Bos indicus (zebu cattle): 109557793
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Entry
109557793 CDS
T04792
Symbol
NOS3
Name
(RefSeq) nitric oxide synthase, endothelial
KO
K13242
nitric-oxide synthase, endothelial [EC:
1.14.13.39
]
Organism
biu
Bos indicus (zebu cattle)
Pathway
biu00220
Arginine biosynthesis
biu00330
Arginine and proline metabolism
biu01100
Metabolic pathways
biu04020
Calcium signaling pathway
biu04022
cGMP-PKG signaling pathway
biu04066
HIF-1 signaling pathway
biu04071
Sphingolipid signaling pathway
biu04151
PI3K-Akt signaling pathway
biu04370
VEGF signaling pathway
biu04371
Apelin signaling pathway
biu04611
Platelet activation
biu04915
Estrogen signaling pathway
biu04921
Oxytocin signaling pathway
biu04926
Relaxin signaling pathway
biu04931
Insulin resistance
biu04933
AGE-RAGE signaling pathway in diabetic complications
biu05415
Diabetic cardiomyopathy
biu05417
Lipid and atherosclerosis
biu05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
biu00001
]
09100 Metabolism
09105 Amino acid metabolism
00220 Arginine biosynthesis
109557793 (NOS3)
00330 Arginine and proline metabolism
109557793 (NOS3)
09130 Environmental Information Processing
09132 Signal transduction
04370 VEGF signaling pathway
109557793 (NOS3)
04371 Apelin signaling pathway
109557793 (NOS3)
04066 HIF-1 signaling pathway
109557793 (NOS3)
04020 Calcium signaling pathway
109557793 (NOS3)
04071 Sphingolipid signaling pathway
109557793 (NOS3)
04022 cGMP-PKG signaling pathway
109557793 (NOS3)
04151 PI3K-Akt signaling pathway
109557793 (NOS3)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
109557793 (NOS3)
09152 Endocrine system
04915 Estrogen signaling pathway
109557793 (NOS3)
04921 Oxytocin signaling pathway
109557793 (NOS3)
04926 Relaxin signaling pathway
109557793 (NOS3)
09160 Human Diseases
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
109557793 (NOS3)
05418 Fluid shear stress and atherosclerosis
109557793 (NOS3)
05415 Diabetic cardiomyopathy
109557793 (NOS3)
09167 Endocrine and metabolic disease
04931 Insulin resistance
109557793 (NOS3)
04933 AGE-RAGE signaling pathway in diabetic complications
109557793 (NOS3)
Enzymes [BR:
biu01000
]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
1.14.13.39 nitric-oxide synthase (NADPH)
109557793 (NOS3)
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Gene cluster
GFIT
Motif
Pfam:
NO_synthase
FAD_binding_1
Flavodoxin_1
NAD_binding_1
Motif
Other DBs
NCBI-GeneID:
109557793
NCBI-ProteinID:
XP_019814885
UniProt:
A0A6P5BRE3
LinkDB
All DBs
Position
4:117833543..117851821
Genome browser
AA seq
1205 aa
AA seq
DB search
MGNLKSVGQEPGPPCGLGLGLGLGLCGKQGPASPAPEPSRAPAPATPHAPDHSPAPNSPT
LTRPPEGPKFPRVKNWELGSITYDTLCAQSQQDGPCTPRRCLGSLVLPRKLQTRPSPGPP
PAEQLLSQARDFINQYYSSIKRSGSQAHEERLQEVEAEVASTGTYHLRESELVFGAKQAW
RNAPRCVGRIQWGKLQVFDARDCSSAQEMFTYICNHIKYATNRGNLRSAITVFPQRAPGR
GDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDE
APELFVLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFSAAPFSGWYM
STEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINLAVLHSFQLAKVTIV
DHHAATVSFMKHLDNEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYILSPAFRYQPD
PWKGSATKGAGITRKKTFKEVANAVKISASLMGTLMAKRVKATILYASETGRAQSYAQQL
GRLFRKAFDPRVLCMDEYDVVSLEHEALVLVVTSTFGNGDPPENGESFAAALMEMSGPYN
SSPRPEQHKSYKIRFNSVSCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYP
HFCAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAKAAFQASCETFCVGEEAKA
AAQDIFSPKRSWKRQRYRLSAQAEGLQLLPGLIHVHRRKMFQATVLSVENLQSSKSTRAT
ILVRLDTAGQEGLQYQPGDHIGICPPNRPGLVEALLSRVEDPPPPTESVAVEQLEKGSPG
GPPPSWVRDPRLPPCTLRQALTFFLDITSPPSPRLLRLLSTLAEEPSEQQELETLSQDPR
RYEEWKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPNAHPGEVHLTVA
VLAYRTQDGLGPLHYGVCSTWLSQLKTGDPVPCFIRGAPSFRLPPDPYVPCILVGPGTGI
APFRGFWQERLHDIESKGLQPAPMTLVFGCRCSQLDHLYRDEVQDAQERGVFGRVLTAFS
REPDSPKTYVQDILRTELAAEVHRVLCLERGHMFVCGDVTMATSVLQTVQRILATEGDME
LDEAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERHLRGAVPWAFDPPGP
DTPGP
NT seq
3618 nt
NT seq
+upstream
nt +downstream
nt
atgggcaacttgaagagtgtgggccaggagcccgggcccccctgcggcctggggctgggg
ctgggcctcgggctatgcggcaagcagggcccagcctccccggcacctgagcccagccgg
gcccccgcacccgccaccccgcacgcgccagaccacagcccagctcccaacagccccacg
ctgacccggcctccggaggggcccaagttccctcgcgtgaagaactgggagctggggagc
atcacctacgacactctgtgcgcgcagtcccaacaggacgggccctgcactcccaggcgc
tgcctgggctccctggtgttgccccggaaactgcagacccggccctccccgggacctcca
cccgctgagcagctgctgagccaggccagggacttcatcaaccagtactacagctccatc
aagaggagcggctcccaggctcacgaggagcggcttcaggaggtggaggccgaggtggca
tccacgggcacctaccacctccgagagagtgagctggtgttcggggccaagcaggcctgg
cgcaaygcaccccgctgcgtgggccgcatccagtgggggaagctgcaggtgtttgatgcc
cgggactgcagctcagcacaggagatgttcacctacatctgcaaccacatcaagtaygcc
accaaccgcggcaaccttcgctcggccatcacagtgttcccgcagcgcgccccgggccgc
ggagacttccggatctggaacagccagctggtgcgctacgcaggctacagacagcaggat
ggctctgtgcgtggggacccagccaaygtggagatcacggagctctgcatccagcacggc
tggacccccggaaacggccgcttcgacgtgctgcccctgctgctccaggccccagacgag
gctccagagctctttgttctgccccccgagctggtccttgaagtgcccctggagcacccc
acactggagtggttcgcggccctgggcctgcgatggtatgccctcccggccgtgtccaac
atgctgctggaaatcgggggtctggagttctccgcggcccccttcagcggctggtacatg
agcacggagattggcacgcggaacctgtgtgaccctcaccgctacaatatcctggaggat
gtggccgtctgcatggacctcgacacgcggaccacctcgtccctgtggaaggacaaggcg
gccgtggagatcaacctggctgtgctgcacagctttcagctcgccaaggtgaccatcgtg
gaccaccacgccgccacggtgtccttcatgaagcacctggacaacgagcagaaggccagg
gggggctgccccgccgactgggcctggatcgtgccccccatctcaggcagcctcacgccc
gtcttccaccaggagatggtcaactacatcctgtcccctgccttccgctaccagccagac
ccctggaaagggagcgcgaccaagggcgccggcatcaccaggaagaagacctttaaggaa
gtggccaacgcggtgaagatctctgcctcactcatgggcaccctgatggccaagcgagtg
aaagcaaccatcctgtacgcctctgagaccggccgggcccagagctacgctcagcagctg
gggaggctcttccggaaggccttcgatccccgggtcctgtgcatggatgagtatgacgtg
gtgtccctggagcacgaggcactggtgctggtggtgaccagcacctttgggaatggcgat
cccccggagaatggagagagttttgcagctgccctgatggagatgtcggggccctacaac
agctccccacggccggaacagcacaagagttacaagatccgcttcaacagcgtctcctgc
tcagacccgctggtgtcctcctggcggcggaagagaaaggagtccagcaacacagacagc
gcgggggccctggggaccctcaggttctgtgtgttcggactgggctcccgggcgtacccc
cacttctgcgccttcgcgcgagcggtggacacccggctggaagagcttggaggggagcgg
ctgctgcagctgggccagggcgatgagctctgcggccaggaagaggccttccgtggttgg
gcaaaggcggcattccaggcctcctgtgagacsttctgcgttggggaggaggccaaggct
gctgcccaggacatcttcagccccaaacggagctggaaacgccagaggtaccggctgagc
gcccaggccgagggcctccagctgctgccaggcctgatccacgtgcacagacggaagatg
tttcaggccacagtcctctcggtggaaaatctgcaaagcagcaagtccacccgggccacc
atcctggtgcgcctggacactgcaggccaggaggggctgcagtaccagccgggggaccac
ataggcatctgcccgcccaaccggccgggcctggtggaggcgctgctgagccgcgtggag
gacccgccaccgcccaccgagtctgtggctgtggagcagctggagaaaggcagcccaggc
ggccctcctcccagctgggtgcgggacccacggctgcccccgtgcacgctgcgccaggct
ctcaccttcttcctggacatcacctccccacccagcccccggcttctccgactgctcagc
accctggccgaagaacccagcgagcagcaggagcttgagaccctcagtcaggacccccgg
cgctacgaggagtggaagtggttccgctgccccacgctgctggaggtgctggagcagttc
ccgtccgtggcgctgcccgccccgctgctcctcacccagctgcccctgctgcagccccgg
tactactctgtcagctcggcccccaacgcccaccccggagaggtccacctcacagtggcc
gtgctggcgtacaggacccaagatgggctgggccccctacactacggggtctgctccaca
tggctgagccagctcaagactggagaccccgtgccctgcttcatcaggggggctccctcc
ttccggctgccgcctgacccctacgtgccctgcatcctcgtgggccctggcactggcatc
gcccccttccggggattttggcaggagaggctgcatgacattgagagcaaagggctgcag
cccgcccccatgaccctggtgttcggctgccgctgctcccaactcgaccatctctaccgc
gacgaggtgcaggacgcccaggagcgcggggtgtttggccgcgtcctcaccgccttctcc
cgggaacctgacagccccaagacctacgtacaggacatcctgagaaccgagctggctgcc
gaggtgcaccgcgtgctgtgcctcgagcggggccacatgtttgtctgcggcgatgtcact
atggcaaccagcgtcctgcagacggtgcagcgcatcttggcgacagagggcgacatggag
ctggacgaggcgggcgacgtcatcggcgtgctgcgggatcagcaacgctatcacgaggac
attttcggcctcacgctgcgcacccaggaggtgacaagccgtatacgtacccagagcttt
tccctgcaggagcggcatctgcggggcgcggtgccctgggccttcgacccgcccggccca
gacacccccggcccctga
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