbol
PLCG2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
  KO
K05859  phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Organism
bbub  Bubalus bubalis (water buffalo)
Pathway
bbub00562  Inositol phosphate metabolism
bbub01100  Metabolic pathways
bbub01521  EGFR tyrosine kinase inhibitor resistance
bbub04012  ErbB signaling pathway
bbub04014  Ras signaling pathway
bbub04020  Calcium signaling pathway
bbub04062  Chemokine signaling pathway
bbub04064  NF-kappa B signaling pathway
bbub04066  HIF-1 signaling pathway
bbub04070  Phosphatidylinositol signaling system
bbub04072  Phospholipase D signaling pathway
bbub04360  Axon guidance
bbub04370  VEGF signaling pathway
bbub04380  Osteoclast differentiation
bbub04517  IgSF CAM signaling
bbub04611  Platelet activation
bbub04613  Neutrophil extracellular trap formation
bbub04625  C-type lectin receptor signaling pathway
bbub04650  Natural killer cell mediated cytotoxicity
bbub04662  B cell receptor signaling pathway
bbub04664  Fc epsilon RI signaling pathway
bbub04666  Fc gamma R-mediated phagocytosis
bbub04670  Leukocyte transendothelial migration
bbub04722  Neurotrophin signaling pathway
bbub04750  Inflammatory mediator regulation of TRP channels
bbub04919  Thyroid hormone signaling pathway
bbub04933  AGE-RAGE signaling pathway in diabetic complications
bbub04935  Growth hormone synthesis, secretion and action
bbub05167  Kaposi sarcoma-associated herpesvirus infection
bbub05169  Epstein-Barr virus infection
bbub05170  Human immunodeficiency virus 1 infection
bbub05171  Coronavirus disease - COVID-19
bbub05200  Pathways in cancer
bbub05205  Proteoglycans in cancer
bbub05206  MicroRNAs in cancer
bbub05214  Glioma
bbub05223  Non-small cell lung cancer
bbub05225  Hepatocellular carcinoma
Module
bbub_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:bbub00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    102396307 (PLCG2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    102396307 (PLCG2)
   04014 Ras signaling pathway
    102396307 (PLCG2)
   04370 VEGF signaling pathway
    102396307 (PLCG2)
   04064 NF-kappa B signaling pathway
    102396307 (PLCG2)
   04066 HIF-1 signaling pathway
    102396307 (PLCG2)
   04020 Calcium signaling pathway
    102396307 (PLCG2)
   04070 Phosphatidylinositol signaling system
    102396307 (PLCG2)
   04072 Phospholipase D signaling pathway
    102396307 (PLCG2)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    102396307 (PLCG2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    102396307 (PLCG2)
   04613 Neutrophil extracellular trap formation
    102396307 (PLCG2)
   04625 C-type lectin receptor signaling pathway
    102396307 (PLCG2)
   04650 Natural killer cell mediated cytotoxicity
    102396307 (PLCG2)
   04662 B cell receptor signaling pathway
    102396307 (PLCG2)
   04664 Fc epsilon RI signaling pathway
    102396307 (PLCG2)
   04666 Fc gamma R-mediated phagocytosis
    102396307 (PLCG2)
   04670 Leukocyte transendothelial migration
    102396307 (PLCG2)
   04062 Chemokine signaling pathway
    102396307 (PLCG2)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    102396307 (PLCG2)
   04919 Thyroid hormone signaling pathway
    102396307 (PLCG2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    102396307 (PLCG2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    102396307 (PLCG2)
  09158 Development and regeneration
   04360 Axon guidance
    102396307 (PLCG2)
   04380 Osteoclast differentiation
    102396307 (PLCG2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102396307 (PLCG2)
   05206 MicroRNAs in cancer
    102396307 (PLCG2)
   05205 Proteoglycans in cancer
    102396307 (PLCG2)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    102396307 (PLCG2)
   05214 Glioma
    102396307 (PLCG2)
   05223 Non-small cell lung cancer
    102396307 (PLCG2)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    102396307 (PLCG2)
   05171 Coronavirus disease - COVID-19
    102396307 (PLCG2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102396307 (PLCG2)
   05169 Epstein-Barr virus infection
    102396307 (PLCG2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    102396307 (PLCG2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102396307 (PLCG2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:bbub04131]
    102396307 (PLCG2)
Enzymes [BR:bbub01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     102396307 (PLCG2)
Membrane trafficking [BR:bbub04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    102396307 (PLCG2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    102396307 (PLCG2)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 C2 SH3_1 SH3_9 PH PH_12 EF-hand_PLCG1 SH2_1 SH3_2 PH_14 GDPD EF-hand_like
Other DBs
NCBI-GeneID: 102396307
NCBI-ProteinID: XP_044787843
LinkDB
Position
18:7993372..8157921
AA seq 1416 aa
MAASTWKRVMKKNTIILEDWDLGQAGGSPPAASVSSSARGGAVPRLARPRGGSTRRPGCS
EQRAALGPPRGRGWGGPGRRGRPRRSHVARGRGRRRSSSARVGGRARQGVPGVWTAGGCA
RDPEPGPAAGARPASLFTLFLLASRAGQQTTASTMANVDTLPEYEKSQIKRALELGTVMT
VFSFRKSTPERRTVQVIMETRQVAWSKTADKIEGFLDIMEIKEIRPGKSSKDFERAKAVR
QKEECCFTVLYGTQFILSTLSLAADSKEDATKWLSGLKILHQEVMGAPTPTIIESWLRKQ
IYSVDQTRRNSISLRELKTILPLVNFKVSSAKFLKDKFLEIGAHKDELSFEQFHLFYKKL
MFEQQKSILDEFKKDSSVFLLGNTDRPDASAVHLHDFQRFLLHEQQELWAQDLNKVRERM
TKFIDDTMRETAEPFLFVDEFLTYLFSRENSIWDEKYDVVDMQDMNNPLSHYWISSSHNT
YLTGDQLRSESSTEAYIRCLRMGCRCIELDCWDGPDGKPIIYHGWTRTTKIKFDDVVQAI
KDHAFVTSSFPVILSIEEHCCVEQQRHMARVFKEVLGDLLLTKPKEASADQLPSPSQLRG
KIIIKHKKLGPRGDVDVNMEDKKDEHKQQGELHMWDPIDQKWTRHYCAVADAKLSFSDDI
EQTVEEELPLDIPPTELHFGEKWFHKKVEKRTSAEKLLQEYCAETGGKDGTFLVRESETF
PNDYTLSFWRSGRVQHCRIRSTMEGGAMKYYLTDNLMFTSIYALIQHYRETHLRCAEFEL
RLTDPVPNPNPHESKPWYYDGLSRGEAEDMLMRIPRDGAFLIRKREGTESYAITFRARGK
VKHCRINRDGRHFVLGTSAYFESLVELVSYYEKHALYRKMKLRYPVTPELLERYNMERDI
NSLYDVSRMYVDPSEINPSMPQRTVKALYDYRAKQSDELSFCRGALIHNVSKEPGGWWKG
DYGTRIQQYFPSNYVEDISPTEGEEVDKQIIEDNPLGSLCRGILNLNIYNVVKAPHGKNQ
KPFVFILEPKKQGDPPVEFATDSVEELFEWFQSIREITWKMDTKENNMKYWEKNQSIAIE
LSDLVVYCKPTSKTKDNLENPDFREIRSFVETKADSIVRQKPSDLLKYNQKGLTRVYPKG
QRVDSSNYDPFRLWLCGSQMVALNFQTPDKYMQMNHALFSLNGRTGYVLQPESMRAEKYD
PMPPESQRKIQMTLTVKVLGARHLPKPGRSIACPFVEVEICGAEYDSNKFKTTVVNDNGL
SPVWTPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKGIKSGFRSVPLKN
GYSEDIELASLLVFCEMRPVLESEEELYSSCRQLRRRQEELNNQLFLYDTHQNLRSATRD
ALVREFNVNENQLQLYQEKCNRRLREKRVSNSKFYS
NT seq 4251 nt   +upstreamnt  +downstreamnt
atggctgctagcacatggaagagggttatgaagaaaaacacgatcatccttgaggactgg
gacctggggcaggcaggtggatcccctcccgcagcctcagtttcttcctcggcccgcgga
ggcgcggtcccgaggctggcccgccctcggggagggagcacgcggcgccccgggtgctct
gagcaaagggcggcgctgggcccgcctcggggccgggggtggggcgggccggggcgcagg
gggcggccccggaggagtcacgtggcgcgtggccgcggccgaaggagaagtagcagcgcc
cgcgtcggagggcgtgcgcggcagggagtacccggagtctggacagcgggcggctgcgcg
cgggacccggagcccggacccgcggcgggggcgcggccagcctccttgttcaccctcttc
ctcctcgcctcccgcgctgggcagcagacgacggcgagcaccatggccaacgtggacacc
ctcccggagtacgagaagagtcagatcaagcgggccctggagctgggcaccgtcatgacc
gtgttcagcttccgcaagtccaccccagagcggaggaccgtccaggtgatcatggagacg
cggcaggtggcctggagcaagacggccgacaagatcgagggcttcctggacatcatggag
ataaaggagatccggccagggaagagctccaaggatttcgagcgcgcgaaagcagtccgc
cagaaggaagagtgctgcttcaccgtcctgtacggcacccagtttatcctcagcacgctc
agccttgcagccgactcgaaggaggatgcaactaagtggctgtctggcctgaagatctta
caccaggaagtgatgggcgcgcccacccccaccatcatcgagagctggctgagaaagcag
atttattctgtggatcaaaccaggagaaacagcatcagcctccgggagttgaagaccatc
ttgcccctggtcaacttcaaagtgagcagtgccaagttcctcaaagataagttcctggaa
ataggcgcacacaaagatgaactcagctttgaacagttccatctcttctataaaaaactt
atgtttgaacagcaaaaatcgatccttgacgagttcaaaaaggattcttctgtgttcctc
ttgggcaacaccgaccggccggacgcctctgctgtccacctgcacgacttccagcggttt
ctcttgcatgaacagcaggagctttgggctcaggatctgaacaaagtccgtgagcggatg
acgaagtttattgacgacaccatgagggaaactgctgaacccttcctgtttgtggatgag
ttcctcacgtacctgttttcccgggagaatagcatctgggatgagaagtatgacgtggtg
gacatgcaggacatgaacaaccccttgtctcattactggatctcctcgtctcacaacacg
tacctcacgggggaccagctgcggagcgagtcgtccacggaggcctacatccgctgcctg
cggatgggctgccgctgcatcgagctggactgctgggatgggcccgatggcaagcccatc
atctaccacggctggacgcggaccaccaagatcaagttcgacgacgttgtgcaggccatc
aaagaccatgcctttgtcacctccagcttccccgtgatcctgtccatcgaggagcactgc
tgtgtggagcagcagcgccacatggccagggtgttcaaggaggtgcttggagacctgctg
ctgaccaaacccaaggaggccagtgccgaccagctgccgtcgcccagccagctgcgcggg
aagatcatcatcaagcataagaagctgggcccccgcggcgatgtggacgtcaacatggag
gacaagaaggacgagcacaagcagcagggcgaactgcacatgtgggaccccatcgaccag
aaatggactcggcactattgtgccgttgctgatgccaagctgtccttcagcgatgacatt
gaacagactgtggaagaggagctgcccctggatatacccccaacagagctgcattttggg
gagaagtggttccacaagaaggtggagaagaggacaagtgccgagaagctgctgcaggaa
tactgcgccgagacagggggcaaggatgggaccttcttggtgcgggagagtgagaccttc
cccaacgactacaccctgtccttctggcggtcgggccgcgtgcagcactgccggatccgc
tccaccatggagggcggggccatgaagtactacctgaccgacaacctcatgttcaccagc
atctacgccctcatccagcactaccgcgagacacacctgcgctgcgccgagttcgagctc
cggctgaccgaccccgtgcccaaccccaacccgcacgagtccaagccgtggtactacgat
gggctgagccgtggagaagcggaggacatgctgatgcggatcccccgggacggggccttc
ctgatccggaagcgggaaggtaccgagtcctacgccatcaccttcagggccaggggcaag
gtgaagcactgccgcatcaaccgagacggccggcacttcgtgctgggcacctccgcctac
ttcgagagccttgtggagctggtcagctactacgagaagcacgcgctctaccggaagatg
aaactgcgctaccccgtgacccccgagctcctggagcgctacaacatggaaagagatata
aactccctctatgatgtcagcaggatgtatgtggatcccagtgaaatcaatccttcaatg
cctcagagaaccgtgaaagctctgtatgactacagggccaagcagagtgacgagctgagc
ttttgccgcggtgccctcatccacaacgtctccaaggagcctgggggctggtggaaagga
gactatgggaccagaatccagcagtacttcccgtccaattacgttgaggacatatcacca
acagaaggggaggaggtggataagcagattattgaagacaatcccttagggtccctttgc
agaggaatcctgaatctcaacatctataatgttgtaaaagccccacatgggaagaaccag
aagcctttcgtctttatcttggagcccaagaagcagggcgaccctccggtagagtttgcc
acggacagcgtggaggagctgtttgagtggttccagagcatccgggagatcacctggaag
atggacaccaaggagaacaacatgaagtactgggagaagaaccagtccatcgccatcgag
ctctcggacctggtcgtctactgcaagccaaccagcaagaccaaggacaacctcgaaaac
cctgacttccgagaaatccgctcctttgtggagacgaaggctgacagtatcgtcagacag
aagcccagcgatctcctgaaatacaatcaaaagggcctgacccgtgtgtaccccaaagga
cagcgggtggactcgtccaactatgaccccttccgcctctggctgtgcggctcccagatg
gtggcgctcaatttccagactccagataagtacatgcagatgaaccacgccctgttctcc
ctcaacgggcggacgggctacgtcctgcagcctgagagcatgagggcggagaagtacgac
cccatgccacccgagtcccagaggaagatccagatgaccctgacggtcaaggtgctgggg
gcccgtcaccttcccaagcccggccgcagcatcgcgtgcccctttgtggaggtggagata
tgcggagcggagtacgacagcaacaagtttaagacgacggttgtgaatgacaatggcctc
agccctgtttggaccccaacgcaggagaaggtgacgtttgagatttatgaccccaacctt
gcgtttctgcgctttgtggtttatgaggaagatatgttcagcgatcccaactttctggcc
catgccacgtaccccattaaaggaatcaagtcaggatttagatctgttcctctgaagaac
ggctacagcgaagacattgagctggcatccctcctggttttctgtgagatgcggccagtc
ctggagagcgaagaggagctgtattcctcctgccgccagctgcggaggcggcaagaagaa
ctgaacaaccagctctttctgtacgacacccaccagaacctgcgcagcgccacccgcgat
gccctggtcagagaattcaacgttaacgagaaccagctgcagctgtaccaggagaagtgc
aaccgcaggttaagagagaagagagtcagcaacagcaagttttactcatag

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