Bufo bufo (common toad): 121000925 Help Entry 121000925         CDS       T07950                                  Symbol OBSCN Name (RefSeq) obscurin isoform X1   KO K17531   obscurin-RhoGEF [EC:2.7.11.1] Organism bbuf  Bufo bufo (common toad) Pathway bbuf04820   Cytoskeleton in muscle cells Brite KEGG Orthology (KO) [BR:bbuf00001]  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     121000925 (OBSCN)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:bbuf01001]     121000925 (OBSCN)   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:bbuf04131]     121000925 (OBSCN) Enzymes [BR:bbuf01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.1  non-specific serine/threonine protein kinase      121000925 (OBSCN) Protein kinases [BR:bbuf01001]  Serine/threonine kinases: CAMK group   Trio family [OT]    121000925 (OBSCN) Membrane trafficking [BR:bbuf04131]  Others   Rho GTPase associated proteins    Rho guanine nucleotide exchange factors (GEFs)     121000925 (OBSCN) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  I-set Ig_3 ig Ig_2 V-set Pkinase Ig_5 Izumo-Ig C1-set Ig_4 Ig_6 PK_Tyr_Ser-Thr V-set_CD47 fn3 SOS1_NGEF_PH RhoGEF Egh16-like Ig_DSCAM-DSCAML_C PH ABC1 Pur_ac_phosph_N IQ Kinase-like APH YrbL-PhoP_reg SH3_2 Motif Other DBs NCBI-GeneID:  121000925 NCBI-ProteinID:  XP_040287640 LinkDB All DBs Position 5:complement(562023706..562645994) Genome browser AA seq 10334 aa AA seqDB search MDSSSFSGVPRFLTRPNAFMMSVGKDATLSCQIVGNPAPAVTWEKDKLQIQSGGRFKMVQ DGELYQLTIYDLSFQDSGQYICRAINNIGEAFAAVTVKVGETSAVVECAPYFILKPTSSR VSLGEDTTFQCRVQGHPSPVVTWEKDDRLLGTAVDSNRLRVESQGESSALRIHCIRFSDS GTYLCRAENSVGQIKASASLSIESFSNVNTNNTGAMESSYGKTASLLSHLQKRREEMRKT DLSIMGSYDLNTTSYGALDTLTGLGLSLDYERAATLAPKINREGAMSVLTRTCTVTEGKH AKMSCFVTGEPKPEIVWKKDGEVITEGRRHVVYEDEQENFVLKILFCKQSDNGLYTCTAS NLAGQTYSSVLVIVKEPRIPFRSKLQDLEVREKEAATFQCEVPQTITESTWYKEETKLQQ SSKYNMEAEGTIRRLTIQNITTDDDAVYICEMKEGSRTIAELSVQGNLIKKLPRRTAVPV SDTAIFCVELDNDCEKVRWTSNGQSVVPDGRISITSSGKQHTMIIRECKNSDSGEIAFIA DECKTSTQFTVTTLRKPPSNAPINPVVTDKTETSVRLAWSPPPMDRPVPIDGYIVERKKL GAMTWVRCHESPNVPTPEFIVRHVPDEGSFQFRVSALNSYGQSPHLEFPGTLYLEPVPSI KTPLKPVDVAFGAEATFSVDLTTVSPGSWWINGKVVESNDQYVVKRVKNTHMLLIKSVTQ QEDQADITFTCKGIESSTKLRVRALPHFTTSKRLSEVQLRSGDQAEFVSETSEENVRVLW YKNGKEIRHSKKFQLESRGKLQKLQISCVQREDEGTYTCSLGDDIITFSLQVTEPEPAFI NQDKVQKEVVAKLTESAVLSCEVSERKTEVKWYKDGKLITSSKKLRVETEGKYRRLVVEQ VEKKDAGEYSCEVAGQKISFKVNVKEPEPAFINQDKVQKEKVAKLTESAVLSCEVSDGKT EVKWYKDGKLITSSKKLRVETEGKYRRLVVEQVEKKDAGEYSCEVAGQKISFKVNVKEPE PAFINQDKVQKEVVAKLTESAVLSCEVSERKTEVKWYKDGKLITSSKKLRMETEGKYRRL VVEQVEKKDAGEYSCEVAGQKISFKVNVKEPEPAFINQDKVQKEVVAKLTESAVLSCEVS DGKTEVKWYKDGKLITSSKKLRVETEGKYRRLVVEQVEKKDAGEYSCEVAGQKISFKVNV KEPEPAFINQDKVQKEVVAKLTESAVLSCEVSDEKMEVKWYKDEKLITSSKKLRIETEGK YRRLVVEQVEKKDAGEYSCDVAGQKISFKVNVKEPEPAFINQDKVQKEVVAKLTESAVLS CEVSDGKTEVKWYKDGKLITSSKKLRVETEGKYRRLVVEQVEKKDAGEYSCEVAGQKISF KVNVKEPEPAFINQDKVQKEVVAKLTESAALSCEVSDGKTEVKWYKDGKLITSSKKLRVE TEGKYRRLVVEQVEKKDAGEYSCEVAGQKISFKVNVKEPEPAFVNQDKVQKEVVAKLTES AVLSCEVSDGKTEVKWYKDGKLITSSKKLRVETEGKYRRLVVEQVEKKDAGEYSCEVAGQ KISFKVNVKEPEPAFINQDKVQKEVVAKLTESAVLSCEVSDGKTEVKWYKDGKLITSSKK LRVETEGKYRRLVVEQVEKKDAGEYSCEVAGQKISFKVNVKEPEPAFINQDKVQKEVVAK LTESAVLSCEVSDGKTEVKWYKDGKLITSSKKLRVETEGKYRRLVVEQVEKKDAGEYSCE VAGQKISFKVNVKEPEPAFINQDKVQKEVVAKLTESAVLSCEVSDGKTEVKWYKDGKLIT SSKKLRVETEGKYRRLVVEQVEKKEAGEYSCEVAGQKISFKVSVKEPEPTFINQDKVQKE VVAKLTESAVLSCEVSDGKTEVKWYKDGKLITSSKKLRIETEGKYRRLVVEQVEKKDAGE YSCEVAGQKISFKVNVKEPEPAFINQDKVQKEVVAELTESAVLSCEVSDVKTEVKWYKDG KLITSSKKLRIETEGKYRRLVVEQVEKKDAGEYSCEVAGQKISFKVNVKEPEPAFINQDK VQKEVVAKLTESAVLSCEVSDGKTEVKWYKDGKLITSSKKLRIETEGKYRRLVVEQVEKK DAGEYSCEVAGQKISFKVNVKEPELAFINQEKVQKDVVAKLTESAVLSCEVSDVKTEVKW YKDGKLITSSKKLRVETEGKYRRLVVEQVEKKDAGEYSCEVAGQKISFKVNVKEPELAFI HTDKIQKEVVVKLTESATLSCEVSDVKTEVKWYKDGKLITSSKKLRVETEGKYRRLVVEQ MEKKDAGEYSCEVAGQKINFKINVTEPEAKFLKTSEQKEAVFVQEHEDITLLTSVQPQNA QVKWFKDGTELSASKKYQISADGASRTLIVKTAESKDSAVYTCSIGSDKQEFRVQVKEIP VKFVKKLEAMTGEIGSSITLTCELSQAKGDVTWKRNGGEIKPNKRIQIRSDGGKRSLTIS QLKAEDEGEYSCESRDKTTIAQLRTKAPRVVKFTAELSNVVVEEGAEATFKCTISPDDAA VTWYRNGANIEKSNKYKFSKKGAIHSLSISQLTLQDAGEITADAEGVKTTATLKVREAPV LFKKKLEAITVEERHTVCLEVELSKATKDVKWMKNGVVLQSGNNIEIKSEGCKQILILKN VTYTDRGLYGCETLDDSTQAKLNVEMRQVKLVRGLRDVEVREKDSATFELELSHEDVDGS WMKDGLKIKSSESCKIIVNGRKHGLLLSSVKQEDAGVVSFKSEGIQSSAKLIVKEPPVTI THPLQDMTVEERDKVTFECQVSRANAEVKWLKDGSELRPSKKITIISQGNKRNLTIHKCE PDDKGAYVCDAGDNKSSAHLTVQARDIRFIRPLEDVDVTEKEAASFICQISHDDVQTQWY KNGAKLRAGDNVKMRQEGRTFSLTFKSVQAQDAGEIKLVAENAESCARLCIRELPVKITK PLRDKIAIEKHRAFLECQVSRASGEVTWYKKDKVIQTGKRYEIVSQERDRKLIINEVEFE DEDTYTCDAGDDKTSAKLLVEEQSINIVSELSDVEVMEPEKATFECVTSIVSVKPPKWIL GGEVLQDGKDLTIEQEGTVHRLTLWKTSSKMSGAIQFHIGKSKSTAHLVVTEIPVQVTQK LEDRTVSERQSVLFSCEFKPPPKFVEWFWGKTQIEASDRYRIKQERGTAELRIVKVTPED GGIYTCKVGPVETSAILTVQARDVKVLKPLADVEVEEESCAAFSCELSHDDEEVEWFLND TLLYTNNYNDIKKIGECHTLTLKQVAAQDSGTISLKTQKLTLTAELKVKEKPVVFMKSLD DAVGEERGMVTLKCEVSKPKVTAIWKKNDQLLPNGDKYHQIQAGKIVSLTIHNLNKADAG LYTCDIGTEVAKSKVSVQELNIGITKRLKSTEAKEGESCSFECVLSHESIDECSWTVNGV DVESDQRFEVSNKGRKYLLNIKEVKASDAGDVIFTARNLSSKATLTVREKPAIISKPLED KTSIAGEDIVLKCELSKEDTNVKWSKDGKVLRRNQKYEICQERTETWIIIHEASVKDSGE YICETSISKTKASVQIAEKPNRFIKEISDVKAEEGEAAIFTCEAERSPPTVKWRKSITEL KSSKKYELSQKGNVLSLTVNDLEKGDSDTYICDIGDAQCKASLTVTGHKVLIVEDLEDAE VFEGESVMFKCRISPAHYQKVQWFLDKTPLHTNEVNEIQALAGGYHTLYLKQLGVKDSGI VTFEAGNQKTSVKLLVKAVQAFFKREVQGTEAEEGAAATLSCELSNEKAAVQWKKDGELL QPSNKYEMKIRDRRVELLVHNLVKEDAGTYTCETGEQTSSAMLTVRAVQVLFKRGLRNEK SKEGSTVKLQCELNKSGAPVTWTKDEEILQSGDKYDIKQQSAVVELLILNAKPEDSGDYT CDTGDQKSTSHVTITAIPVRFKQDLQDCNVDEGSSVTLACEISKANAHVIWKKGVTVLQA NDKYEFRQKGTVVELVIHNVKSEDSSTYICDTGDQQTTARVKVQELPAHFTEELINQQAN EGASITLRCELNKPDAPVEWRKENTVIKPSKKFKIHQEGQTAELIIRDLAPEDGGDYTCI CGEHQATGTVKVTALPPLFKEELKNERASEGEDAKLLCELTKPGATIEWRKGDQVLKAGD KYTMRQEGVYAEMVIKNLDNSDSGHYTCVCGEQKTTAVLTVNALPILFKEKLTNTEAVEG ETITLHCELSKPVSSVAWKKGHATLKPNNKFTMILEGSVAELTIQDLDLKDGGSYSCVYE GEETMANIRVNEHPILFKHELSNVESTEGRAVTLSCEFTQPPPHVEWRRGHKVIKPGQKY EVRQDRATAQLIIRDLEQKDTGDYTCVCGERCSTAVLIVNALPVHFTHGLKDEDTAEGER LVLHCELSKPDVSVEWRKGRTLLQESEKYVLRQEGPVVELVITDLREEDAGIYSCVCGDQ ETSSTIHIKALPPRFTRELKSEDCTEGSSALLTCELTKANAQLEWRKGDHVLQPSNKYKM TQDGCTAELEISNVDLHDGGQYTCMCGDQKTSATLIVHALPPEFKEELKNQEAVEGDSVT LHCELTKPDASLEWRKGHKIIKSSDKYSVIQEGLVAELVVRNVDQHDTGRYICVCGDNQT AATLTVKAIPPQFKDGLDNTEGVEGESLTLRCTLTKPKASLQWRKEQKTLKPSSKYKFVQ NGLVAELVIHCLDLDDAGEYRCICGDHETSASVAVKALPPRFRKELKGKEISEGTSVTLC CEVTTSKALLEWRKGRKVLQASNKYRFIQEGPTAAMVIDNADVNDSGEYTCICGDHRTTA SLTVIALPPQFMEVLKDKEGVEGESVTLDCIMTKPKATLEWRRGKKMLTPGDKYTFIQEG LSAELVISHLDPEDAGEYTCVCGDQQTTATLNVKALPPLFKEELRNKEGVEGESVSLQCV LTKPMAPLEWRKGQKTLTPGDKYRFIQDVLIAELVISHLDPEDAGEYTCLCGDQQTTATL TMKALPIVFLEELRNEMLSEGQNATLRCELSKPGLPVSWKKNNSVITASDKYAMCQDGPV YELTIHNLQLEDTGTYTCLYGEQQSTAMLSVQELPVLFMEGLKNIDVLECGEAVFQCQVT KPNARLQWKKSQKTLQPNDKYKIRQQGVNAELVIRDVNLKDSGNYTCVIGEEATTATLTV FELPAHFSSELTNLEVMERGTAVLRCEVTKPSAAVQWKKGEKTIRLSDKYDIRQDGTRLE LQINDVELSDADQYSCVCEKQRTTASLTVIALPAVFTEQLKDLQVSESDTVTLHCELNKF GLTVEWRKGDVTLTPGDRTIMKQEGRAHDLLIRDVTVKDSGEYSCLCEGVTSSALLSVNA LPVLFKEELKKVDVLEGENVTLSCELNKVDVCVEWLKGDKSLQPGGRYTVQQVGGTATLS ILEVREEDDGDYTCVCGDAKSIGHLHVQALPVLFTRPLQNVDAQEEHTVTLQCQVSKAGA AVEWRRAGLGLQAGSKYEMQQKGNVRELLIHHLRLEDTGEYTCDSGDQETKAYLTVTALP VVFVKPLKNTVVEDGVTVTLRCETSKANVPVEWRKGTVGIFPCAKYEMKQEGAVSELVIY DAEAEDAAEYTCDTGDQQTSCTVKVNVLQFVKSLQSVEEEQGGSVYLHCEVSAKMASVEW WKGSEKLQPNNKYEMRQDGTMRDLIIHNLELEDAGEYMCTARSKRTSASLSVRELDITIV RGLTDLSVFVGEDAVFKCEVSHEKARDVEWKLQGILLENNQMNKISVEKEKSHVLKLSGV TQDDSGSITFRMGPYVSTAELTVKALPVVFEQKPEDQSCEEGSTVVIRAQISKANVEAKW RRGTTEIIPSEKIDIRQDGKTVELVILPAVPEDSGDYTCDTGDQEVTCNLRVTALPVQFT RHLQNVHGEENGSVTLRADISKPDAPIQWKKAGLTLKSGAKYEMKQSGCVVELCIHKLQP SDAGEYSCDTGHLTSVANVHVKEPEPFVVDQLQNVSVEEGEDAIFKCKVSKNNAPDVQWY LAGVPLQSNEMNEIAVHKGKIHTLTLKKVSLEDAGPVSFRVGQSTTAAELEVKALPLRFT KPLQPTEVDEKGEVALHCELSKPDITAEWRKGAAVIRPGGKYEISLKGAAHTLHIKDVTL EDSGEYSCHAVNERTSATLQVKALPLVFTQELHNIEPEEGRTAILQCEVSREGAPVEWRK GAVVLQSDDKYEMRQADRIVELMIHNVAPEDCGPYTCSTGSAQTTASVFVQAGNVEIVSG LKNTDVFAGEMATFSCELSSPDVRNVQWWLDGSPLQNSSVNEISVHRGRVHTLTLKNLGT NDSGVVTFKAGSLISTAKLLIKDPTIEVVSPMSDLTIDEDDTAQFICQYSRPVQAAWKKH DVDLCADGKRVIVEQDWNVAKLTIKSVVPEDRGVYVCEAGGTRIVAMLDVEEKNKILQGL ENVEALEGGEALFECYLSKPECYNYNWLVDDEAAKSSDNVEMVYFENGRRHLLLLKNLTA EDSCRVTFMAGDAVTSAFLSVRGWRLDVVKPPADTEVAAGDKAAFTCVLSEAVPVNEVSW YFNGAPIQPDENWSMIMDGNQYKLLLKDAQTHHSGEVAFASRDVVVSAKLLVLALPDPPE DPEIVSKTSSSLTLSWFTPRSDGGAPIVGYNVEMKSPGGDWQQCNMEIIQSMEYVVQNLE PGQPYRFRISSINKLGRGEPVHLPQTVQLEHPVMVHHPLQHKSATPGETLRLECELSKES CEVTWMKENEPLNPGKKYQIICEEKRQILLIHDVSADDQATYSCVTSSGDKTSATISLGI QTITELVTVQEALGLTHVRTDHVVEAEDSTQPNLPPEAAQEGDLHLLWEALAKKRRMSKE PTLDSISEVPEEDEKRKLKKEAERRADFSGYTSEDVAKTSEADFSLTSSDDESRAGTPSL VSYLKKAGKSTITYGSKVQTVSASKFFKHFETSNITEVKEPVKEPDLSEIFDDDPALDKA AVKIQAAFKGYKARKVIKQQECPMFTETFKDLSVEPGGTVHLECVAISKSDITAQWMKDG KELSDGRHYHIDNYPDGTCSLIITAVELQDTGNYTCEASNKFGQVCHSAKLVVDGGEPEI PQKPIPIPPKSSTDSETETSGSDLDDAFRKAGRRLHKIFKSRSSLEMSEEELFVSADEGD LPPIDHQTYREDDKFIYIKFEVMSEASVAAHRFREMFSAMGIKVKIDILEQGQKNIELRI MKVETGPTEQQKLQAKQQMTLLTSDTAPVFITELQNQEVADGYPVSFDCVVIGKPMPSVR WFKDGKAIEEDDHYMINEDQEGCHQLIITAVVLPDMGVYRCLAENRMGVASTKAELRVDL TSSDYDTAEATETSSYFSAQGYASREQESLESATEQEQLPQVLEELRDVLVAPETPIARF QIRVKGFPRPRVHWFKDGQPLHSSDRILVTSKRKAHSLEILNVSREDAGEYSTYISNSAG SAYSSARLTVKGPGELQKEKSAEDAGDLKKPVPPMFLERFTNKNVQKGASITLSVKVEGI PVPMVTWLKEESPENVLLIKPETPGYKLASSNMHHSLVLLDVGTDYTATYTCIATNKVGQ SICSATVQVLEEKEAQILAKADKIVKDILGSSVPGRIGTSVQPAEADGDSRMAQKTHISL TEVGTEEFFQKLTSQITEMVSAKISQAASLRVPTMPGMDSDDESKTPSASPRHGRSRPSS IAVESSSESEDGDSRGEIFDIYMVTADYSPITADKETITLKEGQYVEVLDSAHPLKWLVR TKPTKFSASRQGWVSPAYLDKRLKLSPEWGAGDVVEHPGETVSEEEYKKRLSTIIQDLLS SEKEYVTDLQFLQTHHLSYTESCTDVPEAVAIQKPVIFRNISDIGNFHARTFFQELKKSD TDDDIAMCFIRNEEEFNKYIMYLVGRVQAESVVVNDAIQEFYKGYAEDILALSDPSRPPA PPLQHYLERPISRIHHYQVILKEMIRNKARNSKNCALLEQAYAIVSALTRRAENFLHVSL MENYPGTLEALGEPIRQGHFIVWEGAPGARMAWKGHNRHVFLFKNYVIICKPKRDTRTDT YSYVFKNMMKLTNIDVNDQVEGDDRAFEIWHEREDSVRKYLLQARTVIIKNSWVKEISGI QQRFSLPLWNPPHFIEVLADCTAELGETVKLACRVTGTPKPTVTWYKDGRPVEVDPHHII IEDPDGSCTLILDNMTGADSGQYMCFACSPAGTASTLGKILVQVPPRFINKMRNVYFVEG EDVQLSCVIEGAPYPQIRWYRDSHLLPDSSKHQTFAEPRSGVLVLVIKNATKDDVGHYEC EMANRLGSTRSGAELNVQTAAMMERRGDQTVTIEGDGALLDASIRASLQRADQEIRQVLK KLMAPESGVTTAQDPPPTNTETAKSAEHSVLEDGRETADIFRDANTQTPEQATHDEARKA PVVSEATEAYPEVSSSETQTEPDVPERIIPIRLQMDAAERMRPPGAQIWDVHREVYIQTT QKTCRHVSPEREARPPYMQVTIEDVHTQQGETAQFDAVIDGSPPLTITWYKDNNFLVESD RNRLMREDRKYSLIIHRTEAGDGGVYTCVAHNSAGEVSCKAELVLHPDEKEQETKPQHKR RKLQSFFEVKEEIGRGSFGFVKRVVHKGNGATCAAKFIPLKSKTRQQSYRERDIISEVSH DRVTLLLDSFETKKTLILILEICCGEELLDRLFRKHMITEKEVKIYIRQLLEAIAYLHDK NILHLDIKPSNILMVHADRDDIKLCDFGFAQRIIASEFQYSKYGSPEFVAPEIASQAPVC KASDIWPVGVISYLCLVSASPFAAQNDRETLRNVQQGKINWSCPSFTRLSADARHFMMAA VHMSPDARPSARDCIHHKWFTASSGPEDIQPISSKNLRFLVARSRWQRSLMCYKSILVMR SIPELLNSKLESTSLGIPRHLVECSSSSSSSGSSSDNESDISPTAKDCNPSLELHLSIFK MSEKDTLQKCNTSESGIDREDNEDKKMENPDTSPMTRHKREHESVVGSNKSQRELEDDKK MLVHSVATSPGRRLKYRAATIEVGGLASKKPKTGSFIRGTSADSALLLQRAGDKPSLACV PRQSIINSTFYNQGSEGPGMAPQDGSLKDKDFIKHRERARRSLMKAGYSQKILSGLREPL LEQFTIEQRMLSDQDAQLSSLKKSASFDTAKSALRSSFKVSSRSRSLDDYKSRPLSIYKG TVVEEIDQDSLRAEQGTFKKTDTDIKLHSDNSIRPISLPPEIHQYSAPVKMSSTQRPLSA PTTDRENTIIAVFHQHPILQTSVSRERPSSVQPKVEESTVIAYVIPRQTPDSSAMKKTGT VKAPPQSSQHSIKDQGPSLDSQGGVTFTVHSTSEGNDFLTSDTSTEGDTCTELFMVDKTK GEGSKVFTEPKTEKLFQFVELSNDDNTRMTVICQGNIEEHVTANEEPDRSAGNMTDSVST PIQVGTATKSSEDTTPQDTIMAEVTVVQPDDGDLIKPPINQTMDLHKDHSEEKSPFETLE TIQKMELPAGGCDASPQDDDVGRDFQCPVYSAALEDLVGEMASLSDEMDALASEQRPVGQ EVPSHFPPVVPSGLQDVGPGECPAMDMDPSPVEEITKDLQMTSASQCSFYESLSRAEVST IESHSSSKTFISHSDSSGTGRRSDNFSDFDEAGRRSEVSLVEIGEMHHKQSSTSPELRQL DVDAACSQLHDFYDICTSPQTSLMIEDQKFNLSSPASKHPTDCGETAMETSVVLGKSTKD GLPLQPLQLLDHQQITTKDRKTSRKRIKLFRPHRKSEKNVKTPEISLKQKVKASVANISR IIKRKPGNGKEAGPSEMMKPSVTDHGAVGIISGSVKKKGLPTFKLPNLSGKDKAPAFVEE LTDQTVVVGHLVTLSCRTAQPVTDVEWYKDGIPIQSSERVLISSTLKNYHLLTILVVTMQ DLGIYACVASNVLGSASTCCIIKKAEIPCCPSRPEVAQVYKDGALIVWKPVESSTPVTYF LQYRKEGEEWRALTLDISDCCYSTRSLCEGHVYSFRIACISKAGMGPYSESSAAVRIGRL SPAHGQLSGALEPQDSSAQGFTADLQMEGRRGRFSTVRLCTERSTGRPFAAKVIPYTEET KEATLLEYQILKKLHHTNVVQLHAAYLSPQNLVLILELCEGRQLLQCLSAGASYSELDVR DYLWQILSAVEFLHDKQILHLDLRSENILVTEHKLLKILDFGEAQYYFPDRVITPRRYMD FIETTAPELLEGQGVIPPTDIWAVGITAFIMLSAELPFSCDPGPEIKKGLVRFGRCYAGL SGGAVRFLQSALWANPWGRPSASDCLKMPWLQEAGLATLQEPPVIFPSTKLRHFLLERRK RAEEARRAAAQKIQ NT seq 31005 nt NT seq  +upstreamnt  +downstreamnt atggattccagctcattcagcggtgtgcctcgcttcctcacgaggcccaacgccttcatg atgtctgtgggtaaagatgccaccttgagttgtcagattgttggtaatcctgcacctgca gtcacctgggagaaggacaaacttcaaatccagtctggaggtcgcttcaagatggtacaa gatggcgaactctaccagctgaccatctacgacttatcctttcaggacagcggtcagtac atctgccgtgctatcaacaacataggcgaggcattcgctgcggtcacagtcaaggtggga gagacgagtgcggtggtggaatgtgctccatactttattctgaagccaacttcctcgaga gtgagcctgggagaagacactaccttccagtgccgggtacaaggccacccatcaccagtg gtaacctgggagaaagatgatcgactgctgggaacagccgttgattccaaccgcttacgt gtagagtcccaaggggagtccagcgctctgcggatccactgtattcgcttttcagatagc gggacttatctgtgtcgagcagagaactctgttggccagatcaaggcttctgcttcactg tctattgagtcttttagcaatgtgaataccaacaatactggcgcaatggagtcttcatat ggtaaaacggcctcgctgctgtctcacctccagaaacggcgtgaggagatgcggaaaact gacctttccatcatgggctcctacgacttgaacaccacgagctatggagctctggatacc ttgactggtctgggattatctcttgactatgaaagggcggccacccttgcacccaaaata aaccgtgaaggtgccatgagcgtcctcacccgcacctgcactgtgactgagggcaagcac gccaagatgagctgctttgtaacaggtgaacccaaaccggagattgtgtggaagaaggac ggagaggtgatcacggagggccggagacacgtggtctacgaggatgagcaggagaatttt gtgctgaaaattttattttgcaaacaaagtgacaatggattgtacacgtgcacggcatcc aacctagccggccagacctacagctctgtgttggtcatagtcaaagagcccagaattcct ttccgatcaaaactacaagacctggaagtgagggagaaggaggcggccaccttccagtgt gaggttccacaaaccatcaccgaatccacctggtacaaggaggagaccaaactccagcag agctctaagtataacatggaagcagaaggaacgattcggagactgaccattcagaacatc accactgatgatgacgctgtctacatctgtgagatgaaagaaggcagccgcaccatcgct gagctgtccgtccaaggtaacctaataaagaagcttcctcgcaggacggcagtaccggtc agtgacacggccatcttctgtgtagagctggacaatgattgtgagaaggtcaggtggaca agcaatggtcagagtgtggtccctgacgggcggatctccattacctcctctggtaaacag cacaccatgatcatccgcgagtgcaagaacagcgactctggcgagattgccttcatagcc gatgagtgtaagacgtccacccaattcaccgtcaccaccttaagaaaacctccctctaat gcccccattaaccctgtggtgacagacaagactgaaacatctgtcagattagcctggtcc cctcccccaatggacaggccagtgcccattgatgggtacattgtagaacggaaaaaactt ggagccatgacctgggtgaggtgccatgaatcccccaacgtgcccaccccagagttcatc gtcaggcatgtcccagatgaaggaagcttccagttccgggtcagtgccttgaacagctat ggacagagcccccacctggagttcccggggacattatatctcgaaccggttccttccatt aagactcctctgaagccggttgacgttgcgtttggcgcagaggccactttctccgttgac ctcaccacggtgtctcctggctcgtggtggataaacgggaaggttgtggagagtaacgat cagtatgtggtgaaacgggtgaagaacacgcacatgcttctgatcaagagcgtcacccaa caagaggaccaagcagatattacattcacctgtaaaggtatcgagagcagcaccaagctg agggtgagagctcttccacacttcacaaccagtaagaggctctctgaggtgcagctgagg tctggagatcaggcagagttcgtgtcggagacttcggaggagaacgtccgggttttgtgg tataaaaacggcaaagagattcgacactcgaagaaattccagctggagtcccgaggaaaa ctccagaagctgcagatctcctgcgtccagagggaagatgaagggacgtacacgtgcagc ctaggcgatgacatcatcaccttcagcttacaggttacagaaccagagccggccttcatc aaccaggacaaggtccagaaggaggtggtggccaaactgacggagagcgccgtcctgagc tgtgaggtctccgagagaaagacggaggtgaaatggtacaaggacgggaagctgatcacc tccagcaagaaactgagggtggagaccgagggcaaataccggcgtctggtggtggagcag gtggagaagaaagacgccggagagtacagctgtgaggtggccgggcagaagatcagcttc aaagtcaacgtcaaagaaccagagccggccttcatcaaccaggacaaggtccagaaggag aaggtggccaaactgacggagagcgccgtcctgagctgtgaggtctctgatggaaagacg gaggtgaaatggtacaaggacgggaagctgatcacctccagcaagaaactgagggtggag accgagggcaaataccggcgtctggtggtggagcaggtggagaagaaagacgccggagag tacagctgtgaggtggccgggcagaagatcagcttcaaagtcaacgtcaaagaaccagag ccggccttcatcaaccaggacaaggtccagaaggaggtggtggccaaactgacggagagc gccgtcctgagctgtgaggtctccgagagaaagacggaggtgaaatggtacaaggacggg aagctgatcacctccagcaagaaactgaggatggagaccgagggcaaataccggcgtctg gtggtggagcaggtggagaagaaagacgccggagagtacagctgtgaggtggccgggcag aagatcagcttcaaagtcaacgtcaaagaaccagagccggccttcatcaaccaggacaag gtccagaaggaggtggtggccaaactgacggagagtgccgtcctgagctgtgaggtctct gatggaaagacagaggtgaaatggtacaaggacgggaagctgatcacctccagcaagaaa ctgagggtggagaccgagggcaaataccggcgtctggtggtggagcaggtggagaagaaa gacgccggagagtacagctgtgaggtggccggacagaagatcagcttcaaagtcaacgtc aaagaaccagagccggccttcatcaaccaggacaaggtccagaaggaggtggtggccaaa ctgacggagagcgccgtcctgagctgtgaggtctctgatgaaaagatggaggtgaaatgg tacaaggacgagaagctgatcacctccagcaagaaactgaggatagagaccgagggcaaa taccggcgtctggtggtggagcaggtggagaagaaagacgccggagagtatagctgtgat gtggccgggcagaagatcagcttcaaagtcaacgtcaaagaaccagagccggccttcatc aaccaggacaaggtccagaaggaggtggtggccaaactgacggagagtgccgtcctgagc tgtgaggtctctgatggaaagacggaggtgaaatggtacaaggacgggaagctgatcacc tccagcaagaaactgagggtagagactgagggcaaataccggcgtctggtggtggagcag gtggagaagaaagacgccggagagtacagctgtgaggtggccgggcagaagatcagcttc aaagtcaacgtcaaagaaccagagccggccttcatcaaccaggacaaggtccagaaggag gtggtggccaaactgacggagagcgccgccctgagctgtgaggtctctgatggaaagacg gaggtgaaatggtacaaggacgggaagctgatcacctccagcaagaaactgagggtagag accgagggcaaataccggcgtctggtggtggagcaggtggagaagaaagacgccggagag tacagctgtgaggtggccggacagaagatcagcttcaaagtcaacgtcaaagaaccagag ccggccttcgtcaaccaggacaaggtccagaaggaggtggtggccaaactgacggagagc gccgtcctgagctgtgaggtctctgatggaaagacggaggtgaaatggtacaaggacggg aagctgatcacctccagcaagaaactgagggtagagactgagggcaaataccggcgtctg gtggtggagcaggtggagaagaaagacgccggagagtacagctgtgaggtggccgggcag aagatcagctttaaagtcaacgtcaaagaaccagagccggccttcatcaaccaggacaag gtccagaaggaggtggtggccaaactgacggagagtgccgtcctgagctgtgaggtctct gatggaaagacggaggtgaaatggtacaaggacgggaagctgatcacctccagcaagaaa ctgagggtagagactgagggcaaataccggcgtctggtggtggagcaggtggagaagaaa gacgccggagagtacagctgtgaggtggccgggcagaagatcagcttcaaagtcaacgtc aaagaaccagagccggccttcatcaaccaggacaaggtccagaaggaggtggtggcaaaa ctgacggagagtgccgtcctgagctgtgaggtctctgatggaaagacggaggtgaaatgg tacaaggacgggaagctgatcacctccagcaagaaactgagggtggagaccgagggcaaa taccggcgtctggtggtggagcaggtggagaagaaagacgccggagagtatagctgtgag gtggccgggcagaagatcagcttcaaagtcaacgtcaaagaaccagagccggccttcatc aaccaggacaaggtccagaaggaggtggtggccaaactgacggagagcgccgtcctgagc tgtgaggtctctgatggaaagacggaggtgaaatggtacaaggacgggaagctgatcacc tccagcaagaaactgagggtggagaccgagggcaaataccggcgtctggtggtggagcag gtggagaagaaagaggccggagagtatagctgtgaggtggccgggcagaagatcagcttc aaagtcagcgtcaaagaaccagagccgaccttcatcaaccaggacaaggtccagaaggag gtggtggccaaactgacggagagcgccgtcctgagctgtgaggtctctgatggaaagacg gaggtgaaatggtacaaggacgggaagctgatcacctccagcaagaaactgaggatagag accgagggcaaataccgacgtctggtggtggagcaggtggagaagaaagacgccggagag tacagctgtgaggtggccggacagaagatcagcttcaaagtcaacgtcaaagaaccagag ccggccttcatcaaccaggacaaggtccagaaggaggtggtggccgaactgacggagagc gccgtcctgagctgtgaggtctctgatgtgaagacagaggtgaaatggtacaaggacggg aagctgatcacctccagcaagaaactgaggatagagaccgagggcaaataccggcgtctg gtggtggagcaggtggagaagaaagacgccggagagtacagctgtgaggtggccgggcag aagatcagcttcaaagtcaacgtcaaagaaccagagccggccttcatcaaccaggacaag gtccagaaggaggtggtggcaaaactgacggagagcgccgtcctgagctgtgaggtctct gatggaaagacggaggtgaaatggtacaaggacgggaagctgatcacctccagcaagaaa ctgaggatagagactgagggcaaataccggcgtctggtggtggagcaggtggagaagaaa gacgccggagagtacagctgtgaggtggccgggcagaagatcagcttcaaagtcaacgtc aaagaaccagagctggccttcatcaatcaggaaaaggtccagaaggatgtggtggccaaa ctgacggagagcgccgtcctgagctgtgaggtctctgatgtgaagacggaggtgaaatgg tacaaggacgggaagctgatcacctccagcaagaaactgagggtagagaccgagggcaaa taccggcgtctggtggtggagcaggtggagaagaaagacgccggagagtacagctgtgag gtggccgggcagaagatcagcttcaaagtcaacgtcaaagagccggaactggccttcatc cacacggataagatccagaaggaggtggtggtcaaactgacggagagtgccaccctgagc tgtgaggtctctgatgtgaaaacagaggtgaaatggtacaaggacgggaagctgatcacc tccagcaagaaactgagggtggagaccgagggcaaataccggcgtctggtggtggagcag atggagaagaaagacgccggagagtacagctgtgaggtagccggacagaagatcaacttt aagatcaatgtcacagaaccagaagccaagttcctgaagacgtctgaacagaaagaagca gtatttgtacaagagcacgaggacatcaccctgctgacctctgtccaaccccaaaatgct caagtcaaatggtttaaagatggcactgagctgagtgcttccaaaaagtaccagatatct gcagatggtgcgtccaggacccttattgtgaaaacagcagaaagcaaagacagtgctgtg tacacctgcagcattggtagtgataagcaggagttccgggtacaagtcaaagaaatccct gtgaagtttgtgaagaagttggaggccatgacaggagagatcggctcatccatcacacta acttgtgagctgagccaggccaaaggcgatgtgacctggaaaagaaatggaggggagatc aaaccaaacaagagaatccagatccgctcagatggaggcaaacgtagcctgacaatctcc cagctgaaggccgaggatgaaggggagtattcttgtgaatcacgggataagacaaccatt gcacagctgagaaccaaagctccacgagtcgttaaattcaccgcagagctgagtaacgtg gtggtggaggaaggtgcagaggccacatttaaatgcaccatatccccggatgacgctgca gtgacctggtatagaaatggtgccaatatagaaaaaagcaataaatacaagttcagtaag aaaggagccatccacagtttgagcatcagccagctgaccctgcaggatgctggggaaatt actgcagatgcagaaggggtgaaaaccacagccaccctgaaggtccgagaggccccagtg ttgtttaagaagaagttggaagctatcacggtagaagaaagacatactgtctgcctggag gtcgagctctccaaagccaccaaagacgtgaaatggatgaagaacggcgttgttcttcag tctggtaacaacattgaaatcaaatctgaaggctgcaagcagatcctcatcctaaagaac gtcacatataccgaccgtggactgtatggctgtgagacgctggatgactccacacaagcc aagctcaacgtggagatgcggcaggtgaagctggtcagaggtctccgggacgtggaggtt cgtgagaaggactcggccacctttgagctggagctctcacatgaagatgttgatgggtca tggatgaaggatgggttgaagattaaatcctcagaatcctgcaagattatagtgaatggc agaaagcatggacttctcctgtcctctgtgaagcaggaagatgctggagttgtgtccttc aaatcagaaggaatccagagctccgctaaactcattgttaaagagcctccagtgacgatc actcatcccctccaggacatgacagtggaggagagggacaaggtcacctttgaatgtcag gtttcgagggcaaatgccgaggtgaaatggctgaaggatggatcggagctcaggccgagc aaaaagatcacaattatctcccaaggtaacaagcgtaacctcaccatccacaagtgcgaa cctgacgacaaaggggcgtacgtctgcgacgctggcgacaacaagagctccgcccatctg accgtgcaagctcgggacatccgcttcattaggccgctggaggacgtggatgtgaccgag aaggaggcagcttcattcatctgtcagatttctcacgatgacgtccaaactcaatggtac aaaaatggcgccaagttgagggcaggagacaacgtgaagatgcgccaggaaggacggacc ttctcactgaccttcaagagtgtccaggcgcaagatgccggagagatcaagcttgtcgct gaaaatgcagagtcctgcgccaggctgtgcattcgagagcttccagtaaaaataaccaag ccactgcgggataagatcgccatagagaagcaccgggcgttcctggagtgccaagtgtcc cgtgccagcggcgaggtgacctggtacaagaaggacaaagtcatacaaacgggaaagcga tacgagattgttagccaggagcgcgacaggaagcttatcatcaacgaggtggagttcgag gacgaggacacctacacctgtgacgccggagatgacaagacctccgccaagctgctggta gaagaacaatctattaacattgtcagtgagctgagtgatgtggaggtgatggaaccggag aaggcgacgtttgagtgtgtaacatccattgtgtctgtgaagcccccgaaatggatcctg gggggtgaagttctacaggatgggaaagacctcaccatagagcaggaggggacggtgcat cggctgaccctttggaagacatcctcaaagatgagcggtgccatccagtttcacattggg aagtccaagtccaccgctcatctggttgtgacagagattccagtgcaggtcactcagaag ctagaagacaggacggtcagcgagcgccagtctgtcctcttctcctgtgagttcaagcct cctcctaagtttgtggaatggttctgggggaagacgcagatcgaagcttcagacagatac agaataaagcaggagcgcggcacagcagagctgaggattgtgaaggtgactcctgaggat ggtggcatatacacgtgtaaagtcgggccagtcgagacttctgccatactcacggttcaa gctcgggacgtaaaagtgttgaagcccttggcagatgtggaggtggaggaagagagttgt gctgcattctcctgcgagctgtctcatgatgacgaggaggtggaatggttcctcaatgac acgctgctctacacaaacaactacaatgacatcaaaaagattggagaatgccacaccctg accctgaagcaagtggctgctcaggactccgggaccatcagcctaaagactcagaagctg acactcactgcagagctgaaggtcaaagagaagcctgtagtgttcatgaagtctctggat gatgcggtgggagaggagcgagggatggtcactctgaagtgtgaggtctccaaacccaaa gtcaccgccatctggaagaaaaatgatcaacttctgccaaacggagacaaatatcaccag atccaggctggaaaaatcgtgtcccttaccatccacaacctgaacaaggccgacgccgga ctgtacacctgtgacatcggcactgaagtggcaaagtcgaaagtcagcgtacaagaactc aacattggaatcacgaaacgcctgaagagcaccgaggccaaagaaggtgagagctgcagc ttcgagtgtgtcttgtctcatgagagcatcgatgaatgctcctggacggtaaacggggtg gacgtagaaagtgatcagaggttcgaagtgtccaacaagggccggaagtacctgctgaac ataaaggaggtaaaggccagtgacgccggagatgtgatcttcacagctcgcaacctatca tccaaagccacactgactgtcagagagaagccagcaataatatcaaaacccctggaagat aaaacttccattgctggagaagacattgtgctgaaatgtgagctctcaaaggaggacaca aatgtcaagtggtccaaggatgggaaagtgctgaggagaaaccagaaatatgaaatctgc caggagagaacggagacctggatcataattcatgaagcctcagtcaaagactctggtgaa tacatctgtgaaacttccatctccaagacaaaagcttcagtgcagattgcagaaaaaccc aatagattcattaaggagatttcagacgtgaaggccgaggagggggaagctgccatcttt acctgtgaggctgagagaagtccacccaccgtgaagtggaggaaaagtatcactgagctc aagtcgtccaagaaatatgagctcagccagaaagggaatgtcctgagcctgaccgtcaac gacctggagaagggcgacagcgacacatacatatgtgatatcggagatgcccagtgcaag gcctccctcactgtcacaggccacaaagttcttatcgtagaagacttggaagatgcagaa gtttttgaaggagaatctgtcatgtttaagtgtaggatttctccggcacattatcagaaa gtacaatggtttctggataaaaccccgttgcataccaatgaagtcaatgagatacaagcc cttgcagggggctaccacactctgtatctcaagcagttgggtgtgaaggactctgggata gtcacctttgaagccgggaaccagaaaacttctgtaaaacttttagtgaaagctgttcag gctttcttcaagcgtgaggtgcagggcacggaggccgaggaaggcgcagcggccacactc tcctgtgaactctccaatgagaaagctgctgtgcagtggaagaaggatggagaactcctt cagcccagcaataagtatgagatgaagattagagatcgcagagtggaattacttgttcac aatctggtgaaggaagatgccggaacgtatacatgtgaaaccggggaacagacgtcttcg gcaatgctaaccgtcagggctgtccaggtcttatttaaaagaggtctccgtaatgagaaa tccaaggaggggagcacagtcaaactacaatgtgagctcaataagtctggtgcgcctgtg acatggactaaagacgaagaaatattacagagtggtgacaagtatgacatcaagcaacag agcgctgtggtggagcttcttatccttaatgcaaaaccagaagactctggtgactacacg tgtgatactggagaccagaagagcacatctcatgtgaccatcactgctattccagttcgc tttaaacaagacctgcaggactgtaatgtggacgaaggttcttctgtcactcttgcctgt gagatcagtaaggccaacgctcatgtcatttggaagaaaggtgttaccgttcttcaagcc aatgacaagtatgaatttaggcagaagggaactgtagtagaactggtcattcacaatgtg aaatcagaggattcttcaacctacatctgtgatactggagaccaacagactactgcccgg gtcaaagtgcaagaacttccagcccacttcaccgaggagctgatcaatcagcaagctaat gaaggagcctccatcactctacgctgtgaactcaacaagccagatgcccccgtagagtgg aggaaggagaacacagtgatcaaaccaagcaagaagtttaagatccaccaggagggtcag accgcagaactgatcatccgtgacctggcaccagaggatggaggagactacacctgcatc tgtggagagcaccaggcgactggaactgtgaaagttactgcgttacctccactgtttaaa gaagaactaaagaatgaaagggcatctgaaggagaagatgcaaagctcctctgtgagctc accaaacctggggccaccatagaatggagaaaaggggaccaggtccttaaagctggtgac aaatacacaatgaggcaggaaggagtgtatgccgagatggtaataaaaaatcttgacaac agtgactctgggcattacacctgcgtgtgtggagagcagaagaccacggccgtgctgact gtcaatgctcttccgatactcttcaaagaaaagctcactaacactgaggcagtggaagga gaaactatcactctccactgtgagctctctaagccagtgtcctctgttgcatggaagaag ggacacgccaccctgaaaccaaacaataagttcacaatgattctggaaggttctgtggcg gagttgaccattcaggatcttgatctgaaagatggtggaagctacagctgtgtttacgaa ggagaagagaccatggcgaacatcagagtcaatgaacatcccattctcttcaaacatgag ctgagtaacgtggagagtacagagggccgagccgtgactctgagctgtgaattcacccag cccccacctcatgtggaatggagaagagggcacaaagtcatcaaaccaggacagaaatat gaagtgaggcaggatcgagcaaccgcgcagctcatcattcgggatttagagcagaaggac accggagattatacgtgtgtgtgcggggagcggtgctccacagccgtcctaatagtgaat gctcttccagtacatttcacacacggcctgaaggacgaagacaccgcagagggtgagaga cttgtccttcattgtgaactcagcaaacctgacgtaagcgtagagtggagaaagggacgt actctccttcaggagtctgagaaatacgtcctgagacaggagggccccgtggtggagctt gtcatcactgacctacgtgaggaggatgctggaatctatagttgtgtctgtggagaccaa gaaacctcttcaaccatacatatcaaagctttacctccaagatttacgagagaactcaag agcgaggattgtacggaggggagctcagctcttctaacctgtgaactgaccaaagccaat gcccaactagagtggaggaaaggagaccatgtgctccaacccagcaacaagtacaagatg acccaggatggctgtactgccgagctggagatctctaatgtggacttgcacgatggcgga cagtatacgtgcatgtgtggagaccaaaagacctcggcaacactcatagtgcatgcttta ccaccagaatttaaggaagaactaaaaaatcaggaagctgtagaaggcgactcggtcact ctgcactgtgagctgaccaaaccagacgcatctctggagtggagaaaaggacacaaaatc attaagtccagtgacaagtacagtgtcatccaggaaggtttggtggctgaactggttgta cgcaacgtggaccaacatgatactgggagatatatttgcgtgtgtggagataatcagacg gcagccacactgaccgtgaaggctattccaccacaatttaaagatggattagacaacacg gaaggtgtggaaggagaatcgctgaccttacgatgcaccttgaccaagccaaaggcttct ctgcagtggagaaaggagcaaaagacgctgaagccgagcagcaaatataaatttgtccag aacggtcttgtggctgagctggtcattcattgcctggatctagacgatgctggggaatac agatgcatttgtggggaccacgaaacatcagcttcagtggccgtgaaggctctcccacca cggtttagaaaggaattaaagggcaaagaaatctctgagggaacgtctgtcactttatgc tgtgaggtaaccacatccaaagcccttctagagtggaggaaaggacggaaggtactccag gccagcaacaagtacagattcatccaggaaggtcccactgctgcgatggtcattgataat gcggatgtgaatgattccggggagtatacatgtatatgtggagaccatcggaccacagct tccctcactgtcattgctcttcccccacaatttatggaagtattgaaggacaaggaaggt gtcgaaggagagtctgtgactttagactgcatcatgaccaaaccgaaggccactctggag tggagaagaggaaagaagatgcttacccctggagacaagtatacattcatccaggaaggt ctttctgccgagctggtcatcagccacctggaccctgaagatgcaggggagtacacgtgt gtgtgtggagaccagcagaccactgcaaccctgaatgtgaaggcacttcctccactattt aaagaagaactgaggaacaaggaaggtgtcgaaggagaatctgtctccttacaatgtgtc ctgaccaaaccgatggctcctctggagtggagaaaaggacagaagactcttacccctgga gacaaatatagattcatccaggatgttcttattgctgagctggtcatcagtcacctggac cctgaagatgcgggggagtacacatgtttgtgtggagaccagcagaccactgcaaccttg accatgaaggcactccccattgttttcttggaagaactgagaaacgagatgttgagcgag ggccagaatgctactttacgctgtgagctgagtaagcccggtctgccggtgtcatggaag aagaacaactctgtgattacagctagtgacaaatatgccatgtgccaggatggtcctgtc tacgagctgacaatccacaacctgcagctggaagacaccgggacctacacctgcctttat ggagagcagcagagcacagccatgttatcagtgcaggagttaccggtattattcatggaa ggattgaaaaacattgatgtcttggagtgcggagaagccgtcttccagtgccaggtcacc aagccaaatgcacgactgcaatggaagaaaagtcagaagacgttacaaccaaatgataag tataagattcggcaacaaggagtgaatgcagaattggtcatccgagatgttaacctgaag gattctggaaactatacctgtgtaattggagaggaggcgactacggcaacgttaacggtc ttcgagttgccggcacattttagctctgaattaaccaacctggaagttatggaacgagga accgctgtcctgcgctgtgaggtgacaaagccatcggccgcagtacagtggaagaaagga gagaagacaatacgactcagcgataagtacgacatcaggcaagacggcactagattagaa ctccagataaatgatgtagagctgtctgatgccgatcagtacagctgtgtctgtgaaaag cagaggacaacggcttccctaaccgtcattgctctaccggcggtcttcaccgagcagctg aaagatctacaagtgtcagaaagtgacacggtgaccttacattgtgagcttaataaattt ggcctcacggtagagtggaggaagggagatgtcaccctgacacctggagaccgaactatc atgaagcaggaaggacgagctcatgacctcctcatcagggatgttactgtgaaggattct ggggaatattcctgcctgtgcgagggtgtcacatcctcagcgcttctttctgtgaatgct cttccagtgctgtttaaagaggaactgaaaaaagttgacgttctggaaggagaaaatgtc accctgagctgcgagctgaacaaagtggacgtgtgcgtggagtggttaaagggcgacaag agcttacaacctggaggcaggtatacagtgcagcaggtcgggggcactgctacactcagc atcctggaggtcagagaggaagatgatggggattatacttgtgtctgtggagatgcaaag agcattggccacctgcacgtacaagctttacctgtgctcttcacccggcccctccagaac gttgacgcccaggaggagcacacagtcaccctgcaatgtcaggtatccaaggccggggct gcagtagaatggaggagagcagggttaggattacaagcagggagcaagtatgaaatgcag cagaaaggaaatgtgagggagctgctgatccaccacctgaggctggaggacactggagaa tacacctgtgattccggagaccaggagaccaaggcctatctgacagtcacagccctcccc gttgtgtttgtgaagcctctgaagaacactgtggtagaagatggggtgaccgtgaccctg cgctgtgagacctctaaggccaatgtgccagtggaatggaggaagggaacggtgggaatc ttcccttgcgccaaatatgaaatgaaacaagaaggagcagtgtctgagttggtcatctat gatgctgaagctgaagatgctgcagagtacacgtgtgacaccggagaccagcagacctca tgcactgtcaaagtgaatgtcctccagtttgtgaagagtttgcagagtgttgaggaagag caggggggcagcgtttatctccactgtgaggtctctgccaaaatggcctctgtggaatgg tggaaaggaagcgagaagctacagcccaacaacaagtacgagatgcggcaagatggcacc atgcgggatttaattatccacaacctggagctggaggatgctggagaatacatgtgtact gcccggagcaagaggacctcagcgagcctcagcgtcagagagttggacatcaccattgtt cgtggtctgacggacctgtctgtgtttgttggtgaagacgccgtgttcaagtgtgaggtc tcccacgagaaggcccgggatgtggagtggaagctgcaggggatccttctggagaacaac cagatgaacaagatctcagtggagaaagagaaatcccatgtgctgaagctgagcggtgtc acccaggatgactcggggagcatcaccttcaggatgggcccatacgtgtctacagcggag ctgactgtgaaggcccttccggtggtttttgaacaaaagcctgaagaccagagttgtgag gaggggtctacagtcgttatacgggcgcagatctcaaaggccaacgttgaggcaaaatgg agaaggggaaccacggagatcatccccagtgagaagatcgatatcaggcaggacggtaaa accgtggagctggttatactaccggccgtgccggaggactctggagactacacgtgtgac accggcgatcaggaggtcacatgtaacttgcgtgtaacagcgctgcccgtgcagttcacc cgccacctgcagaacgtgcacggagaggagaacgggtctgtgacgctgagggcggacata tccaagcctgatgcccccatacagtggaagaaagccggtctgaccctaaaatcaggggcc aaatatgagatgaagcagtcgggctgtgtggtggagctctgcattcacaagctgcagcca tcagacgcaggagagtacagctgtgacaccggacacctgacatctgtggcgaatgtccac gtgaaagagccagagcctttcgttgtggaccagctgcagaacgtgtctgtggaggaagga gaggacgccatcttcaagtgtaaggtgtccaagaacaacgcccccgatgtgcagtggtac ctggccggagtccctctacagtccaatgagatgaatgagatagctgtccacaagggcaag attcacaccctgaccctaaagaaggtgtccctggaggacgccggccccgtcagcttcaga gtgggacagagcacgacagcagcagagctggaggtgaaagctctacctctaagattcacc aaacctctgcagccgacggaagtggatgagaaaggagaagtcgccctgcactgcgagctc tccaaacccgacatcactgcagaatggaggaaaggggccgccgtaatcagacctggagga aagtacgaaatcagcctgaaaggagccgcgcacaccttacatatcaaagatgtcacactg gaagattcaggggaatatagctgtcatgcggtaaacgagagaacatccgcaacattacaa gttaaagccctgccgcttgtctttacacaagagctgcataacattgagccggaggagggg aggacggccatcttacagtgcgaggtgtctcgggaaggtgcgcctgtggagtggaggaag ggggctgtggtcctacagtccgatgataagtatgagatgagacaggctgatcgtatagtt gaactgatgatccacaacgtggcaccggaggactgtggcccctacacctgcagcacagga tccgcccagaccacggcctctgtgtttgtacaagccggtaatgtagagatagtgtctggt ttaaagaacacagatgtctttgcgggggagatggccaccttctcctgcgagctgtccagc ccggatgtgcggaacgtacagtggtggctcgatggttctccactgcagaacagctcagtg aacgagatctccgtgcacagaggcagagtccacaccctaaccctaaaaaacctggggacc aatgactctggcgtagtcaccttcaaagccggctccctcatatctaccgctaaactctta attaaagatccaaccattgaagtggtcagtccaatgagtgacctcaccattgatgaagat gacacagcacagttcatctgccagtactctagaccagtgcaggctgcgtggaagaaacac gatgtagatctgtgcgccgatgggaagagggtcattgtcgagcaagactggaatgtggcc aagttgaccattaagtctgtggttcccgaagaccgaggcgtctatgtgtgtgaagctgga ggcactaggattgtcgccatgcttgatgttgaagagaagaataagatcctgcagggtctg gagaacgtggaggcgctggagggcggggaggcactgtttgagtgctacctctctaagccg gagtgctacaactacaactggctggtggatgacgaggcggccaagagctccgacaacgtg gagatggtttacttcgagaatggccgccggcatctgctgctgctgaagaacctgacggcg gaggacagctgccgagtcaccttcatggccggggacgccgtgacctccgccttcctgagt gtgcgaggctggcgtctggatgtcgtgaagccacctgctgacactgaagtggctgctggt gacaaggcagcgtttacctgtgtgctcagtgaagcggtgccggtaaatgaggtatcctgg tattttaatggtgcacccatccagcccgatgagaactggtccatgatcatggatgggaac cagtacaagcttctcctgaaagacgctcagacgcatcactccggggaggtggccttcgcc tccagagatgtcgttgtctctgccaaactgctcgttcttgcccttcccgatcccccagaa gaccctgagattgtcagtaagacgagcagctccttgaccttgtcttggttcacgccccgg agtgatggtggggctccgattgttggatataatgttgagatgaagtccccgggtggtgac tggcaacagtgcaacatggagattatacagagtatggagtatgtggtccaaaacctggag ccgggccagccctaccgattccgtatctcctccattaacaaactgggcagaggggaacca gttcacttaccgcagacggtgcagctagaacatccggtgatggttcatcatccgctacag cataaatctgccacaccaggggagacccttcgcctggaatgtgaactgtccaaggaaagt tgtgaggtcacctggatgaaggagaatgaaccactgaatccagggaagaaataccagatt atttgtgaggaaaagagacagatcctgctcatccatgatgtctctgctgatgaccaagca acctactcctgtgtcacctcctctggtgacaagacttctgccaccatttctttgggtata caaaccattacggagctggtaactgtacaggaggctcttggtttgacccatgtaaggacg gatcatgtggttgaggcagaagacagcacacagcccaaccttcccccagaggctgctcaa gaaggagatcttcatctgttatgggaagcattggccaaaaagaggaggatgagcaaggag cccaccttagactccatctccgaggtcccagaagaagatgaaaaacggaagcttaaaaaa gaggctgagcgtcgagcagatttttcaggttacacttctgaagacgtggccaagacaagt gaggccgacttctctcttacaagttctgatgacgagtcccgggctgggacaccatctctg gtctcatatcttaagaaggccggtaagtccaccatcacctatggaagtaaggtccagaca gtgtctgccagcaagtttttcaagcacttcgagacctcaaatatcactgaagtgaaggaa ccagtaaaagaaccagacttgtcggaaatatttgacgatgacccagccctggacaaggca gctgtcaagattcaggcagctttcaagggctataaggcaagaaaggtgataaagcaacag gagtgtcccatgtttactgagaccttcaaagacctctcagtggagcctggaggtacagtt caccttgagtgtgtggccatcagtaagagtgacatcaccgctcaatggatgaaggatggg aaggagctgtctgatggtcgtcactaccacatcgataattaccctgatgggacctgctcc ctaattatcactgcagtggagctccaggacacaggcaattacacatgtgaagcttccaac aaatttggtcaggtgtgccacagtgcaaagctggtggtggatggtggggaaccagagatt cctcaaaagcccatccccatcccaccaaaatcatccacagatagtgagactgaaacttct ggaagtgacttggatgatgctttccggaaggcgggaaggaggctccataaaatctttaag tctaggtcttccctggaaatgtctgaagaagagctgtttgtcagcgctgatgagggggat ctgcctcccatcgaccatcagacctaccgagaagatgacaagttcatctacatcaagttt gaagtcatgtcagaagcttcagtcgccgcacacaggttccgtgagatgttctccgcgatg ggaatcaaagtgaagatcgacatcctggagcaagggcagaagaacatcgagctacgcata atgaaagtggaaacaggacccacagagcaacagaaactgcaagccaagcaacagatgacc ttactcacctcagacacagcccctgtcttcatcacggagctccagaaccaggaggtggcg gacggttacccggtcagctttgattgcgttgtgattgggaaaccgatgccgagcgtccgc tggttcaaagacgggaaagcaatagaagaagatgaccattatatgatcaatgaggaccag gagggctgccaccagctgatcatcaccgccgtggtgctcccagacatgggggtctacagg tgtctggcggagaacaggatgggagtggcctcgactaaggcggagctgagggtggacttg accagttctgactacgacacagcggaggccacagagacctcgtcctacttcagcgcccag ggatatgcatccagagagcaggagagcctggagtcggccacggagcaggagcagctgccg caggtcctggaggagctccgcgatgtcctggtggcccctgagaccccaatcgccaggttc cagatcagagtgaaagggtttcctcgcccgcgggtccactggtttaaggacgggcagccg ctccactcctcagaccggatactggtgaccagtaagaggaaggcacactccctggagatc ctgaacgtcagcagggaggacgccggcgagtactccacctacatcagtaactccgccggc tctgcctactcctccgccagactgacggtgaaaggtccaggagagctgcagaaagagaag tcagcagaggacgctggagatctgaagaagccagttcctccaatgttcctggagagattc acaaacaagaatgtgcagaagggcgccagcatcaccctgtctgtgaaagtggaagggatc ccagtccccatggtcacttggctgaaggaagagtctcctgagaacgttctgttgatcaaa ccggagaccccgggctacaagctggcgagctccaacatgcaccacagcctggtcctgctg gacgtgggcactgactacactgcaacctacacctgcatcgccaccaacaaggtgggacag tccatctgcagcgccaccgtccaggtcctagaagaaaaggaggcgcagattctggcaaaa gctgataagattgtgaaggacattctggggtcatctgtgccgggaaggatcgggacgtcg gtgcagccggcggaggcagatggtgactcccgaatggcacagaagacgcacatctcatta acagaggtcggaacggaggagttcttccagaaactgacgtcacagatcacagaaatggtc tctgcgaagatcagtcaagcagcttccctccgagtacccacaatgcccggcatggacagc gacgatgagtccaagactccatcagcctccccgcggcacggcagatccagaccgtcatcc attgctgtcgagtcatcatcagagtccgaggatggagactccagaggagagatcttcgac atctacatggtgacggcagattacagccccataacagccgataaggagacaatcaccctg aaggaggggcagtacgtggaggtgctggactccgctcatcccctcaagtggctcgtccga acaaaacccaccaaattcagtgcctcccggcagggctgggtgtcccctgcgtatctggac aaacggctgaagttgtccccagaatggggagcaggagacgtggtggagcaccccggggag accgtctctgaggaggagtacaagaagaggctcagcacaatcatccaggatcttctgagc tcggagaaggaatacgtcaccgacctgcagttccttcagacccatcacctgagttacacc gagagctgcacagatgtccccgaggctgtggccatccagaagccagtgatcttccggaac atcagcgacatcgggaacttccacgccagaacgttcttccaggaactgaagaagagcgac acagacgacgatatcgccatgtgcttcatccggaacgaggaggaattcaacaagtacatc atgtacctggtgggccgcgtgcaggccgagtccgtggtggtcaacgacgccattcaggag ttctacaagggatacgcggaggatatcctcgctctgtcggacccctccagacccccggcg cctcctctccaacattacctggagcggccgataagtaggatccatcactaccaggtcatc ctgaaggaaatgatccggaacaaggcccgaaacagcaagaactgtgcgctgctggagcag gcctacgccatcgtgtccgcgctcacccgccgggcggagaacttcctgcatgtgtcactg atggagaattaccctgggacgctggaggcgctaggagagcccatacgacagggccacttc attgtctgggaaggagctccaggggcccgaatggcctggaagggacacaaccgccacgtc ttcctgttcaagaattatgtcatcatctgtaaacccaagagagacaccaggacggacacc tacagctacgtcttcaagaacatgatgaagctgacaaacattgacgtgaatgatcaggtg gagggcgatgaccgcgccttcgagatctggcacgagcgcgaggactcggtgcggaaatat ctgctgcaggcgcggacggtgatcatcaagaactcctgggtgaaggagatcagcggcatc cagcagcgcttcagcctcccgctctggaatccccctcacttcatcgaggtgctggcagat tgtacggccgagctgggagaaaccgtcaaactggcgtgccgcgtcaccgggaccccgaaa cccacagtcacctggtacaaagacggccgcccagtggaggtggatccgcatcacatcatc atcgaggatccggacggctcctgcaccctcatcctggacaatatgaccggggccgactcc ggccagtacatgtgcttcgcctgcagcccggccggaaccgccagcacactgggcaagatc ctggtccaagttcccccgagattcatcaacaagatgcggaacgtgtactttgtggaagga gaagatgtgcagctctcatgtgttattgaaggggcgccgtacccacagatcaggtggtac agggacagtcatctgctgccggattccagtaaacaccagacgtttgccgagccgcggagc ggagtcctggtcctggtgataaagaacgcaaccaaggacgacgtggggcactacgagtgt gagatggcgaacagactggggtctacgcggagcggagcggaacttaacgtacaaaccgcg gccatgatggagcggagaggcgaccagaccgtcactatcgaaggagacggggctttgttg gatgcttctatccgggcttctttacaacgtgcagaccaggagatcagacaagtcctgaag aagctgatggcccctgaatcgggggtcaccacggcccaggatccccccccaacaaatacc gaaacggcaaaaagtgcggaacacagtgtcctcgaggatgggcgggaaacggcggacata ttcagagacgccaacacccagacgcccgaacaagccactcatgatgaagcccggaaggca ccagttgtcagtgaggccacagaagcttatcctgaggtcagttcttcagaaacccagaca gagccggacgtccctgagagaatcatcccaatcaggcttcagatggatgcagcggagcgg atgagacccccgggggcccagatctgggatgtccacagagaagtctacatccagaccaca cagaagacctgccggcatgtgagcccggagcgggaggcccgccccccgtacatgcaggtg accatagaggatgtgcacacccaacagggagaaactgcccaatttgatgccgtgatagat gggagcccccctctgaccataacgtggtacaaggacaacaactttttggtggaaagtgac agaaaccggttgatgcgagaggacaggaaatattccctcatcatccacagaacggaggct ggagatggcggggtgtacacctgtgtcgcccacaactctgccggagaagtgtcctgtaag gccgagctggttctgcatccagatgagaaggaacaggagacaaagccgcaacacaagagg aggaagctccagtctttctttgaggttaaagaagagattgggaggggatcctttggtttt gtgaaaagggttgtgcacaaaggaaacggagccacatgtgcagccaaattcatcccgctg aagagcaaaacccggcagcaatcgtatcgcgaaagggatatcatatcggaggtgtcacat gatcgggttaccctgctgctcgattcctttgaaaccaaaaagacattaattctcatcctg gagatatgttgcggggaggaactgctggatcgactcttccggaaacacatgatcactgag aaagaggtgaagatttacatccggcagctgcttgaggccatcgcttatctccacgacaag aacattctgcacctggacatcaagccgtcgaacatactgatggttcacgctgatcgggac gatatcaaactctgcgattttggatttgcacagaggattattgcttctgaatttcagtac agcaagtacggatctccggagtttgtggccccagaaattgcctcccaggccccagtgtgt aaagcgtctgatatctggccggtgggggtcatcagctacttgtgtctggtcagcgcctcc ccgtttgccgctcagaatgacagagagacgctgcggaacgtccaacaagggaagatcaac tggagctgcccgtccttcacccggctgagcgccgacgccaggcacttcatgatggccgcc gtccacatgtctccagacgcccggcccagcgcccgcgactgtatccaccacaagtggttt acggcgagctcaggcccagaggacattcaaccgatcagctccaaaaacctcaggttcctt gtggcgcgcagtcggtggcagcgctcgctaatgtgttataaatccatcctagtgatgagg tccattcctgagcttctgaatagcaagctggagagtacatcactgggcatcccccgacac ttggtggaatgcagcagctcgtcctccagtagtggctcgtcttctgataatgagagtgac attagtcctaccgcaaaagactgcaatccttctctcgagctgcacttgtccattttcaaa atgtctgaaaaggacacactgcaaaagtgtaacacatcagaatctggaattgaccgggaa gataacgaagacaagaagatggaaaatccagatacctctccaatgactagacacaagcgt gaacatgagagtgttgttggctcaaataaaagccaaagggaactggaggatgacaagaaa atgctggttcactctgtggcgacatctccaggaaggcgccttaagtacagagctgccacc attgaagttgggggcctcgcctctaaaaagccaaagactggatcttttattagggggact tctgcagacagtgctctgttgcttcagagagcaggtgacaaaccatcgttagcctgtgtg ccgaggcaaagtatcatcaatagcacattctacaaccagggttctgaaggacctggcatg gcaccacaagatgggtcactgaaagacaaagacttcatcaagcaccgggagcgggcacgc aggagtttgatgaaggctggatattctcaaaaaattttgagtggtttgcgagaaccactt ctggagcagttcacgatagaacaaagaatgttgtccgaccaagatgcacagctcagctcc cttaagaaatcggcttcatttgacacggcaaagagtgccttaaggtcctcgttcaaagtt tcaagcagaagccgttcccttgatgattacaaatcaagacccttgagcatctataaagga actgttgtggaagaaatagatcaagattctttgagagctgaacaaggaacatttaaaaag acagacactgacattaagcttcattctgacaactccataagacccatctcactacctcct gagattcatcaatattcagcaccagtaaagatgtcttcaacacaaagacctttgtctgca cccactacagatagggaaaacactattattgcagttttccatcagcatcctatactgcag accagcgtaagtagagaaagaccgtcatctgtacaaccaaaggtagaggaaagtaccgta atagcatatgtgataccaagacaaaccccagactcctcagcaatgaagaaaactggtaca gtgaaggctccacctcagtcttctcaacacagtatcaaggaccaaggtccatccttagac agtcaaggaggagtgacgtttacagtccatagcacttctgagggaaatgactttcttaca tctgatacttccacagaaggggatacatgcactgaactcttcatggtggacaagacaaag ggtgaagggtcaaaggttttcactgaacccaagacagaaaagttgtttcagtttgtagag ctgagcaatgatgacaacacaaggatgacagtgatatgtcaaggaaacattgaggaacat gtcacagctaatgaagaacctgacagaagtgcagggaatatgactgactctgtctctaca ccaatacaggtaggtacagccacaaaatcttcagaagatacaaccccccaagataccatt atggcagaggtcacagttgtccagcctgatgatggagacctgataaaaccacccatcaat cagacaatggacctccataaagatcacagtgaagaaaagtctccatttgaaacattagaa actatacaaaaaatggaactcccagcaggtggttgtgatgcatctcctcaggatgatgat gttggcagagattttcaatgtcctgtatatagcgctgcactagaggacttagttggagag atggcctctttgtcggatgagatggatgcgttggcgagtgaacaaaggccggttggccaa gaagttccttctcattttcccccagttgttccctctggattacaagatgtgggtccgggg gaatgccctgcaatggatatggaccccagccccgtggaggaaataacaaaggatctacag atgacatcggcttctcagtgtagcttttatgagtctctgtctcgggctgaggtctccacc attgagagccacagctccagtaagacatttatttctcattcggatagctctggcacaggg cggcgatctgacaatttctcagactttgatgaggcgggtagacgttcggaagtgtcactg gtggagattggtgaaatgcatcataagcagtcatccacaagtccagagcttcgccagttg gatgttgatgctgcttgttcccagctccatgatttttatgatatatgtacatctccccag acatctttgatgatagaggatcagaagtttaatttgtcttctccagcatctaagcatcca acagactgtggtgaaacagccatggaaacatcagtggtgttggggaagtccacgaaggat gggctaccactgcagccactgcagctgttggaccatcagcaaattacaactaaagacaga aaaacctcaaggaaacgaatcaaactcttccgacctcatagaaaatctgaaaaaaacgtg aaaaccccagaaataagtctgaagcagaaagtaaaagcctccgtggccaacatatcccgc atcatcaaacgaaaaccggggaatggaaaggaagcaggtccatcagagatgatgaagccc tcggtcactgatcatggagcagtcggtatcatctctggatcagtcaagaaaaaagggctt cctaccttcaaactgccgaacctcagtggcaaggacaaagctcctgcatttgtggaggag ctgacagaccagacagtggtcgtgggtcatctggtgacgttatcctgccggacggcgcag ccggtgacggatgtagagtggtataaagacggcattcccatccagagcagcgagcgcgtc ctcatatcgtccaccctgaagaactatcacctactcactatcctggtagtgaccatgcag gacctgggcatctacgcctgcgtggcctccaacgtgctgggaagtgcctccacctgctgt attataaagaaggccgagatcccgtgttgtcccagccgtccagaggtcgcccaggtgtac aaggacggagcgctgatcgtatggaaaccagtggagtccagcactccggtcacctacttc ctgcagtacagaaaggagggtgaggagtggcgggcactgactctggacatctcggattgc tgttactccacccgcagtctgtgtgagggtcacgtctactccttccgcatcgcctgtatc agtaaagcaggaatggggccgtacagcgagtcgtctgctgcagtgaggatcgggaggctg agcccagcacatggacagttatctggagctttggagcctcaggattcatcagcgcaagga ttcactgcggatttacagatggagggaaggagaggtcggttcagcaccgtgaggttgtgc acagagaggtcgacgggacgacccttcgctgccaaggtgatcccatacacggaggagact aaggaggcgacgctcctggagtatcagatcctgaagaagcttcatcacaccaacgtggtg cagctacacgcggcgtatctcagcccacagaacctggtgctcatcctggagctgtgcgag gggcggcagctgctgcaatgcctgtccgctggggcctcatactcagagctggacgtccgg gattacctctggcagatcctcagtgcggtggaattcctgcacgacaagcaaatcctgcac ctggacctgaggtccgaaaacatcctggtcaccgagcacaagctgctgaagatcctggac ttcggagaggcacagtactacttccctgacagagtgatcaccccccggagatacatggac ttcatagagacgactgctccggagctcctggaggggcagggggtgattcctcccaccgat atctgggcagtggggatcacagcgtttatcatgttgagtgcggagcttcccttcagctgt gatccagggccggagataaagaagggactggtcagatttggtcgctgctacgctgggttg tctggaggagccgtgcgttttctacagagcgcgttgtgggcaaatccctgggggcgcccc tctgcctctgactgtctgaagatgccgtggctgcaggaagctggactggccacgttacag gagccaccggtcatatttcccagcacaaaactaaggcacttcctacttgagaggaggaaa cgggcagaagaggcacggcgggcggcagcgcaaaagatccagtga

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