Brachyistius frenatus (kelp perch): 138626858 Help Entry 138626858         CDS       T10614                                  Symbol ryr2a Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism bfre  Brachyistius frenatus (kelp perch) Pathway bfre04020   Calcium signaling pathway bfre04260   Cardiac muscle contraction bfre04261   Adrenergic signaling in cardiomyocytes bfre04371   Apelin signaling pathway Brite Ion channels [BR:bfre04040]  Voltage-gated cation channels   Ryanodine receptor    138626858 (ryr2a) Domain-containing proteins not elsewhere classified [BR:bfre04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    138626858 (ryr2a) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  138626858 NCBI-ProteinID:  XP_069564921 LinkDB All DBs Position Unknown AA seq 4960 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCSATIHKEQLKLCLAAEGFGNRLCFLESISNSKNVPP DLSICTFVLEQSLSVRALQEMLANTEEKADGTSQGGGHRTLLYGHAVLLRHSYSGMYLCC LSTSRSSTDKLAFDVGLQEDTSGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYL HLSYGNGSLHVDAAFQQTLWSVAPICSGSEVAQGFLIGGDVLRVLHGHMDECLTVPSGEH GDEQRRTVHYEGGAVSSHARSLWRLETLRVVWSGSHIRWGQPFRLRHVTTGKYLSLIEDK SLLLMDKEKADVKSTAFCFRSSKEKLDPGVKKEVDGMGAPDIKYGDSVCYIQHVDTYLWL TYQTVDAKCARMSGVQRKAIMHHEGHMDDGLTVSRSQHEESHTARVIRSTVFLFNLFIRG LDTLRKKGKGSTLDLPIDSVSLSLQDLIGYFQPPGDQLEHEDKQNRLRALKNRQNLFQEE GIISLVLECIDRLHVYSSAAHFAEAVGREAAEAWSSILNSLYQLLAALIRGNRKNCAQFS GSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIICLLDKHGRNHKVLD VLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLINHVSSMHPNIFLGVSDGSAQYRK WYYELIVDQVLPFVTAEATHLRVGWANTSGYAPYPIGGEGWGGNGVGDDLHSYSFDGLHL WSGCIARTVSSPNQHLLRAEDVVSCCLDLSVPSISFRINGQPVQGMFENFNSDGLFFPVA SFSAGVEVRFLLGGRHGEFKFLPPPGYAPCYEAVLPREKLKLEASQDQTAAKELLGPTIT LSQAAFTPTPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWTYGAVRDDNKRQHP CLVEFSKLPEQERSYNLQMSLETLKTLLALGCHVGLADEHAVEKVKSLKLSATYELSCGY KPAPLDLSHIKLTSTQESMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNRRNPRLVPYI LLDERTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAAQSDVSNMSAERFRIFRAEKTYCV SVGKWYFELEVLTAGEMRVGWARPGCLPDQELGSDDQAFVFDGFKVQRWHQGNEHFGRAW QTGDVVGCMVDLNEHTMMFTLNGEVLLDDSGSELAFKDFEAGEGFIPVCSLGVCQVGKMN FGKDVSTLKYFTICGLQEGYEPFAVNMNRDVTMWLSKRLPQFVPVPPNHQHIEVTRIDGT VESCPCLKVTQRSFGSQNSYTDITFYRLSMPIECSESRSPSNCSIFSTKKELEDFETVSD FEVLMKSSHGHNGPNAPDRDEFNNHKDYNQEKPSKLKQRFTLKRNKPDNSCPSSARLSEE VISDDKDGYEILMQAPAHYYSVRIFPGQEPSNVWVGWVTSDFHQYDPGFELHKVRTVTVT LGDEKGKVHESIKRSNCYMVWAGESSSPGQGRSNNGLEIGCVVDTTNGLLTFTANGKELS TFYQVEPSTKLFPAVFAKATSPNVFQFELGRIKNVMPLSAGLFKSEKKNPVPQCPPRLHV QFLTPVLWSRVPNHFLKVSASRVNDRHGWLVQCNEPLQFMSLHIPEENRSLDILELSEQK DLLKFHYHTLRLYSAICALGNNRVAHALCSHVDEAQLLQAIENKYMPGRLRAGYYDLLID IHLSSYATARLMMNNEYIVPMTDETKSITLFPDEKKKHGLPGIGLSTSLRPRMHFSSPSF VCGTGPSCRSNGNNGSGDCFQYSPEFPLDILKIKTIEMLTEAVREGSMHVRDPIGGSTEF LFVPLIKLFYTMLIMGVFQNGDLKNILQLIEPSVFSERRDGQEESHMELEAVETEGGGED GERKIPKEGLLQMKLPEPVKLQMCHVLQHLCDCQVRHRIEAVVAFSDDFVACLQDNQRFR YNEVMLALNMSAALTAKKTKEFRSPPQEQINMLLNFKDEKQECPCPEYIQDQLLDFHEDL MKHCGIELDEERGIDDDGDFTIRGRLMSLVEKVAYLKNKMTNLPLEKKERKPSTLQQLIS NTMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGQVRALPKTYTINSVSIEDTINLLAAL GQIRSLLSVRMGREEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLSGGD SKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPSMRGSTPLDVA AASVMDNNELALALREPDLEKVVQYLAGCGLQSCVMLVHKGYPDIGWNPVEGERYLDFLR FAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGDGLLAAMEEAIKISLDASRDGPS PTSESSKTLDMLEEEEDDTIHMGNAIMTFYAALIDLLGRCAPEMHLIHAGKGEAIRIRAI LRSLIPIEDLVGVISIPFSMPNLAKDGLVVEPDMSAGFCPDHKAAMVLFLDRVYGIEDQN FLLHLLEVGFLPDLRAAASLDTVALSATDMALALNRYLCTAVLPLLTKCAPLFAGTEPFA SLIDSLLHTVYRLSKGCCLTKAQRDSIEECLLAVCGKLRPSMMQHLLRRLVFDVPLLNEH TKMPLKLLTNHYERCWKYYCLAGGWGNFGVTSDEELHLSRKLFWGIFDALSHKRYDHELF KLALPCLSAVAGALPPDYMESNYMAMMEKQSSMDSEGNFTPQPADTTNVTVPEKLDYFVT RYAEHNHEKLCIEKFSNGWSYGEQMCEISKSHPLLKQYKGLSEKDKEAYCSTVRESLKTM LSWGWSIDRIREGDPSSLHNKSRRISQASQQSFEGAPAFSPRPIDMSNVTLSRDMQSMAE LLAENYHNIWARKKKMELEAKGGGNHPLLVPYDTLTAKEKYKDREKAQDILKFLQINGYT VSRGVKSQELDTPAIEKRFAYNFLQQLITYVDQAQEHMVECDLGTKLKGEKIPHEQQMKF FGKVVLPLVDQYFKNHRLYFLSTAIHPISSGGHASNKEKEMVTSLFCKLGVLVRHRISLF GNNATSIVNCLQILGQSLDARTVMKTGLESVKAALRSHFDSVAEDLEKTQENLKLGQFTH SREQPRGVTQIINYTTFALLPVLSSLFEHIGQNMFGEDLILDDVQVSCYRILNSLYFLGT NKSIYVERQRPALGKCLAAFAAAFPVAFLEPHINKFNSFSIYNSKGSKDRAALGLPGLVG EVCPLIPNLEKSLEEIMELAESGMRYTQMPHVMEVVLPMLCSYMSHWWEYGPESIPDQAD SCCTAVTSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPIISKAKPQLLKTHFLPL MEKLKKKAAVVLMDEEQSRAEGRGEMSETELLIMDQFTVLVRDLYAFYPLLIRFVDYNRA RWLKESNPDAEELFRMVAEVFIFWSKSHNFKREEQNFVVQNEINNMSFLITDTKCKMSKG IVSDQERKKMKRKGDRYSMQTSLIVATLKRLLPVGLNICAPGEQELIALAKNRFTQKDTE DEVREIIRNNLHLQGKLEDPAIRWQMALYRDLPNHYEDTSDPEKTVERVLDIAHVLFHLD QVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIEAEEH YFEDKLIEDLAKPGEQEPSEEEEGVKHIDPLHQLIQLFSRTALTEKCKLDEDNLYMAYAD IMAKSCHDEEDEDGEEVKSFEEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGEMGPM VASTLKLGIAILNGGNSTVQQKMLDYLKDKKDVGFFQSLAGLMQSCSVLDLNAFERQNKA EGLGMVTEEGSVITHERGEKVMQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTV NVIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAIHVAKQVFNTLTEYIQGPC TGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEG NVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDAFKEYDPDGKGVISKRDF HKAMESHKHYTQSETEFLLSCAETDENELMDYEEFVERFHEPAKDIGFNVAVLLTNLSEH MPHDTRLQTFLELAESVLNYFQPYLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKES KRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAKMSDAGERSAVKEESEREKPDEEN PDMGFFSVTTVHMALLALRYNVMLLLKVLSMKSLKKQMKRIKNMTVKDMVTTLVSFYWSV LLGLLHVAFSVARGFCRIFYNTFMGGNLVEGAKTIKVSELLANMPDPTQDEVRGEGEDRE KRPSVKEDLSDLAVNTSETELLSDIFGLDLRREGGQYKITPHNPNASLTELLNSPVPSPT PLSAPQPELRRRHQSKSSSSEEKEATPETECETEKTPESVHVEKQEKQQKNEKMKPKVRK HRTSKSDEPDLQESAFLKKIIAYQRKLLNYFARNFYNMRMLALFVAFAINFILLFYKVST SSSVVEGREVVHTSSPADSSVQWDPLGGETMEAKEEVMERTGESLKPVTVRFVLEESSGY MEPMLRILAVLHTIISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIK GQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGHDRISELLGMDKAALDFSDAHKKRK PRKDSSLAAVLNSVDVKYQIWKLGVVFTDNSFLYLAWYMTMSILGHYNNFFFAAHLLDIA MGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGELPDMKCD DMLTCYMFHMYVGVRAGGGIGDQIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLII DAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFEISTLQEHNLANYLFFVMYLIN KDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14883 nt NT seq  +upstreamnt  +downstreamnt atggctgaaggaggagagggcgaggatgaaatccagttcctgcgaactgatgacgaggtg gtcctccagtgctcagcaacaatccacaaggagcaactgaaactctgtctggcagctgaa ggctttggaaacagactctgcttcctcgagtcgatctccaactccaagaatgtgcctcca gatttgtccatctgcacctttgtgttggagcagtcgctgtcagtacgagcccttcaggag atgctggccaacaccgaggagaaggctgacgggacgtcgcagggtggaggacatcgcacc ctactgtacggacacgctgtcctactacgacactcctacagtggaatgtacctgtgctgc ctgtccacctctcgctcatccacagacaaactggctttcgatgtgggacttcaggaagac acctcaggtgaggcgtgctggtggaccattcatccagcatcaaagcagcgctcagaggga gagaaggttcgagttggagatgacctcatcctggtcagcgtctcctctgagagatatttg catctgtcctacggtaacggcagtctccatgtagatgcagccttccagcagacactgtgg agtgtggctcccatctgttctggcagtgaagtagcacaaggtttcctgattggaggagat gtcctgcgcgtccttcatggtcacatggacgagtgtctcaccgttccatctggggagcat ggtgatgagcagaggaggacggtgcactatgaggggggagcagtgtccagtcatgcccgg tcgctgtggaggctggagacgctgcgagttgtgtggagcgggagtcatattcgctggggt cagccgttcagactgagacacgtgaccacggggaagtatctgagtctgatagaagacaag tctctgctgctgatggacaaagagaaagctgacgtcaagtcaacggccttctgcttcagg tcctccaaggaaaagttggaccctggcgtgaagaaggaggtggatgggatgggtgctcct gacattaagtatggtgactctgtgtgttacatccaacatgttgacacctacctgtggctc acataccagactgttgatgccaaatgtgcacgaatgagcggagtgcagagaaaggccatt atgcaccatgagggtcacatggacgacgggctaacagtgtctcggtctcaacacgaggag agccacaccgccagggtcatcagaagtactgtcttcctgttcaacctcttcatcaggggt ctggacacactaagaaaaaagggaaagggctctactttagatctaccaatagactcagtc agcctgagtctgcaggatctaattggctacttccagccacctggagatcagctggagcac gaagacaagcagaaccgactgagggctctgaagaaccggcagaacctcttccaagaagag gggataatcagcctggtattggagtgtattgatcgtcttcacgtctacagcagtgcagct cattttgctgaggcagtaggaagggaggctgcagaagcctggagctccatcctcaactcc ctctaccagctactggctgcactcatcagagggaacaggaagaactgtgcccagttttct ggctctttggactggctgattagcagattggagcgtctggaggcctcttctggtatattg gaggttcttcattgtgtgctggtggagagtcccgaggcactaaacataatcaaagaggga catatcaaatccatcatatgtctgctggacaagcatggacgcaaccacaaggttctggac gtgttgtgttcactgtgcgtgtgtcacggcgtcgcagtgcgctccaaccagcacctgatc tgtgacaacctgctgccaggaagagatctgttactgcagacccgcctgatcaaccacgta agcagcatgcatcccaatatcttcctgggagtcagcgatggctccgcccagtacaggaag tggtactacgagctgatcgtggatcaggtgctgccgtttgtcaccgcagaagccactcac ctcagagtgggctgggcgaacaccagcggctacgcaccctaccccattggaggggagggc tgggggggcaacggagtgggtgacgacctccactcttacagctttgatggactccacctt tggtcaggctgcatcgcgcggaccgtcagctcacccaatcagcatctcctgcgagccgaa gacgtggtgagctgctgcctggacctcagcgtgcccagcatctccttcaggatcaacggc cagccggttcagggcatgtttgagaacttcaactccgacggcctcttcttcccggtggcc agcttctctgccggagtcgaggtgcgcttcctcctcgggggtcgtcatggcgagttcaag ttcctccctcctcctggttacgccccctgctacgaggcggtgctgcccagggagaagctg aagctggaggccagtcaagaccagactgcagccaaagagctgctgggacccacaatcacc ttgagtcaggcagcattcaccccgacaccagtggacaccagccagattgttctgccacct cacttggagaggatcagggagaaacttgcagaaaacatccatgaactgtgggtgatgaac aagatagagctgggctggacctacggagcagtgcgtgatgataacaagcggcagcacccc tgtctggtggagttctccaagcttcctgaacaggagcggagctacaacttacaaatgtcc ctggagactctcaaaactctcctggctctgggctgccatgttggcctcgcagatgaacat gctgttgagaaagtgaagagcctgaaactgtcagcaacctatgagttgtcctgtggttac aaacctgctcctctggacctgagtcacatcaaactgacgtccacccaggaatccatggtg gacaaactggccgagaacgcacacaacgtctgggcaagagaccgcatccgccagggctgg acctacggcatccaacaggatgtaaagaaccgtagaaacccccgtttggtcccctacatt ctgctggatgagaggaccaagaagtccaacaaggacagtctcagagaggctgtccggact ctgctgggctacggatacaacctggaggcccctgaccaggaccatgcagctcaatctgac gtcagcaatatgtctgctgagaggttccgcatcttcagagcagagaaaacctactgtgtc agtgtcgggaagtggtactttgagctggaggtgttaacagctggagagatgagagtggga tgggccagaccaggatgtctgccagaccaggagctgggatctgatgaccaggcctttgtc tttgatggcttcaaggtccagcgctggcaccagggcaacgagcacttcgggcgtgcctgg cagacgggggacgtggtgggctgcatggtggatctgaatgagcacaccatgatgtttact ctcaatggagaagtgttgctggatgattctggatcggaactggcgttcaaggactttgaa gctggagaaggttttatcccagtttgcagtctcggtgtgtgtcaagtggggaagatgaac ttcggtaaagatgtgagcactctgaagtacttcaccatctgtggcctgcaggaaggctac gagccgttcgctgtcaacatgaaccgggacgtcaccatgtggctcagcaagaggctgcct cagtttgtgcctgttccccccaaccaccagcacatcgaggtgacgaggatagacgggaca gtggagtcgtgtccgtgcctaaaggtcacccagaggtcattcggctctcagaacagctac actgacatcaccttctacagactgagcatgcccatcgagtgttctgagtccagatccccg tcgaactgcagcatcttctcaacaaagaaggagctggaggactttgaaaccgtgtcagac tttgaggtcctgatgaaatcgtctcatggtcacaacggtcctaatgcacccgacagagac gagttcaacaaccacaaagattataaccaggagaagccatccaagctcaaacagcggttc acactgaagagaaacaagcctgacaacagctgtccttcatctgcccgtctgtcagaggag gtgatatctgacgacaaagacggctacgagatcctcatgcaagcccctgctcattactac tcggtgcggatcttccccggtcaggagcccagtaacgtgtgggtcggctgggtgacctcc gacttccatcagtacgacccgggcttcgagctgcacaaggtccgaactgtcaccgttacc ctgggagatgaaaagggcaaagttcatgagagtataaaacgcagtaactgttacatggtg tgggccggagagagcagcagtcctggtcaggggaggagcaacaacggcttggagatcggc tgcgtggttgacacaacgaacggtctgctgaccttcacggccaacggaaaagaactcagc acattctaccaggtggaacccagtacgaagcttttccctgcagtcttcgccaaggccacc agtcccaatgtcttccagtttgaactgggacgtatcaagaatgtgatgcctctgtcagct ggtctgttcaagagtgagaagaagaacccggttcctcagtgtcctccccggcttcatgtc cagttcctcactccggttttatggagtcgtgttcccaaccacttcctcaaggtctcagcc tccagagtgaacgaccgacatggctggctggtccagtgtaatgaacctctgcagttcatg tctctgcacatacctgaggaaaacaggtcgttggatatcctggagctgtctgagcagaag gacttgttaaagtttcattaccataccctcagactgtactctgcaatctgtgctctggga aacaaccgtgtggctcacgccctgtgctcccacgtcgacgaggctcagctcctgcaggct atagagaataagtacatgccaggtcggcttcgtgcgggctactacgacctcctcatcgac atccacctgagcagctacgccaccgctcgcctcatgatgaacaacgaatacatcgttccc atgacggacgagacgaagagcatcaccctgtttccagatgagaagaagaaacacggcctg ccgggcatcggactcagcacctccctgagacccagaatgcacttctcatcccccagtttt gtatgtgggaccggaccttcgtgtcggtccaacggtaacaacggatcaggagactgtttc cagtacagccctgaattccccttagatatcctgaaaattaaaaccatagagatgctgacg gaggcggtgcgggaggggagcatgcacgtacgggatccgatcggaggcagcaccgagttc ctcttcgtccccctcatcaagctcttctacaccatgctcatcatgggggttttccagaac ggagacctgaagaacatcctgcaactgatcgaaccgtccgtgttctctgagcgacgggac gggcaggaggagagtcacatggagctggaggcggtggagacggagggaggaggagaggat ggagagaggaagatacccaaagaaggactgttacagatgaagctaccagagcctgtaaaa ctccagatgtgccatgtgctgcagcacctgtgcgactgccaggtgcgtcatcgtatcgag gcggtggtggcattctccgatgactttgtggcttgtctccaagacaaccagcggttccgc tacaacgaggtgatgctggcactcaacatgtctgcagccctcactgccaagaagaccaaa gagttcagatctcccccacaggagcagatcaacatgttgctaaactttaaggatgagaag caggagtgtccctgtcctgaatacatccaggaccagctgctagacttccacgaagacctg atgaaacactgtggtatagagttggatgaggagagaggcatcgacgatgacggtgacttc accattcgaggtcgactcatgtcgctggtggagaaagtggcttatctgaagaacaagatg accaacctgccgttggagaagaaagaacggaaacccagtacattacaacagctgatctca aacacgatggtccgctgggctcaggagtcggtcatagaggatccggagctggtcagagcc atgtttgtcctgctgcaccgtcagtacgatggcatcggaggacaggtgagggctcttccc aaaacctacaccataaactcagtatccatcgaggacaccatcaacctgctggcggctctg ggtcagatcagatctctgctgagtgtccgtatgggccgagaggaggagaagctgatgatc agagggctcggtgacatcatgaacaacaaggtgttctaccagcatccaaacctgatgaga gctttgggaatgcatgagaccgtcatggaggtcatggtgaacgtgctcagtggaggagac tccaaggaaatcacctttcctaaaatggtggccaactgctgtcgttttctctgctacttc tgccgaatcagccgtcagaaccaaaaagccatgtttgaccatctgagctacctgctggag aacagcagcgttggactcgcgtctccatccatgcgagggtccactcctctggatgtggct gcagcatcagtcatggataataatgagctggctctggctttaagagagccggacctggag aaggtggtgcagtacctggccggctgtgggctgcagagctgcgtgatgctggtgcataaa ggataccctgacatcggctggaaccccgtggagggggagcgatacctcgacttcctgcgc ttcgctgtcttttgcaatggtgaaagtgtggaggagaatgccaatgtggtggtgaggctt cttattcgacgaccggaatgttttggccccgcccttcgaggtgaaggcggtgacgggctt ctggcagcgatggaggaagccattaagatctctctagacgcctccagagatggaccctct ccgacgtctgagagcagcaagacacttgacatgctggaggaagaggaagatgacaccatc cacatggggaatgccatcatgaccttctacgcagctctcattgacctactgggccgctgc gctccagagatgcatctgatccatgctggcaaaggtgaagcgatccggatcagagccatt ctgaggtctctgattcccattgaagacctggtgggagtcatcagcatcccattctccatg cccaacctggctaaagacgggttggttgtagagccagacatgtcagcaggtttctgtccg gaccataaagcagccatggttttgttcctggaccgggtctacggtatagaagaccagaac tttcttctccacctcctggaggtcgggttcttaccggatctgagagccgctgcctcgctg gacactgttgctctgagtgccacagacatggcgcttgctctcaacaggtatctgtgtaca gcagtgctgcctctcctgactaaatgtgctccgctgttcgcgggaacggagccgttcgcc tcgctgatcgactctctgcttcatacggtgtaccgcctctccaaaggctgctgcctcact aaggcccagagggactccatagaggagtgcctgctggctgtttgtggaaagctgaggcct tcaatgatgcagcatctgctgaggaggctagtgttcgacgtccctctgctgaacgaacac accaagatgcctctgaagctgttgaccaatcactatgagcgttgttggaagtattactgc cttgctggaggttgggggaactttggagtcacgtcagatgaagagcttcacctctccagg aaactgttctggggaatatttgatgctctgtcccacaagcggtacgatcacgagctgttt aagctggcgttgccgtgcctcagtgccgtggctggagctcttcctccagactacatggag tccaactacatggctatgatggagaaacagtcgtccatggactcggagggaaacttcact ccgcagcctgcagacaccaccaatgtgactgtcccagagaagcttgactattttgtaacc agatatgcagagcacaaccatgagaagttgtgtatagaaaagttttccaacggctggtca tacggagaacagatgtgtgaaattagcaagagccacccgctactgaaacaatacaaaggc ctctctgaaaaggataaagaggcgtactgctcgacggtcagagagtctctgaagacgatg ctgtcgtggggttggagcattgacaggatccgagagggagacccgagcagcctccacaac aagtccaggaggatatcacaggccagccagcagtcttttgaaggagctccagctttcagc ccgagacccatcgatatgagcaacgtcacgctgtccagagacatgcagtcgatggctgag ctgcttgcagagaattatcataatatctgggccaggaaaaagaaaatggagctggaagcc aaaggcggaggaaaccatcccctgcttgttccttatgacacactgacggccaaagagaaa tacaaagaccgagaaaaagcacaagacatcctcaagttccttcagatcaacgggtacact gtgtccagaggggtcaagtctcaggagctggatactccggcgatagagaaacgctttgcc tacaacttcctgcagcagctcatcacatacgtggaccaggcccaagaacacatggtggag tgcgatctgggaacgaagctgaagggagagaagattcctcacgaacagcaaatgaagttc ttcggaaaggtcgtcctgccactggtggatcagtactttaaaaaccacaggctgtacttc ctgtccacggccattcatccaatcagcagtggtggccacgcctccaacaaggagaaggag atggtgaccagtcttttctgcaaactgggagttcttgtcagacataggatatccttattt ggtaacaatgccacgtccatagtcaactgtctgcagatactgggacaaagcttggatgcc aggacagtgatgaagacaggactggagtcagtgaaagcagctctgcgctcacacttcgac agtgtggccgaggatctggagaagactcaagagaatctgaagctcggtcagttcactcac agccgagagcagccgcggggcgtcactcagatcatcaactacaccaccttcgccctgctg ccggtcctctcctccctgttcgagcacattggacagaacatgtttggagaagacctcata ttggatgatgtccaggtttcctgctacagaatcctcaacagcctctactttctgggaacc aacaaaagcatctatgtagagagacagcgtccagcattaggaaagtgtttagctgccttc gcagcagccttccctgtcgccttcctggagcctcacatcaacaagtttaacagcttctcc atctacaacagcaaaggaagtaaagacagagcagctttaggtcttcccgggctggtcggg gaggtttgtcctctgatcccaaacttagagaagtctctggaggagatcatggagctggca gagtcgggcatgagatacactcagatgccccatgtcatggaggtggtgttgccgatgttg tgcagctacatgtcgcactggtgggagtatggaccagagagcatcccggaccaggccgac agctgctgcacagccgtgacctccgaacacatgaacactctgctgggaaacattctgaag atcatctacaacaacctgggaatcgatgaaggcgcctggatgaagaggctggctgtcttc tctcagccgatcatcagcaaagccaaacctcagctgttaaagacccacttcttacctctg atggaaaaactcaaaaaaaaagcagcagtggtgctgatggatgaagaacagagccgggcg gaggggaggggggagatgtcagagacggagctgctcatcatggaccagttcaccgtactg gtccgagacctgtacgccttctacccgctcctcatacgattcgtcgactacaacagggcc cgatggctgaaagagtccaacccagacgcagaagagcttttccgaatggtggctgaggtt ttcatcttctggtccaaatctcataacttcaagagagaagagcagaactttgtggtgcag aatgagatcaacaacatgtccttcctcatcactgataccaagtgtaagatgtcaaaggga atagtttccgaccaggagaggaagaagatgaagaggaagggcgatcgatactccatgcag acgagtctgattgtcgccactctaaagcgtctgctgcctgtcggactcaacatctgtgct ccaggagaacaggagctcatcgcactggccaagaaccgcttcactcagaaagatacagag gatgaagttcgagagatcatcaggaacaatttgcacttacaagggaagctggaggatccg gctattcgctggcagatggctctgtacagagacctcccgaaccactacgaggatacttct gatccagaaaagaccgtggagagagtcctggacatcgctcacgtcctcttccacctggac caggtggagcatcctcagcgcagtaagaaggctgtgtggcacaaacttctgtccaaacag aggaagcgagctgtggtcgcgtgcttcaggatggcgccgctctacaacctgcccaggcac cgggctgtcaacctgttcctgcagggctatgagaagtcctggattgaagcagaggagcac tacttcgaagataaactcatagaggacctcgctaaaccaggtgaacaggagccatctgag gaggaggagggagtcaaacacattgatcccctgcatcagctcattcagctgtttagcaga acagccctcacagagaaatgtaaactggatgaggacaatctctacatggcctatgctgac atcatggctaagagttgccatgacgaagaggatgaagatggagaagaagtgaagagtttc gaagagaaggagatggagaagcagaagctgctgtatcagcaggctcggctgcatgaccgc ggagctgcagaaatggtgcttcaaaccatcagtgccagcaaaggtgagatgggccccatg gtggcatcgaccctgaagctgggcatcgctattctcaatggaggaaactccactgtacag cagaaaatgttggattatctgaaagacaagaaggatgtgggcttcttccagagtctggct ggtctcatgcagtcatgcagtgttttggatctaaatgcatttgagaggcagaacaaagca gaaggacttggaatggtgacagaggagggatcagtcatcactcatgagcgtggtgagaag gtcatgcaggatgatgagttcacctgtgaccttttccgcttcctgcagctgctctgtgaa ggacacaactcagacttccagaactacttgagaacacaaacggggaacaatacgaccgtc aacgtcattatctctactgttgactacctcctcagagttcaggagtctattagtgatttc tactggtattattctgggaaagacgtgattgacgagcagggacagaggaatttctcaaag gcaatacatgtggccaagcaggttttcaatacactcacagagtacatccagggtccgtgc actggcaaccagcagagtttggcccacagtcggctgtgggacgctgtggttggttttcta catgtcttcgctcatatgcagatgaaactgtctcaggactccagtcagattgagttattg aaggaactgatggatctgcagaaagatatggtggtcatgctgctgtctatgctggagggt aacgtggtgaacggaactatcgggaagcagatggtggacatgttggtggagtcctccaac aatgtggaaatgatcctcaagttcttcgacatgttcctcaaactgaaagacctgacctcc tcagacgccttcaaggagtatgaccctgatggaaaaggtgtcatctccaagcgggacttc cataaagccatggagagccacaaacactacacacagtctgagaccgagttcctgctctcc tgtgcagagactgatgagaacgaactgatggactatgaagagtttgtggaacgctttcat gagccagccaaggacattggcttcaatgtggcggttttgctgaccaacctgtcggagcac atgcctcatgacacccggctgcagaccttcctggagctggcagagagcgtcctcaactac ttccagccttacctgggccgtatcgaaatcatgggaagtgcgaagcgcatcgagagggtc tactttgagatcagcgagtccagtcggactcagtgggagaaacctcaggtcaaagaatct aagcgtcagttcatcttcgacgtggtgaacgaaggaggggagaaggaaaagatggagttg tttgtgaatttctgtgaggacaccatctttgaaatgcagctggcggcaaagatgtctgat gctggcgagcgctcggcggtgaaggaggagagcgagagggaaaaacccgatgaggagaac ccagacatgggcttcttctctgtcaccaccgtccacatggctctgcttgctctccgatac aatgtcatgctgttgctaaaggtgctgtccatgaagagcttgaagaagcagatgaagagg ataaagaacatgacagtgaaggacatggtgaccaccctggtctccttctactggtccgtg ctgctgggcctcctccatgtggcgttcagtgtcgctcggggattttgcagaatcttctac aacaccttcatgggaggaaacctggtggagggggccaagaccataaaggtgtcggagctg ctggccaacatgcccgaccccacccaggacgaggtgcggggtgaaggagaggaccgagag aagagaccgtcggtgaaggaggacctgtcggacctggcagtgaacaccagtgagaccgaa ctgctgtcggacatcttcggtctggacttaagaagggagggggggcagtacaagatcacc ccccataaccctaacgccagcctgacagagctcctcaactcccccgttccctccccgacg ccgctttcggccccccaaccggagctcagacggaggcatcagtcgaagagctcttcctcc gaggagaaggaggcaacgccagagactgaatgtgaaacagagaaaacacctgaaagtgta catgtagagaaacaagagaaacaacagaagaacgagaaaatgaagccaaaagtgagaaag catcgcacgtccaagtctgatgaaccggacctgcaggagtcagccttcctgaagaagatc atcgcctaccagaggaagctgctgaactactttgccaggaacttctacaacatgcggatg cttgcgctgtttgttgccttcgcgatcaacttcatcctcctcttctacaaggtttctact tcctcatctgtggtggagggacgggaggtggtgcacaccagcagcccagcagacagcagc gtccagtgggatccactggggggggagacgatggaggccaaggaggaggtgatggagagg accggggagtccctgaagcccgtcacggtccggtttgtcctggaggagagcagcggatac atggagcccatgttacgcatcctcgccgtcctgcacaccatcatctccttcttctgcatc atcggatactactgtctcaaggtccccctggtgatctttaagcgtgagaaggaggtagcc aggaagctggagtttgacggcctttacatcacagaacaaccgtctgaggacgacatcaaa ggacagtgggaccgactggtcatcaacacacaatctttccccaacaactactgggataag ttcgtaaagagaaaggtgatggataaatatggagagttttatggccatgaccgcatcagt gagctgctgggaatggacaaggctgcactggacttcagcgatgcccacaaaaagagaaag ccccgcaaagacagctccctggctgctgtgctgaactccgttgatgtcaagtaccagatc tggaaactgggggttgtattcacagacaattccttcctgtatctggcctggtatatgacc atgtccatcctgggtcactacaacaacttcttctttgctgcccatctgctggacatcgct atgggttttaagacgctgcgtaccatcctctcctcagtcacacacaatggaaaacagctg gtgttgaccgtcggcctgttggcggtggtggtgtacctctacacagtcgtggccttcaac ttcttcagaaagttctacaacaagagtgaagatggagaactgccagacatgaagtgtgac gacatgctgacatgctacatgttccacatgtatgtcggcgtgcgagcaggtggagggatt ggtgaccagatcgaggatccggcaggagacgagtacgagatctatcgaatcatctttgac atcaccttcttcttctttgtcattgtaattctcctggccatcatccagggattgatcatt gatgcgtttggagagctgagggaccagcaggaacaagtgaaagaagacatggagaccaaa tgttttatttgtggaataggtaacgactactttgacacagtgccacatggctttgaaatc tctacgctacaggagcacaacttagccaactacctattctttgtgatgtatctcatcaac aaagatgaaacagagcacacaggccaggagtcttatgtatggaagatgtaccaggagcgt tgctgggagtttttccctgctggggactgtttccggaaacagtacgaggatcagctcaac tga

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