Bubalus bubalis (water buffalo): 102401126
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Entry
102401126 CDS
T05912
Symbol
KMT2A
Name
(RefSeq) histone-lysine N-methyltransferase 2A isoform X10
KO
K09186
[histone H3]-lysine4 N-trimethyltransferase MLL1 [EC:
2.1.1.354
]
Organism
bbub
Bubalus bubalis (water buffalo)
Pathway
bbub00310
Lysine degradation
bbub01100
Metabolic pathways
bbub04934
Cushing syndrome
bbub05202
Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:
bbub00001
]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
102401126 (KMT2A)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
102401126 (KMT2A)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
102401126 (KMT2A)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03000 Transcription factors [BR:
bbub03000
]
102401126 (KMT2A)
03036 Chromosome and associated proteins [BR:
bbub03036
]
102401126 (KMT2A)
Enzymes [BR:
bbub01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.354 [histone H3]-lysine4 N-trimethyltransferase
102401126 (KMT2A)
Transcription factors [BR:
bbub03000
]
Eukaryotic type
Zinc finger
CXXC CpG-binding proteins
102401126 (KMT2A)
Chromosome and associated proteins [BR:
bbub03036
]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
102401126 (KMT2A)
HMT complexes
MLL-HCF complex
102401126 (KMT2A)
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
SET
FYRC
FYRN
zf-CXXC
PHD
zf-HC5HC2H
zf-HC5HC2H_2
PHD_UBR7-like
PHD_4
PHD_2
Bromodomain
Motif
Other DBs
NCBI-GeneID:
102401126
NCBI-ProteinID:
XP_044785618
LinkDB
All DBs
Position
16:complement(56237073..56315103)
Genome browser
AA seq
3129 aa
AA seq
DB search
MAHSCRWRFPARPGTTGGGGGGGRRGLGGAPRQRVPALLLPPGPPVGGGGPGAPPSPPAV
AAAAAAAGSGGAGVPGGAAAASAASSSSASSSSSSSSSASSGPALLRVGPGFDAALQVSA
AIGTNLRRFRAVFGESGGGGGSGEDEQFLGFGSDEEVRVRSPTRSPSGSMLAQADKLPMT
DKRVASLLKKAKAQLCKIEKSKSLKQTDQPKAQGQESDSSETSVRGPRIKHVCRRAAVAL
GRKRAVFPDDMPTLSALPWEEREKILSSMGNDDKSSIAGSEDAEPLAPPIKPIKPVTRNK
APQEPPVKKGRRSRRCGQCPGCQVPEDCGVCTNCLDKPKFGGRNIKKQCCKMRKCQNLQW
MPSKAYLQKQAKAVKKKEKKSKTSEKKESKESSAVKNSVDSSQKSTPSAREDPAPKKSNG
DPPPRKSVEDKSEEGNTTTPGPEAKHVATPASRKSSKQVSQPAPAIPQQPPSMAPPRKEV
PKTTPSEPKKKPPPPPESGPEQSKQKKVAPRPSIPVKQKPKEKEKPPPVNKQENAGTLNI
LSTLSNGSSSKQKVPADGVHRIRVDFKEDCEAENVWEMGGLGILTSVPITPRVVCFLCAS
SGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQAAKQLLECN
KCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDC
AKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSGTEDEMYEILSNLPES
VAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPET
EETIPSRSSPEGPDPPVLTEVSKQEDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQA
AINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPP
SLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSRE
DSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDG
SLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQR
HRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILND
LSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIA
HSPPSFAEISSKESQNTAEIVSPPSPDRPPHSQTSGSCFYHVISKVPRIRTPTYSPTQRS
PGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTG
STYSRNSVSSVSTTGATADLESSAKAVDHVLGPLNSNANLGQNTPTSSNLQRTAVTVGTK
TSHLDGSSSLETKHSSASDLTSKSSSLKGEKTKMPSSKNAEGSAHNVGYPGIPKLAPQVH
NATAGELNVNKMGTFADLSSVPFSSKEGLPFPPLHLRGQRNERDQQTNGNQSANPNPDEG
AEVKTLKLSGVSSRSSIINEHVGASSRDRRQKGKKSCKETFKEKHSSKPFLEPGQVATGE
EGNLKPEFVDEVLTPDFMGQRSCNNVSSEKIGDKVHPIPGVPKAPSMQVEGSAKELQTPR
KRTVKVTLTPLKMESEGQSKNTLKESSPVSPLQIESVSPTEPVSASESPGDGPVAQPSPN
NTSSQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYG
VRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFSRTVISSGGEER
LTPHNLFREEEQCDLPKISQLDGIDDGTESDTSVTATTRKSSQIPKRNSKENGTENLKMD
RPEDAGEKEHVIKSSVGHKNEPKVDNCHAVSRVKAPGQDSLEAQLSSLESSRRVHTSTPS
DKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLN
LGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTT
RSPTVPSQNSSRLAVISDSGEKRVTITEKASSEGDSSLLSPGVDPSPEGHMTPDHFIQGH
MDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYAPNSTDSPGPSQ
ISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSAPSVMETN
TSVLGPMGSGLTLTTGLNPNLPASQSLFPPAAKGLLPMPHHQHLHSFPAATQSSFPPNIS
SPSGLLIGVQPSPDPQLLVSEASQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSST
PSNIAPSDVVSNMTLINFTPSQLPNHPNLLDLGSLNTSSHRTVPNIIKRSKSGIMYFEQA
PLLPQSVGGTTAPAAGTATISQDTSPLTTGPVSGLASGSSVLNVVSMQTTTAPTSSASVP
GHVALTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPPLGTSQTPSTGA
MTAAPSICVLPSTQTAGVTAASPSGEAEEHYQLHHVNQLLASKTGVLSSQRDLDSAPGSQ
GSSFTQTVDAPNPMGLEQNKALPSAMQASSASPGGSPSSGQRSASPSVPGPTKPKPKIKR
IQLPLDKGSGKKHKVSHLRTSSSEAHIPDQEANTTPQTSVTGTPGAEAEQQDTASVEQSP
QKECGQPAAQVAALPEIQTTQNPAHEQENSEPKTAEEEESNFSSPLMLWLQQEQKRKESI
AEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRML
GILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNF
LASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHG
RGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGN
AARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCG
AKKCRKFLN
NT seq
9390 nt
NT seq
+upstream
nt +downstream
nt
atggcgcacagctgtcggtggcgcttccccgcccgacccgggaccaccgggggcggcggc
ggcggggggcgccggggcctagggggcgccccgcggcaacgcgtcccggccctgctgctt
ccccccgggcctccggtcggcggcggcggccccggggcgcccccctcccccccggctgtg
gcggccgcggcggcggcggcgggaagcggcggggccggggttccagggggagcggccgcc
gcctcagcagcctcctcgtcgtccgcctcgtcttcgtcttcgtcatcgtcctcagcctcc
tccgggccggccctgctccgggtgggcccgggcttcgacgcggcgctgcaggtctcggcc
gccatcggcaccaacctgcgccggttccgggccgtgtttggggagagcggcgggggaggc
ggcagcggagaggatgagcagttcttaggttttggctcagatgaagaagtcagagtacga
agtcccacaaggtctccttcaggctccatgttggctcaggcagacaagcttccaatgact
gacaagagggttgccagcctcctaaaaaaggccaaagcccagctctgcaagattgagaag
agtaagagtcttaaacaaactgaccagcccaaagcacagggtcaagaaagtgactcctcg
gagacctctgtgcgaggaccccggattaaacatgtctgcagaagagctgctgttgccctt
ggccgaaaacgagctgtgtttcctgatgacatgcccaccttgagtgccttaccatgggaa
gaacgagaaaagattttgtcttccatgggaaatgatgacaagtcatcgatcgctggctca
gaagatgctgaacctcttgctccacccatcaaaccaattaagcctgtcaccagaaacaag
gcgcctcaggaacctccggtgaagaagggacggcggtctaggcggtgcgggcagtgtccc
ggctgccaggtgcctgaggactgtggtgtttgcactaactgcttggataagcccaagttt
ggtggccgcaacataaagaagcagtgctgcaagatgcgaaaatgtcagaatctacaatgg
atgccttccaaagcctaccttcagaagcaagcaaaagctgtgaaaaagaaagagaagaaa
tctaagaccagtgaaaagaaggagagcaaagagagcagcgctgtgaagaactcggtagac
tccagtcagaaatctaccccatcggcaagagaggatcctgcccctaagaaaagcaacggt
gaccctcctccccgcaaatccgtggaggacaagagtgaggaagggaacaccaccacccca
ggacctgaggccaagcacgtggccacgcctgcttccaggaagtccagcaagcaggtctcc
cagccggcaccagccatcccccagcaaccccccagcatggcaccaccgagaaaagaagtt
cccaagaccactcccagtgagcccaagaaaaagccacctccgcctccagagtcaggtcca
gagcaaagcaagcagaaaaaagtggctcctcgcccaagtattcctgtaaaacaaaagcca
aaagaaaaggagaaaccacctccagtcaataagcaggaaaatgcaggcactttgaacatc
ctcagcactctctccaatggcagtagctccaagcagaaagttccagcagatggcgtccac
aggatcagagtggactttaaggaggattgtgaagcagaaaatgtgtgggagatgggaggc
ttaggaatcttgacctctgtccctataacacccagggtagtttgctttctctgtgccagt
agtggccacgtggagtttgtgtattgccaagtctgttgtgagcccttccacaagttttgt
ctggaggagaacgagcgccctctggaggaccagctggaaaactggtgttgtcgccgctgc
aagttctgtcatgtctgtgggaggcagcatcaggctgcaaagcagctgctggagtgtaac
aagtgccgaaacagctatcaccctgagtgcctgggaccaaattaccccaccaaacccaca
aagaaaaagaaggtttggatctgtaccaagtgtgttcgctgcaagagctgtggatccacg
actcctggcaaagggtgggatgcacagtggtctcacgatttctcactgtgccatgattgt
gccaaactctttgctaaaggaaacttctgccctctctgtgataagtgttatgatgatgat
gactatgagagtaagatgatgcagtgtgggaaatgtgatcgatgggtccattccaaatgt
gagaatctttcaggtacagaagatgagatgtatgagattctgtctaatctgccggagagt
gtagcctacacgtgtgtgaactgcacagagcggcaccctgcggagtggcgactggccctt
gaaaaagagctccagatctcgctgaagcaagtactgacagccttgttgaactctcggacc
accagccacctgctgcgctaccgacaggctgccaaacctccggacttaaatcctgagaca
gaggagacgataccttctcgtagctccccagaaggacctgatccaccagtgctcactgag
gtcagcaaacaggaagatcaacagcctttagatctggaaggagtcaagaggaaaatggac
caagggaactacacatctgtgttggagttcagcgacgatatcgtgaagatcattcaagca
gccattaattcagatggagggcagccagagattaaaaaagccaacagcatggtcaagtcc
ttctttattcggcaaatggaacgtgtttttccatggttcagtgtcaaaaagtccaggttt
tgggagccaaataaagtatcaagcaacagtgggatgttaccaaacgcagtgcttccacct
tcacttgaccataattatgctcagtggcaggagcgagaggaaaacagccacactgagcag
cctcctttaatgaagaaaatcattccagctcccaaacctaaagggcctggagaaccagac
tcaccaactcctctgcatcctcctacaccaccaattttgagtactgataggagtcgagaa
gacagcccggaactgaacccacccccaggcatagaagacaataggcagtgtgcgctgtgt
ttgacgtacggtgacgacagtgctaatgatgctggccgtttgctttacattggccagaat
gaatggacacatgtaaattgcgctttgtggtcagcagaagtgtttgaagacgatgatgga
tcactaaagaatgtgcatatggctgtgatcaggggcaagcagctgagatgtgaattctgc
caaaagccaggagccactgtgggttgctgccttacatcctgcaccagcaactatcacttc
atgtgttcccgagccaagaactgtgtgtttctggatgataaaaaagtgtattgccaacga
catcgggatttgatcaaaggcgaggtggttcctgagaatggatttgaagtttttagaaga
gtgtttgtggactttgaaggaatcagcttgagaaggaagtttctcaatggattagaacca
gaaaatatccacatgatgattggctccatgacaattgactgcttagggattctgaatgat
ctctctgactgtgaggataagctctttcctattggatatcagtgttctcgggtgtactgg
agcaccacggacgcccgcaagcgctgcgtgtacacgtgcaagatcgtcgagtgccgtcct
ccggtggtggagccagacatcaacagcactgttgaacatgacgaaaacaggaccatcgct
cacagtccaccatcttttgcagaaatttcatccaaggaaagtcaaaacacagcagaaatt
gtaagtcctccatcaccagatcgacctcctcattcccaaacctctggttcctgtttctat
cacgtcatctcaaaggtccctaggattcgaacacccacctattctccaacacagagatct
cctggctgtagaccactgccttctgcaggaagccctaccccaaccactcatgaaatagtc
acagtgggtgaccctttactctcctctggacttcgaagcattggctccaggcgtcacagt
acttcttccttgtcaccccagcggtctaagctccggataatgtctccgatgagaactggg
agcacttactccaggaacagtgtctcctctgtctccaccacaggggccactgcagatctg
gagtcaagtgccaaagcagtggatcatgtcttagggccactgaattctaatgctaattta
gggcagaacactcccacctcttcaaatttgcaaaggacagcggttactgtgggcactaaa
accagtcacttggatggctcttcatctttagaaacgaagcattccagtgcttcagacttg
acatccaagagctcctctttgaagggagagaagaccaaaatgccgagttccaagaacgca
gagggatcggcccataatgttggttaccctggcattccgaaactggctccgcaggttcat
aatgcaacagctggagaattaaatgttaataaaatgggcacttttgctgacctttcttca
gtgccattttcttctaaagagggcctccccttcccaccactccatttgagagggcagaga
aacgagcgagaccaacagacaaatggcaaccagtcagcaaaccccaatcccgatgaaggt
gctgaagtcaaaaccttgaagctgtctggagtgagcagcagatcatccattatcaatgaa
catgtgggagccagctccagagataggagacagaaaggcaaaaaatcttgtaaagaaact
ttcaaagaaaagcattccagtaaacctttcttggaacctggtcaggtggcaactggtgag
gaaggaaacctaaagccagagtttgttgatgaagtgttgactcctgatttcatggggcaa
cgatcatgtaataatgtttcttctgagaagattggggacaaagtccatcctattccagga
gtccccaaagctccatccatgcaagtggaagggtctgcaaaggaattacagacaccccgg
aaacgcacagttaaagtaacactgacacctctaaaaatggagagtgagggtcagtccaag
aacaccctgaaagaaagtagtcccgtttcccctttgcagatagagtctgtgtctccaaca
gaaccagtttctgcctcagaaagcccaggagatggtcctgtggcccaaccaagccccaat
aatacctcatcccaggattctcaaagtaacaactatcagaatcttccagtacaggacaga
aacctgatgcttccggatggccccaaacctcaggaagatggctctttcaagaggagatac
ccccgccgcagtgcccgggcgcgctctaacatgttctttgggctcaccccactctatgga
gtaagatcctatggcgaagaagacattccattttacagcagctcaactgggaagaagcga
ggcaagaggtctgctgaaggacaggtggacggggcggatgacctgagcacttcagatgaa
gacgacttatactattacaacttctctaggacagtgatttcttcaggtggagaggaacgg
ctgacaccccataatttatttcgggaggaagaacaatgtgatcttccaaaaatctcacag
ttggatggcatcgatgatgggacagagagtgataccagcgtcacagccacaactcggaag
agcagccagattccaaaaagaaacagtaaagaaaacggaacagagaacttgaagatggat
cggcctgaagacgctggggaaaaggaacatgtcattaagagctcagttggccacaagaat
gagccaaaggtggataactgccacgccgtgagcagagtgaaagcaccgggccaggactcc
ctggaggctcagctcagctcgctggagtcgagccgcagggtccacacaagcaccccttca
gataaaaacttgctggacacctataacaccgagctcctgaagtcagattcggataacaac
aacagtgacgactgtgggaacatcctgccctcggacattatggactttgtcctaaagaat
actccgtccatgcaggctttgggtgagagcccagagtcctcttcgtcagaactcctcaac
cttggtgaaggcttgggtcttgacagcaatcgtgaaaaagacatgggtctttttgaagtg
ttttcccagcagttgccgacgacggagcctgtggacagtagtgtctcttcctccatctca
gcggaggagcagtttgagttgcccttagagctgccatcagatctctccgtcctgaccacc
cggagtcccacggtgcctagccagaactccagtaggctagccgtgatctcagactcagga
gagaagagagtaaccatcacagaaaaagcctcctctgaaggcgactcctccctgctgagt
ccaggagtagaccccagtcccgagggccacatgactcccgaccactttatccagggtcac
atggatgcggaccacatctccagccctccctgtggctctgtggagcaaggtcatggcaac
aatcaggacttaactagaaacagcagcacccctggccttcaggtacccgtttcccctact
gttcccatccagaatcagaaatacgcgcccaactccactgacagccctggcccgtctcag
atttccaatgccgctgtccagaccactccgccccacctgaagccagccactgagaaactc
attgttgttaaccagaacatgcagccactctacgtcctccaaacccttccgaatggagtg
acccagaaaatccagctgacctcgtctgtaagttcagcacccagtgtgatggagacaaac
acgtccgtgttgggccccatgggaagtggtctcaccctcaccacaggactcaacccgaac
ctgccagcctctcagtcgttgttccctcctgctgccaaaggcttgctccccatgcctcat
caccagcacttacattccttccccgccgctactcagagtagcttcccccccaacatcagc
agtccttcgggcctactcatcggggttcagccttctccagacccccagcttttggtttca
gaagccagccagaggacagacctcagtaccacggtagccactccatcctctggactcaag
aaaagacccatatctcgcctgcagacccgaaagaataagaaacttgccccctctagtacc
ccttccaacattgccccttcagacgtggtttccaacatgacactgattaacttcactccc
tcccaacttccgaatcatcccaatctcttagacttggggtcactgaatacttcatctcac
cgaactgtccccaacatcataaaaaggtctaaatctggcattatgtattttgaacaggca
cccctgctgccgcagagtgtgggggggaccactgccccggcggcaggcactgccaccata
agccaggataccagccccctcacgacagggcccgtgtctggcctggcctccggttcctcc
gtcctgaacgttgtatccatgcaaactaccaccgcccccacaagtagtgcatctgttcca
ggacacgtcgcattaaccaaccccaggttgctgggtaccccggatatcggctccataagc
aatcttctaatcaaagccagccagcagagcctggggattcaagaccagcctgtggcttta
ccgccaagttcaggaatgtttccaccactggggacgtcacagactccctccacgggcgcg
atgaccgctgcacccagcatctgtgtgctcccctctacccagacagcgggtgtcacagct
gcttcgccttctggggaagcagaagaacactatcagctccaccatgtgaaccagctcctc
gccagcaaaactggggttctctcttcccaacgggatcttgattctgctccagggtcccag
ggatccagctttacccagacagtagatgctcctaatcccatgggcctggagcagaacaag
gctttaccctcagctatgcaagccagctcggcctctccagggggttccccatcctccgga
cagcggtcagcaagtccctcagtgccgggacccacgaaacccaaaccaaaaatcaaacgg
attcagctgcctttggacaaagggagtggcaagaagcacaaagtttcccacttgcggacc
agttcttctgaagcacacattccagaccaagaagccaacacgacaccccagacctcagtc
acagggactccaggagcagaggctgagcagcaggatacagctagtgtggaacagtcacca
cagaaggagtgtgggcagcctgcagcgcaagtggctgctcttcctgagattcagacaaca
cagaatccagcacatgaacaagaaaattcagaacctaaaacagcagaagaagaagaaagt
aatttcagctctccactgatgctctggctccagcaagaacagaagcggaaggagagcatt
gctgagaaaaagcccaagaaaggacttgtctttgaaatttcaagtgatgatggctttcag
atatgtgcagaaagtattgaagatgcctggaagtcgctgacagacaaagtccaggaggct
cggtccaacgcccgcctgaagcagctctcatttgcaggtgtgaacggtttgcggatgctg
gggattctccatgacgctgttgtattcctgattgagcaactgtctggtgccaagcactgt
aggaattacaaattccgtttccacaaaccagaggaggccaatgagcccccactgaaccct
cacggctcagccagggctgaagtccacctgaggaagtcagcctttgacatgtttaacttc
ctggcttctaaacaccggcagcctcctgagtacaaccccaatgacgaggaagaggaggag
gtgcagctgaagtcagctcggagggcaactagtatggatctaccaatgcccatgcgtttc
cggcacttaaaaaagacttctaaggaggcggttggtgtctacaggtctcccatccacggc
cggggtcttttttgtaagagaaacattgatgcaggtgagatggtgattgagtatgctggc
aacgtcatccgttccatccagactgacaagcgagagaagtactatgacagcaagggcatc
ggctgctacatgttccggatcgatgactccgaggtggtggacgccaccatgcacgggaac
gccgcccgcttcatcaaccactcatgtgagcccaactgctactctcgggtcatcaacatc
gatgggcagaagcacattgtcatcttcgccatgcgcaagatctaccgaggggaggaactc
acttacgactataaattccccattgaggacgccagcaacaagctcccctgcaactgcggt
gccaagaaatgccggaagttcctaaactaa
DBGET
integrated database retrieval system
