Bufo bufo (common toad): 120998709 Help Entry 120998709         CDS       T07950                                  Symbol SYNE1 Name (RefSeq) nesprin-1 isoform X1   KO K19326   nesprin-1 Organism bbuf  Bufo bufo (common toad) Pathway bbuf04820   Cytoskeleton in muscle cells Brite KEGG Orthology (KO) [BR:bbuf00001]  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     120998709 (SYNE1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:bbuf03036]     120998709 (SYNE1) Chromosome and associated proteins [BR:bbuf03036]  Eukaryotic type   Centrosome formation proteins    LINC complex     120998709 (SYNE1) SSDB OrthologParalogGFIT Motif Pfam:  Spectrin Spectrin_SYNE1 CH SYNE1 KASH SYNE3 Spectrin_SYNE1_2 SR_desmoplakin_3 Motif Other DBs NCBI-GeneID:  120998709 NCBI-ProteinID:  XP_040285428 LinkDB All DBs Position 4:472953116..473366244 Genome browser AA seq 8827 aa AA seqDB search MSWCKEVGTRKVSSINLVPGFFQYLRDEQEAVQKRTFTKWINSHLAKRNPPLIINDLFED IKDGKNLLALLEVLSGQKLPCEQGKHLKRIHWVANIGAALKFLEGRRIKLVNINSTDIVD GRPSIVLGLIWTIILYFQIEELTSNLPQLHSLSSSTSSVDSVVSSETASPPTKRKVVTKI QGSAKKALLRWVQYTAGKRLGIEIKDFGPSWRNGIAFHSMIHAIRPELVDMDKLKGRTNH ENLEEAFSIAETELGIPRLLDPEDVDVDKPDEKSIMTYIAQFLKHYPDPHNSSADGQGDE REDRLVLRDLKVWIEQFERDVTRAQVVESSLQDRYQSYKTYRVQYEMKRKQIESSIQPLG KDGKLSLDQTMVKQAWDKVSARIFDWHVQLDKSLPAPLGTIGSWLYRAEVALREDIIMQQ SHEETANMIHRKLEQHKDVLKNLDGYKKAFQEIHRSGSVNGVPVPVEQLEDMAERFSFVA SSSQLHMMKLEFMELKYRLLALLVLAESKLKSWIIKYGRRESVELLLQNYITFIDGNRFF DQYEFTSQSLKQAAEMYVKADGSAEEAEVVTKFLNETTIQWRNLSVEVRSVRSMLEEVIN NWEKYSNTVGSLQAWLEDAEKMLDQPEHAKKEFFRHLPHMIQQHTTMNDSGNFLIETCDD TVSKDIKQQLLLLNGRWRELFVEVKHYARADEFERARKEYADGLIALAAFAEGGNERISI PLEVSFLNVKMFVQDLEDIKQKMPVIEAQYKSVTRMAQLLTKESPQSESSEMLAAVSRIK DQLNKIRERYPPLLYESQQLLAPLGDFENQMTNFYECLEKLSEIISLSDLDLQSTSVLKQ KQRELLMYQESCKKALVVIEKNGQAVHKALTISKSLHHFDRSCLQKKITDAQSAFQNMAK KIPEWQKKVEFNNSMMKKFEESRRELEKVLKTAESYFKEKGNPEELLKKHTDFFGQLDLK VLNTFLKACDELTDILPEQDQQPLQETVRKLHKQWKDFQGEAPYHLLRLKIQLEKNRING TIEECRAELTRENKVLPVDGSEKVIKEHRAFFGEKGCYQLCEKRLRLIEELCLKLQERDP VKGVYESSRELLKDLKAQIDGTHLKLMENPDKWKDFGIRLTRITDWLVAKDRQLKQIKNE VTEASKYEQVKTSVQNIRRDARKQEDELGYLKDRLSALTVVAVETEIKKQGSNLSRASAD LKVLLDSLSEADKILSNVGDCVQYKTEVKNVLSEILTSSKDVLSEAEKILDTESFEEAQE MLFHYEEKIKKIQSKKQDVQVQIAQAKQLQTTQGLSKDIEEDFTKMETELDKVETTMIKQ KESLKDTIHNWEQIETSKKSIVQDLKHMESTLERPLNFETLESLSSELQQAKEVGKRMED LSVQAENLVEKSSDIQLGNNSKRHLQEKTRSVQDNVKHVKETLTENIRKTEMAKDTWQRF DRDFAAHSTWISEREKELSDLERSDISAELQVTRIQEILKEMQNKSNAVKELEAQSQAFT EFISSAEMARIKAKLSQMAKHSDGLKENAHQLEGNILGIAKQQQKFDDTIRQIQTSLENI EASLALPVHNCSSAAETYKVLHSHQDLCHDVEMLKNNIHSLSAGTRKLTNKSTVMQAISN LQTRFEVVNTKAKERLSLLEQLLVHWQRQEKEISSFVTWLETSEALAGPQQGHFSADKAK LESEMHSLQDLKEELTTQSQRYTVLVQLCASLYPTSSESSVEQLREHLEKLSQRWNILPE AVLKRIGVMETIIGEHQKFDDLLLEFSLWIQQFLKDLQDAAEINTSDYESTLLLNKDHIA KVKTQQKEIDHLKDQLSKLCAFTIPGDHSVLEGRVTDCVQLFEETVQITGRRQESLSKVG SFLQMYQQSLNVLCNLKETVEGASSLDKDKSESLEKDIHRLAQEIDELTALAVGLDTALT KAQYHLKSSISEERTSCRALADNLIMELEKVQKFLGTKLCEAEALGALWKSFLDCKEKLL KTIEDIEEKADGEEMKESTLPALQQRLKMFNELEEEINSYQHEKQWLMDKAKQIAQKDLS MAAEADKELNGLIMTWEDTHKLISESQEQCLLLINLMKEYEHLRSSITRLIENAENMITI KSTLKDQEDIRRSIAKHESAKNELNENQRELDDFTNKGKHLLVELKRINGCDSRPVKKDM DYYVDQWLDVLERIDENLERLSVSLSLWEDVLSINDEIDGWSSSSISQMSENITNLNSSQ HMKACLEEFQTEVTHKGQKLEAFHSKINDLKELTRSRDPPAELQFMAADLKQKLEHAKEV SQVAKGTLDDFNTQKMQLETFIDQMTDWLNKVEESVLKYQNSREPEDMKKLKDIQKELQT QQSSIDTTQENLNTLCRQFRSTELEVIGAAVTTLVKKYEATNQLCFKMQAALQETLEKQF TESMGAFDEWFEEMKRDVKGFSDYSGDSKTLEGKIQQFQEILDSVGEGQRKLDAANEEGE KLYFCLPKPIVLSIQERVSNTEKEFQSFRKQCLKDKQTLEDCISNLGSFEDEHKKLSMWI HELEERIRTEALGESKQHIPEKKSEMHKVEMFLEELMAARDSLEKLCQRAQTLHKDGRGD GQEVRLSSQLNTNYQNLVKILKEKLRICQVALQEHQIFEEALQTTWSWLKDMQDKLSTVE STVGSKSTLENRLQQVQDMLLMKGEGEVKLNLAIGKGEQALKSSNMDGQMVIKMQLQTLK DVWETVNSTAARCLSGLDCVISQWNAYIERKNQMEQWLESVDHKLEQPIQHQNGLKEKFA LLDHIQAIVSDIENHATTLHHLIEKTRDLHQKTEDTTFSEVAQNELKTHFNDIMTVAKEK MRNVEDIVKDHLMYLDAVHEFSDWLHSAKEELHRWSDASGDAAAIQKKIAKIKELMDSRQ TGAERLSRVETLVPAVKKNTTASGCEQMEAEIQGLQADWKQWQESVCQSQNALQALSSQM AISEQEFTSGVSKLEDGVQDFSVFLSKWTQKLMQGEGKNTDKEVVEAWHRQKEALSILTE AEHVTDGLKTQLNDLCKFSKDLGVYSSKVSALIKDYNSLCLQTSKSCQSKEEILQQRFRT AIRDYQQWLVNAKVTTAKCFDTPQSIDETSASLQRIQECLSESDNGQQKLHMVTSRGELL CSIMPEEKVKTIQKKVLAAKEDWKNFISSLHLKESALENLKVQMRDFETSVKPVQEWLTN TERVVQDSNNRLHDLPSKRKEQQKLQSILEEISYHEPQITRLKEKAQQLREGQSANKSYM HRVSQLASQYLALCNLTKEKMSRMDRIVVEHQQFLQGLTDLQDWINDAIHLLQTYCHPTA DKSVLDSRMSKLETLLLVKQDKEIQMKMILTRGESVLRNTTPDGAPAIQQQLKDLKDSWA CLLSSCIKCKSQLEGALSKWTSYQDDVRQFSLWMDKVEERISEPERQFSELRDKITAQSK AKLLNEELLSHSSLLETIEKKGSSMTEHYVTQLELQDLHERYSTLKEKVKEAITKAEKIV SDHQNYQKALRAFEDWIQQENEKLNCLVLFDGDAEMYDSTLRELQELQVRCAEGQALLNS TLHIREDVIPWGIPHTEDRELESLRHDWQVYQQRLTEGRSQTNASFSKLKLMEKKFQKID EWLTSVEGKVNIRTGRQSDRATKEIQRQQMKKWHEEVMVYRDEVEEVGTLAQQVLEEGRS SRIGSMATLLTSRYQAVRLHTLEQIQFLEEEIRNIEEADVAMKYYTDWFTDALQNFKNIT ADLGVVDKTALEKKMKNLESLLGDMDLGNRLLKALREKGDRVLKYLAGDEADQLEKDIHN HMEKLEELTSSVRKEHTALEKGLHHGKEFSDKYSGQIQWLTEYQNVLQADVESKTELYEK KAQLAKYKSIQQTVLSREPSIKVVIEKGEALLRMTHNAFVDEKIHKLQKDYQGLCSLAKM IVAELEDKVKEHECYNSELQDVEKWLLQMSSRLVTPDLMESSNLEAITQQLANHKAMMED IAGFEERLSSLKLKGENLVLHCAEHLQAKFKQTIQAHLQGTRDSYSAICSTVQRVYLSLE NELQKHVSHQDTLLQCQAWYSSVKKELEEKAKAPLSLAEATKQVKHYRTLQEQANTYLDL LCTACDLSDGAVKNVAISIQQMKQTIEQRMMKSQDLANGWEEVREMKLELQIYFQEAGQQ LQDLKRRRAELEIKLAQNMVSQLKEFSQKLQSQQDQITRFTEKVNKLTSGQESPEHADIG QLSNRWLELCFQINSLLQQREEDLQRTRDYHDRLNIVDIFLDKLTTEWDNLARSDTESTA AHLEALKTLGSILQERRFALEDLKEQKQKIVDHLNVDDKELVKEQTSHFEQRWTQIEELV KSKIGTCATTLEELSFLNSRLQELTEWAEDQQPSMSEALKQSPPPELAQNLLMDHLTICS EVETKQVLLKNLIKDTDKIMGNLGLNERQKLQKVLEDSQKHVDCLSDLVNQRKKHLNKAL SERAQFLMAAYQALNQIQHHEKKIMFQEHICLLPDDVSKQIRTCKNVQASLKTYQSDINS LWNQGRELMKEATEQERSEVLGKLQELQNVFDITLQKCGQRLIELEKSFVSRIFFKEDLD KACHWIKQADVLTFPEINLMNDDSELYSQLSKYQKILEQAPEYENLLLSMQRNGQEILPS LNEVERSYLDEKLNSLPQQFNCVVTLAKEKLSKVQEAIFLRKEYVSLIDLTSKALKELED QLLLMYKFPSSLSAEEALKLQQDYASLLNEVVALGTAVNELNQKKEIFRSTGQPWLPEEM LQLVCQYHKLKRTMEQKVSQLADIKDAYRKNEDLCSKLKIKFEVLNKELEEVNKETLPAE DKLKSYRTLSASLHNAGTLLRQVTEHLEELSPTLDPSAYEAAELEVQQWHEKLKSWHAVM KDRMGECENRLIQSIDFHIEICRTLEWLRQKKVELNEPLALDGKLESVQEEMRKLQIQQE EIASSLRIMNALSNREKQKYLKAKEFVPADLDKSISELSELDRDISEVISGRQSALDKMY ITCQRYHQALQFASSWLEEAYQMLQQTSNGVDIETAEDTLRDYTDFFTTEIKINALIDEL RVLISELEGCVDKSGLDQLKQALGSIKKRGKGTMEQAQTQLELLRRCTVQWHLYQEERNQ VVISLNEAEKKLFKFSLIKDISCHKAEEKLVAHKTLVNLVNSFHEKITVLEEKASAMEKL GNNASKAIISKSMSTVWQRWTRLRSTAREQENILEEAVQEWKELSAKIQESTLAIDQLQE HLPDSCTEKASKAELVELLESHETFSRDLEQEYSVVTHLRQHALNGLLRDVYTESASVED LPVIQEMKAMLDRCSNMQQKVKKSKKLVEQELKEREDVEKELNIVQSWIRDTKETLLNSA SEGDLQLEEFQVLQQDLNSHRQKVEKLSEEQQNKYLEMYTILPSELSLLLAEVALALASI NEEIQMKQKEAQQNQTLNQELNNQIAETEGELNSILGRLTEKAVDVTEARKDHTILCEEL DKCNIKLVELDAAVQDFAEQNHALGKQLVDKIGKLIELQQQGSKQAEYRAGKVKQAVIQL EEYNEMLEFILRWIEKSKILVNSSIIWNSASQLRDQAMAHQAMLEESRDIHGDLEAMNEK IEYLSSVYHTEELSQQVSELGRQTEELQQTIKHRLLNLQDAAKDMKKFESEVRALQTALE QAQTTLTSPELGRLSLKEQLSHRQHLLSKMESLKPKVHAVQLCQSALRIPEEVVTSLPIC RTAVRLQEETSRLQHTAIQQCNIMQEAVVQYEQYEQEMKHLQQLIEEAHRKLQDAKVTTS NIQELQFQIKRHEELAKKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLTEGME ELDAELLTAHSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTD ASVNQDIAYYQALSAEQLQTDAAKIQPKTSSPQEMYESGIEIAANAKLDDLQRSWETLKN VISEKQRTLYEALERQQRYQDSLQSISTKMEAIEVKLNESLEPCKTPESQMAEHQALMDE ILMLQEEISKLQASFADELVSESLDSETADQLALQSTLTVLAERMATIRMKASGKRQLLE EKLNEQLEEQRHEQALQRYRTEADELDHWLLGARATLNNVLRALEEPMGMEAQLVDCQNM LLEIEQKVVALSELSVHSESLFMEGKAHTKEEAEQLAMKLRTLKGSLLELQRVLQDKQIS IQAKLAWGEMKAHKKVENGTFHETEESEAELSSSQSPSVQEWLAQARTTRSLQKQNSLQR QKELEQELAEQKKLLQSVASRGGEIINQQTTSDRSNISEGPDSLSRELGLEGVKPTSLDQ MRKKWETLHQELCTKEKLVQNSLQQEQEQPMFNKTNRVISGVPFYKGDKQVQDKSEVTNI LDGLNQALEDVSSQNGFGEKKILPVEKKLYEAVSATSTWLDDVEERLFVQTALQPEQTET CLYNQETLAKDIKEMTEEMDKNKTLFFQTFPSSRDHHEIIEDTLYCLLGRLNSLESVVNN RCCQMKERLQDLLTFQNDLKVLFTSLADSKYIILSKLAEAAERPAKDQMQAIMQAEDSLK ELDNEIAELKKHGDKLQVDQQSMQELSKLQDTYDELMMVISSRRSGLNQNLALKSQYERA LQDLADLIETGQEKMSGGKKCIAASRHEVNIMLQKHKEYFQGLESHMILTETLFRKISSY SSSRETQHHSDLMAKASAVLKQSHKRGVELEYVLETWMLLDDKYLELSKQLESIESNIPV VGLVEESEERLTERIELYQCFRSSLAEHQPKLYQVLEDGKRLLMSVNCPELEGLLSQLGE QWLNNNTKVSKELNRLENILKHWTRYKNESAELLHWLHSAMDRLDFWTEQSVTVPQELET VRDHLNAFLEFSKEVDAKSSLKSSVLSTGNQLLRLKKVDTASLRSELAQIDNQWTELLTH IPVVQEKLHQLQMDKLPSRHAITEVMTWISLMENVIKEDEEKIRNVVGCEAIHEYLLKYK GFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEKLGTMNRRWQILQGLITEKI QMLERLLESWTEYKNNVQSMKSWFEKQEKKLQKHQSIGDQASVQSSLKECQDLEEAVKAK ENDLEKVGQSGISLVQNKKERATAIVMDTIGELNQSWANLHCKVCQLEILLQSVLDQWSI YKEVYEELNGYLMEARYSLSRFRLLTGSMEAVKVQVDNLQSLQEELEKHEAVLDKFGSVT NKLLNECNSSVGESLRSTLTEVTTRWNCLLEDISEQLHSSKTLLQLWQKYKDLCIQCTNS VQLQEDRTNQLLKTASNKDIADEENATWIQECNVLLKNLFFAKSSLAVLQETGEQLKLQV DSSAAATILSDHLSLSQRLSVLEQALQRQQAILQAGVLDYETFIKSLEDLEMWLLEAVEV LNGQDPNRSSDLSTIQDRMEELKRQMLKFSSMAQDLDRLNELGYRLPLNDKEIKRMQCMN RTWTMVSSQTTERFSKLQSFLLHHQTFLEKCETWMEFLIQTEQKLAVEIPGNYQSLLEQQ RAHELFQAEMFSRQQILHSIIADGQRLLEQGQVDDRDEFNLKLALLSNQWQGVIRRAQQR RGIIDSQIRQWQRYREMAEKLRKWLVEMSYQPVTGLGSIPIPLQQARTLLDELQLRDRVL HRQQGSYILTVEAGKQLLLSADSEAEASLQAELIDIQERWKATTVRLEEQKKQLAFLLKD WERCENGIAESLEKLRTFRKNISQSLPDHHDELHTEQIHCKELENAVQGWVEDLAHLTEL KNSFSPFINADDISILNERIELLQRQWKELCHQVSVRRQQVSERLNEWAIFNEKNKELCE WLTQMESKVSQNGDISIEEMIDKLRKDYQEEIAVVRENKIQLQEMGERLAKASHESKASE IEYKLSKVSDRWQHLLDLIGARVKKLKETLLAVQQLDKNMSSLRTWLGHIESELSKPIVY ETSDSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACANDTECDSIQQATR SLDRRWRNICAMSMERRLKIEETWRLWQKFLDDFSRFEDWLKISERTAAFPSSSGVLYTV AKEELKKFEAFQRQVHESLTQLELINKQYRRLARENRTDSACKLKQMVHEGNQRWDNLQR RVTSILRRLKHSIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQ EIALNNNKIDQIITQGEQLIEKSEPLDAAVIEEELDELRRYCLEVFGRVERYHKKLIRLP LTDDEHDFSDREMDGDEAADLSDLAWHTKTAGGSPSPLPSSNHSLSLVVPMRSERSGRDT PASVDSIPLEWDHDYDFSRDLETAVSQVLDSDEEDDDERVQNYFSQGATGYTDVEIPESP EAYIKFTENVLKQSAGESILLETQICQLDKALDASRFHLQQTENVIRSRTPTGPELDSSY TGYMKLLGECRGSIDTVRRVNDNLKEEEEKLSGFINLNSTETQSAGVIERWEVIQAQALN KELRMKQKLQQWQQFISDLDNIWDWLGETEEELAQLRRLDVSTDIHTIEQRIKKLKELQK AVDGRKAIVLSINLCSSEFTQADTSESKELQERLRQMNLRWDRVGSTLEDWRCSLQDALM QCQDFHEMSHSLLLWLENIDRRRNEIIPINPSLDADTLQDHHKLLTQIKRELLESQLKVA SLQDMSCQLLVNAEGKDCLEAKEKVHVIGNRLKVLLKKVTQHIKQIEKILDISSSQLELS SWSSADELDTSGSLSPVSGRSTPSRERTPRGKCNVSQPGPSVNNPPSRSKDGGSGSCHSD ASVVQGHQSFFLRVLRAALPLQLLLLLLIGLACLVPMTEEDYSCTLSNNFARSFHPMLRY TNGPPPI NT seq 26484 nt NT seq  +upstreamnt  +downstreamnt atgtcttggtgtaaggaagttggtacccggaaggtttcctccattaacctggtgcctgga ttcttccagtatcttcgggatgagcaagaagcagttcaaaagagaactttcaccaaatgg atcaattcacatttggccaagcgtaaccctccactaatcataaatgatctttttgaagat ataaaagatgggaagaatctgcttgcgttattagaagttttatccggacagaaactgcca tgtgagcaggggaagcatttgaaacgcattcactgggtggccaatattggtgcggctcta aagtttttggaaggaagacggattaaattggtgaacataaactcaacagatatagtcgat ggaagaccctccattgtgctcggtttgatttggaccataatcttatattttcagatcgaa gaattaaccagcaatctcccacaacttcattcactctccagtagtacttcttctgttgac agtgtagtgagttctgagactgccagccccccaaccaaacggaaagttgttactaaaatt caaggaagtgccaaaaaagccctgctgagatgggtgcagtacacagccggcaagcgtctt gggatcgaaataaaagattttggaccaagctggagaaacggcattgccttccactcaatg atacacgcaataaggccagaacttgtggacatggacaagctgaaaggaaggaccaaccat gaaaatctggaagaagccttttcaattgcagaaactgagctaggaattccaaggctgctg gatcctgaagatgttgacgttgacaagcctgatgaaaagtccatcatgacctacatagct cagttcctaaaacactatcctgatcctcacaactcatcagcagatggccaaggagatgag agagaagacagactggtgcttcgggatctaaaagtttggattgaacagtttgaaagggac gtcacaagggcacaagtagtagaaagcagtttacaggacagataccagtcatacaaaacg tatagagtacagtatgaaatgaaaaggaaacaaattgaaagttccattcagccattgggc aaagatggaaaactatcacttgaccagacgatggtgaagcaagcatgggacaaggtttct gctaggatttttgactggcatgtacagcttgacaaatctctaccagctccattaggaacc attggctcctggttatatcgagccgaagttgcactcagggaagatattattatgcaacaa tctcatgaagaaacagcaaatatgatacatagaaaactagagcaacacaaggacgtcctt aagaatctggatggttataaaaaggcttttcaggagatccaccgctcaggatctgtcaac ggagttccggtccctgtagagcagctcgaagacatggcagaaagattcagcttcgtagcc tcctcctctcagctccatatgatgaagttagaattcatggaattgaagtatcgactatta gcacttctagtgcttgcagaatctaagctgaagtcctggatcataaaatatggcagaaga gaatctgtggagttgctgctacaaaactatattacatttattgatggcaatagattcttt gaccagtatgaatttaccagtcagtcattaaagcaagctgctgagatgtatgtaaaagct gatggatcagctgaagaggctgaggttgtgactaaatttttgaacgagactactatccag tggaggaatctgtcagtggaggtgagaagcgtcaggagcatgcttgaagaagtcattaac aactgggagaaatacagcaatacagtcggcagtttacaagcctggctggaagacgcggaa aagatgctggatcagcccgaacatgccaaaaaggagttctttcgtcacttgccgcacatg atccagcagcacactacaatgaacgactctgggaatttcctgattgagacttgtgatgac actgtgtctaaagacatcaaacagcagctcctgctactgaatggtcgatggagagagctt tttgtggaagtgaaacattatgctcgagcagatgaatttgagcgtgcaaggaaggaatat gcagatggcttgatagcacttgcagcattcgcagaaggaggcaacgagaggatctccatc cctttggaagtgtcctttctgaatgttaagatgttcgtccaagatttagaggatatcaaa cagaaaatgcctgtcattgaagctcagtataagtctgtgacaagaatggcgcagcttctc actaaggagtctcctcagtctgaatcctctgagatgttggcagcggtgtccaggataaag gaccagctcaacaaaataagagagaggtaccccccactgctttatgaatctcaacagctt cttgcaccacttggagactttgagaatcagatgaccaacttttatgagtgtcttgagaaa ctgagtgaaattatctcactgtcggacttggatttacagtccacttctgtcttgaaacaa aaacagcgggaactattgatgtaccaagagagctgtaaaaaggccttggtcgtaattgag aagaatggtcaagcggtccacaaagcgttgacaatcagtaaatctttacaccattttgac cgatcttgcctccagaagaaaataacagatgctcagtctgcgtttcagaatatggcaaag aaaataccagaatggcagaagaaggtggagttcaataacagcatgatgaagaagtttgaa gagtcaagaagagaacttgagaaggttctaaaaacagcagaatcatactttaaggaaaaa ggaaaccctgaagaacttctgaagaagcacactgatttcttcggacaactagatctgaag gtgctcaacactttcctaaaagcttgtgatgagctgacagatatcctaccagagcaggac cagcagccattacaagaaactgtccggaaattacataaacagtggaaggattttcagggt gaagctccttaccacttactgcgactgaaaattcagctggagaagaatcggattaatggc acaattgaagaatgtcgtgcagagctgaccagggagaacaaagttctaccagtagatgga agtgaaaaagttattaaagaacatcgggcattttttggggaaaaaggctgctaccaactg tgtgagaagagattacgccttattgaggagctgtgtttgaaactacaagaaagggaccct gtaaaaggagtgtacgaaagcagcagagagctgctgaaagacctaaaagctcagattgac ggcacacacctaaaactaatggaaaatcccgataagtggaaagatttcgggatcaggtta actagaataacagattggcttgtggcaaaggataggcagttgaagcagattaaaaatgaa gtaacagaagcttctaaatatgaacaagtgaaaacttcagtgcagaatatcagacgtgat gcaaggaaacaagaagatgaacttggatacctgaaagacaggctgagtgcactcactgtg gttgctgttgagacagaaattaagaagcaaggcagtaatctatccagagcgtctgctgat ctgaaagtcctactggactctctcagtgaggctgataaaatcctgagcaatgttggagat tgtgtacagtacaagacagaagtcaaaaatgtgctgagtgagatactgaccagttccaaa gatgtgctgtcagaggctgagaagatcctggacacagaaagctttgaggaggcccaggag atgctttttcattatgaggaaaagataaagaaaattcaatctaagaagcaggatgtacag gtccaaattgctcaggcgaaacagttacagactacgcaaggattgtccaaagacattgaa gaggactttacaaagatggaaactgaattggacaaagtggaaacgacaatgattaaacag aaagaaagcctaaaagatacaatacacaactgggaacaaatagaaactagcaaaaaatct attgtgcaggacctgaagcacatggagtctacgttagaacgacctttaaactttgagaca ttggaaagtttgtcatccgaacttcagcaggcaaaggaggtgggtaagagaatggaagat ctctcagtgcaagcagaaaaccttgttgagaaatcatctgatattcaactaggaaataac agcaagcgccacctgcaggagaagacaagatcagttcaagacaatgtgaagcatgttaaa gagaccctgactgaaaacatcaggaaaacagagatggctaaagatacttggcagaggttt gaccgtgattttgcagcacattccacttggatttcggaaagagaaaaggaactaagtgat ttagaacggtctgatatttccgcagaactccaagtcacacgcatccaggaaatattgaaa gaaatgcagaataaatctaatgcagtaaaggagctggaggcacagagccaggcatttact gaatttataagttctgcagagatggctcggataaaagccaagctatcacagatggccaag 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caactttgccaaagtgccttaagaattcctgaagaagtagtgactagccttcccatatgc cgcactgctgtcaggctgcaggaggagaccagccgtcttcagcacactgccattcagcag tgtaatattatgcaggaggccgtggtccagtatgagcagtatgaacaagagatgaaacat ttgcagcagctgatcgaggaagcacatcgaaagttgcaagatgcaaaagtaactaccagc aatatccaggaattacagttccagattaaacgccatgaggagctggcgaagaagatcaag ggctatcaggagcagatcgcatcgctcaactccaagtgcaagatgttaaccatgaaagcc aagcatgccacaatgctgctgactgtcactgaggtggagggactgacggagggaatggag gagctggacgctgagctcctcactgcacactctgcgcacccatctgttgttatgatgacc gctggtcgctgccacactcttctgtctcctgtcactgaggaatcaggggaggagggtacc aacagtgagatctcctctccacccgcctgtcggtctccttcacctgtggctaatacagat gcttctgttaaccaggacattgcttattaccaggccttatctgctgaacagttgcagacg gatgcagcgaagatccaaccgaaaaccagttcacctcaagaaatgtacgagtcagggata gagattgctgctaatgccaaactagatgatcttcagcgctcttgggagaccttgaagaat gtgataagtgaaaagcagcgtactctatatgaggctcttgaacgacagcaaaggtaccaa gattctctccagtctatttccaccaaaatggaggccattgaggtcaagctgaacgaaagc ttagaaccctgcaaaaccccggaaagtcagatggccgagcaccaggctctcatggatgag 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aattctttacaacaggagcaagagcagccgatgttcaacaagacaaacagagttatttct ggggtgcctttttacaaaggagacaaacaagttcaagataagtcagaagttaccaacatt ttggacgggttaaaccaagcactggaagatgtatcttctcagaatggatttggggaaaag aagattctccctgtagagaagaaactttatgaagctgtttcagccacctccacctggttg gatgatgtggaggaacgtctttttgtacaaactgctctacaaccagaacagacagaaact tgcctttacaaccaagagactttagcaaaagacattaaagaaatgactgaagaaatggac aagaacaagactctgttttttcaaacatttccaagcagcagagaccaccatgaaatcatt gaggataccttatattgtcttcttggaagactgaactccttagagtcagtggtcaacaac agatgttgtcagatgaaagaaagactacaggaccttctaacctttcagaatgatttgaag gtactctttacgtctttggccgatagcaaatacatcatactgagcaaactagcagaagca gctgaaaggccagccaaagaccaaatgcaggcaataatgcaagctgaagatagtttgaaa gaactggataatgaaattgcagagttgaaaaaacatggagacaaactacaagtggaccag caatccatgcaagagctatccaaacttcaggacacctatgatgaactcatgatggtcatc agctccaggagaagcgggctgaatcagaaccttgccctaaaaagtcagtatgagagagcc ctgcaggacctggctgatctgatcgagacaggacaggagaagatgtcaggaggaaagaaa tgcattgctgcttctagacatgaggtcaacattatgttacagaagcataaggagtatttc caaggactggagtcgcatatgattctcacagaaacacttttcaggaaaatcagcagctat tcttcatccagagagacgcagcaccactcagacttgatggcaaaggcatcggctgtgcta aaacaatctcacaagagaggcgtagagctggagtatgtgctcgagacgtggatgctactg gacgacaagtatctagaactgagcaaacaactggaatccattgaaagtaacatccctgtt gtgggtctggtggaagaatcagaagaaagactaacagaaagaattgagctatatcagtgc tttaggtcaagcttagcagaacaccagccgaaactttaccaggtcctagaagatggaaaa agacttctcatgtctgtcaactgtccagaactggaaggcttgttgagtcaattgggtgaa cagtggctgaacaacaataccaaagtgtccaaagaactgaatcgattggagaacatactc aagcactggacaagatacaaaaatgagtctgctgagcttcttcactggttgcattctgca atggataggctggacttctggactgaacagtctgtcactgtccctcaagaactggagaca gtcagggatcatctgaatgctttcttggaattctctaaagaagttgatgccaaatcctca ttgaagtcatctgtcttgagcactggaaaccagttgcttcggctgaaaaaagtggataca gcctcactccgttcagaacttgcacagatagataaccaatggactgagctcctcacacat atcccagtagtacaagagaagctccatcagttacaaatggacaaacttccttcacggcat gctatcaccgaagtcatgacctggatctcactgatggaaaatgttatcaaagaggatgag gagaaaatccggaatgttgtgggctgtgaagccattcatgaatatcttcttaaatataag 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gcagatgaagagaatgctacatggatacaagaatgcaatgttcttttgaaaaacttgttt tttgctaaaagctcactggccgttctccaggagacaggagagcagcttaaacttcaagtc gattcatctgctgctgcaaccatcttgtctgatcacctttccttgagccagcgtttgtca gtattggagcaggcactccaaaggcaacaagcaatcctgcaggccggtgtcttggattac gaaacatttataaagagtcttgaagaccttgaaatgtggcttctagaagcagtagaggtt ctaaatggacaggacccgaaccgatcatcagacctctcgacaattcaagacaggatggag gaactcaaaagacagatgttaaaatttagcagcatggctcaagacttggatcgtctcaat gagttaggatacagactaccactgaatgataaagagatcaaacgcatgcagtgtatgaat agaacttggacaatggtctcatcacagacaacagaaaggttcagcaaattacagtctttc ctactacatcatcagacctttttggaaaaatgtgaaacttggatggagttcctgatccag acagagcagaagcttgcggtggaaatccctggaaattaccagagtcttttagagcagcaa agggcacatgagctgtttcaagccgaaatgttcagccgtcaacagattttgcattcaata attgccgatggacaaaggcttcttgagcaaggacaagtggatgatagggatgagtttaac cttaagttagccctgctgagtaatcagtggcaaggagtgatccgtcgtgctcaacaaagg agaggaatcattgatagccagatacgccaatggcagcgctacagagagatggcagaaaaa ctgcgtaaatggctagtggaaatgtcatatcagccagtgactggcctcggaagtatccct 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gaaaccagcgactctgaagagatacaaaggaaacttaatgaacagcaggaactgcagaga gacatagagaaacacagtacaggtgttgcgtcagttctcaatctctgtgaagttcttctt cacgactgtgatgcctgtgccaacgacaccgagtgtgattccatccagcaggctactcgt agtctggaccgtaggtggaggaacatctgtgctatgtctatggagaggagactcaaaatt gaagagacctggagactgtggcagaaattcctggatgatttttcacggtttgaagactgg ttgaagatttcggaaaggaccgctgctttccctagttcttccggtgtgctctatacagtg gccaaagaggagctgaaaaaatttgaggctttccaaaggcaagttcatgagagtcttaca caactggagcttataaacaaacagtatcgccgcctggcccgggaaaaccgcacagactct gcatgtaagctaaagcagatggttcatgaaggaaaccagcggtgggacaacttgcagaga agggtcacctccatcctcagaagactgaagcattctattggtcagcgagaagaatttgag actgcgcgtgacagcattttagtgtggttaacagaaatggacctccagttgacaaacatt gagcatttctctgaatgtgatgtgcaggcaaaaattaaacagctgaaggcctttcagcaa gaaatagcattaaacaacaataagattgatcaaattattactcaaggagagcagctgata gaaaagagcgagcctctagacgcagctgttattgaggaggagctggatgaacttcgaaga tactgcctagaggtcttcggtcgcgtcgagcgatatcacaaaaagttaattcgtcttccg ttgactgatgatgagcatgacttctctgacagagaaatggatggtgatgaagcagcagat 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