KEGG   Bos indicus (zebu cattle): 109565053
Entry
109565053         CDS       T04792                                 
Symbol
HERC1
Name
(RefSeq) probable E3 ubiquitin-protein ligase HERC1 isoform X1
  KO
K10594  E3 ubiquitin-protein ligase HERC1 [EC:2.3.2.26]
Organism
biu  Bos indicus (zebu cattle)
Pathway
biu04120  Ubiquitin mediated proteolysis
Brite
KEGG Orthology (KO) [BR:biu00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    109565053 (HERC1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:biu04121]
    109565053 (HERC1)
Enzymes [BR:biu01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.26  HECT-type E3 ubiquitin transferase
     109565053 (HERC1)
Ubiquitin system [BR:biu04121]
 Ubiquitin ligases (E3)
  HECT type E3
   109565053 (HERC1)
SSDB
Motif
Pfam: RCC1 RCC1_2 HECT WD40_CDC20-Fz SPRY WD40 WD40_WDHD1_1st WD40_Prp19 Beta-prop_EML_2 Beta-prop_CAF1B_HIR1 Beta-prop_IFT140_1st Beta-prop_WDR35_TULP_N Beta-prop_TEP1_2nd Beta-prop_RIG_2nd EIF3I WDR55 Beta-prop_WDR75_1st Beta-prop_EML WD40_MABP1-WDR62_2nd CLASP_N
Other DBs
NCBI-GeneID: 109565053
NCBI-ProteinID: XP_019824260
UniProt: A0A6P5CEE2
LinkDB
Position
10:46526687..46739035
AA seq 4895 aa
MATMVPPVKLKWLEHLNSSWITEDSESIATREGVAVLYSKLVSNKEVVPLPQQVLCLKGP
QLPDFERESLSSDEQDHYLDALLSSQLALAKMVCSDSPFAGALRKRLLVLQRVFYALSNK
YHDKGKVKQQQHSPESSSGSADVHSVSERPRSSTDALIEMGVRTGLSLLFALLRQSWMMP
VSGPGLSLCNDVIHTAIEVVSSLPPLSLANESKIPPMGLDCLSQVTTFLKGVTIPNSGAD
TLGRRLASELLLGLAAQRGSLRYLLEWIEMALGASAVVNSMEKSKLLSSQEGMISFDCFM
TILMQMRRSLGSSADRSQWREPTRTSDGLCSLYEAALCLFEEVCRMASDYSRTCASPDSI
QTGDTPIVSETCEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTIEAGQYCTFVIST
DGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVF
SWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDF
GRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTN
RVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCGSSEATALRPKLIE
ELAATRIVDISIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAI
QQISAGTSHSLAWTALPRDRQVVAWHRPYCVDLEESTFSHLRSFLERYCDKINSEIPPLP
FPSSREHHNFLKLCLKLLSNHLALALAGGVATSILGRQAGPLRNLLFRLMDSTVPDEIQE
VVIETLSVGATMLLPPLRERMELLHSLLPQGPDRWESLSKGQRMQLDIILTSLQDHTHVA
SLLGYSSPSDAADLSSVCTGYGNLSDQPYGTQSCHPDTHLAEILMKTLLRNLGFYTDQAF
GELEKNSDKFLLGTSSSENSQPAHLHELLCSLQKQLLAFCHINNISENSSSVALLHKHLQ
LLLPHATDIYSRSANLLKESPWNGSVGEKLRDVIYVSAAGSMLCQIVNSLLLLPVSVARP
LLSYLLDLLPPLDCLNRLLPAAALLEDQELQWPLHGGPELIDPAGMPLPQPAQSWVWLVD
LERTIALLIGRCLGGMLQGSPVSPEEQDTAYWMKTPLFSDGVEMDTPQLDKCMSCLLEVA
LSGNEEQKPFDYKLRPEIAVFVDLALGCSKEPARSLWISMQDYAISKDWDSATLSNESLL
DTVSRFVLAALLKHTNLLSQACGESRYQPGKSLSEVYRCVYKVRSRLLACKNLELIQTRS
SSRDRWISENQDSADVDPQEHSFTRTIDEEAEMEEQAERDREEGHPEPEDEEEEREHEVM
TAGKIFQCFLSAREVARSRDRDRMNSGAGSGARADDPPPQAQQERRVSTDLPEGQDVYTA
ACNSVIHRCALLILGVSPVIEELQKRREEGQLQQPSTSTSEGGGLMTRSESLTAESRLVH
ASPNYRLIKSRSESDLSQPESDEEGYALSGRRNVDLDLASSHRKRVYLLLFGQLSPRKKK
SFKQVHDGPMHSQLESLSDSWTRLKHNRDWLCSSSYSFESDFDLTKSLGVHTLIENVVSF
VSGDVGNAPGFKEPEESMSTSPQASIIAMEQQQLRAELRLEALHQILVLLSGMEEKGSIS
LTGSRLSSGFQSSTLLTSVRLQFLAGCFGLGTVGHAGAKGESGRLHHYQDGIRAAKRNIQ
IEIQVAVHKIYQQLSATLERALQANKHHIEAQQRLLLVTVFALSVHYQPVDVSLAISTGL
LNVLSQLCGTDTMLGQPLQLLPKTGVSQLSTALKVASTRLLQILAITTGTYADKLSPKVV
QSLLDLLCSQLKNLLSQAGVLLMASFGEGEEDEEGKKIDSSGETEKRDFRAALRKQHAAE
LHLGDFLVFLRRVVSSKAIQSKMASPKWTEVLLNIASQKCSSGIPLVGNLRTRLLALHVL
EAVLPACESGVEDDQMAQVVERLFSLLSDCMWETPIAQAKHAIQIKEKEQEIKLQKQGEL
EEEDENLPIQEVSFDPEKAQCCIVENGQILTHGSGGKGYGLASTGVTSGCYQWKFYIVKE
NRGNEGTCVGVSRWPVHDFNHRTTSDMWLYRAYSGNLYHNGEQTLTLSSFTQGDFITCVL
DMEARTISFGKNGEEPKLAFEDVDAAELYPCVMFYSSNPGEKVKICDMQMRGTPRDLLPG
DPICSPVAAVLAEATIQLIRILHRTDRWTYCINKKMMERLHKIKICIKESGQKLKKSRSV
QSREENEMREEKENKEEEKGKHSRHGLADLSEPQLRTLCLEVWPVLAVIGGVDAGLRVGG
RCVHKQTGRHATLLGVVKEGSTSAKVQWDEAEITISFPTFWSPSDTPLYNLEPCEPLPFD
VARFRGLTASVLLDLTYLTGIHEDMGKQSTKRHEKKHRHESEEKGDVEQKIESESALDTR
TGLTSDDVKGTTSSKSENEIASFSLDSAVPGVESQHQITEGKRKNHEHMSKNHDIAQSEI
RAVQLSYLYLGAMKSLSALLGCSKYAELLLIPKVLAENGHNSDCASSPVVHEDVEMRAAL
QFLMRHMVKRAVMRSPIKRALGLADLERAQAMIYKLVVHGLLEDQFGGKIKQEIDQQAEE
SDQAQQAQTPVTTSPSASSTTSFMSSSLEDTTTATTPVTDTETVPASESPGVMPLSLLRQ
MFSSYPTTTVLPTRRAQTPPISSLPTSPSDEVGRRQSLTSPDSQSARPTNRTALSDPSSR
LSTSPPPPAIAVPLLEMGFSLRQIAKAMEATGARGEADAQNITVLAMWMIEHPGHEDEEE
PQSGSTADSRHGAAVAGSGGKSNDPCYLQSPGDIPSADAAEMEEGFSESADNLDHAENAA
SGSGPPARGRSAVTRRHKFDLAARTLLARAAGLYRSVQAHRNQSRREGISLQQDPGALYD
FNLDEELEIDLDDEAMEAMFGQDLTSDNDILGMWIPEVLDWPTWHVCESEDREEVVVCEL
CECSVVNFNQHMKRNHPGCGRSANRQGYRSNGSYVDGWFGGECGSGNPYYLLCGSCREKY
LALKTKSKATSSERYKGQAPDLIGKQDSVYEEDWDMLDVDEDEKLTGEEEFELLAGPLGL
NDRRIVPEPVQFPDSDPLGASVAMVTATNSMEETLMQIGCHGSVEKSSSGRITLGEQAAA
LANPHDRVVALRRVTAAAQVLLARTMVMRALSLLSVSGSSCSLAAGLESLGLTDIRTLVR
LMCLAAAGRAGLSTSPSAVASASERSRGGHSKANKPISCLAYLSTAVGCLASNTPSAAKL
LVQLCTQNLISAATGVNLTTVDDPIQRKFLPSFLRGIAEENKLVTSPNFVVTQALVALLA
DKGAKLRPNYDKSEVEKKGLTAQLYAHPPCDPSAAGPLELANALAACCLSSRLSSQHRQW
AAQQLVRTLAAHDRDNQTAPQTLADMGGDLRKCSFIKLEAHQNRVMTCVWCNKKGLLATS
GNDGTIRVWNVTKKQYSLQQTCVFNRLEGDAEESLGSPSDPSFSPVSWSISGKYLAGALE
KMVNIWQVNGGKGLVDIQPHWVSALAWPEEGPSTAWSGESPELLLVGRMDGSLGLIEVVD
VSTMHRRELEHCYRKDVSVTCIAWFSEDRPFAVGYFDGKLLLGTKEPLEKGGIVLIDAHK
DTLTSMKWDPTGHILMTCAKEENVKLWGPISGCWRCLHSLCHPSIVNGIAWCSLPGKGSK
LHLLMATGCQSGLVCVWRIPQDTTQTSVTSSEGWWDQESSCQDGYRKSVGAKCVYQLRGH
ITPVRTVAFSSDGLALVSGGLGGLMNIWSLRDGSVLQTVVIGSGAIQTTVWIPDVGVAAC
SNRSKDVLVVNCTAEWTAANHVLATCRTALKQQGILGLNMAPCMRAFLERLPMMLQEQYA
YEKPHVVCGDQLVHSPYMQCLASLAVGLHLDQLLCNPPVPPHHQHCLPDPASWNPNEWAW
LECFSTTIKAAEALTNGAQFPESFTVPDLEPVPEDELVLLMDNSKWINGMDEQIMSWATS
RPEDWHLGGKCDVYLWGAGRHGQLAEAGRNVMVPAAAPSFSQAQQVICGQNCTFVIQANG
TVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSW
GDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRL
GLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTA
KSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIP
VLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQGKNVR
QISAGRCHSAAWTAPPVPPRAPGVSVPLQLGLPDTVPPQYGALREVSIHTARARLRLLYH
FSDLMYSSWRLLNLSPNNQNSTSHYNAGTWGIVQGQLRPLLAPRVYTLPMVRSIGKTMVQ
GKNYGPQITVKRISTRGRKCKPIFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADDAGG
VFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFLFNPSACLDEHLMQFKFLGILM
GVAIRTKKPLDLHLAPLVWKQLCCVPLTLEDLEEVDLLYVQTLNSILHIEDSGITEESFH
EMIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEMDRQVAAVREGM
SWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYREVDEQHQLVQWFWHTLEEFSN
EERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVM
AERLRYAINNCRSIDMDNYMLSRNVDNAEGSDTDY
NT seq 14688 nt   +upstreamnt  +downstreamnt
atggcaactatggttccaccagtgaaactgaaatggcttgaacacctcaacagctcctgg
attacagaggacagtgaatctattgctacaagagagggggttgctgttttatattctaaa
ctggtcagcaataaggaagtagtacctttgcctcaacaagttttgtgcctcaaaggacca
cagctgccagactttgaacgtgagtctctttcaagcgatgaacaggaccactatttggat
gcccttcttagcagtcagctagcacttgcaaagatggtatgttcagattccccatttgct
ggggcacttcgaaaacgattgcttgtactccagcgtgtcttctatgcactttctaataaa
taccacgacaaaggcaaagtgaaacagcagcagcattctccggagagcagctctggttca
gcagatgtccattctgttagtgaacgtcctcggtcaagcactgatgcacttatagaaatg
ggtgttcgaactggtctaagtttattatttgcacttctgagacaaagttggatgatgcct
gtgtcgggacctggtctcagtctttgcaatgatgttattcatactgcaattgaagttgtg
agctctttgccaccattatctttagcaaatgaaagcaagattccacctatgggcttggat
tgcttatcacaagtaacaacctttcttaaaggagtaactattcccaattctggagcagac
actttaggtcgtagattagcttctgagttgctgcttggtttagcagctcagcgaggttct
ttgcggtatctccttgaatggatagaaatggcactgggggcttcagcagttgtaaattcc
atggagaaaagcaaactactgtcaagccaagaaggaatgatcagctttgactgctttatg
actatattaatgcagatgaggcgttctttgggttcatctgctgatcggagtcagtggagg
gaaccaaccagaacatctgatggcttgtgctcactctatgaggcagctttgtgtctcttt
gaagaggtttgcagaatggcttctgattactcaagaacatgtgctagccctgatagcatt
cagactggtgatactcccattgtttcagaaacctgtgaggtttatgtttgggggagcaat
agcagccatcagttggtagaaggcacacaggagaaaatactacaacccaaactggctcct
agtttctctgatgctcagactattgaagctggacagtactgcacttttgtcatttctaca
gatggctctgtcagagcttgtggtaaaggcagctatggaagactaggccttggcgactct
aataatcaatctactttaaaaaagttaacatttgaacctcacaggtccattaaaaaggtc
tcatcttctaaaggatctgatggtcatactttagctttcactacagaaggagaagtcttc
agctggggagatggtgattatgggaaactgggacatggaaatagttcaacacagaaatat
cccaagcttattcagggccctctgcagggaaaggtagttgtctgtgtgtcagctggatac
agacatagtgctgctgtcacagaggatggtgaattatacacatggggtgaaggagatttt
ggaagattaggtcatggtgacagtaatagtcgtaacatcccaacattagtaaaagacatt
agcaatgtaggagaagtttcttgtggcagttcacatactattgctttatctaaagatggg
agaactgtatggtcttttggaggaggagacaatggcaaacttggccatggtgataccaac
agagtgtataaacctaaagttattgaagctttacaaggaatgttcattcgtaaagtttgt
gctggaagtcagtcttcacttgctttgacatcaacagggcaggtctatgcttggggctgt
ggagcttgtctaggttgtggttcatcagaagctactgcactgagaccaaagcttattgaa
gaactggctgccacaagaatagttgatatttctattggagacagtcattgtttggctctt
tctcatgataatgaagtttatgcctggggaaataactcaatggggcagtgtggacaagga
aactccacaggtcctattactaaaccaaagaaagtaagtggcttagatggcatagctatt
caacagatctctgctggaacatcacatagtctagcatggactgctcttcctagggacaga
caagttgttgcctggcaccgaccttattgtgtagatcttgaagagagtaccttctcacac
cttcgttcatttcttgagagatattgtgataaaataaacagtgagattcccccactccct
ttcccttcatcaagggaacaccacaatttcctcaaactgtgcctgaagctgctttcaaat
caccttgctcttgcacttgcgggaggggtagctactagcatccttgggagacaggcaggt
ccgcttcgaaatttgctcttcagactgatggactcaactgtcccagatgaaatccaagag
gttgtaattgaaactctgtcagtgggagcaaccatgctgttacctcctttacgagaacgt
atggaattacttcattctcttttaccccaaggacctgatagatgggaaagcttatctaaa
ggacagagaatgcaactggatattattctgacaagtttgcaagatcatacccatgtagcc
tccttacttgggtatagctcaccctctgatgctgctgacctctcttccgtatgtactggc
tatggaaacctgtcagatcaaccttatggcactcagagctgccatccagacactcatctg
gctgaaattttgatgaagactctcttaagaaatttaggattttatacagatcaagcattt
ggggagctagaaaagaacagtgataaatttctacttggaacatcgtcttcagagaacagt
cagcccgctcatcttcatgaactgctatgttcactgcagaaacagctgctggcattttgc
catatcaataacataagtgaaaactcaagcagtgtggcattgcttcataaacatcttcag
ctcttgttgcctcatgccacggatatttattcacgttctgcaaatttgctgaaagaaagt
ccttggaatggcagtgttggagaaaaattaagagatgtgatatacgtctcagctgcaggc
agtatgctctgccagattgttaactccctcctgttactcccagtgtcggtggctcggcct
ttgttgagttacctcctcgacttgttgccacctcttgattgccttaatagactcctgcca
gctgctgctcttttggaagaccaagagttacagtggcctcttcatggaggrccagaactg
atcgaccctgctggcatgccactacctcagccagcccagtcctgggtgtggcttgtggat
ctggaaagaacaattgctcttcttattgggcgatgtcttggtggcatgcttcagggttcg
cctgtgtctccagaggaacaggacactgcatattggatgaaaacaccactttttagtgat
ggtgtagaaatggacacccctcagttagataaatgtatgagttgcctattagaagtagct
ctttcgggaaatgaggaacagaagccttttgattataaattgcggcctgaaattgctgtc
tttgtagacttggccttgggttgttcaaaagagcctgctcgaagcctttggatcagcatg
caggattatgctattagtaaagattgggacagtgcaactttgagtaatgagtcactcttg
gacactgtgtctagatttgttcttgcagctcttctgaaacacacaaatttactcagtcaa
gcatgtggagaaagccgatatcaacctggtaaaagcttatcagaagtataccgttgtgtg
tacaaagttcgaagtcgtttacttgcttgcaagaaccttgaacttattcagaccaggtca
tcgtcaagagacagatggatctcggaaaaccaagactcygcagatgttgatcctcaggag
cattcatttacccggaccattgatgaagaagctgaaatggaagaacaggctgagcgagat
cgggaagaaggacatccagagccagaggatgaggaggaagaacgagaacacgaagtgatg
acagctggcaaaatctttcagtgtttcctctcagcccgtgaagtagctcgtagccgagat
cgagatagaatgaacagtggggcagggtctggggctcgagctgatgatccacctcctcag
gctcagcaagagcgaagggtgagcacagaccttcctgagggtcaggatgtgtacactgct
gcctgcaactccgtgatccatcgatgtgccctgttaatattaggagtaagtcctgtgatt
gaggagcttcagaagcgaagggaagaaggacagttgcagcagccttccacaagtacctct
gaagggggtggacttatgaccaggagtgaaagtcttactgcagagagccggctagtccac
gcaagtccaaattatagactgatcaaatcgaggagtgaatctgatttgtctcagcctgaa
tcagatgaagagggttacgcactgagtggaagacgaaaygttgatttggatttggcatca
tctcatagaaagagagtgtatttactcctttttggccagttgagccccagaaaaaagaag
agcttcaagcaagtacatgatggtcctatgcacagtcaattggaatctctgagtgactcg
tggactcgcctgaaacataacagagactggttgtgcagttcctcttattcctttgagtct
gattttgatcttaccaagtctttgggagttcacactttgattgaaaatgttgtaagcttt
gtgagtggagatgtggggaatgccccaggttttaaagagccagaggaaagtatgtctaca
agtccccaggcctccatcattgcaatggagcagcaacagttaagggcagaactccgttta
gaggcacttcatcagatacttgttctgttgtctggaatggaagaaaaaggtagcatctct
ctgacaggaagcagattgagctcaggtttccagtcatccactctgctcacatctgtgagg
ctgcagtttctagcagggtgtttcggtttaggcactgttggacatgcaggagccaaagga
gagagtggccgattgcatcactatcaggatgggatcagagcagctaagagaaatattcag
attgaaatccaggtggctgtgcataagatttatcaacagttgtctgctaccttggagaga
gccctgcaagccaacaarcaccacattgaagcccaacagcgtctccttttggttacagtt
tttgccctgagtgttcactatcagccagtagatgtttctttggcgatttccactggtctg
ctaaatgtattgtcacagttatgtggcacagacaccatgctaggacagcctcttcagttg
ttgccaaaaacaggtgtttcccagcttagcacagctttaaaagtggctagtacaaggctg
ctccagattctagccatcactacagggacctatgctgataaactgagccccaaggtagtt
caatctttgttggatctactttgtagtcagttgaagaatttgttgtcccaggctggtgta
ttgcttatggcctcttttggagaaggagaagaggatgaagaaggaaaaaaaattgactct
agtggagaaactgagaagagagatttcagagctgctcttaggaaacagcacgcagctgaa
ctgcatctgggggatttcctagtttttcttcgcagagttgtatcttcaaaagcaattcaa
tcaaaaatggcttccccaaagtggacagaagtgcttttaaatatagcatctcagaaatgt
tcttcaggaattcctctagttggtaacttaagaacgaggctccttgcacttcaygtcctt
gaggctgtgctgccagcttgtgaatctggtgtagaagatgatcagatggcccaggttgtg
gaacgcctgttttccctcctgtcagattgtatgtgggagacacccattgctcaggccaaa
catgctattcagataaaggaaaaagaacaagaaataaaattacagaagcagggagagttg
gaggaagaagatgagaatcttcctatacaagaagtatcctttgacccagagaaagctcag
tgttgcatagtggaaaatggacagattttaactcatggcagtggaggaaaaggatatgga
ctggcgtcaactggagtaacttctgggtgctatcagtggaagttttacattgtgaaggaa
aacagaggtaatgaaggcacgtgtgttggagtttctcgttggccagtacacgactttaac
caccgtactacctcggatatgtggctctatcgggcctacagtggtaacctctatcacaac
ggagaacagactctgacgttatccagctttactcaaggagatttcattacctgtgtgtta
gacatggaagccaggaccatttcctttgggaagaatggagaggaacccaaattagctttt
gaagatgtggatgcagcagagttgtacccatgcgtaatgttctatagtagcaacccaggg
gaaaaggtgaaaatttgtgatatgcagatgcgtggcacaccacgagacctccttccagga
gatcctatttgtagtccagtagctgcagtgctggcagaggccactattcagcttattcgt
atccttcatcgaacagaccgttggacttactgcattaacaaaaaaatgatggaaaggcta
cacaaaattaagatatgtattaaagaatcaggtcagaagctaaagaaaagccgctcggtt
caaagccgagaggaaaatgaaatgagagaagaaaaggaaaacaaagaggaagagaaaggt
aaacacagtaggcatggccttgctgacctgtcagaaccgcagctgaggaccctttgccta
gaggtgtggcctgtgctggcagtgataggaggagttgatgctggtcttagagttggaggt
cggtgtgttcacaagcaaactgggcgccatgccacgctgctgggagtggtcaaagagggc
agcacgtctgccaaagtccaatgggatgaagcagaaattaccatcagcttcccaactttt
tggtcgcctagtgatactccattgtataatctggaaccctgtgaaccacttccttttgac
gtggcacgatttcgaggcctgacagcttctgtgttgctggacctcacatatctgactggc
attcatgaagacatgggcaaacagagcacgaagcgacatgaaaagaaacaccgacatgaa
tctgaggagaaaggggatgttgaacagaaaattgagagtgaatctgctttggacacacga
acrggcttaacatctgatgatgttaagggtaccacaagctccaaatcagaaaacgaaata
gcttcattttctttagattcagcagtgccaggtgtggaatcccaacatcagataacagaa
ggaaaaagaaaaaatcatgaacacatgtccaaaaaccatgacatagcccagtcagaaatc
agagcagtccagctgtcctatctctacctcggtgctatgaagtcactcagtgctcttctt
ggctgtagtaaatatgctgaactgttgctgataccaaaagttctggctgaaaatggccac
aactcagactgtgcaagctctccagttgttcatgaagacgtggagatgcgtgcagccctt
cagtttttgatgcgccacatggtgaagcgagcggtcatgcggtcacccataaagagagca
ctgggattagcagatctggaacgagctcaagccatgatctataaattagtggtccatggg
cttttggaagaccaatttgggggcaaaattaagcaagagattgatcaacaagctgaggaa
agtgaccaagcccaacaggcacagaccccagttaccaccagcccatcagcctcaagtaca
acttcctttatgagcagctcactggaggacaccacaactgccacgactccagtcactgac
acagaaacggtgcctgcgtctgagtccccaggggtgatgccccttagtcttctcaggcaa
atgttctctagttacccaactaccactgtgcttcccacgcgtcgtgcacagactcctcca
atatcatcgttaccaacctctccttctgatgaagtaggaagaaggcagagcttaacttct
cctgattcccagtcagcaaggccaaccaaccgcacagccttgtcagacccaagcagtaga
ctttcaacttctcctcctcctccagcgattgcagtacccttgttagaaatggggttctct
ctccggcagattgcraaagccatggaagccacaggtgctcgaggcgaggctgatgcccag
aacatcaccgtccttgccatgtggatgatagagcaccctgggcatgaggatgaggaagag
ccccagtcaggcagcacagcagactcaaggcacggagcagcagttgcaggcagtggtggg
aagtcaaatgatccctgttatttgcagtcaccaggagacataccgtcagctgatgctgct
gaaatggaggaaggctttagtgaaagtgctgataatctggatcatgcagagaatgcagct
tctggaagtggaccgccggctaggggtcgctcagcagtaacaagaaggcacaagtttgat
ttagctgctcgaacattgctagcaagagcagcggggttataccgctctgtgcaggcccac
aggaatcaaagtcggagagaaggaatatctttgcaacaagacccaggggcgttgtatgac
tttaatttagatgaggaattggaaattgatcttgatgatgaagcgatggaagctatgttt
ggacaagacctgaccagtgacaatgatattctgggaatgtggatcccagaggtactggat
tggcctacctggcatgtttgtgagtctgaagacagggaagaagtggtggtgtgtgagctg
tgtgaatgcagtgtcgtcaacttcaatcagcacatgaagagaaatcacccaggctgcggg
cggagcgcaaaccgccagggctatcgcagcaacggctcctatgtggatggctggttcggt
ggtgaatgtgggagtggaaatccatactacctgctatgtggcagctgcagggaaaagtac
ttagccctgaagaccaaatccaaggcaacaagttctgaaaggtacaaaggacaagctcca
gatcttattggcaagcaggacagtgtgtatgaagaagactgggacatgttggatgttgat
gaagatgaaaagctaacaggtgaagaagagtttgaattacttgctggccctcttggttta
aacgaccgccgcattgtaccagaaccagttcagttccctgacagtgatccattaggagca
tcagtagcaatggtaacagcaaccaacagtatggaagagactctgatgcaaataggttgc
catggctctgtagaaaagagttcctctgggagaataacattgggtgaacaggcagctgcc
ttagcaaatcctcatgaccgggtggttgctttaaggagagtgacggctgctgctcaggtt
cttctggccagaaccatggtcatgagagctctgtctcttctctcagtcagtggttccagt
tgtagcctggctgctggtctcgaatctctggggcttaccgatatccggactttggttcga
ctcatgtgcttggctgcagcagggagagcgggcctctccaccagtccttctgccgtggca
agcgcttcagaacgctcacgaggcgggcacagcaaggccaacaagcccatttcctgcctg
gcctatctgagcacagcagtgggatgtctagcatcaaacactcctagtgctgcaaagctc
ctggtgcagttatgtacacagaacttgatttctgctgccacaggtgtaaatctaaccaca
gttgacgatccaattcagcgaaagtttctacctagctttctccgaggaattgctgaagag
aataagcttgtaacctccccaaattttgttgtaactcaggctcttgtggcattactagca
gacaaaggggccaaattgagacctaattatgataagtcagaagttgaaaagaaaggttta
actgcccaattgtatgcccatcctccctgtgacccttctgctgcaggccctctggagctg
gctaacgccctggcagcctgctgcctctcctcgaggctgtcctcgcagcacaggcagtgg
gctgctcagcagctcgtgcgcactcttgccgcacatgaccgcgacaaccagactgctcca
cagacgcttgctgatatgggaggagatctcagaaaatgctcctttatcaagttggaggcg
catcagaacagagtaatgacttgtgtttggtgtaataaaaaaggactgttggctacaagt
ggcaatgatggcaccatccgggtttggaatgtcaccaagaagcagtattcactgcaacag
acctgtgtgttcaacagattggaaggtgatgctgaggaaagcctaggatcacccagtgat
ccaagtttctcacctgtttcctggagtatcagtggcaaatacctagctggggctttggaa
aagatggtgaatatctggcaagttaatggaggaaaagggttagtagatattcagcctcat
tgggtatctgctctggcttggccagaagagggtccatctacagcctggtcaggagagtct
ccagaattgttgttggtgggacggatggatggatctctaggactgattgaagttgttgat
gtatccaccatgcaccgtcgagaactggagcattgctatcgaaaggatgtgtctgtaact
tgcattgcttggttcagtgaagacagaccatttgcagtgggatattttgatggaaaattg
ttactgggaacaaaggaaccacttgagaaaggaggcattgttctaattgatgcacataag
gatactcttactagtatgaagtgggacccaacaggtcatattcttatgacatgtgccaaa
gaagaaaatgtgaaactctggggaccaatttcagggtgctggcgctgtctacattcactc
tgccatccatctattgtaaatggcattgcttggtgcagccttccaggaaaaggatccaag
ttgcatttactgatggccactggctgtcagagtggcttagtatgtgtttggcgtattccc
caagataccacacagaccagtgtgactagttcagaaggatggtgggaccaggaatcaagt
tgccaggatggatataggaaatcagttggagccaagtgtgtttatcagttgcgaggacac
atcacccctgtacggaccgttgcctttagttctgatgggttggccctggtgtctggtgga
ttaggtggccttatgaacatttggtctttaagggatggctctgtcttgcaaactgttgtg
attggctctggagctattcagaccacagtatggattccagatgttggggtggctgcttgc
tcaaatagatcaaaggatgttttggtcgtgaattgtacagcagaatggactgctgccaat
catgttttagcaacctgtaggacagcactgaaacaacaaggtattctgggattaaacatg
gctccctgcatgagagcatttctggagcggctacccatgatgcttcaggagcagtatgca
tatgaaaagcctcatgtggtttgtggagaccagcttgttcacagcccctatatgcagtgt
ctggcttcccttgctgtgggacttcatctggatcagctgctgtgtaatccgccagtgccc
ccacaccaccagcactgcctccctgaccctgcatcctggaatccaaatgagtgggcctgg
ttagagtgcttttccaccaccataaaagctgctgaagccctgacaaatggagcacagttt
ccagaatcttttactgttccagatctagagcctgttccagaggatgaacttgtactccta
atggataatagtaaatggatcaatggcatggatgaacaaattatgtcttgggcaacttcc
agacctgaggactggcacctgggaggtaaatgtgatgtctacttgtggggtgctggcagg
catggacagctggcagaagctggaagaaatgtgatggtacctgcagcagctccctcattc
tcacaggcccaacaggtcatatgtggtcaaaattgtacctttgtcatccaggccaatggc
acagtgttggcttgtggggaaggaagttatggcagattaggacaaggaaattcagatgac
cttcatgtgctgacagtcatttcagccttacaaggctttgtggtgacccagctggtgact
tcctgtggttctgatgggcactcaatggccctgactgaaagtggtgaggtctttagctgg
ggagatggtgattatggcaaactcggccatgggaacagcgacaggcagcgacggcccagg
cagatcgaggccttacagggagaagaagtggtgcagatgtcttgtggcttcaaacactca
gcagtggtaacatcagatggcaaactgtttacctttgggaatggtgactatggtcgtctg
ggtctgggaaacacctctaacaaaaaacttccagagagagtgactgcactggagggatat
cagattggacaggtggcttgtggcttaaaccacacattggcggtgtcagcagatggctcc
atggtgtgggcttttggagatggggactatggaaaactaggtttaggaaattccactgca
aaatcttcacctcagaaagttgatgtcctttgtggaattggaataaaaaaggttgcttgt
ggaactcagttttctgttgcattaaccaaagatggtcatgtgtataccttyggtcaagat
cgcttgataggcttgccagaagggcgtgctcgcaatcacaatcgaccacagcaaatccct
gtcctggctggagtggtcatcgaagatgtggctgttggagctgaacacacacttgcattg
gcatcaactggagatgtgtatgcctgggggagcaattcagaaggtcagcttggcttaggt
cataccaaccacgttcgagaaccaaccctggtaacagttctgcaagggaaaaatgttcgg
cagatctcagctggccgctgccacagtgctgcatggacagcgcckcctgtcccgccaaga
gcaccaggtgtgtcagtgcctctgcagctgggcctgcccgatacagtgcccccccagtac
ggggctctgagggaggtgagcattcacactgcgagggccaggctccggctgctttaccat
ttctctgacctcatgtactcatcctggaggctgctgaacctcagccccaacaaccagaat
agtacgtctcattataatgctggaacatggggcattgtgcagggacagcttcggcctttg
ttagccccaagagtctacaccctcccaatggtgcgctctataggaaaaaccatggttcaa
ggcaaaaactatggacctcaaattactgtaaagaggatatcaaccagaggacggaaatgt
aagcctatctttgttcaaatagcgagacaagtagttaaactgaatgcctcagacctccgt
ctgccttcccgagcttggaaggttaagctagttggagaaggtgctgatgacgccggagga
gtgtttgatgacacaatcacagagatgtgccaggaacttgaaactggtattgtggacctt
cttataccctctcccaatgctaccgcagaagtgggttacaatagggacaggttccttttt
aatccttctgcctgccttgatgaacacttaatgcagtttaagttcttaggaatcttaatg
ggggttgccattcgcacaaagaagcctctggacctccacttggcccctctggtgtggaag
cagctctgctgtgttccactcaccctggaagacctggaagaggtggatctgctctacgtg
cagactctcaacagcattcttcacattgaagacagtgggattactgaggagagtttccat
gagatgattcctcttgattcttttgttggccaaagcgctgatggcaaaatggttcctata
atccctggtggaaatagtatcccactcacgttttctaataggaaagaatatgtggagagg
gccattgaatatcgacttcatgaaatggaccgacaggtggctgcagtccgagaaggaatg
tcctggatcgtccctgtgccgctgttgtccctcctcacagcaaagcagctggagcagatg
gtgtgtgggatgcctgagatctccgtagaagtcttgaagaaagtggtacggtaccgggag
gtggatgagcagcatcagctggtgcagtggttctggcacacactggaggagttctccaac
gaggagcgtgtgcttttcatgaggtttgtgtctggaagatctcgactaccagccaacact
gctgatatttctcagagatttcaaatcatgaaggttgataggccttacgacagtctgcct
acctcacagacctgcttcttccagctgagactgcccccctactctagccagctggtcatg
gctgagcgcctgcgctacgccatcaacaactgccgatcaatcgacatggacaactacatg
ctctcgcgaaacgtggacaacgctgagggctccgacactgactactga

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