Bubalus bubalis (water buffalo): 102408451
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Entry
102408451 CDS
T05912
Symbol
NOS3
Name
(RefSeq) nitric oxide synthase, endothelial
KO
K13242
nitric-oxide synthase, endothelial [EC:
1.14.13.39
]
Organism
bbub
Bubalus bubalis (water buffalo)
Pathway
bbub00220
Arginine biosynthesis
bbub00330
Arginine and proline metabolism
bbub01100
Metabolic pathways
bbub04020
Calcium signaling pathway
bbub04022
cGMP-PKG signaling pathway
bbub04066
HIF-1 signaling pathway
bbub04071
Sphingolipid signaling pathway
bbub04151
PI3K-Akt signaling pathway
bbub04370
VEGF signaling pathway
bbub04371
Apelin signaling pathway
bbub04611
Platelet activation
bbub04915
Estrogen signaling pathway
bbub04921
Oxytocin signaling pathway
bbub04926
Relaxin signaling pathway
bbub04931
Insulin resistance
bbub04933
AGE-RAGE signaling pathway in diabetic complications
bbub05415
Diabetic cardiomyopathy
bbub05417
Lipid and atherosclerosis
bbub05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
bbub00001
]
09100 Metabolism
09105 Amino acid metabolism
00220 Arginine biosynthesis
102408451 (NOS3)
00330 Arginine and proline metabolism
102408451 (NOS3)
09130 Environmental Information Processing
09132 Signal transduction
04370 VEGF signaling pathway
102408451 (NOS3)
04371 Apelin signaling pathway
102408451 (NOS3)
04066 HIF-1 signaling pathway
102408451 (NOS3)
04020 Calcium signaling pathway
102408451 (NOS3)
04071 Sphingolipid signaling pathway
102408451 (NOS3)
04022 cGMP-PKG signaling pathway
102408451 (NOS3)
04151 PI3K-Akt signaling pathway
102408451 (NOS3)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
102408451 (NOS3)
09152 Endocrine system
04915 Estrogen signaling pathway
102408451 (NOS3)
04921 Oxytocin signaling pathway
102408451 (NOS3)
04926 Relaxin signaling pathway
102408451 (NOS3)
09160 Human Diseases
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
102408451 (NOS3)
05418 Fluid shear stress and atherosclerosis
102408451 (NOS3)
05415 Diabetic cardiomyopathy
102408451 (NOS3)
09167 Endocrine and metabolic disease
04931 Insulin resistance
102408451 (NOS3)
04933 AGE-RAGE signaling pathway in diabetic complications
102408451 (NOS3)
Enzymes [BR:
bbub01000
]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
1.14.13.39 nitric-oxide synthase (NADPH)
102408451 (NOS3)
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Gene cluster
GFIT
Motif
Pfam:
NO_synthase
FAD_binding_1
Flavodoxin_1
NAD_binding_1
Motif
Other DBs
NCBI-GeneID:
102408451
NCBI-ProteinID:
XP_006043118
EnsemblRapid:
ENSBBUG00015010833
LinkDB
All DBs
Position
8:113073489..113092641
Genome browser
AA seq
1205 aa
AA seq
DB search
MGNLKSVGQEPGPPCGLGLGLGLGLCGKQGPASPAPEPSRAPAPATPHAPDHSPAPNSPT
LTRPPEGPKFPRVKNWELGSITYDTLCAQSQQDGPCTPRRCLGSLVLPRKLQTRPSPGPP
PAEQLLSQARDFINQYYSSIKRSGSQAHEERLQEVEAEVASTGTYHLRESELVFGAKQAW
RNAPRCVGRIQWGKLQVFDARDCSSAQEMFTYICNHIKYATNRGNLRSAITVFPQRAPGR
GDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDE
APELFVLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFSAAPFSGWYM
STEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINLAVLHSFQLAKVTIV
DHHAATVSFMKHLDNEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYILSPAFRYQPD
PWKGSATKGAGITRKKTFKEVANAVKISASLMGTLMAKRVKATILYASETGRAQSYAQQL
GRLFRKAFDPRVLCMDEYDVVSLEHEALVLVVTSTFGNGDPPENGESFAAALMEMSGPYN
SSPRPEQHKSYKIRFNSVSCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYP
HFCAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAKAAFQASCETFCVGEEAKA
AAQDIFSPKRSWKRQRYRLSAQAEGLQLLPGLIHVHRRKMFQATVLSVENLQSSKSTRAT
ILVRLDTAGQEGLQYQPGDHIGICPPNRPGLVEALLSRVEDPPPPTESVAVEQLEKGSPG
GPPPSWVRDPRLPPCTLRQALTFFLDITSPPSPRLLRLLSTLAEEPSEQQELETLSQDPR
RYEEWKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPNAHPGEVHLTVA
VLAYRTQDGLGPLHYGVCSTWLSQLKTGDPVPCFIRGAPSFRLPPDPYVPCILVGPGTGI
APFRGFWQERLHDIESKGLQPAPMTLVFGCRCSQLDHLYRDEVQDAQERGVFGRVLTAFS
REPDSPKTYVQDILRTELAAEVHRVLCLERGHMFVCGDVTMATSVLQTVQRILATEGDME
LDEAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERHLRGAVPWAFDPPGP
DTPGP
NT seq
3618 nt
NT seq
+upstream
nt +downstream
nt
atgggcaacttgaagagtgtgggccaggagcccgggcccccctgcggcctggggctgggg
ctgggcctcgggctatgcggcaagcagggcccagcctccccggcacctgagcccagccgg
gcccccgcacccgccaccccgcacgcaccagaccacagcccagctcccaacagccccacg
ctgacccggcctccggaggggcccaagttccctcgagtgaagaactgggagctggggagc
atcacctacgacactctgtgcgcgcagtcccaacaggacgggccctgcactcccagacgc
tgcctgggctccctggtgttgccccggaaactgcagacccggccctccccgggacctcca
cccgctgagcagctgctgagccaggccagggacttcatcaaccagtactacagctccatc
aagaggagcggctcccaggctcacgaagagcggcttcaggaggtggaggccgaggtggca
tccacgggcacctaccacctccgagagagcgagctggtgttcggggccaagcaggcctgg
cgcaacgcaccccgctgcgtgggccgcatccagtgggggaagctgcaggtgttcgatgcc
cgggactgcagctcagcacaggagatgttcacctacatctgcaaccacatcaagtacgcc
accaaccgcggcaaccttcgctcggccatcacagtgttcccacagcgcgccccgggccgt
ggagacttccggatctggaacagccagctggtgcgctacgcgggctacagacagcaggat
ggctctgtgcgtggggacccagccaacgtggagatcacagagctctgcatccagcacggc
tggacccccggaaacggccgcttcgacgtgctgcccctgctgctccaggccccagacgag
gctccagagctctttgttctgccccccgagctggtccttgaagtgcccctggagcacccc
acactggagtggttcgcagccctgggcctgcgctggtatgccctcccggccgtgtccaac
atgctgctggaaatcgggggtctggagttctctgcggcccccttcagcggctggtacatg
agcacggagattggcacacggaacttgtgtgaccctcaccgctacaatatcctggaggat
gtggccgtctgcatggacctcgacacgcggaccacctcgtccctgtggaaggacaaggcg
gccgtggagatcaacctggctgtgctgcacagctttcagctcgccaaggtgaccatcgtg
gaccaccacgccgccacagtgtccttcatgaagcacctggacaacgagcagaaggccagg
gggggctgccccgccgactgggcctggatcgtgccccccatctcgggcagcctcacgccc
gtcttccaccaggagatggtcaactacatcctgtcccctgccttccgctaccagccagac
ccctggaaggggagcgcaaccaagggtgccggcatcaccagaaagaagacctttaaggaa
gtggccaacgcggtgaagatctctgcctcactcatgggcaccctgatggccaagcgagtg
aaagcaaccatcctgtacgcctctgagaccggccgggcccagagttatgctcagcagctg
gggaggctcttccggaaggccttcgatccccgggtcctgtgcatggatgagtatgacgtg
gtgtccctggagcacgaggcgctggtgctggtggtgaccagcacctttgggaatggcgat
cccccggagaatggagagagttttgcagctgccctgatggagatgtcggggccctacaac
agctccccgcggccagaacagcacaagagttacaagatccgcttcaacagcgtctcctgc
tcagacccactggtgtcctcctggcggcggaagagaaaggagtccagcaacacagatagc
gcaggggccctggggaccctcaggttctgtgtgttcggactgggctcccgggcgtacccc
cacttctgcgccttcgcgcgagcggtggacacccggctggaagagctgggaggggagcgg
ctgctgcagctgggccagggcgacgagctctgcggccaggaggaggccttccgtggctgg
gcaaaggcggccttccaggcctcctgcgagacattctgtgttggggaggaggccaaggct
gccgcccaggacatcttcagccccaaaaggagctggaaacgccagaggtaccggctgagc
gcccaggccgagggcctccagctgctgccaggcctgatccacgtgcacagacggaagatg
tttcaggccacagtcctctcggtggaaaacctgcaaagcagcaagtccacccgggccacc
atcctcgtgcgcctggacactgcaggccaggaggggctgcagtaccagccgggggaccac
ataggcatctgcccgcccaaccggccgggcctggtggaggcgctgctgagccgcgtggag
gacccgccaccgcccaccgagtctgtggctgtggagcagctggagaaaggcagcccaggc
ggccctcctcccagctgggtgcgggacccacggctgcccccgtgcacactgcgccaggct
ctcaccttcttcctggacatcacctccccgcccagcccccggcttctccgactgctcagc
accctggccgaagaacccagcgagcagcaggagctcgagaccctcagtcaggacccccgg
cgctatgaggagtggaagtggttccgctgccccacgctgctggaggtgctggagcagttc
ccgtccgtggcgctgcctgccccgctgctcctcacccagctgcccctgctgcagccccgg
tactattccgtcagctcggcccccaatgcccaccccggagaggtccacctcacagtggcc
gtgctggcgtacaggacccaagatgggctgggccccctacactacggggtctgctccaca
tggctgagccagctcaagactggagaccccgtgccctgcttcatcaggggggctccctcc
ttccggctgccgcctgacccctacgtgccctgcatcctcgtgggccctggcactggcatc
gcccccttccggggattttggcaggagaggctacatgacattgagagcaaagggctgcag
cccgcccccatgaccctggtgttcggctgccggtgctcccaactcgaccatctctaccgc
gacgaggtgcaggacgcccaggagcgcggggtgtttggccgcgtcctcaccgccttctcc
cgggaacctgacagccccaagacttacgtacaggacatcctgagaaccgagctggctgcc
gaggtgcaccgcgtgctgtgcctcgagcggggccacatgtttgtctgcggcgacgtcact
atggcaaccagcgtcctgcagacggtgcagcgcatcttggcgacagagggcgacatggag
ctggacgaggcgggcgacgtcatcggcgtgctgcgggatcagcaacgctatcacgaggac
attttcggcctcacgctgcgcacccaggaggtgacaagccgtatacgtacccagagcttt
tccctgcaggaacggcatctgcggggcgcggtgccctgggccttcgacccgcccggccca
gacacccccggcccctga
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