Bubalus bubalis (water buffalo): 102412823 Help Entry 102412823         CDS       T05912                                  Symbol SOS2 Name (RefSeq) son of sevenless homolog 2   KO K03099   son of sevenless Organism bbub  Bubalus bubalis (water buffalo) Pathway bbub01521   EGFR tyrosine kinase inhibitor resistance bbub01522   Endocrine resistance bbub04010   MAPK signaling pathway bbub04012   ErbB signaling pathway bbub04014   Ras signaling pathway bbub04062   Chemokine signaling pathway bbub04068   FoxO signaling pathway bbub04072   Phospholipase D signaling pathway bbub04150   mTOR signaling pathway bbub04151   PI3K-Akt signaling pathway bbub04510   Focal adhesion bbub04540   Gap junction bbub04630   JAK-STAT signaling pathway bbub04650   Natural killer cell mediated cytotoxicity bbub04660   T cell receptor signaling pathway bbub04662   B cell receptor signaling pathway bbub04664   Fc epsilon RI signaling pathway bbub04714   Thermogenesis bbub04722   Neurotrophin signaling pathway bbub04810   Regulation of actin cytoskeleton bbub04910   Insulin signaling pathway bbub04912   GnRH signaling pathway bbub04915   Estrogen signaling pathway bbub04917   Prolactin signaling pathway bbub04926   Relaxin signaling pathway bbub04935   Growth hormone synthesis, secretion and action bbub05034   Alcoholism bbub05160   Hepatitis C bbub05161   Hepatitis B bbub05163   Human cytomegalovirus infection bbub05165   Human papillomavirus infection bbub05200   Pathways in cancer bbub05205   Proteoglycans in cancer bbub05206   MicroRNAs in cancer bbub05207   Chemical carcinogenesis - receptor activation bbub05208   Chemical carcinogenesis - reactive oxygen species bbub05210   Colorectal cancer bbub05211   Renal cell carcinoma bbub05213   Endometrial cancer bbub05214   Glioma bbub05215   Prostate cancer bbub05220   Chronic myeloid leukemia bbub05221   Acute myeloid leukemia bbub05223   Non-small cell lung cancer bbub05224   Breast cancer bbub05225   Hepatocellular carcinoma bbub05226   Gastric cancer bbub05231   Choline metabolism in cancer Brite KEGG Orthology (KO) [BR:bbub00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     102412823 (SOS2)    04012 ErbB signaling pathway     102412823 (SOS2)    04014 Ras signaling pathway     102412823 (SOS2)    04630 JAK-STAT signaling pathway     102412823 (SOS2)    04068 FoxO signaling pathway     102412823 (SOS2)    04072 Phospholipase D signaling pathway     102412823 (SOS2)    04151 PI3K-Akt signaling pathway     102412823 (SOS2)    04150 mTOR signaling pathway     102412823 (SOS2)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04510 Focal adhesion     102412823 (SOS2)    04540 Gap junction     102412823 (SOS2)   09142 Cell motility    04810 Regulation of actin cytoskeleton     102412823 (SOS2)  09150 Organismal Systems   09151 Immune system    04650 Natural killer cell mediated cytotoxicity     102412823 (SOS2)    04660 T cell receptor signaling pathway     102412823 (SOS2)    04662 B cell receptor signaling pathway     102412823 (SOS2)    04664 Fc epsilon RI signaling pathway     102412823 (SOS2)    04062 Chemokine signaling pathway     102412823 (SOS2)   09152 Endocrine system    04910 Insulin signaling pathway     102412823 (SOS2)    04912 GnRH signaling pathway     102412823 (SOS2)    04915 Estrogen signaling pathway     102412823 (SOS2)    04917 Prolactin signaling pathway     102412823 (SOS2)    04926 Relaxin signaling pathway     102412823 (SOS2)    04935 Growth hormone synthesis, secretion and action     102412823 (SOS2)   09156 Nervous system    04722 Neurotrophin signaling pathway     102412823 (SOS2)   09159 Environmental adaptation    04714 Thermogenesis     102412823 (SOS2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     102412823 (SOS2)    05206 MicroRNAs in cancer     102412823 (SOS2)    05205 Proteoglycans in cancer     102412823 (SOS2)    05207 Chemical carcinogenesis - receptor activation     102412823 (SOS2)    05208 Chemical carcinogenesis - reactive oxygen species     102412823 (SOS2)    05231 Choline metabolism in cancer     102412823 (SOS2)   09162 Cancer: specific types    05210 Colorectal cancer     102412823 (SOS2)    05225 Hepatocellular carcinoma     102412823 (SOS2)    05226 Gastric cancer     102412823 (SOS2)    05214 Glioma     102412823 (SOS2)    05221 Acute myeloid leukemia     102412823 (SOS2)    05220 Chronic myeloid leukemia     102412823 (SOS2)    05211 Renal cell carcinoma     102412823 (SOS2)    05215 Prostate cancer     102412823 (SOS2)    05213 Endometrial cancer     102412823 (SOS2)    05224 Breast cancer     102412823 (SOS2)    05223 Non-small cell lung cancer     102412823 (SOS2)   09172 Infectious disease: viral    05161 Hepatitis B     102412823 (SOS2)    05160 Hepatitis C     102412823 (SOS2)    05163 Human cytomegalovirus infection     102412823 (SOS2)    05165 Human papillomavirus infection     102412823 (SOS2)   09165 Substance dependence    05034 Alcoholism     102412823 (SOS2)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     102412823 (SOS2)    01522 Endocrine resistance     102412823 (SOS2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RasGEF RasGEF_N RhoGEF SOS1_NGEF_PH PH RHG20_PH PH_19 Motif Other DBs NCBI-GeneID:  102412823 NCBI-ProteinID:  XP_006063211 LinkDB All DBs Position 11:60141093..60246223 Genome browser AA seq 1332 aa AA seqDB search MQQAPQPYEFYSEENSPKWRGLLVSALRKVQEQVHPNLSANEESLYYIEELIFQLLNKLC MAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGY KVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDD IGLVSLCEDEPSSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDRKLFKPSDI EKIFSNILDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDI LSPKFNEHFSKLMARPAVALHFQSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKI RSEEHEDRECLNQAITALMNLQGSMDRIYKQYSPRRRPGDPVCPFYNRQLRSKHLAIKKM NEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHSQSRLPG CSSAEYRLKEKFVMRKIQICDKEDTCECKHAFELVSKDENSIIYAAKSAEEKNNWMAALI SLQYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIK GGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTEADKLA LEKGEQPISTDLKRFRKEYVQPVQLRVLNVFRHWVEHHFYDFERDLELLERLESFISSVR GKAMKKWVESIAKIIKRKKQAQANGISHNITFESPPPPIEWHISRPGQFETFDLMTLHPI EIARQLTLLESDLYRRVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEA ENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILD DAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRR KVAEITGEIQQYQNQPYCLRIEPEMRRFFENLNPMGCASEKEFTDYLFNKSLEIEPRNCK QPPRFPRKSAFSLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPCKISFSRIAETELESTV SAPTSPNTPSTPPVSASSDLSVFLDVDLNSSCGSNSIFAPVLLPHSKSFFSSCGSLHKLS EEPLIPPPLPPRKKFDQDASNSKGTMKSDDDPPAIPPRQPPPPKVKPRVPAPTGPFDGPL HSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFTLQPPPLGHLHRDSDWFRDVSTCPNSPN TPPSTPSPRVPRRCYVLSSSQNNLAHPQAPPVPPRQNSSPHLPKLPPKTYKRELSHPPVY RLPLLENAETPQ NT seq 3999 nt NT seq  +upstreamnt  +downstreamnt atgcagcaggcgccgcagccttacgagttctacagcgaagagaacagtccgaaatggcgg ggactgttggtctcggccctgcggaaggttcaggagcaagtacatcccaatctctcagct aatgaagagtctctctattacattgaagagctgatttttcagctgcttaataaattatgc atggctcaaccaaggactgttcaagatgtggaggaacgagttcaaaagacctttcctcat ccaattgataaatgggctattgctgatgcacagtctgccatagagaaacgaaaaagaaga aatcctctcttactgcctgtggacaaaatccatccttcattgaaggaagttttagggtac aaagtggactaccatgtatccctgtatattgtggctgtgctggagtatatctcagctgat attttgaaattggctggtaattatgtttttaatatccgacattatgaaatatctcaacaa gacattaaagtgtcaatgtgtgcagataaggttttgatggacatgtttgatcaggatgac ataggcttggtttctctttgtgaagatgaacctagttcttcaggcgaattaaactactat gatcttgttagaactgaaattgcagaagaaagacagtatctacgggaactaaatatgatc ataaaagtgtttcgagaagcttttctttctgacagaaagctgtttaaaccttctgatatt gaaaagattttcagtaacattttagatatacatgaattgactgtgaaacttttaggttta attgaagacacagttgaaatgactgatgaaagtagccctcatcccttagctggcagctgt tttgaagatctggcagaggagcaagcatttgatccttatgaaacattatcccaggatatt ctttcaccaaagtttaatgaacattttagtaagttgatggccagacctgcagtggctcta cactttcagtccattgctgatggttttaaagaggcagttcgttatgtccttccacgcctt atgctggtgccagtatatcattgttggcactattttgaattattaaagcaattgaaaata cgtagtgaagagcatgaagacagagaatgtttgaaccaagctattactgctctcatgaat ctccaaggtagtatggaccgaatttacaagcagtattcacctagacgccgacctggggat cctgtttgccctttttataatcgtcaattaagaagcaagcacctggctattaaaaaaatg aatgaaattcagaaaaacatagatggatgggaaggcaaagatattggacagtgttgtaat gaatttattatggaaggcccattgacaagaattggtgctaaacatgaacggcatattttt ctctttgatggcttaatgattagctgcaaacccaatcacagccagtcacgccttccagga tgcagtagtgcagaatacagattaaaagaaaaatttgtcatgaggaaaatacaaatatgt gataaagaagatacttgtgagtgcaaacatgcttttgaattagtatccaaagatgaaaac agcataatatatgctgctaagtctgctgaagagaaaaataattggatggcagcacttatt tcccttcagtatcgtagtactcttgatcgaatgctagattcagtattattgaaggaagaa aatgaacaaccattgagattaccaagtcctgaagtgtatcgttttgtggtaaaagactct gaggaaaacattgtttttgaggacaacttgcagagtagaagtggaatccccattattaaa ggaggaactgtggtgaaattaattgaaaggctaacatatcatatgtacgcagatcccaat tttgttcgtacttttcttactacatatcgttcattttgtaaaccacaggaattactaagc ttactgattgaacgatttgaaattccagagccagaacctactgaagcagataaattggca ttagaaaaaggcgagcagcccatcagtacagaccttaaaaggtttcgcaaggaatacgtc caaccagtacaacttagggtcttaaatgtgtttcggcactgggttgaacaccatttttat gactttgaaagagacttggagctgcttgaaagactagaatccttcatttcaagtgtaaga gggaaagctatgaagaaatgggtagagtcaattgctaagatcatcaagaggaaaaaacaa gctcaggcaaatggtataagccataatattacctttgaaagtccacctccaccaattgaa tggcatatcagcagaccaggacagtttgaaacatttgatctcatgacacttcatccaata gaaattgcacgtcagctgacccttttggaatctgatctctacaggagagttcaaccttct gaacttgtagggagtgtatggaccaaagaagataaagaaataaattctccaaatttatta aaaatgattcgccacaccacaaatctcaccctctggtttgaaaaatgcattgtggaggca gaaaattttgaggaacgagtggcagtactgagtagaattatagaaattctgcaagttttt caagatttgaataatttcaatggtgtattggagatcgtcagtgcagtaaattcagtatca gtctatagactagatcatacctttgaggcgttgcaggaaagaaaaaggaaaattttggat gacgctgtggaattaagtcaagatcattttaaaaaatatctagtgaaacttaagtcaatc aatccaccctgtgtgcctttttttggaatatatttaacaaatatactgaagactgaagaa gggaataatgattttttaaaaaagaaagggaaagatttaatcaatttcagtaagaggagg aaagtagctgaaattactggagaaattcagcagtatcaaaatcaaccttactgtttacgg atagaaccagaaatgaggagattctttgaaaaccttaaccccatgggatgtgcttctgaa aaagagtttacagattatttgttcaacaagtcactagaaattgaaccccgaaattgcaaa cagccacctcgatttcctaggaaatcagctttctccttaaaatctcctggaataaggcct aatacaggccgacatggctctacctcaggtactttgcgaggtcacccaacaccattagaa agagaaccgtgtaaaataagctttagtcggattgctgaaacggagcttgaatcaacagtg tcagcaccaacctctccaaatacaccatctaccccgccagtgtctgcttcttcagacctt agtgtgtttttagatgtggatctcaacagttcctgtggaagcaatagcatctttgcccca gtcctcttgcctcattcaaagtctttcttcagttcgtgtggtagtttacataagctaagt gaagagccactgattcctcctccacttccacctcgaaaaaaatttgatcaggatgcttca aattccaagggaactatgaaatctgatgatgacccccctgctattccaccaagacaacct cctcctccaaaggtaaaacccagagttcctgctcctactggtccatttgacgggcctctg catagtccacctccaccgccgccaagagatcctcttcctgatacccctccaccggttcca cttcggcctccagaacactttataaactgtccgtttacccttcagccacctccactggga catcttcacagagattcagactggttcagagacgttagtacgtgtccaaattctccgaac actcctcctagcacaccctctccaagggtacctcgtcgatgctatgtgctcagttctagt caaaataatcttgctcatcctcaagctccccctgttccaccaaggcagaattcaagccct catctaccaaaactgccaccaaagacttacaaacgggagctttcacaccccccagtgtat agactgcctttgttagaaaatgcagaaactcctcaatga

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