Bos indicus (zebu cattle): 109553606 Help Entry 109553606         CDS       T04792                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism biu  Bos indicus (zebu cattle) Pathway biu04020   Calcium signaling pathway biu04024   cAMP signaling pathway biu04260   Cardiac muscle contraction biu04261   Adrenergic signaling in cardiomyocytes biu04371   Apelin signaling pathway biu04713   Circadian entrainment biu04911   Insulin secretion biu04921   Oxytocin signaling pathway biu04972   Pancreatic secretion biu05020   Prion disease biu05022   Pathways of neurodegeneration - multiple diseases biu05410   Hypertrophic cardiomyopathy biu05412   Arrhythmogenic right ventricular cardiomyopathy biu05414   Dilated cardiomyopathy biu05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:biu00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     109553606 (RYR2)    04020 Calcium signaling pathway     109553606 (RYR2)    04024 cAMP signaling pathway     109553606 (RYR2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     109553606 (RYR2)    04921 Oxytocin signaling pathway     109553606 (RYR2)   09153 Circulatory system    04260 Cardiac muscle contraction     109553606 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     109553606 (RYR2)   09154 Digestive system    04972 Pancreatic secretion     109553606 (RYR2)   09159 Environmental adaptation    04713 Circadian entrainment     109553606 (RYR2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     109553606 (RYR2)    05022 Pathways of neurodegeneration - multiple diseases     109553606 (RYR2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     109553606 (RYR2)    05412 Arrhythmogenic right ventricular cardiomyopathy     109553606 (RYR2)    05414 Dilated cardiomyopathy     109553606 (RYR2)    05415 Diabetic cardiomyopathy     109553606 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:biu04040]     109553606 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:biu04990]     109553606 (RYR2) Ion channels [BR:biu04040]  Voltage-gated cation channels   Ryanodine receptor    109553606 (RYR2) Domain-containing proteins not elsewhere classified [BR:biu04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    109553606 (RYR2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  109553606 NCBI-ProteinID:  XP_019809208 UniProt:  A0A6P5AQZ5 LinkDB All DBs Position 28:8446947..9082008 Genome browser AA seq 4992 aa AA seqDB search MTKRYITQCRGTKSEGNCTVSWFYWFDGTVQYFTPFPYDDEVVLQCTATIHKEQQKLCLA AEGFGNRLCFLESTSNSKNVPPDLSICTFVLEQSLSVRALQEMLANTVEKSEGKVDVEKW KFMMKTAQGGGHRTLLYGHAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEAC WWIIHPASKQRSEGEKVRVGDDLILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPIS SGSEAAQGYLIGGDVLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLE TLRVAWSGSHIRWGQPFRLRHVTTGKYLSLMEDKSLLLMDKEKADVKSTAFTFRSSKEKL DVGVRKEVDGMGTSEIKYGDSVCYIQHINTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGH MDDGLNLSRSQHEESRTARVIRSTVFLFNRFIRGLDALSKKVKASTVDLPIESVSLSLQD LIGYFHPPDEHLEHEDKQNRLRALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVA GREAGESWKSILNSLYELLAALIRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCV LVESPEALNIIKEGHIKSIISLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLP GRDLLLQTRLVNHVSSMRPNIFLGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWA STEGYSPYPGGGEEWGGNGVGDDLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCC LDLSAPSISFRINGQPVQGMFENFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPG YAPCYEAVLPKEKLKVEHSREYKQERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHL ERIREKLAENIHELWVMNKIELGWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLE TLKTLLALGCHVGISDEHAEEKVKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDK LAENAHNVWARDRIRQGWTYGIQQDVKNRRNPRLVPYALLDDRTKKSNKDSLREAVRTLL GYGYNLEAPDQDHAARAEVCSGTGERFRIFRAEKTYAVKAGRWYFEFEAVTAGDMRVGWC RPGCQPDQELGSDEXAFAFDGFKAQRWHQGNEHYGRSWQAGDVVGCMVDMTEHTMMFTLN GEILLDDSGSELAFKDFDVGDGFIPVCSLGVAQVGRLNFGKDVSTLKYFTICGLQEGYEP FAVNTNRDITMWLSKRLPQFLQVPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSSTD IMFYRLSMPIECAEVFSKTAAGGIPGTGLFGPKNDLEDYDVDSDFEVLMKTAHGHLVPDR GDRDKEATKPEFNNHKDYAQEKPSRLKQRFLLRRTKPDYSTSHSARLTEDVLADERDDYD YLMQTSTYYYSVRIFPGQEPANVWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHE SIKRSNCYMVCAGESLSPGQGRNNNGLEIGCVVDAASGLLTFTANGKELSTYYQVEPSTK LFPAVFAQATSPNVFQFELGRIKNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSR MPNQFLKVDVSRISERQGWLVQCXEPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTL RLYSAVCALGNHRVAHALCSHVDEPQLLYAIENKYMPGLLRTGYYDLLIDIHLSSYATAR LMMNNEFIVPMTEETKSITLFPDEKKKHGLPGIGLSTSLRPRMQFSSPSFVSINTEGYQY SPEFPLDILKAKTIQMLTEAVKEGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGVFHNED LKHVLQLIEPSVFKEAASPEEESEVAEKEPFVEDSKLEGAAEEENKGAKRPKEGLLQMKL PEPVKLQMCLLLQYLCDCQVRHRIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALT ARKTKEFRSPPQEQINMLLNFKDDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDRSLD GNNDLTIRGRLLSLVEKVTYLKKKQAEKPVESDSKKSSTLQQLISETMVRWAQESVIEDP ELVRAMFVLLHRQYDGIGGLVRALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEE EKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCR FLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALR EPDLEKVVRYLAGCGLQSCQMLVSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENAN VVVRLLIRRPECFGPALRGEGGNGLLAAMEEAIKIAEDPSRDGPSPTTGSSKTPDTEEEE DDTIHMGNAIMTFYSALIDLLGRCAPEMHLIHAAKGEAIRIRSILRSLIPLGDLVGVISI AFQMPTIAKDGNVVEPDMSAGFCPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRA AASLDTAALSATDMALALNRYLCTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKG CSLTKAQRDSIEVCLLSICGQLRPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCW KYYCLPGGWGNFGAASEEELHLSRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPP DYMESNYVSMMEKQSSMDSEGNFNPQPVDTSNITIPEKLEYFINKYAEHAHDKWSMDKLA NGWIYGEIYSDSSKVQPLMKPYKLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSM ALYNRTRRISQTSQVSVDAAHGYSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKL ELEAKGGGNHPLLVPYDTLTAKEKAKDREKAQDILKFLQINGYAVSRGFKDLELDTPSIE KRFAYSFLQQLIRYVDEAHQYILEFDGGSRSKGEHFPYEQEIKFFAKVVLPLIDQYFKNH RLYFLSAASRPLCSGGHASNKEKEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQ TLDARTVMKTGLESVKSALRAFLDNAAEDLEKTMENLKQGQFTHTRNQPKGVTQIINYTT VALLPMLSSLFEHIGQHQFGEDLILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGEC LAAFAGAFPVAFLETHLDKHNIYSIYNTKSSRERAALNLPANVEDVCPNIPSLEKLMEEI VDLAESGIRYTQMPHVMEVVLPMLCSYMSRWWEHGPENNPGRAEMCCTALNSEHMNTLLG NILKIIYNNLGIDEGAWMKRLAVFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEED HLKSEARGDMSEAELLILDEFTTLARDLYAFYPLLIRFVDYNRAKWLKEPNQEAEDLFRM VAEVFIYWSKSHNFKREEQNFVVQNEINNMSFLIMDTKSKMSKAAVSDQERKKMKRKGDR YSMQTSLIVAALKRLLPIGLNICAPGDQELIALAKNRFSLKDTEDEVRDIIRSNIHLQGK LEDPAIRWQMALYKDLPNRTEDTSDPEKTVERVLDIANVLFHLEQKSTCMRRRYYNLGST VEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHY FEDKLIEDLAKPGAEPPEEDEGTKRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIM AKSCHDEEDDDGEEEVKSFEEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGETGPMV AATLKLGIAILNGGNSTVQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAE GLGMVTEEGSGEKVLQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTV DYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSL AHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTI GKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESH KHYTQSETEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRL QTFLELAESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFD VVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESDLNERSANKEESEKEKPEEQGPRMGF FSIMTVKSALFALRYNILTLMRMLSLKSLKKQMKKVKKMTVKDMITAFFTSYWSILMSLL HFVASVFRGFSRIIGSLLLGGSLVEGAKKIKVAELLANMPDPTQDEVRGDGEEGERKTLE GALPSEDLTDLKELSEESDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLMSNPVPIPEV QEKFQEQKAKEEEKEEKEESKSEPEKAEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEV PESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSVVEGKELPT RSSSENARVSSLDSSSPRIIAVHYVLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKV PLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMD KYGEFYGRDRISELLGMDKAALDFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFT DNSFLYLAWYMTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLA VVVYLYTVVAFNFFRKFYNKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPA GDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGN DYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAG DCFRKQYEDQLN NT seq 14979 nt NT seq  +upstreamnt  +downstreamnt atgactaagcgctacatcacacaatgtcgaggtactaaatcggaaggaaactgcacagtg agctggttttattggtttgatggaacagttcagtactttactcctttcccttatgatgat gaagtggtcctgcagtgtaccgcgaccatccacaaagaacaacagaaactatgcttggcg gcagaaggatttggcaacagactttgcttcttggagtccacttcgaattccaagaatgtc cctccagacctctccatctgcaccttcgtgctggagcagtccttgtctgtccgggccctg caggagatgttggctaacactgtggaaaagtctgaagggaaggttgatgtggaaaaatgg aaattcatgatgaagactgctcaaggtggtggccaccgaacgctcctctacggtcatgca atactgctgcggcattcctacagtggcatgtatctgtgctgcctgtccacctctcggtct tcaactgataagctggcttttgatgttggcttgcaagaggatacaacaggtgaagcttgt tggtggatcatccatcctgcctctaagcagcgctcagaaggagaaaaagtgcgggttgga gatgacctcatcttagtgagcgtgtcctctgaaaggtacctgcacttgtcttacggtaay ggcagcttgcacgtggatgctgctttccagcagaccctctggagcgtggcccccatcagc tcaggaagtgaagcagcccaagggtatctgattggtggtgacgtcctcaggttgcttcat ggacacatggatgaatgcctcactgtcccttcaggagaacacggtgaagagcagcggaga actgttcattacgaaggtggtgctgtatcggttcaygcacgttccctgtggcgactggag acactaagagttgcgtggagtggaagccacataaggtggggacaaccttttcgactacgc catgtcacaacaggaaaatacttgagtctcatggaagacaaaagccttctactcatggac aaagaaaaagctgatgtcaaatcaactgcatttaccttccgatcttccaaggaaaaattg gatgtaggagtgagaaaagaagttgatggcatgggaacctctgaaataaaatatggagac tcagtatgttatatacagcatatcaatacaggcttgtggctracttaccagtctgtggat gtgaaatckgtgagaatgggatccatacaacgtaaggctattatgcatcatgaaggacac atggatgatggcctaaatttatccagatctcagcatgaagaatcacggacagcacgygtc atccggagcacagtcttcctttttaatagatttattaggggccttgatgctctcagcaaa aaggtgaaagcttccacagtagacttacctatagagtctgtaagtctgagtctgcaggac cttattggctacttccacccaccagatgagcatttagagcatgaagataagcagaacaga ttacgagctctgaagaataggcagaatctcttccaggaagagggaatgatcaaccttgtg ctcgagtgtatagacaggctgcatgtgtatagcagtgctgcacacttcgcwgatgttgct gggagagaagcaggggaatcttggaaatcgattctgaattctctgtatgagttgctggcg gcattaattagaggaaatcgtaaaaactgtgctcaattttctggctcccttgactggtta atcagccgactggaaagactggaagcttcttctggtattcttgaagttttacactgtgtg ttagtagaaagtccagaagctctaaatattattaaagaaggccatataaaatccattatc tcacttttagacaagcatggaagaaatcacaaggttctggatgtcttatgctctctctgt gtttgccatggagtagcagtccgttctaaccagcatctcatctgtgacaatcttctgcca ggaagagacctgttattgcagacacgccttgtgaaccacgtgagcagcatgagacccaat atttttctgggtgtcagtgaaggatctgcacagtataagaagtggtattatgagttgatg gtggaccacactgagccattcgtgactgctgaagccactcacctgcgagtgggctgggct tccacagaggggtactcaccctaccctggagggggtgaagagtggggtggaaatggtgtc ggagatgacctcttctcctacggatttgatggccttcacctctggtcaggttgtattgcc cggacggtcagctcaccaaaccagcatctcttgagaactgatgatgtcatcagttgctgt ctagatctaagtgccccaagcatctccttccgaattaatggacaacctgttcaaggcatg tttgagaatttcaacattgatggcctcttctttccagttgtcagtttctctgcaggaatc aaagtacgctttctgcttggggggagacatggagaatttaaattccttcctccacctggg tatgctccttgttatgaagctgtactgccaaaagagaagttgaaagtggagcacagccga gagtacaagcaagaaaggacttacacgcgggacctcctgggccccacggtttccctgaca caagctgccttcacaccaatcccagtggacaccagccagattgtgttgcctccccacctg gagaggatacgagaaaaactggcagagaatatccatgagctctgggtgatgaataaaatt gaacttggctggcagtatggtccggttagagatgacaataagagacagcacccgtgtctg gtggagttctccaagctgcctgaacaggaacgcaattacaatttacagatgtcacttgag accctgaagacgttgttggctttaggatgtcatgtgggtatatcagatgaacacgctgaa gaaaaagtgaaaaaaatgaagctgccaaagaattaccaactgacaagtggatacaagcct gccccaatggacctgagctttattaaactcaccccatctcaggaggctatggtggacaag ctggcagaaaatgctcataacgtgtgggctcgggatcgaattcgacaaggctggacctat gggatccaacaggatgtaaagaacagaagaaaccctcggcttgttccctatgcccttcta gatgaccgaactaagaaatccaataaggatagcctccgtgaggctgtacgcacactgctg ggatatggctacaacctggaggcacctgatcaagatcatgctgccagagctgaagtgtgc agcggcacgggagagaggttccgcatcttccgtgctgagaaaacatatgctgtgaaggct ggaaggtggtattttgaattcgaggcggtcactgctggagacatgcgagttggctggtgc aggccagggtgtcaacctgatcaggagcttggctcagatgaaygtgcctttgcttttgat ggcttcaaggcccagcggtggcaccagggcaatgagcactatgggcgctcttggcaagct ggcgacgttgtggggtgtatggttgacatgacagaacacaccatgatgttcacactgaat ggcgaaatccttcttgatgattccggttcagagctggctttcaaggactttgatgttggt gatggattcatacctgtgtgtagcctgggagtggctcaagtgggcaggctgaactttgga aaggatgtcagcaccttgaaatatttcaccatctgtggcttacaagagggctatgaacca tttgccgttaacacaaatagggatattaccatgtggctgagcaagaggcttcctcaattt ctccaagttccatcaaaccatgaacatattgaggtgaccagaatagatggcaccatagac agttccccgtgtttaaaagtcactcagaagtcctttggctctcagaacagcagcacggat atcatgttttatcgtctgagcatgcccatcgagtgtgcagaggtcttctccaagactgca gctggagggatccctggcaccgggctctttgggcccaagaatgatctggaggattatgat gtggattcagactttgaggttctcatgaagacagctcacggccatctggtgccagatcga ggagatagagacaaagaagctacaaaaccagagtttaataaccacaaggattatgctcag gaaaaaccctctcgtctgaaacagaggtttttgcttcgaagaacaaagccagattatagc accagccattctgcacgactcactgaagatgtccttgcagatgagagggatgactatgat tacttgatgcaaacgtccacgtactattactcagtgagaatctttcctggacaagaacct gccaatgtctgggtgggctggatcacatccgatttccatcagtatgatacaggctttgac ttggacagagttcgtacagtgaccgtgactctgggagatgaaaaaggaaaggtgcacgaa agcatcaaacgcagcaattgctacatggtgtgtgcgggtgagagcctgagcccggggcaa ggacggaacaacaacggcctggagattggctgcgtggtggatgctgccagtgggctgctc accttcacggccaacggcaaggaactgagcacctattatcaggtggaaccaagcacaaaa ttatttcctgcagtttttgcacaagctacaagtcctaatgtttttcagtttgagttggga agaataaagaatgtgatgcctctctcagcgggattattcaagagtgagcacaaaaatcct gtgccacagtgtcccccacgtctccacgtgcagtttctctcacatgtcctgtggagcaga atgcccaaccagttcttgaaggtagacgtctctcgaataagtgaacgccagggctggctg gtgcagtgcrtggagcctctgcagttcatgtcacttcacatcccagaggaaaacagatct gtggacatactggaactgacagagcaggaggaactactgaaattccactaccacactctc cggctctactcggccgtctgcgcgctcgggaaccaccgggtggcccacgccttgtgcagc cacgtggacgagccgcagctgctctacgccatcgagaacaagtacatgcccggcttgctg cgcaccggctactacgatctgctgattgacatccacctcagctcctacgccaccgccagg ctcatgatgaacaacgagttcatcgtccccatgaccgaggagaccaagagcatcaccctc ttcccggatgagaagaaaaagcacgggctcccgggcatcggcctcagcacctccctcagg ccgcggatgcagttttcctccccgagttttgtcagcattaataccgagggttaccagtac agcccagagttcccgctggacatcctgaaggccaagaccatacagatgctgacagaagcc gtgaaagagggcagccttcatgcccgagaccccgttgggggcaccactgagttcctcttc gtccctctcatcaagctgttctataccctgctcatcatgggtgtcttccacaacgaggac ttgaaacacgtcttgcagttgattgagcctagtgtgttcaaggaagccgccagcccggag gaggagagcgaggtggcggagaaggaaccctttgtggaagactccaagctggaaggagcc gctgaggaagaaaacaaaggggctaagaggcccaaggagggcctgctccaaatgaaactg ccagagccagtaaaattgcagatgtgcctgctacttcaatacctctgtgactgccaggtc cggcaccggatagaagccattgtggccttttcagatgactttgtagccaagctccaagac aatcaacgattccgatataatgaagttatgcaagccttaaacatgtccgctgcactcaca gccaggaaaacaaaggaattcagatccccgcctcaagaacagatcaatatgcttctcaat tttaaggatgacaaaagtgaatgtccatgtcctgaagaaatccgagaccaactcttggat tttcacgaagatttgatgacacattgtggaattgagctggatgaagataggtctctggat ggaaacaatgatttaactattagaggacgcctgctgtccttggtagaaaaggtgacatac ctgaagaagaagcaagcggaaaagccagttgagagtgactccaagaagtcatccactctt cagcagttgatttctgagaccatggtccgatgggctcaagagtctgttattgaagaccct gaattggtgagggccatgtttgtattgctccatcgacagtatgatggcattgggggtctg gtacgggctctgccaaagacctacactataaatggtgtttctgtggaggataccatcaat ctgctggcatctcttggtcagattcgttctctgctaagtgtgagaatgggcaaagaggaa gagaaacttatgattcgtggattaggggatatcatgaacaataaagtgttttaccagcat cctaatctcatgagggcccttgggatgcatgagacagtgatggaggtcatggtgaatgtc cttggaggtggagagtccaaggaaatcacttttccgaagatggtggccaactgttgccgt tttctctgttacttctgtcgtataagcaggcagaatcagaaagctatgtttgatcatctg agttatttactggaaaacagcagtgttggtcttgcctcaccagctatgagaggttcaaca ccactggatgtggcagcagcctcggtgatggataataatgaactagctttagctttgcgg gagccagatctggaaaaggtggttcggtatttggctggttgtggactgcagagytgccag atgctagtgtcaaagggttatccagacattgggtggaatccagttgaaggagagagatat cttgactttctcagatttgctgtcttctgtaatggggaaagcgtggaggagaatgcaaat gtagtggtgagattgctcatccggaggcctgagtgtttcggtcccgccttgaggggggaa ggtgggaatggcctgcttgcagccatggaagaagccataaaaatagccgaggatccctct agagatggtccctcaccaactaccggatccagcaaaacccctgatacagaagaggaagag gatgataccatccacatgggaaatgccatcatgaccttttattcagctttaattgacctg ttaggacgatgtgctcctgaaatgcatttgattcatgctgccaaaggagaagccatcaga atcaggtctattttgagatctctgattccattgggagatttggtgggagtgatcagcatc gcttttcagatgcccacaatagccaaagatgggaatgtggtggagcctgacatgtctgcg gggttttgtccagatcacaaggcagccatggttttgttccttgacagggtctatggaatt gaggttcaagatttcctcctccatcttctygaggttggctttctgccagatctccgggct gctgcttctttagacacggctgctttgagtgctacagacatggccctggcgctcaatcgg tacctgtgcacagccgtgttacccttgttaacaaggtgtgctcctctttttgctggcacc gagcaccatgcttctctcattgactcattacttcacactgtgtacaggctttctaagggc tgctcacttaccaaagctcaacgggattccatagaagtgtgtttactctctatttgtggc caattgagaccttctatgatgcaacacttactcagaagattagtatttgatgtcccatta ttaaatgaacatgcaaagatgcctcttaagctgctgacaaatcattatgaaagatgctgg aaatattactgcctgcctggagggtggggcaactttggagctgcctcagaagaagaactt catttgtcaagaaagctgttctggggcatctttgatgccctgtctcaaaagaaatatgaa caagaacttttcaaactggcactgccttgcctgagtgcagttgcgggagctttgcctcca gactacatggagtcaaattatgtcagtatgatggaaaaacagtcatcaatggattctgaa gggaactttaatccacaacctgttgatacctcaaatattacaattcctgagaagttggaa tacttcattaacaaatatgcagaacatgcccatgacaagtggtcaatggataagttggca aatggatggatttatggagaaatatattcagactcatctaaagttcaaccattaatgaag ccatataaactattatctgaaaaggaaaaagaaatttatcgctggccaatcaaagaatct ttaaaaactatgctggcttggggatggagaattgaaaggacccgagagggagacagcatg gccctttataaccgtactcgtcgtatttctcagacaagtcaggtttctgtagatgccgcc catgggtacagcccacgagccattgacatgagcaatgttacactatccagagatctgcac gctatggcagaaatgatggctgaaaactaccataatatatgggcaaagaaaaagaaactg gaactggaggccaaaggaggtggaaaccatcccctactggtaccttatgatacactgaca gccaaagagaaagccaaggatagggaaaaagcacaggacatcctcaagttcctgcagatc aatggctatgctgtatccagagggttcaaagacctggaactggacacaccttctattgag aaacggtttgcctatagtttccttcagcaactcattcgctatgtagacgaggcccatcag tatatcctggagtttgatggtggcagcagaagcaaaggagaacatttcccttatgaacaa gaaatcaagttctttgctaaagtcgttcttcctttaattgatcagtatttcaaaaaccac cgtttatacttcttatctgcagcaagcagacctctctgttctggaggacatgcatcaaac aaagagaaagaaatggtgactagcctattctgcaaacttggagttcttgtcaggcatagg atttcactatttgggaacgatgcaacatcaattgtcaactgtcttcatattttgggtcag actttggatgcaaggactgtgatgaagactggcctggagagtgttaaaagtgcactcaga gccttcctggacaatgccgcagaggatctggagaagacgatggagaatcttaagcagggc cagttcacccacacccgaaaccaacccaaaggtgttactcagattatcaattataccacg gtggcactgttaccaatgctgtcatcattatttgagcatattggccagcatcagttcgga gaagatctcatattggaagatgtacaggtgtcatgttatagaattctgactagcttgtat gctttgggaaccagcaagagtatttatgtggaaaggcaacgttctgcattgggagaatgt ctggctgcttttgctggtgcctttcctgtagcatttttggaaactcacctggacaagcac aatatttactccatctacaatacaaagtcttcgagagagagagcagctcttaatttgcct gctaaygtggaagatgtttgtccaaatataccgtctttggagaagctcatggaagaaatt gtggacttggctgagtccgggattcgctacacacagatgccacatgtgatggaagttgtc ctgcccatgctttgtagttacatgtctcgttggtgggagcatgggcctgagaataatccg ggaagggctgagatgtgctgtacagctctgaactcagagcacatgaacacgctgctgggc aatatcctgaaaatcatatataataacttgggtattgatgagggagcctggatgaagagg ttagcagtgttttcccagcctattataaataaagtgaaacctcagctcttgaaaactcat ttcttgccrttaatggagaagctcaagaaaaaggcagcaatggtggtatcagaagaggac catctgaaatctgaggccaggggagatatgtctgaagccgaacttctcatcctagatgag ttcaccacactggccagagatctctatgccttctatccrctcctgattagatttgtggac tataacagggcaaaatggctgaaagagcctaaccaagaagcagaagatcttttccgcatg gttgctgaggtgtttatctactggtcaaaatcccataatttcaaaagggaggagcagaac tttgtggtgcagaatgaaatcaacaatatgtctttccttattatggacaccaagtcaaag atgtccaaggcagctgtttctgatcaggaaaggaagaaaatgaagcgcaaaggggaccga tattccatgcagacatctcttattgtggcygctctgaagcggttgctgcccattgggttg aacatctgtgcccctggggaccaggagctcattgcactggccaaaaatcgctttagtctg aaagacactgaggatgaagttcgagatataatccgcagtaatattcacttacaaggcaag ttggaggatcctgctattagatggcaaatggctctttacaaagacttacccaataggaca gaagacacttcagatcctgagaagacagtggaaagggtcttggatatagcaaatgtactt tttcatcttgaacagaaatctacatgtatgcgccggagatattacaatctgggaagtaca gttgagcatcctcagagatcaaaaaaggccgtgtggcacaaactgctctctaagcagagg aaacgagcygtggttgcttgcttccggatggctcctttatataatctgccgaggcatcgg gctgtcaatctctttcttcagggatatgaaaagtcttggattgagacagaagaacattac tttgaagataaattgatagaagacttagcgaaacctggagcagaacctccagaagaagat gaaggaactaagagggttgatcctcttcatcagctgatccttctgtttagtcgaacagct ttaacrgagaaatgcaaactggaggaagattttttatatatggcttatgcagatattatg gcaaagagttgtcatgatgaggaagatgatgatggggaagaggaagtgaagagttttgaa gaaaaagaaatggaaaagcaaaagcttctataccaacaagccaggctccatgaccgcggt gctgctgagatggtgctgcagaccatcagtgccagcaaaggtgaaactggacccatggtg gctgctactttgaaacttggaattgctatcttaaatggagggaactctacagtacagcag aaaatgcttgactacctcaaggagaaaaaggaygtgggcttctttcagagcctggctggc ctgatgcagtcatgcagtgtcctcgacctaaatgcatttgagcgacaaaacaaagctgaa ggacttgggatggtgactgaggaaggatcaggagaaaaggttctgcaggatgacgaattc acctgtgacctcttccgcttcttgcaactgctttgtgagggacacaactcagattttcaa aattatctgagaactcagactggcaataatacaactgtcaacataatcatctctactgta gactaccttctgagagttcaggaatcaattagtgatttctattggtattactctggaaaa gatgtcattgatgaacaaggacaaaggaatttctccaaagctattcaagtggcaaaacaa gtctttaacactcttacagagtatattcagggtccttgcactggcaaccagcagagtttg gctcacagcaggctctgggatgctgtggtgggttttcttcatgtatttgcccacatgcag atgaagctgtctcaggactccagtcaaattgagctactgaaagaattgatggatcttcag aaggacatggtggtcatgttgctgtccatgttggaaggcaatgttgttaatggcaccatt ggcaaacagatggttgatatgctcgtggaatcttccaacaacgtggagatgattctcaag ttttttgacatgttcttaaagctcaaggacttgacgtcttctgatacyttcaaagagtat gaccccgatggtaagggagttatttccaagagggactttcacaaagccatggagagccat aaacactacacccagtccgagactgagtttctcctgtcctgtgcagagacagatgaaaat gaaaccctggactaygaagaatttgtcaaacggttccacgagcctgccaaggacattggc ttcaatgtggcagtgcttctgacaaacctctccgaacacatgcccaatgacacccggctg cagactttcctggaattggccgagagcgtgctcaattacttccagcccttcctgggccgc atmgagatcatgggcagtgccaagcgcatcgagagggtgtattttgaaatcagtgagtcc agccgaacccagtgggaaaagccccaggtcaaggaatccaaaaggcaatttatatttgac gtggtcaatgaaggaggggagaaagagaagatggagctcttcgtgaacttctgcgaggat accatctttgagatgcarctggcggctcagatttcagagtcagatctgaatgagaggtca gcgaataargaggagagtgagaaggagaagccggaggagcagggtccgaggatgggtttc ttttccatcatgacggtcaagtccgccctgtttgccctcaggtacaatatcttgaccctt atgcggatgctcagcctgaaaagcttgaagaagcagatgaagaaggtgaagaagatgaca gtgaaggacatgatcacagccttctttacatcctactggagtattttgatgagcctcctg cactttgtagccagcgttttcagaggcttctctcgcatcatcggcagcctcctgctggga ggaagcctggtcgaaggtgcgaagaagatcaaagtggcggagctcttggccaacatgcca gaccccacacaagatgaggttcgaggagacggggaggagggggagaggaaaaccctggaa ggggccctgccctctgaagacctgacggacttgaaggaactgtcagaggagagtgacctg ctttcygatatctttggcttggacctgaagcgagaaggagggcagtacaaactgattcct cacaatcccaatgctggcctgagtgacctcatgagcaaccccgtccccatcccagaggtg caagaaaagttccaggagcagaaggcaaaagaagaagaaaaggaagaaaaagaagaaagc aaatccgaaccygagaaagctgaaggagaagatggagaaaaagaagaaaaagccaaagaa gacaagggtaaacaaaaactgaggcagctccacacacacagatatggagagccagaagtt cctgagtcagcattctggaagaaaatcatagcctatcaacagaaacttctaaactatttt gctcgcaacttctacaacatgagaatgttagccttatttgtcgcatttgcgatcaatttc atcttgctcttttataaggtctccacttcttctgtggttgaaggaaaggaactacccact cgcagttcaagtgaaaatgccagagttagcagcttggacagcagctcgcctagaatcatc gcagtgcactatgtgctggaggagagcagtggctacatggagcccacactgcggatatta gccattctgcacacggtcatctctttcttctgtatcattggatactactgcttgaaagtc ccactggttatttttaagcgagagaaggaagtagctcgaaaattggaatttgatgggctt tatattacagaacagccttcagaagatgatattaaaggccagtgggatagactcgtaatc aacacacagtcatttcccaacaactactgggacaaatttgttaaaagaaaggttatggat aaatatggagagttctatggccgagacagaatcagcgagttactcggcatggacaaagct gccttggacttcagtgatgcccgggaaaagaagaagccaaagaaagacagctccctgtca gctgtactgaactctattgatgtgaagtatcagatgtggaaactaggagtcgttttcact gacaactccttcctctaccttgcctggtatatgaccatgtccattcttggacactacaac aactttttttttgctgctcatcttctggacattgctatgggattcaagacgttaagaacc atcttgtcatcagtaactcacaatggcaaacagcttgtattaactgttggcttattggct gttgttgtatacctatatactgtcgtggcattcaattttttccgaaaattctacaataaa agtgaagatggcgatacaccagacatgaagtgtgatgacatgctaacgtgctatatgttc cacatgtatgttggagtacgtgctggagggggtatcggtgatgaaatcgaagatccagct ggtgatgagtatgagatatatcgaatcatctttgacatcaccttcttcttttttgtaatt gtcattctcttggccataatacaaggtttaatcatcgatgcttttggggaactaagagac caacaggaacaggtcaaagaagacatggagaccaagtgcttcatctgtgggataggcaat gattactttgacaccgtgccacatggctttgaaacccacactttacaggaacacaacttg gccaattatctgttttttctgatgtatctcataaacaaagatgaaacggagcacacagga caggaatcttatgtttggaagatgtatcaagaaaggtgctgggaatttttcccagccgga gactgtttccggaaacagtatgaagaccagctaaattaa

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