Bubalus kerabau (carabao): 129638604
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Entry
129638604 CDS
T11435
Symbol
ARAF
Name
(RefSeq) serine/threonine-protein kinase A-Raf isoform X1
KO
K08845
A-Raf proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
bke Bubalus kerabau (carabao)
Pathway
bke01521
EGFR tyrosine kinase inhibitor resistance
bke01522
Endocrine resistance
bke04010
MAPK signaling pathway
bke04012
ErbB signaling pathway
bke04068
FoxO signaling pathway
bke04270
Vascular smooth muscle contraction
bke04650
Natural killer cell mediated cytotoxicity
bke04720
Long-term potentiation
bke04726
Serotonergic synapse
bke04730
Long-term depression
bke04810
Regulation of actin cytoskeleton
bke04910
Insulin signaling pathway
bke04914
Progesterone-mediated oocyte maturation
bke04928
Parathyroid hormone synthesis, secretion and action
bke05010
Alzheimer disease
bke05022
Pathways of neurodegeneration - multiple diseases
bke05034
Alcoholism
bke05160
Hepatitis C
bke05161
Hepatitis B
bke05200
Pathways in cancer
bke05205
Proteoglycans in cancer
bke05208
Chemical carcinogenesis - reactive oxygen species
bke05210
Colorectal cancer
bke05211
Renal cell carcinoma
bke05212
Pancreatic cancer
bke05213
Endometrial cancer
bke05214
Glioma
bke05215
Prostate cancer
bke05218
Melanoma
bke05219
Bladder cancer
bke05220
Chronic myeloid leukemia
bke05221
Acute myeloid leukemia
bke05223
Non-small cell lung cancer
bke05224
Breast cancer
bke05225
Hepatocellular carcinoma
bke05226
Gastric cancer
Brite
KEGG Orthology (KO) [BR:
bke00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
129638604 (ARAF)
04012 ErbB signaling pathway
129638604 (ARAF)
04068 FoxO signaling pathway
129638604 (ARAF)
09140 Cellular Processes
09142 Cell motility
04810 Regulation of actin cytoskeleton
129638604 (ARAF)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
129638604 (ARAF)
09152 Endocrine system
04910 Insulin signaling pathway
129638604 (ARAF)
04914 Progesterone-mediated oocyte maturation
129638604 (ARAF)
04928 Parathyroid hormone synthesis, secretion and action
129638604 (ARAF)
09153 Circulatory system
04270 Vascular smooth muscle contraction
129638604 (ARAF)
09156 Nervous system
04726 Serotonergic synapse
129638604 (ARAF)
04720 Long-term potentiation
129638604 (ARAF)
04730 Long-term depression
129638604 (ARAF)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
129638604 (ARAF)
05205 Proteoglycans in cancer
129638604 (ARAF)
05208 Chemical carcinogenesis - reactive oxygen species
129638604 (ARAF)
09162 Cancer: specific types
05210 Colorectal cancer
129638604 (ARAF)
05212 Pancreatic cancer
129638604 (ARAF)
05225 Hepatocellular carcinoma
129638604 (ARAF)
05226 Gastric cancer
129638604 (ARAF)
05214 Glioma
129638604 (ARAF)
05221 Acute myeloid leukemia
129638604 (ARAF)
05220 Chronic myeloid leukemia
129638604 (ARAF)
05218 Melanoma
129638604 (ARAF)
05211 Renal cell carcinoma
129638604 (ARAF)
05219 Bladder cancer
129638604 (ARAF)
05215 Prostate cancer
129638604 (ARAF)
05213 Endometrial cancer
129638604 (ARAF)
05224 Breast cancer
129638604 (ARAF)
05223 Non-small cell lung cancer
129638604 (ARAF)
09172 Infectious disease: viral
05161 Hepatitis B
129638604 (ARAF)
05160 Hepatitis C
129638604 (ARAF)
09164 Neurodegenerative disease
05010 Alzheimer disease
129638604 (ARAF)
05022 Pathways of neurodegeneration - multiple diseases
129638604 (ARAF)
09165 Substance dependence
05034 Alcoholism
129638604 (ARAF)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
129638604 (ARAF)
01522 Endocrine resistance
129638604 (ARAF)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
bke01001
]
129638604 (ARAF)
Enzymes [BR:
bke01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
129638604 (ARAF)
Protein kinases [BR:
bke01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
129638604 (ARAF)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
RBD
C1_1
Kinase-like
ABC1
zf-RING-like
Pkinase_fungal
TUG-UBL1
Kdo
Motif
Other DBs
NCBI-GeneID:
129638604
NCBI-ProteinID:
XP_055419140
LinkDB
All DBs
Position
X:102287362..102298015
Genome browser
AA seq
611 aa
AA seq
DB search
MEPPRGPPANGAEPSRSVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRRQFYHSVQDLSGSSRQHEVPSNRPLNEPL
TPQSPSLSPASSCTQHRDPEHFSFPAQANTPLQRIRSTSTPNVHMVSTTAPMDSGLIQLT
GQNFNTDAAGNRGGGDGAPRGSPSPASVSSGRKSPHSKSPSEQRERKSLADDKKKVKNLG
YRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEM
QVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQ
GMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAA
EVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKIS
SNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELP
ACLLSAARLAP
NT seq
1836 nt
NT seq
+upstream
nt +downstream
nt
atggagccaccacggggcccccctgctaacggggccgagccctcccggtcagtgggcacc
gtcaaagtgtacctgcccaacaagcagcgcacggtggtgactgtccgggatggcatgagt
gtctatgactctctagacaaggccctcaaggtgcggggtctcaatcaagattgctgtgtg
gtttaccggctcatcaaggggcgaaagacagtcaccgcctgggacacagccattgctccc
ctggatggcgaggagctcattgtggaggtcctcgaagatgtccccctgaccatgcacaat
tttgtacggaagacgttcttcagcctggccttttgtgacttctgccttaagtttctgttc
catggcttccgctgccaaacctgtggatacaagttccaccaacattgttcctccaaggtc
cccacagtctgtgtcgacatgagtaccaaccgccgacagttctaccacagtgtccaggat
ttgtccggaagctccagacagcacgaggttccctcaaaccgccccctgaatgagccgctc
acccctcagagtcccagcctttcccctgccagctcctgcacccagcaccgcgaccccgag
cacttctccttccctgcccaggccaacacccccctccagcgcatccgttccacatccacc
cccaatgtccacatggtcagcaccacagcccccatggactccggcctcatccagcttact
ggccagaatttcaacactgatgctgctgggaatagaggtggtggcgatggagccccccgg
gggagccccagcccagccagcgtgtcctcgggaaggaagtccccacattccaagtcccca
tcagagcagcgggaacggaagtcattggctgatgacaagaagaaagtgaagaatttgggg
taccgggactcgggctattactgggaggtgccacccagtgaggtgcagttgctgaagagg
atcgggacgggctcgtttggcaccgtgtttcgcgggcggtggcatggcgatgtggccgtg
aaggtgctcaaggtggcccaacccacagctgagcaggcccaggccttcaagaacgagatg
caggtgctcaggaagacacgtcacgtcaacatcttgctgttcatgggcttcatgacccgg
ccaggatttgccatcatcacacagtggtgtgagggctccagtctctaccaccacctgcat
gtggctgacacacgcttcgacatggtccagctcattgatgtggcccgccagactgctcag
ggcatggactacctccatgccaagaacatcatccaccgagatctcaagtctaacaacatc
ttcctgcatgaggggctcacggtgaagatcggggacttcggcctggctacagtaaagacg
cggtggagtggggcccagcccttggagcaaccctcgggctctgtgctatggatggcagct
gaggtgatccgtatgcaggacccgaacccctacagcttccagtcagatgtctacgcctat
ggggttgtgctctatgagctcatgaccggctcactgccttacagccacattggcagccga
gaccagattatctttatggtgggccgtggctatctgtccccggacctcagcaaaatctcc
agcaattgccccaaggccatgaggcgcctgctgtctgactgcctgaagttccagcgggag
gagcggcccctttttccccagatcctggccacgattgagctgctgcagcggtcactcccc
aagattgagcggagtgcctccgaaccctccttgcaccgtacccaggctgatgagttgcct
gcctgcctactcagcgcagcccgccttgcgccttag
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