Brachyistius frenatus (kelp perch): 138617526 Help Entry 138617526         CDS       T10614                                  Symbol ryr2b Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism bfre  Brachyistius frenatus (kelp perch) Pathway bfre04020   Calcium signaling pathway bfre04260   Cardiac muscle contraction bfre04261   Adrenergic signaling in cardiomyocytes bfre04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:bfre00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     138617526 (ryr2b)    04020 Calcium signaling pathway     138617526 (ryr2b)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     138617526 (ryr2b)    04261 Adrenergic signaling in cardiomyocytes     138617526 (ryr2b)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:bfre04040]     138617526 (ryr2b)    04990 Domain-containing proteins not elsewhere classified [BR:bfre04990]     138617526 (ryr2b) Ion channels [BR:bfre04040]  Voltage-gated cation channels   Ryanodine receptor    138617526 (ryr2b) Domain-containing proteins not elsewhere classified [BR:bfre04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    138617526 (ryr2b) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  138617526 NCBI-ProteinID:  XP_069548702 LinkDB All DBs Position Unknown AA seq 4946 aa AA seqDB search MTDGGEGDDEFQFLRTGDEVVLQSTITSREEHVKLCLAAEGFGSRLCRLESTSNCKNVPP DLSVCGFVLAKCLSVRALQETLAHSKHLAAEVRGEVILFVNLQVGAGGSHRTLLYGQAVL FQHSYSGMYLSCLSSSQSSADKLTFDVGLQEDKAGEACWWTVHPASRQRSEGEKVRVGDD LILVSVASERYLHLSFGTVSDNKSLSDSLIVNAAFQQTLWSVAPICSGGAVAQGYLKGGE TLRLLHSHSDACLTIPSTEQGEELQRIMHYEIGSVSSHARSLWRLEILRVVWSGRHTCWG QPFRLCHVTTGRYLGLTEEKGLHLVDRDKADINTTSFCFRSSKDKLDAGTKTNVDGMGIP EIKYGDSICNVQHVDSGLWLTYQAADAKSRMGGTRRKAILHSEGHMDDGLTLSRSQMEES HTAKLIRSATLLFSRFTRKLDGFSREGNLPSVNLPMEMVTRSLQDLINYFQPPLEGLGHE EKQNIMTALKNRQNMFQEEGVIDLVLDCIDRLYQYSSTSEHAEAAQSDTGEEWETILNRF YELLAALIRGNRVNCAHFSGSLDWLISRLDRLEASSGVLEVLHCVLVESPEALNVIKDGH IQSIISFLDKHGCNHKVLEVLCSVCVCHGVAVRSNQNLICDTLLPDRDLLLQTRLVNQVT SMRPNIFLALGEDSAQQRRWYYELVVDHVDPFLTAEPTHLRVGWACTKGYQPRPTGGEGW GGNGVGDDLSSYGFDGLHLWSGSVGRKVSSPFPHLLKDDDVVSCCLDLTAPCISFRVNGL PVQGMSENFSASGLLHPVVSFSAGVKLRFLFGGRHGEFRFLPPPGFASCSEALLPKVKLK VEPCQKYIMDCGEGKQELVGPLVPVAPVTFIPTPIDIRKVVLPPQLEDIREKMAENIHEL WVKEKIDLGWTHGPVRDEGKRQDPCLVEFSKLPEHERNQNLQMAQDTLRTLLALGFHIGL TDDHAEERVKHMKLPSKNEQLSGYRPAPVDLRQVFLSSAHEEVVNLLAENEHNVWARERI KQGWTHGAQQDVKAKRSPYHVPYSLLDERTRKMGRESVREAVCTLLAYGYSLEPVNQEHT TSSKPCLFSAEKFRVFRPDKSYAVTRGKWYFEFEILTAGNMRVGWARPGCTPDKELGSDD QAYVFDGFEAQWYHQGGEPLGRLWLRGDVVGCLVDMAERTMMVTLNGELLFNDRGSELAA KDFDIGDGLLPVVSVGVNQAGRLNLGRHVRSLQYFTVCGLQEGFRPFAVNMARDPALWMS WNLPQFTSILPDHHNLQVTRVSGTKDSLSSLRVCQRMFAHHNGGSEIGFYRLSMSVECAA VLRSPAGVGLSVASSSLSPSSARKEQEEVDSDFEMLMKSAHRFAGSRDELNHKDHSQDKT SRLKQRFMLKRMKPDLVSSNSSARLLEDVVVDRDNYDHLIQSSRYYYSVRVLPGQQPFNV WVGWVTSDFHQYDVTFDVDNTPTVTVTLGDDSGKVQESVKRCNCYMVCAGEATGLSQSRR SAGLEIGCLIDSTTGLLTFTSNGVEMTTFYQVEASTKLFPAVFVEPTTSNMFQFELGRIK NVMPLSSGLLRNQRRNVTPQCPPRLLVQQLSPVSWTRVPDRALTVLVDRPDERHGWRVQC CEPLQVLTLQIPDENRSVDILELSELDDLLTFHHHTLLLYCSLCTLGNTRVCHALCSHVD QSQVLHAIKNPHLPGPLRSAFYQLLIEVYLSSHTTACLMMNHEYIVPMTDQTRGITLYPN PVNGVNGNPEGLPSARRSTSLKPQIHFSPPCFVRSDVMKGDGEVEISYVNSPEIPLDILK NLTVEMLTAGVWAVGRAVRDPAGGSIELLLVPLLRLFYSLLVMGVFGDEDLEKVLRLLEP YVFSINAETLMEGEEEEEEETSDDEEESKGGNKKDDDTIKQGLLQMKLPEAVKLELCHLL SYLCDCQVRHRVEAVIAFSDNFVGELQENQRFRYNQVMEALNMSAALTARKTKEFRLPPQ EQINMLLSFREDEQHENCPCPVEIQHLLQDFHHLLNTHCGIEVDSDSEDEEDAEMSVKDR LVSLVARVIGLNKTPKEMEAWRSQSLKKLISETMVRWAQESEMEDAELVRAVFSLLHRQY QGLGGQMEEPLRKAYTISQSSVKDTVALLSSLGQIRSLLSVRMGKEEERLMIRRLGDIMN NKVFYQHPNLMRALGIHETVMEVMVNVLGEGESKEISFPKMVASCCRFLCYFCRISRHNQ GALFDHLSYLLENSSVGLASPSMRGATPLDVAAASVMDNNELALALREPDLEKVVQYLAG CGLQSCPMLVAKGYSDIGWNPVEGERYLDFLRFAVFCNGESVEENAYVVLRLLIRRPECF GPALQGDGGNGLLAALEEAIRMSEDPSMDGPCATNQSNRALDVVQDNDDDLIHMGHAIMT FYSALIDLLGRCAPEMHLIQGGKGEAIRIRAILRSLIPVQDLEGVISISFQIPSVSKDGL VVEPDLSTVFCPDHKAAMILFLDRVYGIENQRFLLHLLEVGFLPDLQAAISLDTADLGSI DMALALNRYLCTAVLPLLTKYSSLFYDLEDHILLVDSLIQAVYCLSRALSLTKAQRDTTE DCLLALCSKLQPSMMQPLLRRLVFDVPHLTEHSIMPLKLLTSHYEQMWKYYSQAVEQINH GLASEEELHLSRKLFWGLFKALAKKPYVPQLFKLSVQCLAAVSKALPPSHMDPSLSQMER KASTDTDGHFDPQPVHTSNVSVPERLEFVVNKYAEHTHEKWSLDKFANGWVHGEQLCENT KVHPLLKPYRAVAEKEKEAYRWAIKETIKSMLAFGWTIERTKEGDAFGKNACTRRVSQSG QLSFEGASTFSPKPTDMSSITLSWEQCAMAEHMAENYHNAWAKTKKLELESKGGGSHSML VPYDTLTAKEKTKFRERARDVLKFLQLNGYTVLRDRKTVEMDFPAMANCFGYTLLLWLLS HSEEAQEKILELARGQMSKGENAPHQQPIIFFHKVILPLLEQYVKSHLLYFLSTSLCSSV NNSHASKKEKEMVACLFCKLAALVRHRISLFGNEDSSFTSCLQVLAQALDARTLMKSAPE SIQTSLRSFFEAAAADLETTVEHLNETLVAMPQSRGQLARGVAKVLNYTTSILLPTLTSL FHHLGNQNYGVDLLVGGIQVSCYRILNSLYSLGTSSSIVMEGQRSAAGACLAALTGAFPV CFLEPNLNQNNPYSIYSTAETKDRGMPDQVEDMCPLLPSLGQALREVEGLAGAGAGARQA HYVHVTEVTLPMLCSYISHWWHWGPEGQPDSPICTSVLPKHASDLLGHILRIIHNHVGAN QGDWMKQLAVFSQPIICKARTGLLKSHFLPLMEKLRKRAECVLLEEERMKADGCCTSEAE LQIQEKFTMLVRDLYAFYPLLIPFVDSNRAIWLKDPNPEAQQLFSMVAEVFIFWAKSHNF KWEEQNFVVQNEINNLAFLVNNDKMSKVSLIYHEKKRIKRKGDRYSTHTSLIVASVKRLI PVGLRDCFPSESLLMLAKNGFSQKKTEDEIREHIFNFVQQHVHGDIADAQRTADRILEIA RVLYYLDQVDHPQKNKKPAWHKVLSKQRKRAVVACLRMTPLYNLPRHRAVNLFLQGYNKS WISAEDNSFEEMLVEDLAKSGVMEPCGGDKGEEKNVEEGAKPIDPLLQLITLFSRSALTE SSKHGNDRLCESYAAIMAKSCCTDDDDDDDDEEQEVESFEEKEMEKQKLLYQQARLHRRG ASEMVLQTISASKGVMGSLIAPTLKLGIAVLNGGNATVQQKMLDYLREKRDVGFFQSMAG LMRSCSVLDLNAFERQNKAEGLGMATDDSSGEKVMPDKDQTCDLFRFLQLLCEGHNSEFQ NYLRTQTGNNTTVNVIISTVDYLLRVQESISDFYWYYSGKDVIDAQGQHNFSKAIEVAKQ VFNTLTEYIQGPCSGNQQSLAHSRLWDAVVGFLHVFAHLQMKLSQDSRQIELLKELMDLQ KDMVVFLLSMLEGNVVNGTIGKQMVDMLVESSGNVEMILKFFDMFLKLKDLTSSDAFREY DPDCKGSISKKDFQKAMENCKHFCQAETDFLLSCTESDDSEIVDYEAFVDRFHEPAKEIG FSIAVLLTNLSEHMPNDPRLKTFLELAECVLTYFQPYLGRIEILGSGKRFERVYFQISEY SRTQWEKPQVKESKRQFIFDVINEGGEKEKMEMFVNFCEDTIFEMQLAAQISGSNTGERC AGRQVEERSKEEDPDNKRMFFMYQWLLLLTSLLSVKNVKTLMKMTVKDIVMAAVLFLRLI CMAQMRFICVVIRSIIFVLYVSFVSGGLIERAKRLRMSDLLGGILEPTLDEVMEVSCGVD RLRKYSASFSSQRELRKIGQMAAVTSPREVDALSDIFGLKLRKEGGQYRIITQDLTASLT DLFNTTSRTSDISETHRTTQFKDPTATEEKMEDEKMPKLENTEGKISEEKTGNEKAERRW RAKRCSRETQSPNSALWEMISTHNKSLLSYFARNFYNMRLLALFVAFAINFILLFYKVRQ RSTSSSPASQEEAGVTTSVYSEELDSGAEDDSKGRVYFVLEESSGYMEPSLRFLAVAHTI ISFCCIIGYYCLKVPLVIFKREKEVARRLEFDGLYVTEQPPEEDIKGQWDRLVINTPSFP SNYWDKFVKRKVMDKYGDFYGCDKISKLLGLDRAALDFSSERKEKRLRRDAAWSALFNSI DMKYQVWKLGVVFTDNSFLYLAWYMTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVT HNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSDDKDTRDMKCNDMLTCYMFHMYVGV RAGGGIGDEIEDPAGDEFEVERIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVK EDMETKCFICGIGSEYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVW KMYQERCWEFFPVGDCFRKHYEDQLG NT seq 14841 nt NT seq  +upstreamnt  +downstreamnt atgactgacggtggagagggcgacgatgaattccagtttctacgaaccggagatgaggtg gttttgcagagtaccatcacctcccgggaggaacatgtgaagctctgtcttgctgccgaa ggatttggcagcagactttgcaggcttgagtccacctctaactgcaagaatgttccacca gacttgtctgtatgtggctttgtcctggccaagtgtctctctgtccgagccctgcaggag acgctggcccacagcaagcacctggctgcagaggtgagaggtgaagtcatattgtttgta aatttacaggtgggagctggaggaagccatcgcacccttctgtatggccaagcagtgctg ttccaacactcatacagtggcatgtatctcagctgtttgtcttcatcgcagtcttcagct gataagttgacctttgatgtcggtctgcaagaggataaagcaggggaggcgtgttggtgg accgtccacccagcatccagacagaggtcagagggtgagaaggtgcgtgttggagatgac ctcattctggtcagtgtggcttcagaaagatatctgcacctgtcctttggcactgtatct gacaacaaaagcttgagtgacagtctgattgttaatgcagcctttcagcagactctctgg agtgttgctcccatctgctctggtggtgcagtcgctcaaggatacctgaagggaggtgaa acattgcggctcctccacagccatagtgacgcatgtctgactattccctcgacagagcaa ggagaggagcttcaaaggataatgcattatgagattggatcagtgtccagccatgcccgc tctctctggaggctagagattctgcgtgttgtctggagtggtagacatacgtgttggggc cagccgtttagactgtgccatgtgactactgggaggtacctgggcctcacggaggagaaa ggcctgcatctggttgatcgggacaaggcagacatcaatacaacctccttctgctttcgc tcatcaaaggacaagctggacgctggcacaaagacaaatgtcgatggcatgggaatccca gagatcaagtatggagactccatttgtaatgttcaacatgtagactctgggctctggttg acctaccaggctgctgatgccaagtctcgcatgggaggaactcggcgaaaggccattttg cacagtgagggtcatatggacgacgggctgacactgtctcgctctcagatggaagaatct cacactgccaaattaatccggagcgctactctcctcttctctcgctttacaaggaaacta gacggttttagtcgagaaggaaaccttccctctgttaatctaccaatggagatggtgaca cgtagtctgcaggatctaataaactatttccagcctcccctggagggtctaggccatgaa gaaaaacagaacatcatgacggcgctaaagaaccgccagaacatgtttcaagaagagggt gtgatagatttggtcctagattgtattgaccgtctataccaatatagtagcacttctgag catgccgaggcggctcagagtgacacaggagaagagtgggagaccatcctcaaccgcttc tatgagctactggctgctctgatccggggaaaccgtgtgaattgtgcacatttctcaggt tctctagactggctgatcagcaggttggaccggctggaggcttcttctggagtcttggag gttctacactgtgtccttgtggaaagtcctgaagcactcaatgtcatcaaagatggacac attcagtccatcatctcgtttctagacaagcatggctgcaaccacaaggtgctggaggtg ctgtgctctgtgtgcgtgtgccatggtgtggcagtgcggtccaaccagaacctcatctgt gacaccctgctgccagacagagatctgctcctccaaacacgtctggttaatcaggtcacc agcatgagaccaaacatcttcctggctttgggggaagattccgcgcagcaacggaggtgg tactacgagttggttgtggatcacgtcgaccccttcctcacggctgagcctacacacctg cgtgttggctgggcttgcaccaaaggataccagcccaggcccacaggaggagaaggctgg gggggcaacggagtgggagacgacctctcctcctacggcttcgatgggcttcacctctgg tccggctctgtgggccgcaaagtcagctcccccttccctcacctgctgaaagatgacgat gtggtcagttgctgtctggacctcaccgctccctgcatctccttccgggttaacggcctg cctgtgcagggcatgtcagaaaacttcagcgccagcggacttcttcatcctgtggtcagc ttctctgcgggagtcaagcttcgttttctgtttgggggaaggcacggcgagtttcgcttc ctgcccccgccaggttttgcttcatgctctgaagctctgctcccgaaagtcaaactgaag gtagagccttgtcagaaatatatcatggattgcggagaaggaaaacaagagcttgtcggc cccttggtacccgtcgctccagttaccttcattcccacaccaatagatatccgcaaggtg gttttgcctccacaacttgaggacatcagagaaaaaatggcagagaatattcatgagctc tgggtaaaagagaagattgatcttggatggacacatggaccagtgagagatgaaggtaag aggcaggatccgtgtctggtggagttctctaaactgccagagcacgagagaaaccagaac cttcagatggctcaggacaccctcaggactctccttgctctcggtttccatattggtttg acggatgaccatgctgaggaacgagtcaaacacatgaaacttccctccaagaatgagcag ctcagtggctacagacctgctccagtggacttgagacaggtttttctgagctcagctcac gaggaggtggtgaacttgctggcagagaatgaacacaatgtatgggccagagagcgtatc aaacagggatggacccatggagcccaacaggatgtaaaagcaaagcggagcccgtaccat gtgccctacagccttcttgatgaaaggaccaggaaaatgggccgggagagcgtcagagag gcggtctgcaccctgctggcttacggttacagcctggagcccgtgaaccaggaacacacc acatcatcgaagccatgtctcttctctgctgagaagttcagagtgttcagaccagataaa tcttacgcagtgacccgggggaagtggtattttgaatttgaaattctaacagcggggaat atgagagtgggctgggcccgaccaggctgtacgccagataaagagctcggctcagatgac caggcatacgtctttgatggatttgaggctcagtggtaccatcagggcggcgagcccctg ggacgtctgtggctcagaggcgatgtggtgggttgcctggttgacatggctgaacgcacc atgatggtcacgctcaatggagagctgctgtttaatgacagaggatcagagctggctgcc aaggactttgatatcggagatggcctgttgcctgtggtcagtgtcggggtgaaccaggca gggaggctgaacctgggccgccatgtgaggtctctgcagtactttactgtgtgtggcctg caggaaggtttcagaccttttgccgtcaacatggccagagacccggccctgtggatgagt tggaacctgcctcagtttacctccatactgcctgatcatcacaatctacaggtcacaaga gtcagtggcacaaaggattccttgtccagcctgagggtctgtcagcggatgttcgcacac cacaatggagggagcgaaataggcttttaccgactcagcatgtctgtggaatgtgccgcc gttctcagaagccccgcgggggtcgggctttcagtggcttccagctctctcagtccaagt tcagcaaggaaagagcaggaggaggtggactctgactttgaaatgctgatgaagtcagcc cacagatttgctggctcgagagatgagctcaaccacaaggatcatagccaggacaaaact tcaagactgaaacaacggttcatgctgaagaggatgaaaccagacttagtcagcagcaac tcatctgcacggcttctcgaagatgttgtcgttgacagagataactatgatcacctcatc caaagctccagatattactactcagtgcgggttctgccagggcagcagccattcaatgta tgggtaggctgggtgacctcagactttcatcagtatgacgtgacatttgatgtcgacaac acccccactgtgactgtcaccctcggagatgacagtgggaaagtccaggaaagtgtgaag cggtgtaactgttacatggtgtgtgctggagaggcgacaggtctgtctcagagtcggaga agtgccgggttggaaattggctgtttaattgattcaaccaccgggctgctcacctttacc tccaatggagtggagatgactactttctaccaagtggaggcaagcacaaagctgtttccg gctgtttttgtcgaacccaccaccagcaacatgtttcagtttgaactgggacgtatcaag aatgtgatgccgctgtcgtcgggtttgcttcgcaaccaaagaaggaatgtcactcctcag tgtcctccgaggcttctggtccagcagctcagccctgtttcgtggaccagagtgccagac cgtgcgttaacagtgttggtagatcggccagatgagcgccacggctggagagtccaatgc tgtgaacccctgcaagtcttgaccttgcagatccccgatgaaaacaggtctgttgacatt ttggagctgtcggaacttgatgacctcttgacctttcaccaccataccctcctcctctac tgctctttatgcacccttggcaacaccagagtttgccatgccctctgcagtcatgtggac cagtcgcaggtccttcatgctattaagaatccccacctccccggcccacttcgctctgcc ttctatcagctgcttatcgaggtttacctcagcagccacaccacagcatgtctcatgatg aaccatgaatacattgttccaatgacagaccaaaccagaggaatcaccctttatcccaat cctgtaaatggtgttaatggaaatccagagggacttcccagtgctcgtcgtagcacatca cttaaaccacagatacatttctcacctccatgttttgtcaggagtgatgtgatgaaagga gatggtgaagttgaaatttcctacgtaaacagcccagagatccctctggacatactgaaa aatctgactgtggagatgctgactgctggagtttgggccgtgggtcgggctgtgagggat cctgcaggaggcagtattgagcttctgcttgttcctctgttaagactgttctacagcctt ttggttatgggggtatttggggatgaggacttggagaaggttctcagactgttggagcca tatgtgttctccataaatgctgaaaccctcatggagggggaggaggaagaagaggaagaa actagtgatgatgaagaagaatccaaagggggcaacaaaaaagatgatgacaccatcaaa caaggacttcttcaaatgaagcttccagaagctgtcaaacttgagctgtgccatctactg tcctacctttgtgactgtcaagtgcgtcacagggttgaagctgtgattgccttctctgac aactttgtgggtgagctgcaggagaaccaacgctttcgctacaaccaggtcatggaggcg ctcaacatgtcggccgcactcactgctcggaagaccaaggagttccgcttgcctccacag gagcagatcaatatgctgctgagcttcagagaggatgagcagcatgagaactgtccatgt ccagtagaaatccaacacctcctgcaagacttccatcatctcctcaacacgcactgcggc attgaagtggacagtgactcagaagatgaagaggacgccgagatgtctgttaaagatcgg cttgtcagtcttgtggcgagagtcatcggacttaataagacacccaaagaaatggaagcg tggagatcacagtccctcaaaaagctgatctctgaaacgatggtgcgctgggctcaggag agtgagatggaggatgctgaactcgttcgggctgtcttctcactgctgcaccggcagtat caaggtctggggggccaaatggaagaacccctccgcaaggcctatacaatcagccagtct tcagtgaaggacaccgtggcactcttgtcctccctgggccaaatccgctctctcctcagt gtccgcatggggaaagaagaagagaggctgatgatcagaagacttggagacatcatgaat aataaagttttctaccaacaccccaacctgatgagggcactggggatacatgagacggtg atggaggtgatggtcaatgttcttggagaaggggaatcaaaggagatttcctttcccaag atggtggccagctgctgtcgattcctgtgttacttttgccgcatcagtcgtcacaatcag ggagccctgtttgaccacctcagctacttattggagaacagcagcgttggtctcgcttca ccatccatgcgtggtgccactcctctagatgtggcagcagcctctgtcatggataacaat gaactggccttggcactgagggaacctgacctagagaaggtggttcagtacctcgctggc tgtggtctccagagctgtccgatgcttgtggcaaaaggctattctgacattggatggaac cctgtggagggcgagcgttacctggattttctacgttttgctgtcttctgcaacggtgag agtgtcgaggagaacgcgtatgtggtgttgaggttgttgatccgtcggcctgaatgtttt ggccccgcactgcaaggcgacgggggaaacggtctcctagcagccttggaggaagccatc aggatgtctgaagacccttctatggatggaccgtgcgccactaatcagtccaacagagcg ctagatgttgtccaggacaatgatgatgacctcattcacatggggcacgccatcatgacc ttctactccgctcttattgacttgctggggcgctgtgctccagagatgcatttgattcaa ggaggcaaaggagaagccatccgcatcagagccattctgagatcactcatccctgttcag gatcttgagggagtcatcagcatctcctttcaaatcccttcagtgtctaaagatggtctg gtggttgagcctgatctatctacagtgttctgcccggaccacaaggcagctatgattctg ttcctggatcgggtttacggcattgagaaccagaggtttctcctccaccttctagaagtt ggctttctgcctgaccttcaggcagccatttctcttgacactgcggacttgggatccatt gatatggccctggccctcaacagatatttgtgcacagctgtacttcccctgctcaccaaa tattcatctctcttctacgatttagaggatcatatcttgctggttgattctcttatccag gcagtctattgcctctcaagggctcttagcctgaccaaggctcagagagacactactgaa gactgtttgttggctttgtgcagtaaactccaaccatccatgatgcagccgcttcttcga cgactcgtcttcgatgttccccatctcacagagcacagcataatgccactcaagctcttg accagccactacgagcagatgtggaagtactactcccaagctgtggagcagattaaccac ggtttggcctctgaagaggaactccatctttccagaaagctgttctggggcctgtttaaa gccttggcaaagaagccgtatgtgcctcagttatttaagctgagtgtgcagtgcctggct gcagtgtccaaggctctgcctccttcccatatggacccaagtttatcccaaatggagaga aaagcttccacggacacagatggacactttgacccccaacctgtacatacttccaatgtg tcagtgccagagagactggagtttgttgtgaacaagtatgcagagcatactcatgagaag tggtcactggacaagtttgccaatggctgggttcacggggagcagctatgtgagaacacc aaggttcaccctctcctcaagccatacagggctgtggctgagaaggagaaggaggcgtac cgctgggccatcaaggagacaataaagagtatgctggcctttggttggaccatagagagg accaaagaaggggatgcatttggcaagaacgcctgtacacgtagggtctcacagtctgga cagctttcttttgaaggagcatcaaccttcagccccaaacctacagacatgagcagcatc accttatcatgggaacagtgtgctatggctgaacatatggctgaaaactaccacaatgcc tgggctaagaccaagaaactagaacttgagagtaaaggtgggggcagccattcgatgctt gtaccctatgataccctgactgccaaggagaagaccaaattcagggaaagagcccgggat gtcctcaagttccttcaactcaatggctacactgtgttgagggatcggaagacagtggaa atggactttccagccatggctaactgctttggctacactctccttctgtggctgctgtct cactctgaggaggcccaagagaagattttggagcttgccagaggacagatgtcaaaagga gaaaacgctccacaccagcagccaataatttttttccacaaggtcatccttcctcttttg gaacaatatgtgaaaagccaccttctgtatttcctgtccacatctctctgctcaagtgtt aataacagccatgcctcaaaaaaggaaaaggagatggttgcatgcctcttttgtaagctg gcagctctcgtaagacacaggatctctctctttggaaatgaagactcgtcatttacaagc tgcctccaggttctggctcaggctcttgatgccaggacattgatgaagtcagcaccagaa tccatccagacaagtctgcgttcattttttgaggcagctgctgctgatttagagacgact gtggaacaccttaatgagactttggtcgccatgcctcagagtagaggtcagctggccaga ggagtagcaaaggttctcaactacacaacctccattcttctccccaccctcacttccctc ttccatcatctgggcaaccaaaactacggcgtggacctcctggttggtggtatccaggtg tcctgttacaggatcttgaacagcctctactctcttggaaccagtagcagcatcgtcatg gaggggcagaggtcagcagcaggtgcctgtcttgcagctctgactggggcttttcctgta tgcttcctggagccaaatctaaaccaaaacaacccttactccatctacagtaccgctgag acaaaagaccgggggatgccagatcaggtggaggacatgtgtcccctcctgccttctctg ggacaggcactgcgtgaagtggaggggttggcaggtgctggtgctggagcacgccaggcc cattacgttcatgtcaccgaggtcaccttgcccatgttgtgcagctacatttctcactgg tggcactggggtcccgagggccagccagatagcccaatctgcacctctgtccttcctaag catgcgagtgaccttcttggccacatcctccgcatcatccacaaccacgtgggcgctaac cagggtgactggatgaaacagctggcagttttttctcagccaatcatatgcaaagctcgg actggacttctaaagagccacttcctgccactgatggagaagttgagaaagagggccgaa tgtgtgctgctggaggaggagcggatgaaagctgacgggtgttgtacctctgaagcagag ttgcagatacaggagaagttcaccatgctggtccgagacctctatgccttttatcccctc ctcatcccatttgtggattctaatcgagccatatggctgaaagacccgaaccctgaggct caacagctgttcagcatggtggcagaggtctttatattctgggccaaatctcataacttc aaatgggaggaacagaatttcgtggtccaaaatgaaatcaacaacttggcttttttggtc aataatgacaaaatgtccaaggtcagccttatttaccatgagaagaagaggataaagagg aagggggatcggtattccacacacacctctctcattgtggcgtccgtgaagagactgatc cctgtgggactacgggattgttttccaagcgagagtcttctcatgctggctaagaacggc ttctctcagaaaaaaactgaagatgagattcgagagcatattttcaattttgtacaacaa cacgttcatggagacatcgctgatgcacaaaggactgcagacaggatcctagaaatagct agagttctttattacctggaccaggttgaccacccgcagaaaaataaaaaacctgcatgg cacaaggtcttgtcgaaacagaggaaacgtgcagtggtggcctgcctaagaatgactccc ctctacaatttacccaggcaccgtgctgttaacctgttcctccaaggctacaataaatcc tggatatcggctgaggacaacagttttgaggagatgctcgtggaggatttagctaagagc ggagtgatggaaccgtgtggaggcgacaaaggggaagaaaagaatgtggaagaaggtgcc aaaccaatcgatcccctcctacaactcattacactcttcagtcgaagcgccctgacagaa agcagtaagcatggaaatgaccgtctctgtgagtcctacgcagccatcatggccaagagt tgctgcacagatgatgatgatgatgatgatgatgaagaacaggaggtggaaagctttgaa gagaaggagatggagaaacagaagctgctgtaccagcaggcccggctgcatcgtcgtgga gcttctgagatggtgctgcaaaccatcagcgccagcaaaggtgtcatgggttccctgatt gccccgacgctcaagctaggtatcgctgttctcaacggaggaaatgccactgttcaacag aaaatgttggattacctgagagagaagcgagatgttggcttctttcagagcatggctgga ctcatgcggtcatgtagtgttctagatctgaatgcatttgaaaggcagaacaaagcagaa ggattaggcatggccacggacgacagctcaggagaaaaggtgatgcctgacaaagaccaa acctgtgacctgttccgtttccttcagctgctctgtgaaggacacaactcagagttccag aattatttgagaacacagacaggcaacaacaccacggtcaacgtcattatatccactgtg gactatttactaagagtgcaggagtcaatcagtgacttctactggtactactcggggaaa gatgtaattgatgcacaaggacaacacaacttctccaaagccatcgaagtggccaaacag gtgttcaacacactcacagagtacattcagggcccttgttctgggaaccaacagagtctt gctcacagtcgtctttgggacgctgttgtgggattccttcatgtgtttgctcacctgcag atgaagctctctcaggattcaaggcaaattgaacttctgaaagagctcatggatttacag aaggacatggtggtgtttttgctctccatgttagaaggtaatgtggtcaatggcactatt ggaaagcagatggtggatatgttggtggaatcgtcaggcaacgtggagatgattctgaag ttttttgacatgttcctcaaacttaaagacctcacctcctcagatgccttcagagagtat gaccctgattgtaagggcagcatatccaagaaggactttcagaaagccatggagaattgc aaacatttctgtcaagctgaaacagacttcctgctctcctgcacagagagcgatgatagt gaaattgtggattacgaggcctttgtggatcgcttccatgagccggcaaaagagatcggc ttcagcatcgctgttcttctcaccaatttgtccgagcacatgccgaacgatccaagactg aagaccttcctggaactggcagagtgtgtcttgacctacttccagccctacctgggacgc attgagatcctcggcagcgggaagcgctttgaacgcgtctacttccagatcagtgaatac agccgcacacagtgggagaagccacaggtcaaagagtccaagaggcagttcatttttgac gtgatcaatgagggtggagagaaggagaaaatggagatgtttgtcaatttctgtgaggac accatctttgagatgcagcttgctgcccagatatccggctctaacactggagagaggtgt gctggaagacaagtagaggaaaggagcaaagaagaagacccggacaataaaagaatgttt ttcatgtaccagtggctgcttttgctgacatctctactttctgtgaaaaacgtgaagaca ctgatgaagatgactgtgaaggacatcgtcatggcagctgttttgttcctcagattaatt tgcatggctcagatgcgtttcatttgtgttgtaattcgcagcattatatttgtgctgtac gtatcctttgttagtggtgggctcatagagcgagccaagaggttgaggatgtcggacttg ctcggtggcatccttgagccaactcttgatgaggtcatggaggtatcatgcggtgtggat cggctgaggaagtattctgccagtttctcttcccagagagaattgagaaaaattgggcag atggctgctgtgacctcccccagagaggtggatgcactgtcagacatattcggcctcaaa ctgaggaaggagggaggtcaatacagaattatcacacaagacctcactgccagtctgact gacttgttcaacacaacctccagaacaagtgatatttctgagacgcatcggacaacgcag tttaaggaccccacagccacagaggaaaaaatggaagatgagaaaatgcctaaattagag aacacagaaggtaaaatatctgaggagaaaactgggaatgagaaagcagagagaagatgg agagccaagagatgctccagggaaacgcagagcccaaactctgccctctgggaaatgata agcactcataacaagagcctgctgagctactttgcaaggaatttttataacatgcgcttg ctggctctttttgtcgccttcgcaatcaacttcatccttctcttctacaaggtgagacag agaagtacatcatcctcgcctgcatcccaagaggaggcgggggtaaccacatctgtttac agtgaggagctggactctggtgctgaagacgatagcaagggcagagtttattttgtgctg gaagagagcagcggatacatggagccctctctccgtttcctggctgtagctcacacaatc atctctttctgttgtatcataggttactactgcctcaaggtaccattagtgatcttcaaa cgtgaaaaggaagtggcgcgtaggttggagtttgacgggctgtatgtgacggagcagccg cctgaggaagacatcaaaggccaatgggacagacttgttattaacacaccatctttcccc agcaactactgggataaatttgtgaagaggaaggtgatggataagtatggtgacttctac ggctgtgacaagatcagcaaactcctcggtctggaccgagctgctttagactttagctct gaaagaaaagagaagcgactcaggagagacgctgcctggagtgctctatttaactccatt gacatgaagtaccaggtctggaagctgggagttgtgttcactgacaattccttcttgtac ttggcatggtacatgacgatgtcaattttgggtcattacaacaacttcttctttgctgcc cacctgttggacatcgctatgggcttcaagacactacgtaccatcctgtcctccgtcaca cacaatgggaaacagctggtccttactgtgggcctgttggcggttgtggtgtatctctac accgttgtagccttcaacttcttcaggaagttttacaacaagagtgatgacaaggacacc cgagacatgaagtgcaacgacatgctcacgtgttacatgttccacatgtatgtgggagtg cgtgcgggtggtggcatcggtgacgagatcgaggaccctgctggagatgagttcgaggtg gagcgcatcgtctttgacatcacgtttttcttcttcgtcatcgtcatcctcctggccatc atccagggcttgataattgatgcctttggagagcttcgagaccagcaggaacaagtgaaa gaggacatggagaccaaatgtttcatatgtggaattggaagtgaatactttgatacagtc cctcatggctttgagactcacactctacaagagcacaacttggccaactatctatttttt ctgatgtaccttattaacaaggatgaaactgaacacacggggcaggaatcctatgtgtgg aaaatgtaccaggagcgttgctgggaattctttcctgtgggagactgtttccgtaagcac tatgaggatcaactgggatga

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