Bradysia coprophila: 119072156 Help Entry 119072156         CDS       T08269                                  Name (RefSeq) ryanodine receptor isoform X1   KO K04962   ryanodine receptor 2 Organism bcoo  Bradysia coprophila Brite KEGG Orthology (KO) [BR:bcoo00001]  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:bcoo04040]     119072156    04990 Domain-containing proteins not elsewhere classified [BR:bcoo04990]     119072156 Ion channels [BR:bcoo04040]  Voltage-gated cation channels   Ryanodine receptor    119072156 Domain-containing proteins not elsewhere classified [BR:bcoo04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    119072156 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR Ins145_P3_rec SPRY MIR RR_TM4-6 RIH_assoc Ion_trans EF-hand_7 TPR_TTI1_C Motif Other DBs NCBI-GeneID:  119072156 NCBI-ProteinID:  XP_037033203 LinkDB All DBs Position IV:590454..647539 Genome browser AA seq 5144 aa AA seqDB search MAEAEGGSEQDDVSFLRTEDMVCLSCTATGERVCLAAEGFGNRHCFLENIADKNIPPDLS QCVFVIEQALSVRALQELVTASGSETEGDSLGKGTGSGHRTLLYGNAILLRHQNSDMYLA CLSTSSSNDKLSFDVGLQEHSQGEACWWTVHPASKQRSEGEKVRVGDDLILVSVATERYL HTTKENDLSIVNASFHVTHWSVQPFGTGISRMKYVGFVFGGDVCRFLHGGDECLTIPGTW SPEPEQNIVIYEGGSVMAQARSLWRLELARTKWSGGFINWSHPMRIRHITTGRYLGVNDS KELVLFRHTEANLQKTTFCLRQEKDDQKIVLEDKDLEIIGAPIIKYGDSTVILQHSETGF WVSYKSYETKKKGVGKVEEKQAILHEEGKMDDGLDFSRSQEEESKTARVIRKCSSLFTKF INGLETLTQNRRHSMFFLTVNLAELVACLEDLINYFTQPPDDMEHEEKQNRFRALRNRQD LFQEEGVLNLILEGIDKINVITSQGFLAGFLVNEETATNWELISGYLYQLLAAIIKGNHT NCAQFANSNRLNWLFSRLGSQASSEGSGMLDVLHCVLIDSPEALNMMRDEHIKVIISLLE KHGRDPKVLDVLCSLCVGNGVAVRSSQNNICDYLLPGKNLLLQTQLVDHVASIRPNIFVG RVEGSSMYQKWYFEITVDHIEQTTHMTPHLRIGWANTAGYIPYPGGGKKWGGNGVGDDLY SFGFDGAFLWTGGKSTAVLSDLPLEPYIRKNDVVGVALDLSVPIIYFTFNGARVRSNFRD FNLDGMFFPVMSCSSKLSCRFLLGGDHGRLKYVPPMGFSPLVQCLMPHQILSLDPCFYFG NLNKNVLAGPFLIEDDTPFVPNPVDTATVALPSSVDSIKEKLAENIHEMWALNKIEAGWT WGERRDDLHRIHPCLTQFEKLPHAEKRYDSQLAVQTLKTIIALGYYITMDKPPARIRPIR LPNEPFMQANGYKPAPLDLSAVSLTPKLEDLVDQLAENTHNLWAKERIQQGWTYGLNEDS DNHRSPHLVPYAKVDEAIKKANRDTASETVRTLLVYGYNLDPPTGEGNEALLAEALRLKF AAFRTYRVERNYAVTSGKWYFEFEVLTAGPMRVGWAKADCSPGAMLGADETTWAFDGYNE EKVYGGSTESFGKQWGPGDVVGVFLDLVDHTISFSLNGELLMDALGGETTFADVTAEDVG FVPACTLGVGQKARLTYGQNVDLLKYFTTCGLQEGYEPFCVNMRRPVTHWYTKDQPIFEN TDDMMDCRIDVARIPGGSDTPPCLKISHNTFETMEKANWEFLRLSLPVTCLSDFISEQEK RRRWDEIKIRQHRLQSEMNESQAEAPAHIDHIMKSGFTMNDLKGLNRNFGDDAAEADDML RSNPQRPPRKLSLTQNGYDSAEMNVQMQRSASALNIEPFQPEDGAALEEGVDKKRSRSPF KFFKKNRSQSKDKFKSKSKSPDAVNRRVMGRNVGPPQMAGKSPKVKASDTDLKNHAHSER PSNGKTTMTVSALGTHIESSGNEVYDAECMKLINEYFYGVRINPGQDPTHVYVGWVTTQY HLHSREFNSKKVRKGSVFIEDDYQQVIDRIDRQSCYVVRADELYNEVTQDATGKGATQGM FVGCFVDTAMGVIRFTCEGKETSHRWQMEPETKLFPAIFVEATSKEILQIELGRTPTTLP LSAAVLPTSDKHVNPQFPPRLKVQCLKPHQWARVPNQFLQVHALKLSDIRGWSMLCEDPV SMLALHIPEEDRCVDILESIEMDKLLSFHSHTLTLYAALCYQSNYRAAHALCLHVDQKQL LYAIKSEYMCGPLRQGFYDLLIALHLESHATTMEVCKNEFIVPLGPGLKELYRDTEMCHS LRSLQTESVRPILRMTDIAEPHFLPHYTSNLAPAVSSDQIPTIDSLYSPKFALEVVRTFV MEALAEAVEVNQVHNRDPIGGSNENLLLPLLKLTDRLLLVGILTDEDIQKLLIMIDPETW DSTFDREGKDEHRKGLLTMKMAEGAKLQMCYLLHHLSDVQLRHRVESIVAFSHDFVGDLQ ADQLRRYIEIKASDLPSAVAAKKTREYRCPPREQMNAILGFKDMDSTDVENCPCGVDLRD NFMTFHEQFLSKISLNALEEPEPEEEVEEVPQPGPFTKFYNFINVKEEEPVVEPEEPEIK TPEELFRKVLIKTIIGWAKESQIEMPKLVREMFSLLVRQYDTVGEMIRALERTYVINTKT KADVAGMWVGLSQIRALLPVQMSQEEEELMRTRLWRLVNNHTFFQHPDLIRILRVHENVM AVMMNTLGRRAQSIGDAPVQSEGGEAPVKEKDTSHEMVVACCRFLCYFCRTSRQNQKAMF DHFDFLLENSNILLSRPSLRGSTPLDVAYSSLMENTELALALREHYLEKIAVYLSRCGLQ SNSELVEKGYPDLGWDPVEGERYLDFLRFCVWVNGESVEENANLVIRLLIRRPECLGPAL RGEGEGLLRAIIDANKMSERISERRKYHEEPESEMDADFVHPLPEGEEDEDYIDTGAAIL GFYCTLVDLLGRCAPEPSVIDLGKNESLRARAILRSLVPLEDLQGVLGLKFTLQQQAPGE ERPKSDVPSGLLPGHKQSIVLFLERVYGIETHELFFKILEEAFLPDLRAATMLDKNDGSE SDMALSMNRYIGISILPLLIKHSRFYSEADNYASLLDAALHTVYRLSKNRMLTKGQREAV SDFLVALTSQMQPAMLLKLLRKLTVDVSKLSEYTTVALRLLTLHYERCAKYYGSSQAQTT YGASSDEEKRLTMMLFSNIFDSLSNMEYDPELFGKALPCLIAIGCALPPDYSLPQKNDDD PYDNATGNPDNPQYNPQPINTSNITLDNDLNSIVQKFSEHYHDAWASRKMEAQWQFGDSW SDSSKTHPRLKPYGMLNDYERERYKEPVRDCLKALLALNWSVEHSDADAPLSHRGSTRRQ SKPTVDFQAEGSNAFDYNPHPVDMTNLTLSREMQNMAERLAENSHDIWAKKKREEIDTSG GIIHPQLVPYDLLTDKEKKKDRERSQEFLKYMQYQGLKLHRPSKAGVGSVEGEPGVIQAS IELRFAYSLLEKLIAYLDRATINMKMLRPSATFSRRTSYKTASRDIKFFSKVVLPLMEKY FSTNRGYFIAVATATNNIGAASLKEKEMVAAIFCKLASLLRHRLSAFGPDVRVTVRCLQV LVKAIDAKSLTKNCPEFIRTSMLTYFNNTADDLGQTIVNLQDGKFSHLRGTHLKTSTSLT YVNQVILPVLTAMFDHLASCDYGSDMLLDEIQVASYKILAALYTLGIDPTLTNDRKYLKT EIERNKPSLGSCLGSFSSTFPVAYLEPHLNKHNPFSLLNRIADHSLEAQDIMVKMESSMP NLETIMAEVDQFVDSDKTYNDSPHIIDVILPLLCSYLPFWWSQGPDNVSPTNDNHVTMVT ADHMNHLLTNVLKLIKKNIGNENAPWMTRIAAYTQQIIINSSEELLVDVFLPLAERMKKR TENMFHKEESMRGFIKSAADDTSQVEGQIQTDWQLLVRDIYSFYPLLIKYVDLQRNHWLK NNIHEAEELYNHVAEIFNIWSKSQYFLKEEQNFISANEIDNMALIMPTATRRGANVNEGA PVTGGKVKKKKKNRDKKRDKSKEVQASLMVACLKRLLPVGLNLFAGREQELVQHCKDRYL KKMLETDVIEFARTQLTLPDKLDPADEMSWQHYLYSKLGKKESEPDDTSEKLPTPATAIE KTKEKIIEETADRIVAMAKVLFGLHMIDHPQQQSKNVYRSVVSIQRKRAVIACFRQATLH SLPRHRACNIFARTYFEIWLGAENVGQEVMINDLTQSFEEAEKQRKLGDEPVAKPDPLSQ LVVTFCRGAMTERSGALQEDPLYMSYAHIVAKSCGEEAEEEEEEESEEGERSAIHFSMEI FWRQEMEKQKLLYAQKRLNKRGVSEMVLLHISASKGIPSEMVMTTLQLGISILRGGNIDN QMGMLNHLKDKKDVGFFTAIAGLMNSCSVLDLDAFERNTKAEVYTSSMGSGLGCGSEGAA GEKNMHDAEFTCALFRFIQLTCEGHNLEWQNYLRTQAGNTTTVNVVICTVDYLLRLQESI MDFYWHYSSKEVIDTAGKANFFKAIGVASQVFNTLTEVIQGPCLLNQQALAHSRLWDAVC GFLFLFSHMQNKLSRHSSQNDLLTELNNLQKDMITMMLSMLEGNVINGTIGKQMVDTLVE SASNVELILKYFDMFLKLKDLISSPSFLEIDHNMDGWVFPKDLKEKMELTKNYTPEEIEF ILVCMEVNHEGKVDYETFSDRFHESAKDIGFNLAMLLTNLSEHMPNEPRIARFLETAGSV LSYFEPFMGRIEIMGGSKRIERVYFEIKESNIDQWEKPQIKESKRAFFYSMVTEGGDKEK LESFVNFCEDAVFEMQHASGLMSTDDGSSTTRKEAQYTFMSEEDEERAAKDPIRRSVQAV KDGFHYAIHMFSPANIKYQIGVMQTMSIPELIIGFFKTFFYAFYYSGFGVSQVIKYIFGI LMSLMRGPAEEYVQIVPIEEEKTMRALPALPSEETTGTVSAFGLDISKEDTGQYRIAPHE SNQPSPTSSMEETGESGPDDASPTGELKADGEPVEQPMTLVDLLGGDAAKRADQERSEAQ KIQEAAMASIEAEAKRSTETQAEPAAVAQIDVSHYTHKVVSFLARNFYNLKYVALILAFC INFMLLFYKVNVFGEDGDGDGDDDLIGFGSGSGSGFGGSGSGSGDGDDEDEDALETVIVN EDFFYMEHVIRLAAFLHSLCSLAMLIAYYHLKVPLAIFKREKEIARRLEFDGLFIAEQPE DDDIKSHWDKLVISTKSFPVNYWDKFVKKKVRQKYCETYDYDSISNLLGMEKNVYKTGPE VEEQTGLIAYILNIDWRYNVWKAGVTITDNAFLYALWYFCFSLLGNFNNFFFAAHLLDIA VVIPSLKTILQSVTHNGKQLMLTVMLLTIIVYIYTVIAFNFFRKFYIQEEDDEVDKKCHD MMTCFVFHLYKGVRAGGGIGDEIGDPVGDDYEVYRILFDITFFFFVIVILLAIIQGLIID AFGELRDQLESVKEDMESNCFICGIGKDYFDKVPHGFDTHVQQEHNLANYMFFLMHLINK PDTEFTGQETYVWNMYQQRCWDFFPVGDCFRKQYEDELGIGGGG NT seq 15435 nt NT seq  +upstreamnt  +downstreamnt atggctgaagcggaaggaggatcggagcaggatgatgtttcattcttaagaacggaagac atggtttgcctatcatgtacagcaacaggcgaacgtgtatgtttagcagctgaaggattt ggcaatcgtcactgtttcctcgaaaatattgccgataagaatattccaccggatctatcg caatgtgttttcgtaatcgaacaggcactgtcagtgcgtgccttgcaggaattggttaca gcctctggttcggaaacggaaggagattcattaggaaaaggaacgggttcaggtcacaga actctactgtatggtaatgccattcttttacgccatcaaaacagtgatatgtacttagca tgcttatcaacatcatcgtccaacgacaaattgtctttcgatgttggtctgcaagaacac agccaaggtgaagcgtgctggtggacggtacatccggccagtaaacagagatcagaaggt gaaaaagtacgagtgggagatgatttaattttggtgtctgttgcaactgaacgttatttg cacacaaccaaagagaatgatttatccattgtgaatgccagctttcacgtaacacattgg tcggtacaacctttcggcacgggtatatctcgtatgaaatatgtgggcttcgtattcggt ggagatgtgtgtagatttctgcatggcggtgacgagtgtttgactataccaggaacgtgg agtccagaacctgaacagaatatcgtcatatatgaaggtggttcggtaatggcacaggcc agatcactgtggcgattagagttagcaagaacaaaatggtctggaggttttattaactgg agtcatccgatgcgaattcgtcatatcaccacaggaagatatctgggtgtgaacgatagc aaagaacttgttttgtttcgtcatacagaagccaatcttcagaaaacaacattttgtctc cggcaagaaaaggacgatcaaaaaattgtactcgaagataaggatctggaaataatcggt gcaccaatcatcaaatatggtgattcgactgttatactacagcattcagaaacgggattt tgggtcagttacaaatcttacgaaacgaagaaaaaaggagtgggaaaagtcgaagagaaa caggcaatccttcacgaagaaggtaaaatggatgacggcctggacttctcccggtcccaa gaagaagaatcgaagactgctcgcgtcattcgaaagtgtagcagtctatttacgaaattc attaatggcctcgaaacgttaacacaaaatcgtagacattcgatgttcttcctcacagtc aacctagccgaattggttgcgtgtttggaagatttgataaattatttcacacaacctccc gatgatatggagcacgaagagaaacaaaatcgtttccgggcactgcgcaatcgtcaagat ttgttccaggaggagggtgttctcaatttgatcttggaaggcattgacaagatcaatgtc attacatcacaaggatttctagctggattcttggtgaacgaagaaaccgccaccaactgg gaattgatttccggttatctgtaccaactcttagccgccatcattaagggaaatcacacc aattgtgcacagttcgccaattcgaatcgattgaattggttgttctcgcggttaggttcg caggcgtccagtgagggatctggcatgttagacgtgctacattgtgtgctcatcgattcg ccggaagcgttgaatatgatgcgagatgagcacattaaagttatcatcagtttgttggaa aagcatggccgcgatcccaaagttctggatgttttgtgttcactatgcgtgggtaacggg gttgcggttcgatcgtcgcagaacaatatttgcgattatttgttacctggcaaaaatctc ttgttgcaaacccaattggtcgatcatgtggccagcattcgtccaaatatatttgtcggt cgtgtagaaggatcgtccatgtaccaaaagtggtactttgaaatcaccgttgatcatatc gagcaaaccactcacatgacgccgcatttacgtatcggatgggcgaatacagccgggtac attccctatccaggcggaggaaaaaaatggggtggaaatggtgtaggagatgatttatac tcgttcggtttcgatggtgcatttctatggacaggcggtaagagcacagctgtcctttca gatctaccgttggaaccgtacatacgtaaaaatgacgtagtcggtgtagcactcgatttg agtgttccaattatttatttcacatttaacggagcgagggttcgttccaactttagagat ttcaatctcgacggaatgttctttccagtcatgagttgttcatcgaaactgagctgtcga tttttacttggaggagatcacggtcgcctgaaatatgttccaccaatgggattctcgcca cttgtacaatgcctaatgcctcatcagattctcagtctcgatccctgtttttacttcggc aatttgaacaagaatgttttggcggggccatttttaattgaagacgatacaccgtttgtg ccaaatccagtcgatactgcaaccgtagcattgccgagctctgtcgattcgatcaaagaa aaattagcggaaaatatccacgaaatgtgggcgttgaataaaattgaggctggatggacc tggggcgaacgtagagatgatttgcacagaatacatccttgcttgacgcaattcgagaaa cttccgcatgcagaaaaacgttacgattcacagttggccgtacaaacgttgaaaacgatt atcgctctcggttactacataacaatggacaaaccaccagcgagaattcgtcccattcgt ttaccgaacgagccgtttatgcaagcaaacggttacaagcccgccccgctagatctgagt gccgtatccttaacaccgaaattggaagatcttgtcgatcaactggccgaaaacacacac aatctatgggccaaggagcgaatacaacaaggatggacgtatggactgaacgaagactca gataatcatcgcagtccacatctggtaccgtatgctaaagttgacgaggcaatcaaaaaa gcaaacagagatacagcctccgagactgtacgaacgctattggtgtacggctacaatttg gatccaccaactggcgaagggaacgaggccttattggcagaagctttaagactaaagttt gcagcgtttcgtacatatcgcgttgaacgtaactatgctgtaacgtcgggcaaatggtac ttcgaatttgaagttctgacagcaggtccgatgagagtcggatgggctaaagcagattgt agtcctggagcaatgttaggtgctgacgaaaccacttgggcatttgacggttataatgaa gaaaaagtttatggaggctcgaccgagtctttcggaaagcaatggggtcccggtgatgtt gtcggtgtcttcttagacttggttgatcataccatcagtttttcactgaatggtgagctg ttaatggacgcattgggtggtgaaacgacattcgctgatgttaccgccgaagatgtagga tttgtaccggcttgtacattaggagtcggccaaaaggctagactaacatacggacaaaat gtcgatttactgaaatatttcacaacgtgcggtctacaagagggatatgaaccgttttgt gtaaatatgcgacgacctgttacccactggtacactaaagatcaaccaattttcgaaaat actgatgacatgatggactgtcgaatcgacgtagctagaatacctggaggatccgataca cctccgtgcttgaaaatttctcacaacactttcgaaacaatggagaaggcaaattgggag ttcttaagattgtcactgccagtcacttgcctgtctgactttattagtgaacaagaaaaa cgtcgtcgatgggacgaaattaagataagacaacaccgattgcagtcagaaatgaatgag tctcaggcagaagcgccagcgcacatcgatcatattatgaaaagtggttttaccatgaac gaccttaaaggattgaacagaaattttggagacgatgcagccgaagctgatgatatgttg agatcaaatccccaaagaccaccacggaaattgtcgttaactcagaacggatatgacagt gcagagatgaatgttcaaatgcaacgttcggccagcgcgttaaacatagaaccatttcag ccagaagatggtgccgcactggaagagggtgttgacaaaaagagaagccgaagtccgttt aaatttttcaaaaagaatcgttcacagagcaaggataaatttaagtcgaagtcaaagtct ccagacgcagtgaataggcgcgtaatgggccgaaatgtcggtccacctcaaatggcgggc aaatccccaaaagtcaaagcatcggatactgacctaaaaaatcacgcacattcggaacgg ccatcaaacggcaagacgacaatgacagtgagtgcattgggcactcatatcgaatcaagt ggaaacgaggtctatgacgctgaatgcatgaagttaataaacgaatacttttatggcgtt cgtattaatcctggtcaggatcctacgcatgtttacgtcggttgggtaacaactcagtac cacttgcatagccgagaatttaatagtaagaaagtaaggaaaggttcagtgtttatcgaa gacgactatcagcaagtgatcgatcgtatagaccgtcaaagttgctacgttgttcgagca gatgaactgtataacgaagtgacacaagatgctaccggtaaaggggcaacacagggcatg tttgttggatgctttgtcgatacggcaatgggcgtcataagattcacatgcgaaggaaag gaaacgtcacatcgctggcaaatggagccggaaactaaactctttccagctattttcgta gaagcaacgagcaaggaaatcttacagattgagttgggtagaacgccaacaactttaccg ctatccgctgctgttttaccaaccagcgataagcacgtcaatccacagtttccacctcgt ctaaaggtgcaatgtctcaaacctcaccagtgggctagagtaccgaatcagttcttgcaa gtgcatgcactgaagttatcggatattcgaggatggtctatgttatgcgaagatcccgta tcaatgctggcattacatattccagaggaagatcgctgtgtagacatcttggaatcaatt gaaatggacaaattattgtcgttccattcccataccctaacattgtacgctgcactctgc taccaatcgaattatcgagcagctcatgcattgtgccttcacgtcgatcaaaagcaactg ctgtatgctatcaaatcggagtatatgtgtggaccgttgcggcaaggattctacgattta ttgattgccctgcatttggagtcgcatgctacaacaatggaggtgtgcaagaatgagttc atcgtgccactgggaccaggattgaaagagctgtaccgagacactgaaatgtgtcattca ttgcgatcgttgcaaaccgagtccgtgagacccatactaaggatgaccgatatagctgag ccacatttcctgccccactatacatccaatttagcaccggctgtttctagtgaccaaata ccgacgattgactcactctattcgccgaaatttgcgctcgaagtggtcagaacgtttgtg atggaagcgctcgccgaggccgtcgaagttaatcaggtccacaatcgtgatccgatcggt ggcagtaacgaaaatcttttactaccgttactcaaactgaccgacagactgttgttggtt ggaattttaaccgacgaagacatacagaaacttctgatcatgatcgatccagaaacgtgg gactctacgttcgacagagaaggtaaagacgaacatcgcaaaggtcttctcactatgaaa atggctgaaggagccaaactgcagatgtgctaccttttacatcatcttagcgatgtacaa ttacgtcatcgtgtcgaaagcattgttgccttctcgcatgattttgtcggtgatctccag gccgatcaactgcgtcgttatatcgaaattaaagcttccgatttgccgagtgctgttgca gctaaaaagacgcgtgaataccgttgcccaccgcgtgaacagatgaatgccattttggga ttcaaagacatggattcaactgatgttgagaattgcccatgtggtgtggatttacgcgac aatttcatgactttccatgagcaatttttgagtaaaatttcgttgaacgctctggaagag cccgaaccggaagaagaagtcgaagaagttccccagcccggaccattcactaagttctac aacttcattaatgtcaaagaagaggaacctgttgtcgagccagaagaaccggaaataaag actccggaggaattgttccgaaaagtattaatcaaaacgattattggttgggcgaaggaa tcacagattgaaatgccgaaactagtcagggaaatgttcagtttattggtgcgacagtat gataccgttggtgaaatgatccgagcattggagaggacctacgtcatcaacactaaaacc aaagctgatgttgctggtatgtgggtcggtttgagtcaaataagagcattactgccggta cagatgagtcaggaagaagaagaattgatgcgaaccagactgtggaggcttgtcaacaac cacacatttttccaacatccagacttgattcgtatattgcgcgtccacgaaaacgttatg gctgtaatgatgaacactttgggaagacgagctcagtccatcggtgatgcaccggttcaa agtgaaggaggtgaagcgccagtgaaagagaaagatacgtcacacgagatggtggtggct tgttgtcgcttcctttgttacttctgtcgtacaagtcgtcagaaccaaaaggctatgttc gatcactttgatttcttattagaaaattcgaacatcttactgtcacgtcccagtctgcgt ggatcaacgccgttagatgttgcctattcgagtttgatggaaaataccgaattggcactt gcactgcgtgaacattatttggaaaaaattgccgtttacctttcccggtgcggtcttcaa agtaactcagaactggtagagaaaggttatcccgatctcggatgggatccagttgaaggt gaacgatatctagattttctacggttctgcgtgtgggtgaacggtgaatcagtggaagag aatgccaatttagtaattcgattgctaatccgtcgcccagaatgtctgggaccagcactg cgcggtgaaggtgaaggcttacttcgtgctatcattgacgcaaataaaatgtccgagaga atctccgaacgacgcaaatatcacgaggaaccagaaagtgaaatggatgcagatttcgta catccactgcccgaaggtgaagaagacgaagattacattgacacgggagcggcaatactt ggtttctattgtactcttgttgatttattgggacgatgtgcaccggaaccctcagttatc gatctgggaaagaacgaatcgttgagagcgcgtgccattttaaggtctttagtaccactt gaagatttacaaggagtgttgggcttgaaatttactctgcaacaacaagcaccaggggaa gaaagacccaagtcagatgtgccgtctggtttacttccgggacacaagcaaagtattgtg ttgttcttggaacgtgtctatggcattgagacccatgagctattctttaagattttggaa gaagcatttttgccagacttgagggcggccacaatgctcgataaaaacgacggcagtgag agtgacatggctttgtccatgaatcgttacattggtatctccattctgccattgctcata aaacactctaggttctacagcgaagctgataactacgccagcttattagatgctgcactg cacactgtctatcgtttgtccaagaatcgaatgttaacaaaaggacagagagaagccgtt tctgacttcttagttgccctaacatcacaaatgcaacctgctatgctgttgaagctatta cggaagttaactgttgatgtgtccaagctatcagagtatacaactgtggcattgaggctc ttaactttgcattatgaacgctgtgccaaatactacgggtcgagccaggcccaaaccaca tacggtgcctcgtctgacgaagaaaaacgtctgacaatgatgctcttctcgaacatcttt gactcgttgagcaacatggaatacgatccggaattgttcggaaaagcgttaccatgttta atagccattggctgtgctctgccaccagactattcattgccacagaaaaacgatgacgat ccttacgacaacgctacaggaaaccctgataatccacaatacaacccgcagccaatcaac accagcaacattacgttggacaatgacctaaattcgattgtgcagaaattcagcgagcat taccacgatgcttgggccagtagaaagatggaggcacagtggcagtttggcgattcatgg tcggattcaagtaaaacacatccgcgattgaaaccgtacggcatgctgaatgattatgag cgagaacgatacaaggaaccggttcgtgactgtttgaaagctctattggctttgaattgg tccgttgaacattcagatgctgatgctccactatcccatcgtggatcaaccagacgacaa tcgaaaccaactgttgattttcaggcggaaggtagtaacgccttcgattacaatccacat ccggtggatatgactaatttgacactcagtcgagagatgcaaaatatggccgagagattg gcggaaaattcacacgacatatgggcgaaaaagaaacgcgaagaaatcgacacatccggt ggcataattcatcctcaattagttccctacgacttgttaacggacaaagagaaaaagaaa gatcgtgaaagatcgcaggagttccttaagtatatgcagtaccagggactcaagttgcac agaccatccaaagcaggcgtgggttcagtcgaaggtgaacctggtgtgattcaagcatcc attgaattgcgcttcgcctattctctgctggagaaattaattgcgtacttggatcgagcc acaatcaacatgaaaatgttacgaccatcagcaacgttcagcagacgaacgtcgtacaaa acggcctcacgcgacatcaaattcttttccaaagtcgttctacctctgatggaaaagtat ttctcgaccaatcgaggttatttcattgcggtcgcaacggccacgaacaacattggtgct gcctctctgaaagagaaggaaatggtggccgcgatattctgtaaattagctagtcttctc aggcatcgattatcggcatttgggcccgatgtccgtgtaacagtgcgctgtcttcaagta ttagtgaaagctatcgatgcgaaatcattaactaagaattgcccggaattcattcgaact tctatgctgacctatttcaacaacactgccgacgatttgggacagacgattgttaatcta caggatggtaaatttagtcatctccgcggcacccacttaaaaacctctacgtcattgacg tatgtgaaccaggtgatattgccggttcttacggctatgtttgatcacttagcatcatgt gattatggtagcgacatgctcttggatgaaattcaagtagcttcctataagatcttagcg gctctgtacactctgggaatagatccaacactgaccaatgatcgcaaatacttaaaaaca gaaatcgagcggaataaaccgagtctcggctcctgtctgggatcgttcagttcaacattt ccagttgcctatttggaacctcatctaaacaaacacaatccattttcactgctgaatcgc attgctgatcattccctagaagctcaggatataatggtcaaaatggaaagttccatgcca aatctggaaacgatcatggccgaagtcgatcagtttgttgattccgataaaacgtacaac gactcaccgcacatcatcgacgttatattgccgctactgtgttcatatctaccgttttgg tggtcacaaggtccagacaacgtatcgccaacgaacgacaaccacgttacgatggtaaca gccgaccatatgaaccatttgctgaccaacgttttgaaattaatcaaaaaaaatatcggc aacgaaaatgccccatggatgactagaattgcagcgtacacgcaacagatcatcatcaat agttccgaggaattgttggtggacgtgtttctgccgttagccgaacggatgaagaaacgg acggaaaatatgttccacaaagaggaaagtatgcgaggatttatcaagtcagctgcagac gatacgtcacaggtggaaggtcaaatacagaccgattggcaactgctggttcgagacata tactcgttctatccgttgctgatcaaatatgttgacttgcaacgtaatcactggctgaaa aacaatattcacgaggctgaagaactgtacaatcatgtcgctgaaatattcaacatctgg tcaaagagtcaatacttcctgaaggaagagcaaaacttcatttcggccaacgaaatcgac aatatggcgctgatcatgccaacggccacaagacgtggtgctaatgtgaatgaaggcgcg cccgtaactggaggtaaggtcaaaaagaagaaaaagaatcgtgacaagaaacgcgacaag agtaaggaagtgcaggctagcttaatggttgcctgtctgaaacgtttacttcctgtcggt ttgaatttgttcgctggaagagaacaggaattggttcaacactgtaaggatcgctactta aagaaaatgcttgaaacggacgtcattgaatttgccagaactcaattaacactgccggac aaactcgatcctgcggatgaaatgtcgtggcaacattatttgtactcgaagttgggtaag aaggaatcagagcctgacgatacaagtgaaaaactaccaacaccagcaacagcgattgag aaaactaaagagaaaataattgaggaaacggccgaccgaattgtggctatggcgaaagta ttattcggactgcatatgattgatcatcctcaacaacaaagcaaaaatgtttatcgcagt gtcgtatcgattcagagaaaacgagcagttattgcttgcttccgacaggcaacacttcat tcactgcccagacatcgagcctgtaatatattcgctcggacatactttgaaatttggttg ggagcagaaaatgtcggacaagaggttatgattaacgatctaacacaatcatttgaagaa gctgaaaagcagagaaagctgggtgatgaaccagttgcgaaaccggatccattgtcgcaa ttggtcgtaacattttgccgtggagcaatgacagaacgaagtggtgctttacaggaagat ccgttgtacatgtcctatgctcacattgtagctaaatcgtgtggcgaagaagcagaggaa gaagaagaggaagagagcgaagaaggagagagaagtgccattcatttttctatggaaata ttctggcgacaagaaatggaaaaacagaaacttctttacgctcaaaagcgcctaaacaaa cgaggtgtctccgaaatggtgctgttgcatatatctgcctctaagggcataccatcagaa atggtaatgacaacgctacagcttggtatctctatattacgcggtggtaacatcgacaac caaatgggtatgctcaaccacctcaaagacaagaaagatgtaggctttttcacagcaatt gctggattgatgaactcttgtagtgtgcttgacttggacgcgtttgaacgaaataccaaa gcagaagtgtatacgtcgagtatgggttcaggtttaggctgtgggtcggaaggagccgct ggcgagaagaatatgcacgatgctgaatttacttgcgctctatttcgtttcattcaattg acgtgcgaaggacacaatttagaatggcaaaactatttacgaacacaggccggtaacaca accacagtgaatgttgttatttgcacggtcgattacttgctacgtttacaggagtctatc atggatttctattggcattattcaagcaaggaagtaattgatacagctggtaaagcgaat ttcttcaaagcaattggtgtagcaagtcaagtctttaacacgttgactgaagtcatccaa ggtccttgtttactgaatcaacaagcattggcacattccagattgtgggatgctgtctgt ggtttcctgttcttgttctcacatatgcaaaacaaactatcgagacattctagtcaaaat gacttattgactgagttgaataacttacagaaagacatgattaccatgatgttgtctatg ctagaaggaaatgttatcaatggtaccattggtaaacagatggtcgacacattggtcgag tccgcctcgaatgtggaactaattctgaaatatttcgacatgtttttgaagctcaaagac ttgatttcatcaccatcgttccttgagatcgatcacaatatggatggttgggtgttcccc aaagatcttaaagaaaaaatggagctgacaaagaattatacaccggaagaaatcgagttc attctcgtttgcatggaagtgaatcatgaaggtaaagtggactacgaaacgttcagcgat cgattccatgaatcagccaaagacattggcttcaatttagcgatgctgttgacgaatctg tcggagcatatgcccaatgaaccaagaattgcacggttccttgaaacagctggttcagtt ttgagctattttgaaccgttcatgggacgtatcgaaattatgggcggctccaaacgcatc gaaagagtctacttcgaaataaaggaatcgaacattgatcagtgggagaaaccgcaaatc aaagagtcgaagcgagcctttttctactcgatggtgactgagggcggtgacaaagaaaaa ctggagtcattcgtcaatttttgtgaagatgcggtctttgaaatgcaacacgcgtctggt ttaatgtccactgatgatggcagcagtaccacaaggaaagaagctcagtataccttcatg agtgaggaagacgaggaacgagccgctaaggacccgattcgacgtagtgtacaggcagtc aaagatggattccattatgctattcatatgttcagtcctgctaatatcaaatatcaaata ggcgtcatgcagacgatgtccatacccgaattgataattggcttcttcaaaacatttttc tacgccttttactattcgggtttcggtgtttcacaggtcataaaatacatcttcggcatt cttatgtcgttgatgcgtggcccggctgaagaatatgttcaaatagtgccgattgaagaa gagaaaacgatgagagctctgccagccctaccatccgaagagacaacgggaacggtgtca gcatttggtttagatataagtaaagaagacactggtcaatacagaatcgctccgcatgaa tccaatcaaccgagtccaacgtcatctatggaagaaaccggtgaaagtggtccggatgat gcttcgccgactggtgaactgaaagccgacggagaaccagttgaacagccaatgacttta gtagatttattgggaggtgacgcagcgaaacgtgccgatcaagaacgcagtgaagctcag aaaatacaggaagctgctatggcctcaatcgaagctgaagccaaaagatcgactgagacc caagctgaaccagcagctgtggcacaaatcgacgtttcgcattatacacataaagtagtg agcttcttagccagaaacttttacaatctcaaatatgttgcgttgattttggccttctgc atcaacttcatgctactgttctataaagtcaatgtatttggtgaggacggcgacggtgat ggtgatgacgatttgattggatttggttcgggatctggaagtggttttggtggctcaggt tcaggaagcggcgatggcgatgatgaagacgaggatgcactggaaactgttatagttaat gaggacttcttttacatggaacatgttatacgtttggctgcgttcctgcacagcttatgt tcgttggccatgcttattgcctactatcatctcaaagttccgttggccattttcaagaga gaaaaggaaatcgctcgtcggttagagttcgacggtctcttcatagccgaacagcctgag gacgacgatattaaatcgcattgggataagttggtgatatcaacgaaaagtttcccagtc aattattgggacaaatttgtgaaaaagaaggtgcggcagaagtactgtgagacgtacgac tatgattcgatatcaaatctgcttggaatggaaaagaatgtgtataagaccggtcccgaa gtagaggaacaaaccggtctgattgcctacattttgaatattgattggcgctacaatgtc tggaaggctggtgtaaccattaccgacaatgcgttcttgtacgctctgtggtacttctgc ttttcactactcggaaatttcaacaatttcttctttgccgcccatttgctcgatattgcc gtggtaattccgtcgttgaaaaccattttgcaatcagtaacgcacaacggaaaacagcta atgttaacggtgatgctgttaaccatcatcgtctacatttacacggtcatcgcgttcaat ttcttccgcaaattctacatccaagaggaggacgacgaagtggacaaaaaatgccacgac atgatgacctgtttcgtgttccatctgtacaaaggtgtacgagccggcggtggcatcggt gacgaaatcggcgatcccgtcggcgatgactacgaagtgtatcgaatcctattcgacata acattcttcttctttgtcattgtcattctgctggccatcattcaaggtttgattatcgac gcgttcggcgaactgcgtgaccaattggaaagtgtcaaggaggacatggagtcgaattgc ttcatttgcggcatcgggaaggattactttgataaagtgccgcacggattcgatacgcat gtgcagcaagagcacaatctggccaattacatgttcttcttgatgcatttgattaacaaa ccggatacggagtttacgggccaagagacgtacgtgtggaatatgtatcagcaacgatgt tgggacttctttccggtcggtgattgtttcaggaaacagtatgaagacgaactgggtatt ggtggcggtggttaa

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