Bos indicus (zebu cattle): 109564061 Help Entry 109564061         CDS       T04792                                  Symbol SYNE1 Name (RefSeq) LOW QUALITY PROTEIN: nesprin-1   KO K19326   nesprin-1 Organism biu  Bos indicus (zebu cattle) Pathway biu04820   Cytoskeleton in muscle cells Brite KEGG Orthology (KO) [BR:biu00001]  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     109564061 (SYNE1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:biu03036]     109564061 (SYNE1) Chromosome and associated proteins [BR:biu03036]  Eukaryotic type   Centrosome formation proteins    LINC complex     109564061 (SYNE1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Spectrin Spectrin_SYNE1 SYNE1 CH KASH PBP_N Motif Other DBs NCBI-GeneID:  109564061 NCBI-ProteinID:  XP_019823167 UniProt:  A0A6P5CDJ8 LinkDB All DBs Position 9:complement(92644326..93162397) Genome browser AA seq 8821 aa AA seqDB search MAASRAASRAPRDIANVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDG VKLLALLEVLSGQKLPCEQGRRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPS IVLGLMWTIILYFQIEELTSNLPQLQALSSSTSSVDSMVSSETASPPSKRKVATKIQGNA KKALLNWVQYIVTKQSGIEVKDFGRSWRSGVAFHSVIHAIRPELVDLEKVKGRPNRENLE EAFTIAETELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKQYPDIHSTGSDGQENDEILP SFPSFTNSIQILKREDRLILKEMKVWIEQFERDLTRAQMTDSSLQDKYQSFKHFRVQYEM KRKQIEHLLQPLHRDGKLSLDQALVKQAWDRVSSRLFDWHMQLDKSLPAPLGTIGAWLYR AEVALREEITIQQVHEETANTIQRKREQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPD QLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGGRDSVELLL QNYISFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVE VRSVRSMLEEVIANWDRYGNTVASLQAWLEDAEKMLNQSEHAKKDFFRNLPHWIQQHTAM NDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYARADELDRMKKEYNDCVTIL SDFATEAHRKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKMITKTAHLITKEISQE EANEMFATMSGLKEQLTKVKDCYSPLLSESQQLLVPLEELEKQMTAFYDSLGKIDEIMTV LEHEAQSSPLFKQKHQELLACQESCKKAMTQIEKGSQSVQKFVTLSNVLKHFDQTKLQRK IADTHVAFQNMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRVAQEGLEEKGDPEDLL KRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQRGLQEAVRKLHKQWKDLQAEAPYHLL HLKIEVEKNRFLASVEECRAELDRETKLVPQEGSEKIIKEHRIFFSDKGPHHLCEKRLQL IEELCLKLPVRDAVRNTPETCHVTLKELRAAIDRTYVKLVGDPDKWKDYTSRISEFSSWI SAKETQLKGIKNETIDTANQGEVKCALEEIRSGITKKGETLSWLKSRLKILIEVSSEDEA QKQGDELAKLSSSFKALGTLLSEVEKMLSNFGDCVQYKEIVKSSLEELITGSKZVQEEAE KILDTENLFEAQQLLLHHQQKTKRINAKKKDVQQQITQAQKGEGGLPGRVQEELQKLEST LDSVEHSREKQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELE QTKEFSKRTEGIAVQAENLVKEASEIPLGPKNKQLLQQQAKSIKEQVKKLEDTLEEDIKT MEMVKNKWDHFGTNFETLSVWITEKEKELNALETSSSAMDTQINQIKVMIKEIESKISSI TGLEEEAQSFAQFVTTGESARIKAKLTQIRRYWEELREHAQSLQGIILGHLSQQQKFEEN LKKIQQSVSEFEDKLADPVKICSSATETYKVLQEHMDLCQALESLTSTVAALSASARKVS NRDASIQEAATVQRSFEGLLGRAKERQTELEKLLARWQRLEKELSTFLTWLERCEAIASS PEADISADRVKVESELQSIQVLQNEVVSQASIYSNLLQLKESLFSVASKDDVKMMKLQLD QLDERWRDLPQIISKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQ AALTRHKDHAAEVESKKGELQSLQGHLAKLGALGRAEDLHLLQGKAEDCLQLFEEASQVV ERRQHALSQLAEFLQSHASLSESLHQLRQTVESTHSMNKKQSDLLERDLNDAIRNVKTLE SAAISLDGLLTKAQYHLKSGGSEQRTSCRATSDHLSVELERIQNLLGTKQSEADALAVLK KAFRDQKEELLKSIEDIEERTDKERLKDLTRQALQQRLRVFNQLEDELNSHEHELCWLKD KAKQIAQKDVAFAPEVDKEINRLEVTWNDTKKLIHENQGQCCGLIDLMREYQNLKSAITK VLENASNVIATRTTVKDQEDLKWALSKHEAAKNEMCNKQKDLDNFTSKGKQLLSELKKIH SGDFIVVKTDMESTVDKWLDISEKIEENMDRLRVSLSIWDDILTSKDEIDGWSNHSVPQL TESISNLNDSLRAEEFLKEFESEVKKKALRLEELHSKVNDLKELTKNPETPPDLQFIEAD LRQKLEHAKEITEEAKGTLKEFTAQSAQVEKFINDTATWLTKLEESLMNCAQXETCEGLK KVKDIQKELQSQQSNISMTQENLNSLCRKYHSVELGSLGSAMTGLIKRHEAVSQSCSKTQ ASLQDSLEKHFNESMQLFQEWFSGIKAAAKESSDRTGDSKVLEAKLRDLQNILDSVSDGQ SKLDAVTREGQTLYAHLSKQIVSSIQEQVTKANEEFQAFLKQCLKDRQALQDCALELGSF EDQHRKLNLWIHEMEERLSTENLGESKQHIPEKKNEVHKIEMFLGELLAARESLDKLSQR GQLLSEEGHGAGKESRLCSQLLTSYQNLLRMTKEKLRSCQVALQEHEALEEALQSMWSWV KDMQDRLASAESTVGSKDALERRLLQVQEILLMKGEGEVKLNMAIGKGEQALRSSNKEGQ KVIQTQLQTLKDVWANIVDSSXHAQSTLESVISQWNDYLEWKNQLEQWMESVDQKVEHPL QPQPGLKEKFSLLDHFQSVVSEAEDHAGALQRLTAKARELYQKTEDEALTDXAQEELKTQ FNDILTVSKEKMRKVEEIVKDHLMYLDAVQEFTDWLHSAKEELHRWSDMSGDSPATQKKL SKIKELMDSREIGASRLSRVESLAPAVKRNTTASGCELLDTEMQALRADWKQWEDSVFQT QTSLENLVSQMALSEQEFSGQVAQLEQALEQFSALLTSWTQQLALLEGKNTDKELVECWQ KGREILDALQKAEPQTENLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQN KEQILQQRFLRAFKDFQQWLVNAKITTAKCFDIPQNINEVSTSLQKIQEFFSESENGQHK LNTMLSKGELLCTLLTKEKASGIQAKIATAKEDWKNFHSNLHQKESALENLKIQMKDFEV SAEPVQDWLSKTEKMVHESTNRLYDXPAKRREQQKLQSVLEEINCYEPQLRRLKEKAQQL WEGQAASRSFMHRVSQLSSQYLALSNVTKEKVSRLDRIVAEHNQFSLGIKDLQDWMXDTV HMLDSYCHPTSDKSVLDSRMLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPAIQ QQLASVKDMWASLLSAAIXCKSQLEGALSKWTSYQDDVRQFCSWMDGVEASLNASERQHA ELREKTAALGKAKLLNEEVLSHGSLLETIEVKGAGMTEHYVTQLEFQDLQERYGAIRERT KEAVTKSEKLVRLHQEYQRDLKAFEAWLEKEQDKLDRYSVLEGDAHTHETALRDLQELQV RCAEGQALLNSALHTREEVIPSGIPQTEDRALESLRQDWQAYQQRLSETRTQFNNVVNKL RLVEQKFQQVDEWLKTXEEKVSLRTARQSSRAAKEMQLHQMKKWHEEITAYRDEVEEVGA RAQEILDESHVSSRMGCQATQLTSKYQALLLQVLEQIKFLEEEIQSLEESELSLSSYSDW YSSTHKNFKNVAAKIDKVDKAMMGKKMKTLEGLLKDMEKGQSLLKSAREKGERALKYLED AEAETLRKEIHDHVERLKELTSTVRKEHMTLEKGLHLTKEFSDKYKALTQWIAEYRDILH GPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQ SDYQDLCSAAKEHVCSLEAKVRDHEDYNSELQEVEKWLLQMSGRLVAPDLMETSSLETIT QQLARHKAMMEEIAGFEDRLNDLKTKGDNLISQCADHLQAKLKQNVHAHLQGTKDSYSAI CSTAQRVYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLKPGANPPLSRAEAVKQVKHFR ALQEQARTYLDLLCSMCDLSNSSVKTTAKDIQQTEQMIEQRLAQAQNLTQGWEEIKHMKA ELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQCKQASVNTITEKVDELT KKQESPEHKEISHLNDQWLDLCLQSNNLCLQREEDLQRTRDYHDRMNVVEGFLEKFTTEW DNLARSDAESTAVHLEALKKLALALQERKKAIEDLKEQKQKMIEHLNLDDKELVKEQTSH LEQRWFQLEDLVKRKIQVSITNLEELSVVRSRFQELMEWAEEQQPNIAEALKQSPPPDMA QNLLMDHLAICSELEAKQMLLKSLTKDADRVMADLGLXERQIIQKALSDAQRHVSSLSDL VGQRRKYFNKALSEKTQFLMAVFQATSQIQQHEHKIMFREHICLLPDDVSKQVKTCKSAQ ASLKTYQNEVTGLWAQGRELMKGVTEQEKSEILGKLQELQSVYDTVLQKCSHRLQELEKN LVSRKHFKEDFDKACHWLKQADIITFPEINLMNETAELHTQLAKYQHILEQSPEYENLLL SLQRTGQAILPTLNEVDHSYLDEKLHALPLQFNVIVDLAKDKFYKVQEAMLARKEYASLI ELTSQSLRDLEDQFSRMSQIPGHLSVEEAMSLQDGWRALGGEVAGLTEAVDELNQKKESF RSTGQPWQPDKMPQLITLYHRLKRQTEQRVSFLEDTTSXYQEHEKMCLQLEKQLEAVRME QSKVNEETLPAEEKLKVYHSLAGSLQNSGILLKRVTRHLEDLISHLDPAAYEKAKHQLQA WQEELKLLTSAIGATVTECESRMVQSRDLQTELSRSLEWLRSVEAALSGPLCLDPNLRDI QEEIRKVQIHQEEVQSSLRIMNALSNKEKEKFTRAKELISADLQRTLAELSELDGALQEA LRTRQTTLTQIYSQCQRFYQVFQAANDWLEDAHEMLQLTGNGLDVESAEESLKSHMEFFS AEDQFHSNLEELQGLVANLDPLIKPTGKEDLAQKMASLEEKSQXIMQDSHAQLELLQRCA AQWQDYQKAREEVIELMNEAEKKLSEFSLLKTSSSHEAEEKXSEHKALVSVINSFHEKIV ALEGEASELERTGNDASKAAISRSTTAVWQRWTRLRAVAQDQEKLLEDAVDEWTSFNNKV KKASEVIDQLQDKLPGSSAEKASKAELVTLLEYHDTFILELERQQLALGMLRQQALSMLQ DGVTPSPGGEPPTVQEITAMQDXCLNMQEKVKKNGKIVKQELKEREVVETXISSVKSWVQ ETKEYLGNPTIEIDAQLEELKILLTEAINHQQNVEKMAEEQKNKYLGLYTILPSELSLQL AEVALDLGTTHDQIQDKVKEVEQSKAMSQEFSQQIQKIARDLTTILTKLRAKTDNLVQAK TDQKVLGEELDGCHLKLMELDKAVQKFSEQNGQLGKPLAKKIGKLTELHQQTIRQAENQL SKLNQAASHLEEYNEILELILRWIEKTKILVHGKIAWNSASQLREQYISHQTMLEESEDI HNDLEAMTEKLQYLDSVYHTETMSQQVADLGRETEELRQVIKIRLQSLHDAAKDMKKFEA ELRNLQVALEQAQTTLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVHAVQVRQSALRIP EDVVASLPLCHAALHLQEEASRLQHTAIQQCNIMQEAVVQYEQYEQEMQHLQELIEGAHR EIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVT EVEGLAEGTEDLDGELLPATSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPAC RSPSPVANTDASVNQDIAYYQALSPERLQTDAAKVPPSTLPPQELYEPGLEPSATAKLDD LQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIEMKLSESLEQGRSPESQ MAEHQALMDEILMLQEEISELQSALADELVSESPESEPAEQLALQSTLTVLAERMSTIKM KASGKRQLLEEKLNDQLEEQRQEQALNRYRCEADQLDHWLLSTKATLDIALGSPKEPMDM EAQLVDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAVKLRTLKGSLLEL QRALQDRQLHIQGTAQEKEESDADLAATQSPGVQEWLAQARSAWTHQRQSSLQQQKELEQ ELAEQKSLLQSVASLGEEILTQHSAAETSGGVGEKPDVLSQELGMEGEKSPAEDQMRMKW ESLHQEFSTKQKLLQNVLEQEQEQMLYSRPNRLLSGVPLYKGDGQAQDKSAVTSLLDGLN QVFEEVSSQGGGTKKQNIDLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCIFNQ ETLAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQM KERLQQILNFQNDLKVLVTSLADHKYIILQKLAKMFEQPVAEQIEAIQQAEDGLKELDAG IIELKRRADKLQIEQPSMQELSKLQDMYDELMMTIGSRRSGLNQNLALKSQYERALQDLA DLLETGREKTAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVPRE TQFHTDLMAQASAVLKGAHKRGVELEYILETWSQLEKEHWELSRQLEVVESSTPSVGLVE ESEDRLIDRIALYQHLKSSLNEYQPKLYQVIDDGKRLLISVSCSDLESQLNQLGEHWLSD TNKVSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHL NGFLEFSKEVDAKSTLKSSVLSTGNQLLRLKKVDTAALRSELSHIDGQWNDLLTNIPAVQ EKLHQLQMDKLPSRHAISEVMTWISLMESVIQKDEENIKNSIGYKTIHEYLQKYKGFQID INCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAERLGAMNKSWQILQGLVTEKIQLLEG LLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNAMKDCQDLEDLIKAKEKEVE KIEQNGLALVQNKKEEVSGIVRSTLQELNQTWANLDHMVGQLKILLKSVLDQWSHHKVAF DEINSCLMESRYSLSRFCLLTGSLEAVQVQVDNLQNLQDDLEKQEKSLQKFGSVTNQLLK ECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLRASKALLQLWQRYKDYFKQCAATVQQQE GRTNEFLKAATDKDIGDDEVATWIQDCNDLLKGLGPIQDSLVVLHELGGQLKQQVDASAA SAIQSDWLSLRQQLHALEQALCKQQTVLQAGVLDYETFTKSLEALETWIVEAEEILQGQD PSHSSDLSTIQERMEELKGQMLKFSSMVPDLDRLNELGYRLPLNDKEIKRMQNLNRRWSL ISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHEL FQAEMFSRQQILHSIIFDGQHLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGVID SQIHQWQRYREMAEKLRKWLVEVSCLPVSGLGTVQIPLQQARALFDQVQFKEKVFLRQQG SYILTVEAGKQLLLSADSGAEATLQAZLAEIQEKWKSASVCLEEQKKKLAGLLQDWEKCE NGIADSLEKLRTFKKRLSQPLPDHHEELHAEQMCCKELENTVGSWTXDLAQLTLLKKALC AYISADDISILNERMELLQRQWEELCHQLSLRXQQVSERLNEWAVFSEKNKELCEWLTQM ESKVSQNGDILIEEMIEKLRKDYQEEIAIAQENKIQLQQMGERLARASHESKASEIEYKL GKINDRWQHLLDLMAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCDS EEIQKKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRR WRNICAMSMERRLKIEETWRLWQKFLDDFSHFEDWLKISERXAAFPSSSGVLYTVAKEEL KKFEAFQRQVHESLTQLELINKQYRRLARENRTDAAGSLKQTVHKGNQRWDNLQKRVTSI LRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLN HNKIEQIIAQGEQLIEKSEPLDAAVIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDE HDLSDRELELDEAGTLSDLHWRDTSTDGVLSPQPSSNPSLSLAQPLRSERSGRDTPASVD SIPLEWDHDYDLSRDLESAVSRTLPSEDEEGPEDKDFYLRGAVGLSDVVIPENPEAYVKL TESAIRNSSGDPGALESQIRQLGKALDDSRFQMQQTENIIHSKTPTGPELDSGYRGYMKL LGECSGSIDSVKRLEHKLTEEEDHFPGFVNLNSTETQTAGVIDRWELIQAEALSKELRMK QKPQRRQQLDSDLNSVLTWLRETEGDLEQLQRLQLSTDIQSIALQIQKLKELQKAVDQRK AIILSIHLCSSEFTQPGREESQDLQDRLSQMNGRWERVCSLLEEWRGLLQDALMQCQDFH EMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLKQIRHELLESQLKVASLQDMS CQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDMSSSQQDLSSWSSAD ELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVNSPHSRSIRGGSDSSLSEPQPARS GRAFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCALSNNFARSFHPMLRYTNGPPP L NT seq 26466 nt NT seq  +upstreamnt  +downstreamnt atggccgcctccagggcagcctcgcgggcccctcgggacatcgccaacgtgatgcagagg ctgcaagatgagcaagagatagtacaaaaacgtactttcacaaaatggatcaactctcat ctggccaagcggaaacccccaatggtggtagatgatctttttgaagacatgaaagatggt gtgaagctacttgctctgctggaagtcctgtctgggcagaaactgccatgtgaacaaggg cgccggatgaagagaattcatgccgtggcaaacattggcacagcactgaagttccttgaa ggaaggaagattaaattagtcaacattaactccactgatatagctgatggtcgaccctcc attgttctcggattgatgtggaccattatcctgtatttccagatcgaggagttgaccagc aacctgcctcagctgcaggctctgtccagcagcacgtcctccgtggacagcatggtcagc tctgagaccgccagccccccgagcaaacggaaggtggccaccaagatccaaggaaacgct aagaaggcgctattgaactgggtccagtacatagtcaccaagcagagtggaatagaagta aaagacttcggccggagttggagaagtggagtggcctttcattctgtcatccacgctatt cggccggagctagtggacctggagaaggtgaaaggaaggcctaaccgagaaaacctggag gaggctttcaccattgctgaaacggagctggggatcccacggctcctggaccctgaagat gttgacgtggataaaccagatgagaagtctattatgacctatgtggcccagtttctgaag cagtatcctgacatccacagtacaggctctgatgggcaagagaatgatgaaatacttcca agtttcccatcttttacaaattctatccaaattcttaagagagaagacaggctaattttg aaggagatgaaagtttggatagaacaatttgaaagagatttgacaagggcacagatgaca gactcaagtttgcaggataaatatcagtcatttaagcatttcagagttcaatatgaaatg aagaggaaacagattgaacacttattgcaaccgttacatagagatggtaaattgtcactt gaccaagcattggtaaaacaggcctgggatagagtgtcctccaggctcttcgattggcat atgcaacttgacaagtctcttcctgcacctctgggtaccataggggcctggttatacaga gcagaggtggccctaagagaggaaataaccattcagcaggttcatgaggaaacagccaac acaatacaacggaaacgtgagcaacacaaggatctgcttcaaaacacagatgcccacaaa agagcattccatgaaatctaccggaccaggtctgtgaacgggatcccagtgccgcctgat caattagaggacatggccgagaggtttcattttgtttcctccacatcagagctacactta atgaaaatggaatttctagaattaaagtaccgtctgctctcactgctggttcttgcagag tcaaagctgaagtcttggatcatcaagtatggggggagagattcagtggagctacttctg caaaactacatctcttttatagaaaatagcaagttctttgaacaatatgaagtgacatac cagatcttgaaacagacagctgagatgtatgtcaaagctgatggttcagtggaagaagct gagaatgtgatgaaattcatgaatgaaaccactgcccagtggaggaacctctccgtggaa gtcaggagtgtgcgaagcatgctagaggaagtcatcgccaactgggaccgatacggcaat accgtggctagtcttcaggcttggctcgaggatgctgaaaaaatgctaaatcagtcagaa catgccaaaaaggattttttccgaaatttgcctcattggatacagcagcacacggccatg aatgatgctggcaattttttaatcgaaacgtgtgatgagatggtttcccgtgatctcaaa cagcaattactactgctaaatgggcgatggagggagttgtttatggaagtcaagcaatat gctcgagctgatgagttggacagaatgaagaaagaatacaacgattgtgttactatcttg tctgattttgcaactgaagcccataggaaactttcagagcccttagaagtctcttttatg aatgtcaagttattaattcaagacttggaggatattgaacagagggtgcctgtgatggat gctcagtataagatgataacaaagacagcgcacctcattaccaaagagatctctcaagaa gaagctaatgaaatgtttgcaaccatgtctgggctcaaagagcaactaaccaaggtcaaa gactgttactccccactcctttctgagtctcagcagctgttggtaccgttggaggaatta gaaaagcagatgacggccttttatgactcacttgggaaaatcgatgaaattatgacagtt cttgaacatgaggcacaatctagtcctctttttaaacagaaacatcaggaactgttggct tgtcaagaaagctgtaagaaagccatgactcaaattgagaaaggcagtcagagtgttcag aagtttgtgaccttgagcaacgtgttaaagcattttgaccagacgaagctacagagaaag attgcagatacgcatgttgcttttcagaatatggtaaagaaaactggagattggaagaaa catgtggaaaccaacagccgcttgatgaagaagtttgaggagtctcgagctgagttggag aaggtgctcagggtcgctcaggagggcctggaggaaaagggggacccggaagacctgctg aagagacacaccgagtttttcagtcagctggaccagagggtrctcaatgctttcctgaaa gcgtgtgaygagctcactgacattctgcctgagcaggagcagcggggcctgcaggaagcc gtcagaaagctccacaaacagtggaaggatcttcaagcagaagctccatatcatttgctt cacctgaagattgaggtggagaagaacaggttcttagcttctgtggaagagtgcagagct gagctggaccgagagaccaagctggtgccccaggaaggcagcgaaaaaatcatcaaagag cacaggatcttcttcagtgacaagggccctcaccatctctgtgagaaaaggttacagctc attgaagaactgtgtctgaaacttccagtccgggatgcagtccggaacacacctgagacc tgtcacgtgaccctcaaggagctcagagctgctattgaccgcacctacgtgaagctggtg ggagacccagacaagtggaaggattacacgagcagaatttctgagttctcctcttggata tctgcaaaggagacccagttaaaggggattaagaatgagaccattgatactgctaatcaa ggagaagttaaatgtgctctggaggagatcagaagtggtattaccaaaaaaggggagact ctcagctggctgaaatccaggcttaaaattctgattgaagtttcttctgaggatgaagcc caaaagcaaggagatgagctggcaaaattatctagttctttcaaggctctcgggactttg ttgtcagaggttgaaaagatgttaagcaactttggagactgtgtccagtacaaagaaata gtcaaaagttccctggaagagttaatcactggctctaaasaagtccaggaagaagccgag aagatcttggacactgaaaatttgtttgaagcacaacaactactccttcatcaccagcaa aagacaaagagaatcaatgcaaagaagaaggacgtgcaacaacagatcacgcaggctcag aagggagaaggtgggctgcctgggcgagtccaagaggagctgcagaagctggagagcacc ctggacagtgtggagcacagtcgggagaaacaggagcgccgcatccaggtcacattaaga aaatgggagagatttgaaacaaacaaagagacagtggtcagatacctttttcaaacaggt tccagccatgagcgcttcttgagttttagcagtttggaaagcttatcttcagaattggaa cagacaaaggagttttctaaacgaacagaaggtattgcagtccaggctgagaatcttgtg aaggaagcttcagagatcccacttgggcccaagaataagcagctgcttcagcagcaggcc aagtcaatcaaggagcaagttaaaaaattagaagacacccttgaagaagatattaaaacc atggaaatggtgaaaaacaagtgggatcattttggcactaactttgagaccctgtccgtc tggataactgagaaagaaaaagaactcaatgccttggagacgtcatcatctgccatggat acacaaatcaaccaaattaaggtcatgattaaggaaatagaaagtaagatcagcagcatt 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gttggacgtctaagtctcaaggagcaactctctcaccgacagcatttgctgtctgagatg gagtcactcaagccaaaagtccacgcagtgcaggtccgtcagagtgcgctccggatcccc gaggacgtggtcgccagcctgccgctctgccacgcggctctgcacctgcaggaggaggcc agccggctccagcacacggccatccagcagtgcaacatcatgcaggaggctgtggtgcaa tatgaacaatatgagcaagaaatgcagcacctccaggaactcatagaaggagctcacaga gagattgaggataagcctgtggccaccagcaacatccaggaactgcaagcccagatttct cggcatgaggagctggctcagaaaatcaagggctaccaagagcagatcgcctctttgaac tccaagtgcaagatgctgaccatgaaagccaagcacgccaccatgctgctgacggtgacc gaggtggaggggctggcggaggggacggaggacttggacggggagctcctccccgcgacc tcggcccacccctctgtggtcatgatgactgcaggtcgctgtcacactttgctgtcacct gtcactgaggagtctggggaggagggaaccaacagtgagatctcctctccgcctgcttgc cgctccccttcacctgtggctaatacagatgcctctgttaaccaggacatcgcttattac caagccttatctcctgagaggttacagactgatgctgccaaggttccccccagcacgctg ccaccccaagagctctatgaaccgggactggagccttccgctactgcgaagctggaygat ctgcagcgctcttgggaaaccttaaagaatgtgatcagcgagaagcagcgcacactctat gaagccttggaacgccagcagaagtaccaggactccctccagtccatctccacgaaaatg gaggccatcgagatgaaactcagtgagagtctggagcagggcaggagtcccgagagccag atggccgaacatcaggctctgatggatgagatcctcatgctccaagaggagatcagcgag ctgcagtcggccctcgcagacgagctggtgtctgagtccccggagtccgagccggcagag cagctggccctgcagtccacgctcaccgtcttggcggagcgaatgtccaccatcaagatg aaggcatccgggaagcggcagcttctggaggagaaactcaacgatcagctggaggaacag agacaggaacaagccctgaacaggtatcgctgtgaagctgatcagctggaccactggctc ttgagcacgaaggccactctggacattgccctggggtcacccaaggagcccatggacatg gaggcccagttagtggactgccagaatatgctggtggaaatagagcagaaggtggtggcc ttatcagagctctcggtccacaatgaaaacctgctgctggagggcaaggctcacacaaag gacgaggccgagcagctggcggtgaagctgagaaccctcaaggggagcctcctggagctg cagagggcgctgcaggacaggcaactccacatccaggggacagcccaggagaaggaggag agcgatgctgacctggctgccactcagagccccggggttcaggaatggctggctcaagct cggagcgcatggacccaccagcgacagagcagcctccagcaacaaaaagagttggaacag gaattggcagagcagaagagcctcctccagtcagtagccagccttggagaggaaattcta acgcaacactcagctgcagagacctctggtggtgttggcgaaaaacctgatgtgttatcc caggagttggggatggaaggggagaaatcacctgctgaagaccagatgagaatgaaatgg gaaagcctacatcaagaatttagcaccaagcagaaactacttcagaatgttctggagcag gaacaagagcaaatgctctacagcaggcccaatcggctcctgtctggcgtgccactgtac aaaggcgacgggcaggcccaggataaatctgcggtgacgtctttgctggatggattgaac caggtcttcgaggaggtttcatcccagggtggagggacaaagaagcagaacattgacttg gagcagaagttgtatgatggggtctcggccacctctacctggctggatgatgtagaggaa cggttatttgttgccacagcccttttaccagaagagacagaaacttgcatctttaaccaa gagactcttgccaaagatattaaggaaatgtctgaagaaatggataagaacaagaacttg ttttcccaagcctttccggagaatggtgataaccgagatgttattgaagacactttgggt tgtctcttgggcaggttatctttgctagactcagtagtaaatcagcgatgtcatcagatg aaggaaagacttcagcagatactaaatttccagaatgatctgaaggtgctagttacatca ctggctgaccacaaatacatcattctgcagaagctggcgaaaatgtttgaacaacctgtg gcagagcaaatagaggcaatacagcaggctgaagatgggctaaaggaattagatgcggga atcattgaattaaaaaggcgtgctgacaagttgcagattgagcagccttccatgcaagaa ctctccaaactccaggacatgtatgatgaactcatgatgactattggctcccggcggagy gggctgaaccagaatcttgccctcaagagtcagtacgaaagagccttgcaggatctggcc gacctactggaaacaggacgagagaagacrgcaggagaccagaaaattattgtgtcttcc aaagaggaaatccaacaactacttgataaacataaggaatactttcagggtctggaatct cacatgatcttgaccgaaaccctcttcagaaagatcatcagctttgcagtcccacgggaa actcagttccacacagacctgatggcgcaggcttccgctgtgctcaaaggggctcacaag aggggtgtggarctggagtacatcctcgagacatggtcccaactggagaaggagcactgg gagcttagccggcagctggaggtggtggagagcagcaccccaagcgtgggtttggtggag gagagcgaagacaggcttatcgaccggatcgcactctaccagcatttgaaatccagcctt aatgaataccagcccaaattatatcaggtaatagatgatggaaaacgacttctgatatct gttagctgttcagatctggaaagccagctaaatcaacttggagagcactggttaagtgat accaacaaagtgtctaaggaacttcacagattggaaacaatattgaaacactggaccaga tatcaaagtgaatctgcagatctaatccactggttacagtctgcaaaagacaggctggaa ttttggactcaacaatctgtgacagtcccacaagaactggaaatggtccgtgatcacctg aatggctttctggagttttccaaagaggtggatgccaagtccacgctaaaatcatctgtt ctgagcactggaaatcagcttcttcgattaaagaaagtggacacagctgccttgcgttct gagctgtcccacattgatggccagtggaatgacctgctgacaaatattccagccgtacag gaaaagcttcaccagctccaaatggataaactaccttctcgccacgccatttccgaagtc atgacttggatttctcttatggaaagtgttattcaaaaggatgaagagaatattaaaaat tccatcggttacaagacaattcatgagtaccttcagaaatataagggttttcagatcgac attaactgtaagcagctgactgttgattttgtgaatcagtctgtgctacagatcagcagt caggatgtggaaagtaaacgcagcgacaagactgattttgctgagcgacttggagcaatg aataaaagctggcaaatcctgcagggtctggtcactgagaagattcagttgttggaaggc ttattggaatcttggtcagaatatgaaaataacgtacaatgtctgaaaacgtggtttgaa acccaggaaaagagactgaaacaacaacatcgcattggagaccaggcttcagttcagaac gcaatgaaagactgtcaggatctggaagacttgattaaagcaaaagagaaagaggtagag aaaattgagcagaatggacttgctttggttcagaacaagaaagaagaagtctctggcatt gtcaggagcacgcttcaggagctcaaccaaacttgggcaaatttagaccacatggttggc caactcaagatcctgttgaaatccgtgcttgaccagtggagccaccataaagtggcattt gatgagataaacagttgcctcatggagtcccgatactctctttctcgattctgtctactc actggctctttagaagctgtgcaagttcaggtggacaatcttcagaatcttcaagatgat ctagaaaaacaggaaaagagcttgcagaaatttggctctgtgaccaaccaacttctaaaa gagtgtcacccacctgtgacagaaactcttactaatacactaaaagaagtcaacatgaga tggaataacttgctggaagagattgccgagcagctgcgtgccagcaaggccctacttcag ctttggcagagatacaaggactacttcaaacagtgtgctgctacagttcaacagcaggag ggacgaaccaacgagttcttgaaggcagccaccgacaaggacatcggtgatgacgaagtt gccacctggatccaagattgcaatgacctcctcaaaggattggggccgattcaggattct cttgtagttcttcatgagctgggagggcaactcaagcaacaagtggacgcttcggcagca tcagccattcaatccgattggctctctttgaggcaacaattacatgctctcgaacaggct ctctgcaaacagcagactgtgttacaggctggcgttcttgactatgaaacctttaccaag agtttagaagctttggagacctggatagtagaagctgaagaaatattacaagggcaggac cctagccactcctctgacctctcraccatccaggaaaggatggaggagctgaagggacag atgctgaaattcagtagcatggtcccagatttagaccgtctgaatgagcttggatacagg ctgcccctgaacgataaagaaatcaaaaggatgcagaatctcaatcggcgctggtctctg atctcctcccagactacggaaagattcagtaagttacagtcatttttgctacaacatcag actttcttggaaaaatgtgaaacatggatggaattcctagttcaaacggaacaaaagtta gcagtagagatttcaggcaattatcagcatcttttggagcagcagagagcacatgagttg tttcaagcagagatgttcagccgtcagcagattttgcactcaatcatttttgatggacag caccttctagaacaaggtcaagttgatgacagggatgagttcaacctgaaattgaccctc ctcagtaatcagtggcagggggtgatccgccgggcccagcagaggcggggcgtcattgac agccagatccaccagtggcagcgctacagggagatggcggaaaagctccgtaaatggctg gtggaggtgtcctgtctgcccgtgagtggtctggggactgtccagataccactgcagcag gcaagggccctctttgatcaagtgcagttcaaagaaaaagtgttcctgcggcaacaaggc agctacatcctcaccgtggaggctggcaagcagcttctgctttcggccgacagcggggct gaggccaccctgcaggccsaactcgctgagatccaagagaaatggaagtcagcaagtgtg tgtctggaggagcagaagaaaaaactggccggcttgctgcaggactgggaaaartgtgag aacggaatagctgattctctggagaaactacgaactttcaaaaagaggctttcccagcct ctcccagatcatcaygaagagctccatgcggagcagatgtgctgcaaggaattggaaaac acagttgggagctggacagrtgacttggcacagctgacactgctgaagaaggctctctgt gcttacatcagtgcagatgatatctccatccttaacgaacgcatggagcttctgcagagg cagtgggaagaactatgccaccagctctccttaaggcracagcaagtaagtgagaggctg aacgagtgggccgtcttcagtgaaaagaacaaggagctttgcgaatggctgactcagatg gaaagcaaggtctctcagaatggagacattctcattgaagaaatgattgagaagctcagg aaggattatcaagaggaaattgcaattgcccaagagaacaaaatacagctccagcaaatg ggagaacggctggctcgagccagccatgaaagcaaagcgtctgagattgagtacaagctt ggcaagatcaatgaccggtggcagcaccttctggacctcatggcagccagggtaaagaag ctgaaggagactctggttgcagtacaacagctggataagaacatgagcagtctgaggacg tggttagcccacatcgagtcagagctggccaaacccatygtctacgattcctgtgactca gaagaaatacagaaaaagcttaacgagcagcaggagcttcagagagacatcgagaaacac agcacaggagtggcctctgtgctcaacctgtgcgaggtacttctccatgactgtgatgcc tgcgctacagacgccgagtgcgattccatccagcaggctacgcgaaacctggaccgccga tggagaaacatctgtgccatgtccatggaaaggaggctcaaaattgaagagacatggcga ttgtggcagaagtttctggatgacttttctcattttgaagattggctcaagatctcagaa aggncagctgcctttcccagctcttccggggtgctctatacagttgccaaggaggaacta aagaaatttgaggctttccagcgacaggtccatgagagcctgacccagctggagctgatc aacaagcagtaccgccgcctggccagagagaaccgcacggacgcggccggcagcctcaaa cagacggttcacaaaggcaaccagagatgggacaacctgcagaagcgcgtcacctccatc ctgcgcagactcaagcatttcattggccagcgggaggagttcgagacggcacgggacagc attctggtgtggctgacggagatggatctgcagctcaccaacatcgagcacttctctgag tgtgacgttcaagctaaaataaagcagctcaaggccttccagcaggaaatctcattgaac cacaataagattgaacagataatcgcccaaggagaacagctgatagaaaagagtgagccc ttggatgcggccgtcattgaggaagagctggatgagctccgacgttactgtcaggaggtc tttggacgcgtggaaagataccataagaaactgattcgcctgcctctcccagatgatgag cacgacctctctgaccgggagctggaactggatgaggctggaactctgtcagacctccac tggcgggacacctccacggacggtgtgctctccccgcagccttcctccaacccttccctc tcactcgcccaacccctccggagtgagaggtctggacgagacacccccgccagtgtggac tccatccccctggaatgggaccatgactatgacctcagccgtgacctggagtccgccgtg tccagaactctgccgtctgaggacgaagagggtccggaagataaagatttctacctcagg ggagctgttggcttatcagatgtagtgatccctgaaaatcccgaggcctatgttaaactc acagaaagtgcaatcagaaattcctctggggaccctggtgccttggagtcacagatccga cagctgggcaaagccttggatgacagccgctttcagatgcagcaaacagagaatatcatc cacagcaaaacgcccacaggaccagagctagactccggctacaggggctacatgaaactg ctgggtgaatgcagtggcagcatagactcagtgaaaagactggagcacaagctgaccgag gaagaggaccattttcctggctttgttaacttgaatagcactgaaacccaaacagctggc gtgattgaccgctgggaactcatccaggcagaggccctgagcaaggagctgaggatgaaa cagaagccccagaggaggcagcagttggactcagatctgaatagcgttctgacctggctt agggagacggagggcgacctggaacagcttcagcgcctacagctcagcaccgacatccag tccatcgcgctccaaatccagaagctgaaggagctccagaaagctgtggaccagcgcaaa gccatcatcctgtccatccatctgtgcagctccgagttcactcagcctggccgggaggag agccaggatcttcaggaycgcttgtcccagatgaacgggcggtgggaacgcgtgtgctcc ctgctggaggagtggcggggtcttctccaggatgcgctcatgcagtgccaggattttcat gaaatgagtcayggtttgctgcttatgctggagaacatcgacagaaggaaaaatgaaatt gtccccattgattctaaccttgatgcagaaatacttcaggaccatcacaaacagcttaag caaataagacatgagctgttggaatctcaactcaaagtggcctcactgcaagacatgtct tgccaactgttggtgaatgctgaaggcacagactgtttagaagccaaagaaaaagtccac gtgattggaaatcgactcaaacttctcttgaaggaggtcagtcgtcatatcaaggagctg gagaagttattagacatgtcaagcagtcagcaggatctgtcttcctggtcttctgctgac gaactggacacctcaggatctgtgagtcctacctcgggaagaagtaccccaaacagacag aaaacgccacgaggcaaatgtagtctctcacagcctggaccctctgtcaacagtccacat agcaggtccataagaggtggctccgattcctccctttctgagcctcagccagcccggtcc ggccgagccttcctgttcagagtcctccgagcggctcttcctcttcagctcctcctgctg cttctcattgggctggcctgcctagtccccatgtcagaggaagactacagttgtgccctc tccaacaattttgcccgatcattccaccccatgctcagatacaccaacggccctcctcct ctctga

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