KEGG   Bubalus bubalis (water buffalo): 102412320
Entry
102412320         CDS       T05912                                 
Symbol
PLCB4
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
bbub  Bubalus bubalis (water buffalo)
Pathway
bbub00562  Inositol phosphate metabolism
bbub01100  Metabolic pathways
bbub04015  Rap1 signaling pathway
bbub04020  Calcium signaling pathway
bbub04022  cGMP-PKG signaling pathway
bbub04062  Chemokine signaling pathway
bbub04070  Phosphatidylinositol signaling system
bbub04071  Sphingolipid signaling pathway
bbub04072  Phospholipase D signaling pathway
bbub04081  Hormone signaling
bbub04082  Neuroactive ligand signaling
bbub04261  Adrenergic signaling in cardiomyocytes
bbub04270  Vascular smooth muscle contraction
bbub04310  Wnt signaling pathway
bbub04371  Apelin signaling pathway
bbub04540  Gap junction
bbub04611  Platelet activation
bbub04613  Neutrophil extracellular trap formation
bbub04621  NOD-like receptor signaling pathway
bbub04713  Circadian entrainment
bbub04720  Long-term potentiation
bbub04723  Retrograde endocannabinoid signaling
bbub04724  Glutamatergic synapse
bbub04725  Cholinergic synapse
bbub04726  Serotonergic synapse
bbub04728  Dopaminergic synapse
bbub04730  Long-term depression
bbub04742  Taste transduction
bbub04750  Inflammatory mediator regulation of TRP channels
bbub04911  Insulin secretion
bbub04912  GnRH signaling pathway
bbub04915  Estrogen signaling pathway
bbub04916  Melanogenesis
bbub04918  Thyroid hormone synthesis
bbub04919  Thyroid hormone signaling pathway
bbub04921  Oxytocin signaling pathway
bbub04922  Glucagon signaling pathway
bbub04924  Renin secretion
bbub04925  Aldosterone synthesis and secretion
bbub04926  Relaxin signaling pathway
bbub04927  Cortisol synthesis and secretion
bbub04928  Parathyroid hormone synthesis, secretion and action
bbub04929  GnRH secretion
bbub04933  AGE-RAGE signaling pathway in diabetic complications
bbub04934  Cushing syndrome
bbub04935  Growth hormone synthesis, secretion and action
bbub04961  Endocrine and other factor-regulated calcium reabsorption
bbub04970  Salivary secretion
bbub04971  Gastric acid secretion
bbub04972  Pancreatic secretion
bbub04973  Carbohydrate digestion and absorption
bbub05010  Alzheimer disease
bbub05016  Huntington disease
bbub05017  Spinocerebellar ataxia
bbub05022  Pathways of neurodegeneration - multiple diseases
bbub05142  Chagas disease
bbub05143  African trypanosomiasis
bbub05146  Amoebiasis
bbub05163  Human cytomegalovirus infection
bbub05200  Pathways in cancer
bbub05415  Diabetic cardiomyopathy
bbub05417  Lipid and atherosclerosis
Module
bbub_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:bbub00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    102412320 (PLCB4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    102412320 (PLCB4)
   04310 Wnt signaling pathway
    102412320 (PLCB4)
   04371 Apelin signaling pathway
    102412320 (PLCB4)
   04020 Calcium signaling pathway
    102412320 (PLCB4)
   04070 Phosphatidylinositol signaling system
    102412320 (PLCB4)
   04072 Phospholipase D signaling pathway
    102412320 (PLCB4)
   04071 Sphingolipid signaling pathway
    102412320 (PLCB4)
   04022 cGMP-PKG signaling pathway
    102412320 (PLCB4)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    102412320 (PLCB4)
   04081 Hormone signaling
    102412320 (PLCB4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    102412320 (PLCB4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    102412320 (PLCB4)
   04613 Neutrophil extracellular trap formation
    102412320 (PLCB4)
   04621 NOD-like receptor signaling pathway
    102412320 (PLCB4)
   04062 Chemokine signaling pathway
    102412320 (PLCB4)
  09152 Endocrine system
   04911 Insulin secretion
    102412320 (PLCB4)
   04922 Glucagon signaling pathway
    102412320 (PLCB4)
   04929 GnRH secretion
    102412320 (PLCB4)
   04912 GnRH signaling pathway
    102412320 (PLCB4)
   04915 Estrogen signaling pathway
    102412320 (PLCB4)
   04921 Oxytocin signaling pathway
    102412320 (PLCB4)
   04926 Relaxin signaling pathway
    102412320 (PLCB4)
   04935 Growth hormone synthesis, secretion and action
    102412320 (PLCB4)
   04918 Thyroid hormone synthesis
    102412320 (PLCB4)
   04919 Thyroid hormone signaling pathway
    102412320 (PLCB4)
   04928 Parathyroid hormone synthesis, secretion and action
    102412320 (PLCB4)
   04916 Melanogenesis
    102412320 (PLCB4)
   04924 Renin secretion
    102412320 (PLCB4)
   04925 Aldosterone synthesis and secretion
    102412320 (PLCB4)
   04927 Cortisol synthesis and secretion
    102412320 (PLCB4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    102412320 (PLCB4)
   04270 Vascular smooth muscle contraction
    102412320 (PLCB4)
  09154 Digestive system
   04970 Salivary secretion
    102412320 (PLCB4)
   04971 Gastric acid secretion
    102412320 (PLCB4)
   04972 Pancreatic secretion
    102412320 (PLCB4)
   04973 Carbohydrate digestion and absorption
    102412320 (PLCB4)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    102412320 (PLCB4)
  09156 Nervous system
   04724 Glutamatergic synapse
    102412320 (PLCB4)
   04725 Cholinergic synapse
    102412320 (PLCB4)
   04728 Dopaminergic synapse
    102412320 (PLCB4)
   04726 Serotonergic synapse
    102412320 (PLCB4)
   04720 Long-term potentiation
    102412320 (PLCB4)
   04730 Long-term depression
    102412320 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    102412320 (PLCB4)
  09157 Sensory system
   04742 Taste transduction
    102412320 (PLCB4)
   04750 Inflammatory mediator regulation of TRP channels
    102412320 (PLCB4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    102412320 (PLCB4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102412320 (PLCB4)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    102412320 (PLCB4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    102412320 (PLCB4)
   05142 Chagas disease
    102412320 (PLCB4)
   05143 African trypanosomiasis
    102412320 (PLCB4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102412320 (PLCB4)
   05016 Huntington disease
    102412320 (PLCB4)
   05017 Spinocerebellar ataxia
    102412320 (PLCB4)
   05022 Pathways of neurodegeneration - multiple diseases
    102412320 (PLCB4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    102412320 (PLCB4)
   05415 Diabetic cardiomyopathy
    102412320 (PLCB4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    102412320 (PLCB4)
   04934 Cushing syndrome
    102412320 (PLCB4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:bbub04131]
    102412320 (PLCB4)
Enzymes [BR:bbub01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     102412320 (PLCB4)
Membrane trafficking [BR:bbub04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    102412320 (PLCB4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    102412320 (PLCB4)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 PLC-beta_C EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 102412320
NCBI-ProteinID: XP_044784244
LinkDB
Position
14:complement(81237050..81717591)
AA seq 1200 aa
MVLTLIMAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEG
KEGQVLECSLINSVRLGATPKDPKILAALEALGKSENDLEGRIVCVCSGADLVNISFTYM
VAENPEITKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFA
SGKTEKVIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKT
DYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPVEDLKKQGLISSDGFCR
YLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGC
RCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSK
YQQYKMSKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQL
EALKSMMEAGESAAPVNILEDDNEEEIESAEQEEEAHPEYKYGNELSADDLGHKEAIANS
VKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSS
FNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTP
DLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLS
DKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAV
YDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDA
LSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQSSSELR
PTTTAALGAGLEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELTSLKKKHAKEHSTMQ
KLHCTQVDKIVAQYDKEKLTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSDHKSKVK
EIVAQHTKEWSDMINTHSAEEQEIRDLHLSQQCELLRKLLISAHEQQTQQLKLSHDRESK
EMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSKEMD
QLKKVQLEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEIGSRDGPQTSNSCVKLQDAN
NT seq 3603 nt   +upstreamnt  +downstreamnt
atggtcttgactctaatcatggccaaaccttatgaatttaattggcagaaggaagttcct
tcctttttgcaagaaggagcagtttttgacagatatgaagaggaatcctttgtgtttgaa
cccaactgcctcttcaaagtagatgaatttggcttctttctgacctggagaagtgaaggc
aaggaaggccaagtgctagaatgctccctcatcaacagtgttcggctgggagccacaccg
aaggatcccaaaattttggctgctcttgaagctcttggcaaatcagaaaatgatctggaa
gggcggatagtttgcgtctgcagtggtgcagatctggtgaacatcagtttcacgtacatg
gtggctgaaaatccagaaataactaagcaatgggtcgaaggcctgagatccatcattcac
aacttcagggccaacaacgtcagcccgatgacgtgcctcaagaagcactggatgaaattg
gcatttatgaccaacacaaatgggaaaattccagttaggagtattactagaacctttgca
tcggggaaaacagaaaaggtgatctttcaagcactcaaggagctaggtcttcccagtgga
aagaacgatgaaattgagcccgccgcatttacttatgaaaagttctatgaactgacacaa
aagatttgtcctcggacagatatagaggatcttttcaaaaaaatcaatggagacaaaact
gattatttaacggtagaccaattagtgagctttctaaatgaacatcaacgagatcctcga
ctgaatgaaattttattcccattttatgatgctaaaagggcaatgcagatcattgagatg
tatgagcctgttgaagatttgaagaaacaaggcctcatatcaagtgatgggttttgcaga
tacctgatgtcagatgaaaatgcccccgtcttcctagatcgtctagagctgtaccaagaa
atggaccaccctctggctcactacttcatcagctcttcccacaacacctatctcactggc
agacagtttggtgggaaatcgtcagtagaaatgtacagacaggtcctcctggctggttgc
aggtgtgttgaacttgactgttgggatggaaaaggtgaggaccaggagccgataataact
catgggaaagcaatgtgcacagatatccttttcaaggatgttattcaagccatcaaggaa
actgcctttgtcacatcggaatatcctgtaattctctcctttgaaaatcactgcagcaaa
tatcaacagtacaagatgtccaaatactgtgaagatctatttggagatctcctgttgaaa
caagcacttgaatcacatccactggaaccaggcagacccttgccgtccccgaatgacctc
aaaagaaaaatactcatcaaaaacaaacgactgaaacctgaggttgaaaaaaaacagctt
gaagctttgaaaagcatgatggaagcaggagaatccgctgccccagtaaacatcttagag
gatgacaatgaagaggaaatagaaagtgcggagcaagaggaggaagcccaccctgaatac
aaatatggaaatgaactttctgcagatgacttgggtcacaaggaagctattgccaatagt
gtcaagaagggcctggttaccgtagaagatgagcaggcgtggatggcatcttataaatat
gtgggtgctaccactaatatccatccgtatttgtccacaatgatcaactacgcgcagcct
gtaaagtttcaaggtttccatgtggctgaagaacgcaatattcattataacatgtcctct
tttaatgagtcagtcggtctaggctacttgaagacacacgccattgaatttgtgaattat
aataaacggcaaatgagccgcatttaccccaagggaggccgagtggactccagtaattat
atgcctcagattttctggaacgctggctgccagatggtttcgctgaactatcaaacccca
gatttagcgatgcagttgaatcaggggaaatttgagtataatggatcgtgcgggtacctt
ctcaaaccagatttcatgagacggcctgatcgaacatttgatcctttctctgaaacgcct
gttgatggggttattgcagccacttgctccgtgcaggtcatatcaggtcagttcttatca
gataagaaaatcggcacatatgtagaagtggatatgtatgggctgcccacggacactatc
cggaaggagttccgcactcgcatggtgatgaacaatggactcaatccagtttacaatgaa
gaatcatttgtgtttcggaaggtgatcctccccgacctggctgtcttgaggatcgccgtg
tatgatgacaacaacaagctgatcggccagaggattctgcccctggacggcctccaagca
ggctatcgacacatatccctccggaatgagggaaataaacctttatcgctgccaaccatt
ttctgcaatattgtcctaaaaacatatgtgcctgatggattcggagatattgtggatgct
ttatcagatccaaagaaatttctttccattacggaaaagagagcggatcaaatgagagct
atgggcattgaaactagtgacatcgccgatgtgcccagtgacacttcgaagaatgacaag
aaagggaaagccaacacagccaaagcgaatgtgacccctcagagcagctcggagctcagg
ccaaccaccacagctgccctgggggctggcctggaggccaagaaaggtattgaactgatc
cctcaagtgaggatagaagatttaaagcagatgaaggcttacttgaagcatttaaagaaa
caacagaaagagctgacttctttaaaaaagaaacatgcaaaggagcacagtaccatgcag
aaactccattgcactcaagttgacaagattgtggcacagtacgacaaggagaaattgact
cacgagaaaatcctagagaaggcaatgaagaagaaagggggaagtaattgtcttgaaatg
aagaaagaaacagaaattaaaattcagacactgacatcagatcacaaatctaaggtcaag
gagattgtggcacagcacacaaaggagtggtcagacatgatcaacacccacagtgcggag
gagcaggagatccgggacctgcacctcagccagcagtgcgagctgctcagaaagctcctg
atcagcgcccacgagcagcagacccagcagctgaaactgtcccatgacagggaaagcaaa
gagatgcgagcacaccaagctaagatttctatggaaaatagcaaagccattagccaagat
aaatccatcaagaataaagcagaacgggaaaggagagtcagggagttaaatagcagcaac
actaaaaagtttctggaagaaagaaagcgactcgccatgaagcagtccaaagaaatggat
cagttgaaaaaagtccagcttgagcacctcgaattcctagagaaacagaatgagcagctt
ttgaaatcctgtcacgcagtgtcccaaacgcaaggcgaaggagatgcagcagatggtgaa
attggaagcagagatggaccgcagaccagcaacagttgtgtgaaactccaggacgcaaac
tga

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