Bubalus bubalis (water buffalo): 102416069
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Entry
102416069 CDS
T05912
Symbol
GCLC
Name
(RefSeq) glutamate--cysteine ligase catalytic subunit isoform X3
KO
K11204
glutamate---cysteine ligase catalytic subunit [EC:
6.3.2.2
]
Organism
bbub
Bubalus bubalis (water buffalo)
Pathway
bbub00270
Cysteine and methionine metabolism
bbub00480
Glutathione metabolism
bbub01100
Metabolic pathways
bbub01240
Biosynthesis of cofactors
bbub04216
Ferroptosis
Module
bbub_M00118
Glutathione biosynthesis, glutamate => glutathione
Brite
KEGG Orthology (KO) [BR:
bbub00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
102416069 (GCLC)
09106 Metabolism of other amino acids
00480 Glutathione metabolism
102416069 (GCLC)
09140 Cellular Processes
09143 Cell growth and death
04216 Ferroptosis
102416069 (GCLC)
Enzymes [BR:
bbub01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.2 glutamate---cysteine ligase
102416069 (GCLC)
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Motif
Pfam:
GCS
HinfI
Motif
Other DBs
NCBI-GeneID:
102416069
NCBI-ProteinID:
XP_025127874
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Position
2:complement(44772186..44817401)
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AA seq
599 aa
AA seq
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MGLLSQGSPLSWEETQRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDH
EKKKAQLVLSGEELLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTV
EDNMRKRRKEATSLLGENQALCTITSFPRLGCPGFTLPEFKPNPVEGGASKSLFFPDEAI
NKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPAPFIETFPEDEEATTASKPDHIYMDA
MGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVPLKNNHYRISKSRYDSIDSYLSEC
GEKYNDIDLTKDKEIYEQLLQEGLDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFE
NIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDF
LIPLSKVDENMKVAQKRDAVLQELFYFRKDICKAGGNAVVDGCGKAAGRAEPAAEEYALM
TIDTIINGKEGVFPGLIPILNSYLESMEVDVDTRCSILNYLKLIKKRASGELMTVAKWMR
EFIAKHPDYKQDSVITDQMNYSLLLKCNQIANESCECPELLGPAFRKVRYSGSKTDSST
NT seq
1800 nt
NT seq
+upstream
nt +downstream
nt
atggggctgctgtcccagggctcgccgctgagctgggaggagacccagcgccacgccgac
cacgtgcggcggcacgggatcctccagttcctgcacatctaccacgccgtcaaggaccgg
cacaaggacgtgctcaagtggggcgatgaggtggagtacatgttggtgtcttttgatcat
gaaaagaaaaaagcccaactggtcctgtctggagaagaacttcttgaaactctgcaagaa
aagggggaaaggacgaaccccaaccatccgaccctttggagaccagaatatgggagctac
atgatcgaggggacacccgggcagccgtatggtgggaccatgtctgaattcaacacagtt
gaggacaacatgaggaaacggcgcaaagaagccacatctctcctgggggaaaaccaggcc
ctctgcacaatcacttcctttcccagattaggctgccctgggttcacgctgcccgagttc
aaacccaacccggtggaaggaggagcttccaagtcccttttctttcccgatgaagccatc
aacaagcacccgcgcttcagcacgctcaccaggaacatccggcaccggaggggcgagaaa
gtggtcatcaacgtgcccatctttaaggacaagaacaccccagctccatttatagagact
ttccctgaggacgaggaggccacgacagcctctaagcccgaccacatttacatggacgcc
atgggcttcgggatgggcaactgctgcctgcaggtaacgttccaagcctgcagcatatcc
gaggccagatacctttacgatcagttggctaccatctgcccaattgtcccactgaagaac
aaccactataggatcagtaagtcccgatacgattcgatagacagttacttatctgagtgc
ggtgagaaatacaatgacattgacctgacaaaagacaaagaaatctacgaacagctgttg
caggaaggcctcgaccacctgctggcccagcacgtggcgcatctcttcatcagagacccg
ctgactctgtttgaagagaaaatccacctggatgatgccaacgagtccgaccactttgag
aatattcagtccacaaattggcagacaatgcgattcaagcctcctcctccaaactctgac
attgggtggagagtggaattccggcccatggaggttcagctgacggactttgagaactcc
gcatatgtggttttcgtggtgctgctcaccagggtgatcctgtcctacaaactggacttt
ctcatcccgctgtccaaggttgatgagaacatgaaggttgcccagaagcgagacgccgtc
ctgcaggaactgttttatttcagaaaagacatttgcaaagcaggtggcaacgccgtggtg
gacggctgcggcaaggccgcgggcagggcggagccagcggccgaggagtacgcgctcatg
accatcgacaccatcatcaacggcaaggaaggcgtgttccctgggctgatccccatcctg
aactcctacctggagagcatggaggtggacgtggacaccaggtgcagcattctgaactac
ctgaagctcatcaagaagagggcgtccggagaattaatgacagttgccaaatggatgagg
gagtttatcgcaaagcatcccgactacaagcaggacagtgtaataactgaccagatgaac
tatagccttcttctaaagtgtaatcaaatcgcaaacgaatcatgtgagtgcccagagtta
ctcggaccagcgtttaggaaagtcaggtacagtggaagtaaaaccgactcttccacctag
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