KEGG   Bos javanicus (banteng): 133255661
Entry
133255661         CDS       T11659                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1 isoform X1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
bjv  Bos javanicus (banteng)
Pathway
bjv01521  EGFR tyrosine kinase inhibitor resistance
bjv01522  Endocrine resistance
bjv04010  MAPK signaling pathway
bjv04012  ErbB signaling pathway
bjv04014  Ras signaling pathway
bjv04015  Rap1 signaling pathway
bjv04022  cGMP-PKG signaling pathway
bjv04024  cAMP signaling pathway
bjv04062  Chemokine signaling pathway
bjv04066  HIF-1 signaling pathway
bjv04068  FoxO signaling pathway
bjv04071  Sphingolipid signaling pathway
bjv04072  Phospholipase D signaling pathway
bjv04114  Oocyte meiosis
bjv04140  Autophagy - animal
bjv04148  Efferocytosis
bjv04150  mTOR signaling pathway
bjv04151  PI3K-Akt signaling pathway
bjv04210  Apoptosis
bjv04218  Cellular senescence
bjv04270  Vascular smooth muscle contraction
bjv04370  VEGF signaling pathway
bjv04371  Apelin signaling pathway
bjv04380  Osteoclast differentiation
bjv04510  Focal adhesion
bjv04517  IgSF CAM signaling
bjv04519  Cadherin signaling
bjv04540  Gap junction
bjv04550  Signaling pathways regulating pluripotency of stem cells
bjv04613  Neutrophil extracellular trap formation
bjv04620  Toll-like receptor signaling pathway
bjv04650  Natural killer cell mediated cytotoxicity
bjv04660  T cell receptor signaling pathway
bjv04662  B cell receptor signaling pathway
bjv04664  Fc epsilon RI signaling pathway
bjv04666  Fc gamma R-mediated phagosome formation
bjv04668  TNF signaling pathway
bjv04720  Long-term potentiation
bjv04722  Neurotrophin signaling pathway
bjv04725  Cholinergic synapse
bjv04726  Serotonergic synapse
bjv04730  Long-term depression
bjv04810  Regulation of actin cytoskeleton
bjv04910  Insulin signaling pathway
bjv04912  GnRH signaling pathway
bjv04914  Progesterone-mediated oocyte maturation
bjv04915  Estrogen signaling pathway
bjv04916  Melanogenesis
bjv04917  Prolactin signaling pathway
bjv04919  Thyroid hormone signaling pathway
bjv04921  Oxytocin signaling pathway
bjv04926  Relaxin signaling pathway
bjv04928  Parathyroid hormone synthesis, secretion and action
bjv04929  GnRH secretion
bjv04934  Cushing syndrome
bjv04935  Growth hormone synthesis, secretion and action
bjv05010  Alzheimer disease
bjv05022  Pathways of neurodegeneration - multiple diseases
bjv05034  Alcoholism
bjv05132  Salmonella infection
bjv05135  Yersinia infection
bjv05160  Hepatitis C
bjv05161  Hepatitis B
bjv05163  Human cytomegalovirus infection
bjv05164  Influenza A
bjv05165  Human papillomavirus infection
bjv05166  Human T-cell leukemia virus 1 infection
bjv05167  Kaposi sarcoma-associated herpesvirus infection
bjv05170  Human immunodeficiency virus 1 infection
bjv05200  Pathways in cancer
bjv05205  Proteoglycans in cancer
bjv05206  MicroRNAs in cancer
bjv05207  Chemical carcinogenesis - receptor activation
bjv05208  Chemical carcinogenesis - reactive oxygen species
bjv05210  Colorectal cancer
bjv05211  Renal cell carcinoma
bjv05212  Pancreatic cancer
bjv05213  Endometrial cancer
bjv05214  Glioma
bjv05215  Prostate cancer
bjv05216  Thyroid cancer
bjv05218  Melanoma
bjv05219  Bladder cancer
bjv05220  Chronic myeloid leukemia
bjv05221  Acute myeloid leukemia
bjv05223  Non-small cell lung cancer
bjv05224  Breast cancer
bjv05225  Hepatocellular carcinoma
bjv05226  Gastric cancer
bjv05230  Central carbon metabolism in cancer
bjv05231  Choline metabolism in cancer
bjv05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:bjv00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    133255661 (MAP2K1)
   04012 ErbB signaling pathway
    133255661 (MAP2K1)
   04014 Ras signaling pathway
    133255661 (MAP2K1)
   04015 Rap1 signaling pathway
    133255661 (MAP2K1)
   04370 VEGF signaling pathway
    133255661 (MAP2K1)
   04371 Apelin signaling pathway
    133255661 (MAP2K1)
   04668 TNF signaling pathway
    133255661 (MAP2K1)
   04066 HIF-1 signaling pathway
    133255661 (MAP2K1)
   04068 FoxO signaling pathway
    133255661 (MAP2K1)
   04072 Phospholipase D signaling pathway
    133255661 (MAP2K1)
   04071 Sphingolipid signaling pathway
    133255661 (MAP2K1)
   04024 cAMP signaling pathway
    133255661 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    133255661 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    133255661 (MAP2K1)
   04150 mTOR signaling pathway
    133255661 (MAP2K1)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    133255661 (MAP2K1)
   04519 Cadherin signaling
    133255661 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    133255661 (MAP2K1)
   04148 Efferocytosis
    133255661 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    133255661 (MAP2K1)
   04210 Apoptosis
    133255661 (MAP2K1)
   04218 Cellular senescence
    133255661 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    133255661 (MAP2K1)
   04540 Gap junction
    133255661 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    133255661 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    133255661 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    133255661 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    133255661 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    133255661 (MAP2K1)
   04660 T cell receptor signaling pathway
    133255661 (MAP2K1)
   04662 B cell receptor signaling pathway
    133255661 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    133255661 (MAP2K1)
   04666 Fc gamma R-mediated phagosome formation
    133255661 (MAP2K1)
   04062 Chemokine signaling pathway
    133255661 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    133255661 (MAP2K1)
   04929 GnRH secretion
    133255661 (MAP2K1)
   04912 GnRH signaling pathway
    133255661 (MAP2K1)
   04915 Estrogen signaling pathway
    133255661 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    133255661 (MAP2K1)
   04917 Prolactin signaling pathway
    133255661 (MAP2K1)
   04921 Oxytocin signaling pathway
    133255661 (MAP2K1)
   04926 Relaxin signaling pathway
    133255661 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    133255661 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    133255661 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    133255661 (MAP2K1)
   04916 Melanogenesis
    133255661 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    133255661 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    133255661 (MAP2K1)
   04726 Serotonergic synapse
    133255661 (MAP2K1)
   04720 Long-term potentiation
    133255661 (MAP2K1)
   04730 Long-term depression
    133255661 (MAP2K1)
   04722 Neurotrophin signaling pathway
    133255661 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    133255661 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    133255661 (MAP2K1)
   05206 MicroRNAs in cancer
    133255661 (MAP2K1)
   05205 Proteoglycans in cancer
    133255661 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    133255661 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    133255661 (MAP2K1)
   05230 Central carbon metabolism in cancer
    133255661 (MAP2K1)
   05231 Choline metabolism in cancer
    133255661 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    133255661 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    133255661 (MAP2K1)
   05212 Pancreatic cancer
    133255661 (MAP2K1)
   05225 Hepatocellular carcinoma
    133255661 (MAP2K1)
   05226 Gastric cancer
    133255661 (MAP2K1)
   05214 Glioma
    133255661 (MAP2K1)
   05216 Thyroid cancer
    133255661 (MAP2K1)
   05221 Acute myeloid leukemia
    133255661 (MAP2K1)
   05220 Chronic myeloid leukemia
    133255661 (MAP2K1)
   05218 Melanoma
    133255661 (MAP2K1)
   05211 Renal cell carcinoma
    133255661 (MAP2K1)
   05219 Bladder cancer
    133255661 (MAP2K1)
   05215 Prostate cancer
    133255661 (MAP2K1)
   05213 Endometrial cancer
    133255661 (MAP2K1)
   05224 Breast cancer
    133255661 (MAP2K1)
   05223 Non-small cell lung cancer
    133255661 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    133255661 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    133255661 (MAP2K1)
   05161 Hepatitis B
    133255661 (MAP2K1)
   05160 Hepatitis C
    133255661 (MAP2K1)
   05164 Influenza A
    133255661 (MAP2K1)
   05163 Human cytomegalovirus infection
    133255661 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    133255661 (MAP2K1)
   05165 Human papillomavirus infection
    133255661 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    133255661 (MAP2K1)
   05135 Yersinia infection
    133255661 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    133255661 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    133255661 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    133255661 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    133255661 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    133255661 (MAP2K1)
   01522 Endocrine resistance
    133255661 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:bjv01001]
    133255661 (MAP2K1)
Enzymes [BR:bjv01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     133255661 (MAP2K1)
Protein kinases [BR:bjv01001]
 Serine/threonine kinases: STE group
  STE7 family
   133255661 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7
Other DBs
NCBI-GeneID: 133255661
NCBI-ProteinID: XP_061286130
LinkDB
Position
10:13269981..13345055
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggccccggacggctccgcggtt
aacgggaccagctcggcggagaccaacctggaggccttgcagaagaagctggaggagctg
gagctcgatgaacagcagcggaagcgcctcgaggcctttctgacccagaagcagaaggtg
ggggaactgaaggatgatgactttgagaagatcagtgagctgggtgccggcaatggaggt
gtggtgttcaaggtctcccacaagccgtccggacttgttatggccagaaagctaattcac
ctggagatcaaacctgccatccggaaccagatcataagggagctgcaggttctccatgag
tgcaactcgccttatatcgtgggcttctacggggcgttctacagcgatggcgagatcagc
atctgcatggagcacatggatgggggttccttggatcaagttctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaataaaaggcctgacatacctg
agggagaagcacaagattatgcacagagatgtcaagccgtccaacatcctagtgaacagc
cgtggagagatcaagctctgtgactttggggtcagcgggcagctcatcgactccatggcc
aactccttcgtgggcaccaggtcctacatgtcgccagagcgactccaggggacccattac
tccgtgcagtcggacatctggagcatggggctctctctggttgagatggctgtcgggagg
tatcccatccctcctccagatgccaaggagctggagctgatgtttgggtgccaggtggag
ggagatgcggctgagaccccgcccaggccaaggacccccgggaggcccctcagctcttac
ggaatggacagccgacctccaatggcaatttttgagttgttggattacatagtcaatgag
cctcctccaaaactgcccagtggagtattcagtctggaatttcaagattttgtgaataaa
tgcttaataaaaaaccccgcagagagagcagatttgaagcaactcatggttcatgctttt
atcaagagatctgatgctgaggaagtggattttgcaggttggctctgctccaccatcggc
cttaaccagcccagcacacccacccatgcggctggcgtctaa

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