Bubalus bubalis (water buffalo): 102413153 Help Entry 102413153         CDS       T05912                                  Symbol SYNE1 Name (RefSeq) nesprin-1 isoform X1   KO K19326   nesprin-1 Organism bbub  Bubalus bubalis (water buffalo) Pathway bbub04820   Cytoskeleton in muscle cells Brite KEGG Orthology (KO) [BR:bbub00001]  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     102413153 (SYNE1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:bbub03036]     102413153 (SYNE1) Chromosome and associated proteins [BR:bbub03036]  Eukaryotic type   Centrosome formation proteins    LINC complex     102413153 (SYNE1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Spectrin Spectrin_SYNE1 SYNE1 CH KASH Spectrin_SYNE1_2 SYNE3 Motif Other DBs NCBI-GeneID:  102413153 NCBI-ProteinID:  XP_044780007 LinkDB All DBs Position 10:14496318..14991250 Genome browser AA seq 8826 aa AA seqDB search MATSRAASRAPRDIANVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDG VKLLALLEVLSGQKLPCEQGRRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPS IVLGLMWTIILYFQIEELTSNLPQLQALSSSTSSVDSMVSSETASPPSKRKVATKIQGNA KKALLNWVQYIVTKQSGIEVKDFGRSWRSGVAFHSVIHAIRPELVDLEKVKGRPNRENLE EAFTIAETELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKQYPDIHSTGSDGQENDEILP SFPSFTNSIQILKREDRLILKEMKVWIEQFERDLTRAQMTDSSLQDKYQSFKHFRVQYEM KRKQIEHLLQPLHRDGKLSLDQALVKQAWDRVSSRLFDWHIQLDKSLPAPLGTIGAWLYR AEVALREEITIQQVHEETANTIQRKREQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPD QLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGGRDSVELLL QNYISFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVE VRSVRSMLEEVIANWDRYGNTVTSLQAWLEDAEKMLNQSEHAKKDFFRNLPHWIQQHTTM NDAGNFLIETCDEIVSRDLKQQLLLLNGRWRELFMEVKQYARADELDRMKKEYNDCVTIL SDFATEAHRKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKMITKTVHLITKEISQE EANEMFATMSGLKEQLTKVKDCYSPLLSESQQLLVPLEELEKQMTAFYDSLGKIDEIMTV LEHEAQSSPLFKQKHQELLACQESCKKAMTQIEKGSQSVQKFVTLSNVLKHFDQMKLQRK IADMHVAFQNMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRVAQEGLEEKGDPEDLL KRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQRGLQEAVRKLHKQWKDLQAEAPYHLL HLKIEVEKNRFLASVEECRAELDRETKLVPQEGSEKIIKEHRIFFSDKGPHHLCEKRLQL IEELCLKLPVRDAVRNTPETCHVTLKELRAAIDCTYVKLVGDPDKWKDYTSRISEFSSWI SAKETQLKGIKNETIDTANQGEVKRALEEIRSGITKKGETLSWLKSRLKILIEVSSEDEA QKQGDELAKLSSSFKALGTLLSEVEKMLSNFGDCVQYKEIVKSSLEELITGSKEVQEEAE KILDTENLFEAQQLLLHHQQKTKRINAKKKDVQQQITQAQKREGGLPGRVQEELQKLEST LDSVEHSREKQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELE QTKEFSKRTEGIAVQAENLVKEASEIPLGPKNKQLLQQQAKSIKEQVKKLEDTLEEDIKT MEMVKNKWDHFGTNFETLSVWITEKEKELNALETPSSAMDTQINQIKVMIKEIESKISSI TGLEEEAQSFAQFVTTGESARIKAKLTQIRRYWEELREHAQSLQGIILGHLSQQQKFEEN LKKIQQSVSEFEDKLADPVKICSSATETYKVLQEHMDLCQALESLSSMVAALSASARKVS NRDSSIQEATTVQQSYEGLLGRAKERQTELENLLARWQRLEKELSTFLTWLERCEAIASS PEADISADRVKVESELQSIQVLQNEVVSQASIYSNLLQLKESLFSVASKDDVKMMKLQLE QLDERWRDLPQIISKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQ AALTRHKDHAAEVESKKGELQSLQGHLAKLGALGRAEDLHLLQGKAEDCLQLFEEASQVV ERRQHALSQLAKFLQSHASLSESLHQLRQTVEATHSMNKKQSDLLERDLNDAIQNVKTLE SAAISLDSLLTKAQYHLKSGDSEQRTSCRATSDHLSMELERIQNLLGTKQSEADALAVLK KAFRDQKEELLKSIEDIEERTDKERLKDLTRQALQQRLRVFNQLEDELNSHEHELCWLKD KAKQIAQKDVAFAPEVDKEINRLEVTWDDTKKLIHENQGQCCGLIDLMREYQNLKSAITK VLENASNVIATRTTVKDQEDLKWALSKHEAAKNEMCNKQKDLDNFTSKGKQLLSELKKIH SGDFIVVKTDMESTVDKWLDISEKIEENMDRLRVSLSIWDDVLTSKDEIDGWSNHSVPQL TESISNLNDSLRAEESLKEFESEVKKKALRLEELHSKVNDLKELTKNPETPPDLQFIEAD LRQKLEHAKEIAEEAKGTLKEFTAQSAQVEKFINDTATWLTKLEESLMNCAQTETCEGLK KVKDIQKELQSQQSNISTTQENLNSLCRKYHSVELGSLGSAMTGLIKRHEAVSQSCSKTQ ASLQDSLEKHFNESMQEFQEWFSGIKAAAKESSDRTGDSKVLEAKLRDLQNILDSVSDGQ SKLDAVTREGQTLYAHLSKQIVSSIQEQVTKANEEFQAFLKQCLKDRQALQDCALELGSF EDQHRKLNLWIHEMEERLSTENLGESKQHIPEKKNEVHKIEMFLGELLAARESLDKLSQR GQLLSEEGHGAGKESRLCSQLLTSYQNLLRMTKEKLRSCQVALQEHEALEEALQSMWSWV KDMQDRLASAESTVGSKDALERRLLQVQEILLMKGEGEVKLNMAIGKGEQALRSSNEEGQ KVIQTQLQTLKDVWANIMGSSVHAQSTLESVISQWNDYLEWKNQLEQWMESVDQKVEHPL QPQPGLKEKFSLLDHFQSVVSEAEDHAGALQRLTAKARELYQKTEDEALTDTAQEELKTQ FNDILTVSKEKMKKVEEIVKDHLMYLDAVQEFTDWLHSAKEELHRWSDMSGDSPATQKKL SKIKELMDSREIGASRLSRVESLAPAVKRNTTASGCELLDTEMQALRADWKQWEDSVFQT QTSLENLVSQMALSEQEFSGQVAQLEQALEQFSALLTSWTQQLALLEGKNTDKELVECWQ KGREILDALQKAEPHTENLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQN KEQILQQRFLRAFKDFQQWLVNAKITTAKCFDIPQNINEVSTSLQKIQEFFSESENGQHK LNTMLSKGELLCTLLTKEKASSIQAKIATAKEDWKNFHSNLHQKESSLENLKIQMKDFEV SAEPVQDWLSKTEKMVHESTNRLYDLPAKRREQQKLQSVLEEINCYEPQLRRLKEKAQQL WEGQAASRSFMHRVSQLSSQYLALSNVTKEKVSRLDRIVAEHNQFSLGIKDLQDWMTDTV HMLDSYCHPTSDKSVLDSRMLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPAIQ QQLASVKDMWASLLSAAIRCKSQLEGALSKWTSYQDDVRQFSSWMDSVEASLNESERQHA ELREKTAALGKAKLLNEEVLSHGSLLETIEVKGAGMTEHYVTQLEFQDLQERYGAIRERT KEAVTKSEKLVRLHQEYQRDLKAFEAWLEKEQDKLDRYSVLEGDAHTHEMALRDLQELQV RCAEGQALLNSALHTREEVIPSGIPQTEDRALESLRQDWQAYQQRLLETRTQFNNVVNKL RLVEQKFQQVDEWLKTMEEKVSLRTARQSSRAAKEMQLHQMKKWHEEITAYRDEVEEVGA RAQEILDESHVSSRMGCQATQLTSKYQALLLQVLEQIKFLEEEIQSLEESELSLSSYSDW YSSTHKNFKNVAAKIDKVDKAMMGKKMKTLEGLLKDMEKGQSLLKSAREKGERALKYLED AEAETLRKEIHDQVERLKELTSTVRKEHMTLEKGLHLTKEFSDKYKALTQWIAEYRDILH GPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQ SDYQDLCSAAKEHVCSLEAKVRDHEDYNSELQEVEKWLLQMSGRLVAPDLMETSSLETIT QQLARHKAMMEEIAGFEDRLNDLKTKGDNLISQCADHLQAKLKQNVHAHLQGTKDSYSAI CSTAQRVYQSLEHELQKHVSRQDTLQQCQAWLSVVQPDLKPGANPPLSRAEAVKQVKHFR ALQEQARTYLDLLCSMCDLSNSSVKTTAKDIQQTEQMIEQRLAQAQNLTQGWEEIKHMKA ELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQCKQASVNTITEKVDELT KKQESPEHKEISHLNDQWLDLCLQSNNLCLQREEDLQRTRDYHDRMNIVEGFLEKFTTEW DNLARSDAESTAVHLEALKKLALALQERKKAIEDLKEQKQKMIEHLNLDDKELVKEQTSH LEQRWFQLEDLVKRKIQVSITNLEELSVVRSRFQELMEWAEEQQPNIAEALKQSPPPDMA QNLLMDHLAICSELEAKQMLLKSLTKDADRVMADLGLNERQIIQKALSDAQRHVSSLSDL VGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQ ASLKTYQNEVTGLWAQGRELMKGVTEQEKSEILGKLQELQSVYDTVLQKCSHRLQELEKN LVSRKHFKEDFDKACHWLKQADIVTFPEINLMNETAELHTQLAKYQHILEQSPEYENLLL SLQRTGQAILPTLNEVDHSYLNEKLHALPLQFNVIVDLAKDKFYKVQEAMLARKEYASLI ELTSQSLHDLEDQFSRMSQIPGHLSVEEALSLRDGWQALGGEVAGLAEAVDELNQKKESF RSTGQPWQPDKMPQLVTLYHRLKRQTEQRVSFLEDTTSAYQEHEKMCLQLEKQLEAVRTE QSKVNEETLPAEEKLKVYHSLAGNLQNSGILLKRVTRHLEDLVAHLDPAAYEKSKHQLQA WQEELKLLTSAIGATVTECESRMVQSRDFQTELSRSLEWLRSVEVALSGPLCLDPNLRDI QEEIRKVQIHQEEVQSSLRIMNALSNKEKEKFTRAKELISADLQRTLAELSELDGALQEA LRTRQTTLTQIYSQCQRYYQVFQAANDWLEDAHEMLQLTGNGLDVESAEESLKSHMEFFS AEDQFHSNLEELQGLVAKLDPLIKPNGKEDLAQKMASLEEKSQTIMQDSHAQLELLQRCA AQWQDYQKAREEVIELMNEAEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVINSFHEKIV ALEGEASELERTGNDASKAAISRSTTAVWQRWTRLRAVAQDQEKLLEDAVDEWTSFNNKV KKASEMIDQLQDKLPGSSAEKASKAELVTLLEYHDTFILELERQQSALGMLRQQALSMLQ DGVTPSPGGEPPTVQEITAMQDRCLNMQEKVKKNGKIVKQELKEREVVETHISSVKSWVQ ETKEYLGNPTIEIDAQLEELKILLTEAINHQQNVEKMAEEQKNKYLGLYTILPSELSLQL AEVALDLGTTHDQIQDKVKEVEQSKAMSQEFSQQIQKIARDLTTILTKLRAKTDNLVQAK TDQKVLGEELDGCHLKLMELDKAVQKFSEQNSQLGKPLAKKIGKLTELHQQTIRQAENQL SKLNQAASHLEEYNEMLELILRWIEKTKILVHGKIAWNSASQLREQYISHQTMLEESEDI HNDLEAMTEKLQYLDSVYHTETMSQQVADLGRETEELRQVIKIRLQSLHDAAKDMKKFEA ELRNLQVALEQAQTTLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVHAVQVCQSVLRIP EDVVTSLPLCHAALHLQEEASRLQHTAIQQCNIMQEAVVQYEQYEQEMQHLQELIEGAHR EIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVT EVEGLAEGTEDLDGELLPATSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPAC RSPSPVANTDASVNQDIAYYQALSPERLQTDAAKVPPSTLPPQELYEPGLEPSATAKLDD LQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIEMKLSESLEQGRSPESQ MAEHQSSPQALMDEILMLQEEISELQSALADELVSGSPESEPAEQLALQSTLTVLAERMS TIKMKASGKRQLLEEKLNDQLEEQRQEQALHRYRCEADQLDHWLLSTKATLDIALGSPKE PMDMEAQLVDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAVKLRTLKGS LLELQRALQDRQLHIQQGTAQEKEESDADLAATQSPGVQEWLAQARSAWTHQRQSSLQQQ KELEQELAEQKSLLQSVASLGEEILTQHSAAETSGGVGEKPDVLSQELGMEGEKSPAEDQ MRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDGQAQDKSAVTSL LDGLNQVFEEVSSQGGGTKKQNVDLEQKLYDGVSATSTWLDDVEERLFVATALLPEETET CIFNQETLAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQ RCHQMKERLQQILNFQNDLKVLVTSLADHKYIILQKLAKMFEQPVAEQIEAIQQAEDGLK ELDAGIIELKRRADKLQIEQPSMQELSKLQDMYDELMMTIGSRRSGLNQNLALKSQYERA LQDLADLLETGREKTAGDKKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISF AVPRETQFHTDLMAQASAVLKGAHKRGVELEYILETWSQLEKEHWELSRQLEVVESSTPS VGLVEESEDRLIDRIALYQHLKSSLNEYQPKLYQVIDDGKRLLISVSCSDLESQLNQLGE HWLSDTNKVSKELHRLETILRHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEM VRDHLNGFLEFSKEVDAKSTLKSSVLSTGNQLLRLKKVDTAALRSELSHIDGQWNDLLTN IPAVQEKLHQLQMDKLPSRHAISEVMTWISLMESVIQKDEENIKNSIGYKTIHEYLQKYK GFQIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAERLGAMNKSWQILQGLVTEKI QLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNAMKDCQDLEDLIKAK EKEVEKIEQNGLALVQNKKEEVSGIVRSTLQELNQTWANLDHMVGQLKILLKSVLDQWGH HKVAFDEINSCLMEARYSLSRFCLLTGSLEAVQVQVDSLQNLQDDLEKQEKSLQKFGSVT NQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLRASKALLQLWQRYKDYFKQCAAT VQQQEGRTNEFLKAATDKDIGDDEVATWIQDCNDLLKGLGPIQDSLVVLHELGGQLKQQV DASAASAIQSDWVSLRQQLHALEQALCKQQTVLQAGVLDYETFTKSLEALETWIVEAEEI LQGQDPSHSSDLSTIQERMEELKGQMLKFSSMVPDLDRLNELGYRLPLNDKEIKRMQNLN RHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQ RAHELFQAEMFSRQQILHSIIFDGQHLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQR RGIIDSQIHQWQRYREMAEKLRKWLVEVSCLPVSDLGSVQIPLQQARALFDQVQFKEKVF LRQQGSYILTVEAGKQLLLSADSGAEATLQAELAEIQEKWKSASVCLEEQKKKLSGLLQD WEKCENGIADSLKKLRTFKNRLSQPLPDHHEELHAEQMCCKELENAVGSWTDDLAQLTLL KKALCAYISADDISILNERMELLQRQWEELCHQLSLRRQQVSERLNEWAVFSEKNKELCE WLTQMESKVSQNGDILIEEMIEKLRKDYQEEIAIAQENKIQLQQMGERLARASHESKASE IEYKLGKINDRWQHLLDLMAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVY DSCDSEEIQKKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATR NLDRRWRNICAMSMERRLKIEETWRLWQKFLDDFSHFEDWLKISERTAAFPSSSGVLYTV AKEELKKFEAFQRQVHESLTQLELINKQYRRLARENRTDAAGSLKQMVHKGNQRWDNLQK RVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQ EISLNHSKIEQIIAQGEQLIEKSEPLDAAVIEEELDELRRYCQEVFGRVERYHKKLIRLP LPDDEHDLSDRELELDEAGALSDLHWRDTSTDGVLSPQPSSNPSLSLAQPLRSERSGRDT PASVDSIPLEWDHDYDLSRDLESAVSRTLPSEDEEGPEDKDFYLRGAVGLSDVVIPESPE AYVKLTESAIRNSSGDPGALESQIRQLGKALDDSRFQMQQTENIIHSKTPTGPELDSGYR GYMKLLGECSGSIDSVKRLEHKLTEEEDHFPGFVNLNSTETQTAGVIDRWELIQAEALSK ELRMKQKPQRRQQLDSDLNSVLTWLQETEGDLEQLQRLQLSTDIQSIAFQIQKLKELQKA VDQRKAIILSIHLCSSEFTQPGREESQDLQDRLSQMNGRWERVCSLLEEWRGLLQDALMQ CQDFHEMSHSLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLKQIRHELLESQLKVAS LQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDMSSSQQDLSS WSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVNSPHSRSIKGGSDSSLSEP RPARSGRAFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCALSNNFARSFHPMLRYT NGPPPL NT seq 26481 nt NT seq  +upstreamnt  +downstreamnt atggccacctccagggcagcctcgcgggcccctcgggacatcgccaatgtgatgcagagg ctgcaagatgagcaagagatagtacaaaaacgtactttcacaaaatggatcaactctcat ctggccaagcggaaacccccaatggtggtagatgatctttttgaagacatgaaagatggt gtgaagctacttgctctgctggaagtcctgtctgggcagaaactgccatgtgaacaaggg cgccggatgaagagaattcatgctgtggcaaacattggcacagcactgaagttccttgaa ggaaggaagattaaactagtcaacattaactccactgatatagctgatggtcgaccctcc attgttctcggattgatgtggaccattatcctgtatttccagatcgaggagttgaccagc aacctgccccagctgcaggctctgtccagcagcacgtcctccgtggacagcatggtcagc tctgagaccgccagccccccgagcaaacggaaggtggccacaaagatccaaggaaacgct aagaaggcgctattgaactgggtccagtacatagtcaccaagcagagtggaatagaagta aaagacttcggccggagttggagaagtggagtggcctttcattctgtcatccacgctatt cggccggaactagtggacctggagaaggtgaaaggaaggcctaaccgagaaaacctggag gaggctttcaccattgctgaaacggaactggggatcccacggctcctggaccctgaagat gttgatgtggataaaccagatgagaagtctattatgacctatgtggcccagtttctgaag cagtatcctgacatccacagtacaggctctgatgggcaagagaatgatgaaatacttcca agtttcccatcttttacaaattctatccaaattcttaagagagaagacaggctaattttg aaggagatgaaagtttggatagaacaatttgaaagagatttgacaagggcacagatgaca gactcaagtttgcaggataaatatcagtcatttaagcatttcagagttcaatatgaaatg aagaggaaacagattgaacacttattgcaaccattacatagagatggtaaattgtcactt gaccaagcattggtaaaacaggcctgggatagagtgtcctccaggctcttcgattggcat atacaacttgataagtctcttcctgcacctctgggcaccataggggcctggttatacaga gcagaggtggccctaagagaggaaataaccattcagcaggttcacgaggaaacagccaac acaatacaacggaaacgtgagcaacacaaggatctgcttcaaaacacagatgcccacaaa agagcattccatgaaatctaccgaaccaggtctgtgaacgggatcccagtgccgcctgat caattagaggacatggccgagaggtttcattttgtttcctccacatcagagctacactta atgaaaatggaatttctagaattaaagtaccgtctgctctcactgctggttcttgcagag tcaaagctgaagtcttggatcatcaagtatgggggcagagactcagtggagctacttctg caaaactacatctcttttatagaaaacagcaagttctttgaacaatatgaagtgacatac cagatcttgaaacagacagctgagatgtatgtcaaagctgatggttcagtggaagaagct gagaatgtgatgaaattcatgaatgaaaccactgcccagtggaggaacctctccgtggaa gtcaggagtgtgcgaagcatgctggaggaagtcatcgccaactgggaccgatacggcaat accgtgactagtcttcaggcttggctcgaggatgctgaaaaaatgctaaatcagtcagaa catgccaaaaaggattttttccgaaatttgcctcattggatacagcagcacactaccatg aatgatgctggcaattttttaatcgaaacctgtgatgagatagtttcccgtgatctcaaa cagcaattactgttgctaaatgggcgatggagggagttgtttatggaagtcaagcaatat gctcgagctgatgagttggacagaatgaagaaagaatacaacgattgtgttactatcttg tctgattttgcaactgaagcccataggaaactttcagagcccttagaagtctcttttatg aatgtcaagttattaattcaagacttggaggatattgaacagagggtgcctgtgatggat gctcagtataagatgataacaaagacagtgcacctcattaccaaagagatctctcaagaa gaagctaatgaaatgtttgcaaccatgtctgggctcaaagagcaactaaccaaggtcaaa gactgttactccccactcctttctgagtctcagcagctgttggtaccgttggaggaatta gaaaagcagatgacggccttttatgactcacttgggaaaatcgatgaaattatgacagtt cttgaacatgaggcacaatctagtcctctttttaaacagaaacatcaggaactgttggct tgtcaagaaagctgtaagaaagccatgactcaaattgagaaaggcagtcaaagtgttcag aagtttgtgaccttgagcaacgtgttaaagcattttgatcagatgaagctacagagaaag attgcagatatgcatgttgcttttcagaatatggtaaagaaaactggagattggaagaaa catgtggaaaccaacagccgcttgatgaagaagtttgaggagtctcgagccgagttggag aaggtgctcagggttgctcaggagggcctggaggaaaagggggacccagaagacctgctg aagagacacaccgagtttttcagtcagctggaccagagggtgctcaatgctttcctgaaa gcgtgtgacgagctcactgacattctgcctgagcaggagcagcggggcctgcaggaagcc gtcagaaagctccacaaacagtggaaggatcttcaagcagaagctccatatcatttgctt catctgaagattgaggtggagaagaacaggttcttagcttctgtggaagagtgcagagct gagctggaccgagagaccaagctggtgccccaggaaggcagcgaaaaaatcatcaaagag cacaggattttcttcagtgacaagggccctcaccatctctgtgagaaaaggttacagctc attgaagaactgtgtctgaaacttccagtccgggatgcagtccggaacacacctgagacc tgtcacgtgaccctcaaggagctcagagctgctattgactgcacctacgtgaagctggtg ggagacccagacaaatggaaggactacacgagcagaatttctgagttctcctcttggata tctgcaaaggagacccagttaaaggggattaagaatgagaccattgatactgctaatcaa ggagaagttaaacgtgctctggaggagatcagaagtggtattaccaaaaaaggggagact ctcagctggctgaaatccaggcttaaaattctgattgaagtttcttctgaggatgaagcc caaaagcaaggagatgagctggcaaaattatctagttctttcaaggctctcgggactttg ttgtcagaggttgaaaagatgttaagcaactttggagactgtgtccagtacaaagaaata gtcaaaagttccctggaagagttaatcactggctctaaagaagtccaggaagaagccgag aagatcttggacactgaaaatttgtttgaagcacaacaactactccttcatcaccagcaa aagacaaagaggatcaatgcaaagaagaaggacgtgcaacaacagatcacgcaggctcag aagagagaaggtgggctgcctgggcgagtccaagaggagctgcagaagctggagagcacc ctggacagcgtggagcacagtcgggagaaacaggagcgccgcatccaggtcacattaaga aaatgggagagatttgaaacaaacaaagagacagtggtcagatacctttttcaaacaggt tccagccatgagcgcttcttgagttttagcagtttggaaagcttatcttcagaattggaa cagacaaaggagttttctaaacgcacagaaggtattgcagtccaggctgagaatcttgtg aaggaagcttcagagatcccacttgggcccaagaataagcagctgcttcagcagcaggcc aagtcaatcaaggagcaagttaaaaaattagaagacacccttgaagaagatattaaaacc atggaaatggtgaaaaacaagtgggatcattttggcactaactttgagaccctgtccgtc tggataactgagaaagaaaaagaactcaatgccttggagacgccgtcatctgccatggat acacaaatcaaccaaattaaggtcatgattaaggaaatagaaagtaagatcagcagcatt 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gttggacgtctaagtctcaaagagcaactctctcaccgacagcatttgctgtctgagatg gagtcactcaagccaaaagtccacgcggtgcaggtctgtcagagcgtgctccggatcccc gaggacgtggtcaccagcctgccgctctgccacgcggctctgcacctgcaggaggaggcc agccggctccagcacacggccatccagcagtgcaacatcatgcaggaggctgtggtgcaa tatgaacaatatgagcaagaaatgcagcacctccaggaactcatagaaggagctcacaga gagattgaggataagcctgtggccaccagcaacatccaggaactgcaagcccagatttct cggcatgaggagctggctcagaaaatcaagggctaccaggagcagatcgcctctttgaac tccaagtgcaagatgctgaccatgaaagccaagcacgccaccatgctgctgacggtgacc gaggtggaggggctggcggagggcacggaggacttggacggggagctcctccccgcgacc tcggcccacccctctgtggtcatgatgactgcaggtcgctgtcacactttgctgtcacct gtcactgaggagtctggggaggagggaaccaacagtgagatctcctctccgcctgcttgc cgctccccttcacctgtggctaatacagatgcctctgttaaccaggacatcgcttattac caagccttatctcctgagaggttacagaccgatgctgccaaggttccccccagcacgctg ccaccccaagagctctatgaaccaggactggagccttccgctactgcgaagctggacgat ttgcagcgctcttgggaaaccttaaagaatgtgatcagcgagaagcagcgcacactctat gaagccttggaacgccagcagaagtaccaggactccctccagtccatctccacgaaaatg gaggccatcgagatgaaactcagtgagagtctggagcagggcaggagtcccgagagccag atggccgaacatcagtcttcccctcaggctctgatggatgagatcctcatgctccaagag gagatcagcgagctgcagtcggccctcgcagacgagctggtgtccgggtccccggagtcc gagccggcagagcagctggccctgcagtccacgctcaccgtcttggcggagcgaatgtcc accatcaagatgaaggcatccgggaagcggcagcttctggaggagaaactcaacgatcag ctggaggaacagagacaggaacaagccctgcacaggtatcgctgtgaagctgatcagctg gaccactggctcttgagcacgaaggccactctggacattgccctggggtcacccaaggag cccatggacatggaggcccagttagtggactgccagaatatgctggtggaaatagagcag aaggtggtggccttatcagagctctctgtccacaatgaaaacctgctgctggagggcaag gctcacacaaaggacgaggccgaacagctggcggtgaagctgagaaccctcaaggggagc ctcctggagctgcagagggcgctgcaggacagacagctccacatccagcaggggacagcc caggagaaggaggagagcgatgctgacctggctgccacacaaagccccggggttcaggaa tggctggctcaagctcggagcgcatggacccaccagcgacagagcagcctccagcaacaa aaagagttggaacaggaattggcagagcagaaaagcctcctccagtcagtagccagcctt ggagaggaaattctaacgcaacactcagctgcagagacctctggtggtgttggcgaaaaa cctgatgtgttatcccaggagttggggatggaaggggagaaatcacctgctgaagaccag atgagaatgaaatgggaaagcctacatcaagaatttagcaccaagcagaaactacttcag aatgttctggagcaggaacaagagcaagtgctctacagcaggcccaatcggctcctgtct ggcgtgccactgtacaaaggggacggacaggcccaggataaatctgcggtgacgtctttg ctggatggattgaaccaggtcttcgaggaggtttcatcccagggtggagggacaaagaag cagaacgttgatttggaacagaagttgtatgatggggtctcggccacctctacctggctg gatgatgtagaggaacggttatttgttgccacagcccttttaccagaagagacggaaact tgcatcttcaaccaagagactcttgccaaagatattaaggaaatgtctgaagaaatggat aagaacaagaacttgttttcccaagcctttccggagaatggtgataaccgagatgttatt gaagacactttgggttgtctcttgggcaggttatctttgctagattcagtagtaaatcaa cgatgtcatcagatgaaggaaagacttcagcagatactaaatttccagaatgatctgaag gtgctagttacatcactggctgaccacaaatacatcattctgcagaagctggcgaaaatg tttgaacaacctgtggcagagcaaatagaggcaatacagcaggctgaagatggactaaag gaattagatgcgggaatcattgagttaaaaaggcgtgctgataaattgcagattgagcag ccttccatgcaagaactctccaaactccaggacatgtatgatgaactcatgatgactatt ggctcccggcggagcgggctgaaccagaatcttgccctcaagagtcagtacgaaagagcc ttgcaggatctggccgacctactggaaacaggacgagagaagacagcaggagacaagaaa attattgtgtcttccaaagaggaaatccaacaactacttgataaacataaggaatacttt cagggtctggaatctcacatgatcttgaccgaaaccctcttcagaaagatcatcagcttt gcagtcccacgggaaactcagttccacacagacctgatggcgcaggcttccgccgtgctc aaaggggctcacaagaggggtgtggagctggagtacatcctcgagacatggtcccaactg gagaaggagcactgggagcttagccggcagctggaggtggtggagagcagcaccccaagc gtgggtttggtggaggagagcgaagacaggcttatcgaccggatcgcactctaccagcat ttgaaatccagccttaatgaataccagcccaaattatatcaggtaatagatgatggaaaa cgacttctgatatctgttagctgttcagatctggaaagccagctaaatcaacttggagag cactggttaagtgataccaacaaagtgtctaaggaacttcacagattggaaacaatattg agacactggaccagatatcaaagcgaatctgcagatctaatccactggttacagtctgca aaagacaggctggaattttggactcaacaatctgtgacagtcccacaagaactggaaatg gtccgtgatcacctgaatggctttctggagttttccaaagaggtggatgccaagtccacg ctaaaatcatctgttctgagcactggaaatcagcttcttcgattaaagaaagtggacaca gctgccttgcgttctgagctgtcccacattgatggccagtggaatgacctgctgacaaat attccagccgtacaggaaaagcttcaccagctccaaatggataaactgccttctcgccac gccatttccgaagtcatgacttggatttctcttatggaaagtgttattcaaaaggatgaa gagaatattaaaaattccatcggttacaagacaattcatgagtaccttcagaaatataag ggttttcagatcgacattaactgtaagcagctgactgttgattttgtgaatcagtctgtg ctacagatcagcagtcaggatgtggaaagtaaacgcagtgacaagactgattttgctgag cgacttggagcaatgaataaaagctggcaaatcctgcagggtctggtcactgagaagatt cagttgttggaaggcttattggaatcttggtcagaatatgaaaataatgtacaatgtctg aaaacgtggtttgaaacccaggaaaagagactgaaacaacaacatcgcattggagaccag gcttcagttcagaatgcaatgaaagactgtcaggatctggaagacttgattaaagcaaaa gagaaagaggtagagaaaattgagcagaatggacttgctttggttcagaacaagaaagaa gaagtctctggcattgtcaggagcacgcttcaggagctcaaccaaacttgggcaaattta gaccacatggttggccaactcaagatcctgttgaaatccgtgcttgaccagtggggccat cataaagtggcgtttgatgagataaacagttgcctcatggaggcccgatactctctttct cgattctgtctactcactggctctttagaagctgtgcaagttcaggtggacagtcttcag aatcttcaagatgatctagaaaaacaggaaaagagcttgcagaaatttggctctgtgacc aatcaacttttaaaagaatgtcacccacctgtgacagaaactcttactaatacactaaaa gaagtcaacatgagatggaataacttgctggaagagattgccgagcagctgcgtgccagc aaggccctacttcagctttggcagagatacaaggactacttcaaacaatgtgctgctaca gttcaacagcaggagggacgaaccaacgagttcttgaaggcagccaccgacaaggacatc ggtgatgacgaagttgccacctggatccaagattgcaatgacctcctcaaaggattgggg ccgattcaggattctcttgtagttcttcatgagctgggagggcaactcaagcaacaagtg gacgcttcggcagcatcagccattcaatccgattgggtctctttgaggcaacaattacat gccctcgaacaggctctctgcaaacagcagactgtgttacaggctggcgttcttgactat gaaacctttaccaagagtttagaagctttggagacctggatagtagaagctgaagaaata ctacaagggcaggaccctagccactcctctgacctctcgaccatccaggaaaggatggag gagctgaagggacagatgctgaaattcagcagcatggtcccagatttagaccgtctgaat gagcttggatacaggctgcccctgaacgataaagaaatcaaaaggatgcagaatctcaat cggcactggtctctgatctcctcccagactacggaaagattcagtaagttacagtcattt ttgctacaacatcagactttcttggaaaaatgtgaaacatggatggaattcctagttcaa acggaacaaaagttagcagtagagatttcaggcaattatcagcatcttttggagcagcag agagcacatgagttgtttcaagcagagatgttcagccgtcagcagattttgcactcgatc atttttgatggacagcaccttctagaacaaggtcaagttgatgacagggatgagttcaac ctgaaactgaccctcctcagtaatcagtggcagggggtgatccgccgggctcagcagagg cggggcatcattgacagccagatccaccagtggcagcgctacagggagatggcagaaaag ctccgtaaatggctggtggaggtgtcctgtctgcccgtgagtgatctgggcagtgtccag ataccactgcagcaggcaagggccctctttgatcaagtgcagttcaaagaaaaagtgttc ctgcggcaacaaggtagctacatcctcactgtggaggctggcaagcagcttctgctttcg gccgacagcggggctgaggccaccctgcaggctgaactcgctgagatccaagagaaatgg aagtcagcaagtgtgtgtctggaggagcagaagaaaaaactgtctggcttgctgcaggac tgggaaaaatgtgagaacggaatagctgattctctgaagaaactacgaactttcaaaaat aggctttcccagcctctcccagatcatcacgaagagctccacgcggagcagatgtgctgc aaggaattggaaaacgcagttgggagctggacagatgacttggcacagctgacactgctg aagaaggctctctgtgcttacatcagtgcagatgatatctccatccttaacgaacgcatg gagcttctgcagaggcagtgggaagaactatgccaccagctctccttaaggcgacagcaa gtaagtgagaggctgaacgagtgggccgtcttcagtgaaaagaacaaggagctttgcgaa tggctgactcagatggaaagcaaggtctctcagaatggagacattctcattgaagaaatg attgagaagctcaggaaggattatcaagaggaaattgcaattgcccaagagaacaaaata cagctccagcaaatgggagaacggctggctcgagccagccatgaaagcaaagcgtctgag attgagtacaagcttggcaagatcaatgaccggtggcagcaccttctggacctcatggca gccagggtaaagaagctgaaggagactctggttgcagtacaacagctggataagaacatg agcagtctgaggacgtggttagcccacatcgagtcagagctggccaaacccatcgtctac gattcctgtgactcagaagaaatacagaaaaagcttaacgagcagcaggagcttcagcga gacatcgagaaacacagcacaggcgtggcctctgtgctcaacctgtgcgaggtccttctc catgactgtgatgcctgcgctacagacgccgagtgcgattccatccagcaggctacgcga aacctggaccgccgatggaggaacatctgtgccatgtccatggaaaggaggctcaaaatt gaagagacatggcgattgtggcagaagtttctggatgacttttctcattttgaagattgg cttaagatctcagaaaggacagctgcctttcccagctcttccggggtgctctatacagtt gccaaggaggaactaaagaaattcgaggctttccagcgacaggtccatgagagcctgacc cagctggagctgatcaacaagcagtaccgccgcctggccagagagaaccgcacggacgcg gccggcagcctcaaacagatggttcacaaaggcaaccagagatgggacaacctacagaag cgtgtcacctccatcctgcgcagactcaagcatttcattggccagcgggaggagttcgag acggcacgggacagcattctggtgtggctgacggagatggatctgcagctcaccaacatc gagcacttctctgagtgtgacgttcaagctaaaataaagcagctcaaggccttccagcag gaaatctcattgaaccacagtaagattgaacagataatcgcccaaggagaacagctgata gaaaaaagtgagcccttggatgcggccgtcattgaggaagagctggatgagctccgacgt tactgtcaggaggtcttcggacgcgtggaaagataccataagaaactgattcgcctgcct ctcccagatgatgagcacgacctctctgaccgggagctggaactggatgaggctggagct ctgtcggacctccactggcgggacacctccacggacggcgtgctctccccgcagccttct tccaacccctccctctcactcgcccagcccctccggagcgagaggtctggacgagacacc cctgccagtgtggactccatccccctggaatgggaccatgactatgacctcagccgtgac ctggagtccgccgtgtccagaactctgccatctgaggatgaagagggtccggaagataaa gatttctacctcaggggagctgttggcttatcagatgtagtgatccctgaaagtcccgag gcctatgttaaactcacagaaagtgcaatcagaaattcctctggggaccctggtgccttg gagtcacagatccgacagctgggcaaagccttggatgacagccgctttcagatgcagcaa acagagaatatcatccacagcaaaacgcccacaggaccagagctagactccggctacagg ggctatatgaaacttctgggtgaatgcagtggcagcatagactcagtgaaaagactggag cacaagctgaccgaggaagaggaccattttcctggctttgttaacttgaatagcactgaa acccaaacagctggcgtgattgaccgctgggaactcatccaggcagaggccctgagcaag gagctgaggatgaaacagaagccccagaggaggcagcagttggactcagatctgaatagc gttctgacctggctgcaggagacggagggcgacctggaacagcttcagcgcctacagctc agcaccgacatccagtccatcgcgttccaaatccagaagctgaaggagctccagaaagct gtggaccagcgcaaagccatcatcctgtccatccatctgtgcagctccgagttcactcag cctggccgggaggagagccaggatcttcaggatcgcttgtcccagatgaacgggcggtgg gaacgcgtgtgctccctgctggaggagtggcggggtcttctccaggatgcgctcatgcag tgccaggattttcatgaaatgagtcacagtttgctgcttatgctggagaacattgacaga aggaaaaatgaaattgtccccattgattctaaccttgatgcagaaatacttcaggaccat cacaaacagcttaagcaaataaggcatgagctgttggaatctcaactcaaagtggcctca ctgcaagacatgtcttgccaactattggtgaatgctgaaggcacagactgtttagaagcc aaagaaaaagtccacgtgattggaaatcgactcaaacttctcttgaaggaggtcagtcgt catatcaaggagctggagaagttattagacatgtcaagcagtcagcaggatctgtcttcc tggtcttctgctgatgaactggacacctcaggatctgtgagtcctacctcgggaagaagt accccaaacagacagaaaacgccacgaggcaaatgtagtctctcacagcctggaccctct gtcaacagtccacatagcaggtccataaaaggtggctccgattcctccctttctgagcct cggccagcccggtccggccgagccttcctgttcagagtcctccgagcggctcttcctctt cagctcctcctgctgcttctcattgggctggcctgcctagtcccgatgtcagaggaagac tacagttgtgccctttccaacaattttgcccgatcattccaccccatgctcagatacacc aacggccctcctcctctctga

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