Bos indicus (zebu cattle): 109564326 Help Entry 109564326         CDS       T04792                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism biu  Bos indicus (zebu cattle) Pathway biu04020   Calcium signaling pathway biu04371   Apelin signaling pathway biu04713   Circadian entrainment biu04921   Oxytocin signaling pathway biu04970   Salivary secretion biu05010   Alzheimer disease biu05012   Parkinson disease biu05020   Prion disease biu05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:biu00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     109564326 (RYR3)    04020 Calcium signaling pathway     109564326 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     109564326 (RYR3)   09154 Digestive system    04970 Salivary secretion     109564326 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     109564326 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     109564326 (RYR3)    05012 Parkinson disease     109564326 (RYR3)    05020 Prion disease     109564326 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     109564326 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:biu04040]     109564326 (RYR3) Ion channels [BR:biu04040]  Voltage-gated cation channels   Ryanodine receptor    109564326 (RYR3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RyR RR_TM4-6 RYDR_ITPR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 EF-hand_5 Motif Other DBs NCBI-GeneID:  109564326 NCBI-ProteinID:  XP_019823368 LinkDB All DBs Position 10:complement(28258258..28841092) Genome browser AA seq 4455 aa AA seqDB search MAEGGEGGEDEIQFLRTEDEVVLQCIANVHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVP PDLCVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAILLRHSFSGMYL TCLTTSRSQTDKLAFDVGLREHATGILEVLHCILIESPEALNLIAEGHIKSIISLLDKHG RNHKVLDVLCSLCLCDGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAE GSAQYKKWYFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSY GFDGLHLWSGRIPRAVASINQHLLKSDDVVSCCLDXGAPSISFRINGQPVQGMFENFNTD GLFFPVVSFSAGVKVRFLLGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDAE GIRDLLGTTQFLSQASFIPCPIDTSQVVLPPHLEKIRDRLAENIHELWGMNKIELGWTFG KIRDDNKRQHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEDDLKKVK LPKNYMMSNGYKPAPLDLSDVKLLPPQEVLVDKLAENAHNVWAKDRIKQGWTYGIQQDLK NKRNPRLVPYSLLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADPAVEKVSIDKIR FFRVERSYAVRSGKWYFEFEVVTGGDMRVGWARPGCRPDIELGADDQAFVFEGSRGQRWH QGSGYFGRTWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIDNGFVPICS LGLSQIGRMNLGMDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHP QIEVVRIDGTMDTPPCLKVTHKTFGTQNSSATMIYCRLSVPVECHSSFSHSPCMDSDAFQ KRKQMQEILSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTLG DERGRVHESVKRSNCYMVWGGDIVATSQRASRSNVDLEIGCLVDLAMGMLSFSANGRELG TCYQVEPNTKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFKSEEKNPVPQCPPRLDV QTIQPVLWSRMPSSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDILELCEQE DLMRFHYHTLRLYSALCALGNSRVAYALCSHVDLSQLFYAIDNKYLPGLLRSGFYDLLIS IHLASAKERKLMMKNEYIIPITSTTRKIRLYPDESKRHGLPGVGPRTCLKPGFRFSTPCF ITTNEEHQKQSPEIPLELLKTKALGMLTEAVQCSGAHIRDPVGGSVEFQFVPVLKLIGTL LIMGVFDDDDVRQILLLIDPSVFGEHSGETEEGAEKEEVTQVEEKAVEAGEKASREAPIK GLLQTRLPESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQENQKFRYNELMQAL NMSAALTARKTREFRSPPQEQINMLLNFQLGENCPCPEEIREELYDFHEDLLLHCGVPLE EEEEEEEDSSWTGKFCALVQRIKGPPKPEKEQPTEEEERCPTTLKELISQTMIRWAQEDQ IQDAELVRMMFNLLRRQYDSIGELLQALRKTYTISQASVSDTISLLAALGQIRCLLSVRM GKEEELLMINGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGAEKLQIAFPKMVAS CCRFLCYFCRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELAL GLEEPDLEKVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEE NASVVVKLLIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQGYKREVSTEDD XDEEEIVHMGNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGI ISIPLKLPSLNKDGSVSEPDMAANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPD LRASASLDTVSLSTTEAALALNRYICSAVLPLLTRCAPLFAGTEHYTSLIDSTLQTIYRL SKGRSLTKAQRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLNEYCKMPLKLLTNHYE QCWKYYCLPSGWGSYGLAVEEELHLTEKLFWGIFDSLSHKRYDPDLFRMALPCLSAIAGA LPPDYLDTRISATLEKQVSVDADGNFDPKPINTVNFSLPEKLEYIVTKYAEHSHDRWACD KSQNGWKYGISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEG EALVQQRENEKLRSVSQASQGNSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKK LELESKGGGSHPLLVPYDTLTAKEKFRDREKAQDLFKFLQVNGIVVSRGMKDMELDASSM EKRFAYKFLKKVLKYVDSAQEFIAHLEAIVSSGKNEKSPHDQEIKFFAKVLLPLVDQYFI NHRLYFLSSPLKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGSDSTTMVSCLHIL AQTLDTRTVMKSGSELVKAGLRAFFENAAEDLEKTLENLKLGKFTHSRTQIKGVSQNINY TTVALLPILTSIFEHVAQHQFGVDLLLGDVQLSCYHILCSLYSLGTGKNIYVERQRPALG ECLASLAAAIPVAFLEPTLNRYNPLSVFNTKTPRERSILGMPDTVEEMCPDIPQLEGLMK EINDLAESGARYTEMPHVIEVILPMLCNYLSYWWERGPEHLPPSAGPWCTKVTSEHLSVI LGNILKIINNNLGIDEASWMKRIAVYAQPIIXKARPDLLRSHFIPTLEKLKKKAIKTVQE EEQLRADSKGDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPDADSDQLF RMVAEIFILWCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKSGGQDQERKKTKRRG DFYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYSYKDTDEEVKEHLRNNLHLQ EKSDDPAVKWQLNLYKDVLKSEEPSNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHK LLSKQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKSPK VEEEEEEEVEKQPDPLHQIILHFSRNALTERSKLEDDPLYTSYASMMAKSCQSGEDEDED EDKEKTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILN GGNAGVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLI VRERGEKVLQNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRL QESISDFYWYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLW DAVVGFLHVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVD TLVESSTNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQS EIDFLLSCAEADENDMFNYIDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDP AESVLNYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGG EQEKMELFVNFCEDTIFEMQLASQISESDSADRPDEEEEEGGDSSYVLEVEGEEEEEEKS FECASAFAMACGSVKRNVANFLKRATLKNLRKQYRKVKKMTFKELVKVFFSFFWTLFVGL FHLLFTIVGGIIQVLWSTVFGGGLIEGAKNIRVTKILGDMPDPTQFGIHDDAMEAERAEV PEPGIATELVHFVKGQKGDADIMSDLFGLHPKKEGGLKHGPEVGLGDLSEIIGKDEPPTL ESTVRKKRKAQAAEMKAAHEAERKIESEKADMEDGEKEDTAKEEEQAEALWADVTKRKKR RCGQKVEKPEAFMANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTE EPLEEETEDVANLWNSFNDEEEEEAVVFFVLQESTGYMAPTLRALAIIHTVISLVCVVGY YCLKVPLVVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVK RKVINKYGDLYGAERIAELLGLDKNALDFSPVEETKAEAASLVSWLSSIDMKYHVWKLGV VFTDNSFLYLAWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVG LLAVVVYLYTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIE DPAGDPYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICG IGNDYFDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFF PAGDCFRKQYEDQLG NT seq 13368 nt NT seq  +upstreamnt  +downstreamnt atggccgaagggggagaaggaggcgaggacgagatccagtttctgcggactgaagatgaa gtggtcctccagtgcatcgccaacgttcacaaggagcagaggaagttctgcctggcagcc gagggacttgggaatcgcctgtgcttcttggaacccacttcagaagccaagtatgtkcct ccagatctctgcgtctgcaactttgtgctggaacagtccctctctgtcagagccctgcag gaaatgcttgccaacacaggtgaaaatggcggtgaaggggcagcacaagggggtggccac aggaccctgctgtatggccacgcaattctcctgcggcactccttcagtggcatgtatcta acatgtttgaccacatcaagatcccagacggataaacttgcctttgatgtaggtctacgg gaacatgccacaggtatcttggaagttttgcactgcatcctcattgaaagcccagaagcc ttaaacctgatagcagagggccacatcaagtccatcatctccctgttggataagcaygga cggaatcacaaggttctggatgtgctgtgttccctctgtctctgtgatggggtcgcagtg agagccaaccagaatctcatctgtgacaacttgctgccccggagaaacctgctcctgcag acgcggctgattaatgacgtaacaagtattcggccaaacatcttcctgggagttgctgaa ggctcagcacagtacaagaagtggtacttcgagcttatcatcgaccaggtggaccccttc ctcacagcagagcccacgcatctgcgggtgggctgggcctcttcctctggctacgctcct taccctggaggcggagaaggatgggggggcaatggtgttggtgatgacctatactcctat ggctttgatggacttcacctttggtcaggtcgcatacccagagccgtggcctccatcaac cagcacctcctgaagtcagacgacgtggtaagctgttgcctggacmtgggggcacccagc atctctttccgcatcaacgggcagcctgtgcaggggatgtttgagaacttcaacacagat gggctcttcttccctgtggtgagcttttcagcaggtgtcaaagtccgtttcctgctgggt ggacgtcatggagaatttaagttcctgcctccctctggctatgccccttgctatgaagcc ttacttccaaaagaaaagatgagattggagcctgtcaaagagtataaacgtgatgctgaa ggaattcgagatctgttgggtaccacccagttcctctcccaagcatctttcatcccatgc cccatagataccagtcaggttgttttaccacctcatctagagaaaatacgagacaggctg gctgaaaacatccatgagctttggggaatgaataaaatagagcttggctggacttttggc aagatacgggatgacaataaaagacarcacccctgccttgttgagttttcaaagctgccc gaaactgagaagaattataacctacaaatgtcaactgaaaccttaaaaactctcctggcc ctggggtgccacattgctcatgttaacccagctgctgaggacgatctcaagaaggtcaaa ttgcccaaaaactacatgatgtccaatggctataagccagcccctttggatttgtctgat gtgaagctgttacctcctcaagaagttttagtggataagcttgcagaaaatgcacacaat gtctgggcaaaagacagaataaaacaaggatggacctatggcattcaacaggatttaaag aacaaaagaaatccacgtttggtgccatattcattgctggatgagcgtaccaagaagtca aacmgggacagccttcgtgaagctgtccggacgtttgttggttatggctataacattgag ccatcagaccaagagctagctgacccagctgtggagaaagtcagcatagacaagatccgc tttttccgggtagagcgctcttatgccgtgagatctggaaagtggtatttcgagttcgag gtggtgaccggaggcgacatgcgtgttggctgggcccggccaggctgccgacccgacatt gagctgggggcagatgaccaagccttcgtgtttgaaggcagcaggggccagcgttggcat caagggagtgggtattttggacggacctggcagccaggagatgtggttggatgtatgatt aacctggatgatgcttcaatgatcttcacgctgaatggggagctgctgatcaccaacaaa ggctctgaacttgccttygctgattatgagattgacaatggctttgtgcccatctgctct ctggggctgtctcagatcggccgcatgaatctcgggatggacgccagcaccttcaagttt tataccatgtgcggcctccaagagggctttgagccttttgctgtcaacatgaatcgtgac gtggccatgtggttcagcaaacgcctcccaacatttgtcaacgtgcccaaggatcatccg cagatagaggtcgtgaggatcgacggcaccatggatacccctccgtgcctcaaggtgacc cacaagacattcggcacccagaacagcagtgccaccatgatctactgccgcctgagcgtg cccgtcgagtgccactcctccttcagtcacagcccctgtatggacagtgatgctttccag aaaaggaaacagatgcaagaaatactctctcacacaacaacacagtgctactatgcgatc cgcatctttgccggacaggacccctcctgcgtgtgggtcggatgggtgactccggattat cacttgtacagtgaaaagtttgacctgaataaaaactgtactgtgactgttactctgggg gatgaaagaggccgagtccacgaaagcgtgaaacgcagcaattgctacatggtctggggt ggggacatcgtggctacatcccaaagagcgagtcgcagcaacgtggacctggagattggc tgcctcgtggatctggcgatgggcatgttgtccttttcagccaacgggagggaacttggc acctgctaccaggtggagcccaataccaaagtgtttccagccgtcttcctgcagcccaca agcacctctctgtttcaatttgaacttgggaagctgaagaatgccatgcccctgtcagca gccatatttaagagtgaagagaagaaccccgtccctcaatgcccaccacggctggatgtc caaaccatccagcctgtgctctggagccgcatgcccagcagcttcctgaaggtggagacg gagagggtgagcgagcgccatggctgggtggtgcagtgcctggagcccctgcagatgatg gcactccacatcccggaagagaacaggtgtgtggatatcctggagctctgtgagcaggag gacctcatgcggttccattaccatacactgagactctacagcgccttgtgcgccctggga aatagccgcgtsgcctacgccctgtgcagccatgtggacctctcccaactcttctatgcc attgacaacaagtacctccctggcctcctgcgctcaggcttctatgacctgctcatcagc atccacctggccagcgctaaggagaggaagctgatgatgaagaatgagtacatcatcccc atcaccagcaccaccaggaaaatccgcctgtacccggatgagtccaagaggcacgggctc cctggagtgggcccgagaacgtgcctcaagccagggttcaggttctccaccccctgcttc atcaccaccaacgaggagcaccagaagcagagccccgagattcccttggagcttctcaag acgaaggcactgggcatgctgacggaggcagtgcagtgcagcggtgctcacatccgggac cctgtcgggggttccgtggaattccagtttgtgcctgtgctgaagctcatcggaaccctg ctgatcatgggggtgtttgatgatgatgacgttcggcagatcctcctcctcatcgacccc tctgtgtttggggagcacagtggggagacggaggagggagcagagaaggaggaggtgacr caggtggaggagaaggctgtggaggctggggaaaaggccagcagggaggctcccatcaaa ggcttgttgcagacccgattaccrgagtccgtcaagctgcagatgtgtgagctgctcagc tatctctgtgactgtgagctgcagcaccgggtggaggccattgtggccttcggtgacatc tatgtctccaagctccaggaaaatcagaagttccgctacaacgagctcatgcaggccctg aacatgtctgcggccctgaccgcccggaagaccagggagttccgctcgcccccacaggaa cagatcaacatgcttcttaactttcaactgggggagaactgcccatgcccagaagagatc cgggaagagctgtacgacttccatgaggaccttctccttcactgcggggttcccctggaa gaagaggaagaggaggaagaggattcctcctggactggaaaattctgtgccttggtgcag agaatcaaaggccctcccaagccagagaaggaacaaccaacggaggaagaagagagatgc cctacgaccctgaaggagctcatctcacagaccatgatccgctgggcgcaggaggaccag atccaggatgcagagctggtccggatgatgttcaaccttctgcggcggcagtatgacagc atcggggagctgctgcaggcgctgcgcaagacctataccatcagccaggcctccgtgagc gacaccatcagcctgctagctgccctgggccaaattcgctgcctgctcagcgtcaggatg ggcaaggaggaggagctactcatgatcaacgggctgggagacataatgaacaacaaggta ttttaccagcaccccaacctcatgagagtcctcggcatgcatgagaccgtcatggaggtg atggtgaacgtgctgggtgcagaaaagttgcagattgcctttccaaagatggttgctagc tgttgccgcttcctgtgctatttctgtcgaatcagccgacaaaatcagaaggccatgttt gagcatctaagttacctgttggagaacagcagtgttggcctagcttccccctccatgaga ggatccaccccactggatgtggccgcttcctctgtgatggacaacaatgarttagcgctg ggcttagaggagccagacctcgagaaggtggtgacctacttggcaggctgtggcctacag agctgccccatgcttctagccaaaggataccctgatgtcggctggaaccccattgaaggg gagcgctacctgtccttcctgaggtttgccgtcttcgtgaacagtgaaagtgtggaagaa aatgctagtgtcgtggtcaagctgctcatcagacgccccgagtgcttcggccccgccctg cggggtgaaggaggaaacggtctgttggcrgccatgcaaggcgccattaagatctctgag aacccagccctcgacctcccctcacagggctacaagagggaagtcagcacagaggacgat gawgatgaagaagagatcgtgcacatgggcaatgcaatcatgtcattttattcggctctt atagacctgctgggccgctgtgctcctgagatgcaccttatccagacagggaagggagaa gccatccggatcaggtccatcctgcgctccctggttcccaccgaggacttggttggaatc atcagcatccccttgaaactgccttccctgaacaaagatgggtcggtcagtgagccagat atggcagccaacttctgccctgaccacaaggcgcccatggtactgttcttggaccgtgtg tatggcatcaaggatcaaacttttctgctccacttgctggaagttggatttttacctgac ttaagagcctctgcctctctagatacagtttccctaagcaccaccgaggctgcactggca ctgaacaggtacatatgttctgctgtgctcccactcctcacaagatgcgcccctctcttt gccgggacagagcactacacttctttgattgactctacactgcagacaatatacaggctt tccaaggggcgatccctcaccaaagctcagagggacaccatagaggagtgtttgctggcc atttgcaatcacttgaggccttccatgttacagcaactcctgcgacgtctagtttttgat gtgccccaactcaatgaatactgcaaaatgcctcttaagcttctgacgaatcactaygaa cagtgctggaagtactattgtctgccttcgggctgggggagctacggtctggccgtggag gaagagctacatctgacagagaagctcttctgggggatttttgactccctctctcataag aggtatgacccagatctcttccggatggccctgccctgtctcagtgcaatagcgggggcc ctgccaccagattatttagataccagaatctcagccacattggagaaacaggtctcagtg gacgcagatggcaactttgaccccaaacctatcaacactgtgaatttctccttgcctgaa aaattggaatacattgtcaccaagtatgctgagcactcccatgatagatgggcctgtgac aagagtcagaatggatggaaatacggaatttcgctggatgaaaatgtgaagacccatcca ttgatccggcctttcaagacattaaccgagaaggagaaggaaatttatcgctggcctgcc agagagtccctgaaaaccatgctggctgtaggctggactgtagagaggaccaaagaggga gaagctctggttcaacagcgggaaaatgagaagcttcgaagcgtgtcccaggccagccag ggcaacagctacagccctgcccctctggatctctccaatgtcgtgctctccagagagctc caggggatggtggaggtggtagctgagaactatcacaatatctgggccaagaagaagaag ctggagctggagagcaaaggtggtggcagtcaccctcttttggtaccctatgataccttg actgccaaggaaaagttcagagaccgagagaaggcccaggacctgtttaaattcctccaa gtgaatggcattgtggtttccagaggtatgaaggatatggagctggatgcctcctccatg gaaaagaggtttgcctataagtttttgaagaaggttctgaaatatgttgattcggctcaa gagtttattgcccatttggaagccattgtcagcagtgggaaaaatgaaaagtctccccat gaccaggagatcaaattctttgccaaagttctcctcccactggttgaccagtacttcatc aatcatcgcctgtacttcctgtcctcccctctgaagccccttagcagcagcgggtatgcc tcccataaggagaaagaaatggtggccagcctgttctgcaaactcgctgctctggttcga cacaggatttccctcttcgggagcgattctacgacaatggtgagctgtcttcacatctta gctcagacacttgacacaaggacrgtcatgaagtcaggctcagagctggtgaaagcyggg ttacgggcattctttgaaaatgcagcggaagacttagagaaaactttggaaaacctgaag ctcggcaagtttacccattccagaacacagatcaaaggcgtctctcaaaatattaactac accacggtggctctgctccccatcttgacatccatctttgagcacgtggctcagcatcag ttcggggtggacttacttttgggtgatgtgcagctttcatgctaccatatactgtgcagc ctctactccctygggacaggaaagaacatctatgttgaaaggcagcgtcctgcccttgga gaatgcctggcctcactggcagccgccataccagtggcattcctggagcccacccttaac cgctacaacccgctctccgtcttcaacaccaaaacccccagggagaggtctattctgggg atgccagacacagtggaggagatgtgccccgacatcccccagctggaaggcctgatgaag gaaatcaacgacctggccgagtcaggggcccggtacacagagatgccccacgtcattgag gtcatcttgcccatgctctgcaactacctgtcctactggtgggagcgggggcccgagcac ctgccccccagtgcagggccctggtgcaccaaggtcacgtctgaacacctcagtgtcatc ctgggcaacattctgaaaatcatcaacaacaacctgggcatcgacgaggcctcttggatg aagcgcattgcagtgtacgcccaaccgatcatcrgcaaagccaggccagacctgctgaga agccacttcatcccraccctggagaagctgaagaagaaggccatcaaaactgtgcaggag gaggagcagctgagagctgacagcaagggcgacacgcaggaggcygagctgctcatcctg gacgagtttgctgtcctctgcagagacctctatgccttctaccctatgctcatccgctac gtggacaacaacagatctaactggctcaaaagcccggatgcagactctgaccagctcttc cgcatggtggcagagatcttcatcctgtggtgtaaatctcacaacttcaagagggaagag caaaattttgtgattcagaacgaaattaataatttggcatttttaactggagacagcaaa agcaagatgtcaaaatctggaggacaggaccaggaacggaagaagacaaagcgaagggga gacttttattccatccagacctccctcatcgtggctgcactcaagaaaatgctgcccatt ggtctgaatatgtgcaccccaggcgatcaggagctgatctcccttgcaaaatcacggtac agctataaggacacagatgaagaggtgaaggaacatctgcggaataacttgcacttgcag gaaaagtctgatgatccagctgtaaagtggcaactgaacctatacaaagatgttttaaag agtgaagaaccttccaacccagaaaagacagtggagcgtgtgcagagaatttcagcagct gtcttccacctagagcaggtggaacagcctttgaggtccaagaaggcggtctggcacaaa ctgctatcaaagcagcggaaacgggcagtggtggcctgtttcaggatggcccctctctac aacttgcccaggcaccgctctattaacctcttcctccatggctatcagagattttggata gaaacagaggagtattcctttgaagagaaactagtacaggatttggctaaatctcccaag gtggaagaggaggaggaggaagaggtggaaaagcagccagacccgcttcatcagatcatc ctccactttagccgcaacgctctcacggagaggagcaaactggaagacgaccctttgtac acctcctatgccagcatgatggccaagagctgtcagagtggggaagacgaagatgaggac gaagacaaggagaaaacatttgaagagaaagaaatggaaaagcagaaaaccctctatcag caagcccggctgcatgagcgtggagccgccgagatggtccttcagatgatcagcgccagc aaaggtgagatgagccccatggtggtggaaactctgaagttggggatcgccattctgaat gggggcaatgccggtgtgcagcagaaaatgctagattacctaaaggagaaaaaggatgct gggttctttcaaagtctttctggtcttatgcagtcttgcagtgtccttgatttgaatgca tttgagaggcagaataaagctgaaggcctggggatggttactgaggaaggaacactcatt gttcgtgagcgtggtgaaaaagtactccagaatgacgagtttacacgagatctctttaga ttcctgcagttactttgtgaaggacacaacagtgatttccagaacttcctgaggactcag atgggcaacaccaccacggtgaacgtcatcatcagtaccgtggactaccttctgcgtctg caggaatcaatcagtgatttctactggtattactcagggaaggacatcattgatgaatct ggacagcacaatttttccaaagccctggcggtcaccaagcagatcttcaattctcttaca gaatacatccagggcccctgcattgggaaccagcagagcctggctcacagcaggctgtgg gacgcggtggtcggcttcctccatgtgtttgctaacatgcagatgaaactctcccaggat tccagtcagatcgagctgctgaaggaactcttggatctccttcaggacatggtggtgatg cttctgtccctcctggaagggaatgtggttaatggaaccattggcaagcagatggttgac acactggtagagtcatctaccaatgtagaaatgatcttgaaattctttgacatgttcttg aaacttaaagacttaaccagctcagacaccttcaaagaatatgaccccgatgggaaagga atcatttccaaaaaggaattccagaaggccatggaagggcaaaagcagtacacacagtcg gagatagactttctcctttcatgcgcagaagctgatgaaaatgacatgtttaattacatc gattttgttgaccggttccatgagccagccaaggacatagggtttaatgtggcagtgtta ttgacaaacctctctgagcacatgccaaacgattctcgccttaagtgtctgttggaccca gcagaaagtgtactcaattacttcgaaccatacctgggacgcattgagatcatgggtggg gccaagaaaattgagcgtgtttattttgagatcagcgagtccagtcgaactcagtgggag aagccccaggtgaaggagtctaagcgacagttcatctttgacgttgtcaatgaaggtggg gagcaagagaagatggagctgttcgtgaacttctgtgaggacaccatctttgagatgcag ttagcatcgcagatctcggaatctgactcagctgacaggccagatgaggaggaggaagaa ggtggagattcttcttatgtgttagaagtggagggtgaggaggaggaggaggagaagtcc tttgagtgtgcctctgcatttgccatggcttgtggctcagtgaagagaaacgtggccaac tttctgaagagggccaccctgaagaacctcaggaagcagtacaggaaggtgaagaagatg accttcaaggagctggtgaaggtgttcttctctttcttctggacgttgttcgtggggctc ttccacttgctcttcactatagtgggaggaatcattcaggtcctctggagcacagtgttc ggagggggactcatagaaggggcaaagaacataagagtcaccaagatcctgggtgacatg cctgacccaacccagtttggtatccacgatgatgctatggaagctgagagggcagaagtg cctgagccaggcatcgccacagaactcgtgcacttcgtaaaggggcagaagggagatgca gacatcatgtcagatctctttggactccacccaaagaaagaaggtggcttaaagcatggg cctgaagtgggtttgggtgacctctctgagattattggcaaggacgaaccccctacctta gagagtactgtccggaagaaaaggaaagcacaggcagcagaaatgaaagcagctcatgaa gcagaaagaaaaatagagtctgagaaggcagacatggaagatggggagaaagaggacaca gccaaagaagaagagcaggccgaggccctgtgggcagacgtgaccaaaaggaagaagcga cggtgtggccagaaggttgagaagcctgaagccttcatggccaatttctttaaagggctg gaaatctatcagaccaagctgctgcactacctggccaggaatttctacaacctgaggttc cttgctctgtttgtagccttcgctatcaacttcatcctgctcttttacaaggtcaccgaa gaacctttagaagaagagacagaggatgttgcaaacctrtggaattcctttaatgacgag gaagaggaagaggcrgtggtgttctttgtcctgcaggagagcactgggtacatggcgcca accctgcgggccctggccatcatccacaccgtcatctctttagtctgcgtggtgggctac tactgcctaaaggtccctttggtcgtattcaaaagagaaaaagaaatcgccaggaagctg gagtttgatggcctgtatatcactgaacagccttctgaagatgacatcaaggggcagtgg gatcgcttggtaatcaacacgccatctttccctaataactactgggacaagtttgtaaag agaaaggtgatcaacaaatatggagatctctatggagcagaacgcattgctgaactcctg ggtttggacaaaaatgcccttgactttagcccagtggaagagaccaaagcagaggcggcc tccctggtgtcatggctaagttccatcgacatgaagtaccatgtctggaagctgggagtt gtttttactgacaattcctttctctacctcgcctggtacacgaccatgtcagtcctgggc cactacaacaactttttcttcgcggctcatcttctggatatcgcgatgggcttcaagact ctgaggactattytgtcctctgtcactcacaatggcaaacagttggtcctgaccgttggt ctcctggcygtggtggtttatctctataccgtggtggcattcaacttcttccgcaagttc tacaacaaaagtgaagacgacgacgagcccgacatgaagtgtgatgacatgatgacgtgt tacctgttccacatgtacgtgggagtgagagctggaggtggcattggtgatgaaattgaa gaccctgctggggacccgtatgaaatgtatcgcatcgtttttgacattaccttcttcttc ttcgtcattgtcatcctgctagccatcatccaaggtcttatwattgatgcttttggggag ctgagagaccagcaggaacaagtacgagaggatatggagactaaatgtttcatctgtggg attggcaatgactactttgacacaacgcctcatggttttgaaacacacaccctgcaagag cacaacttagccaactacctgttcttcctcatgtatttgattaacaaagatgagacagag cacacgggacaggaatcttatgtctggaagatgtaccaagaaaggtgctgggatttcttc ccagctggtgactgcttccggaaacaatacgaagatcagcttggataa

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