KEGG   Bos indicus (zebu cattle): 109555027
Entry
109555027         CDS       T04792                                 
Symbol
ARAF
Name
(RefSeq) serine/threonine-protein kinase A-Raf isoform X1
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
biu  Bos indicus (zebu cattle)
Pathway
biu01521  EGFR tyrosine kinase inhibitor resistance
biu01522  Endocrine resistance
biu04010  MAPK signaling pathway
biu04012  ErbB signaling pathway
biu04068  FoxO signaling pathway
biu04270  Vascular smooth muscle contraction
biu04650  Natural killer cell mediated cytotoxicity
biu04720  Long-term potentiation
biu04726  Serotonergic synapse
biu04730  Long-term depression
biu04810  Regulation of actin cytoskeleton
biu04910  Insulin signaling pathway
biu04914  Progesterone-mediated oocyte maturation
biu04928  Parathyroid hormone synthesis, secretion and action
biu05010  Alzheimer disease
biu05022  Pathways of neurodegeneration - multiple diseases
biu05034  Alcoholism
biu05160  Hepatitis C
biu05161  Hepatitis B
biu05200  Pathways in cancer
biu05205  Proteoglycans in cancer
biu05208  Chemical carcinogenesis - reactive oxygen species
biu05210  Colorectal cancer
biu05211  Renal cell carcinoma
biu05212  Pancreatic cancer
biu05213  Endometrial cancer
biu05214  Glioma
biu05215  Prostate cancer
biu05218  Melanoma
biu05219  Bladder cancer
biu05220  Chronic myeloid leukemia
biu05221  Acute myeloid leukemia
biu05223  Non-small cell lung cancer
biu05224  Breast cancer
biu05225  Hepatocellular carcinoma
biu05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:biu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    109555027 (ARAF)
   04012 ErbB signaling pathway
    109555027 (ARAF)
   04068 FoxO signaling pathway
    109555027 (ARAF)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    109555027 (ARAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    109555027 (ARAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    109555027 (ARAF)
   04914 Progesterone-mediated oocyte maturation
    109555027 (ARAF)
   04928 Parathyroid hormone synthesis, secretion and action
    109555027 (ARAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    109555027 (ARAF)
  09156 Nervous system
   04726 Serotonergic synapse
    109555027 (ARAF)
   04720 Long-term potentiation
    109555027 (ARAF)
   04730 Long-term depression
    109555027 (ARAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    109555027 (ARAF)
   05205 Proteoglycans in cancer
    109555027 (ARAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    109555027 (ARAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    109555027 (ARAF)
   05212 Pancreatic cancer
    109555027 (ARAF)
   05225 Hepatocellular carcinoma
    109555027 (ARAF)
   05226 Gastric cancer
    109555027 (ARAF)
   05214 Glioma
    109555027 (ARAF)
   05221 Acute myeloid leukemia
    109555027 (ARAF)
   05220 Chronic myeloid leukemia
    109555027 (ARAF)
   05218 Melanoma
    109555027 (ARAF)
   05211 Renal cell carcinoma
    109555027 (ARAF)
   05219 Bladder cancer
    109555027 (ARAF)
   05215 Prostate cancer
    109555027 (ARAF)
   05213 Endometrial cancer
    109555027 (ARAF)
   05224 Breast cancer
    109555027 (ARAF)
   05223 Non-small cell lung cancer
    109555027 (ARAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    109555027 (ARAF)
   05160 Hepatitis C
    109555027 (ARAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    109555027 (ARAF)
   05022 Pathways of neurodegeneration - multiple diseases
    109555027 (ARAF)
  09165 Substance dependence
   05034 Alcoholism
    109555027 (ARAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    109555027 (ARAF)
   01522 Endocrine resistance
    109555027 (ARAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:biu01001]
    109555027 (ARAF)
Enzymes [BR:biu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     109555027 (ARAF)
Protein kinases [BR:biu01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   109555027 (ARAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase C1_1 RBD Kinase-like zf-RING-like ABC1 Pkinase_fungal Kdo
Other DBs
NCBI-GeneID: 109555027
NCBI-ProteinID: XP_019811139
UniProt: A0A6P5BL87
LinkDB
Position
X:complement(56264851..56275844)
AA seq 573 aa
MSVYDSLDKALKVRGLNQDCCVVYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTM
HNFVRKTFFSLAFCDFCLKFLFHGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRRQFYHSV
QDLSGSSRQHEVPSNRPLNEPLTPQSPSLSPASSCTQHRDPEHFSFPAQANTPLQRIRST
STPNVHMVSTTAPMDSGLIQLTGQNFNTDAAGNRGGGDGAPRGSPSPASVSSGRKSPHSK
SPSEQRERKSLADDKKKVKNLGYRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDV
AVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHH
LHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATV
KTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIG
SRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRS
LPKIERSASEPSLHRTQADELPACLLSAARLVP
NT seq 1722 nt   +upstreamnt  +downstreamnt
atgagtgtctatgactctctagacaaggcactcaaggtgcggggtctcaatcaagattgc
tgtgtggtttaccggctcatcaaggggcgaaagacagtcaccgcctgggacacagccatt
gctcccctggatggcgaggagctcattgtggaggtcctcgaagacgtccccctgaccatg
cacaattttgtacggaagacgttcttcagcctggccttttgtgacttctgccttaagttt
ctgttccatggcttccgctgccaaacctgtggatacaagttccaccagcattgttcctcc
aaggtccccacagtctgtgtcgacatgagtaccaaccgccgacagttctaccacagtgtc
caggatttgtccggaagctccagacagcacgaggttccctcaaaccgccccctgaatgag
ccgctcacccctcagagtcccagcctttcccctgccagctcctgcacccagcaccgcgac
cccgagcacttctccttccctgcccaggccaacacccctctccagcgcatccgctccaca
tccacccccaatgtccacatggtcagcaccacagcccccatggactccggcctcatccag
ctcactggccagaatttcaacactgatgctgctgggaatagaggtggtggtgatggagcc
ccccgggggagccccagcccagccagtgtgtcctcgggaaggaagtccccacattccaag
tccccatcagagcagcgggaacggaagtcgttggctgatgacaagaagaaagtgaagaat
ttggggtaccgggactcgggctattactgggaggtgccacccagtgaggtgcagttgctg
aagaggatcgggacgggctcgtttggcaccgtgtttcgcgggcggtggcatggtgatgtg
gccgtgaaggtgctcaaggtggcccaacccacagctgagcaggcccaggccttcaagaac
gagatgcaggtgctcaggaagacacgtcacgtcaacatcttgctgttcatgggcttcatg
acccggccaggatttgccatcatcacacagtggtgtgagggctccagtctctaccaccac
ctgcatgtggctgacacacgcttcgacatggtccagctcattgatgtggcccgccagact
gctcagggcatggactacctccatgccaagaacatcatccaccgagatctcaagtctaac
aacatcttcctgcacgaggggctcacggtgaagatcggggacttcggcctggctacagta
aagacgcggtggagtggggcccagcccttggagcaaccctcgggctctgtgctatggatg
gcagctgaggtgatccgtatgcaggacccgaacccctacagcttccagtcagatgtctac
gcctatggggttgtgctctatgagctcatgaccggctcactgccttacagccacattggc
agccgagaccagattatctttatggtgggccgtggctatctgtccccggacctcagcaaa
atctccagcaattgccccaaggccatgaggcgcctgctgtctgactgcctgaagttccag
cgggaggagcggcccctttttccccagatcctggccacgattgagctgctgcagcggtca
ctccccaagattgagcggagtgcctccgaaccttccttgcaccgtacccaggctgatgag
ttgcctgcctgcctactcagcgcagcccgccttgtgccttag

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