Bos indicus (zebu cattle): 109577226
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Entry
109577226 CDS
T04792
Symbol
GCLC
Name
(RefSeq) glutamate--cysteine ligase catalytic subunit isoform X1
KO
K11204
glutamate--cysteine ligase catalytic subunit [EC:
6.3.2.2
]
Organism
biu
Bos indicus (zebu cattle)
Pathway
biu00270
Cysteine and methionine metabolism
biu00480
Glutathione metabolism
biu01100
Metabolic pathways
biu01240
Biosynthesis of cofactors
biu04216
Ferroptosis
Module
biu_M00118
Glutathione biosynthesis, glutamate => glutathione
Brite
KEGG Orthology (KO) [BR:
biu00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
109577226 (GCLC)
09106 Metabolism of other amino acids
00480 Glutathione metabolism
109577226 (GCLC)
09140 Cellular Processes
09143 Cell growth and death
04216 Ferroptosis
109577226 (GCLC)
Enzymes [BR:
biu01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.2 glutamate---cysteine ligase
109577226 (GCLC)
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GFIT
Motif
Pfam:
GCS
GCS2
SANT_DAMP1_like
Motif
Other DBs
NCBI-GeneID:
109577226
NCBI-ProteinID:
XP_019841623
UniProt:
A0A6P5DTA9
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Position
23:7202826..7246972
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AA seq
638 aa
AA seq
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MGLLSQGSPLSWEETQRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDH
EKKKAQLVLSGEELLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTV
EDNMRKRRKEATSLLGENQALCTITSFPRLGCPGFTLPEFKPNPVEGGASKSLFFPDEAI
NKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPAPFIETFPEDEEATKASKPDHIYMDA
MGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVI
SASVDDRTREERGLEPLKNNHYRISKSRYDSIDSYLSECGEKYNDIDLTKDKEIYEQLLQ
EGLDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDI
GWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVL
QELFYFRKDICKAGGNAVVDGCGKAAGRAEPAAEEYALMTIDTIINGKEGVFPGLIPVLN
SYLESMEVDVDTRCSILNYLKLIKKRASGELMTVAKWMREFIAKHPDYKQDSVITDQMNY
SLLLKCNQIANESCECPELLGPAFRKVRYSGSKTDSST
NT seq
1917 nt
NT seq
+upstream
nt +downstream
nt
atggggctgctgtcccagggctcgccgctgagctgggaggagacccagcgccacgccgac
cacgtgcggcggcacgggatcctccagttcctgcacatctaccacgccgtcaaggaccgg
cacaaggacgtgctcaagtggggcgatgaggtggagtacatgttggtgtcttttgatcat
gaaaagaaaaaagcccaactggtcctgtctggagaggaacttcttgaaactctgcaagaa
aagggggaaaggacgaacccaaaccatccaaccctttggagaccagaatatgggagctac
atgatcgaggggacacccgggcagccgtacggtgggaccatgtctgaattcaacacagtt
gaggacaacatgaggaaacggcgcaaagaagccacatctctcctgggggaaaaccaggcc
ctctgcacgatcacttcctttcccagattaggctgccctgggttcacgctgcccgagttc
aaacccaacccggtggaaggaggagcttccaagtcccttttctttcctgatgaagccatc
aacaagcacccgcgcttcagcacgctcaccaggaacatccggcaccggaggggcgagaaa
gtggtcatcaacgtgcccatctttaaggacaagaacaccccagctccatttatagagact
ttccctgaggacgaggaggccacgaaggcctctaagcccgaccacatttacatggacgcc
atgggcttcgggatgggcaactgctgcctacaggtaacgttccaagcctgcagcatatct
gaggccagatacctttacgatcagttggctaccatytgcccaattgtcatggctttgagt
gctgcgtcgcctttttaccgaggctacgtgtcagacattgattgtcgctggggcgtgatt
tccgcgtctgtagatgatagaactcgggaggagagaggactggagccactgaagaacaac
cactataggatcagtaagtcccgatacgattcgatagacagttacttgtctgagtgtggt
gagaaatacaatgacattgacctgacaaaagacaaagaaatctacgaacagctgttgcag
gaaggcctcgaccacctgctggcccagcacgtggcgcatctcttcatcagagacccgctg
actctgtttgaagagaaaatccacctggatgatgccaacgagtccgaccactttgagaat
attcagtccacaaattggcagacaatgcgattcaagcctcctcctccaaactctgacatt
gggtggagagtggaattccggcccatggaggttcagctgacagacttcgagaactccgcg
tatgtggtgttcgtggtgctgctcaccagggtgatcctgtcctacaaactggactttctc
atcccgctgtccaaggttgatgagaacatgaaggtcgcccagaagcgagatgccgtcctg
caggaactgttttatttcaggaaagacatttgcaaagcaggtggcaacgccgtggtggac
ggctgcggcaaggccgcgggcagggcggagccagcggcggaggagtacgcgctcatgacc
atcgacaccatcatcaacggcaaggaaggcgtgttccccgggctgatccccgtcctgaac
tcctacctggagagcatggaggtggacgtggacaccaggtgcagcattctgaactacctg
aagctcatcaagaagagggcgtccggagaattaatgacagttgccaaatggatgagggag
tttatcgcaaagcatcccgactacaagcaggacagtgtaataactgaccagatgaactat
agccttcttctaaagtgtaatcaaatcgcaaacgaatcgtgtgagtgcccagagttactc
ggaccagcgtttaggaaagtcaggtacagtggaagtaaaaccgactcttccacttag
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