Bos indicus (zebu cattle): 109575441
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Entry
109575441 CDS
T04792
Symbol
PDE8A
Name
(RefSeq) high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
KO
K18437
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 [EC:
3.1.4.53
]
Organism
biu
Bos indicus (zebu cattle)
Pathway
biu00230
Purine metabolism
biu01100
Metabolic pathways
biu04927
Cortisol synthesis and secretion
biu04934
Cushing syndrome
biu05032
Morphine addiction
Brite
KEGG Orthology (KO) [BR:
biu00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
109575441 (PDE8A)
09150 Organismal Systems
09152 Endocrine system
04927 Cortisol synthesis and secretion
109575441 (PDE8A)
09160 Human Diseases
09165 Substance dependence
05032 Morphine addiction
109575441 (PDE8A)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
109575441 (PDE8A)
Enzymes [BR:
biu01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.53 3',5'-cyclic-AMP phosphodiesterase
109575441 (PDE8A)
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Gene cluster
GFIT
Motif
Pfam:
PDEase_I
PDE8A_N
PAS_9
PAS
PDE8
PAS_3
PAS_4
DUF5894
SPO22
PAS_8
Motif
Other DBs
NCBI-GeneID:
109575441
NCBI-ProteinID:
XP_019839127
UniProt:
A0A6P5DQ07
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Position
21:22398686..22541711
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AA seq
832 aa
AA seq
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MGCAPSIHISESRGVYPGGKEAEDVPGPAAAPLPPGGPSLPPGQKTAASTRAPGSSLAES
EPRGGNGSKVAIADVQFGPMRFHPDQLQVLLVFTKEDNQCNGFCRACEKAGFMCTVTKEA
QTALACFLDKHHDIIIIDHRNSRHLDAEALCRSIRSSKLSENTVIIGVVRRVEREESCVM
SLIAAGFTRRYIENPSPMACYNELLQLEFGEVRSQLKLRACNSMFAALEKSQEAIEITSE
DHIIQYANPAFETTMGYQSGELIGKEIAEVPINEKKADLLDTINSCKEWQGIYSVRKKNG
DNVQQNVKIIPVIGQGGKIRHYVSIIRVCNGNNKAETIAECVQTDSYADNQSGKHKDRRK
SSLDVKTVASRTNEVSSQRRHSSMARIHSMTIEAPITKVINIINAAQESSPMPVTEALDR
VLEILRTTELYSPQFGAKDDDPHANDLVGGLVSDGLRRLSGNEYVLSTKNLQQAPSSSIV
PISLHDVPSQITRAMEKEEYWDFSIFELEAATHKRPLIYLGLKVFARFGVCEFLKCPEAT
LRSWLQVIEANYHASNPYHNSTHSADVLHATAYFLCKERIKQTLDPLDEVAALIAATIHD
VDHPGRTNSFLCNAGSELAILYNDMAVLEHHHAALAFQLTTGDDKCNIFKNMERNDYQTL
RQGIIDMVLATEMTKHFEHVNKFVNIINKPLVALEEEEETDKDQEAINTMLRAPENRTLI
KRMLIKCADVSNPCRPLEQCIEWAARISEEYFSQTDEEKQRDLPVVMPVFDRNTCSIPKS
QISFIDYFITDMFDAWDAFVDLPELMQHLDNNFKYWKGLDDMKLRSLRPPPE
NT seq
2499 nt
NT seq
+upstream
nt +downstream
nt
atgggctgcgccccgagcatccacatttccgagagccgtggggtgtaccccggcggcaag
gaggccgaggacgtgccgggccccgcggcggcgccgctcccgcccggcgggccgagcctc
ccacccggccagaagacggccgcctcgacccgggcccccggctccagcctcgcagagtcc
gagcctcgcggaggcaacggcagcaaggtagcaatagctgatgtgcaatttggccccatg
agatttcatccagatcaactccaggtacttttagtgtttaccaaagaagataaccagtgt
aatggattctgcagggcgtgtgaaaaagcagggtttatgtgtacagttaccaaggaggct
cagactgccctcgcctgtttcttggacaaacaccatgacatcatcatcatagatcacaga
aattcccgacatctggatgctgaggcactgtgcaggtcaatcagatcatcaaaactctca
gaaaacacagttattattggtgtagtacgcagagtggagagagaggagtcgtgtgtaatg
tccctcattgctgctggcttcacaaggaggtatatagaaaaccccagccccatggcctgt
tacaatgaactgctccagctggagtttggagaggtgcgctcacagctgaaactcagggct
tgtaattcaatgttcgctgcattagagaaaagtcaagaagcaattgaaattacaagtgaa
gaccacattatccagtatgcaaatccagcgttcgaaacgacaatgggctatcagtcaggt
gaattaatagggaaggagatagcagaagtgcctataaacgaaaaaaaggctgatttgctt
gatactataaattcatgcaaggaatggcaaggaatttactctgtcaggaagaaaaatgga
gataacgtacaacaaaatgtgaagataatacctgtcattggacagggaggaaaaattaga
cactatgtgtccattatcagagtgtgcaatggcaacaataaggcggagacgatagctgaa
tgtgttcagacggacagttacgcagataatcagtcaggcaaacataaagacaggagaaaa
agctccctcgatgtcaaaactgttgcctctcgaacaaatgaagtttccagccagagacga
cactcttccatggcccggatccattccatgacgatcgaggcgcccatcaccaaggtcatc
aatatcatcaatgctgcccaggaaagcagtcccatgcctgtgacagaagctttagaccgt
gtgttggaaattctaagaaccactgaattatattcaccacagttcggtgctaaggacgat
gatcctcacgccaatgacctcgtcgggggcctggtgtctgatggtttgcgaagattatcc
ggaaatgagtatgttctttcaacaaaaaaccttcagcaggctcccagcagcagcattgtc
cccatctcccttcatgatgttccatcacagataactcgggccatggaaaaggaggagtac
tgggacttcagtatttttgaactggaggctgccactcataaaaggcctttgatttacctt
ggtctcaaagtgtttgctcgsttcggagtctgtgaattcttaaaatgccccgaggcaacg
ctgagatcctggttacaggtgatcgaagccaattatcacgcttccaacccctaccacaac
tccacacactctgctgatgtgctgcatgccactgcctactttctctgcaaagagaggatc
aagcaaactttagacccacttgatgaggttgctgccctcatcgcagccactatccacgat
gtggaccacccygggaggactaactccttcctgtgcaatgccgggagcgagctggccatt
ctctacaacgacatggctgtgctggagcaccaccacgcggccttggccttccagctgacc
accggcgatgacaaatgcaacatctttaaaaacatggagcggaacgactaccagacgctg
cgccagggtatcattgacatggtcttagccacagaaatgacaaagcactttgagcacgtc
aacaaatttgtcaacatcatcaacaagcccttggtagcattagaagaagaagaggaaact
gataaagatcaagaagccataaataccatgctcagggctccagagaaccggactctgatc
aaaaggatgctgatcaagtgtgctgacgtgtccaacccctgccggcccctggagcagtgc
atcgagtgggctgcgcgcatctcagaagagtatttctctcagacagacgaagagaagcaa
cgggacttgcctgtggtgatgccggtttttgacagaaatacctgcagcatccccaaatcc
cagatctctttcatcgactacttcatcacagacatgtttgatgcctgggatgcctttgta
gacctgcctgagttaatgcagcatctcgacaacaactttaaatactggaaaggactggac
gacatgaagctgcggagcctgcgcccgcctcccgaatag
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