KEGG   Bos indicus (zebu cattle): 109573971
Entry
109573971         CDS       T04792                                 
Symbol
ERBB2
Name
(RefSeq) LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-2
  KO
K05083  receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
Organism
biu  Bos indicus (zebu cattle)
Pathway
biu01521  EGFR tyrosine kinase inhibitor resistance
biu01522  Endocrine resistance
biu01524  Platinum drug resistance
biu04010  MAPK signaling pathway
biu04012  ErbB signaling pathway
biu04020  Calcium signaling pathway
biu04066  HIF-1 signaling pathway
biu04151  PI3K-Akt signaling pathway
biu04510  Focal adhesion
biu04520  Adherens junction
biu04530  Tight junction
biu05200  Pathways in cancer
biu05205  Proteoglycans in cancer
biu05206  MicroRNAs in cancer
biu05212  Pancreatic cancer
biu05213  Endometrial cancer
biu05215  Prostate cancer
biu05219  Bladder cancer
biu05223  Non-small cell lung cancer
biu05224  Breast cancer
biu05226  Gastric cancer
biu05230  Central carbon metabolism in cancer
Brite
KEGG Orthology (KO) [BR:biu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    109573971 (ERBB2)
   04012 ErbB signaling pathway
    109573971 (ERBB2)
   04066 HIF-1 signaling pathway
    109573971 (ERBB2)
   04020 Calcium signaling pathway
    109573971 (ERBB2)
   04151 PI3K-Akt signaling pathway
    109573971 (ERBB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    109573971 (ERBB2)
   04520 Adherens junction
    109573971 (ERBB2)
   04530 Tight junction
    109573971 (ERBB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    109573971 (ERBB2)
   05206 MicroRNAs in cancer
    109573971 (ERBB2)
   05205 Proteoglycans in cancer
    109573971 (ERBB2)
   05230 Central carbon metabolism in cancer
    109573971 (ERBB2)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    109573971 (ERBB2)
   05226 Gastric cancer
    109573971 (ERBB2)
   05219 Bladder cancer
    109573971 (ERBB2)
   05215 Prostate cancer
    109573971 (ERBB2)
   05213 Endometrial cancer
    109573971 (ERBB2)
   05224 Breast cancer
    109573971 (ERBB2)
   05223 Non-small cell lung cancer
    109573971 (ERBB2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    109573971 (ERBB2)
   01524 Platinum drug resistance
    109573971 (ERBB2)
   01522 Endocrine resistance
    109573971 (ERBB2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:biu01001]
    109573971 (ERBB2)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:biu04147]
    109573971 (ERBB2)
   04090 CD molecules [BR:biu04090]
    109573971 (ERBB2)
Enzymes [BR:biu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     109573971 (ERBB2)
Protein kinases [BR:biu01001]
 Receptor tyrosine kinases (RTK)
  EGFR family [OT]
   109573971 (ERBB2)
Exosome [BR:biu04147]
 Exosomal proteins
  Exosomal proteins of breast cancer cells
   109573971 (ERBB2)
CD molecules [BR:biu04090]
 Proteins
  109573971 (ERBB2)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Recep_L_domain GF_recep_IV Pkinase Furin-like TM_ErbB1 ABC1 Haspin_kinase APH Kinase-like CcmD
Other DBs
NCBI-GeneID: 109573971
NCBI-ProteinID: XP_019837162
UniProt: A0A6P5DIY1
LinkDB
Position
19:41331372..41362898
AA seq 1255 aa
MELAAWCRWGLLLALLPPGAAGTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNL
ELTYLPADASLSFLQEIQEVQGYVLIAHNRVSQVPLQRLRIVRGTQLFEEHYALAVLDNG
DFLESAAPAAGTAPGGLQELQLRSLTEILKGGVLIQRNPQLCHQDTILWEDIFHKNNQLP
LKQIDTNRSRACAPCSPACKAPNCWGESSQDCQSLTRTVCASGCARCKGPQPTDCCHEQC
AAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLNNQEVTAEDGTQRCEKCSKPCAPVCYGLGMEHLREVRAVTSAN
IQEFAGCKKIFGSLAFLPESFAGDPDSNIAPLQAEQLKVFESLEEITGYLYISAWPDSLP
DLSVFQNLRVIRGRVLHDGAYSLTLQGLGISWLGLRSLRELGSGLALIHRNARLCFVHTV
PWDQLFQNPHQALLHSANRPEDECVGEGLACYPLCAQGHCWGPGPTQCVNCSQFLRGQEC
VEECRVLQGLPREYVKDRYCLPCHPECHPQNGSVTCFGSEADQCVACAHYKDPPFCVARC
PSGVKPDLSFMPIWKFPDEEGICQPCPINCTHSCVDLDDKGCPAEQRASPVTSIIAAVVG
VLLVVLVGLVFGILIKRRRQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETEL
RKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSP
YVSRLLGICLTSTVQLVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEDVR
LVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFT
HQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWM
IDSECRPRFRELVAEFSRMARDPQRFVVIQNEDMGPASPLDSTFYRSLLEDDDMGDLVDA
EEYLVPQQGFFCPDPAPGAAGTAHRRHRSTSTRSGGGELTLGLEPSEEEPPRSPLAPSEG
AGSDVFDGDLGMGAAKGLQPLPQHDSSPLQRYSEDPTVPLSPEADGYVAPLTCSPQPEYV
NQPEVHPQPPSPLEGPLPPPRPAGSTLERPKTLSPGKNGVVKDVFAFGAAVENPEYLAPR
GRAAPQSHPSPAFSPAFDNLYYWDQDPSERGTPPSTFEGTPTAENPEYLGLDMPV
NT seq 3768 nt   +upstreamnt  +downstreamnt
atggagctggcggcctggtgccgctgggggctcctcctcgccctcctgccccccggagcc
gcgggcacccaagtgtgcaccggcacagacatgaagctgcggctgccggccagtcccgag
acccacctggacatgctgcgccacctctaccaaggctgtcaggtggtgcagggtaacctg
gagctcacctatctgcctgctgatgccagcctctccttcctgcaggaaatccaggaggtg
cagggctatgtgctcatcgctcacaatcgagtgagtcaggtcccactgcagagactgcga
atcgtgcgaggcacccagctttttgaggaacactacgccctggccgtgctggacaatgga
gactttctggaaagtgctgcccctgctgcaggcacagccccaggagggctgcaggagctg
cagctgcgaagcctcacagagatcctcaagggaggggtcttgatccagcggaacccccag
ctctgccaccaggacacgattttgtgggaggatatcttccacaagaacaaccagctgccc
ctcaagcagatagacaccaaccgctcacgggcctgcgcaccctgttctccagcttgtaaa
gctcccaactgctggggagaaagttctcaggactgtcagagcttgacgcggaccgtctgt
gccagtggctgtgcccgctgtaagggcccacagcccaccgactgctgccatgagcagtgc
gctgctggctgtactggccccaagcactctgactgcctggcctgcctccacttcaaccac
agcggcatctgcgagctgcactgcccagctctggtcacctacaacacagacaccttcgag
tccatgcccaaccccgaggggcgttataccttcggtgccagctgtgtgacggcctgtcct
tacaactacctgtctacggatgtgggatcctgcaccctggtttgtcccctgaacaaccaa
gaggtgacagctgaggatggaacccagaggtgtgagaaatgcagcaagccctgtgcccca
gtgtgctatggtctgggcatggaacacctgcgggaggtgagggcggtcaccagtgccaac
atccaggagtttgccggctgcaagaagatttttgggagcctggcgtttctgccagagagc
tttgcaggggacccagactctaacatcgccccgctgcaggctgagcagctcaaagtgttt
gagtctctggaggagatcacaggttacctgtacatctcagcgtggccagacagcctgcct
gacctcagcgtcttccagaacctgcgagtaatccggggacgagttctgcatgatggtgcc
tactcgctgaccctgcaagggctgggcatcagctggctggggctgcgctcgctgcgggaa
ctgggcagcgggctggccctcattcaccgcaacgcccgcctctgcttcgtacacacggtg
ccctgggaccagctcttccagaacccccaccaggctctgctccacagcgccaacaggcca
gaggatgagtgcgtgggcgagggcctggcctgctacccactgtgcgcccaagggcactgc
tggggtcccgggcccacccagtgcgtcaactgcagccagttccttcggggccaggaatgc
gtggaggaatgccgagtactgcaggggctcccccgggagtacgtgaaggacaggtactgt
ctgccgtgccaccccgagtgtcatccccagaatggctcagtgacctgctttggctcggag
gctgaccaatgtgtggcttgtgcccactacaaggatcctcccttctgcgtggctcgctgc
cccagtggtgtgaagcctgacctctccttcatgcccatctggaagtttccagatgaggag
ggcatatgccagccatgccccatcaactgcacccactcctgtgtggacttggatgacaag
ggctgccccgccgagcagagagccagccctgtgacatccatcattgccgctgtggtgggc
gttctgctggttgtycttgtggggctggtgttcggcatcctcattaagcgaaggcggcag
aagatccggaagtacacgatgcggaggctgctgcaggagacggagctggtggagccyctg
acgcccagcggagcgatgcccaatcaggctcagatgcggatcttaaaagagacagagctg
aggaaggtgaaggtgctaggatctggagcttttggcaccgtctacaagggcatctggatc
cctgatggggaaaatgtgaaaatccccgtggccatcaaggtgttgagggaaaacacatct
cccaaagccaacaaggaaatcttggacgaagcatatgtgatggctggtgtaggctcccca
tatgtgtcccgcctcctgggcatctgcctgacatccacagtgcagctggtgacacagctg
atgccctatggctgcctcctagaccacgttcgagaacaccgtgggcgcctgggctcycag
gacctgctgaactggtgtgtgcagattgccaaggggatgagctacttggaggatgtgcgg
ctcgtgcacagggacctggccgcccggaacgtgctggtcaagagtcccaaccatgtgaag
attacagacttcgggctggctcggctgytagacattgacgagacagartaccacgcggat
gggggcaaggtgcccatcaagtggatggcattggagtccattctccggcggcggtttacc
caccagagtgacgtgtggagctatggtgtgactgtgtgggagctgatgacttttggggcc
aaaccttatgatgggatcccagcccgggagattcctgacctgctggagaagggagaacgg
ctgccccagccccccatctgcaccattgatgtctacatgatcatggtcaaatgttggatg
attgactctgaatgtcggccgaggttccgggagttagtggctgaattctcccgcatggcc
agggacccccagcgctttgtggtcatccagaatgaagacatggggcctgctagccccctg
gatagcaccttctaccgctcgctgctggaggatgacgacatgggygacctggtggatgcg
gaggagtacctggtaccccagcagggcttcttctgcccagaccctgccccgggtgctgca
ggcacggcccatcgcaggcaccgcagcacatccaccaggagtggcggtggtgagctgaca
ctggggctggagccctctgaggaggagcctcccagatctccgctggcaccttccgaaggg
gcaggctctgatgtgtttgatggtgacttgggaatgggggcggccaagggactgcagccc
ctcccccaacatgactctagtcctctgcagcggtacagcgaggaccccacagtacccctt
tctcccgaggctgatggctacgttgcccccttgacctgcagcccccagccggaatatgtg
aaccagccagaggttcacccacagcccccctcacccctagagggtcctctgccgcctcct
cgacctgctggttccactctggaaaggcccaagacgctatcccctgggaagaatggggtt
gtcaaagacgtttttgcctttggggctgccgtggagaaccctgagtacttggcaccccgg
ggcagggctgcccctcagtcccacccttctccagccttcagcccagcctttgacaacctc
tattattgggaccaggacccatcagagcggggcactccacccagcacctttgaagggacc
cctacggcagagaaccctgagtacttgggtctggacatgccagtatga

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