KEGG   Brevibacillus formosus: BP422_09180
Entry
BP422_09180       CDS       T04939                                 
Name
(GenBank) non-ribosomal peptide synthetase
  KO
K16124  tyrocidine synthetase III
Organism
bfm  Brevibacillus formosus
Pathway
bfm01054  Nonribosomal peptide structures
Brite
KEGG Orthology (KO) [BR:bfm00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01054 Nonribosomal peptide structures
    BP422_09180
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins [BR:bfm01008]
    BP422_09180
Polyketide biosynthesis proteins [BR:bfm01008]
 Nonribosomal peptide synthetase (NRPS)
  Linear NRPS
   Tyrocidine synthetase
    BP422_09180
SSDB
Motif
Pfam: Condensation AMP-binding PP-binding AMP-binding_C Thioesterase
Other DBs
NCBI-ProteinID: ASJ53710
UniProt: A0A220MGQ3
LinkDB
Position
1908225..1927688
AA seq 6487 aa
MNKQENIAKIYPLTPLQEGMLFHAVKDTDSSAYCLQMSAKLQGDFHLPIFEESMNKLVEN
YEVLRTVFVYQNLQRPRQVVFKERKVTVHFENIAHLPIDDQNDYIKAYTSQHHTFELTKD
VLMKAAIFQTGENQYQFVWAFHHIIVDGWSLGVLLHKLLAYYAAIRKGEAVPREATKPYS
EYIKWLDKQNKEEALTYWQNYLEGYDHQADFPKKKNVAEDGSYVHVENLFTIAPEKTQQL
MQIANQNQATMSSVFQSLWGILASKYKNSDDVVFGSVVSGRPPGIQGIESMVGLFINTIP
TRVQTNRKQTFSGLLKTVQKQALASASYDFAPLYEIQSKTVLKQELIDHLVTYENYPDHA
LSDREDSLGFQFNVENGEEQTSYDFNVVVAVAPSNEMYVKLSYNAAVYEESFMNRVEGHL
KTIIEQVIVNPNVLLEDIGIITDEEKQQLLVAYNDTTADYPRDKMIFELIAEQARQTPSK
VAVVCGEDRLTYQELQERSNQLARALRGKGITQGSIVAIMAEHSLELIVAILAVLKSGGA
YLPIDPEYPIERIQYLLDDSQTTILLTQSHLQEKGEFEGDILYLDNPSLFEGDSTDLDNS
CTTDDLAYMIYTSGSTGNPKGAMITHQGLVNYIWWANKVYVQGEAVDFPLYSSISFDLTV
TSIFTPLLSGNTIYVYRGADKVQVILDIIQDNQVGIIKLTPTHLKLIEEIDGTNSSIRRF
IVGGENLPTQLAKRIYENFGQNVKIFNEYGPTETVVGCMIYLYDPEKTIQESVPIGIPAD
NVQLYLLDSSMQPIPVGSIGEMYISGDGVAKGYFNRPELTQEKFIDNPFRPGTKMYRTGD
LAKWLPDGNMEYLGRIDHQVKIRGHRIEMGEIETRLTQHEWIKEAVVIAEKDDSGQNVLY
AYIVSEQELTVSELREHLGSTLPSYMIPSFFVRLEEIPLTANGKVERKKLPKPDGAVVTG
TAYVAPQNETETKLAEIWQQVLGVSRVGVHDHFFDLGGHSLKAMTVIFQVSKALEVDLPV
KALFENPTVSELAAFISKSGKSKYTAIQPVEVKEFYPVSSAQKRMYILQQFEGSGISYNI
SGAMLLEGKLDYDRFASTVQRLAERHEALRTSFHRIDGEPVQKVHDEVEVPILMLKSTED
KAEQIMRDFVRPFDLGIAPLIRTGLVQLGKDRHLFLLDMHHIISDGVSSQILLTEFAKLY
QGEALQPLPLQYKDFAAWQNELFQTDVYKKQELHWLNTFADEIPLLNLPTDYPRPSIQSF
EGDLVLFDTGKELTERLRKVATDTGTTLYMVLLAAYHVLLSKYSGQEDIIVGTPVAGRSH
ADVQNIMGIFVNTLAMRNQPVSDKTFTQFLQEVKQNALASFDNQDYPFEELVEKLAIQRD
ISRNPLFDTMFSLENANQQSLEIEQLTAAPYELFNKISKFDLALNASESQSDIQFQFAFG
TKLFKKETIQRMAHHYLEILHTISAQPNAKLAEIDMMTEAEKRALILNVNDTFVERSADQ
VLHQLFEEQVVLTPDQVAVAYDGYTLTYRQLNARANQVARLLRSKGTQPDTLIGIMVDRS
IGMVVSMLAVLKAGGAYTPIDPTYPPERIQYMLSDSKAPILLTQRHLKETVEYAGEIIDV
DDEAIYAGDDTNLDNVAGRDDLAYVIYTSGSTGNPKGVMIAHQAICNHMLWMKNAFPLGT
EDAVLQKTPFSFDASVWEFYLPLITGGRLVLAKPDGHRDIEYMTRMIREEKITTLQMVPS
LLDLIMTEPGWSSCTSLQRVFCGGEALAPALVSRFYQTQTAQLINLYGPTESTIDATYWI
CPRLPEYGVIPIGKPIDNVRLYVVNASNQLQPVGVAGELCIAGDGLARGYWNREELTTAS
FIDNPFEPGSRMYRTGDMVRYLADGNVEYLGRIDHQVKIRGHRIELGEIEARLLQHEWIK
TAIVLARPDEKGQNNLYAYIVSDQEIKTADLRAYMASHLPAYMVPSYFVYLEKLPLTANG
KVDRKALPQPEGATSSEAVFVAPRNEVEATLADIWQSVLGVNPIGVHDHFFELGGHSLKA
MNVISLIHRTLQVDVPLKTLFESPTIADLSAYIATAGKGKYTTIEPVQKQEYYSVSSAQK
RMFILRQMEGAGISYNMPGLLYIDGKLDTERLQQALKSLVRRHESLRTSFHSMKGETVQR
VHEDVELEISLMESTEGELKQIVEQFIQPFDLEKAPLMRAGLVKLAPERQLFMLDFHHIV
VDGVSIGILVQELAQLYHGEELPELNIQYKDFAHWQNQWFETEEFAAQEAYWIDTFTGEI
PVLNLATDYPRPSVKSFEGERFVFGSGALLKKELNRLAQGTGATLYMVLLAAYNVLLSKY
SGQEDIIVGAPTAGRSHAETDSIIGMFVNTLALRNEPVGAKTFLSFLAEVKNNTLKAFEN
QDYPLDELIDKLNIQRDLSRNPMFDTVFILQNMDQKPFEMEQLTFTPYMAEVNQAKFDLS
LEAYEEDEEIVFSLDYCTKLFTRKTIEKIAAHFIRILHAVIEQQAITLSEITMLSDEEKH
RLLVEFNQTHTEYPQNKTLHELFEEQVEKTPLVAAVEIGDKQMSYRELNERANQLAVTLR
ERGVKANQFVGIMANRSVEMVVGIMAILKAGGAYVPIDPEYPEDRVAYMLEDCDARLVLT
QKHLGAKLASSVRVECLYLEEEKNYSPNRSNLEPIQTASDLAYIIYTSGTTGKPKGVMIE
HRGIVNSVLWKKEEYQFSVQDRNLVPLSFAFDGFVLSFFTPILSGSTAVLAKDEEAKDPV
SLRRLIAAARCTQMTCVPSLFQAILECGSAADISSLQIVTLGGEKVSAQLVEMSNQQNPQ
LVIANEYGPTESSVVATRQRISQLDSTITIGRPIANTSIYIVDKFHQLQPIGVVGEICIG
GHGLARGYWNKPELTAEKFVSHPYLEGERMYKTGDLGKWLPDGTIEFIGRLDEQVKIRGY
RIEIGEIESVMLSFEKLTSAVVIVHEDQQGQSSLAAYFTAEEKLEVSNLWTYLSQSLPSY
MIPAYLIQLNHLPLTPNGKIDRKALPKPEGRPVMGAEYVAPASPVESRLVEIWEQVLGLS
EIGVLDNFFQLGGHSLKAMSLAAQIHREYQVELPLRVLFATPTIQALAQHIETSGKDTHV
PIQPVPQQEYYPVSSAQKRMFVLRQFEGTGTVYNMPSVMFIEGDLDLARFETAIQGLVKR
HESLRTSFHTVNGEPVQRVHEAVELDVRYENLTEDQVEQTIESFVQAFDLEKAPLLRVGL
FRLGENRHLFLMDMHHIISDGVSVGIIMEEFSKLYRNEYLPELTVQYKDFAVWQTDLFQT
DIYTKNENYWLKSFAGDIPVLNLPADYSRPLVQSFEGDCITFQTDKTLMDDLYKLAHENQ
TTLFMVLLAAYNVLLSKYSGQEDIVVGTPIAGRSHADVEKVLGMFVNTLALRNYPEGTKS
FHAFLEDVKQNTLQAYAHQDYPFEALVEKLEIQRDLSRNPLFDTMFILQNLDKKAYELDG
LKFEAYSGDGQQGNAKFDLTLEAHEDETGIHFGLVYSTKLFQRDTMERMAGHFLQVLRGV
IADQTAALHEINLLGEEEKHLVTVAFNNTFAAYPRESTIQELFEEQVERTPEHTAVVMNE
QMLTYRELNQKANQIASALRRLEVGRDSVVGLLADRSLEMITGIMGIIKAGGAYLGIDPE
HPAERISYMLEDGGVKVVLVQRHLLHLVEEGLIPIVLEDESLEQEDGSNLTNLNGAKDLA
YVMYTSGSTGKPKGVMVEHRNVTRLVIHTNYVQVREEDRMIQTGAIGFDAMTFEIFGALL
HGASLFLVSKDVLLDAEKLGSFLRENRITTMWLTSPLFNQLSQDNPAMFEGLRALIVGGE
ALSPRHINKVNSAHPALEIWNGYGPTENTTFSTCYLIEKEFEDNIPIGKPITNSTAYIVD
RYNQPQPIGVPGELCVGGDGVARGYLNKPELTAEMFVPNPFVSGENMYRTGDLARWKADG
TIEYLGRIDQQVKVRGYRIELGEIESVLTKLEKVKEAVVTVMDDTNGQKALCAYFVPEEE
FDVAELREAISKELPSYMVPSFYVQMDRLPLTANGKVNRRALPEPSGDRVQGSTYVAPRN
ATEQKLAEIWQEVLGIHPIGIHDNFFELGGHSLKAMNVITQVHKAFQVELPLKALFESPT
ILELATYITASEIEQFETIQPVEQADFYPVSFAQKRMYILHEFEGSGISYNVPNVLIIDG
KLDYERFEHAIRTLVKRHESLRTSFHSKNGEPVQRIHEDVTLLIGISEATEDQVEQRIQE
LVQSFDLEVAPLFRVHLIKLGAERHLFFMDMHHIISDGVSLAVIAKEFASLYEEKQLPDM
RIQYKDFAAWQTKLSQSERFQKQEDYWTNVFAGEIPLLNLPNDFPRPTVQSFEGDTVAIG
TGNHLLAELRQLAANTGSTLFMVLLAAYNVLLSKYAGQEEIVVGTPIAGRSHADVERIVG
MFVNTLALKNVAGGNLTFREFLGDVKQNALHAFEHQDYPFEHLVDKLQVRRDLSRNPLFD
TMFSLGLADSSALEIAGLNMSAYPVDGKIAKFDIALDAMEQQDELLVQFNYCTKLFAKES
IDRMATHYVNLLQTIIANPDCKLAEINVLSKDEIEQMLHDFNATKAAYPTNKTFQELFEE
QVEKTPNQVAVIFEDEQLTYRELNEKANQLARVLRQMGVKPESTVGIMVDRSLHMVVGTL
GILKAGGAYVPIDPDYPLERQAFILEDSDAKLFLTLQKMNTQLAFPHETLYLDAEGLYQG
EASNLEPVALPEHAAYIIYTSGTTGKPKGVVIEHRSYANVAFAWQDEYHLDTFPVRLLQM
ASFAFDVSTGDFARALLTGGQLVICPNEVKMDPASLYEIIKRYEITIFEATPALIMPLMH
YIYENKLDISQMKLLILGADSCPAEDFKTLLARFSQTMRIVNSYGVTEACIDSSYYEETD
VSSIRSGTVPIGKPLPNMQMYVMDPQLNLQPVGVVGELCIGGEGVARGYLNRPELTQEKF
VPNPFAPGELLYRTGDLAKWRADGNVEFLGRNDHQVKIRGVRIELGEIETQLRKLDGILE
AVVVAREDHRQEKYLCAYMVAEHEIDTAHVRKELLKELPQAMIPSYFVTLEALPLTANGK
IDRRSLPAPDVSLLRTTEYVAPRTELETQLARVWEQVLNVEQVGVLDDFFAIGGHSLRAM
SVISSMHNEYQVDIPLRILFEKPTIQQLAAHIEETVRGHVISIQPAPAQEYYPVSSAQKR
MYILHQFEGVGISYNMPSTMLIEGKLEPERLETAFKQLIARHESLRTSFAVVNGEPVQKV
HEEVSFELSYTTITEDQAHEVLSSLVQPFDLGIAPLLRARLLHIGEDRHVLFTDMHHSIS
DGVSSGILLSDLVKLYQGDVLPELRIQYKDFSVWQQELFRSDAFNNQEEYWAQVFADDIP
VLNLQTDFTRPSIQNFAGDQYAIGTGQQLMEGLNQLARETGTTLYMVLLATYNVLLSKYS
GQEDIIVGTPITGRSHADLEPIVGMFVNTLAMRNKPHAGKTFTELLLEVKQNALDAYAHQ
DYPFEELVEKLDIPRDLSRNPLFDTMFTVQNNTDESIDLLGLTLAPFMTDQAGNHSKFDL
TVIATEEREEIRIGVEYSTSLFTRETIERLSNHFMAIAQIIVQNPNIRLSEIDMLSAEEK
QQIFEKFNDTAVSYVQDKTLHQLFEEQVAKTPNQEAILFNGQSLTYSELNERANRLARVL
RTKGVGPDRLVAVMAERSPEMIIGILGILKAGGAYVPIDPAYPQERIQYLLADSNAALLL
CQSHLSELLSRVSSGLDWLDLNAEHDDEMDGSNLSSLNQPTDLAYVIYTSGTTGKPKGVM
IPHQGIVNCLQWRRDEYGFGPGDKALQVFSFAFDGFVASLFAPLLGGATCVLPREEEAKD
PVALKKLIASTGVTHYYGVPSLFQAILDCSTAADFSPLRCVTLGGEKLPPQLVQKTKEKH
PAIEINNEYGPTENSVVTTISRSIEAGQNITIGRPLANVQVYIVDTQHHLQPIGVVGELC
IGGPGLARGYLNKPELTQEKFVPNPFVPGELMYKTGDLVKWRTDGTIDYIGRADEQVKVR
GYRIEIGEIESTILAYDGIDQAVVVVQEDELTAGQYLCAYLVTAAEVSVSELRRHLAKEL
PAYMVPSYFVQLDQLPLSANGKVDRKALPKPQSSDATTREFVAPRNATEHQLASIWQEVL
GIEPIGITDHFFELGGHSLKATLLVAKVYEYMQIELPLNLIFQHPTIEKVADFITHKNFE
GNSGRSILLNEETARKVFCFTPIGAQSVYYQKLADEIKGVSLYSFDFIEEDNRLEQYIEA
IVAIDPKGPYMLMGYSSGGNLAFDVAKELENQGYVVTDLILFDSYWKDKVMERTLAETES
DITQLFAEIGENIEMFNMTQEDFNLYAANEFVKQSFIRKTVSYVMHHNQLINSGATNAAI
HLIQSELESGEEDLVAVKWNEAAWAQATKRLMTYEGYGIHSRMLGGNYVSMNASILRDIL
QELFILK
NT seq 19464 nt   +upstreamnt  +downstreamnt
atgaataagcaggaaaatattgcaaaaatttacccgttaaccccattgcaagagggtatg
ttgtttcatgctgtcaaagacacagacagcagcgcctactgcctccagatgtccgcaaag
ctccaaggtgattttcacctgcccatttttgaagagagcatgaacaagctcgtagagaac
tatgaagttttgcgtactgtgtttgtttatcaaaacctacagcgacctcgacaggttgtt
tttaaagagagaaaagttaccgttcatttcgaaaacattgctcatttgccaatagatgat
cagaacgattacataaaagcgtataccagccagcatcatacgtttgagctaacgaaagac
gtcttgatgaaagcggccattttccaaacgggggagaaccagtatcagttcgtttgggca
ttccaccatatcatcgtcgacggttggtctttgggcgtattgcttcataagctactcgcg
tactatgccgccattcgtaagggcgaggctgttccgcgggaagcgaccaaaccatacagc
gaatatatcaaatggctggataagcaaaacaaagaagaagcacttacttactggcagaac
tacctggaaggctatgaccatcaagctgatttccccaaaaagaagaatgtagcggaagat
ggcagttatgtacatgtggagaatcttttcaccatcgcacccgaaaagactcaacagcta
atgcagattgccaatcagaatcaggctacgatgagcagtgtatttcaatctctttggggt
attttggcgagcaagtacaaaaattcggacgatgtggtattcggttctgttgtgtcaggt
cgtccgccagggatccaggggattgagagcatggttggattgttcattaacacaatccca
acccgcgtgcaaacgaacagaaaacaaaccttcagtgggctgttaaaaacagttcagaag
caagccttggcttctgcttcttatgatttcgctccgctgtacgaaattcagagcaagacg
gtattgaaacaggagctaatcgaccatttggtgacgtatgaaaactatccagatcatgct
ttgagtgatcgggaggattccttaggctttcaattcaacgtggaaaatggggaagaacag
acttcctatgattttaacgttgtggtagcagtggcaccttcgaatgagatgtatgtgaag
ttgagttataatgcagcggtttatgaagagtcattcatgaaccgagtagaaggtcacttg
aaaacgatcattgagcaggtcattgtcaatccgaatgtactgctcgaagacatcggaatc
atcacggatgaggaaaaacagcaattgctggtagcatataacgacacgaccgccgattat
ccacgcgacaaaatgatttttgagctgatcgcggagcaggcaagacagacgccttcgaaa
gttgcggttgtttgcggtgaagatcgccttacttaccaggagcttcaggagcgttccaac
cagttggccagagctctgcgtgggaaaggaattacccaaggcagtatcgtcgccattatg
gcggagcattcactcgagctgatcgtggctattttggcagttctaaaatcaggcggcgcc
tatttgccgattgatcccgagtatccgatagagagaattcagtatttactggatgacagt
cagacgacgattctcttgacacagtctcatcttcaagaaaaaggcgagtttgaaggcgac
atcctctacctagacaatccttccttgtttgaaggagacagtacagatcttgacaattca
tgcacaacggacgatttggcgtacatgatctatacttccgggtccacggggaatccaaaa
ggcgcgatgattacgcaccaaggtctagtcaattacatttggtgggccaacaaggtgtat
gtccaaggggaagctgtagactttccgctatactcttccatttcgtttgatttgactgtc
acctcaatcttcacgccgcttctgtcaggcaatacgatctatgtctacagaggagcagat
aaggtacaggtcattttagacatcatccaagataatcaagtgggaatcatcaagttgacg
ccaacacatttgaaactgattgaagaaatagatggaacaaacagcagcatccgacggttt
attgtcggtggtgagaacttgccaacccaattggcgaagagaatctatgagaactttgga
cagaatgtcaagattttcaatgagtatggacctaccgaaacggttgtgggctgcatgatt
tacttgtatgacccggagaaaacgatccaagaatcagtaccaatcggaatccctgccgac
aacgtccagctttatttgctcgattcctctatgcagccgatacccgttggctccattggt
gaaatgtatatatccggagatggcgtagccaaaggatatttcaatagaccagagctgaca
caggaaaagttcattgataacccgttccgtccggggaccaaaatgtatcgaactggcgat
ctggcgaaatggctgcccgacggcaatatggaatacttgggaagaatcgaccatcaagtc
aaaattcgtgggcatcggattgagatgggtgaaattgagacgcgtttgacgcagcatgaa
tggatcaaggaagccgtcgtcatcgctgaaaaggatgacagtggtcaaaatgtgctctat
gcctacattgtttccgagcaggagttgaccgtatcggaactacgagagcatctgggaagt
acgcttccttcctacatgatcccgtccttctttgtccgtctggaggaaattccgctgaca
gccaatggaaaagtagagcggaagaaattgccgaagcctgacggtgcagttgtaacggga
acagcgtacgtcgctcctcagaatgaaacggaaacaaaattggctgagatttggcagcag
gtcctgggggttagccgtgtaggcgttcacgatcatttctttgatttgggcggacattca
ctaaaggctatgacagttatctttcaagtctccaaggcgttggaagtggatttgccagta
aaggcactgttcgagaatccgaccgtatccgagctcgctgcctttatctcgaaatcgggg
aaaagcaagtacacagccattcaaccggttgaggtcaaagaattttatcccgtatcttct
gctcaaaaaagaatgtatattcttcagcaatttgaaggaagcggaatcagttataacatt
tcgggtgcaatgttgttagaaggaaagctggattacgatcgttttgcgagcacggtccaa
cgactggcggagcgccacgaagccttgcgcacctccttccaccggatcgatggtgaacct
gtacagaaagtccatgatgaggtagaagtaccaatcctgatgctgaagtctacggaagac
aaggcggagcagatcatgcgtgatttcgtccgtccttttgatctcggaatcgctccgttg
attcgaacaggcttggtccagttgggcaaagaccgtcatttgttcctgctcgacatgcac
catatcatctcggacggtgtttcgtcccaaattttgctgactgaatttgccaagttgtat
caaggagaagccttgcagcctctacctctccaatacaaggatttcgctgcttggcaaaat
gagctgttccagacggacgtgtacaagaagcaggagctccactggttgaatacgtttgct
gatgaaattcctttgctcaatctgccgactgattatccgcgtccatccattcaaagcttt
gaaggggatcttgtcctttttgatacaggaaaagaattgacggagcgtttgcgcaaggtt
gcaacagatacgggaacaaccctgtatatggtcttgctcgcggcttaccatgttctcctg
tccaagtattccggccaagaggatattattgtgggtacgcctgtcgctggtcgttcccat
gccgatgtgcaaaacatcatggggatctttgtgaatacgttggcgatgagaaatcagcct
gtgagcgacaaaacatttacccaattcttgcaagaagtaaaacaaaatgcgctggcatcc
tttgacaatcaggattatccatttgaagaactggtggaaaagctggccattcaacgtgat
attagccgaaatcctttgtttgacaccatgttttctttggaaaatgcgaatcagcagtcg
ctggaaatcgagcagcttacagcagctccgtatgagttatttaacaaaatttcaaagttc
gatctggctttgaatgcgagtgaatcgcaatccgacattcaattccaattcgcatttgga
acgaagctgttcaagaaagaaaccatccaaagaatggcccatcattatttggaaatcttg
cataccattagtgcacagccgaatgccaagttagcagaaatcgacatgatgacagaagca
gaaaaacgtgctctcatcctgaatgtcaacgatacttttgtcgaacgttccgctgatcag
gttttgcatcaattgtttgaagagcaagtagtgcttacgccagatcaagtagctgtagcc
tatgacggatacaccttgacctatcgccagttgaacgcccgggccaatcaagtagctcgt
ttgctgcggagcaaaggaacgcaaccggatacgttgatcggaattatggtagaccgttcc
atcgggatggtcgtgagtatgttggctgtcttaaaagcaggtggtgcgtatacgccaatt
gatcctacctacccgccagaaagaatccaatacatgctcagcgacagcaaagctcccatt
ctactgacacagcgtcatttgaaagagacagtagagtatgcaggagaaatcatcgacgta
gacgatgaagcgatttatgcaggtgacgacaccaatcttgacaatgtcgctggcagggat
gacttggcctatgtcatctatacatctggatcgaccggaaatcccaaaggggtcatgatc
gcgcatcaagcgatttgcaatcacatgctttggatgaagaatgccttcccactgggtaca
gaagatgctgtcttgcaaaaaacaccgttttccttcgatgcttctgtatgggaattttat
ttgcctctgatcacggggggacgcctggtactggcaaagccagacggacatcgcgacatc
gagtacatgactcgcatgatcagggaagagaagatcacaactttacagatggttccttcc
ttgctggacctgatcatgaccgaaccgggatggagctcttgcacgagcttgcaacgcgtt
ttctgcggtggagaagcattggcacctgcacttgtttcgcgcttttaccagacgcaaacg
gcccagttgattaacctctatggccctacagaatcaacgattgatgcgacatactggatt
tgccctcgcttgccggagtatggcgtgattcccattggcaaaccgattgataacgtccgt
ttgtacgttgtgaatgcgagcaaccagctccagccagtaggggttgcaggagaactgtgc
attgctggcgatggtctggcccgcggctactggaatcgtgaagaactgacaacagccagc
ttcattgacaatccgtttgaaccgggtagcaggatgtaccgcactggagacatggtaagg
tacctagccgacggcaacgtggaatatctcggacgcatcgaccatcaggtcaaaatcaga
ggccaccggatcgaactgggtgagatcgaagcaaggcttttgcagcatgaatggataaaa
acggccattgtccttgcccgtccagatgaaaaagggcaaaacaacttgtacgcctatatc
gtttccgatcaggaaatcaagacagccgacctgagagcttacatggcttcccatttgcca
gcttatatggttccttcttattttgtttatttggagaagctgccgcttacagcaaatggc
aaggtggatcgcaaagcattgcctcaacctgagggagcaacctcatctgaagccgtgttt
gtagcgccgcgcaatgaagtggaagccacgctcgcagacatttggcaaagtgtacttggc
gtgaacccaatcggagtacacgatcatttcttcgagttgggcggacattctttgaaggcg
atgaacgtcatctctttgatccatcgtactcttcaagtagatgtgccgttgaaaacactg
tttgaatcgcctacgattgctgatttgtcggcatacatcgctactgctggcaaaggaaag
tatacgacgatagaacctgttcaaaagcaggagtattactccgtgtcttctgcacaaaag
agaatgtttattctccgacaaatggaaggtgcaggtatcagctacaacatgccgggcctc
ttgtacatcgatggcaagctggatacagagcgtttgcagcaagcgctcaagagtttggtg
agacgccatgaatctctccgtacctcgttccattccatgaaaggagagactgttcagcgc
gtacatgaagatgtcgagctggaaatctcgttgatggagtcaacagagggcgagctcaaa
caaatcgtcgagcaatttattcaaccgttcgatttggaaaaagctccactgatgcgcgct
ggactggtcaaactggctccggaacgccagcttttcatgctggattttcaccatattgtc
gtggatggtgtatcgattggtattctagttcaagagcttgctcagctttatcacggggaa
gagctgccagaactgaacattcagtacaaggactttgcccattggcagaatcaatggttc
gagacggaagagtttgctgctcaggaagcctattggatcgatacctttacgggagaaatt
cctgtattgaatcttgcaacggattatccgagaccttctgtgaaaagcttcgagggtgag
cgttttgttttcggctccggtgcccttttgaaaaaagaactgaatcgacttgcccaaggt
acaggagctacgctctacatggttttgctggcggcctacaatgtacttctctccaaatac
tctggacaagaggacattattgttggtgcgcctactgctggcaggtcccatgcagaaacg
gattcgatcatcggtatgtttgtcaatacactggcattgcgaaacgagcctgtgggagct
aagaccttccttagctttttggcagaagtaaaaaacaatacgctgaaagcctttgagaat
caggattatccactggatgagctgatcgataagctgaacattcaacgagatctgagccgc
aatcctatgtttgacaccgtatttatcttgcaaaatatggatcagaagccgttcgaaatg
gagcaactaacgtttacaccctatatggcagaagtgaatcaggccaagtttgatctgtca
ttagaggcgtacgaagaagatgaggagatcgtctttagtcttgattactgcaccaaattg
tttacacgaaaaacgattgaaaaaatagcggcacatttcatccgaatccttcatgccgtt
attgagcaacaagccattacgttgtccgaaatcactatgctttctgatgaagaaaagcat
cgcttgttagtagaattcaaccaaacgcatacggaatatccgcagaacaagacactacat
gagctgtttgaggagcaagtagaaaaaacaccactggttgctgcggttgaaattggcgat
aagcagatgtcctatcgcgaattgaatgagcgagcaaaccagcttgccgttaccttgcgt
gaacggggagtaaaggctaaccaattcgtaggaatcatggcaaaccgttctgtagaaatg
gttgtgggaatcatggccattttgaaagcaggtggagcctatgtgcctatcgatcccgaa
tatccagaagatcgcgtggcctacatgctggaggattgcgatgcccgtctggtgcttacc
caaaaacatcttggagctaagctggcttctagtgtgagggtggaatgcttgtatctggag
gaagagaagaattattctcccaaccgttcgaatctcgagccgattcaaaccgcttctgat
ttggcttatatcatctatacttcggggacgacaggcaagccaaaaggagtaatgatcgag
catcggggcattgtcaacagcgtgttgtggaaaaaagaggagtatcagtttagcgtccag
gatagaaatctggtgcccctgtcctttgcgttcgatggctttgttctttccttctttaca
ccgatcctttccggttcaaccgccgtcttggcgaaggatgaagaagccaaagaccctgta
tctctcagaagactcattgcagctgcgagatgcacccaaatgacatgcgtgccaagttta
ttccaagctatattggaatgcggttctgctgcggatatcagctccctacaaatcgtcaca
ctaggaggcgaaaaagtatctgctcagctcgttgagatgagcaaccagcagaatccgcaa
ctggtcatcgccaatgaatacggtccgacagaaagcagtgtcgtcgccacgcggcagcga
atttcgcaactggattctacgataacgatcggacgtccgattgccaacaccagcatctat
atcgtggacaaattccatcagctacagccaatcggcgtcgtcggggaaatttgcatcggt
ggccacggtttggcacgtggatattggaacaagccggaactcacagcagagaagtttgtt
tctcatccgtatttggaaggcgagcgcatgtacaagacgggcgatctaggaaagtggctc
cctgacggaacgattgaatttattggtcgcttggatgaacaggtaaaaataaggggatat
cggattgagattggcgagattgagtcggttatgctctcctttgaaaagctgacttcggct
gtcgtgattgtccatgaagaccaacagggccaatcgtcgcttgctgcttatttcacggcg
gaagaaaagcttgaagtctcgaatctgtggacgtatctgtcacaaagcttgccgtcttac
atgattcctgcgtacttgatccagctcaatcatctcccgcttaccccaaatggaaagatt
gacaggaaagccttgccgaaaccagaaggccgacctgtaatgggagcagaatatgtggcg
ccagcaagtcctgtggaaagcaggctggtggagatttgggaacaggtgcttggactaagc
gaaattggtgtcctcgacaacttcttccagttaggcgggcattcattgaaagccatgtcg
ctcgccgcacagatccatcgagagtatcaagtcgagctaccactcagagtgctctttgcg
actcctaccatccaagcattggcacagcatatcgagacaagtggaaaagacacgcatgta
ccgattcagcctgtaccgcagcaagagtattatcccgtttcttctgcacaaaagaggatg
tttgttctgcgccagtttgaaggcacaggcacagtctataacatgccaagcgtgatgttt
attgaaggcgatctggatcttgcacgctttgaaaccgcgatacaagggctggtcaagaga
cacgaatcgttgcggacatccttccacacagtgaatggcgagcctgttcagcgtgtacat
gaggcagtggaactggatgttcgctatgagaatttgaccgaagaccaagtagagcaaact
atcgaatcatttgtgcaagcatttgatctggagaaggctccgttgttgagagtcggactc
ttcagattgggagagaatcgacatcttttcctgatggatatgcatcacatcatttcggat
ggcgtctctgtcggaatcatcatggaagaattctcgaaactgtatcgaaacgaatatttg
ccagagcttactgttcaatacaaggattttgctgtctggcagactgatctgttccaaaca
gacatctatacaaagaacgagaactactggttgaagtccttcgcgggtgacattccagta
ctgaatctgcccgccgattattctcgcccgttggttcaaagctttgagggagattgcatt
acgttccagacagacaaaacgttgatggacgatttatacaagctcgcccatgagaaccaa
accacgctgtttatggtcttattagcggcttacaatgtgctcctttccaaatacagcggc
caagaagacatcgtggtgggaacgccgattgctggcagatcgcatgcggatgtagaaaaa
gtcttggggatgtttgtcaatacattggctttgcgaaactatcctgaaggaacgaaatca
ttccatgcatttttggaagatgtcaaacagaatacgctgcaagcatacgcccatcaggat
tatccgtttgaagcgttggtcgaaaaactggaaatccagcgggatcttagcagaaaccca
ctgtttgacaccatgtttattttgcaaaacctggacaaaaaagcttatgagctggatggg
ctgaaatttgaagcctactccggagatgggcagcaaggcaacgccaaattcgatctcaca
ctggaagcgcatgaagatgagacagggattcattttggtctcgtatactccacgaaatta
ttccaaagagacacgatggaaagaatggcaggtcatttccttcaagtgctgcgaggagtc
attgcagaccaaacagcggcgttgcatgaaatcaacttgctcggtgaggaagaaaaacac
cttgtaactgttgcattcaacaacacgtttgccgcgtatccacgggaaagcacgattcag
gagctgttcgaggagcaagtagaaagaacacccgagcatactgcagttgtgatgaacgaa
cagatgctgacgtatcgggagctgaaccaaaaagcgaatcaaatcgcaagtgctcttcgc
cgattggaagtaggaagagacagcgttgtaggtttgttggcagatcgttctctcgagatg
atcacaggcattatggggatcatcaaagcgggaggcgcctacctggggattgatccagag
catccagctgagcgcatttcttacatgctcgaagatggtggcgtgaaggttgtcctggtt
caaagacatctgttgcatctcgtcgaagaaggtctcattccaatcgttttggaagacgag
agtctggagcaagaagatggcagcaacctgaccaatctcaatggcgccaaagacttggcc
tatgtgatgtacacgtcgggttcaacgggcaaaccaaaaggagtcatggtcgagcatcgc
aatgtcacccgattggtaattcatacgaattacgttcaggtacgcgaagaagatcgcatg
attcaaacgggtgccattggctttgatgccatgacgttcgagattttcggagctttgttg
catggtgctagcttgttcctcgtgagcaaggatgtccttttggatgcggagaagctgggc
agcttcctgcgagagaaccggattacaacgatgtggttaacttcaccactgtttaatcag
ctttcgcaagacaacccggcgatgtttgaaggtttgcgtgcgttaattgtcggtggcgaa
gcactgtctccgagacacatcaacaaagttaacagcgcccatcccgctttggaaatttgg
aacggatacggcccgacagagaacacgaccttctctacatgctatttgattgagaaggaa
ttcgaagacaatataccgattgggaagccgatcacgaactccactgcttatatcgtggat
cgctacaatcagccgcagccaattggggtgccgggtgaattgtgcgtaggtggagacggg
gtagccagaggatatttgaacaagccagaattgactgccgagatgtttgttccgaatccg
tttgtttctggcgaaaacatgtaccgcacaggggatttggcgagatggaaggcagatgga
acaattgagtatttgggacgtatcgaccaacaggtaaaggtcagaggatatcggatcgag
cttggggaaatcgagagcgttctgaccaaactggaaaaggtaaaagaagctgtcgttacg
gtgatggatgatacgaacggccaaaaagctctctgcgcttattttgttccagaagaggaa
ttcgacgtagcagagctgagagaggctatttccaaagaattacctagctacatggttcca
tccttctatgttcaaatggatagactgcctttgactgcaaacgggaaggtcaatcgtaga
gcattgcctgaaccatctggagatcgggtacaaggctccacatatgtcgccccacgaaac
gcaactgagcagaagctggctgaaatttggcaagaggttctgggtatccatccgataggc
attcacgacaacttctttgaactgggtggtcattccctgaaggctatgaatgtaatcacg
caggtgcataaagcatttcaggtagagcttccgttaaaagcactgtttgaatctccaacg
atccttgagctggctacctatatcactgcgagtgaaattgaacagttcgagaccattcaa
ccagtagagcaagcagacttttacccagtctcgttcgctcaaaaaagaatgtacatcctg
catgagtttgaaggaagcgggatcagctacaacgtgccaaatgtgctgatcatagatggc
aaactggattacgaacgctttgaacatgcgatccgaacactggtaaaacgacatgaatcc
ttgcgaacatccttccattcgaaaaacggggaaccagttcaacgaatccatgaggatgtc
acgctgctcatcggtatttccgaggcgacagaagaccaagtagaacaacgcattcaggag
ttggttcagtcgtttgatctcgaggtggctccgctgttccgggttcacttgattaaactg
ggagcagaacgacacttgttcttcatggatatgcaccacattatctccgatggtgtatcg
cttgcagtcatcgccaaggagtttgcgagcttgtacgaagaaaagcagctccctgacatg
cgcatccagtacaaagattttgctgcttggcagacgaagctgtcccagtctgagcgtttc
caaaaacaggaggattattggacaaatgtctttgcaggggagattccgctactcaacctg
ccaaatgatttcccaagacctactgttcaaagcttcgaaggcgacacggtagcgatcggt
acaggtaatcacttgcttgcggagttgcgacaactcgctgcaaatacgggctccacactg
ttcatggtgcttttggcagcctacaatgtgttgctgtccaaatacgctggacaggaagaa
atcgttgtcggtacaccgattgcaggtcgatcccacgcagatgtggaacgaatcgtcggc
atgttcgtcaacacgcttgccttgaaaaatgtggcaggaggcaacctgaccttccgcgag
tttttgggtgacgtgaaacaaaatgcgctgcatgcgtttgaacatcaggattatccgttt
gaacatctcgtagataagttgcaagtacggcgcgatttaagccgaaacccactgttcgat
acgatgttcagtctggggcttgcggactcctcagcattagaaattgcaggactcaatatg
tccgcttatccggtagatggcaagatcgcgaaattcgatatcgctctggatgcgatggaa
caacaagatgagcttctcgtgcaattcaactattgcacgaagttgtttgcaaaagaatcg
atcgaccgcatggcaactcattacgtcaatcttttacagacgatcattgccaatccagat
tgcaagctggcagagatcaatgttttgtcaaaagatgagatagagcaaatgctgcatgat
ttcaatgcaacaaaagctgcttatccaacgaataaaacgttccaggagctattcgaagag
caggttgaaaaaacaccgaaccaagtagctgtcatcttcgaggatgaacagctaacgtat
cgggaattaaatgaaaaagcgaaccaactcgcacgtgttttgcgccaaatgggagtcaag
ccggagagcactgtcggcatcatggtagaccgctccttgcacatggtggtagggacgctc
ggtattttgaaagccggcggcgcctacgtcccgattgatccagactatccgttggagcgt
caagcattcattttggaagatagcgatgcgaagctgttccttaccttgcaaaagatgaat
acacagcttgcattccctcacgaaactctctatctggatgcagaggggttgtatcaggga
gaagcgagcaatctggagcctgttgcactgccggaacacgccgcttacatcatttatact
tccggtacgactggcaagccaaaaggggtcgtgatcgagcaccggagctatgcgaatgtc
gcgtttgcatggcaggatgagtatcacttggataccttcccggttcgcttgctgcaaatg
gcgagcttcgccttcgacgtatcaactggcgactttgccagagcattgctcacaggaggg
caactggttatttgcccgaatgaggtcaaaatggaccctgcttccttgtacgaaatcatc
aagcggtatgaaattactattttcgaagcgacaccagctttgatcatgccgttgatgcat
tacatttacgaaaacaagctcgacatcagtcagatgaagctcctgattctcggagcagac
agttgtccagcagaagacttcaagacgttgctcgccagatttagccagacgatgcgcatt
gttaacagttatggcgtaacagaggcgtgcatcgattccagctattacgaagaaacagat
gtctcatccattcgctcgggaacggtaccgatcggaaaaccgctgccgaatatgcagatg
tacgtgatggatccacaattgaatcttcaacctgttggagtcgtgggtgagttgtgcatc
ggtggagaaggggtcgctcgcggttatttgaacagacctgagctgacgcaggagaagttc
gtaccgaatcctttcgcaccaggtgaactattgtatcgtacgggtgatctggcgaaatgg
cgcgcggatggcaatgtagaattccttggtcgtaacgatcatcaagtgaaaatcaggggt
gtccgtatcgagctgggcgaaatcgagacacagctacgcaagctggacggaatcttggaa
gcagtcgtggtcgcaagagaggatcacagacaagaaaagtatttatgcgcgtacatggtc
gcagaacatgaaatcgacacagctcatgtacgtaaggaattgctaaaagaattgcctcaa
gcgatgattccatcgtatttcgtaactcttgaagcgctgccgcttaccgcaaatgggaaa
atcgacagacgttccttgccggcgccagatgtatctttactcagaacgacagagtacgta
gcacctcgtacggagctggaaacgcaattggcccgcgtctgggagcaagtactgaatgtg
gagcaagtaggggttctggatgatttctttgcaattggcggtcattccctgcgtgcgatg
agtgtgatttcgagcatgcataacgaatatcaagtcgatattccgcttcgtattttgttc
gaaaaaccgacgattcagcaattggctgcacacatcgaagagacagtaagagggcatgtc
atttcgattcaaccagcacctgcgcaagagtattaccctgtttcatctgctcaaaagcgc
atgtatatcctccatcagttcgagggagtcggcatcagctacaatatgccttccactatg
ctgatcgaaggaaagttggaaccggaacgattagagacagcgttcaagcagctgattgcg
cgacatgaaagtcttcgtacgtcttttgccgttgtaaatggagaacctgttcagaaagtt
cacgaggaagtttcttttgaactttcatatacaacgatcacagaagaccaggcacatgag
gttctttcatcccttgttcagccattcgatctggggatagcgccgttgcttcgcgcccgt
ctcctgcatatcggagaagatcgtcatgtgctctttaccgacatgcatcatagcatttcc
gatggtgtatcgtccggcattctcctgtctgacttagtgaagttgtaccaaggggatgtt
ttgccagagctgcgaatccagtacaaggacttctccgtatggcaacaggagcttttccga
tccgatgccttcaacaatcaagaagagtactgggctcaagtgtttgcagacgacattcca
gtgctgaacctgcaaacggatttcacccgaccaagcattcaaaatttcgcaggggatcag
tatgccatcggaactggtcaacagctcatggaaggcttgaaccagctggctcgagaaacg
ggaacgacactgtatatggtgctcctcgcgacgtacaacgtactgctttccaagtattcc
gggcaagaggacatcatcgtcggcacaccgattacaggcagatcccatgctgatctagaa
ccaatcgtcggtatgtttgtcaacacattggcgatgagaaacaagccgcatgctgggaaa
acattcaccgagttgttgctggaagtcaagcagaatgcactggatgcttacgctcatcag
gattatccgtttgaggaactggtggaaaaactcgacattccgcgagacttaagcagaaac
ccgctcttcgatacgatgtttactgtgcaaaacaacacggatgaatctatcgacttgctc
ggcttgacacttgctcctttcatgactgatcaggctggcaaccattccaaatttgatttg
actgtgattgccacagaagagcgtgaagagattcgcataggcgtggagtacagcacaagc
ttgtttacgagagagacaattgaacggttaagcaaccacttcatggctattgcccaaatc
attgtgcaaaatccgaatatccgtttgagtgaaatcgacatgctctcggcggaggagaag
cagcaaattttcgagaagttcaatgatactgctgtcagctatgtacaagacaaaacgctg
catcaattattcgaagagcaagtcgcgaagacgccaaatcaggaagccattctctttaac
ggtcagtcactgacgtacagcgagctcaatgagcgtgccaacagactggcaagagttctg
cgaaccaagggagtcggacctgatcgtcttgtagcagtcatggcggagcgttcaccagag
atgatcattggcatcctcggtattttaaaggcaggcggtgcgtatgttccaatcgaccct
gcgtatccgcaagaacgcatccagtatctgcttgcggacagcaatgcagcactgcttctc
tgccaatctcatttgtcagaactattgtctcgcgtgtcgagcgggcttgactggcttgat
ctgaacgcagagcatgacgacgagatggatggctccaatctctcatcactcaatcaaccg
accgatctcgcctatgtgatctatacatcgggcacgaccggtaagccgaagggcgttatg
attccacatcagggaattgtcaattgcttgcagtggagaagagatgaatatggattcgga
ccgggagacaaggcattgcaggtattctcttttgctttcgatgggtttgtagccagcttg
ttcgctccgcttctcggaggtgctacttgcgtcttgcctagagaggaagaagccaaagat
ccggtagcgttgaaaaagctgattgcctcaacgggagttacacattactacggtgtaccg
agtctgttccaggcgattctggattgctcgactgctgccgacttctctccgctgcgttgc
gtaacactaggaggcgagaaactacctccgcagcttgtgcaaaaaacgaaagaaaagcat
ccagcaatcgagatcaacaatgaatacggtccgaccgaaaacagcgttgtcaccaccatt
tctcgttcgattgaagcaggccaaaacatcacgattggacgaccgctagccaatgtacag
gtttacatcgtcgatacgcaacatcacttgcaaccgatcggcgtagtgggagagctatgc
atcggaggacccggacttgcaagaggttatttgaataaaccagagctcactcaagaaaag
ttcgttccaaatccgtttgtgccaggggagctcatgtataaaacgggtgacttggtgaaa
tggcggacggatggcacgatcgattacatcggtcgggctgacgaacaggtgaaggtgaga
gggtaccgcatcgagatcggggaaatcgagagcaccatactcgcttacgatggcatcgat
caagcagtggtagttgtgcaagaagatgagttaactgccggtcagtatctttgcgcctat
ctggttacagcagcagaggtatccgtttctgagctgagaaggcatctggcgaaggaactg
cctgcttacatggttccaagctattttgtccagttggatcaactgccgctttcggccaat
ggaaaagtggatcgcaaagcgttaccgaagccacagtcatcagatgcgaccactcgtgag
ttcgtggcaccaagaaatgcgactgagcatcaattggcatccatttggcaggaagttttg
gggatcgaaccgatcggcatcacagaccatttctttgaactgggtggacattcattgaaa
gcaacgctgctggttgcaaaggtgtatgagtacatgcagattgaactgccgttgaacctc
atcttccagcatccaaccattgagaaagtagcggatttcatcacgcacaagaacttcgag
ggcaactccggaagatccattctcttaaatgaagagacggcgagaaaggtattctgcttt
acgccaattggtgcccagagtgtctattaccagaagcttgctgatgaaatcaagggcgtt
tccctgtatagctttgatttcatcgaagaagacaatcgacttgagcagtacatcgaagct
atcgtcgcgattgatccaaaaggaccctatatgctcatgggatattcatcgggaggcaat
ctggcgttcgatgttgcaaaagaactggagaaccaaggatatgtcgtgaccgacctcatc
ttgttcgattcgtactggaaagacaaggtgatggagaggactctggcggaaacagagagt
gacattacccagttatttgccgaaattggagaaaacatcgagatgttcaacatgacacaa
gaagacttcaatttgtacgctgccaatgaattcgtcaagcaaagcttcattcgaaaaacg
gtcagctacgtaatgcaccacaatcaactaatcaattcgggtgcaacaaacgcagcgatt
cacctcattcaatcggagctggaatcgggcgaggaagatctagtcgcagtcaaatggaat
gaagccgcttgggcacaggctacgaaacgactgatgacgtacgaagggtacggaatccac
tccagaatgttgggaggaaattacgtgtcgatgaatgcctccatcctccgagacatcctg
caagagctgttcattctgaaataa

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