Bos javanicus (banteng): 133240343 Help Entry 133240343         CDS       T11659                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism bjv  Bos javanicus (banteng) Pathway bjv04020   Calcium signaling pathway bjv04024   cAMP signaling pathway bjv04260   Cardiac muscle contraction bjv04261   Adrenergic signaling in cardiomyocytes bjv04371   Apelin signaling pathway bjv04713   Circadian entrainment bjv04911   Insulin secretion bjv04921   Oxytocin signaling pathway bjv04972   Pancreatic secretion bjv05020   Prion disease bjv05022   Pathways of neurodegeneration - multiple diseases bjv05410   Hypertrophic cardiomyopathy bjv05412   Arrhythmogenic right ventricular cardiomyopathy bjv05414   Dilated cardiomyopathy bjv05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:bjv00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     133240343 (RYR2)    04020 Calcium signaling pathway     133240343 (RYR2)    04024 cAMP signaling pathway     133240343 (RYR2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     133240343 (RYR2)    04921 Oxytocin signaling pathway     133240343 (RYR2)   09153 Circulatory system    04260 Cardiac muscle contraction     133240343 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     133240343 (RYR2)   09154 Digestive system    04972 Pancreatic secretion     133240343 (RYR2)   09159 Environmental adaptation    04713 Circadian entrainment     133240343 (RYR2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     133240343 (RYR2)    05022 Pathways of neurodegeneration - multiple diseases     133240343 (RYR2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     133240343 (RYR2)    05412 Arrhythmogenic right ventricular cardiomyopathy     133240343 (RYR2)    05414 Dilated cardiomyopathy     133240343 (RYR2)    05415 Diabetic cardiomyopathy     133240343 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:bjv04040]     133240343 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:bjv04990]     133240343 (RYR2) Ion channels [BR:bjv04040]  Voltage-gated cation channels   Ryanodine receptor    133240343 (RYR2) Domain-containing proteins not elsewhere classified [BR:bjv04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    133240343 (RYR2) SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  133240343 NCBI-ProteinID:  XP_061260919 LinkDB All DBs Position 28:11147112..11977845 Genome browser AA seq 4874 aa AA seqDB search MQTAQGGGHRTLLYGHAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWI IHPASKQRSEGEKVRVGDDLILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGS EAAQGYLIGGDVLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLR VAWSGSHIRWGQPFRLRHVTTGKYLSLMEDKSLLLMDKEKADVKSTAFTFRSSKEKLDVG VRKEVDGMGTSEIKYGDSVCYIQHINTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDD GLNLSRSQHEESRTARVIRSTVFLFNRFIRGLDALSKKVKASTVDLPIESVSLSLQDLIG YFHPPDEHLEHEDKQNRLRALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGRE AGESWKSILNSLYELLAALIRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVE SPEALNIIKEGHIKSIISLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRD LLLQTRLVNHVSSMRPNIFLGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTE GYSPYPGGGEEWGGNGVGDDLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDL SAPSISFRINGQPVQGMFENFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAP CYEAVLPKEKLKVEHSREYKQERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERI REKLAENIHELWVMNKIELGWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLK TLLALGCHVGISDEHAEEKVKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAE NAHNVWARDRIRQGWTYGIQQDVKNRRNPRLVPYALLDDRTKKSNKDSLREAVRTLLGYG YNLEAPDQDHAARAEVCSGTGERFRIFRAEKTYAVKAGRWYFEFEAVTAGDMRVGWSRPG CQPDQELGSDERAFAFDGFKAQRWHQGNEHYGRSWQAGDVVGCMVDMTEHTMMFTLNGEI LLDDSGSELAFKDFDVGDGFIPVCSLGVAQVGRLNFGKDVSTLKYFTICGLQEGYEPFAV NTNRDITMWLSKRLPQFLQVPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSSTDIMF YRLSMPIECAEVFSKTAAGGIPGTGLFGPKNDLEDYDVDSDFEVLMKTAHGHLVPDRGDR DKEATKPEFNNHKDYAQEKPSRLKQRFLLRRTKPDYSTSHSARLTEDVLADERDDYDYLM QTSTYYYSVRIFPGQEPANVWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIK RSNCYMVCAGESLSPGQGRNNNGLEIGCVVDAASGLLTFTANGKELSTYYQVEPSTKLFP AVFAQATSPNVFQFELGRIKNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPN QFLKVDVSRISERQGWLVQCVEPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRLY SAVCALGNHRVAHALCSHVDEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMM NNEFIVPMTEETKSITLFPDEKKKHGLPGIGLSTSLRPRMQFSSPSFVSINTEGYQYSPE FPLDILKAKTIQMLTEAVKEGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGVFHNEDLKH VLQLIEPSVFKEAASPEEESEVAEKEPFVEDSKLEGAAEEENKGAKRPKEGLLQMKLPEP VKLQMCLLLQYLCDCQVRHRIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARK TKEFRSPPQEQINMLLNFKDDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDRSLDGNN DLTIRGRLLSLVEKVTYLKKKQAEKPVESDSKKSSTLQQLISETMVRWAQESVIEDPELV RAMFVLLHRQYDGIGGLVRALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKL MIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLC YFCRISRQNQKAMFDHLSYLLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPD LEKVVRYLAGCGLQSCQMLVSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVV RLLIRRPECFGPALRGEGGNGLLAAMEEAIKIAEDPSRDGPSPTTGSSKTPDTEEEEDDT IHMGNAIMTFYSALIDLLGRCAPEMHLIHAAKGEAIRIRSILRSLIPLGDLVGVISIAFQ MPTIAKDGNVVEPDMSAGFCPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAAS LDTAALSATDMALALNRYLCTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSL TKAQRDSIEVCLLSICGQLRPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYY CLPGGWGNFGAASEEELHLSRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYM ESNYVSMMEKQSSMDSEGNFNPQPVDTSNITIPEKLEYFINKYAEHAHDKWSMDKLANGW IYGEIYSDSSKVQPLMKPYKLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALY NRTRRISQTSQVSVDAAHGYSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKLELE AKGGGNHPLLVPYDTLTAKEKAKDREKAQDILKFLQISGYAVSRGFKDLELDTPSIEKRF AYSFLQQLIRYVDEAHQYILEFDGGSRSKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLY FLSAASRPLCSGGHASNKEKEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLD ARTVMKTGLESVKSALRAFLDNAAEDLEKTMENLKQGQFTHTRNQPKGVTQIINYTTVAL LPMLSSLFEHIGQHQFGEDLILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAA FAGAFPVAFLETHLDKHNIYSIYNTKSSRERAALNLPANVEDVCPNIPSLEKLMEEIVDL AESGIRYTQMPHVMEVVLPMLCSYMSRWWEHGPENNPGRAEMCCTALNSEHMNTLLGNIL KIIYNNLGIDEGAWMKRLAVFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLK SEARGDMSEAELLILDEFTTLARDLYAFYPLLIRFVDYNRAKWLKEPNQEAEDLFRMVAE VFIYWSKSHNFKREEQNFVVQNEINNMSFLIMDTKSKMSKAAVSDQERKKMKRKGDRYSM QTSLIVAALKRLLPIGLNICAPGDQELIALAKNRFSLKDTEDEVRDIIRSNIHLQGKLED PAIRWQMALYKDLPNRTEDTSDPEKTVERVLDIANVLFHLEQKSTCMRRRYYNLVEHPQR SKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLI EDLAKPGAEPPEEDEGTKRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHD EEDDDGEEEVKSFEVTGSQRSKEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGETGP MVAATLKLGIAILNGGNSTVQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNK AEGLGMVTEEGSGEKVLQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIIS TVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQ SLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNG TIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAME SHKHYTQSETEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDT RLQTFLELAESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFI FDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESDLNERSANKEESEKEKPEEQGPRM GFFSIMTVKSALFALRYNILTLMRMLSLKSLKKQMKKVKKMTVKDMITAFFTSYWSILMS LLHFVASVFRGFSRIIGSLLLGGSLVEGAKKIKVAELLANMPDPTQDEVRGDGEEGERKT LEGALPSEDLTDLKELSEESDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLMSNPVPIP EVQEKFQEQKAKEEEKEEKEESKSEPEKAEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEP EVPESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSVVEGKEL PTRSSSENARVSSLDSSSPRIIAVHYVLEESSGYMEPTLRILAILHTVISFFCIIGYYCL KVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKV MDKYGEFYGRDRISELLGMDKAALDFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVV FTDNSFLYLAWYMTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGL LAVVVYLYTVVAFNFFRKFYNKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIED PAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGI GNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFP AGDCFRKQYEDQLN NT seq 14625 nt NT seq  +upstreamnt  +downstreamnt atgcagactgctcaaggtggtggccaccgaacgctcctctacggtcatgcaatactgctg cggcattcctacagtggcatgtatctgtgctgcctgtccacctctcggtcttcaactgat aagctggcttttgatgttggcttgcaagaggatacaacaggtgaagcttgttggtggatc atccatcctgcctctaagcagcgctcagaaggagaaaaagtgcgggttggagatgacctc atcttagtgagcgtgtcctctgaaaggtacctgcacttgtcttacggtaacggcagcttg cacgtggatgctgctttccagcagaccctctggagtgtggcccccatcagctcaggaagt gaagcagcccaagggtatctgattggtggtgacgtcctcaggttgcttcatggacacatg gatgaatgcctcactgtcccttcaggagaacacggtgaagagcagcggagaactgttcat tacgaaggtggtgctgtatcggttcacgcacgttccctgtggcgactggagacactaaga gttgcgtggagtggaagccacataaggtggggacaaccttttcgactacgccatgtcaca acaggaaaatacttgagtctcatggaagacaaaagccttctactcatggacaaagaaaaa gctgatgtcaaatcaactgcatttaccttccgatcttccaaggaaaaattggatgtagga gtgagaaaagaagttgatggcatgggaacctctgaaataaaatatggagactcagtatgt tatatacagcatatcaatacaggcttgtggctgacttaccagtctgtggatgtgaaatcg gtgagaatgggatccatacaacgtaaggctattatgcatcatgaaggacacatggatgat ggcctaaatttatccagatctcagcatgaagaatcacggacagcacgcgtcatccggagc acagtcttcctttttaatagatttattaggggccttgatgctctcagcaaaaaggtgaaa gcttccacagtagacttacctatagagtctgtaagtctgagtctgcaggaccttattggc tacttccacccaccagatgagcatttagagcatgaagataagcagaacagattacgagct ctgaagaataggcagaatctcttccaggaagagggaatgatcaaccttgtgctcgagtgt atagacaggctgcatgtgtatagcagtgctgcacacttcgctgatgttgctgggagagaa gcaggggaatcttggaaatcgattctgaattctctgtatgagttgctggcggcattaatt agaggaaatcgtaaaaactgtgctcaattttctggctcccttgactggttaatcagccga ctggaaagactggaagcttcttctggtattcttgaagttttacactgtgtgttagtagaa agtccagaagctctaaatattattaaagaaggccatataaaatccattatctcactttta gacaagcatggaagaaatcacaaggttctggatgtcttatgctctctctgtgtttgccat ggagtagcagtccgttctaaccagcatctcatctgtgacaatcttctgccaggaagagac ctgttattgcagacacgccttgtgaaccacgtgagcagcatgagacccaatatttttctg ggtgtcagtgaaggatctgcacagtataagaagtggtattatgagttgatggtggaccac actgagccattcgtgactgctgaagccactcacctgcgagtgggctgggcttccacagag gggtactcaccctaccctggagggggtgaagagtggggtggaaatggtgtcggagatgac ctcttctcctacggatttgatggccttcacctctggtcaggttgtattgcccggacggtc agctcaccaaaccagcatctcttgagaactgatgatgtcatcagttgctgtctagatcta agtgccccaagcatctccttccgaattaatggacaacctgttcaaggcatgtttgagaat ttcaacattgatggcctcttctttccagttgtcagtttctctgcaggaatcaaagtacgc tttctgcttggggggagacatggagaatttaaattccttcctccgcctgggtatgctcct tgttatgaagctgtgctgccaaaagagaagttgaaagtggagcacagccgagagtacaag caagaaaggacttacacgcgggacctcctgggccccacggtttccctgacacaagctgcc ttcacaccaatcccagtggacaccagccagattgtgttgcctccccacctggagaggata cgagaaaaactggcagagaatatccatgagctctgggtgatgaataaaattgaacttggc tggcagtacggtccggttagagatgacaataagagacagcacccgtgtctggtggagttc tccaagctgcctgaacaggaacgcaattacaatttacagatgtcacttgagaccctgaag acgttgttggctttaggatgtcatgtgggtatatcagatgaacacgctgaagaaaaagtg aaaaaaatgaagctgccaaagaattaccaactgacaagtggatacaagcctgccccaatg gacctgagctttattaaactcaccccatctcaggaggctatggtggacaagctggcagaa aatgctcataacgtgtgggctcgggatcgaattcgacaaggctggacctatgggatccaa caggatgtaaagaacagaagaaaccctcggcttgttccctatgcccttctagatgaccga actaagaaatccaataaggatagcctccgtgaggctgtacgcacactgctgggatatggc tacaacctggaggcacctgatcaagatcatgctgccagagctgaagtgtgcagcggcacg ggagagaggttccgcatcttccgtgctgagaaaacatatgctgtgaaggctggaaggtgg tattttgaattcgaggcggtcactgctggagacatgcgagttggctggagcaggccaggg tgtcaacctgatcaggagcttggctcagatgaacgtgcctttgcttttgatggcttcaag gcccagcggtggcaccagggcaatgagcactatgggcgctcttggcaagctggcgacgtt gtggggtgtatggttgacatgacagaacacaccatgatgttcacactgaatggcgaaatc cttcttgatgattccggttcagagctggctttcaaggactttgatgttggtgatggattc atacctgtgtgtagcctgggagtggctcaagtgggcaggctgaactttggaaaggatgtc agcaccttgaaatatttcaccatctgtggcttacaagagggctatgaaccatttgccgtt aacacaaatagggatattaccatgtggctgagcaagaggcttcctcaatttctccaagtt ccatcaaaccatgaacatattgaggtgaccagaatagatggcaccatagacagttccccg tgtttaaaagtcactcagaagtcctttggctctcagaacagcagcacggatatcatgttt tatcgtctgagcatgcccatcgagtgtgcagaggtcttctccaagactgcagctggaggg atccctggcaccgggctctttgggcccaagaatgatctggaggattatgatgtggattca gactttgaggttctcatgaagacagctcacggccatctggtgccagatcgaggagataga gacaaagaagctacaaaaccagagtttaataaccacaaggattatgctcaggaaaaaccc tctcgtctgaaacagaggtttttgcttcgaagaacaaagccagattatagcaccagccat tctgcacgactcactgaagatgtccttgcagatgagagggatgactacgattacttgatg caaacgtccacgtactattactcagtgagaatctttcctggacaagaacctgccaatgtc tgggtgggctggatcacatccgatttccatcagtatgatacaggctttgacttggacaga gttcgtacagtgaccgtgactctgggagatgaaaaaggaaaggtgcacgaaagcatcaaa cgcagcaattgctacatggtgtgtgcgggtgagagcctgagcccggggcaaggacggaac aacaacggcctggagattggctgcgtggtggatgctgccagtgggctgctcaccttcacg gccaacggcaaggaactgagcacctattatcaggtggaaccaagcacaaaattatttcct gcagtttttgcacaagctacaagtcctaatgtttttcagtttgagttgggaagaataaag aatgtgatgcctctctcagcgggattattcaagagtgagcacaaaaatcctgtgccacag tgtcccccacgtctccatgtgcagtttctctcacatgtcctgtggagcagaatgcccaac cagttcttgaaggtagacgtctctcgaataagtgaacgccagggctggctggtgcagtgc gtggagcctctgcagttcatgtcacttcacatcccagaggagaacagatctgtggacata ctggaactgacagagcaggaggaactactgaaattccactaccacactctccggctctac tcggccgtctgcgcgctcgggaaccaccgggtggcccacgccttgtgcagccacgtggac gagccgcagctgctctacgccatcgagaacaagtacatgcccggcttgctgcgcgccggc tactacgacctgctgattgacatccacctcagctcctacgccaccgccaggctcatgatg aacaacgagttcatcgtccccatgaccgaggagaccaagagcatcaccctcttcccggat gagaagaaaaagcacgggctgccgggcatcggcctcagcacctccctcaggccgcggatg cagttttcctccccgagttttgtcagcattaataccgagggttaccagtacagcccagag ttcccgctggacatcctgaaggccaagaccatacagatgctgacagaagccgtgaaagag ggcagccttcatgcccgagaccccgttgggggcaccactgagttcctcttcgtccctctc atcaagctgttctataccctgctcatcatgggtgtcttccacaacgaggacttgaaacac gtcttgcagttgattgagcctagtgtgttcaaggaagccgccagcccggaggaggagagc gaggtggcggagaaggaaccctttgtggaagactccaagctagaaggagccgctgaggaa gaaaacaaaggggctaagaggcccaaggagggcctgctccaaatgaaactgccagagcca gtaaaattgcagatgtgcctgctacttcaatacctctgtgactgccaggtccggcaccgg atagaagccattgtggccttttcagatgactttgtagccaagctccaagacaatcaacga ttccgatataatgaagttatgcaagccttaaacatgtcggctgcactcacagccaggaaa acaaaggaattcagatccccgcctcaagaacagatcaatatgcttctcaattttaaggat gacaaaagtgaatgtccatgtcctgaagaaatccgagaccaactcttggattttcacgaa gatttgatgacacattgtggaattgagctggatgaagataggtctctggatggaaacaat gatttaactattagaggacgcctgctgtccttggtagaaaaggtgacatacctgaagaag aagcaagcggaaaagccagttgagagtgactccaagaagtcatccactcttcagcagttg atttctgagaccatggtccgatgggctcaagagtctgttattgaagaccctgaattggtg agggccatgtttgtattgctccatcgacagtatgatggcattgggggtctggtacgggct ctgccaaagacctacactataaatggtgtttctgtggaggataccatcaatctgctggca tctcttggtcagattcgttctctgctaagtgtgagaatgggcaaagaggaagagaaactt atgattcgtggattaggggatatcatgaacaataaagtgttttaccagcatcctaatctc atgagggcccttgggatgcatgagacagtgatggaggtcatggtgaatgtccttggaggt ggagagtccaaggaaatcacttttccgaagatggtggccaactgttgccgttttctctgt tacttctgtcgtataagcaggcagaatcagaaagctatgtttgatcatctgagttattta ctggaaaacagcagtgttggtcttgcctcaccagctatgagaggttcaacaccactggat gtggcagcagcctcggtgatggataataatgaactagctttagctttgcgggagccagat ctggaaaaggtggttcggtatttggctggttgtggactgcagagttgccagatgctagtg tcaaagggttatccagacattgggtggaatccagttgaaggagagagatatcttgacttt ctcagatttgctgtcttctgtaatggggaaagcgtggaggagaacgcaaatgtagtggtg agattgctcatccggaggcctgagtgtttcggtcccgccttgaggggggaaggtgggaat ggcctgcttgcagccatggaagaagccataaaaatagccgaggatccctctagagatggt ccctcaccaactaccggatccagcaaaacccctgatacagaagaggaagaggatgatacc atccacatgggaaatgccatcatgaccttttattcagctttaattgacctgttaggacga tgtgctcctgaaatgcatttgattcatgctgccaaaggagaagccatcagaatcaggtct attttgagatctctgattccattgggagatttggtgggagtgatcagcatcgcttttcag atgcccacaatagccaaagatgggaatgtggtggagcctgacatgtctgcggggttttgt ccagaccacaaggcagccatggttttgttccttgacagggtctatggaattgaggttcaa gatttcctcctccatcttctcgaggttggctttctgccagatctccgggctgctgcttct ttagacacggctgctttgagtgctacagacatggccctggcgctcaatcggtacctgtgc acagccgtgttacccttgttaacaaggtgtgctcctctttttgctggcaccgagcaccat gcttctctcattgactcattacttcacactgtgtacaggctttctaagggctgctcactt accaaagctcaacgggattccatagaagtgtgtttgctctctatttgtggccaattgaga ccttctatgatgcaacacttactcagaagattagtatttgatgtcccattattaaatgaa catgcaaagatgcctcttaagctgctgacaaatcattatgaaagatgctggaaatattac tgcctgcctggagggtggggcaactttggagctgcctcagaagaagaacttcatttgtca agaaagctgttctggggcatctttgatgccctgtctcaaaagaaatatgaacaagaactt ttcaaactggcactgccttgcctgagtgcagttgcgggagctttgcctccagactacatg gagtcaaattatgtcagtatgatggaaaaacagtcatcaatggattctgaagggaacttt aatccacaacctgttgatacctcaaatattacaattcctgagaagttggaatacttcatt aacaaatatgcagaacatgcccatgacaagtggtcaatggataagttggcaaatggatgg atttatggagaaatatattcagactcatctaaagttcaaccattaatgaagccatataaa ctattatctgaaaaggaaaaagaaatttatcgctggccaatcaaagaatctttaaaaact atgctggcttggggatggagaattgaaaggacccgagagggagacagcatggccctttat aaccgtactcgtcgtatttctcagacaagtcaggtttctgtagatgccgcccatgggtac agcccacgagccattgacatgagcaatgttacactatccagagatctgcacgctatggca gaaatgatggctgaaaactaccataatatatgggcaaagaaaaagaaactggaactggag gccaaaggaggtggaaaccatcccctactggtaccttatgatacactgacagccaaagag aaagccaaggatagggaaaaagcacaggacatcctcaagttcctgcagatcagcggctac gctgtatccagagggttcaaagacctggaactggacacaccttctattgagaaacggttt gcctatagtttccttcagcaactcattcgctatgtagacgaggcccatcagtatatcctg gagtttgatggtggcagcagaagcaaaggagaacatttcccttatgaacaagaaatcaag ttctttgctaaagtcgttcttcctttaattgatcagtatttcaaaaaccaccgtttatac ttcttatctgcagcaagcagacctctctgttctggaggacatgcatcaaacaaagagaaa gaaatggtgactagcctattctgcaaacttggagttcttgtcaggcataggatttcacta tttgggaacgatgcaacatcaattgtcaactgtcttcatattttgggtcagactttggat gcaaggactgtgatgaagactggcctggagagtgttaaaagtgcactcagagccttcctg gacaatgccgcagaggatctggagaagacgatggagaatcttaagcagggccagttcact cacacccgaaaccaacccaaaggtgttactcagattatcaattataccacggtggcactg ttaccaatgctgtcatcattatttgagcatattggccagcatcaattcggagaagatcta atattggaagatgtacaggtgtcatgttatagaattctgactagcttgtatgctttggga accagcaagagtatttatgtggaaaggcaacgttctgcattgggagaatgtctggctgct tttgctggtgcctttcctgtagcatttttggaaactcacctggacaagcacaatatttac tccatctacaatacaaagtcttcgagagagagagcagctcttaatttgcctgctaacgtg gaagatgtttgtccaaatataccgtctttggagaagctcatggaagaaattgtggacttg gctgagtccgggattcgctacacacagatgccacacgtgatggaagttgtcctgcccatg ctttgtagttacatgtctcgttggtgggagcatgggcctgagaataatccgggaagggct gagatgtgctgtacagctctgaactcagagcacatgaacacgctgctgggcaatatcctg aaaatcatatataataacttgggtattgatgagggagcctggatgaagaggttagcagtg ttttcccagcctattataaataaagtgaaacctcagctcttgaaaactcatttcttgcca ttaatggagaagctcaagaaaaaggcagcaatggtggtatcagaagaggaccatctgaaa tctgaggccaggggagatatgtctgaagctgaacttctcatcctagatgagttcaccaca ctggccagagatctctatgccttctatccgctcctgattagatttgtggactataacagg gcaaaatggctgaaagagcctaaccaagaagcagaagatcttttccgcatggttgctgag gtgtttatctactggtcaaaatcccataatttcaaaagggaggagcagaactttgtggtg cagaatgaaatcaacaatatgtctttccttattatggacaccaagtcaaagatgtccaag gcagctgtttctgatcaggaaaggaagaaaatgaagcgcaaaggggaccgatattccatg cagacatctcttattgtggccgctctgaagcggttgctgcccattgggttgaacatctgt gcccctggggaccaggagctcattgcactggccaaaaatcgctttagtctgaaagacact gaggatgaagttcgagatataatccgcagtaatattcacttacaaggcaagttggaggat cctgctattagatggcaaatggctctttacaaagacttacccaataggacagaagacact tcagatcctgagaagacagtggaaagggtcttggatatagcaaatgtactttttcatctt gaacagaaatctacatgtatgcgccggagatattacaatctggttgagcatcctcagaga tcaaaaaaggccgtgtggcacaaactgctctctaagcagaggaaacgagctgtggttgct tgcttccggatggctcctttatataatctgccgaggcatcgggctgtcaatctctttctt cagggatatgaaaagtcttggattgagacagaagaacattactttgaagataaattgata gaagacttagcgaaacctggagcagaacctccagaagaagatgaaggaactaagagggtt gatcctcttcatcagctgatccttctgtttagtcgaacagctttaacggagaaatgcaaa ctggaggaagattttttatatatggcttatgcagatattatggcaaagagttgtcatgat gaggaagatgatgatggggaagaggaagtgaagagttttgaagtcacaggatcccaacgc agcaaggaaaaagaaatggaaaagcaaaagcttctataccaacaagccaggctccatgac cgcggtgctgctgagatggtgctgcagaccatcagtgccagcaaaggtgaaactggaccc atggtggctgctactttgaaacttggaattgctatcttaaatggagggaactctacagta cagcagaaaatgcttgactacctcaaggagaaaaaggacgtgggcttctttcagagcctg gctggcctgatgcagtcatgcagtgtcctcgacctaaatgcatttgagcgacaaaacaaa gctgaaggacttgggatggtgactgaggaaggatcaggagaaaaggttctgcaggatgac gaattcacctgtgacctcttccgcttcttgcaactgctttgtgagggacacaactcagat tttcaaaattatctgagaactcagactggcaataatacaactgtcaacataatcatctct actgtagactaccttctgagagttcaggaatcaattagtgatttctattggtattactct ggaaaagatgtcattgatgaacaaggacaaaggaatttctccaaagctattcaagtggca aaacaagtctttaacactcttacagagtatattcagggtccttgcactggcaaccagcag agtttggctcacagcaggctctgggatgctgtggtgggttttcttcatgtatttgcccac atgcagatgaagctgtctcaggactccagtcaaattgagctactgaaagaactgatggat cttcagaaggacatggtggtcatgttgctgtccatgttggaaggcaatgttgttaatggc accattggcaaacagatggttgatatgctcgtggaatcttccaacaacgtggagatgatt ctcaagttttttgacatgttcttaaagctcaaggacttgacgtcttctgataccttcaaa gagtatgaccccgatggtaagggagttatttccaagagggactttcacaaagccatggag agccataaacactacacccagtccgagactgagtttctcctgtcctgtgcagagacagat gaaaatgaaaccctggactatgaagaatttgtcaaacggttccacgagcctgccaaggac attggcttcaatgtggcagtgcttctgacaaacctctccgaacacatgcccaatgacacc cggctgcagacttttctggaattggccgagagcgtgctcaattacttccagcccttcctg ggccgcatcgagatcatgggcagtgccaagcgcatcgagagggtgtattttgaaatcagt gagtccagccgaacccagtgggaaaagccccaggtcaaggaatccaaaaggcaatttata tttgacgtggtcaatgaaggaggggagaaagagaagatggagctcttcgtgaacttctgc gaggataccatctttgagatgcaactggcggctcagatttcagagtcagatctgaatgag aggtcagcgaataaagaggagagtgagaaggagaagccggaggagcagggtccgaggatg ggtttcttttccatcatgacggtcaagtccgccctgtttgccctcaggtacaatatcttg acccttatgcggatgctcagcctgaaaagcttgaagaagcagatgaagaaggtgaagaag atgacagtgaaggacatgatcacagccttctttacatcctactggagtattttgatgagc ctcctgcactttgtagccagcgttttcagaggcttctctcgcatcatcggcagcctcctg ctgggaggaagcctggtcgaaggtgcgaagaagatcaaagtggcggagctcttggccaac atgccagaccccacacaagatgaggttcgaggagacggggaggagggggagaggaaaacc ctggaaggggccctgccctctgaagacctgacggacttgaaggaactgtcagaggagagt gacctgctttccgatatctttggcttggacctgaagcgagaaggagggcagtacaaactg attcctcacaatcccaatgctggcctgagtgacctcatgagcaaccccgtccccatccca gaggtgcaagaaaagttccaggagcagaaggcaaaagaagaagaaaaggaagaaaaagaa gaaagcaaatccgaacccgagaaagctgaaggagaagatggagaaaaagaagaaaaagcc aaagaagacaagggtaaacaaaaactgaggcagctccacacacacagatatggagagcca gaagttcctgagtcagcattctggaagaaaatcatagcctatcaacagaaacttctgaac tattttgctcgcaacttctacaacatgagaatgttagccttatttgtcgcatttgcgatc aatttcatcttgctcttttataaggtctccacttcttctgtggttgaaggaaaggaacta cccactcgcagttcaagtgaaaatgccagagttagcagcttggacagcagctcgcctaga atcatcgcagtgcactatgtgctggaggagagcagtggctacatggagcccacactgcgg atattagccattctgcacacggtcatctctttcttctgtatcattggatactactgcttg aaagtcccactggttatttttaagcgagagaaggaagtagctcgaaaattggaatttgat gggctttatattacagaacagccttcagaagatgatattaaaggccagtgggatagactc gtaatcaatacacagtcatttcccaacaactactgggacaaatttgttaaaagaaaggtt atggataaatatggagagttctatggccgagacagaatcagcgagttactcggcatggac aaagctgccttggacttcagtgatgcccgggaaaagaagaagccaaagaaagacagctcc ctgtcagctgtactgaactctattgatgtgaagtatcagatgtggaaactaggagtcgtt ttcactgacaactccttcctctaccttgcctggtatatgaccatgtccattcttggacac tacaacaactttttttttgctgctcatcttctggacattgctatgggattcaagacgtta agaaccatcttgtcatcagtaactcacaatggcaaacagcttgtattaactgttggctta ttggctgttgttgtatacctatatactgtcgtggcattcaattttttccgaaaattctac aataaaagtgaagatggtgatacaccagacatgaagtgtgatgacatgctaacgtgctat atgttccacatgtatgttggagtacgtgctggagggggtatcggtgatgaaatcgaagat ccagctggtgatgagtatgagatatatcgaatcatctttgacatcaccttcttctttttt gtaattgtcattctcttggccataatacaaggtttaatcatcgatgcttttggggaacta agagaccaacaggaacaggtcaaagaagacatggagaccaagtgcttcatctgtgggata ggcaatgattactttgacaccgtgccacatggctttgaaacccacactttacaggaacac aacttggccaattatctgttttttctgatgtatctcataaacaaagatgaaacagagcac acaggccaggaatcttatgtttggaagatgtatcaagaaaggtgctgggaatttttccca gccggagactgtttccggaaacagtatgaagaccagctaaattaa

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