KEGG   Bubalus bubalis (water buffalo): 102396842
Entry
102396842         CDS       T05912                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1 isoform X1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
bbub  Bubalus bubalis (water buffalo)
Pathway
bbub01521  EGFR tyrosine kinase inhibitor resistance
bbub01522  Endocrine resistance
bbub04010  MAPK signaling pathway
bbub04012  ErbB signaling pathway
bbub04014  Ras signaling pathway
bbub04015  Rap1 signaling pathway
bbub04022  cGMP-PKG signaling pathway
bbub04024  cAMP signaling pathway
bbub04062  Chemokine signaling pathway
bbub04066  HIF-1 signaling pathway
bbub04068  FoxO signaling pathway
bbub04071  Sphingolipid signaling pathway
bbub04072  Phospholipase D signaling pathway
bbub04114  Oocyte meiosis
bbub04140  Autophagy - animal
bbub04148  Efferocytosis
bbub04150  mTOR signaling pathway
bbub04151  PI3K-Akt signaling pathway
bbub04210  Apoptosis
bbub04218  Cellular senescence
bbub04270  Vascular smooth muscle contraction
bbub04370  VEGF signaling pathway
bbub04371  Apelin signaling pathway
bbub04380  Osteoclast differentiation
bbub04510  Focal adhesion
bbub04517  IgSF CAM signaling
bbub04540  Gap junction
bbub04550  Signaling pathways regulating pluripotency of stem cells
bbub04613  Neutrophil extracellular trap formation
bbub04620  Toll-like receptor signaling pathway
bbub04650  Natural killer cell mediated cytotoxicity
bbub04660  T cell receptor signaling pathway
bbub04662  B cell receptor signaling pathway
bbub04664  Fc epsilon RI signaling pathway
bbub04666  Fc gamma R-mediated phagocytosis
bbub04668  TNF signaling pathway
bbub04720  Long-term potentiation
bbub04722  Neurotrophin signaling pathway
bbub04725  Cholinergic synapse
bbub04726  Serotonergic synapse
bbub04730  Long-term depression
bbub04810  Regulation of actin cytoskeleton
bbub04910  Insulin signaling pathway
bbub04912  GnRH signaling pathway
bbub04914  Progesterone-mediated oocyte maturation
bbub04915  Estrogen signaling pathway
bbub04916  Melanogenesis
bbub04917  Prolactin signaling pathway
bbub04919  Thyroid hormone signaling pathway
bbub04921  Oxytocin signaling pathway
bbub04926  Relaxin signaling pathway
bbub04928  Parathyroid hormone synthesis, secretion and action
bbub04929  GnRH secretion
bbub04934  Cushing syndrome
bbub04935  Growth hormone synthesis, secretion and action
bbub05010  Alzheimer disease
bbub05022  Pathways of neurodegeneration - multiple diseases
bbub05034  Alcoholism
bbub05132  Salmonella infection
bbub05135  Yersinia infection
bbub05160  Hepatitis C
bbub05161  Hepatitis B
bbub05163  Human cytomegalovirus infection
bbub05164  Influenza A
bbub05165  Human papillomavirus infection
bbub05166  Human T-cell leukemia virus 1 infection
bbub05167  Kaposi sarcoma-associated herpesvirus infection
bbub05170  Human immunodeficiency virus 1 infection
bbub05200  Pathways in cancer
bbub05205  Proteoglycans in cancer
bbub05206  MicroRNAs in cancer
bbub05207  Chemical carcinogenesis - receptor activation
bbub05208  Chemical carcinogenesis - reactive oxygen species
bbub05210  Colorectal cancer
bbub05211  Renal cell carcinoma
bbub05212  Pancreatic cancer
bbub05213  Endometrial cancer
bbub05214  Glioma
bbub05215  Prostate cancer
bbub05216  Thyroid cancer
bbub05218  Melanoma
bbub05219  Bladder cancer
bbub05220  Chronic myeloid leukemia
bbub05221  Acute myeloid leukemia
bbub05223  Non-small cell lung cancer
bbub05224  Breast cancer
bbub05225  Hepatocellular carcinoma
bbub05226  Gastric cancer
bbub05230  Central carbon metabolism in cancer
bbub05231  Choline metabolism in cancer
bbub05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:bbub00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    102396842 (MAP2K1)
   04012 ErbB signaling pathway
    102396842 (MAP2K1)
   04014 Ras signaling pathway
    102396842 (MAP2K1)
   04015 Rap1 signaling pathway
    102396842 (MAP2K1)
   04370 VEGF signaling pathway
    102396842 (MAP2K1)
   04371 Apelin signaling pathway
    102396842 (MAP2K1)
   04668 TNF signaling pathway
    102396842 (MAP2K1)
   04066 HIF-1 signaling pathway
    102396842 (MAP2K1)
   04068 FoxO signaling pathway
    102396842 (MAP2K1)
   04072 Phospholipase D signaling pathway
    102396842 (MAP2K1)
   04071 Sphingolipid signaling pathway
    102396842 (MAP2K1)
   04024 cAMP signaling pathway
    102396842 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    102396842 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    102396842 (MAP2K1)
   04150 mTOR signaling pathway
    102396842 (MAP2K1)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    102396842 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    102396842 (MAP2K1)
   04148 Efferocytosis
    102396842 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    102396842 (MAP2K1)
   04210 Apoptosis
    102396842 (MAP2K1)
   04218 Cellular senescence
    102396842 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    102396842 (MAP2K1)
   04540 Gap junction
    102396842 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    102396842 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    102396842 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    102396842 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    102396842 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    102396842 (MAP2K1)
   04660 T cell receptor signaling pathway
    102396842 (MAP2K1)
   04662 B cell receptor signaling pathway
    102396842 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    102396842 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    102396842 (MAP2K1)
   04062 Chemokine signaling pathway
    102396842 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    102396842 (MAP2K1)
   04929 GnRH secretion
    102396842 (MAP2K1)
   04912 GnRH signaling pathway
    102396842 (MAP2K1)
   04915 Estrogen signaling pathway
    102396842 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    102396842 (MAP2K1)
   04917 Prolactin signaling pathway
    102396842 (MAP2K1)
   04921 Oxytocin signaling pathway
    102396842 (MAP2K1)
   04926 Relaxin signaling pathway
    102396842 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    102396842 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    102396842 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    102396842 (MAP2K1)
   04916 Melanogenesis
    102396842 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    102396842 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    102396842 (MAP2K1)
   04726 Serotonergic synapse
    102396842 (MAP2K1)
   04720 Long-term potentiation
    102396842 (MAP2K1)
   04730 Long-term depression
    102396842 (MAP2K1)
   04722 Neurotrophin signaling pathway
    102396842 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    102396842 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102396842 (MAP2K1)
   05206 MicroRNAs in cancer
    102396842 (MAP2K1)
   05205 Proteoglycans in cancer
    102396842 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    102396842 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    102396842 (MAP2K1)
   05230 Central carbon metabolism in cancer
    102396842 (MAP2K1)
   05231 Choline metabolism in cancer
    102396842 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102396842 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    102396842 (MAP2K1)
   05212 Pancreatic cancer
    102396842 (MAP2K1)
   05225 Hepatocellular carcinoma
    102396842 (MAP2K1)
   05226 Gastric cancer
    102396842 (MAP2K1)
   05214 Glioma
    102396842 (MAP2K1)
   05216 Thyroid cancer
    102396842 (MAP2K1)
   05221 Acute myeloid leukemia
    102396842 (MAP2K1)
   05220 Chronic myeloid leukemia
    102396842 (MAP2K1)
   05218 Melanoma
    102396842 (MAP2K1)
   05211 Renal cell carcinoma
    102396842 (MAP2K1)
   05219 Bladder cancer
    102396842 (MAP2K1)
   05215 Prostate cancer
    102396842 (MAP2K1)
   05213 Endometrial cancer
    102396842 (MAP2K1)
   05224 Breast cancer
    102396842 (MAP2K1)
   05223 Non-small cell lung cancer
    102396842 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    102396842 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    102396842 (MAP2K1)
   05161 Hepatitis B
    102396842 (MAP2K1)
   05160 Hepatitis C
    102396842 (MAP2K1)
   05164 Influenza A
    102396842 (MAP2K1)
   05163 Human cytomegalovirus infection
    102396842 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102396842 (MAP2K1)
   05165 Human papillomavirus infection
    102396842 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    102396842 (MAP2K1)
   05135 Yersinia infection
    102396842 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102396842 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    102396842 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    102396842 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    102396842 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102396842 (MAP2K1)
   01522 Endocrine resistance
    102396842 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:bbub01001]
    102396842 (MAP2K1)
Enzymes [BR:bbub01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     102396842 (MAP2K1)
Protein kinases [BR:bbub01001]
 Serine/threonine kinases: STE group
  STE7 family
   102396842 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7
Other DBs
NCBI-GeneID: 102396842
NCBI-ProteinID: XP_006050282
LinkDB
Position
11:complement(89483834..89557338)
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggccccggacggctccgcggtt
aacgggaccagctcggcggagaccaacctggaggccttgcagaagaagctggaggagctg
gagctcgatgaacagcagcggaagcgcctcgaggcctttctgacccagaagcagaaggtg
ggggaactgaaggatgatgactttgagaagatcagtgagctgggtgccggcaatggaggt
gtggtgttcaaggtctcccacaagccgtccggactcgttatggccagaaagctaattcac
ctggagatcaaacctgccatccggaaccagatcataagggagctgcaggttctccatgag
tgcaactcgccttacatcgtgggcttctacggggcgttctacagcgacggcgagatcagc
atctgcatggagcacatggatgggggttccttggatcaagttctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaataaaaggcctgacatacctg
agggagaagcacaagattatgcacagagatgtcaagccgtccaacatcctagtgaacagc
cgtggagagatcaagctctgtgactttggggtcagcgggcagctcatcgactccatggcc
aactccttcgtgggcaccaggtcctacatgtcgccagagcgactccaggggacccattac
tccgtgcagtcggacatctggagcatggggctctctctggttgagatggctgtcgggagg
tatcccatccctcctccagatgccaaggagctggagctgatgtttgggtgccaggtggag
ggagatgcggctgagaccccgcccaggccaaggacccccgggaggcccctcagctcttat
ggaatggacagccgacctccaatggcaatttttgagttgttggattacatagtcaatgag
cctcctccaaaactgcccagtggagtattcagtctggaatttcaagattttgtgaataaa
tgcttaataaaaaaccccgcagagagagcagatttgaagcaactcatggttcatgctttt
atcaagagatctgatgctgaggaagtggattttgcaggttggctctgctccaccatcggc
cttaaccagcccagcacacccacccatgcggctggcgtctaa

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