Bufo bufo (common toad): 120982447 Help Entry 120982447         CDS       T07950                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism bbuf  Bufo bufo (common toad) Pathway bbuf04020   Calcium signaling pathway bbuf04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:bbuf00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     120982447 (RYR3)    04020 Calcium signaling pathway     120982447 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:bbuf04040]     120982447 (RYR3) Ion channels [BR:bbuf04040]  Voltage-gated cation channels   Ryanodine receptor    120982447 (RYR3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  120982447 NCBI-ProteinID:  XP_040268526 LinkDB All DBs Position 11:complement(48758223..49492534) Genome browser AA seq 4868 aa AA seqDB search MAEGGEVEDEIQFLRTDDEVVLQCVATIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVPP DLCICNFVLEQSLSVRALQEMLANTTANGQEGASQGGGHRTLLYGHAILLRHSFSGMYLT CLTTSRSLTDKLAFDVGLRDTATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSERY LHLSISNGMGNIQVDASFMQTLWNVHPTCSGSSVEEGYLLGGHVVRFFHGHDECLTIPST DSAEAQHRKVNYEAGGAGVRARSLWRVEPLRISWSGSHIRWGQTFRLRHITTGQYLALTE DQGLVLQDRAKSDTKSSAFCFRASKEKLDAGPKRDIDGMGAAEIKYGDSICFIQHVDSGL WLTYKSQDAKTARLGPLKRRAILHQEGHMDDGVTLQKCQHEESQAARIIRNTTGLFGQFI SDLDSLTGNNRTVTAPIALPIEEVVQTLQDLITYFQPPEEELEHEDKQNKLRSLKNRQNL FKEEGMLALVLNCIDRLNVYSTAAHFAEFMGEKSGPAWKEILNLLYELLAALIRGNRSNC AQFSNNLDWLISKLERLESSSGILEVLHCILIESPEALNLIEKGHIRSIISLLDKHGRNH KVLDVLCSLCVCNGVAVRTNQNLICDNLLPRRDLLLQTRLVNNVTSMRPNIFLGVAEGSA QYKKWYFEIIIDQVDPFLTPEPTHMRVGWASTSGYAPYPGGGEGWGGNGVGDDLFSYGFD GLHLWSGRVPRAVASSNQHLLASDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTEGLF FPVVSFSAGVKVRFLLGGRHGEFKFLPPAGYAPCYEALLPKEKMRVEPVKEYKRDYEGVR DLLGTTQFLSQASFIPCPIDTSQIVLPPHLEKIRDKLAENIHELWGMNKIELGWIYGKVR DDNKRQHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCLIVHSNQTAEENLKKVKLPK NYMMSNGYKPAPLDLSDVKLLPAQEVLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKR NPRLVPYALLDERTKKSNRDSLREAVRTFIGYGYNIEPPDQEITDQMMERVGIDKIRFFR LEQTYAVKSGKWYFEFEVVTGGDMRVGWARPSCRPDIELGADDRAFVFEGSRGQCWNMGS SFFGRNWQPGDVVGSMINLEDKSMIFTLNGELLITNQGSELAFADFEIENGFVPVCSLGL SQIGRLNFGKDASTFKYYTMCGLQEGFQPFAVNMNRDVAMWFSKRLPTFVNVPKNHPHIE VTRKDGTVEAPPCLKVTHKTFGTQNSNEDMIYCRLSMPVEFHSAFSNEENFQKRNALQEV SHTTTLYYYSVRIFAGQDPSSVWVGWVTPDYHVYSKHFDLSKNCTVTVTLGDERGRVHES VKRSNCYMVWGGDLSTGSQRSGRSNVDTDIGCLIDLATGLVSFTANGKDLGTCYQVEPNT KLFPAVFLQPTSTNLFQFELGKLKNTMPLSAAIFKSEEKNHVPQCPPRLDVQTITPVLWS RMPNNFLKVETERVSERHGWVVQCLEPLQMMALHIPEESRCIDILELSEQEDLMKFHSHT LKLYCAVCALGNNRVAHALCSHVDQSQLLYTIDNQYLPGLLRSGFYNLLISIYLESAKEG KLTMNNEFIIPITDDTRQIELFPDESKRHGLPGVGYSTCLRSDLHFTVPCFILTGEDRQQ HGPEIPIDILKTKAISMLTEAVQSSGDHIRDPVGGKVEFQFVPVLKLIATLLIMGVFEDE DVRQILLLIDPNVFGDHKEEDGEDSCEKEEVAQDEEKAVEAGEKATREAKAPVKGLLQTR LPESVKLQMCELLHYFCDCELKHRVESIVSFSDNFVSKLQCNQKFRYNELMQALNMSAAL TAKKTREFRSPPQEQINMLLNFQLHEDSPCPEEIRDELYEFHEDLLMHCGIPLEEEEEEE DDASWTGRLRSLVCKIKGRPKTEEQDPAEVEEKSPTTLKELISQTMVRWAQEDHIQDPEL VRIMFSLLRRQYDSIGELLQAMRKTYTISAASVEDTINLLASLGQIRSLLSVRMGKEEEM LMIDGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGGDKSQQITFPKMVASCCRFL CYFCRISRQNQKAMFEHLGYLLENSSVGLASPSMRGSTPLDVAAASVMDNNELALALQEP DLEKVVTYLAGCGLQSCPMLIAKGYPDIGWNPIEGERYLSFLRFAVFVNCESVEENASVV VKLLIRRPECFGPSLRGEGGNGLLAAMQEAINISENPALDLPSQGYQREVVEEDEEEEEI VHMGNAIMSFYSALIDLLGRCAPEPHLIQAGKGEAIRIRSILRSLVPTEDLVGIISIPLK LPAFNKDGTVFEPDMAASFCPDHKAPMVLFLDRVYGIKDQSFLLHLLEVAFLPDLRASAS LDTASLSVTEMALALNRYICSAVLPLLTRCAPLFSGTEHYAALIDSTLHTIYRLSKGRSL TKAQRDTIEECLLSICHHMRPSMLQQLLRRLVFDVPLLNEYCKMPLKLLTNHYELSWKYY CLPSGWGSFGLASEEELHLTEKLFWGIFDSLSHKKYEAELFRMSLPCLSAIAGALPPDYV DTRIKATPEKQMSVDTEGNFDPKPINTVHLTLPEKLEYIVNKNAEHLHDKWAYDKLHSGW KYGASLDENTKTHPLLRPFKTLSEKEKEIYRWPVRESVKTMLAMGWSVERTKEGEALALH RENEKMRSISQTNQGNGYSPTPIDLSNVVLSRELQGMVEMMAENYHNIWAKKKKMELEAK SAGSHPLLVPYDTLTAKEKGRDREKAQELFKFLQVNGYAISRGLKDMELDASSMEKRFAF KFLKKVLHYVDSAQEFIAHLEAVLGSGKSEKSPHEQEIKFFAKVLLPLVDQYFKNHCLYF LSSPIKTLSSSGYASNKEKEMVANLFCKLAALVRHRISLFGSDSATMVSCLHILAQTLDT RTVMKSGSELVKAGVRAFFENAAEDLEKTLENLKLGKFTHSRTQMKGVSQNINYTTVALL PILTSIFEHVARHQFGVDLLLDDVQVSCYRILCSLYSLGTGKKTSMKSQRTSLGECLAAL AGAIPVAFLEPSLNHNNPLSVFNTKSPRERAILGMPDTVEEMCPEMPHLEGLMKEINDLA ESGARYTEMPHVIEVVLPMLCNYLSYWWERGTENIPENTRPCCTQVTSEHLSVILGNILK IINNNLGIDEASWMKRIAVYAQPIISKAQPDLLKSHFIPTLEKLKKKAIKIVQEEELMKA DSKADTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKKPDIDSDELFRMVAEV FILWCKSHNFKREEQNFVIQNEINNLAFLTGNNKSKMSKPIQVKSGGQDQERKRTKRRGD LYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYSLRDTDDEVKEQLRNNLHLQE KSEDPAVKWQLNLYKDILKSEDGDSEKTVERVQKISAAVFHLEQVEQPLRSKKAVWHKLL SKQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQKLWIETEENSFEEKLIQDLANPKKNE EEEEEETEKKPDPLHQIILHFSRNALTERSKLEDDPLYTAYAAMMAKSCQNEEEDEEKEK TFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGISVLNGGNTV VQQKMLDYLKEKKDAGFFQSLSGLMMSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRERG EKVLQNDEFTRDLFRFLQLLCEGHNNDFQNFLRTQMGNTTTVNIIISTVDYLLRLQESIS DFYWYYSGKEVIDESGQHNFSKSLAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVG FLHVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVES SSNVEMILKFFDMFLKLKDLTSSDAFKEYDPEGKGIISKKEFQKAMEGQKQYAQSEIEFL LSCAEADENDMFNYVEFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLQCLLDPANSVL NYFSPYLGRIEIMGGAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQEKM ELFVNFCEDTIFEMQLASQISESDAADRPEEEEEEEPHHMIEVGEEDEEEKSLESSSAFI VACTALRKNMSNFFKMLTLKNIGKQFRKVKKMTLKELVKVFFSFFWTLFVGLFQFVFTIV WGIFQILWGTVFGGGLVEGAKNIKVTKILGDMPDPTQFGIHDDVLEAEKADSPENASSTE LAHLVKGDKGDLDMPDIFGMHTKKEGSKHGTEIGLGDFSEIASSENANSLESAVHKKKKA LAAEIAKENEDNSKAESEKADMEDGEKKDKAKAEEQSEFLESKEGPKRRRRRGQKKEEPE AFMANFLAGLEINQTKMLNYLARNFYNLRFLALFVAFAINFILLFYKVTEEPASTEDTDH DSNIWNTYQEDEEDAEEGAVYFVLQENTGYMAPTLRILAIIHTIISFLCVIGYYCLKVPL VVFKREKEIARNVEFDGLYITEQPSDDDIKGQWDRLVINTPSFPNNYWDKFVKRKVINKY GDLYGADRIAELLGLDKNALDFSPVEKTKTEEGSLVSWLSSIDMKYHIWKLGVVFTDNSF LYLAWYTTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVY LYTVVAFNFFRKFYNKSEDEDDPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPY EMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYFD TTPHGFETHTLQEHNLANYLFFLMYIINKDETEHTGQESYVWKMYQERCWDFFPAGDCFR KQYEDLLG NT seq 14607 nt NT seq  +upstreamnt  +downstreamnt atggctgaagggggcgaagtggaggacgagatacaattcctccgcaccgatgatgaagtt gtccttcagtgtgtcgccaccatccataaggagcagaggaagttctgtttggcagctgag ggacttgggaatcgactttgctttctggaaccaacttcagaagccaaatatgttcctcct gacctttgcatatgtaattttgtgctggagcagtccctttctgtcagggcccttcaagaa atgctggcaaacacaacggcaaatggccaagaaggggcatcgcaaggcggtgggcataga acgttactgtatggccatgcaatcttactgcgacattcattcagtggtatgtacttgacg tgtcttactacgtccagatcccttacagataaacttgcttttgatgttgggctgcgagat acggcaacaggagaggcttgttggtggacaatacatcctgcatccaagcaaagatcggaa ggagagaaagttcgtattggggatgacctgattttagtcagtgtgtcttctgaaagatat ctacatctatccatatccaatggaatgggcaacatccaggtggatgcctctttcatgcag accctgtggaacgtccatccgacatgctctgggagcagtgtggaagaaggatatcttctc ggtggacatgtggtccggtttttccatggccatgatgaatgtttgacaatcccatctact gactcagcagaagctcagcataggaaagttaattatgaggcaggaggggcaggtgtccgt gccaggtcattatggagggtggaacccctaagaataagttggagtggaagtcacatcaga tgggggcagacattccgcctacggcatattacaaccgggcaatatttggcactgacagag gaccaaggattagtactacaagaccgagcaaagtctgataccaagtcttcagcattctgt ttcagagcatcgaaggaaaagttagacgctggcccaaagcgagacattgatgggatggga gctgcagagattaagtatggggattccatctgctttattcagcatgtagacagtggcctg tggctgacctacaaatctcaagatgccaagacagcacgactgggacctctaaaaagaagg gcaatcctgcaccaagaaggccatatggatgatggtgtcacattacagaagtgtcagcat gaagagtcccaagctgctagaatcattcggaacaccacaggcctgtttggccagttcatc agtgacctggattctctgacggggaacaaccggactgtgacagcccccatcgccctgcct attgaggaggtagttcaaaccctgcaagacttgatcacttatttccagcctcccgaggaa gaactagaacatgaagacaaacaaaataaactccgctcactcaaaaacaggcagaaccta ttcaaagaggagggaatgctggctctggtgctgaactgtattgaccgtctgaatgtatac agcactgcagcacactttgctgaatttatgggggagaaatctggaccagcatggaaggaa atcctgaaccttctctatgaattactagctgctctaattcgcggaaatagaagcaactgt gcacaattttccaataatttggattggcttattagtaaattggagcgccttgaatcatct tcaggaatactggaggttctacattgcatcttgattgaaagccctgaggctttaaattta atagagaagggacacatacgctctataatttctcttttggacaaacatggacgaaaccac aaggttctggatgtcctgtgctctctttgtgtatgtaatggggttgcagtacgtacaaac cagaatctaatttgtgacaacctgctccccaggagagatttgttgttgcaaactcgttta gttaataatgtcaccagcatgaggccaaatatcttcctgggtgtagctgagggttcagcg caatacaagaagtggtactttgagattattatagatcaggttgatccatttctaactcca gagccaactcacatgcgtgtaggttgggcttccacctctggttatgctccttatcctggt ggaggtgaaggatggggaggcaacggtgtaggtgatgatcttttctcctatggctttgat ggtctccatttatggtctggacgggtaccgagggccgtggcttcaagtaaccagcattta ttagcatctgacgacgtggtcagctgttgcctggatttgggggtgcctagtatttctttt cgtattaatggacagccagtccaaggcatgtttgagaacttcaacaccgaaggtctcttt ttcccagtcgtaagcttttctgctggagtaaaggttcgatttcttcttggtggtcgacat ggggaattcaagttcttacccccagctggctatgctccatgctatgaggccctgttgcca aaagagaagatgagagtggagcctgtaaaagagtacaagagagactatgaaggagttcgg gatttgttgggtacaacacaatttctgtcccaagcgtcattcatcccttgtcccattgat accagccagattgttttaccccctcatcttgagaagatccgagacaaattagcagaaaac atccatgaactttggggtatgaataaaattgagcttggttggatctacggcaaggtgcga gatgataataaacgtcagcatccttgtttggtagaattttctaagcttccagaaactgaa aagaattataacctgcaaatgtccactgagactttaaagactttgctggctcttggatgt ctcattgttcattcaaatcaaactgctgaagaaaatctgaaaaaagttaaactcccaaaa aactatatgatgtccaatggctacaagcctgcccctttggacctatctgatgtaaaactg ttaccagcccaagaagttctagttgataaacttgccgagaatgcacacaatgtctgggca aaagatagaatcaaacaaggatggacctatggcattcaacaggatctgaagaataaacga aatcctcgtttggtgccatatgctttacttgatgagcgaactaagaaatctaatagagac agtttacgagaagctgtcagaacatttattggatatggctataatatcgagccaccagac caagaaatcactgaccaaatgatggaacgagtcggcatagataagatacgcttctttagg ttggaacagacctatgctgtgaagtcaggaaagtggtattttgagtttgaggtggtgacc ggaggtgatatgcgtgtaggctgggccaggcccagttgtagacctgacattgaacttgga gcagacgatcgggcatttgtatttgagggaagcagaggacagtgttggaacatgggaagc tcattctttggtcgaaactggcagcccggagatgttgtaggatccatgattaacttggaa gataaatcaatgattttcacgttaaatggagaacttctaatcacaaatcaggggtcagag ctagcatttgctgactttgaaatagagaatggttttgtccctgtctgctcccttgggttg tctcagattggtcgcttgaattttggtaaagatgccagcacgttcaaatactacacaatg tgcggcctacaggagggcttccaaccgtttgctgtcaacatgaacagagatgtagccatg tggttcagtaagcgcttaccaacctttgtcaacgtgccaaaaaatcatcctcacattgag gtgacaaggaaagatggaactgtagaagcccctccatgcttaaaggtgacacataaaacc tttggcacccagaatagcaatgaagatatgatatactgcaggctgagtatgcctgtggag ttccactccgccttcagcaatgaggagaacttccagaagagaaacgcccttcaagaagtt tctcacacaactacattgtattactactctgtccggatatttgctggacaagacccgtca tcagtatgggtaggatgggtgactcccgactaccacgtctatagtaaacattttgactta agcaagaactgcactgtgactgtcactttaggagatgagaggggcagagtgcatgaaagt gttaaacgaagcaattgttacatggtttggggaggtgacctctctactggctcacagcgg tcgggccgcagcaatgtagatactgatattgggtgccttattgatctggccacaggactt gtctccttcacagccaatggaaaagatctggggacctgctaccaggttgaaccaaacacc aagctgttcccagcagtttttctgcagccaacgagcactaatctcttccagtttgagctt gggaaattaaagaacaccatgccactttcagctgctatatttaaaagtgaagagaaaaac catgtgccccagtgcccccctcgtttggatgtacagactatcacacccgttctctggagc cgtatgccaaataatttcctaaaggtagaaacagaacgtgtcagtgagcgtcatggctgg gtggtgcagtgcttggaacccttgcagatgatggcattgcatatacctgaggagagcagg tgtatcgacatcttagaactttccgagcaggaagacctcatgaaatttcactctcacacc ctgaagttgtattgtgctgtttgtgctctgggcaacaatcgtgtcgcccatgccttgtgc agccacgtggatcaatcccaacttctatatactattgataaccaatacctacctggcctt ttaagatcaggtttttataaccttcttatcagtatctacctggagtctgccaaggaggga aagctgacgatgaacaatgagtttataataccaatcactgatgatacaaggcaaatcgaa ctgtttcctgatgaatcaaaaaggcatggtttacctggggtcggttatagtacctgcctg agatctgaccttcacttcacagtaccttgctttatattgactggagaagaccgccagcaa catggtccagagattcctattgacattctcaaaaccaaagcaattagcatgctgaccgag gcagtgcaaagcagtggagaccacatccgagatcctgtggggggcaaagtagagttccag tttgtgccagtgctaaagctcattgccactcttcttataatgggagtttttgaggatgag gatgtccgtcaaattctgctgcttattgatcctaatgtttttggtgaccacaaagaagag gatggagaagacagctgtgagaaggaggaagtggcacaagatgaggaaaaagctgtggag gctggagagaaagcaacaagagaagctaaggcccctgtgaaaggtcttctgcagactcga ctaccggaatctgtcaaacttcagatgtgcgagctacttcattacttctgtgactgtgag ctgaagcatcgtgtggagtccattgtctccttctctgataactttgtgtcgaagcttcag tgcaatcagaagttccgctacaatgaattgatgcaagcactgaacatgtctgctgccctg acggccaagaaaaccagggagttccgctctcctccacaggaacagattaacatgcttctg aatttccaactacatgaagacagtccttgtcctgaagagatacgggatgaattatatgag ttccacgaagacctcctaatgcactgtggcattccactcgaagaggaagaagaggaagag gatgatgcatcatggacaggtcgtcttcgatcacttgtgtgcaagatcaaagggcggcca aagactgaagagcaggatccagcagaagtggaggagaaatcgcctaccacacttaaagaa ctcatctcacaaactatggtgagatgggctcaagaggaccacattcaagatcctgagctt gtgcgtataatgttcagcctcctgcgccggcaatacgacagcattggagagttgttacag gccatgaggaaaacctacacaatcagcgcagcctctgtggaagatactataaaccttttg gcctctctgggacagatacgctcactgttgagtgtgagaatgggcaaagaagaggagatg ctcatgattgatggattgggtgatatcatgaacaacaaagtcttctatcagcatcctaac ttaatgcgagttctaggcatgcatgaaactgttatggaagtcatggtaaatgtactggga ggagacaaatctcagcaaattactttccccaagatggtggcgagttgctgcaggtttctc tgctatttctgcagaattagtcggcaaaatcaaaaggccatgtttgagcatcttggctac ttgctggagaacagcagtgttggtctggcatctccgtctatgagaggctctacacctcta gatgtcgctgccgcctctgtgatggataacaacgaacttgctttggcgttgcaggaacca gatttggagaaggttgtgacatacttggcaggttgtgggctgcagagttgtccaatgtta attgccaaaggatacccagacattggatggaatcccattgagggcgaacgctacctctca ttcctgcggtttgcagtctttgtgaactgcgagagtgttgaagaaaacgccagtgtggtg gtgaagcttctcatccgacgcccagagtgttttggaccttccctgagaggagagggggga aatggtttgctggcggcaatgcaggaggctattaacatctctgaaaacccagctctggac ctgccttctcaggggtatcagagggaagtggtcgaggaagatgaagaagaagaagagatt gtacacatgggaaatgctataatgtccttttattctgccctgattgaccttctgggacgc tgtgcaccagaaccacatctgatccaagctggtaaaggtgaagctatacgaattcgctcc atcctccgatccttggtgcccacagaagatcttgttgggattattagcatcccattaaaa ctgcccgcatttaacaaagatggcacagtatttgaaccggatatggcagccagcttctgc cctgatcacaaagcccctatggtacttttcctggaccgtgtctatggtattaaggaccaa agcttcctccttcatttactggaggtggccttcttacctgatctgagagcatcagcatct ctcgacacagcttccctgagtgtcacagagatggctcttgccttgaatcgatatatttgc tcagcggtactcccattgctcacccgctgtgctcctctcttttcgggcaccgagcactat gcagcattaattgattctaccctgcatacaatatatagactgtccaaggggcgttctcta accaaagctcagagagacaccattgaagaatgtctgctttcaatatgccatcatatgcgg ccttccatgcttcagcagctcctgcggcgtctggtttttgatgtcccattgctcaacgaa tactgtaaaatgcctctgaagctcctgacaaaccattatgagctgagctggaaatattac tgccttccttctggatgggggagctttggtttggcctcagaggaggaattgcacttgaca gagaagctgttctgggggatttttgactccctttctcataagaagtatgaggctgagctc ttcagaatgtccttgccatgtctcagtgcaatcgctggtgctttgcctcctgattatgtt gacacaagaattaaagcaacacctgagaagcagatgtcagtagacaccgaaggaaatttt gacccaaagcccatcaatacagttcatctgacattacctgagaagctggaatatattgtc aataagaacgccgagcacttacatgataaatgggcctatgacaagctacatagtggttgg aagtatggagcatcacttgatgaaaatactaagacacatcctctactgagacccttcaag actctgtctgaaaaggagaaagaaatttaccgctggccagtaagggagtctgtgaaaact atgttggcaatgggatggagcgtggaaaggactaaagaaggagaagctttagcacttcat cgtgaaaatgaaaagatgcgcagcatttcccagactaaccagggaaatggttatagtccc acaccaattgatctgagcaatgttgtcctttccagagagctccagggaatggtagaaatg atggcagaaaactaccacaacatttgggctaagaagaagaagatggagctggaagctaaa agtgcaggcagtcaccccctattggtgccttatgacacattaacagcaaaagaaaaaggt cgggatcgtgagaaagctcaagaactcttcaaattcttacaagtaaatggttatgctata tccaggggattaaaagatatggaactagatgcatcttctatggagaaaagatttgccttt aaatttctgaagaaagtcctacattatgtagattcggcgcaggaatttattgcacattta gaagctgttttgggcagtggtaaatcagagaagtcgccacatgagcaggaaatcaaattt tttgctaaagttctcttacctctcgttgaccagtactttaagaatcactgtctgtacttt ctgtcctccccaatcaaaactctgagcagtagcggttatgcatctaacaaagagaaagag atggtggcaaatctgttctgcaaactggcagctcttgtaagacataggatatcactgttt ggaagtgactctgccaccatggtgagctgtctgcacattctggctcagacactcgacaca cgcacagtgatgaagtctggttctgagttggtaaaagctggagttagagctttctttgaa aatgctgctgaagatttagaaaagaccttggaaaacttaaagcttggaaaattcactcat tcaagaactcagatgaagggtgtctcccagaacattaactacaccacagtggctctcctt ccaatcctgacctccatttttgaacatgtggcacgtcaccagtttggtgtggatttgcta ttggatgacgttcaagtttcctgttaccggatcctctgcagtctgtactcccttgggaca ggaaagaaaacatctatgaagtcgcagcggaccagccttggagaatgtctggcagcgctg gccggagccatacctgtagcttttcttgagccatcactaaaccacaacaaccctctctca gtttttaacaccaaatcacctagagagagagccattctaggtatgccagacacagttgaa gagatgtgtccagaaatgcctcatttggaaggtttaatgaaggaaattaatgatctggct gagtctggagccaggtatacggagatgccacatgttattgaagtggtgctgccaatgtta tgcaactatctttcctactggtgggagcggggaacagaaaatataccggaaaacaccagg ccgtgctgtactcaagtgacttcagaacatctaagtgtcatcttgggcaacatcctgaaa ataattaacaacaatctgggaatagatgaagcttcctggatgaagagaattgcagtgtat gctcagccaattatcagcaaggctcagccggacctcctgaagagccatttcatccccacg ctggagaaattgaagaaaaaagcaataaagattgtgcaagaggaggagctgatgaaggca gacagcaaggctgacacccaggaggcagagctgctgattctggatgagtttgccgtgtta tgcagagatctctatgccttctacccaatgttgatccgatatgtagataacaacagatct aattggctcaaaaaaccagatatagactctgatgagctgttcagaatggtggctgaagtg ttcattctttggtgcaaatcacataactttaagagagaagaacagaattttgtgattcaa aatgaaatcaacaatctggcatttctaactggaaacaacaagagtaagatgtcaaaaccc atacaagtaaagtctggagggcaagatcaggagcggaagagaaccaagcgcagaggggac ctttactccatacagacttccctcattgtagctgccctgaagaagatgttacccattggt ctgaacatgtgcacaccgggggaccaggaactgatctcactggcaaagagcagatacagt cttagagatacagatgacgaagttaaagaacagctgcgcaataatcttcatttgcaggag aaatccgaagaccctgcagtgaaatggcagctcaatctctacaaggatatactgaaaagt gaggacggggattctgagaaaactgtggaacgtgtgcagaaaatctctgcagcagtcttc catcttgagcaggtggagcagcccttgaggtctaagaaggctgtgtggcacaagctgctg tcgaaacagaggaaaagggctgtggtggcgtgctttcgcatggctcctttgtataatctg ccaaggcaccgttctattaacctcttcctccatggttatcagaaattatggatagaaaca gaggaaaattcctttgaggagaaactaattcaagatttggctaatcctaagaagaatgaa gaagaggaagaggaggagactgagaaaaagcctgatcctcttcatcagattattttacac ttcagtcgcaatgccctcactgagaggagcaagcttgaggatgaccccttgtatacagca tatgcagctatgatggctaagagctgccaaaatgaagaggaagatgaggaaaaagagaag acatttgaggagaaagaaatggaaaagcaaaagaccttgtatcagcaggcccgtctacat gaaaggggggctgctgagatggttttgcagatgatcagtgcaagtaaaggtgaaatgagc cctatggttgtagagacactgaagcttggaatatcagttctgaatggtggaaatactgtt gtgcagcagaaaatgttagattacctaaaagaaaaaaaggatgctggatttttccagagc ttgtccggcttaatgatgtcatgcagcgttcttgatttgaatgcatttgaaagacagaac aaagcagaaggccttggaatggtcacagaagaaggaacattaattgtccgggaacgaggt gaaaaagttttacagaatgatgaatttacaagagacctcttcaggttcctgcagcttcta tgtgaaggacacaacaacgactttcagaacttcctgaggactcaaatggggaatacgaca acagtgaatattatcattagcacggtggattaccttctacgcctgcaggaatctatcagt gacttctactggtactactcagggaaggaggtgattgatgaatctgggcagcacaacttt tcaaagtctcttgctgtgaccaaacaaatatttaattcgctcacagaatacattcagggt ccctgcataggtaaccagcagagtttggcacacagcaggctgtgggatgcagtggttggt ttcctccatgtttttgcaaacatgcagatgaagctgtcacaggattccagtcagattgaa ctccttaaagaacttcttgatcttcttcaagacatggtggtgatgctgctttcccttcta gaagggaatgtcgtgaatgggactattggaaaacaaatggttgacactcttgtggagtca tctagtaatgttgaaatgatactgaagttcttcgatatgttcctcaagttgaaagatcta accagctctgatgcttttaaggaatatgaccctgaaggaaagggtataatttcaaaaaaa gaattccaaaaagccatggaggggcaaaaacaatatgctcaatcagaaattgaatttctt ctctcctgtgcagaagcggatgaaaatgatatgtttaactatgtagagtttgtagaccga ttccatgaaccagctaaagacattggattcaatgtggctgtcttgttgaccaatctctca gagcacatgccaaatgactctcggctccaatgtttgctagaccctgcaaacagtgttctg aattacttttctccatacttgggacgtattgagataatgggtggagcaaaacgaatagag agagtgtattttgagatcagtgaatcaagccgaacacagtgggagaaaccacaggtcaag gagtccaaaagacaatttatatttgatgtggtcaatgaaggtggggaacaggaaaaaatg gaactatttgttaatttctgtgaggatacaatttttgagatgcagttggcatctcagatt tccgagtcagatgcagctgacagacctgaagaagaggaagaagaggaacctcaccatatg attgaagttggtgaagaggatgaagaggagaagtctctagaatcatcatctgcttttatt gttgcatgtacagcacttaggaaaaatatgtccaacttcttcaagatgttaaccttaaag aacattggtaaacagtttcggaaagtgaaaaagatgactctcaaagaattagtcaaagtc ttcttttcttttttttggacactgttcgttggtttattccaatttgtgtttacaatagta tggggaatatttcagattctttggggcacagtgtttggaggtggcttagttgaaggggcc aagaatattaaagtaaccaaaatattaggagatatgcctgatcccacacaatttggaatc cacgacgatgtcttggaagctgaaaaagcagattcacctgaaaatgcctcatctacagag cttgcacatcttgttaaaggagacaaaggagatttggatatgcccgatatttttggcatg cacacaaaaaaagaaggctctaagcatggcacagaaattggtcttggtgatttctcagaa attgcaagttcagagaatgcaaacagtttggagagtgctgtacataagaagaaaaaagct cttgcagcggaaatcgctaaagaaaatgaggacaactcaaaagcagaatccgagaaggct gacatggaagatggtgaaaaaaaggataaagctaaagctgaagaacagtctgaatttttg gaaagtaaagaggggccaaagaggaggaggagacgaggccagaagaaagaggagcctgaa gcatttatggctaatttcttggcaggactggagattaatcagaccaaaatgctgaattac ctggccagaaatttctacaatctacgattcctcgctctgtttgtggcatttgccattaac tttattctattgttctacaaggtcacagaggaacccgcctcaactgaagacactgatcat gattccaacatatggaacacgtaccaagaagatgaggaagacgcagaagaaggagctgtt tattttgtcctgcaagaaaacacaggctatatggctccaacattacgcatcttggctatt attcacaccatcatctctttcctctgtgttattggatactactgtcttaaggttcctctt gtggtatttaaacgagagaaggaaattgctcgcaatgtggagtttgacggtctgtatatt acagagcaaccctcagatgatgacatcaaagggcagtgggatcgtcttgttataaatact ccgtcttttcctaataattactgggataaatttgttaagaggaaggttatcaataaatat ggagacttatatggagctgacagaattgctgaactcctgggacttgacaaaaatgccttg gacttcagcccagtggaaaagaccaaaacagaagagggatcccttgtatcatggttgagt tccattgatatgaagtatcacatctggaagcttggagtggtatttactgacaactccttc ctttacctcgcttggtacactaccatgtcaattcttggacattataacaattttttcttt gccgctcacctcctggatattgcaatgggctttaagacactgcggacaattctatcatcg gtgacccacaatggaaaacaattggtgttaactgttggtctcctggcggttgttgtctat ctttatacggttgtggctttcaactttttccgaaagttttacaacaagagtgaggatgaa gatgatccggatatgaagtgtgatgatatgatgacgtgttatctgttccacatgtatgtg ggggtgagagctggaggtggcattggagatgagattgaggaccctgccggtgacccttat gagatgtatcgcattgtgtttgacatcaccttcttcttctttgttattgtcattctcctt gccattattcaaggtttgatcattgatgcttttggagaactgagagatcaacaagaacaa gtcagagaagatatggagacaaaatgcttcatttgtgggattggaaatgattactttgat acaacgccgcatggctttgaaacacatactttacaagaacacaacctggctaactatttg ttcttccttatgtatatcattaataaggatgagacagaacacactggacaggaatcttat gtctggaagatgtatcaagagaggtgttgggacttcttcccagctggtgactgtttccgc aagcaatatgaagacctgcttggataa

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