KEGG   Bubalus bubalis (water buffalo): 102400519
Entry
102400519         CDS       T05912                                 
Symbol
PIK3CA
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
bbub  Bubalus bubalis (water buffalo)
Pathway
bbub00562  Inositol phosphate metabolism
bbub01100  Metabolic pathways
bbub01521  EGFR tyrosine kinase inhibitor resistance
bbub01522  Endocrine resistance
bbub01524  Platinum drug resistance
bbub04012  ErbB signaling pathway
bbub04014  Ras signaling pathway
bbub04015  Rap1 signaling pathway
bbub04024  cAMP signaling pathway
bbub04062  Chemokine signaling pathway
bbub04066  HIF-1 signaling pathway
bbub04068  FoxO signaling pathway
bbub04070  Phosphatidylinositol signaling system
bbub04071  Sphingolipid signaling pathway
bbub04072  Phospholipase D signaling pathway
bbub04081  Hormone signaling
bbub04140  Autophagy - animal
bbub04145  Phagocytosis
bbub04150  mTOR signaling pathway
bbub04151  PI3K-Akt signaling pathway
bbub04152  AMPK signaling pathway
bbub04210  Apoptosis
bbub04211  Longevity regulating pathway
bbub04213  Longevity regulating pathway - multiple species
bbub04218  Cellular senescence
bbub04360  Axon guidance
bbub04370  VEGF signaling pathway
bbub04380  Osteoclast differentiation
bbub04510  Focal adhesion
bbub04517  IgSF CAM signaling
bbub04518  Integrin signaling
bbub04550  Signaling pathways regulating pluripotency of stem cells
bbub04611  Platelet activation
bbub04613  Neutrophil extracellular trap formation
bbub04620  Toll-like receptor signaling pathway
bbub04625  C-type lectin receptor signaling pathway
bbub04630  JAK-STAT signaling pathway
bbub04650  Natural killer cell mediated cytotoxicity
bbub04660  T cell receptor signaling pathway
bbub04662  B cell receptor signaling pathway
bbub04664  Fc epsilon RI signaling pathway
bbub04666  Fc gamma R-mediated phagosome formation
bbub04668  TNF signaling pathway
bbub04670  Leukocyte transendothelial migration
bbub04722  Neurotrophin signaling pathway
bbub04725  Cholinergic synapse
bbub04750  Inflammatory mediator regulation of TRP channels
bbub04810  Regulation of actin cytoskeleton
bbub04910  Insulin signaling pathway
bbub04914  Progesterone-mediated oocyte maturation
bbub04915  Estrogen signaling pathway
bbub04917  Prolactin signaling pathway
bbub04919  Thyroid hormone signaling pathway
bbub04923  Regulation of lipolysis in adipocytes
bbub04926  Relaxin signaling pathway
bbub04929  GnRH secretion
bbub04930  Type II diabetes mellitus
bbub04931  Insulin resistance
bbub04932  Non-alcoholic fatty liver disease
bbub04933  AGE-RAGE signaling pathway in diabetic complications
bbub04935  Growth hormone synthesis, secretion and action
bbub04960  Aldosterone-regulated sodium reabsorption
bbub04973  Carbohydrate digestion and absorption
bbub05010  Alzheimer disease
bbub05017  Spinocerebellar ataxia
bbub05020  Prion disease
bbub05100  Bacterial invasion of epithelial cells
bbub05132  Salmonella infection
bbub05135  Yersinia infection
bbub05142  Chagas disease
bbub05146  Amoebiasis
bbub05160  Hepatitis C
bbub05161  Hepatitis B
bbub05162  Measles
bbub05163  Human cytomegalovirus infection
bbub05164  Influenza A
bbub05165  Human papillomavirus infection
bbub05166  Human T-cell leukemia virus 1 infection
bbub05167  Kaposi sarcoma-associated herpesvirus infection
bbub05168  Herpes simplex virus 1 infection
bbub05169  Epstein-Barr virus infection
bbub05170  Human immunodeficiency virus 1 infection
bbub05171  Coronavirus disease
bbub05200  Pathways in cancer
bbub05203  Viral carcinogenesis
bbub05205  Proteoglycans in cancer
bbub05206  MicroRNAs in cancer
bbub05207  Chemical carcinogenesis - receptor activation
bbub05208  Chemical carcinogenesis - reactive oxygen species
bbub05210  Colorectal cancer
bbub05211  Renal cell carcinoma
bbub05212  Pancreatic cancer
bbub05213  Endometrial cancer
bbub05214  Glioma
bbub05215  Prostate cancer
bbub05218  Melanoma
bbub05220  Chronic myeloid leukemia
bbub05221  Acute myeloid leukemia
bbub05222  Small cell lung cancer
bbub05223  Non-small cell lung cancer
bbub05224  Breast cancer
bbub05225  Hepatocellular carcinoma
bbub05226  Gastric cancer
bbub05230  Central carbon metabolism in cancer
bbub05231  Choline metabolism in cancer
bbub05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
bbub05415  Diabetic cardiomyopathy
bbub05417  Lipid and atherosclerosis
bbub05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:bbub00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    102400519 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    102400519 (PIK3CA)
   04014 Ras signaling pathway
    102400519 (PIK3CA)
   04015 Rap1 signaling pathway
    102400519 (PIK3CA)
   04370 VEGF signaling pathway
    102400519 (PIK3CA)
   04630 JAK-STAT signaling pathway
    102400519 (PIK3CA)
   04668 TNF signaling pathway
    102400519 (PIK3CA)
   04066 HIF-1 signaling pathway
    102400519 (PIK3CA)
   04068 FoxO signaling pathway
    102400519 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    102400519 (PIK3CA)
   04072 Phospholipase D signaling pathway
    102400519 (PIK3CA)
   04071 Sphingolipid signaling pathway
    102400519 (PIK3CA)
   04024 cAMP signaling pathway
    102400519 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    102400519 (PIK3CA)
   04152 AMPK signaling pathway
    102400519 (PIK3CA)
   04150 mTOR signaling pathway
    102400519 (PIK3CA)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    102400519 (PIK3CA)
   04517 IgSF CAM signaling
    102400519 (PIK3CA)
   04518 Integrin signaling
    102400519 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    102400519 (PIK3CA)
   04140 Autophagy - animal
    102400519 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    102400519 (PIK3CA)
   04218 Cellular senescence
    102400519 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    102400519 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    102400519 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    102400519 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    102400519 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    102400519 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    102400519 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    102400519 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    102400519 (PIK3CA)
   04660 T cell receptor signaling pathway
    102400519 (PIK3CA)
   04662 B cell receptor signaling pathway
    102400519 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    102400519 (PIK3CA)
   04666 Fc gamma R-mediated phagosome formation
    102400519 (PIK3CA)
   04670 Leukocyte transendothelial migration
    102400519 (PIK3CA)
   04062 Chemokine signaling pathway
    102400519 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    102400519 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    102400519 (PIK3CA)
   04929 GnRH secretion
    102400519 (PIK3CA)
   04915 Estrogen signaling pathway
    102400519 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    102400519 (PIK3CA)
   04917 Prolactin signaling pathway
    102400519 (PIK3CA)
   04926 Relaxin signaling pathway
    102400519 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    102400519 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    102400519 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    102400519 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    102400519 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    102400519 (PIK3CA)
   04722 Neurotrophin signaling pathway
    102400519 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    102400519 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    102400519 (PIK3CA)
   04380 Osteoclast differentiation
    102400519 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    102400519 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    102400519 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102400519 (PIK3CA)
   05206 MicroRNAs in cancer
    102400519 (PIK3CA)
   05205 Proteoglycans in cancer
    102400519 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    102400519 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    102400519 (PIK3CA)
   05203 Viral carcinogenesis
    102400519 (PIK3CA)
   05230 Central carbon metabolism in cancer
    102400519 (PIK3CA)
   05231 Choline metabolism in cancer
    102400519 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102400519 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    102400519 (PIK3CA)
   05212 Pancreatic cancer
    102400519 (PIK3CA)
   05225 Hepatocellular carcinoma
    102400519 (PIK3CA)
   05226 Gastric cancer
    102400519 (PIK3CA)
   05214 Glioma
    102400519 (PIK3CA)
   05221 Acute myeloid leukemia
    102400519 (PIK3CA)
   05220 Chronic myeloid leukemia
    102400519 (PIK3CA)
   05218 Melanoma
    102400519 (PIK3CA)
   05211 Renal cell carcinoma
    102400519 (PIK3CA)
   05215 Prostate cancer
    102400519 (PIK3CA)
   05213 Endometrial cancer
    102400519 (PIK3CA)
   05224 Breast cancer
    102400519 (PIK3CA)
   05222 Small cell lung cancer
    102400519 (PIK3CA)
   05223 Non-small cell lung cancer
    102400519 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    102400519 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    102400519 (PIK3CA)
   05161 Hepatitis B
    102400519 (PIK3CA)
   05160 Hepatitis C
    102400519 (PIK3CA)
   05171 Coronavirus disease
    102400519 (PIK3CA)
   05164 Influenza A
    102400519 (PIK3CA)
   05162 Measles
    102400519 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    102400519 (PIK3CA)
   05163 Human cytomegalovirus infection
    102400519 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102400519 (PIK3CA)
   05169 Epstein-Barr virus infection
    102400519 (PIK3CA)
   05165 Human papillomavirus infection
    102400519 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    102400519 (PIK3CA)
   05135 Yersinia infection
    102400519 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    102400519 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    102400519 (PIK3CA)
   05142 Chagas disease
    102400519 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102400519 (PIK3CA)
   05017 Spinocerebellar ataxia
    102400519 (PIK3CA)
   05020 Prion disease
    102400519 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    102400519 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    102400519 (PIK3CA)
   05415 Diabetic cardiomyopathy
    102400519 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    102400519 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    102400519 (PIK3CA)
   04931 Insulin resistance
    102400519 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    102400519 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102400519 (PIK3CA)
   01524 Platinum drug resistance
    102400519 (PIK3CA)
   01522 Endocrine resistance
    102400519 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:bbub04131]
    102400519 (PIK3CA)
Enzymes [BR:bbub01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     102400519 (PIK3CA)
Membrane trafficking [BR:bbub04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    102400519 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 102400519
NCBI-ProteinID: XP_044800428
LinkDB
Position
1:complement(133241140..133330041)
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatgggatgatagtgactttagaatgcctccgtgaggct
acgttaataacgataaagcatgaactatttaaagaagcaagaaaataccctctccatcaa
cttcttcaagatgaatcgtcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctttttcaaccctttttaaaa
gtaattgaaccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgct
atcggcatgccagtgtgtgaattcgatatggttaaagatccagaagtacaggacttccga
aggaatattctcaatgtttgtaaagaagctgtggatcttagggatcttaattcacctcat
agtagagcaatgtatgtttatcctccaaatgtagaatcttcaccagaactgccaaagcac
atatataataaattggataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaaacagaagtatactctgaaaatcaaccatgactgtgtgccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttgctatcatctgaacaactaaaa
ctctgtgttttagaatatcagggcaagtatattttaaaagtgtgtggatgtgatgaatac
ttcctagaaaaatatcctctgagtcagtataagtatataagaagctgtataatgcttggg
aggatgcccaatttgatgctgatggctaaagaaagcctctattctcaactgccaatggac
tgttttacaatgccatcatattccagacgcatctccacagctacgccatatatgaatgga
gaaacatctacaaaatccctttgggttataaatagtgcactcagaataaaaattctttgt
gcaacctatgtgaatgtaaatattcgagacattgacaagatttatgttcgaacaggtatc
taccatggaggagaacccttatgtgataatgtgaacactcaaagagtaccttgttccaat
cccaggtggaatgaatggctgaattacgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgttctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcctggggaaatataaacttgtttgattacacagatactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggactagaagatttgctgaaccctattggt
gttactggatcaaatccaaataaagaaactccatgtttagagttggagtttgactggttc
agcagtgtggtaaagtttcccgatatgtcagtgattgaagagcatgccaattggtctgta
tcccgtgaagcaggatttagttattctcatgcaggactgagtaacagactagctagagac
aatgaattaagagaaaatgataaagaacagctccgagcaatttgtacacgagatcctcta
tctgaaatcactgagcaagagaaagattttctgtggagccacagacactattgtgtaact
atccccgaaattctacccaaattgcttctgtctgttaaatggaactctagagatgaagta
gctcagatgtactgcttggtaaaagattggcctccaatcaagcctgaacaggctatggag
cttctggactgcaattacccagatcctatggttcgaggttttgctgttcggtgcttagaa
aaatatttaacagatgacaaactttctcagtacctaattcagctagtacaggtactaaaa
tatgaacagtatttggataacctgcttgtgagatttttactcaaaaaagcgttaactaat
caaaggatcggtcactttttcttttggcatttaaaatctgagatgcacaataaaacagtt
agtcagaggtttggcctgcttttggagtcctattgccgtgcatgtgggatgtatctgaag
caccttaataggcaagttgaggctatggaaaagctcattaacttgactgacattctcaaa
caagagaagaaggatgaaacacaaaaggtacagatgaagtttttagttgagcaaatgcgg
cgaccagatttcatggatgctctccagggctttctgtctcctctaaaccctgctcatcag
ctgggaaatctcaggcttgaagagtgtcgaattatgtcttctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactctttcagaacaatgagatcatc
tttaaaaatggggatgatttacggcaagatatgctaacccttcagattattcgcattatg
gaaaatatctggcaaaatcaaggtcttgatcttcgaatgttaccttatggatgtctgtca
attggtgactgtgtgggacttatcgaggtggtgagaaattctcacactataatgcagatt
cagtgtaaaggaggcctgaaaggtgcactgcagttcaacagccacacactccatcagtgg
ctcaaagacaagaacaagggagagatatatgatgcagccatcgatttgtttacacgatca
tgtgctggatattgtgttgccaccttcattttgggaattggagatcgtcacaatagtaat
atcatggttaaagatgatggacaactgtttcatatagattttggacactttttggatcac
aagaagaaaaaatttggttataaacgagagcgcgtgccgtttgttttgacacaagatttc
ttaatagtgattagtaaaggagcccaagaatgcacaaagacaagagaatttgagaggttt
caggagatgtgttacaaggcttatctagctattcggcagcatgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactacaatcttttgatgatattgca
tacattcgaaagaccctagctttagataaaactgagcaagaggctttggaatatttcatg
aaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccac
acaattaagcagcatgctttgaactga

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