Bubalus bubalis (water buffalo): 102402341
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Entry
102402341 CDS
T05912
Symbol
FPGS
Name
(RefSeq) folylpolyglutamate synthase, mitochondrial isoform X4
KO
K01930
folylpolyglutamate synthase [EC:
6.3.2.17
]
Organism
bbub
Bubalus bubalis (water buffalo)
Pathway
bbub00790
Folate biosynthesis
bbub01100
Metabolic pathways
bbub01240
Biosynthesis of cofactors
bbub01523
Antifolate resistance
bbub04981
Folate transport and metabolism
Brite
KEGG Orthology (KO) [BR:
bbub00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
102402341 (FPGS)
09150 Organismal Systems
09154 Digestive system
04981 Folate transport and metabolism
102402341 (FPGS)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
102402341 (FPGS)
Enzymes [BR:
bbub01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.17 tetrahydrofolate synthase
102402341 (FPGS)
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GFIT
Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Motif
Other DBs
NCBI-GeneID:
102402341
NCBI-ProteinID:
XP_006074542
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Position
12:97921101..97946404
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AA seq
549 aa
AA seq
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MKAEAYQDAVRTLNTLQTNANYLEMVKRKRGDPQTQLEAMKLYLARSGLQVEDLDQLNII
HITGTKGKGSTCAFTERILRSYGLKTGFFSSPHLVQVRERIRINGQPISSELFTKHFWRL
YHRLEETKDDSSCVSMPGYFRFLTLMAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPVV
CGITSLGIDHTGLLGDTMEKIAWQKGGIFKSGVPAFTVLQPDEPLAVLRDRAQQISCPLY
LCPPLQALEEGGPPLTLGLEGEHQRSNAALALQVARCWLQQKGYQDAGELKASRPSLPGQ
LSLAPVFQPTPLMQQGLRHTEWPGRTQLLRRGPLTWYLDGAHTTSSMQACVRWFRQALHR
CERPDSGSEVRVLLFNSTGDRDSAALLKLLQPCQFDYAIFCPNLADMASTDNADQQNFTV
TLDQVLLRCLAHQQHWSRLHEQQVSPDPWSTPGQEQDGPASLLLASHPPHTHSASSLVFS
CISHALQWITQGRDPLFQPPSPPRGLLAHPVADSGAMVLQEAAAVHVLVTGSLHLVGGVL
KLLEPSLSQ
NT seq
1650 nt
NT seq
+upstream
nt +downstream
nt
atgaaagcagaagcctatcaggatgccgtgcgcacactcaacaccctgcagaccaatgct
aactacttggagatggtgaagcgtaagcggggtgacccccagacacagctggaagccatg
aagctgtacttggcacgaagtgggctgcaggtggaggacttggaccaactgaacattatc
cacatcactggaaccaaggggaagggctccacgtgtgccttcactgaacgtatcctccga
agctatggcctgaagacggggttctttagctctccccacctggtgcaggtgcgtgagcgg
atccgcatcaatgggcagcccataagctccgagctcttcaccaagcacttctggcgcctc
taccaccggctggaggagaccaaggacgacagcagctgtgtctccatgcccggctacttc
cgcttcctcaccctcatggccttccacgtcttcctccaagagaaggtagacctggccgtg
gtggaagtaggcattggcggggcttacgactgcaccaacatcatcaggaagcctgtggtg
tgtgggatcacctctcttggcatcgaccacactggccttctgggggacacgatggagaag
atcgcatggcagaaagggggcatttttaagagtggcgtccctgccttcaccgtgctccag
cctgacgagccgctggcggtgctaagggacagggctcagcagatctcatgtcccctctac
ctgtgcccaccactacaagccctggaggaaggggggccaccactgaccctgggcctggag
ggagagcaccagcggtccaatgctgccctggccttgcaggtggcccgctgctggctgcag
cagaaaggttaccaggatgctggggagctgaaggcatccaggcccagcctcccggggcag
ctgtccctggcacctgtgtttcagcccacgcccctcatgcagcaggggcttcggcacacg
gaatggccaggtcggacgcagttgctgcggcgcgggccccttacctggtacctggacggc
gcgcacaccaccagcagcatgcaagcctgtgtgcgctggttccgccaggcgctgcaccgc
tgcgagaggccggacagcgggtccgaggtgcgcgtcttgctcttcaactccactggggac
cgggattccgcggccctgctgaagctgctgcagccctgccagtttgactatgccattttc
tgccctaacctggcagatatggcatcaacagacaatgcagaccaacagaacttcacagtg
acactggaccaggtgctgctccgctgcctcgcccaccaacagcactggagtcgcctgcat
gagcagcaggtcagcccggacccctggagcacccccggccaggagcaggatgggcccgca
tctctgctgctggcgtctcacccaccccacacccacagtgccagctccctcgtcttcagc
tgcatctcccacgccttgcagtggatcacccaaggccgggaccctctctttcagccgccc
agtcccccacggggcctcctcgcccaccctgtggcagacagcggggccatggtactccaa
gaggctgccgccgtccatgtgctggtcacaggcagcctgcacctggtgggcggtgtcctg
aagctgctggagccctccctgtcccaatag
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