Buteo buteo (common buzzard): 142038127 Help Entry 142038127         CDS       T11399                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism bbut  Buteo buteo (common buzzard) Pathway bbut04020   Calcium signaling pathway bbut04260   Cardiac muscle contraction bbut04261   Adrenergic signaling in cardiomyocytes bbut04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:bbut00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     142038127 (RYR2)    04020 Calcium signaling pathway     142038127 (RYR2)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     142038127 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     142038127 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:bbut04040]     142038127 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:bbut04990]     142038127 (RYR2) Ion channels [BR:bbut04040]  Voltage-gated cation channels   Ryanodine receptor    142038127 (RYR2) Domain-containing proteins not elsewhere classified [BR:bbut04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    142038127 (RYR2) SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  142038127 NCBI-ProteinID:  XP_074899301 LinkDB All DBs Position 12 Genome browser AA seq 4968 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCTATVHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTEEKAEGLVDVEKWKFMMKSAQGGGHRTLLYGHAIL LRHSYSGMYLCCLSTSRSSMDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD LILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEVAQGYLIGGDVLRLLHGH MDECLTVPSGEHGEEQRRTVHYEGGAVSIHARSLWRLETLRVAWSGSHIRWGQPFRLRHI TTGKYLSLLDDKSLLLTDKEKADVKSTAFCFRSSKEKLDTGTRKEVDGMGAPEIKYGDSI CFIQHVDTGLWLTYQSADAKSVRMGSVQRKAIMHHEGHMDDGLTLSRSQNEESRTARVIR STVFLFNRFIRGLDALSKKAKSSTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLR ALKNRQNLFQEEGMINLVLECIDRLNVYSSAAHFADVAGKEAGEAWKSILNSLYELLAAL IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIICL LDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIF LGISEGSAQYRKWYYELMVDHLEPFVTAESTHLRVGWASTEGYSPYPGGGAEWGGNGVGD DLYSYGFDGLHLWSGCVARTVNSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFE NFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCFEAVLPKEKLKVEHSREY KQDRSYTRDLLGPTISLSQAAFTPVPVDTSQIVLPPHLERIREKLAENIHELWVMNKIEL GWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGIADEHAEEK VKKMKLPKNYQLLSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGI QQDVKNRRNPRLVPYALLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAMRLDVCSG IMEKFRIFRTEKTYAVKAGKWYFEFEAVTAGDMRVGWTRPGCLPDQELGSDEEAFVFDGF KAQRWHQGNEHFGRSWLAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFEVGDG FLPVCSLGPSQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITIWLSKRLPQFLP VPQNHEHIEVMRIDGTIDSCPCLKVTQKSFGSQNSKTDVMFFRLSMPIECAEVFSRSAAG GLPGSGLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRTEREKDATKPELNNHKDYVQEK PSRLKQRFMLRRTKPDYSTSHSARLTEDVLADDRDDYDYLMQTSTYYYSVRIFPGQEPAN VWVGWITSDFHQYDTSFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGR NNNGLEIGCLVDAASGLLTFTANGKELGTYYQVEPSTKLFPAVFAQATSPSVFQFELGRI KNVMPLSAGLFKSEHKNPVSQCPPRLHVQFLTHVLWSRVPNHFLKVDVSRISERQGWMIQ CLNPLQFMALHIPEENRTIDILELTEQEELLKFHYHTLRLYSAVCALGNNRVAHAMCSHV DESQLLYAIENKYMPGLLRAGYYDLLIDIHLNTYATARLMMNNEFIVPMTDETKSITLFP DENKKHGLPGIGLSTSLRPRMQFSSPSFVSISSECFQFSPEFPLEILKAKTIEMLTEAVQ EGSLHVRDPVGGSTEFLFVPLIKLFYTLLIMGIFHNGDLKHILQLIEPRVFKEAMSQEDE VDFSEKELSSDELKSEEGEEETRGEQVPKEGLLQMKLPEPVKLQMCHLLQYLCDCQVRHR IEAIVAFSDDFVAKLQENQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKD DKNDCPCPEEIRDQLLDFHEDLMTHCGIELDEDGTLDGNSDLTIRGRLLYLMEKVTYLKK KQAEKPVDDDAKTSSTLQQLISDTMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRA LPKTYTINSVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNL MRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYL LENSSVGLASPSMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCPLLI SKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGN GLLAAMEEAIQISEDPTRDGPSPSNGSSKTLEMEEQEDDTIHMGNAIMTFYAALIDLLGR CAPEMHLIHAGKGEAIRIRSILRSLIPLEDLVGVISIPFHMPTIAKDGTVVEPDMSAGFC PDHKAAMVLFLDRVYGIEDQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLC TAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEECLLSICGQLR PSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHLS RKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVNMMEKQSSMDSDGNF NPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMEKFANGWTYGETYSESAKVQPLMKQYK LLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQISVDTAHGY TPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKMELEAKVGGGNHPLLVPYDTLTAK EKAKDREKAQDILKFLQINGYVVSRGLKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYI LEFDGGSRGKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLSSGGHASNKE KEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKMALRAF LDNAAEDLEKTMENLKQGQFTHSRNQPKGVTQIINYTTVALLPVLSSLFEHIGQHQFGED LILEDVQVSCYRILASLYALGTSKSIYVERQRSALGECLAAFSGAFPVAFLETHLNKHNI YSIYNTKNARDRAVLNLPTSVEEVCPNIPSLVKLMEEIVELAESGIRYTQMPHIMEVILP MLCSYMSHWWEHGPENNPDKAEMCCTALTSEHMNTLLGNILKIIYNNLGIDEGAWMKRLA VFSQPIISKAKPQLLKTHFLPLMDKLKKKAAVVVSDEEHLRAEGRGDMSEAELLILDEFT TLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKREEQNFV VQNEINNMSFLISDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNI CAPGDQELIALAKNRFSMKDTEDEVRDIIRSNLHLQGKLEDPAIRWQMALYKDLPNRTED SSDPEKTVERVLDIANVLFHLEQRSACFGRGYFFWVEHPQRSKKAVWHKLLSKQRKRAVV ACFRMAPLYNLPRHRAVNLFLQGYDKSWIETEEHYFEDKLIEDLAKPGEEPPEEDESLKR VDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEEKEME KQKLLYQQARLHDRGAAEMVLQTISASKGEMGPMVAATLKLGIAILNGGNSTVQQKMLDY LKDKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVMQDDEFTCDLF RFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDE QGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQ DSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMF LKLKDLTSSDAFKEYDPDGKGIISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDY EEFVKRFHEPAKDIGFNVAVLLTNLSEHMPHDTRLQTFLELSESVLNYFQPFLGRIEIMG SAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEM QLAAQISESDLNERSANKEENEKDKPEEQDPRMGFFSLVTMKSALVALKYNLMTLMKMLS MKSLKKQMKKVKKMTMKDMVMALFSSYWSILMGLLHFACSVIRGFFRIICSLLLGGSLVE GAKKIKVAELLANMPDPTQDEVRGEGEEGERKPTEAALPAEDLTDLRTLSDESDLLSDIF GLDLKREGGQYKLIPHNPNAGLSDLLSTPSLAPMPEVQEKIQEQVKEDEKEEKEETKSEP EKAEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVQESAFWKKIIAYQQKLLNYFARNF YNMRMLALFVAFAINFILLFYKVSTSAVTEEKEVPVVSAAESMKLNSLESDNQRVIAVHY VLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITE QPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDF SDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFF AAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDG DMPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILL AIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYL FFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14907 nt NT seq  +upstreamnt  +downstreamnt atggccgaggggggcgagggcgaggacgagatccagttcctgcgaactgatgatgaagtg gttctgcagtgcactgcaactgttcacaaggagcaacagaaattgtgtcttgctgctgaa ggatttggcaacaggctttgctttttggaatccacatcaaattctaagaatgttccacct gatttgtccatctgcacctttgtgctggagcagtctctgtcagtacgggccctccaggaa atgctggctaacacagaagaaaaggcagaagggctagttgatgtggaaaaatggaaattt atgatgaagtctgcacaaggcggcggtcatcgaacgctactctatgggcatgcaatcttg ctgcgccattcctacagcggcatgtatctatgctgcctctctacatctcgatcttcaatg gataagctggcatttgatgtaggattgcaagaggacacaacaggtgaggcatgctggtgg accatccatcctgcttccaagcaacgatcagaaggagaaaaagtgcgtgttggagatgat cttattttagtcagtgtctcttcagaaagatatttgcatctctcttatggcaatggtagc ttacatgttgatgcagccttccagcagacactctggagcgtagcaccaatcagttcagga agtgaagttgcccaaggatatctgattggaggggatgttctgaggttattgcatggtcac atggatgaatgtttgacagtcccttcgggtgaacacggagaagaacaaagaagaactgtc cattatgaaggcggtgctgtgtcaattcatgctcgttccctttggcgactagagactcta agagttgcgtggagtggcagccacatcagatggggacagccattcagactaagacatata acaacaggaaaatatttaagtctcctggatgacaagagtcttcttcttacagacaaagag aaagcagatgtaaaatctacagcattctgttttcggtcctccaaggaaaagttggacaca gggacaagaaaagaagtggatggaatgggagcacctgaaataaaatatggggattcaata tgcttcatacaacatgtagatacaggcttatggctcacgtaccagtctgctgatgcgaag tctgtacgaatgggttctgtgcagcggaaggcaataatgcaccatgaaggtcacatggat gatggtttaacattgtccagatctcagaatgaagaatcccgaacagcacgtgtcatccgc agtacggtcttccttttcaacaggtttataaggggccttgatgctctcagcaagaaagcg aagtcttccaccgtcgatttgcctattgagtcagtcagtctgagccttcaggacttgatt ggatactttcacccccctgatgaacatttggagcatgaagacaaacaaaacaggctccga gcactgaagaatcgccagaacctcttccaggaagagggtatgatcaaccttgttcttgaa tgtattgatcgcttgaatgtatacagcagtgcagctcattttgcagacgtagctgggaag gaagctggagaagcatggaaatctattctgaattctttgtatgaattgctagcggctctg attcgagggaatcgtaaaaactgtgctcagttttctggatctcttgattggttgatcagc agattagaaagactggaagcctcttctggaattctggaggttttacactgtgtgttggtg gaaagcccagaagctctaaacattattaaggaaggacatattaagtcaatcatctgtctt ttggacaaacatggaagaaaccataaggttttggatgtattgtgttctctctgtgtttgt catggagtagctgttcggtctaatcaacatctaatctgtgacaatctcctgccaggaaga gatctgctcttacagacacgccttgtcaaccacgtgagcagcatgcgacccaacatcttc ttggggattagtgaaggctctgcccaatacagaaaatggtactatgaacttatggtggac catctagagccctttgtgactgcagaatcaactcatctacgagtgggctgggcttcaaca gagggctactcaccatacccagggggaggagcagaatggggaggaaatggtgttggtgat gacttgtattcctatggtttcgatggtctgcatctgtggtcaggttgtgtagcacgaaca gtaaattctcccaaccaacatctgttaagaactgatgatgttattagctgctgtttggac ctgagtgcccccagcatctctttccggataaatggtcagccagttcaaggaatgtttgag aatttcaacatagatggcctcttcttcccagttgtcagcttctctgcaggaataaaagta cgtttcttacttggaggtcgccatggagagttcaagttccttcctccacctggatatgcc ccttgctttgaagctgtactaccgaaagagaagctgaaagtggagcatagccgagagtac aagcaggatcgtagctatacaagagacctactgggtcccactatctctctgtcacaagca gctttcactccagttcctgtagatactagccagattgttttgcctccccacctggaaagg attagagaaaaattagcagagaacatccatgaactttgggttatgaataagattgaactt ggctggcagtatggaccagttagagatgacaacaaaagacaacacccatgtttagtggag ttctcaaaattgccggagcaggaaagaaattataacttgcagatgtcacttgaaacactg aaaaccctgctggcattaggctgccatgttggaattgctgatgaacatgctgaagaaaaa gtgaaaaaaatgaaacttccaaagaactaccagttgttgagtggatataagcctgctccc atggatctgagttttatcaaactgaccccttctcaagaagctatggtggataaactagca gagaatgctcacaatgtgtgggcaagggaccgtataaggcaaggctggacatatggtatc cagcaggatgtgaaaaatcgacgaaatcctcgccttgtgccttatgctcttttggatgat cggacgaagaagtcaaacaaagacagtcttcgggaagcagtccgcacccttctaggctat ggttacaacctggaagctcctgatcaagatcatgcaatgagactggacgtgtgcagtggg ataatggagaaattcaggatcttccgcacagaaaagacttatgcagtgaaggctgggaag tggtactttgaatttgaggcagttactgcaggagacatgagagttggctggaccaggccg ggttgtctgccagatcaggaacttggctcagatgaagaagcttttgtttttgatggcttt aaggcacagcggtggcatcaaggtaatgagcattttggccgctcttggttagcaggagat gtcgttggatgtatggttgacatgaatgagcacactatgatgttcaccttaaatggtgaa atcttgcttgatgactcaggttcagaacttgcattcaaggactttgaggttggtgacgga tttctacctgtgtgcagcctgggcccatctcaagtggggagaatgaactttggaaaagat gtcagcacgctaaaatatttcactatctgtggcttacaggaagggtatgaaccctttgct gttaatacaaacagagacatcaccatttggctgagtaaaaggctccctcagtttctacca gtgccacaaaatcatgaacatattgaggtgatgagaattgatggcaccatagacagctgc ccctgcctgaaggtcacacagaagtcctttggttcacagaacagtaaaacagacgtcatg ttttttcgattaagcatgcccattgaatgtgctgaggtattctccagatcagctgcagga gggttaccaggctctggtctttttggcccgaagaatgacttggaggattatgatgctgat tctgattttgaggttctaatgaaaactgctcatggtcatctagttcctgaccggacagaa cgagaaaaagatgccacaaaaccagagttaaacaaccataaagattatgttcaagaaaag ccttcacgtcttaaacaaagatttatgctcaggaggacaaagccagattatagcactagt cactctgcacggcttactgaggatgtgctagcagatgatagggatgactatgattatttg atgcaaacttccacgtactattattcagtgagaatatttcctggtcaagaacctgccaat gtctgggtgggctggattacatctgactttcaccagtatgacacaagctttgatttggac agagtgcgtactgtcacagttacactgggagatgaaaaagggaaggttcatgagagtata aaacgcagcaactgctatatggtgtgcgcaggagaaagcatgagccctggacaaggacgt aataataatggtctggagattggttgcttggttgatgctgccagtggcttgctgactttc acagctaatggcaaggaactaggcacatactatcaggttgaaccgagtacaaaattattt cctgctgtatttgctcaagctacaagccccagtgttttccagtttgaattgggaagaata aagaatgtaatgccattatctgctggcttattcaaaagtgaacacaaaaacccagtctct caatgtcctccacgacttcatgtccaatttctgactcatgtgctttggagcagagtgcca aaccacttcttgaaggttgatgtctctcggatcagtgaacgtcaagggtggatgatacag tgcctgaatcctttgcagttcatggcccttcatattcctgaagaaaacagaacaattgat attttagagctgacagaacaagaagaattgctgaaatttcactaccataccctccgatta tattcagcggtttgtgctttaggcaacaaccgagtggcccatgctatgtgtagccatgtg gatgaatctcagctcctgtatgctattgagaataaatatatgccaggattattacgtgca ggatattatgacttactcattgacatccatctcaatacctatgcaactgccaggttaatg atgaataatgaatttatagttccaatgacagatgagaccaagagtattactttgtttcct gatgaaaacaaaaaacatggcctccctggtattggacttagcacttcattaaggccaaga atgcagttctcctctccgagttttgtaagcattagcagtgaatgctttcagttcagtcct gaattccctctggaaatcttaaaggccaaaacgatagagatgctgactgaagctgttcag gagggcagcctccatgtcagagatccagttggaggttctacagaatttctgtttgtccct ctcatcaagctcttttataccctcctaattatgggaatcttccacaatggggatctgaaa cacatcttgcagttgattgagcccagggttttcaaagaagcaatgagccaggaggatgaa gttgatttctcagagaaggagctgagttcagatgagctcaagtcagaagaaggagaggaa gaaaccagaggggagcaagtgccaaaggaaggactccttcagatgaaacttccagaacct gttaaattacagatgtgccatctactccagtacctgtgtgattgccaagtacgacaccga atagaagccattgtagcattttcagatgattttgtggccaagcttcaagagaatcaacgc ttccggtacaatgaagtgatgcaggccttgaacatgtctgctgccctgaccgctagaaaa acaaaagaatttcgatccccacctcaggagcagattaacatgctgctgaactttaaagat gataaaaatgattgtccttgccctgaagaaattcgggatcaactcttggatttccatgaa gacctaatgacacactgtggaattgaactagatgaagatggaaccttggatggaaacagt gatttaaccattaggggtcgcctcctatatcttatggaaaaagttacatatctgaagaag aagcaagctgagaagccagttgatgatgatgctaagacatcctctactcttcagcagttg atttcagacacaatggtacgctgggcccaggaatcagtgatagaagacccggagttagta agggccatgtttgtgttgctacaccgccaatatgatggtattggtggcctggttcgagcc ctaccaaagacgtacaccataaatagtgtgtctgtggaagacacaatcaatcttctggca tccctcggccaaatccgttccttgcttagtgtcagaatggggaaggaggaagagaaactt atgattcgtggattaggagacatcatgaataataaagtattttaccaacatccaaatctc atgagagctttaggcatgcatgaaactgtcatggaagtgatggtaaatgtgcttggtgga ggagaatccaaggaaatcactttcccaaagatggtggcaaactgctgtcgttttctatgt tatttttgccgcatcagcagacagaatcaaaaagctatgtttgatcatcttagctattta ttggaaaacagcagtgttggccttgcctctccttctatgcgaggatcaactcctttagat gttgcagcagcctctgtgatggataacaatgaacttgcactagctttaagagaacctgat ctggagaaggtggttcgctacttggctggatgtggattgcagagttgtcctttgttgatt tctaaaggctacccggacatcggatggaatccagttgaaggagagcgatatttggatttt cttcgttttgctgttttttgcaatggagagagtgtggaggagaatgctaatgttgtagtc agactgcttatccgtcgacctgaatgttttggtccagctctaagaggagaaggaggcaat gggttacttgctgccatggaggaagcaatacaaatatcagaagatccaacaagagatgga ccttccccaagtaatggatctagtaaaacccttgaaatggaagaacaagaagatgacact attcacatgggaaatgcaatcatgaccttttatgctgctttgattgatctgttaggacgt tgtgcccctgaaatgcatctaatccatgctggtaaaggggaagctattagaatcagatca attctacggtctttgattccactggaagatttggtgggagtaattagtattcctttccac atgccaaccatagctaaagatggtactgtggtggaacctgacatgtctgcggggttttgc ccagatcacaaggcagccatggttttgttccttgacagggtctatggaattgaggaccag gattttcttctacaccttcttgaagttggctttctgccagatcttcgtgctgctgcttct ttagatacagctgctttaagtgctacggatatggctttggctctgaatcgatacctttgc acagcagtcttgcctctgttgaccagatgtgctcctctttttgctggcacagagcaccat gcttccctcatcgattccttattacatactgtgtacagactctcaaagggatgctctctt accaaagctcagcgagattcaattgaagagtgtttgctgtctatctgtgggcagttgcgg ccttccatgatgcagcatttgctgagaagattagtattcgatgttcctctattaaatgaa catgcgaagatgcctctcaagttgctgacaaatcattatgaaagatgctggaagtattat tgtttgccaggtggatggggtaactttggtgctgcctcagaagaagaacttcatttatcc agaaagttgttctggggtatttttgatgctttgtctcaaaagaagtatgaacaagaactg ttcaaattggctttgccttgtttgagcgcagttgcaggggccttacctccagactatatg gaatcaaattatgtcaatatgatggaaaaacagtcttcaatggattcagatgggaacttt aatcctcaacctgttgatacatcaaacattacaatccctgaaaaactagaatatttcatt aacaaatatgcagaacactctcatgacaaatggtcaatggaaaagtttgccaatggatgg acatatggtgaaacgtattctgaatctgcaaaagtgcaaccattaatgaaacaatataag ttactatctgaaaaggagaaagaaatttatcgatggccaatcaaagaatccctgaaaact atgctggcatggggatggcgaattgaaagaacacgggagggagattccatggcactgtat aatcggacacgtcgcatatctcaaaccagtcaaatctctgtagatacagcccatggttac actcctcgagcgattgacatgagcaatgtcaccctctccagagacttacatgctatggcc gagatgatggctgaaaactaccataacatatgggcaaagaaaaagaaaatggagcttgaa gcaaaagtaggaggaggcaaccatcctcttcttgttccttatgatacactcacagccaaa gaaaaagccaaggacagagaaaaagcacaggatattctgaaatttctacagattaatgga tatgttgtctccagaggacttaaggacctggaattggacacgccttccattgagaaacgc 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atgctatgtagttacatgtcacactggtgggagcatgggccagaaaacaaccctgacaag gctgaaatgtgttgcacagccttgacatcagagcacatgaacactctgttgggtaacata ttgaaaatcatctataacaaccttggtattgatgaaggagcctggatgaagagattagca gtgttttcccagcccatcataagcaaagcgaagccacagctcttaaagacacacttcctg ccactgatggataagctaaagaaaaaagcagcagtggttgtatcggatgaagaacatcta agagcagaaggcagaggtgacatgtcggaggctgaactgctcatcctagatgagttcacc actttggcacgggacctctatgccttctaccctttgttgattagatttgtggactataac agggcaaagtggctgaaagagcccaaccctgaagcggaagaattgttccgcatggtggct gaggtcttcatttactggtcaaagtctcataatttcaaaagggaagagcagaactttgtg gtacaaaatgaaatcaacaacatgtctttccttattagtgacaccaaatctaagatgtcc aaggcagcagtttctgaccaggagaggaagaagatgaagcgaaaaggtgaccggtactct atgcagacctctctcattgtggcagcattgaagagattacttcctattggcctaaacatt tgcgctcctggagaccaagagctaattgcactggccaaaaatcgattcagtatgaaagat actgaagatgaagtacgagacatcatccgcagtaatcttcacctccagggcaagcttgag gatcctgccattaggtggcagatggcactttacaaagatttaccaaacaggactgaagat tcctcagatccagagaagactgtggaaagggtccttgatatagctaatgtactgtttcac 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gttcaggaatccattagtgatttctattggtattactctgggaaggatgttattgatgag caaggacaacgaaatttttccaaagccatccaggttgcaaaacaagttttcaatactctt acagagtatatccaggggccatgtactgggaatcagcaaagcctggcacacagcaggcta tgggatgctgtggttggttttcttcatgtgtttgcccacatgcagatgaagctgtctcag gattccagtcaaattgaattactgaaggaattaatggatcttcagaaggatatggttgtc atgttgctgtctatgctggaaggtaatgttgtgaatggaactattggcaagcagatggtc gatatgcttgtggaatcgtctaacaatgtggagatgattctgaagttttttgatatgttc ttaaaattgaaggatttgacttcctctgatgcattcaaagaatatgaccctgatggtaaa gggataatttcaaagagggattttcacaaggcaatggaaagccataagcattacacccag tctgaaactgagtttctactatcgtgtgctgaaacagatgagaatgagactctggactat gaggagtttgtgaaacgattccatgaacctgccaaagacattggtttcaatgtcgctgtt ctcctgaccaacctgtcagaacacatgccacatgacacccgcttgcaaacttttcttgaa ctgtcagagagtgtgctgaattactttcagcctttccttgggcgcatagaaatcatgggc agtgcaaagcgcattgaacgagtttattttgaaataagcgagtcaagtcggactcagtgg gagaaacctcaggtaaaagagtcaaagagacaattcatatttgatgttgtaaatgaaggc ggggagaaagaaaagatggagctttttgttaatttctgtgaggataccatctttgaaatg caactggctgcccagatctctgagtcagatctgaatgaaaggtcagcaaataaagaggag aatgagaaagataagcctgaagaacaggatcctagaatgggtttcttctcccttgtgacc atgaagtcagcattagtagcgctcaagtataatttaatgactcttatgaaaatgctcagc atgaaaagcctaaagaaacagatgaaaaaggtgaagaaaatgaccatgaaggatatggtc atggccttgttttcttcctattggagcattttgatgggcttactacattttgcttgtagt gtcatccggggcttctttcgcatcatatgcagtttgctgcttggaggaagcctagtagaa ggagcaaagaaaatcaaggtggctgaactattagctaatatgccagatcccactcaggat gaggtgcgtggggaaggagaagagggggaaaggaaaccaacagaagctgcattgcctgca gaagacttgacagatctgagaactttgtcagatgagagtgatctactctcagatatattt ggtttggatttgaaacgagaaggtgggcagtataaattgatccctcacaatccaaatgct ggattgagtgatttactgagcactccctccttagctccaatgcctgaggtgcaggaaaaa atccaggagcaggtgaaagaagatgaaaaggaagagaaggaggaaacaaaatctgaacct gaaaaagcagaaggagaagatggagaaaaagaagagaaagccaaggaagacaaagggaaa cagaaattgagacaactccatactcacagatatggagaaccagaagttcaggaatcagct ttctggaagaagatcattgcataccaacagaagcttcttaattattttgcgcgaaacttt tataacatgaggatgttggcgttgtttgttgcttttgccatcaacttcatcctgcttttc tacaaggtctccacctctgctgtgacagaagaaaaggaagttcctgtggtatctgctgct gaaagtatgaagttaaacagcctggaaagcgacaaccagagggtcattgcagtgcattat gtcctggaagaaagcagtggctacatggagcccacactgcggattttggccatcctgcac acagtcatctcattcttctgcatcatagggtattactgtttgaaagttccactggttatt tttaagagagaaaaggaggtggcaaggaaattggaatttgatgggctgtatataactgaa cagccatcagaagatgatattaagggacagtgggacagactcgtaatcaacacacagtct tttccaaataattactgggacaaatttgtgaaaagaaaggtcatggataaatatggtgag ttctatggccgtgacaggatcagtgagttactaggaatggacaaagctgctctcgatttt agtgatgctcgagaaaagaagaaaccaaagaaggatagctccttatctgctgtgttaaat tccattgatgttaagtatcagatgtggaaattaggagttgttttcactgataattctttc ctttacctagcgtggtacatgaccatgtcagtccttggccattacaacaattttttcttt gctgctcatctccttgacattgcaatgggattcaagactttacgaactatcctgtcatca gtgactcacaatggcaaacagcttgtcctaacagtgggattactggcagtagtagtatac ttgtatacagtagtggcattcaattttttccgcaagttctacaacaagagtgaagatggt gatatgccagacatgaaatgtgatgatatgctaacatgctacatgtttcacatgtacgtt ggagtacgtgcaggtggaggcattggtgacgagatcgaggatccagcaggagatgaatat gaaatctatcggattatctttgacatcactttcttcttctttgtgattgtcatcctgctt gcaattattcaaggtttaattattgatgcttttggtgagttaagagatcagcaagagcaa gttaaggaagacatggagacaaagtgctttatctgtggaataggaaatgactactttgat acagtgccccatggctttgaaacacacacactacaggagcacaacttggccaattatttg ttttttctgatgtatcttattaacaaagatgaaacagagcatacaggacaggaatcctat gtatggaaaatgtatcaagaacggtgctgggagtttttccctgctggtgattgcttccga aaacagtatgaagaccagctcaattaa

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